-- dump date 20120504_141034 -- class Genbank::misc_feature -- table misc_feature_note -- id note 412965000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 412965000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 412965000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000004 Walker A motif; other site 412965000005 ATP binding site [chemical binding]; other site 412965000006 Walker B motif; other site 412965000007 arginine finger; other site 412965000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 412965000009 DnaA box-binding interface [nucleotide binding]; other site 412965000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 412965000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 412965000012 putative DNA binding surface [nucleotide binding]; other site 412965000013 dimer interface [polypeptide binding]; other site 412965000014 beta-clamp/clamp loader binding surface; other site 412965000015 beta-clamp/translesion DNA polymerase binding surface; other site 412965000016 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 412965000017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965000018 ATP binding site [chemical binding]; other site 412965000019 Mg2+ binding site [ion binding]; other site 412965000020 G-X-G motif; other site 412965000021 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412965000022 anchoring element; other site 412965000023 dimer interface [polypeptide binding]; other site 412965000024 ATP binding site [chemical binding]; other site 412965000025 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 412965000026 active site 412965000027 putative metal-binding site [ion binding]; other site 412965000028 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412965000029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000030 active site 412965000031 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 412965000032 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 412965000033 HIGH motif; other site 412965000034 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412965000035 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965000036 active site 412965000037 KMSKS motif; other site 412965000038 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 412965000039 tRNA binding surface [nucleotide binding]; other site 412965000040 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 412965000041 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 412965000042 heterodimer interface [polypeptide binding]; other site 412965000043 active site 412965000044 FMN binding site [chemical binding]; other site 412965000045 homodimer interface [polypeptide binding]; other site 412965000046 substrate binding site [chemical binding]; other site 412965000047 AAA domain; Region: AAA_26; pfam13500 412965000048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000049 Stringent starvation protein B; Region: SspB; cl01120 412965000050 stringent starvation protein A; Provisional; Region: sspA; PRK09481 412965000051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965000052 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 412965000053 N-terminal domain interface [polypeptide binding]; other site 412965000054 dimer interface [polypeptide binding]; other site 412965000055 substrate binding pocket (H-site) [chemical binding]; other site 412965000056 Cytochrome c; Region: Cytochrom_C; cl11414 412965000057 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 412965000058 cytochrome b; Provisional; Region: CYTB; MTH00145 412965000059 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 412965000060 Qi binding site; other site 412965000061 intrachain domain interface; other site 412965000062 interchain domain interface [polypeptide binding]; other site 412965000063 heme bH binding site [chemical binding]; other site 412965000064 heme bL binding site [chemical binding]; other site 412965000065 Qo binding site; other site 412965000066 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 412965000067 interchain domain interface [polypeptide binding]; other site 412965000068 intrachain domain interface; other site 412965000069 Qi binding site; other site 412965000070 Qo binding site; other site 412965000071 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 412965000072 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 412965000073 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 412965000074 [2Fe-2S] cluster binding site [ion binding]; other site 412965000075 Protein of unknown function (DUF721); Region: DUF721; cl02324 412965000076 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 412965000077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000078 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 412965000079 SEC-C motif; Region: SEC-C; pfam02810 412965000080 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 412965000081 active site 412965000082 substrate binding pocket [chemical binding]; other site 412965000083 dimer interface [polypeptide binding]; other site 412965000084 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 412965000085 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 412965000086 active site 412965000087 Riboflavin kinase; Region: Flavokinase; cl03312 412965000088 homoserine O-succinyltransferase; Provisional; Region: PRK05368 412965000089 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 412965000090 proposed active site lysine [active] 412965000091 conserved cys residue [active] 412965000092 aminotransferase; Validated; Region: PRK08175 412965000093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412965000094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000095 homodimer interface [polypeptide binding]; other site 412965000096 catalytic residue [active] 412965000097 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 412965000098 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 412965000099 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 412965000100 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 412965000101 ATP binding site [chemical binding]; other site 412965000102 active site 412965000103 substrate binding site [chemical binding]; other site 412965000104 putative peptidase; Provisional; Region: PRK11649 412965000105 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 412965000106 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 412965000107 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 412965000108 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 412965000109 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 412965000110 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 412965000111 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 412965000112 catalytic residue [active] 412965000113 putative FPP diphosphate binding site; other site 412965000114 putative FPP binding hydrophobic cleft; other site 412965000115 dimer interface [polypeptide binding]; other site 412965000116 putative IPP diphosphate binding site; other site 412965000117 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 412965000118 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 412965000119 substrate binding site [chemical binding]; other site 412965000120 glutamase interaction surface [polypeptide binding]; other site 412965000121 UbiA prenyltransferase family; Region: UbiA; cl00337 412965000122 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 412965000123 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 412965000124 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 412965000125 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 412965000126 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 412965000127 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 412965000128 Cytochrome c; Region: Cytochrom_C; cl11414 412965000129 Cytochrome c; Region: Cytochrom_C; cl11414 412965000130 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 412965000131 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 412965000132 Subunit I/III interface [polypeptide binding]; other site 412965000133 D-pathway; other site 412965000134 Subunit I/VIIc interface [polypeptide binding]; other site 412965000135 Subunit I/IV interface [polypeptide binding]; other site 412965000136 Subunit I/II interface [polypeptide binding]; other site 412965000137 Low-spin heme (heme a) binding site [chemical binding]; other site 412965000138 Subunit I/VIIa interface [polypeptide binding]; other site 412965000139 Subunit I/VIa interface [polypeptide binding]; other site 412965000140 Dimer interface; other site 412965000141 Putative water exit pathway; other site 412965000142 Binuclear center (heme a3/CuB) [ion binding]; other site 412965000143 K-pathway; other site 412965000144 Subunit I/Vb interface [polypeptide binding]; other site 412965000145 Putative proton exit pathway; other site 412965000146 Subunit I/VIb interface; other site 412965000147 Subunit I/VIc interface [polypeptide binding]; other site 412965000148 Electron transfer pathway; other site 412965000149 Subunit I/VIIIb interface [polypeptide binding]; other site 412965000150 Subunit I/VIIb interface [polypeptide binding]; other site 412965000151 Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; cl01240 412965000152 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 412965000153 Subunit III/VIIa interface [polypeptide binding]; other site 412965000154 Phospholipid binding site [chemical binding]; other site 412965000155 Subunit I/III interface [polypeptide binding]; other site 412965000156 Subunit III/VIb interface [polypeptide binding]; other site 412965000157 Subunit III/VIa interface; other site 412965000158 Subunit III/Vb interface [polypeptide binding]; other site 412965000159 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 412965000160 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 412965000161 Low-spin heme binding site [chemical binding]; other site 412965000162 Putative water exit pathway; other site 412965000163 Binuclear center (active site) [active] 412965000164 Putative proton exit pathway; other site 412965000165 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 412965000166 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 412965000167 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 412965000168 Cytochrome c; Region: Cytochrom_C; cl11414 412965000169 Cytochrome c; Region: Cytochrom_C; cl11414 412965000170 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 412965000171 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 412965000172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000173 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 412965000174 thioredoxin reductase; Provisional; Region: PRK10262 412965000175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965000176 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 412965000177 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412965000178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000179 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 412965000180 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 412965000181 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 412965000182 ApbE family; Region: ApbE; cl00643 412965000183 CrcB-like protein; Region: CRCB; cl09114 412965000184 glutathione synthetase; Provisional; Region: PRK05246 412965000185 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 412965000186 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965000187 ribosome maturation protein RimP; Reviewed; Region: PRK00092 412965000188 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 412965000189 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 412965000190 Sm1 motif; other site 412965000191 D3 - B interaction site; other site 412965000192 D1 - D2 interaction site; other site 412965000193 Hfq - Hfq interaction site; other site 412965000194 RNA binding pocket [nucleotide binding]; other site 412965000195 Sm2 motif; other site 412965000196 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 412965000197 NusA N-terminal domain; Region: NusA_N; pfam08529 412965000198 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 412965000199 RNA binding site [nucleotide binding]; other site 412965000200 homodimer interface [polypeptide binding]; other site 412965000201 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 412965000202 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 412965000203 G-X-X-G motif; other site 412965000204 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 412965000205 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 412965000206 translation initiation factor IF-2; Validated; Region: infB; PRK05306 412965000207 translation initiation factor IF-2; Region: IF-2; TIGR00487 412965000208 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 412965000209 G1 box; other site 412965000210 putative GEF interaction site [polypeptide binding]; other site 412965000211 GTP/Mg2+ binding site [chemical binding]; other site 412965000212 Switch I region; other site 412965000213 G2 box; other site 412965000214 G3 box; other site 412965000215 Switch II region; other site 412965000216 G4 box; other site 412965000217 G5 box; other site 412965000218 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 412965000219 Translation-initiation factor 2; Region: IF-2; pfam11987 412965000220 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 412965000221 Ribosome-binding factor A; Region: RBFA; cl00542 412965000222 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 412965000223 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 412965000224 RNA binding site [nucleotide binding]; other site 412965000225 active site 412965000226 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 412965000227 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 412965000228 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965000229 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 412965000230 outer membrane lipoprotein; Provisional; Region: PRK11023 412965000231 Predicted methyltransferases [General function prediction only]; Region: COG0313 412965000232 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 412965000233 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 412965000234 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 412965000235 CoA-binding site [chemical binding]; other site 412965000236 ATP-binding [chemical binding]; other site 412965000237 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 412965000238 Catalytic site; other site 412965000239 transketolase; Reviewed; Region: PRK12753 412965000240 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 412965000241 TPP-binding site [chemical binding]; other site 412965000242 dimer interface [polypeptide binding]; other site 412965000243 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412965000244 PYR/PP interface [polypeptide binding]; other site 412965000245 dimer interface [polypeptide binding]; other site 412965000246 TPP binding site [chemical binding]; other site 412965000247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412965000248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000249 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 412965000250 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 412965000251 Phosphoglycerate kinase; Region: PGK; pfam00162 412965000252 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 412965000253 substrate binding site [chemical binding]; other site 412965000254 hinge regions; other site 412965000255 ADP binding site [chemical binding]; other site 412965000256 catalytic site [active] 412965000257 pyruvate kinase; Provisional; Region: PRK05826 412965000258 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 412965000259 domain interfaces; other site 412965000260 active site 412965000261 hypothetical protein; Provisional; Region: PRK08185 412965000262 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 412965000263 intersubunit interface [polypeptide binding]; other site 412965000264 active site 412965000265 zinc binding site [ion binding]; other site 412965000266 Na+ binding site [ion binding]; other site 412965000267 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 412965000268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000270 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 412965000271 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 412965000272 active site 412965000273 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 412965000274 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 412965000275 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 412965000276 active site 412965000277 UbiA prenyltransferase family; Region: UbiA; cl00337 412965000278 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 412965000279 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 412965000280 trimer interface [polypeptide binding]; other site 412965000281 active site 412965000282 substrate binding site [chemical binding]; other site 412965000283 CoA binding site [chemical binding]; other site 412965000284 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 412965000285 4Fe-4S binding domain; Region: Fer4_5; pfam12801 412965000286 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 412965000287 FixH; Region: FixH; cl01254 412965000288 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 412965000289 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000290 Walker A/P-loop; other site 412965000291 ATP binding site [chemical binding]; other site 412965000292 Q-loop/lid; other site 412965000293 ABC transporter signature motif; other site 412965000294 Walker B; other site 412965000295 D-loop; other site 412965000296 H-loop/switch region; other site 412965000297 DNA polymerase I; Provisional; Region: PRK05755 412965000298 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 412965000299 active site 412965000300 metal binding site 1 [ion binding]; metal-binding site 412965000301 putative 5' ssDNA interaction site; other site 412965000302 metal binding site 3; metal-binding site 412965000303 metal binding site 2 [ion binding]; metal-binding site 412965000304 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 412965000305 putative DNA binding site [nucleotide binding]; other site 412965000306 putative metal binding site [ion binding]; other site 412965000307 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 412965000308 active site 412965000309 catalytic site [active] 412965000310 substrate binding site [chemical binding]; other site 412965000311 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 412965000312 active site 412965000313 DNA binding site [nucleotide binding] 412965000314 catalytic site [active] 412965000315 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 412965000316 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 412965000317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965000318 active site 412965000319 HIGH motif; other site 412965000320 nucleotide binding site [chemical binding]; other site 412965000321 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 412965000322 KMSK motif region; other site 412965000323 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412965000324 tRNA binding surface [nucleotide binding]; other site 412965000325 anticodon binding site; other site 412965000326 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 412965000327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000328 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412965000329 thiamine phosphate binding site [chemical binding]; other site 412965000330 active site 412965000331 pyrophosphate binding site [ion binding]; other site 412965000332 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 412965000333 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 412965000334 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 412965000335 ATP-sulfurylase; Region: ATPS; cd00517 412965000336 active site 412965000337 HXXH motif; other site 412965000338 flexible loop; other site 412965000339 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 412965000340 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 412965000341 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 412965000342 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 412965000343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412965000344 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 412965000345 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 412965000346 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 412965000347 adenylate kinase; Reviewed; Region: adk; PRK00279 412965000348 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 412965000349 AMP-binding site [chemical binding]; other site 412965000350 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 412965000351 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 412965000352 active site 412965000353 ADP/pyrophosphate binding site [chemical binding]; other site 412965000354 dimerization interface [polypeptide binding]; other site 412965000355 allosteric effector site; other site 412965000356 fructose-1,6-bisphosphate binding site; other site 412965000357 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 412965000358 active site 412965000359 metal binding site [ion binding]; metal-binding site 412965000360 homotetramer interface [polypeptide binding]; other site 412965000361 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 412965000362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412965000363 active site 412965000364 HIGH motif; other site 412965000365 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 412965000366 KMSKS motif; other site 412965000367 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 412965000368 tRNA binding surface [nucleotide binding]; other site 412965000369 anticodon binding site; other site 412965000370 peroxidase; Provisional; Region: PRK15000 412965000371 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 412965000372 dimer interface [polypeptide binding]; other site 412965000373 decamer (pentamer of dimers) interface [polypeptide binding]; other site 412965000374 catalytic triad [active] 412965000375 peroxidatic and resolving cysteines [active] 412965000376 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 412965000377 Rubredoxin; Region: Rubredoxin; pfam00301 412965000378 iron binding site [ion binding]; other site 412965000379 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 412965000380 tartrate dehydrogenase; Provisional; Region: PRK08194 412965000381 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 412965000382 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 412965000383 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 412965000384 dimer interface [polypeptide binding]; other site 412965000385 ADP-ribose binding site [chemical binding]; other site 412965000386 active site 412965000387 nudix motif; other site 412965000388 metal binding site [ion binding]; metal-binding site 412965000389 diaminopimelate decarboxylase; Region: lysA; TIGR01048 412965000390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 412965000391 active site 412965000392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412965000393 substrate binding site [chemical binding]; other site 412965000394 catalytic residues [active] 412965000395 dimer interface [polypeptide binding]; other site 412965000396 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 412965000397 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 412965000398 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 412965000399 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 412965000400 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 412965000401 dimerization interface [polypeptide binding]; other site 412965000402 active site 412965000403 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 412965000404 active site 412965000405 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 412965000406 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 412965000407 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 412965000408 