-- dump date 20120504_141544 -- class Genbank::CDS -- table cds_note -- id note NP_444554.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate NP_444555.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_444556.1 conserved hypothetical protein; identified by Glimmer2 NP_444557.1 contains N-terminal domain of unknown function fused to transcription elongation factor; GreA is necessary for efficient RNA polymerization through arresting sites; cleaves the nascent transcript and allows resumption of transcription elongation NP_444558.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate NP_444559.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_444560.1 similar to GB:L42023 SP:P45157 PID:1007310 PID:1221453 PID:1574781; identified by sequence similarity NP_444561.1 similar to ; identified by sequence similarity NP_444562.1 conserved hypothetical protein; identified by Glimmer2 NP_444563.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_444564.1 conserved hypothetical protein; identified by Glimmer2 NP_444565.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_444566.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues NP_444567.1 hypothetical protein; identified by Glimmer2 NP_444568.1 conserved hypothetical protein; identified by Glimmer2 NP_444569.1 conserved hypothetical protein; identified by Glimmer2 NP_444570.1 conserved hypothetical protein; identified by Glimmer2 NP_444571.1 conserved hypothetical protein; identified by Glimmer2 NP_444572.1 conserved hypothetical protein; identified by Glimmer2 NP_444573.1 conserved hypothetical protein; identified by Glimmer2 NP_444574.1 hypothetical protein; identified by Glimmer2 NP_444575.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_444576.1 conserved hypothetical protein; identified by Glimmer2 NP_444577.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis NP_444578.1 conserved hypothetical protein; identified by Glimmer2 NP_444579.1 similar to SP:P33643 PID:1236631 GB:U00096 PID:1788946; identified by sequence similarity NP_444580.1 conserved hypothetical protein; identified by Glimmer2 NP_444581.1 conserved hypothetical protein; identified by Glimmer2 NP_444582.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_444583.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_444584.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins NP_444585.1 conserved hypothetical protein; identified by Glimmer2 NP_444586.1 conserved hypothetical protein; identified by Glimmer2 NP_444587.1 conserved hypothetical protein; identified by Glimmer2 NP_444588.1 conserved hypothetical protein; identified by Glimmer2 NP_444589.1 conserved hypothetical protein; identified by Glimmer2 NP_444590.1 conserved hypothetical protein; identified by Glimmer2 NP_444591.1 similar to SP:P21211 GB:U02499 SP:P21212 SP:P40290 PID:437202; identified by sequence similarity NP_444592.1 conserved hypothetical protein; identified by Glimmer2 NP_444593.1 conserved hypothetical protein; identified by Glimmer2 NP_444594.1 type III secretion translocase SctQ; identified by match to PFAM protein family HMM PF01052 NP_444595.1 serine/threonine-protein kinase; identified by match to PFAM protein family HMM PF00069 NP_444596.1 similar to GP:3978475; identified by sequence similarity NP_444597.1 similar to GB:D26185 SP:P37570 GB:U02604 PID:442359 PID:467473; identified by sequence similarity NP_444598.1 conserved hypothetical protein; identified by Glimmer2 NP_444599.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_444600.1 Catalyzes the phosphorylation of UMP to UDP NP_444601.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_444602.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_444603.1 similar to GB:AE001363; identified by sequence similarity NP_444604.1 penicillin-binding protein, ; identified by match to PFAM protein family HMM PF00905 NP_444605.1 type III secretion chaperone, ; identified by match to PFAM protein family HMM PF00515 NP_444606.1 with SufCD activates cysteine desulfurase SufS NP_444607.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_444608.1 conserved hypothetical protein; identified by Glimmer2 NP_444609.1 aminotransferase, class V; identified by match to PFAM protein family HMM PF00266 NP_444610.1 conserved hypothetical protein; identified by Glimmer2 NP_444611.1 conserved hypothetical protein; identified by Glimmer2 NP_444612.1 hypothetical protein; identified by Glimmer2 NP_444613.1 hypothetical protein; identified by Glimmer2 NP_444614.1 similar to GB:D26185 SP:P26497 GB:M59938 PID:143640 PID:40031; identified by sequence similarity NP_444615.1 hypothetical protein; identified by Glimmer2 NP_444616.1 similar to SP:P42065 PID:677944 GB:AL009126; identified by sequence similarity NP_444617.1 similar to GB:M57689 SP:P24136 GB:X56347 PID:143607 PID:