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 412965000409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412965000410 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 412965000411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 412965000412 DNA binding residues [nucleotide binding] 412965000413 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 412965000414 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 412965000415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412965000416 active site 412965000417 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 412965000418 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 412965000419 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 412965000420 putative active site [active] 412965000421 putative substrate binding site [chemical binding]; other site 412965000422 catalytic site [active] 412965000423 dimer interface [polypeptide binding]; other site 412965000424 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 412965000425 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412965000426 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412965000427 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 412965000428 proline aminopeptidase P II; Provisional; Region: PRK10879 412965000429 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 412965000430 active site 412965000431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 412965000432 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 412965000433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000434 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 412965000435 phosphoglycolate phosphatase; Provisional; Region: PRK13222 412965000436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965000437 motif II; other site 412965000438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412965000439 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 412965000440 inhibitor-cofactor binding pocket; inhibition site 412965000441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000442 catalytic residue [active] 412965000443 primosome assembly protein PriA; Validated; Region: PRK05580 412965000444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412965000445 ATP binding site [chemical binding]; other site 412965000446 putative Mg++ binding site [ion binding]; other site 412965000447 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000448 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 412965000449 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 412965000450 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 412965000451 Ligand Binding Site [chemical binding]; other site 412965000452 TilS substrate binding domain; Region: TilS; pfam09179 412965000453 B3/4 domain; Region: B3_4; cl11458 412965000454 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 412965000455 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 412965000456 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 412965000457 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 412965000458 Phosphate transporter family; Region: PHO4; cl00396 412965000459 Phosphate transporter family; Region: PHO4; cl00396 412965000460 BolA-like protein; Region: BolA; cl00386 412965000461 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412965000462 DEAD-like helicases superfamily; Region: DEXDc; smart00487 412965000463 ATP binding site [chemical binding]; other site 412965000464 Mg++ binding site [ion binding]; other site 412965000465 motif III; other site 412965000466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965000467 nucleotide binding region [chemical binding]; other site 412965000468 ATP-binding site [chemical binding]; other site 412965000469 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 412965000470 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 412965000471 active site 412965000472 HIGH motif; other site 412965000473 dimer interface [polypeptide binding]; other site 412965000474 KMSKS motif; other site 412965000475 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 412965000476 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 412965000477 putative catalytic cysteine [active] 412965000478 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 412965000479 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 412965000480 Lipopolysaccharide-assembly; Region: LptE; cl01125 412965000481 FtsH Extracellular; Region: FtsH_ext; pfam06480 412965000482 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 412965000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000484 Walker A motif; other site 412965000485 ATP binding site [chemical binding]; other site 412965000486 Walker B motif; other site 412965000487 arginine finger; other site 412965000488 Peptidase family M41; Region: Peptidase_M41; pfam01434 412965000489 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 412965000490 dihydropteroate synthase; Region: DHPS; TIGR01496 412965000491 substrate binding pocket [chemical binding]; other site 412965000492 dimer interface [polypeptide binding]; other site 412965000493 inhibitor binding site; inhibition site 412965000494 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 412965000495 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 412965000496 active site 412965000497 substrate binding site [chemical binding]; other site 412965000498 metal binding site [ion binding]; metal-binding site 412965000499 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 412965000500 electron transport complex protein RnfB; Provisional; Region: PRK05113 412965000501 Putative Fe-S cluster; Region: FeS; pfam04060 412965000502 4Fe-4S binding domain; Region: Fer4; cl02805 412965000503 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 412965000504 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 412965000505 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 412965000506 SLBB domain; Region: SLBB; pfam10531 412965000507 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412965000508 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 412965000509 FMN-binding domain; Region: FMN_bind; cl01081 412965000510 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 412965000511 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 412965000512 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 412965000513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000514 CoA-ligase; Region: Ligase_CoA; cl02894 412965000515 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 412965000516 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965000517 CoA-ligase; Region: Ligase_CoA; cl02894 412965000518 elongation factor P; Validated; Region: PRK00529 412965000519 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 412965000520 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 412965000521 RNA binding site [nucleotide binding]; other site 412965000522 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 412965000523 RNA binding site [nucleotide binding]; other site 412965000524 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 412965000525 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 412965000526 dimer interface [polypeptide binding]; other site 412965000527 motif 1; other site 412965000528 active site 412965000529 motif 2; other site 412965000530 motif 3; other site 412965000531 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412965000532 Sel1 repeat; Region: Sel1; cl02723 412965000533 Sel1 repeat; Region: Sel1; cl02723 412965000534 Sel1 repeat; Region: Sel1; cl02723 412965000535 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 412965000536 Sel1 repeat; Region: Sel1; cl02723 412965000537 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 412965000538 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 412965000539 ANP binding site [chemical binding]; other site 412965000540 Substrate Binding Site II [chemical binding]; other site 412965000541 Substrate Binding Site I [chemical binding]; other site 412965000542 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 412965000543 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412965000544 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 412965000545 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965000546 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412965000547 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 412965000548 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412965000549 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965000550 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412965000551 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 412965000552 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 412965000553 active site 412965000554 metal binding site [ion binding]; metal-binding site 412965000555 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 412965000556 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 412965000557 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 412965000558 putative active site [active] 412965000559 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 412965000560 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 412965000561 S17 interaction site [polypeptide binding]; other site 412965000562 S8 interaction site; other site 412965000563 16S rRNA interaction site [nucleotide binding]; other site 412965000564 streptomycin interaction site [chemical binding]; other site 412965000565 23S rRNA interaction site [nucleotide binding]; other site 412965000566 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 412965000567 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 412965000568 elongation factor G; Reviewed; Region: PRK00007 412965000569 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 412965000570 G1 box; other site 412965000571 putative GEF interaction site [polypeptide binding]; other site 412965000572 GTP/Mg2+ binding site [chemical binding]; other site 412965000573 Switch I region; other site 412965000574 G2 box; other site 412965000575 G3 box; other site 412965000576 Switch II region; other site 412965000577 G4 box; other site 412965000578 G5 box; other site 412965000579 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 412965000580 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 412965000581 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 412965000582 elongation factor Tu; Reviewed; Region: PRK00049 412965000583 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412965000584 G1 box; other site 412965000585 GEF interaction site [polypeptide binding]; other site 412965000586 GTP/Mg2+ binding site [chemical binding]; other site 412965000587 Switch I region; other site 412965000588 G2 box; other site 412965000589 G3 box; other site 412965000590 Switch II region; other site 412965000591 G4 box; other site 412965000592 G5 box; other site 412965000593 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412965000594 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412965000595 Antibiotic Binding Site [chemical binding]; other site 412965000596 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 412965000597 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 412965000598 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 412965000599 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 412965000600 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 412965000601 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 412965000602 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 412965000603 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 412965000604 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 412965000605 putative translocon binding site; other site 412965000606 protein-rRNA interface [nucleotide binding]; other site 412965000607 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 412965000608 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 412965000609 G-X-X-G motif; other site 412965000610 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 412965000611 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 412965000612 23S rRNA interface [nucleotide binding]; other site 412965000613 5S rRNA interface [nucleotide binding]; other site 412965000614 putative antibiotic binding site [chemical binding]; other site 412965000615 L25 interface [polypeptide binding]; other site 412965000616 L27 interface [polypeptide binding]; other site 412965000617 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 412965000618 23S rRNA interface [nucleotide binding]; other site 412965000619 putative translocon interaction site; other site 412965000620 signal recognition particle (SRP54) interaction site; other site 412965000621 L23 interface [polypeptide binding]; other site 412965000622 trigger factor interaction site; other site 412965000623 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 412965000624 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 412965000625 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 412965000626 KOW motif; Region: KOW; cl00354 412965000627 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 412965000628 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 412965000629 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 412965000630 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 412965000631 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 412965000632 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 412965000633 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 412965000634 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 412965000635 5S rRNA interface [nucleotide binding]; other site 412965000636 23S rRNA interface [nucleotide binding]; other site 412965000637 L5 interface [polypeptide binding]; other site 412965000638 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 412965000639 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 412965000640 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 412965000641 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 412965000642 23S rRNA binding site [nucleotide binding]; other site 412965000643 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 412965000644 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 412965000645 SecY translocase; Region: SecY; pfam00344 412965000646 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 412965000647 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 412965000648 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 412965000649 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 412965000650 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 412965000651 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 412965000652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412965000653 RNA binding surface [nucleotide binding]; other site 412965000654 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 412965000655 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 412965000656 alphaNTD homodimer interface [polypeptide binding]; other site 412965000657 alphaNTD - beta interaction site [polypeptide binding]; other site 412965000658 alphaNTD - beta' interaction site [polypeptide binding]; other site 412965000659 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 412965000660 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 412965000661 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 412965000662 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298 412965000663 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412965000664 active site 412965000665 NTP binding site [chemical binding]; other site 412965000666 metal binding triad [ion binding]; metal-binding site 412965000667 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412965000668 probable DNA repair protein; Region: TIGR03623 412965000669 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 412965000670 Predicted GTPase [General function prediction only]; Region: COG0218 412965000671 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 412965000672 G1 box; other site 412965000673 GTP/Mg2+ binding site [chemical binding]; other site 412965000674 Switch I region; other site 412965000675 G2 box; other site 412965000676 G3 box; other site 412965000677 Switch II region; other site 412965000678 G4 box; other site 412965000679 G5 box; other site 412965000680 Cytochrome c; Region: Cytochrom_C; cl11414 412965000681 Cytochrome c; Region: Cytochrom_C; cl11414 412965000682 Cytochrome c; Region: Cytochrom_C; cl11414 412965000683 trigger factor; Provisional; Region: tig; PRK01490 412965000684 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 412965000685 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 412965000686 Clp protease; Region: CLP_protease; pfam00574 412965000687 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 412965000688 oligomer interface [polypeptide binding]; other site 412965000689 active site residues [active] 412965000690 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 412965000691 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 412965000692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000693 Walker A motif; other site 412965000694 ATP binding site [chemical binding]; other site 412965000695 Walker B motif; other site 412965000696 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 412965000697 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 412965000698 Found in ATP-dependent protease La (LON); Region: LON; smart00464 412965000699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965000700 Walker A motif; other site 412965000701 ATP binding site [chemical binding]; other site 412965000702 Walker B motif; other site 412965000703 arginine finger; other site 412965000704 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 412965000705 DsrE/DsrF-like family; Region: DrsE; cl00672 412965000706 multifunctional aminopeptidase A; Provisional; Region: PRK00913 412965000707 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 412965000708 interface (dimer of trimers) [polypeptide binding]; other site 412965000709 Substrate-binding/catalytic site; other site 412965000710 Zn-binding sites [ion binding]; other site 412965000711 Domain of unknown function DUF302; Region: DUF302; cl01364 412965000712 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 412965000713 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412965000714 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 412965000715 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 412965000716 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 412965000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000718 catalytic residue [active] 412965000719 thymidylate kinase; Validated; Region: tmk; PRK00698 412965000720 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 412965000721 TMP-binding site; other site 412965000722 ATP-binding site [chemical binding]; other site 412965000723 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 412965000724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000725 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 412965000726 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 412965000727 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412965000728 inhibitor-cofactor binding pocket; inhibition site 412965000729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000730 catalytic residue [active] 412965000731 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 412965000732 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 412965000733 DsrE/DsrF-like family; Region: DrsE; cl00672 412965000734 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412965000735 CPxP motif; other site 412965000736 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 412965000737 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412965000738 active site 412965000739 dimer interface [polypeptide binding]; other site 412965000740 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 412965000741 active site 412965000742 dimerization interface [polypeptide binding]; other site 412965000743 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 412965000744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965000745 FeS/SAM binding site; other site 412965000746 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 412965000747 feedback inhibition sensing region; other site 412965000748 homohexameric interface [polypeptide binding]; other site 412965000749 nucleotide binding site [chemical binding]; other site 412965000750 N-acetyl-L-glutamate binding site [chemical binding]; other site 412965000751 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 412965000752 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 412965000753 FAD binding pocket [chemical binding]; other site 412965000754 FAD binding motif [chemical binding]; other site 412965000755 phosphate binding motif [ion binding]; other site 412965000756 beta-alpha-beta structure motif; other site 412965000757 NAD binding pocket [chemical binding]; other site 412965000758 Iron coordination center [ion binding]; other site 412965000759 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 412965000760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412965000761 catalytic residue [active] 412965000762 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 412965000763 active site 412965000764 Protein of unknown function; Region: DUF3971; pfam13116 412965000765 AsmA-like C-terminal region; Region: AsmA_2; cl15864 412965000766 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 412965000767 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 412965000768 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 412965000769 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 412965000770 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 412965000771 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 412965000772 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 412965000773 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 412965000774 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 412965000775 putative dimer interface [polypeptide binding]; other site 412965000776 [2Fe-2S] cluster binding site [ion binding]; other site 412965000777 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 412965000778 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 412965000779 SLBB domain; Region: SLBB; pfam10531 412965000780 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 412965000781 NADH dehydrogenase subunit G; Validated; Region: PRK09129 412965000782 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 412965000783 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 412965000784 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965000785 molybdopterin cofactor binding site; other site 412965000786 NADH dehydrogenase; Region: NADHdh; cl00469 412965000787 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 412965000788 4Fe-4S binding domain; Region: Fer4; cl02805 412965000789 4Fe-4S binding domain; Region: Fer4; cl02805 412965000790 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 412965000791 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 412965000792 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 412965000793 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 412965000794 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 412965000795 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 412965000796 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 412965000797 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 412965000798 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 412965000799 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 412965000800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965000801 S-adenosylmethionine binding site [chemical binding]; other site 412965000802 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 412965000803 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 412965000804 intersubunit interface [polypeptide binding]; other site 412965000805 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 412965000806 hinge region; other site 412965000807 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 412965000808 putative nucleotide binding site [chemical binding]; other site 412965000809 uridine monophosphate binding site [chemical binding]; other site 412965000810 homohexameric interface [polypeptide binding]; other site 412965000811 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 412965000812 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 412965000813 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 412965000814 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 412965000815 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 412965000816 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 412965000817 active site 412965000818 substrate binding site [chemical binding]; other site 412965000819 cosubstrate binding site; other site 412965000820 catalytic site [active] 412965000821 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 412965000822 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 412965000823 dimerization interface [polypeptide binding]; other site 412965000824 putative ATP binding site [chemical binding]; other site 412965000825 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 412965000826 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000827 DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420 412965000828 siroheme synthase; Provisional; Region: cysG; PRK10637 412965000829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000830 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 412965000831 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 412965000832 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 412965000833 phosphoserine phosphatase SerB; Region: serB; TIGR00338 412965000834 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 412965000835 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412965000836 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 412965000837 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 412965000838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412965000839 binding surface 412965000840 TPR motif; other site 412965000841 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 412965000842 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 412965000843 metal binding site [ion binding]; metal-binding site 412965000844 dimer interface [polypeptide binding]; other site 412965000845 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 412965000846 Nitrogen regulatory protein P-II; Region: P-II; cl00412 412965000847 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412965000848 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 412965000849 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 412965000850 dihydrodipicolinate synthase; Region: dapA; TIGR00674 412965000851 dimer interface [polypeptide binding]; other site 412965000852 active site 412965000853 catalytic residue [active] 412965000854 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 412965000855 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 412965000856 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 412965000857 nucleotide binding pocket [chemical binding]; other site 412965000858 K-X-D-G motif; other site 412965000859 catalytic site [active] 412965000860 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 412965000861 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 412965000862 Dimer interface [polypeptide binding]; other site 412965000863 Nitrogen regulatory protein P-II; Region: P-II; cl00412 412965000864 Nitrogen regulatory protein P-II; Region: P-II; smart00938 412965000865 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 412965000866 FOG: CBS domain [General function prediction only]; Region: COG0517 412965000867 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 412965000868 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 412965000869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 412965000870 active site 412965000871 phosphorylation site [posttranslational modification] 412965000872 intermolecular recognition site; other site 412965000873 dimerization interface [polypeptide binding]; other site 412965000874 ANTAR domain; Region: ANTAR; cl04297 412965000875 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 412965000876 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 412965000877 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 412965000878 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 412965000879 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 412965000880 glutathione reductase; Validated; Region: PRK06116 412965000881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965000883 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412965000884 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 412965000885 dimer interface [polypeptide binding]; other site 412965000886 putative metal binding site [ion binding]; other site 412965000887 peptide chain release factor 2; Validated; Region: prfB; PRK00578 412965000888 RF-1 domain; Region: RF-1; cl02875 412965000889 RF-1 domain; Region: RF-1; cl02875 412965000890 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 412965000891 16S/18S rRNA binding site [nucleotide binding]; other site 412965000892 S13e-L30e interaction site [polypeptide binding]; other site 412965000893 25S rRNA binding site [nucleotide binding]; other site 412965000894 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 412965000895 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 412965000896 putative acyl-acceptor binding pocket; other site 412965000897 DNA primase, catalytic core; Region: dnaG; TIGR01391 412965000898 CHC2 zinc finger; Region: zf-CHC2; cl15369 412965000899 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 412965000900 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 412965000901 active site 412965000902 metal binding site [ion binding]; metal-binding site 412965000903 interdomain interaction site; other site 412965000904 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 412965000905 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 412965000906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965000907 mraZ protein; Region: TIGR00242 412965000908 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 412965000909 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 412965000910 CAP-like domain; other site 412965000911 active site 412965000912 primary dimer interface [polypeptide binding]; other site 412965000913 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 412965000914 active site 412965000915 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 412965000916 NeuB family; Region: NeuB; cl00496 412965000917 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412965000918 DNA gyrase subunit A; Validated; Region: PRK05560 412965000919 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 412965000920 CAP-like domain; other site 412965000921 active site 412965000922 primary dimer interface [polypeptide binding]; other site 412965000923 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000924 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000925 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000926 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000927 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000928 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 412965000929 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 412965000930 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 412965000931 G1 box; other site 412965000932 putative GEF interaction site [polypeptide binding]; other site 412965000933 GTP/Mg2+ binding site [chemical binding]; other site 412965000934 Switch I region; other site 412965000935 G2 box; other site 412965000936 G3 box; other site 412965000937 Switch II region; other site 412965000938 G4 box; other site 412965000939 G5 box; other site 412965000940 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 412965000941 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 412965000942 catalytic motif [active] 412965000943 Zn binding site [ion binding]; other site 412965000944 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 412965000945 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 412965000946 Mg++ binding site [ion binding]; other site 412965000947 putative catalytic motif [active] 412965000948 putative substrate binding site [chemical binding]; other site 412965000949 ferredoxin; Validated; Region: PRK07118 412965000950 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 412965000951 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 412965000952 homodimer interface [polypeptide binding]; other site 412965000953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965000954 catalytic residue [active] 412965000955 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 412965000956 FAD binding domain; Region: FAD_binding_4; pfam01565 412965000957 FAD binding domain; Region: FAD_binding_4; pfam01565 412965000958 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 412965000959 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 412965000960 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 412965000961 Cysteine-rich domain; Region: CCG; pfam02754 412965000962 Cysteine-rich domain; Region: CCG; pfam02754 412965000963 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 412965000964 TRAM domain; Region: TRAM; cl01282 412965000965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965000966 S-adenosylmethionine binding site [chemical binding]; other site 412965000967 Probable gene remnant. Similar to the central region of beta-hexosaminidase (342 aa) in Shewanella sp. MR-7. 412965000968 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 412965000969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965000970 Family description; Region: UvrD_C_2; cl15862 412965000971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 412965000972 Radical SAM superfamily; Region: Radical_SAM; pfam04055 412965000973 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 412965000974 catalytic residues [active] 412965000975 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 412965000976 ArsC family; Region: ArsC; pfam03960 412965000977 catalytic residues [active] 412965000978 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965000979 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 412965000980 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 412965000981 N-terminal domain interface [polypeptide binding]; other site 412965000982 dimer interface [polypeptide binding]; other site 412965000983 substrate binding pocket (H-site) [chemical binding]; other site 412965000984 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 412965000985 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 412965000986 active site 412965000987 (T/H)XGH motif; other site 412965000988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 412965000989 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 412965000990 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 412965000991 RNA binding surface [nucleotide binding]; other site 412965000992 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 412965000993 active site 412965000994 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 412965000995 Catalytic site [active] 412965000996 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 412965000997 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 412965000998 DNA binding site [nucleotide binding] 412965000999 catalytic residue [active] 412965001000 H2TH interface [polypeptide binding]; other site 412965001001 putative catalytic residues [active] 412965001002 turnover-facilitating residue; other site 412965001003 intercalation triad [nucleotide binding]; other site 412965001004 8OG recognition residue [nucleotide binding]; other site 412965001005 putative reading head residues; other site 412965001006 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 412965001007 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412965001008 Protein of unknown function (DUF989); Region: DUF989; pfam06181 412965001009 Protein of unknown function (DUF989); Region: DUF989; pfam06181 412965001010 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 412965001011 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 412965001012 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 412965001013 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 412965001014 transmembrane helices; other site 412965001015 Type III pantothenate kinase; Region: Pan_kinase; cl09130 412965001016 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 412965001017 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 412965001018 active site 412965001019 HIGH motif; other site 412965001020 dimer interface [polypeptide binding]; other site 412965001021 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965001022 active site 412965001023 KMSKS motif; other site 412965001024 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 412965001025 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 412965001026 RNA binding surface [nucleotide binding]; other site 412965001027 PseudoU_synth_RluB: Pseudouridine synthase, Escherichia coli RluB like. This group is comprised of bacterial and eukaryotic proteins similar to E. coli RluB. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluB; cd02556 412965001028 probable active site [active] 412965001029 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 412965001030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965001031 active site 412965001032 HIGH motif; other site 412965001033 nucleotide binding site [chemical binding]; other site 412965001034 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412965001035 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 412965001036 active site 412965001037 KMSKS motif; other site 412965001038 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 412965001039 tRNA binding surface [nucleotide binding]; other site 412965001040 anticodon binding site; other site 412965001041 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 412965001042 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 412965001043 active site 412965001044 dimer interface [polypeptide binding]; other site 412965001045 metal binding site [ion binding]; metal-binding site 412965001046 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 412965001047 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 412965001048 Amidase; Region: Amidase; cl11426 412965001049 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 412965001050 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 412965001051 GatB domain; Region: GatB_Yqey; cl11497 412965001052 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 412965001053 active site 412965001054 putative substrate binding region [chemical binding]; other site 412965001055 prolyl-tRNA synthetase; Provisional; Region: PRK09194 412965001056 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 412965001057 dimer interface [polypeptide binding]; other site 412965001058 motif 1; other site 412965001059 active site 412965001060 motif 2; other site 412965001061 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 412965001062 putative deacylase active site [active] 412965001063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 412965001064 active site 412965001065 motif 3; other site 412965001066 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 412965001067 anticodon binding site; other site 412965001068 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 412965001069 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 412965001070 Domain of unknown function DUF21; Region: DUF21; pfam01595 412965001071 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412965001072 Transporter associated domain; Region: CorC_HlyC; cl08393 412965001073 enolase; Provisional; Region: eno; PRK00077 412965001074 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 412965001075 dimer interface [polypeptide binding]; other site 412965001076 metal binding site [ion binding]; metal-binding site 412965001077 substrate binding pocket [chemical binding]; other site 412965001078 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 412965001079 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412965001080 Protein export membrane protein; Region: SecD_SecF; cl14618 412965001081 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 412965001082 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 412965001083 G1 box; other site 412965001084 putative GEF interaction site [polypeptide binding]; other site 412965001085 GTP/Mg2+ binding site [chemical binding]; other site 412965001086 Switch I region; other site 412965001087 G2 box; other site 412965001088 G3 box; other site 412965001089 Switch II region; other site 412965001090 G4 box; other site 412965001091 G5 box; other site 412965001092 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 412965001093 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 412965001094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 412965001095 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 412965001096 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 412965001097 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412965001098 substrate binding pocket [chemical binding]; other site 412965001099 chain length determination region; other site 412965001100 substrate-Mg2+ binding site; other site 412965001101 catalytic residues [active] 412965001102 aspartate-rich region 1; other site 412965001103 active site lid residues [active] 412965001104 aspartate-rich region 2; other site 412965001105 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 412965001106 DEAD_2; Region: DEAD_2; pfam06733 412965001107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965001108 Cation transport protein; Region: TrkH; cl10514 412965001109 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 412965001110 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 412965001111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001112 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 412965001113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001114 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 412965001115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412965001116 active site 412965001117 phosphorylation site [posttranslational modification] 412965001118 intermolecular recognition site; other site 412965001119 dimerization interface [polypeptide binding]; other site 412965001120 Helix-turn-helix domains; Region: HTH; cl00088 412965001121 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 412965001122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 412965001123 dimerization interface [polypeptide binding]; other site 412965001124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 412965001125 dimer interface [polypeptide binding]; other site 412965001126 phosphorylation site [posttranslational modification] 412965001127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965001128 ATP binding site [chemical binding]; other site 412965001129 Mg2+ binding site [ion binding]; other site 412965001130 G-X-G motif; other site 412965001131 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 412965001132 dimer interface [polypeptide binding]; other site 412965001133 substrate binding site [chemical binding]; other site 412965001134 metal binding sites [ion binding]; metal-binding site 412965001135 Methyltransferase domain; Region: Methyltransf_31; pfam13847 412965001136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001137 S-adenosylmethionine binding site [chemical binding]; other site 412965001138 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 412965001139 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 412965001140 active site 412965001141 (T/H)XGH motif; other site 412965001142 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 412965001143 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 412965001144 chaperone protein DnaJ; Provisional; Region: PRK10767 412965001145 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 412965001146 HSP70 interaction site [polypeptide binding]; other site 412965001147 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 412965001148 substrate binding site [polypeptide binding]; other site 412965001149 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 412965001150 Zn binding sites [ion binding]; other site 412965001151 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 412965001152 dimer interface [polypeptide binding]; other site 412965001153 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 412965001154 RuvA N terminal domain; Region: RuvA_N; pfam01330 412965001155 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 412965001156 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 412965001157 substrate binding site [chemical binding]; other site 412965001158 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 412965001159 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 412965001160 substrate binding site [chemical binding]; other site 412965001161 ligand binding site [chemical binding]; other site 412965001162 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 412965001163 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 412965001164 active site 412965001165 dimer interface [polypeptide binding]; other site 412965001166 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 412965001167 Ligand Binding Site [chemical binding]; other site 412965001168 Molecular Tunnel; other site 412965001169 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 412965001170 RNA/DNA hybrid binding site [nucleotide binding]; other site 412965001171 active site 412965001172 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 412965001173 putative coenzyme Q binding site [chemical binding]; other site 412965001174 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 412965001175 SmpB-tmRNA interface; other site 412965001176 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 412965001177 active site 412965001178 multimer interface [polypeptide binding]; other site 412965001179 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 412965001180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001181 FeS/SAM binding site; other site 412965001182 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 412965001183 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412965001184 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 412965001185 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 412965001186 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 412965001187 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 412965001188 TPP-binding site; other site 412965001189 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 412965001190 PYR/PP interface [polypeptide binding]; other site 412965001191 dimer interface [polypeptide binding]; other site 412965001192 TPP binding site [chemical binding]; other site 412965001193 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 412965001194 putative protease; Provisional; Region: PRK15452 412965001195 Peptidase family U32; Region: Peptidase_U32; cl03113 412965001196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001197 S-adenosylmethionine binding site [chemical binding]; other site 412965001198 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 412965001199 putative GSH binding site [chemical binding]; other site 412965001200 catalytic residues [active] 412965001201 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 412965001202 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 412965001203 dimerization interface [polypeptide binding]; other site 412965001204 ATP binding site [chemical binding]; other site 412965001205 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 412965001206 dimerization interface [polypeptide binding]; other site 412965001207 ATP binding site [chemical binding]; other site 412965001208 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 412965001209 putative active site [active] 412965001210 catalytic triad [active] 412965001211 Transcriptional regulator; Region: Transcrip_reg; cl00361 412965001212 Quinolinate synthetase A protein; Region: NadA; cl00420 412965001213 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 412965001214 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 412965001215 dimer interface [polypeptide binding]; other site 412965001216 anticodon binding site; other site 412965001217 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 412965001218 homodimer interface [polypeptide binding]; other site 412965001219 motif 1; other site 412965001220 active site 412965001221 motif 2; other site 412965001222 GAD domain; Region: GAD; pfam02938 412965001223 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 412965001224 active site 412965001225 motif 3; other site 412965001226 Protein of unknown function (DUF502); Region: DUF502; cl01107 412965001227 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 412965001228 active site 412965001229 Peptidase family M48; Region: Peptidase_M48; cl12018 412965001230 LemA family; Region: LemA; cl00742 412965001231 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 412965001232 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 412965001233 active site 412965001234 substrate binding site [chemical binding]; other site 412965001235 catalytic site [active] 412965001236 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 412965001237 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 412965001238 dimer interface [polypeptide binding]; other site 412965001239 allosteric magnesium binding site [ion binding]; other site 412965001240 active site 412965001241 aspartate-rich active site metal binding site; other site 412965001242 Schiff base residues; other site 412965001243 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 412965001244 ThiC-associated domain; Region: ThiC-associated; pfam13667 412965001245 ThiC family; Region: ThiC; cl08031 412965001246 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 412965001247 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 412965001248 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 412965001249 GTPase CgtA; Reviewed; Region: obgE; PRK12299 412965001250 GTP1/OBG; Region: GTP1_OBG; pfam01018 412965001251 Obg GTPase; Region: Obg; cd01898 412965001252 G1 box; other site 412965001253 GTP/Mg2+ binding site [chemical binding]; other site 412965001254 Switch I region; other site 412965001255 G2 box; other site 412965001256 G3 box; other site 412965001257 Switch II region; other site 412965001258 G4 box; other site 412965001259 G5 box; other site 412965001260 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 412965001261 nucleotide binding site [chemical binding]; other site 412965001262 homotetrameric interface [polypeptide binding]; other site 412965001263 putative phosphate binding site [ion binding]; other site 412965001264 putative allosteric binding site; other site 412965001265 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 412965001266 catalytic center binding site [active] 412965001267 ATP binding site [chemical binding]; other site 412965001268 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 412965001269 oligomerization interface [polypeptide binding]; other site 412965001270 active site 412965001271 metal binding site [ion binding]; metal-binding site 412965001272 pantoate--beta-alanine ligase; Region: panC; TIGR00018 412965001273 Pantoate-beta-alanine ligase; Region: PanC; cd00560 412965001274 active site 412965001275 ATP-binding site [chemical binding]; other site 412965001276 pantoate-binding site; other site 412965001277 HXXH motif; other site 412965001278 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965001279 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 412965001280 NifU-like domain; Region: NifU; cl00484 412965001281 thiamine monophosphate kinase; Provisional; Region: PRK05731 412965001282 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 412965001283 ATP binding site [chemical binding]; other site 412965001284 dimerization interface [polypeptide binding]; other site 412965001285 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 412965001286 haloacid dehalogenase-like hydrolase family protein; Region: PLN02779 412965001287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965001288 motif II; other site 412965001289 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 412965001290 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 412965001291 tetramer interface [polypeptide binding]; other site 412965001292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001293 catalytic residue [active] 412965001294 isocitrate dehydrogenase; Validated; Region: PRK07362 412965001295 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 412965001296 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 412965001297 aspartate aminotransferase; Provisional; Region: PRK05764 412965001298 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412965001299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001300 homodimer interface [polypeptide binding]; other site 412965001301 catalytic residue [active] 412965001302 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 412965001303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001304 FeS/SAM binding site; other site 412965001305 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 412965001306 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 412965001307 Tetramer interface [polypeptide binding]; other site 412965001308 active site 412965001309 FMN-binding site [chemical binding]; other site 412965001310 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 412965001311 active site 412965001312 dimer interface [polypeptide binding]; other site 412965001313 hypothetical protein; Provisional; Region: PRK09126 412965001314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001315 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 412965001316 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 412965001317 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 412965001318 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 412965001319 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 412965001320 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 412965001321 shikimate binding site; other site 412965001322 NAD(P) binding site [chemical binding]; other site 412965001323 ribonuclease E; Reviewed; Region: rne; PRK10811 412965001324 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 412965001325 homodimer interface [polypeptide binding]; other site 412965001326 oligonucleotide binding site [chemical binding]; other site 412965001327 pteridine reductase; Provisional; Region: PRK09135 412965001328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001329 NAD(P) binding site [chemical binding]; other site 412965001330 active site 412965001331 Uncharacterized conserved protein [Function unknown]; Region: COG1565 412965001332 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 412965001333 Bacitracin resistance protein BacA; Region: BacA; cl00858 412965001334 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 412965001335 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 412965001336 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 412965001337 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 412965001338 PYR/PP interface [polypeptide binding]; other site 412965001339 dimer interface [polypeptide binding]; other site 412965001340 TPP binding site [chemical binding]; other site 412965001341 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 412965001342 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 412965001343 TPP-binding site [chemical binding]; other site 412965001344 dimer interface [polypeptide binding]; other site 412965001345 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 412965001346 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 412965001347 putative valine binding site [chemical binding]; other site 412965001348 dimer interface [polypeptide binding]; other site 412965001349 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 412965001350 ketol-acid reductoisomerase; Provisional; Region: PRK05479 412965001351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001352 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 412965001353 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 412965001354 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 412965001355 2-isopropylmalate synthase; Validated; Region: PRK00915 412965001356 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 412965001357 active site 412965001358 catalytic residues [active] 412965001359 metal binding site [ion binding]; metal-binding site 412965001360 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 412965001361 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 412965001362 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 412965001363 ornithine carbamoyltransferase; Provisional; Region: PRK00779 412965001364 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 412965001365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001366 acetylornithine aminotransferase; Provisional; Region: PRK02627 412965001367 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 412965001368 inhibitor-cofactor binding pocket; inhibition site 412965001369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001370 catalytic residue [active] 412965001371 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 412965001372 30S subunit binding site; other site 412965001373 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 412965001374 MgtE intracellular N domain; Region: MgtE_N; cl15244 412965001375 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 412965001376 Divalent cation transporter; Region: MgtE; cl00786 412965001377 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 412965001378 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 412965001379 active site 412965001380 substrate binding site [chemical binding]; other site 412965001381 metal binding site [ion binding]; metal-binding site 412965001382 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 412965001383 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 412965001384 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 412965001385 dimer interface [polypeptide binding]; other site 412965001386 TPP-binding site [chemical binding]; other site 412965001387 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 412965001388 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 412965001389 RNase E interface [polypeptide binding]; other site 412965001390 trimer interface [polypeptide binding]; other site 412965001391 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 412965001392 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 412965001393 RNase E interface [polypeptide binding]; other site 412965001394 trimer interface [polypeptide binding]; other site 412965001395 active site 412965001396 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 412965001397 putative nucleic acid binding region [nucleotide binding]; other site 412965001398 G-X-X-G motif; other site 412965001399 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 412965001400 RNA binding site [nucleotide binding]; other site 412965001401 domain interface; other site 412965001402 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 412965001403 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 412965001404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 412965001405 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 412965001406 active site 412965001407 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 412965001408 Bacterial SH3 domain; Region: SH3_3; cl02551 412965001409 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 412965001410 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965001411 active site 412965001412 HIGH motif; other site 412965001413 nucleotide binding site [chemical binding]; other site 412965001414 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 412965001415 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 412965001416 active site 412965001417 KMSKS motif; other site 412965001418 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 412965001419 tRNA binding surface [nucleotide binding]; other site 412965001420 anticodon binding site; other site 412965001421 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 412965001422 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14969 412965001423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965001424 Walker A motif; other site 412965001425 ATP binding site [chemical binding]; other site 412965001426 Walker B motif; other site 412965001427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965001428 arginine finger; other site 412965001429 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 412965001430 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 412965001431 homodimer interface [polypeptide binding]; other site 412965001432 substrate-cofactor binding pocket; other site 412965001433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965001434 catalytic residue [active] 412965001435 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 412965001436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 412965001437 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 412965001438 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 412965001439 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 412965001440 Sel1 repeat; Region: Sel1; cl02723 412965001441 Sel1 repeat; Region: Sel1; cl02723 412965001442 Sel1 repeat; Region: Sel1; cl02723 412965001443 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 412965001444 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412965001445 HIGH motif; other site 412965001446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 412965001447 active site 412965001448 KMSKS motif; other site 412965001449 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 412965001450 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 412965001451 metal binding triad; other site 412965001452 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 412965001453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 412965001454 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 412965001455 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 412965001456 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412965001457 catalytic residues [active] 412965001458 transcription termination factor Rho; Provisional; Region: rho; PRK09376 412965001459 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 412965001460 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 412965001461 RNA binding site [nucleotide binding]; other site 412965001462 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 412965001463 multimer interface [polypeptide binding]; other site 412965001464 Walker A motif; other site 412965001465 ATP binding site [chemical binding]; other site 412965001466 Walker B motif; other site 412965001467 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412965001468 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 412965001469 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 412965001470 poly(A) polymerase; Region: pcnB; TIGR01942 412965001471 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 412965001472 active site 412965001473 NTP binding site [chemical binding]; other site 412965001474 metal binding triad [ion binding]; metal-binding site 412965001475 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 412965001476 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 412965001477 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 412965001478 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 412965001479 substrate binding pocket [chemical binding]; other site 412965001480 chain length determination region; other site 412965001481 substrate-Mg2+ binding site; other site 412965001482 catalytic residues [active] 412965001483 aspartate-rich region 1; other site 412965001484 active site lid residues [active] 412965001485 aspartate-rich region 2; other site 412965001486 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 412965001487 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 412965001488 dimer interface [polypeptide binding]; other site 412965001489 active site 412965001490 CoA binding pocket [chemical binding]; other site 412965001491 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 412965001492 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 412965001493 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 412965001494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 412965001495 putative acyl-acceptor binding pocket; other site 412965001496 short chain dehydrogenase; Provisional; Region: PRK08703 412965001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001498 NAD(P) binding site [chemical binding]; other site 412965001499 active site 412965001500 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 412965001501 active site 412965001502 dimerization interface [polypeptide binding]; other site 412965001503 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 412965001504 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 412965001505 heat shock protein 90; Provisional; Region: PRK05218 412965001506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 412965001507 Phage maturation protein; Region: Phage_mat-A; pfam03863 412965001508 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 412965001509 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 412965001510 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 412965001511 CPxP motif; other site 412965001512 glutamine synthetase; Provisional; Region: glnA; PRK09469 412965001513 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 412965001514 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 412965001515 biotin synthase; Region: bioB; TIGR00433 412965001516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965001517 FeS/SAM binding site; other site 412965001518 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 412965001519 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 412965001520 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 412965001521 active site 412965001522 homodimer interface [polypeptide binding]; other site 412965001523 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 412965001524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965001525 Walker A/P-loop; other site 412965001526 ATP binding site [chemical binding]; other site 412965001527 Q-loop/lid; other site 412965001528 ABC transporter signature motif; other site 412965001529 Walker B; other site 412965001530 D-loop; other site 412965001531 H-loop/switch region; other site 412965001532 ABC transporter; Region: ABC_tran_2; pfam12848 412965001533 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 412965001534 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 412965001535 Lumazine binding domain; Region: Lum_binding; pfam00677 412965001536 Lumazine binding domain; Region: Lum_binding; pfam00677 412965001537 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 412965001538 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 412965001539 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 412965001540 dimerization interface [polypeptide binding]; other site 412965001541 active site 412965001542 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 412965001543 homopentamer interface [polypeptide binding]; other site 412965001544 active site 412965001545 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 412965001546 putative RNA binding site [nucleotide binding]; other site 412965001547 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 412965001548 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 412965001549 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 412965001550 substrate binding pocket [chemical binding]; other site 412965001551 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 412965001552 B12 binding site [chemical binding]; other site 412965001553 cobalt ligand [ion binding]; other site 412965001554 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 412965001555 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 412965001556 dimer interface [polypeptide binding]; other site 412965001557 ssDNA binding site [nucleotide binding]; other site 412965001558 tetramer (dimer of dimers) interface [polypeptide binding]; other site 412965001559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965001560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 412965001561 putative substrate translocation pore; other site 412965001562 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 412965001563 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 412965001564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 412965001565 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 412965001566 synthetase active site [active] 412965001567 NTP binding site [chemical binding]; other site 412965001568 metal binding site [ion binding]; metal-binding site 412965001569 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 412965001570 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 412965001571 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 412965001572 translocation protein TolB; Provisional; Region: tolB; PRK04922 412965001573 TolB amino-terminal domain; Region: TolB_N; cl00639 412965001574 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412965001575 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 412965001576 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 412965001577 ligand binding site [chemical binding]; other site 412965001578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 412965001579 hypothetical protein; Validated; Region: PRK09070 412965001580 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412965001581 chorismate binding enzyme; Region: Chorismate_bind; cl10555 412965001582 NAD synthetase; Provisional; Region: PRK13981 412965001583 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 412965001584 multimer interface [polypeptide binding]; other site 412965001585 active site 412965001586 catalytic triad [active] 412965001587 protein interface 1 [polypeptide binding]; other site 412965001588 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 412965001589 homodimer interface [polypeptide binding]; other site 412965001590 NAD binding pocket [chemical binding]; other site 412965001591 ATP binding pocket [chemical binding]; other site 412965001592 Mg binding site [ion binding]; other site 412965001593 active-site loop [active] 412965001594 Ferrochelatase; Region: Ferrochelatase; pfam00762 412965001595 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 412965001596 C-terminal domain interface [polypeptide binding]; other site 412965001597 active site 412965001598 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 412965001599 active site 412965001600 N-terminal domain interface [polypeptide binding]; other site 412965001601 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 412965001602 ATP cone domain; Region: ATP-cone; pfam03477 412965001603 Class I ribonucleotide reductase; Region: RNR_I; cd01679 412965001604 active site 412965001605 dimer interface [polypeptide binding]; other site 412965001606 catalytic residues [active] 412965001607 effector binding site; other site 412965001608 R2 peptide binding site; other site 412965001609 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 412965001610 dimer interface [polypeptide binding]; other site 412965001611 putative radical transfer pathway; other site 412965001612 diiron center [ion binding]; other site 412965001613 tyrosyl radical; other site 412965001614 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412965001615 catalytic loop [active] 412965001616 iron binding site [ion binding]; other site 412965001617 dUTPase; Region: dUTPase_2; pfam08761 412965001618 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 412965001619 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 412965001620 dimer interface [polypeptide binding]; other site 412965001621 putative active site [active] 412965001622 putative substrate binding site [chemical binding]; other site 412965001623 catalytic site [active] 412965001624 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 412965001625 Dehydratase family; Region: ILVD_EDD; cl00340 412965001626 ribonuclease R; Region: RNase_R; TIGR02063 412965001627 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412965001628 RNB domain; Region: RNB; pfam00773 412965001629 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 412965001630 RNA binding site [nucleotide binding]; other site 412965001631 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 412965001632 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 412965001633 GDP-binding site [chemical binding]; other site 412965001634 ACT binding site; other site 412965001635 IMP binding site; other site 412965001636 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 412965001637 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 412965001638 dimer interface [polypeptide binding]; other site 412965001639 motif 1; other site 412965001640 active site 412965001641 motif 2; other site 412965001642 motif 3; other site 412965001643 HflC protein; Region: hflC; TIGR01932 412965001644 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 412965001645 HflK protein; Region: hflK; TIGR01933 412965001646 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 412965001647 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 412965001648 Organic solvent tolerance protein; Region: OstA_C; pfam04453 412965001649 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 412965001650 PPIC-type PPIASE domain; Region: Rotamase; cl08278 412965001651 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 412965001652 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 412965001653 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 412965001654 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 412965001655 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 412965001656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965001657 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 412965001658 Walker A motif; other site 412965001659 ATP binding site [chemical binding]; other site 412965001660 Walker B motif; other site 412965001661 arginine finger; other site 412965001662 Protein of unknown function (DUF493); Region: DUF493; cl01102 412965001663 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 412965001664 lipoyl synthase; Provisional; Region: PRK05481 412965001665 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 412965001666 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 412965001667 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 412965001668 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 412965001669 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 412965001670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001671 Protein of unknown function (DUF525); Region: DUF525; cl01119 412965001672 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 412965001673 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 412965001674 active site 412965001675 metal binding site [ion binding]; metal-binding site 412965001676 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 412965001677 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 412965001678 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 412965001679 zinc metallopeptidase RseP; Provisional; Region: PRK10779 412965001680 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 412965001681 active site 412965001682 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412965001683 protein binding site [polypeptide binding]; other site 412965001684 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 412965001685 protein binding site [polypeptide binding]; other site 412965001686 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 412965001687 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 412965001688 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 412965001689 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 412965001690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 412965001691 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 412965001692 Surface antigen; Region: Bac_surface_Ag; cl03097 412965001693 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 412965001694 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 412965001695 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 412965001696 trimer interface [polypeptide binding]; other site 412965001697 active site 412965001698 UDP-GlcNAc binding site [chemical binding]; other site 412965001699 lipid binding site [chemical binding]; lipid-binding site 412965001700 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 412965001701 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 412965001702 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 412965001703 active site 412965001704 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 412965001705 MatE; Region: MatE; cl10513 412965001706 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 412965001707 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 412965001708 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 412965001709 catalytic site [active] 412965001710 G-X2-G-X-G-K; other site 412965001711 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 412965001712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 412965001713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 412965001714 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 412965001715 oligomerisation interface [polypeptide binding]; other site 412965001716 mobile loop; other site 412965001717 roof hairpin; other site 412965001718 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 412965001719 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 412965001720 ring oligomerisation interface [polypeptide binding]; other site 412965001721 ATP/Mg binding site [chemical binding]; other site 412965001722 stacking interactions; other site 412965001723 hinge regions; other site 412965001724 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 412965001725 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 412965001726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965001727 ATP binding site [chemical binding]; other site 412965001728 Mg2+ binding site [ion binding]; other site 412965001729 G-X-G motif; other site 412965001730 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 412965001731 anchoring element; other site 412965001732 dimer interface [polypeptide binding]; other site 412965001733 ATP binding site [chemical binding]; other site 412965001734 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 412965001735 active site 412965001736 putative metal-binding site [ion binding]; other site 412965001737 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 412965001738 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 412965001739 Ligand Binding Site [chemical binding]; other site 412965001740 Phosphopantetheine attachment site; Region: PP-binding; cl09936 412965001741 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412965001742 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 412965001743 dimer interface [polypeptide binding]; other site 412965001744 active site 412965001745 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 412965001746 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 412965001747 active site 412965001748 Zn binding site [ion binding]; other site 412965001749 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 412965001750 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 412965001751 active site 412965001752 HIGH motif; other site 412965001753 KMSKS motif; other site 412965001754 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 412965001755 tRNA binding surface [nucleotide binding]; other site 412965001756 anticodon binding site; other site 412965001757 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 412965001758 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 412965001759 Walker A motif; other site 412965001760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 412965001761 catalytic loop [active] 412965001762 iron binding site [ion binding]; other site 412965001763 chaperone protein HscA; Provisional; Region: hscA; PRK05183 412965001764 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 412965001765 co-chaperone HscB; Provisional; Region: hscB; PRK05014 412965001766 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 412965001767 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 412965001768 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965001769 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 412965001770 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 412965001771 trimerization site [polypeptide binding]; other site 412965001772 active site 412965001773 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412965001774 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 412965001775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965001776 catalytic residue [active] 412965001777 Helix-turn-helix domains; Region: HTH; cl00088 412965001778 Rrf2 family protein; Region: rrf2_super; TIGR00738 412965001779 serine O-acetyltransferase; Region: cysE; TIGR01172 412965001780 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 412965001781 trimer interface [polypeptide binding]; other site 412965001782 active site 412965001783 substrate binding site [chemical binding]; other site 412965001784 CoA binding site [chemical binding]; other site 412965001785 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 412965001786 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 412965001787 putative acyl-acceptor binding pocket; other site 412965001788 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 412965001789 Ligand Binding Site [chemical binding]; other site 412965001790 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 412965001791 shikimate kinase; Reviewed; Region: aroK; PRK00131 412965001792 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 412965001793 ADP binding site [chemical binding]; other site 412965001794 magnesium binding site [ion binding]; other site 412965001795 putative shikimate binding site; other site 412965001796 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 412965001797 homodimer interface [polypeptide binding]; other site 412965001798 substrate-cofactor binding pocket; other site 412965001799 catalytic residue [active] 412965001800 aspartate kinase; Reviewed; Region: PRK06635 412965001801 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 412965001802 putative nucleotide binding site [chemical binding]; other site 412965001803 putative catalytic residues [active] 412965001804 putative Mg ion binding site [ion binding]; other site 412965001805 putative aspartate binding site [chemical binding]; other site 412965001806 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 412965001807 putative allosteric regulatory site; other site 412965001808 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 412965001809 Peptidase family M48; Region: Peptidase_M48; cl12018 412965001810 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 412965001811 RNA binding site [nucleotide binding]; other site 412965001812 homodimer interface [polypeptide binding]; other site 412965001813 GTPase RsgA; Reviewed; Region: PRK00098 412965001814 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 412965001815 GTPase/Zn-binding domain interface [polypeptide binding]; other site 412965001816 GTP/Mg2+ binding site [chemical binding]; other site 412965001817 G4 box; other site 412965001818 G5 box; other site 412965001819 G1 box; other site 412965001820 Switch I region; other site 412965001821 G2 box; other site 412965001822 G3 box; other site 412965001823 Switch II region; other site 412965001824 Protein of unknown function (DUF423); Region: DUF423; cl01008 412965001825 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412965001826 IHF - DNA interface [nucleotide binding]; other site 412965001827 IHF dimer interface [polypeptide binding]; other site 412965001828 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 412965001829 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 412965001830 RNA binding site [nucleotide binding]; other site 412965001831 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 412965001832 RNA binding site [nucleotide binding]; other site 412965001833 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 412965001834 RNA binding site [nucleotide binding]; other site 412965001835 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412965001836 RNA binding site [nucleotide binding]; other site 412965001837 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 412965001838 RNA binding site [nucleotide binding]; other site 412965001839 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec6; cd05691 412965001840 RNA binding site [nucleotide binding]; other site 412965001841 cytidylate kinase; Provisional; Region: cmk; PRK00023 412965001842 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 412965001843 CMP-binding site; other site 412965001844 The sites determining sugar specificity; other site 412965001845 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 412965001846 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 412965001847 dimer interface [polypeptide binding]; other site 412965001848 putative anticodon binding site; other site 412965001849 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 412965001850 motif 1; other site 412965001851 active site 412965001852 motif 2; other site 412965001853 motif 3; other site 412965001854 Cytochrome C biogenesis protein; Region: CcmH; cl01179 412965001855 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 412965001856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965001857 Walker A/P-loop; other site 412965001858 ATP binding site [chemical binding]; other site 412965001859 Q-loop/lid; other site 412965001860 ABC transporter signature motif; other site 412965001861 Walker B; other site 412965001862 D-loop; other site 412965001863 H-loop/switch region; other site 412965001864 ABC transporter; Region: ABC_tran_2; pfam12848 412965001865 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 412965001866 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 412965001867 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 412965001868 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 412965001869 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 412965001870 hinge; other site 412965001871 active site 412965001872 ATP phosphoribosyltransferase; Region: HisG; cl15266 412965001873 histidinol dehydrogenase; Region: hisD; TIGR00069 412965001874 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 412965001875 NAD binding site [chemical binding]; other site 412965001876 dimerization interface [polypeptide binding]; other site 412965001877 product binding site; other site 412965001878 substrate binding site [chemical binding]; other site 412965001879 zinc binding site [ion binding]; other site 412965001880 catalytic residues [active] 412965001881 signal recognition particle protein; Provisional; Region: PRK10867 412965001882 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 412965001883 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412965001884 P loop; other site 412965001885 GTP binding site [chemical binding]; other site 412965001886 Signal peptide binding domain; Region: SRP_SPB; pfam02978 412965001887 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412965001888 GTP-binding protein LepA; Provisional; Region: PRK05433 412965001889 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 412965001890 G1 box; other site 412965001891 putative GEF interaction site [polypeptide binding]; other site 412965001892 GTP/Mg2+ binding site [chemical binding]; other site 412965001893 Switch I region; other site 412965001894 G2 box; other site 412965001895 G3 box; other site 412965001896 Switch II region; other site 412965001897 G4 box; other site 412965001898 G5 box; other site 412965001899 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 412965001900 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 412965001901 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 412965001902 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 412965001903 catalytic triad [active] 412965001904 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 412965001905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965001906 S-adenosylmethionine binding site [chemical binding]; other site 412965001907 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 412965001908 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 412965001909 active site 412965001910 hydrophilic channel; other site 412965001911 dimerization interface [polypeptide binding]; other site 412965001912 catalytic residues [active] 412965001913 active site lid [active] 412965001914 GTPase Era; Reviewed; Region: era; PRK00089 412965001915 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 412965001916 G1 box; other site 412965001917 GTP/Mg2+ binding site [chemical binding]; other site 412965001918 Switch I region; other site 412965001919 G2 box; other site 412965001920 Switch II region; other site 412965001921 G3 box; other site 412965001922 G4 box; other site 412965001923 G5 box; other site 412965001924 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 412965001925 ribonuclease III; Reviewed; Region: rnc; PRK00102 412965001926 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 412965001927 dimerization interface [polypeptide binding]; other site 412965001928 active site 412965001929 metal binding site [ion binding]; metal-binding site 412965001930 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 412965001931 dsRNA binding site [nucleotide binding]; other site 412965001932 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09733 412965001933 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 412965001934 dimerization interface [polypeptide binding]; other site 412965001935 active site 412965001936 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 412965001937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 412965001938 dimerization interface [polypeptide binding]; other site 412965001939 putative DNA binding site [nucleotide binding]; other site 412965001940 putative Zn2+ binding site [ion binding]; other site 412965001941 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 412965001942 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 412965001943 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 412965001944 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 412965001945 protein binding site [polypeptide binding]; other site 412965001946 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 412965001947 Catalytic dyad [active] 412965001948 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412965001949 Catalytic site [active] 412965001950 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 412965001951 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 412965001952 DsrC like protein; Region: DsrC; cl01101 412965001953 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 412965001954 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 412965001955 hinge; other site 412965001956 active site 412965001957 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 412965001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412965001960 Chorismate mutase type II; Region: CM_2; cl00693 412965001961 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 412965001962 Prephenate dehydratase; Region: PDT; pfam00800 412965001963 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 412965001964 putative L-Phe binding site [chemical binding]; other site 412965001965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965001966 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 412965001967 L-serine binding site [chemical binding]; other site 412965001968 ACT domain interface; other site 412965001969 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412965001970 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965001971 catalytic residue [active] 412965001972 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 412965001973 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 412965001974 homodimer interface [polypeptide binding]; other site 412965001975 Walker A motif; other site 412965001976 ATP binding site [chemical binding]; other site 412965001977 hydroxycobalamin binding site [chemical binding]; other site 412965001978 Walker B motif; other site 412965001979 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 412965001980 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 412965001981 dimer interface [polypeptide binding]; other site 412965001982 glycine-pyridoxal phosphate binding site [chemical binding]; other site 412965001983 active site 412965001984 folate binding site [chemical binding]; other site 412965001985 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 412965001986 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 412965001987 ATP binding site [chemical binding]; other site 412965001988 substrate interface [chemical binding]; other site 412965001989 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 412965001990 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412965001991 IHF dimer interface [polypeptide binding]; other site 412965001992 IHF - DNA interface [nucleotide binding]; other site 412965001993 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 412965001994 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 412965001995 putative tRNA-binding site [nucleotide binding]; other site 412965001996 B3/4 domain; Region: B3_4; cl11458 412965001997 tRNA synthetase B5 domain; Region: B5; cl08394 412965001998 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 412965001999 dimer interface [polypeptide binding]; other site 412965002000 motif 1; other site 412965002001 motif 3; other site 412965002002 motif 2; other site 412965002003 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 412965002004 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 412965002005 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 412965002006 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 412965002007 dimer interface [polypeptide binding]; other site 412965002008 motif 1; other site 412965002009 active site 412965002010 motif 2; other site 412965002011 motif 3; other site 412965002012 ribosomal protein L20; Region: rpl20; CHL00068 412965002013 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 412965002014 23S rRNA binding site [nucleotide binding]; other site 412965002015 L21 binding site [polypeptide binding]; other site 412965002016 L13 binding site [polypeptide binding]; other site 412965002017 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 412965002018 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 412965002019 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 412965002020 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 412965002021 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 412965002022 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 412965002023 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 412965002024 active site 412965002025 dimer interface [polypeptide binding]; other site 412965002026 motif 1; other site 412965002027 motif 2; other site 412965002028 motif 3; other site 412965002029 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 412965002030 anticodon binding site; other site 412965002031 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 412965002032 DHH family; Region: DHH; pfam01368 412965002033 DHHA1 domain; Region: DHHA1; pfam02272 412965002034 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 412965002035 FAD binding domain; Region: FAD_binding_3; pfam01494 412965002036 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 412965002037 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 412965002038 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 412965002039 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 412965002040 NAD binding site [chemical binding]; other site 412965002041 homotetramer interface [polypeptide binding]; other site 412965002042 homodimer interface [polypeptide binding]; other site 412965002043 substrate binding site [chemical binding]; other site 412965002044 active site 412965002045 periplasmic folding chaperone; Provisional; Region: PRK10788 412965002046 SurA N-terminal domain; Region: SurA_N_3; cl07813 412965002047 PPIC-type PPIASE domain; Region: Rotamase; cl08278 412965002048 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 412965002049 IHF dimer interface [polypeptide binding]; other site 412965002050 IHF - DNA interface [nucleotide binding]; other site 412965002051 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 412965002052 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 412965002053 catalytic residues [active] 412965002054 central insert; other site 412965002055 CcmE; Region: CcmE; cl00994 412965002056 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 412965002057 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 412965002058 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 412965002059 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 412965002060 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 412965002061 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 412965002062 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 412965002063 replicative DNA helicase; Region: DnaB; TIGR00665 412965002064 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 412965002065 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 412965002066 Walker A motif; other site 412965002067 ATP binding site [chemical binding]; other site 412965002068 Walker B motif; other site 412965002069 DNA binding loops [nucleotide binding] 412965002070 alanine racemase; Reviewed; Region: alr; PRK00053 412965002071 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 412965002072 active site 412965002073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 412965002074 substrate binding site [chemical binding]; other site 412965002075 catalytic residues [active] 412965002076 dimer interface [polypeptide binding]; other site 412965002077 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 412965002078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 412965002079 active site 412965002080 metal binding site [ion binding]; metal-binding site 412965002081 hexamer interface [polypeptide binding]; other site 412965002082 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 412965002083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 412965002084 TPR motif; other site 412965002085 TPR repeat; Region: TPR_11; pfam13414 412965002086 binding surface 412965002087 Protein of unknown function (DUF971); Region: DUF971; cl01414 412965002088 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 412965002089 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 412965002090 dimer interface [polypeptide binding]; other site 412965002091 motif 1; other site 412965002092 active site 412965002093 motif 2; other site 412965002094 motif 3; other site 412965002095 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 412965002096 anticodon binding site; other site 412965002097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 412965002098 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 412965002099 GTP-binding protein Der; Reviewed; Region: PRK00093 412965002100 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 412965002101 G1 box; other site 412965002102 GTP/Mg2+ binding site [chemical binding]; other site 412965002103 Switch I region; other site 412965002104 G2 box; other site 412965002105 Switch II region; other site 412965002106 G3 box; other site 412965002107 G4 box; other site 412965002108 G5 box; other site 412965002109 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 412965002110 G1 box; other site 412965002111 GTP/Mg2+ binding site [chemical binding]; other site 412965002112 Switch I region; other site 412965002113 G2 box; other site 412965002114 G3 box; other site 412965002115 Switch II region; other site 412965002116 G4 box; other site 412965002117 G5 box; other site 412965002118 CTP synthetase; Validated; Region: pyrG; PRK05380 412965002119 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 412965002120 Catalytic site [active] 412965002121 active site 412965002122 UTP binding site [chemical binding]; other site 412965002123 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 412965002124 active site 412965002125 putative oxyanion hole; other site 412965002126 catalytic triad [active] 412965002127 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 412965002128 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 412965002129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002130 Walker A/P-loop; other site 412965002131 ATP binding site [chemical binding]; other site 412965002132 Q-loop/lid; other site 412965002133 ABC transporter signature motif; other site 412965002134 Walker B; other site 412965002135 D-loop; other site 412965002136 H-loop/switch region; other site 412965002137 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965002138 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 412965002139 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965002140 Cysteine dioxygenase type I; Region: CDO_I; cl15835 412965002141 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412965002142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965002143 catalytic residue [active] 412965002144 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 412965002145 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 412965002146 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 412965002147 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 412965002148 iron-sulfur cluster [ion binding]; other site 412965002149 [2Fe-2S] cluster binding site [ion binding]; other site 412965002150 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 412965002151 N-acetyl-D-glucosamine binding site [chemical binding]; other site 412965002152 catalytic residue [active] 412965002153 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 412965002154 DNA-binding site [nucleotide binding]; DNA binding site 412965002155 RNA-binding motif; other site 412965002156 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965002157 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 412965002158 ligand binding site [chemical binding]; other site 412965002159 active site 412965002160 UGI interface [polypeptide binding]; other site 412965002161 catalytic site [active] 412965002162 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 412965002163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002164 Domain of unknown function (DUF3410); Region: DUF3410; pfam11890 412965002165 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 412965002166 active site 412965002167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 412965002168 active site 412965002169 ATP binding site [chemical binding]; other site 412965002170 substrate binding site [chemical binding]; other site 412965002171 activation loop (A-loop); other site 412965002172 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 412965002173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965002174 putative substrate translocation pore; other site 412965002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 412965002176 putative substrate translocation pore; other site 412965002177 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 412965002178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965002179 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412965002180 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 412965002181 MoaE homodimer interface [polypeptide binding]; other site 412965002182 MoaD interaction [polypeptide binding]; other site 412965002183 active site residues [active] 412965002184 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 412965002185 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 412965002186 GTP binding site; other site 412965002187 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 412965002188 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 412965002189 dimer interface [polypeptide binding]; other site 412965002190 putative functional site; other site 412965002191 putative MPT binding site; other site 412965002192 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 412965002193 trimer interface [polypeptide binding]; other site 412965002194 dimer interface [polypeptide binding]; other site 412965002195 putative active site [active] 412965002196 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 412965002197 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965002198 FeS/SAM binding site; other site 412965002199 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 412965002200 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 412965002201 MoaE interaction surface [polypeptide binding]; other site 412965002202 MoeB interaction surface [polypeptide binding]; other site 412965002203 thiocarboxylated glycine; other site 412965002204 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 412965002205 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 412965002206 nitrate reductase, beta subunit; Region: narH; TIGR01660 412965002207 4Fe-4S binding domain; Region: Fer4; cl02805 412965002208 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 412965002209 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 412965002210 [4Fe-4S] binding site [ion binding]; other site 412965002211 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965002212 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965002213 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 412965002214 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 412965002215 molybdopterin cofactor binding site; other site 412965002216 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 412965002217 MPT binding site; other site 412965002218 trimer interface [polypeptide binding]; other site 412965002219 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 412965002220 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 412965002221 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 412965002222 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002223 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 412965002224 ribulose bisphosphate carboxylase; Provisional; Region: PRK13475 412965002225 Ribulose bisphosphate carboxylase large chain, Form II; Region: RuBisCO_large_II; cd08211 412965002226 dimer interface [polypeptide binding]; other site 412965002227 active site 412965002228 catalytic residue [active] 412965002229 metal binding site [ion binding]; metal-binding site 412965002230 Probable gene remnant. Similar to the N-terminal region of Rubisco operon transcriptional regulator TR:Q6SEU6 (292 aa). 412965002231 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 412965002232 heterotetramer interface [polypeptide binding]; other site 412965002233 active site pocket [active] 412965002234 cleavage site 412965002235 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 412965002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 412965002237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 412965002238 dimer interface [polypeptide binding]; other site 412965002239 conserved gate region; other site 412965002240 putative PBP binding loops; other site 412965002241 ABC-ATPase subunit interface; other site 412965002242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 412965002243 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 412965002244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 412965002245 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 412965002246 Walker A/P-loop; other site 412965002247 ATP binding site [chemical binding]; other site 412965002248 Q-loop/lid; other site 412965002249 ABC transporter signature motif; other site 412965002250 Walker B; other site 412965002251 D-loop; other site 412965002252 H-loop/switch region; other site 412965002253 multicopper oxidase; Provisional; Region: PRK10965 412965002254 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 412965002255 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 412965002256 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 412965002257 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 412965002258 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 412965002259 Imelysin; Region: Peptidase_M75; cl09159 412965002260 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 412965002261 Imelysin; Region: Peptidase_M75; cl09159 412965002262 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 412965002263 Cation efflux family; Region: Cation_efflux; cl00316 412965002264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412965002265 catalytic residues [active] 412965002266 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 412965002267 ArsC family; Region: ArsC; pfam03960 412965002268 putative catalytic residues [active] 412965002269 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 412965002270 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 412965002271 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 412965002272 Gram-negative bacterial tonB protein; Region: TonB; cl10048 412965002273 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 412965002274 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 412965002275 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 412965002276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002277 Walker A motif; other site 412965002278 ATP binding site [chemical binding]; other site 412965002279 Walker B motif; other site 412965002280 arginine finger; other site 412965002281 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 412965002282 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 412965002283 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 412965002284 tRNA; other site 412965002285 putative tRNA binding site [nucleotide binding]; other site 412965002286 putative NADP binding site [chemical binding]; other site 412965002287 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 412965002288 peptide chain release factor 1; Validated; Region: prfA; PRK00591 412965002289 RF-1 domain; Region: RF-1; cl02875 412965002290 RF-1 domain; Region: RF-1; cl02875 412965002291 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 412965002292 ABC-ATPase subunit interface; other site 412965002293 dimer interface [polypeptide binding]; other site 412965002294 putative PBP binding regions; other site 412965002295 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 412965002296 metal binding site 2 [ion binding]; metal-binding site 412965002297 putative DNA binding helix; other site 412965002298 metal binding site 1 [ion binding]; metal-binding site 412965002299 dimer interface [polypeptide binding]; other site 412965002300 structural Zn2+ binding site [ion binding]; other site 412965002301 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 412965002302 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 412965002303 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 412965002304 tandem repeat interface [polypeptide binding]; other site 412965002305 oligomer interface [polypeptide binding]; other site 412965002306 active site residues [active] 412965002307 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 412965002308 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002309 Walker A/P-loop; other site 412965002310 ATP binding site [chemical binding]; other site 412965002311 Q-loop/lid; other site 412965002312 ABC transporter signature motif; other site 412965002313 Walker B; other site 412965002314 D-loop; other site 412965002315 H-loop/switch region; other site 412965002316 CcmB protein; Region: CcmB; cl01016 412965002317 S-adenosylmethionine synthetase; Validated; Region: PRK05250 412965002318 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 412965002319 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 412965002320 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 412965002321 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 412965002322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002323 oligomerization interface [polypeptide binding]; other site 412965002324 active site 412965002325 NAD+ binding site [chemical binding]; other site 412965002326 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 412965002327 dimer interface [polypeptide binding]; other site 412965002328 motif 1; other site 412965002329 active site 412965002330 motif 2; other site 412965002331 motif 3; other site 412965002332 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 412965002333 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 412965002334 Peptidase family M23; Region: Peptidase_M23; pfam01551 412965002335 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 412965002336 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 412965002337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 412965002338 FeS/SAM binding site; other site 412965002339 TRAM domain; Region: TRAM; cl01282 412965002340 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 412965002341 Cu(I) binding site [ion binding]; other site 412965002342 Protein of unknown function (DUF461); Region: DUF461; cl01071 412965002343 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 412965002344 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 412965002345 Ligand Binding Site [chemical binding]; other site 412965002346 Protein of unknown function (DUF489); Region: DUF489; cl01097 412965002347 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 412965002348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 412965002349 Smr domain; Region: Smr; cl02619 412965002350 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 412965002351 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 412965002352 generic binding surface II; other site 412965002353 generic binding surface I; other site 412965002354 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 412965002355 substrate binding site; other site 412965002356 dimer interface; other site 412965002357 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 412965002358 homotrimer interaction site [polypeptide binding]; other site 412965002359 zinc binding site [ion binding]; other site 412965002360 CDP-binding sites; other site 412965002361 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 412965002362 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 412965002363 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965002364 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 412965002365 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 412965002366 FAD binding domain; Region: FAD_binding_4; pfam01565 412965002367 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 412965002368 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 412965002369 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 412965002370 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965002371 BolA-like protein; Region: BolA; cl00386 412965002372 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 412965002373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002374 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 412965002375 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965002376 YccA-like proteins; Region: YccA_like; cd10433 412965002377 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 412965002378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002379 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 412965002380 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 412965002381 threonine synthase; Reviewed; Region: PRK06721 412965002382 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 412965002383 homodimer interface [polypeptide binding]; other site 412965002384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002385 catalytic residue [active] 412965002386 cysteine synthase B; Region: cysM; TIGR01138 412965002387 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 412965002388 dimer interface [polypeptide binding]; other site 412965002389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002390 catalytic residue [active] 412965002391 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 412965002392 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 412965002393 putative ion selectivity filter; other site 412965002394 putative pore gating glutamate residue; other site 412965002395 putative H+/Cl- coupling transport residue; other site 412965002396 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 412965002397 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 412965002398 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 412965002399 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 412965002400 P loop; other site 412965002401 GTP binding site [chemical binding]; other site 412965002402 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 412965002403 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 412965002404 domain interfaces; other site 412965002405 active site 412965002406 argininosuccinate lyase; Provisional; Region: PRK00855 412965002407 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 412965002408 active sites [active] 412965002409 tetramer interface [polypeptide binding]; other site 412965002410 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 412965002411 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 412965002412 putative active site [active] 412965002413 substrate binding site [chemical binding]; other site 412965002414 putative cosubstrate binding site; other site 412965002415 catalytic site [active] 412965002416 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 412965002417 substrate binding site [chemical binding]; other site 412965002418 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 412965002419 Clp amino terminal domain; Region: Clp_N; pfam02861 412965002420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002421 Walker A motif; other site 412965002422 ATP binding site [chemical binding]; other site 412965002423 Walker B motif; other site 412965002424 arginine finger; other site 412965002425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002426 Walker A motif; other site 412965002427 ATP binding site [chemical binding]; other site 412965002428 Walker B motif; other site 412965002429 arginine finger; other site 412965002430 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 412965002431 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 412965002432 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 412965002433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965002434 S-adenosylmethionine binding site [chemical binding]; other site 412965002435 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 412965002436 Fumarase C-terminus; Region: Fumerase_C; cl00795 412965002437 rod shape-determining protein MreB; Provisional; Region: PRK13927 412965002438 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 412965002439 ATP binding site [chemical binding]; other site 412965002440 profilin binding site; other site 412965002441 rod shape-determining protein MreC; Provisional; Region: PRK13922 412965002442 rod shape-determining protein MreC; Region: MreC; pfam04085 412965002443 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 412965002444 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 412965002445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 412965002446 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 412965002447 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 412965002448 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 412965002449 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 412965002450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002451 Walker A/P-loop; other site 412965002452 ATP binding site [chemical binding]; other site 412965002453 Q-loop/lid; other site 412965002454 ABC transporter signature motif; other site 412965002455 Walker B; other site 412965002456 D-loop; other site 412965002457 H-loop/switch region; other site 412965002458 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 412965002459 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 412965002460 catalytic motif [active] 412965002461 Zn binding site [ion binding]; other site 412965002462 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 412965002463 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 412965002464 Flavoprotein; Region: Flavoprotein; cl08021 412965002465 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 412965002466 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 412965002467 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 412965002468 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 412965002469 generic binding surface II; other site 412965002470 generic binding surface I; other site 412965002471 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 412965002472 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 412965002473 Cytochrome c; Region: Cytochrom_C; cl11414 412965002474 anthranilate synthase component I; Provisional; Region: PRK13565 412965002475 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 412965002476 chorismate binding enzyme; Region: Chorismate_bind; cl10555 412965002477 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 412965002478 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 412965002479 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 412965002480 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 412965002481 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 412965002482 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412965002483 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 412965002484 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 412965002485 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 412965002486 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 412965002487 DNA binding site [nucleotide binding] 412965002488 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 412965002489 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 412965002490 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 412965002491 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412965002492 RPB11 interaction site [polypeptide binding]; other site 412965002493 RPB12 interaction site [polypeptide binding]; other site 412965002494 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 412965002495 RPB3 interaction site [polypeptide binding]; other site 412965002496 RPB1 interaction site [polypeptide binding]; other site 412965002497 RPB11 interaction site [polypeptide binding]; other site 412965002498 RPB10 interaction site [polypeptide binding]; other site 412965002499 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 412965002500 core dimer interface [polypeptide binding]; other site 412965002501 peripheral dimer interface [polypeptide binding]; other site 412965002502 L10 interface [polypeptide binding]; other site 412965002503 L11 interface [polypeptide binding]; other site 412965002504 putative EF-Tu interaction site [polypeptide binding]; other site 412965002505 putative EF-G interaction site [polypeptide binding]; other site 412965002506 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 412965002507 23S rRNA interface [nucleotide binding]; other site 412965002508 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 412965002509 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 412965002510 mRNA/rRNA interface [nucleotide binding]; other site 412965002511 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 412965002512 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 412965002513 23S rRNA interface [nucleotide binding]; other site 412965002514 L7/L12 interface [polypeptide binding]; other site 412965002515 putative thiostrepton binding site; other site 412965002516 L25 interface [polypeptide binding]; other site 412965002517 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 412965002518 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 412965002519 putative homodimer interface [polypeptide binding]; other site 412965002520 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 412965002521 elongation factor Tu; Reviewed; Region: PRK00049 412965002522 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 412965002523 G1 box; other site 412965002524 GEF interaction site [polypeptide binding]; other site 412965002525 GTP/Mg2+ binding site [chemical binding]; other site 412965002526 Switch I region; other site 412965002527 G2 box; other site 412965002528 G3 box; other site 412965002529 Switch II region; other site 412965002530 G4 box; other site 412965002531 G5 box; other site 412965002532 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 412965002533 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 412965002534 Antibiotic Binding Site [chemical binding]; other site 412965002535 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 412965002536 Malic enzyme, N-terminal domain; Region: malic; pfam00390 412965002537 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 412965002538 putative NAD(P) binding site [chemical binding]; other site 412965002539 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 412965002540 nucleotide binding site/active site [active] 412965002541 HIT family signature motif; other site 412965002542 catalytic residue [active] 412965002543 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 412965002544 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 412965002545 putative FMN binding site [chemical binding]; other site 412965002546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 412965002547 dihydrodipicolinate reductase; Provisional; Region: PRK00048 412965002548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002549 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 412965002550 NeuB family; Region: NeuB; cl00496 412965002551 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 412965002552 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 412965002553 active site 412965002554 ribulose/triose binding site [chemical binding]; other site 412965002555 phosphate binding site [ion binding]; other site 412965002556 substrate (anthranilate) binding pocket [chemical binding]; other site 412965002557 product (indole) binding pocket [chemical binding]; other site 412965002558 OsmC-like protein; Region: OsmC; cl00767 412965002559 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 412965002560 ThiS interaction site; other site 412965002561 putative active site [active] 412965002562 tetramer interface [polypeptide binding]; other site 412965002563 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 412965002564 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 412965002565 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 412965002566 catalytic residue [active] 412965002567 putative pimeloyl-BioC--CoA transferase BioH; Region: bioH; TIGR01738 412965002568 AIR carboxylase; Region: AIRC; cl00310 412965002569 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 412965002570 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965002571 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 412965002572 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 412965002573 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 412965002574 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 412965002575 homodimer interface [polypeptide binding]; other site 412965002576 NADP binding site [chemical binding]; other site 412965002577 substrate binding site [chemical binding]; other site 412965002578 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 412965002579 Ligand binding site; other site 412965002580 oligomer interface; other site 412965002581 Trm112p-like protein; Region: Trm112p; cl01066 412965002582 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 412965002583 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 412965002584 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 412965002585 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 412965002586 FtsX-like permease family; Region: FtsX; cl15850 412965002587 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 412965002588 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 412965002589 Walker A/P-loop; other site 412965002590 ATP binding site [chemical binding]; other site 412965002591 Q-loop/lid; other site 412965002592 ABC transporter signature motif; other site 412965002593 Walker B; other site 412965002594 D-loop; other site 412965002595 H-loop/switch region; other site 412965002596 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 412965002597 tetramerization interface [polypeptide binding]; other site 412965002598 active site 412965002599 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 412965002600 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 412965002601 oxaloacetate decarboxylase; Provisional; Region: PRK14040 412965002602 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 412965002603 active site 412965002604 catalytic residues [active] 412965002605 metal binding site [ion binding]; metal-binding site 412965002606 homodimer binding site [polypeptide binding]; other site 412965002607 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412965002608 carboxyltransferase (CT) interaction site; other site 412965002609 biotinylation site [posttranslational modification]; other site 412965002610 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 412965002611 rRNA binding site [nucleotide binding]; other site 412965002612 predicted 30S ribosome binding site; other site 412965002613 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 412965002614 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 412965002615 FAD binding site [chemical binding]; other site 412965002616 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 412965002617 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 412965002618 active site 412965002619 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 412965002620 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 412965002621 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 412965002622 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965002623 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 412965002624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002625 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 412965002626 catalytic triad [active] 412965002627 Polysulphide reductase, NrfD; Region: NrfD; cl01295 412965002628 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 412965002629 4Fe-4S binding domain; Region: Fer4; cl02805 412965002630 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 412965002631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002632 4Fe-4S binding domain; Region: Fer4; cl02805 412965002633 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 412965002634 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 412965002635 DsrC like protein; Region: DsrC; cl01101 412965002636 DsrE/DsrF-like family; Region: DrsE; cl00672 412965002637 DsrE/DsrF-like family; Region: DrsE; cl00672 412965002638 DsrE/DsrF-like family; Region: DrsE; cl00672 412965002639 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 412965002640 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 412965002641 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 412965002642 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 412965002643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002644 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 412965002645 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 412965002646 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 412965002647 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 412965002648 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 412965002649 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412965002650 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965002651 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 412965002652 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412965002653 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965002654 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 412965002655 IMP binding site; other site 412965002656 dimer interface [polypeptide binding]; other site 412965002657 interdomain contacts; other site 412965002658 partial ornithine binding site; other site 412965002659 VacJ like lipoprotein; Region: VacJ; cl01073 412965002660 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 412965002661 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 412965002662 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 412965002663 catalytic site [active] 412965002664 subunit interface [polypeptide binding]; other site 412965002665 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 412965002666 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 412965002667 thiS-thiF/thiG interaction site; other site 412965002668 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 412965002669 Ligand Binding Site [chemical binding]; other site 412965002670 DsrC like protein; Region: DsrC; cl01101 412965002671 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 412965002672 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 412965002673 motif 1; other site 412965002674 active site 412965002675 motif 2; other site 412965002676 motif 3; other site 412965002677 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 412965002678 DHHA1 domain; Region: DHHA1; pfam02272 412965002679 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 412965002680 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 412965002681 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 412965002682 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 412965002683 glutaminase active site [active] 412965002684 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 412965002685 dimer interface [polypeptide binding]; other site 412965002686 active site 412965002687 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 412965002688 dimer interface [polypeptide binding]; other site 412965002689 active site 412965002690 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 412965002691 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 412965002692 dimer interface [polypeptide binding]; other site 412965002693 active site 412965002694 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 412965002695 dimer interface [polypeptide binding]; other site 412965002696 active site 412965002697 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 412965002698 active site 412965002699 tetramer interface; other site 412965002700 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 412965002701 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 412965002702 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 412965002703 putative ADP-binding pocket [chemical binding]; other site 412965002704 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 412965002705 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 412965002706 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 412965002707 active site 412965002708 HIGH motif; other site 412965002709 nucleotide binding site [chemical binding]; other site 412965002710 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 412965002711 KMSKS motif; other site 412965002712 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 412965002713 Survival protein SurE; Region: SurE; cl00448 412965002714 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 412965002715 Clp amino terminal domain; Region: Clp_N; pfam02861 412965002716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002717 Walker A motif; other site 412965002718 ATP binding site [chemical binding]; other site 412965002719 Walker B motif; other site 412965002720 arginine finger; other site 412965002721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 412965002722 Walker A motif; other site 412965002723 ATP binding site [chemical binding]; other site 412965002724 Walker B motif; other site 412965002725 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 412965002726 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 412965002727 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 412965002728 GMP synthase; Reviewed; Region: guaA; PRK00074 412965002729 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 412965002730 AMP/PPi binding site [chemical binding]; other site 412965002731 candidate oxyanion hole; other site 412965002732 catalytic triad [active] 412965002733 potential glutamine specificity residues [chemical binding]; other site 412965002734 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 412965002735 ATP Binding subdomain [chemical binding]; other site 412965002736 Ligand Binding sites [chemical binding]; other site 412965002737 Dimerization subdomain; other site 412965002738 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 412965002739 nucleoside/Zn binding site; other site 412965002740 dimer interface [polypeptide binding]; other site 412965002741 catalytic motif [active] 412965002742 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 412965002743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002744 NAD(P) binding site [chemical binding]; other site 412965002745 active site 412965002746 Acyl transferase domain; Region: Acyl_transf_1; cl08282 412965002747 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 412965002748 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 412965002749 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 412965002750 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 412965002751 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 412965002752 active site 412965002753 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 412965002754 putative active site [active] 412965002755 putative metal binding site [ion binding]; other site 412965002756 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 412965002757 RNB domain; Region: RNB; pfam00773 412965002758 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 412965002759 lipoyl attachment site [posttranslational modification]; other site 412965002760 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 412965002761 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 412965002762 Intracellular septation protein A; Region: IspA; cl01098 412965002763 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 412965002764 homotrimer interaction site [polypeptide binding]; other site 412965002765 putative active site [active] 412965002766 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 412965002767 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 412965002768 ssDNA binding site; other site 412965002769 generic binding surface II; other site 412965002770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412965002771 ATP binding site [chemical binding]; other site 412965002772 putative Mg++ binding site [ion binding]; other site 412965002773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965002774 nucleotide binding region [chemical binding]; other site 412965002775 ATP-binding site [chemical binding]; other site 412965002776 UTRA domain; Region: UTRA; cl01230 412965002777 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 412965002778 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 412965002779 glutamine binding [chemical binding]; other site 412965002780 catalytic triad [active] 412965002781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412965002782 active site residue [active] 412965002783 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 412965002784 GSH binding site [chemical binding]; other site 412965002785 catalytic residues [active] 412965002786 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 412965002787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002788 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 412965002789 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 412965002790 catalytic core [active] 412965002791 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 412965002792 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 412965002793 23S rRNA interface [nucleotide binding]; other site 412965002794 L3 interface [polypeptide binding]; other site 412965002795 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 412965002796 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412965002797 ATP binding site [chemical binding]; other site 412965002798 Mg++ binding site [ion binding]; other site 412965002799 motif III; other site 412965002800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965002801 nucleotide binding region [chemical binding]; other site 412965002802 ATP-binding site [chemical binding]; other site 412965002803 DbpA RNA binding domain; Region: DbpA; pfam03880 412965002804 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 412965002805 DNA-binding site [nucleotide binding]; DNA binding site 412965002806 RNA-binding motif; other site 412965002807 exonuclease I; Provisional; Region: sbcB; PRK11779 412965002808 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 412965002809 active site 412965002810 substrate binding site [chemical binding]; other site 412965002811 catalytic site [active] 412965002812 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 412965002813 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 412965002814 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 412965002815 minor groove reading motif; other site 412965002816 helix-hairpin-helix signature motif; other site 412965002817 substrate binding pocket [chemical binding]; other site 412965002818 active site 412965002819 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 412965002820 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 412965002821 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 412965002822 putative active site [active] 412965002823 oxyanion strand; other site 412965002824 catalytic triad [active] 412965002825 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 412965002826 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 412965002827 putative active site pocket [active] 412965002828 4-fold oligomerization interface [polypeptide binding]; other site 412965002829 metal binding residues [ion binding]; metal-binding site 412965002830 3-fold/trimer interface [polypeptide binding]; other site 412965002831 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 412965002832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002833 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 412965002834 Uncharacterized conserved protein [Function unknown]; Region: COG0327 412965002835 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 412965002836 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 412965002837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 412965002838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002839 homodimer interface [polypeptide binding]; other site 412965002840 catalytic residue [active] 412965002841 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 412965002842 dimer interface [polypeptide binding]; other site 412965002843 substrate binding site [chemical binding]; other site 412965002844 ATP binding site [chemical binding]; other site 412965002845 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 412965002846 catalytic residues [active] 412965002847 hinge region; other site 412965002848 alpha helical domain; other site 412965002849 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 412965002850 catalytic center binding site [active] 412965002851 ATP binding site [chemical binding]; other site 412965002852 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 412965002853 homooctamer interface [polypeptide binding]; other site 412965002854 active site 412965002855 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 412965002856 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 412965002857 ABC-2 type transporter; Region: ABC2_membrane; cl11417 412965002858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 412965002859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965002860 Walker A/P-loop; other site 412965002861 ATP binding site [chemical binding]; other site 412965002862 Q-loop/lid; other site 412965002863 ABC transporter signature motif; other site 412965002864 Walker B; other site 412965002865 D-loop; other site 412965002866 H-loop/switch region; other site 412965002867 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 412965002868 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412965002869 E3 interaction surface; other site 412965002870 lipoyl attachment site [posttranslational modification]; other site 412965002871 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 412965002872 E3 interaction surface; other site 412965002873 lipoyl attachment site [posttranslational modification]; other site 412965002874 e3 binding domain; Region: E3_binding; pfam02817 412965002875 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 412965002876 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 412965002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 412965002879 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 412965002880 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 412965002881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965002882 S-adenosylmethionine binding site [chemical binding]; other site 412965002883 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 412965002884 Protein export membrane protein; Region: SecD_SecF; cl14618 412965002885 L-aspartate oxidase; Provisional; Region: PRK09077 412965002886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002887 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 412965002888 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 412965002889 active site 412965002890 catalytic residues [active] 412965002891 metal binding site [ion binding]; metal-binding site 412965002892 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 412965002893 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 412965002894 purine monophosphate binding site [chemical binding]; other site 412965002895 dimer interface [polypeptide binding]; other site 412965002896 putative catalytic residues [active] 412965002897 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 412965002898 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 412965002899 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 412965002900 ATP binding site [chemical binding]; other site 412965002901 Mg++ binding site [ion binding]; other site 412965002902 motif III; other site 412965002903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965002904 nucleotide binding region [chemical binding]; other site 412965002905 ATP-binding site [chemical binding]; other site 412965002906 DbpA RNA binding domain; Region: DbpA; pfam03880 412965002907 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 412965002908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965002909 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 412965002910 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 412965002911 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 412965002912 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 412965002913 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 412965002914 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 412965002915 Transporter associated domain; Region: CorC_HlyC; cl08393 412965002916 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 412965002917 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 412965002918 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 412965002919 catalytic residues [active] 412965002920 UGMP family protein; Validated; Region: PRK09604 412965002921 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 412965002922 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 412965002923 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 412965002924 Walker A/P-loop; other site 412965002925 ATP binding site [chemical binding]; other site 412965002926 Q-loop/lid; other site 412965002927 ABC transporter signature motif; other site 412965002928 Walker B; other site 412965002929 D-loop; other site 412965002930 H-loop/switch region; other site 412965002931 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 412965002932 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 412965002933 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 412965002934 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 412965002935 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 412965002936 dimerization interface 3.5A [polypeptide binding]; other site 412965002937 active site 412965002938 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 412965002939 transmembrane helices; other site 412965002940 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 412965002941 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 412965002942 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 412965002943 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 412965002944 active site clefts [active] 412965002945 zinc binding site [ion binding]; other site 412965002946 dimer interface [polypeptide binding]; other site 412965002947 RimM N-terminal domain; Region: RimM; pfam01782 412965002948 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 412965002949 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 412965002950 adenylosuccinate lyase; Provisional; Region: PRK09285 412965002951 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 412965002952 tetramer interface [polypeptide binding]; other site 412965002953 active site 412965002954 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 412965002955 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 412965002956 substrate binding site [chemical binding]; other site 412965002957 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 412965002958 substrate binding site [chemical binding]; other site 412965002959 ligand binding site [chemical binding]; other site 412965002960 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 412965002961 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 412965002962 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 412965002963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412965002964 active site 412965002965 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 412965002966 putative active site [active] 412965002967 putative DNA binding site [nucleotide binding]; other site 412965002968 putative phosphate binding site [ion binding]; other site 412965002969 putative catalytic site [active] 412965002970 metal binding site A [ion binding]; metal-binding site 412965002971 putative AP binding site [nucleotide binding]; other site 412965002972 putative metal binding site B [ion binding]; other site 412965002973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 412965002974 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 412965002975 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 412965002976 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 412965002977 amidophosphoribosyltransferase; Provisional; Region: PRK09246 412965002978 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 412965002979 active site 412965002980 tetramer interface [polypeptide binding]; other site 412965002981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 412965002982 active site 412965002983 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 412965002984 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 412965002985 homodimer interface [polypeptide binding]; other site 412965002986 substrate-cofactor binding pocket; other site 412965002987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965002988 catalytic residue [active] 412965002989 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 412965002990 active site 1 [active] 412965002991 dimer interface [polypeptide binding]; other site 412965002992 active site 2 [active] 412965002993 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 412965002994 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 412965002995 dimer interface [polypeptide binding]; other site 412965002996 active site 412965002997 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 412965002998 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412965002999 Protein export membrane protein; Region: SecD_SecF; cl14618 412965003000 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 412965003001 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 412965003002 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 412965003003 Protein export membrane protein; Region: SecD_SecF; cl14618 412965003004 Preprotein translocase subunit; Region: YajC; cl00806 412965003005 seryl-tRNA synthetase; Provisional; Region: PRK05431 412965003006 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 412965003007 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 412965003008 dimer interface [polypeptide binding]; other site 412965003009 active site 412965003010 motif 1; other site 412965003011 motif 2; other site 412965003012 motif 3; other site 412965003013 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412965003014 active site residue [active] 412965003015 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 412965003016 catalytic residues [active] 412965003017 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 412965003018 active site residue [active] 412965003019 transcriptional regulator NarL; Provisional; Region: PRK10651 412965003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 412965003021 active site 412965003022 phosphorylation site [posttranslational modification] 412965003023 intermolecular recognition site; other site 412965003024 dimerization interface [polypeptide binding]; other site 412965003025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 412965003026 DNA binding residues [nucleotide binding] 412965003027 dimerization interface [polypeptide binding]; other site 412965003028 GAF domain; Region: GAF_2; pfam13185 412965003029 GAF domain; Region: GAF; cl15785 412965003030 Histidine kinase; Region: HisKA_3; pfam07730 412965003031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 412965003032 ATP binding site [chemical binding]; other site 412965003033 Mg2+ binding site [ion binding]; other site 412965003034 G-X-G motif; other site 412965003035 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 412965003036 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 412965003037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 412965003038 GTP/Mg2+ binding site [chemical binding]; other site 412965003039 G4 box; other site 412965003040 G5 box; other site 412965003041 trmE is a tRNA modification GTPase; Region: trmE; cd04164 412965003042 G1 box; other site 412965003043 G1 box; other site 412965003044 GTP/Mg2+ binding site [chemical binding]; other site 412965003045 Switch I region; other site 412965003046 Switch I region; other site 412965003047 G2 box; other site 412965003048 G2 box; other site 412965003049 Switch II region; other site 412965003050 G3 box; other site 412965003051 G3 box; other site 412965003052 Switch II region; other site 412965003053 G4 box; other site 412965003054 G5 box; other site 412965003055 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 412965003056 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 412965003057 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 412965003058 thiamine phosphate binding site [chemical binding]; other site 412965003059 active site 412965003060 pyrophosphate binding site [ion binding]; other site 412965003061 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 412965003062 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 412965003063 active site 412965003064 dimer interface [polypeptide binding]; other site 412965003065 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 412965003066 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 412965003067 active site 412965003068 FMN binding site [chemical binding]; other site 412965003069 substrate binding site [chemical binding]; other site 412965003070 3Fe-4S cluster binding site [ion binding]; other site 412965003071 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 412965003072 domain interface; other site 412965003073 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 412965003074 folate binding site [chemical binding]; other site 412965003075 NADP+ binding site [chemical binding]; other site 412965003076 Maf-like protein; Region: Maf; pfam02545 412965003077 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 412965003078 active site 412965003079 dimer interface [polypeptide binding]; other site 412965003080 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 412965003081 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 412965003082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 412965003083 ATP binding site [chemical binding]; other site 412965003084 putative Mg++ binding site [ion binding]; other site 412965003085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 412965003086 nucleotide binding region [chemical binding]; other site 412965003087 ATP-binding site [chemical binding]; other site 412965003088 TRCF domain; Region: TRCF; cl04088 412965003089 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 412965003090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 412965003091 substrate binding site [chemical binding]; other site 412965003092 ATP binding site [chemical binding]; other site 412965003093 LytB protein; Region: LYTB; cl00507 412965003094 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 412965003095 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 412965003096 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 412965003097 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 412965003098 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 412965003099 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 412965003100 substrate binding site [chemical binding]; other site 412965003101 active site 412965003102 catalytic residues [active] 412965003103 heterodimer interface [polypeptide binding]; other site 412965003104 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 412965003105 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 412965003106 substrate binding site [chemical binding]; other site 412965003107 active site 412965003108 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 412965003109 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 412965003110 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 412965003111 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 412965003112 metal-binding site [ion binding] 412965003113 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 412965003114 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 412965003115 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 412965003116 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 412965003117 Substrate binding site; other site 412965003118 Mg++ binding site; other site 412965003119 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 412965003120 active site 412965003121 substrate binding site [chemical binding]; other site 412965003122 CoA binding site [chemical binding]; other site 412965003123 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 412965003124 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 412965003125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 412965003126 catalytic residue [active] 412965003127 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 412965003128 active site 412965003129 DNA topoisomerase I; Provisional; Region: PRK08780 412965003130 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 412965003131 active site 412965003132 interdomain interaction site; other site 412965003133 putative metal-binding site [ion binding]; other site 412965003134 nucleotide binding site [chemical binding]; other site 412965003135 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 412965003136 domain I; other site 412965003137 DNA binding groove [nucleotide binding] 412965003138 phosphate binding site [ion binding]; other site 412965003139 domain II; other site 412965003140 domain III; other site 412965003141 nucleotide binding site [chemical binding]; other site 412965003142 catalytic site [active] 412965003143 domain IV; other site 412965003144 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 412965003145 Protein of unknown function (DUF494); Region: DUF494; cl01103 412965003146 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 412965003147 Ribonuclease P; Region: Ribonuclease_P; cl00457 412965003148 Haemolytic domain; Region: Haemolytic; cl00506 412965003149 membrane protein insertase; Provisional; Region: PRK01318 412965003150 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 412965003151 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 412965003152 active site 412965003153 iron coordination sites [ion binding]; other site 412965003154 substrate binding pocket [chemical binding]; other site 412965003155 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 412965003156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 412965003157 active site 412965003158 motif I; other site 412965003159 motif II; other site 412965003160 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 412965003161 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 412965003162 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 412965003163 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 412965003164 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 412965003165 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 412965003166 alpha subunit interaction interface [polypeptide binding]; other site 412965003167 Walker A motif; other site 412965003168 ATP binding site [chemical binding]; other site 412965003169 Walker B motif; other site 412965003170 inhibitor binding site; inhibition site 412965003171 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412965003172 ATP synthase; Region: ATP-synt; cl00365 412965003173 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 412965003174 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 412965003175 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 412965003176 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 412965003177 beta subunit interaction interface [polypeptide binding]; other site 412965003178 Walker A motif; other site 412965003179 ATP binding site [chemical binding]; other site 412965003180 Walker B motif; other site 412965003181 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 412965003182 Plant ATP synthase F0; Region: YMF19; cl07975 412965003183 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 412965003184 Plant ATP synthase F0; Region: YMF19; cl07975 412965003185 ATP synthase subunit C; Region: ATP-synt_C; cl00466 412965003186 ATP synthase A chain; Region: ATP-synt_A; cl00413 412965003187 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 412965003188 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 412965003189 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 412965003190 dimer interface [polypeptide binding]; other site 412965003191 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 412965003192 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 412965003193 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 412965003194 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 412965003195 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 412965003196 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 412965003197 DsbD alpha interface [polypeptide binding]; other site 412965003198 catalytic residues [active] 412965003199 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 412965003200 active site 412965003201 trimer interface [polypeptide binding]; other site 412965003202 dimer interface [polypeptide binding]; other site 412965003203 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 412965003204 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 412965003205 carboxyltransferase (CT) interaction site; other site 412965003206 biotinylation site [posttranslational modification]; other site 412965003207 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 412965003208 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 412965003209 ATP-grasp domain; Region: ATP-grasp_4; cl03087 412965003210 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 412965003211 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 412965003212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965003213 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 412965003214 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 412965003215 citrate synthase; Provisional; Region: PRK14036 412965003216 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 412965003217 dimer interface [polypeptide binding]; other site 412965003218 active site 412965003219 citrylCoA binding site [chemical binding]; other site 412965003220 oxalacetate/citrate binding site [chemical binding]; other site 412965003221 coenzyme A binding site [chemical binding]; other site 412965003222 catalytic triad [active] 412965003223 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 412965003224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 412965003225 S-adenosylmethionine binding site [chemical binding]; other site 412965003226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 412965003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 412965003228 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 412965003229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 412965003230 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 412965003231 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 412965003232 5S rRNA interface [nucleotide binding]; other site 412965003233 CTC domain interface [polypeptide binding]; other site 412965003234 L16 interface [polypeptide binding]; other site 412965003235 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 412965003236 putative active site [active] 412965003237 catalytic residue [active] 412965003238 GTP-binding protein YchF; Reviewed; Region: PRK09601 412965003239 YchF GTPase; Region: YchF; cd01900 412965003240 G1 box; other site 412965003241 GTP/Mg2+ binding site [chemical binding]; other site 412965003242 Switch I region; other site 412965003243 G2 box; other site 412965003244 Switch II region; other site 412965003245 G3 box; other site 412965003246 G4 box; other site 412965003247 G5 box; other site 412965003248 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 412965003249 Sulfatase; Region: Sulfatase; cl10460 412965003250 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 412965003251 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 412965003252 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 412965003253 substrate binding site [chemical binding]; other site 412965003254 hexamer interface [polypeptide binding]; other site 412965003255 metal binding site [ion binding]; metal-binding site 412965003256 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 412965003257 rRNA interaction site [nucleotide binding]; other site 412965003258 S8 interaction site; other site 412965003259 putative laminin-1 binding site; other site 412965003260 elongation factor Ts; Provisional; Region: tsf; PRK09377 412965003261 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 412965003262 Elongation factor TS; Region: EF_TS; pfam00889 412965003263 Elongation factor TS; Region: EF_TS; pfam00889 412965003264 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 412965003265 substrate binding site [chemical binding]; other site 412965003266 dimer interface [polypeptide binding]; other site 412965003267 catalytic triad [active] 412965003268 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078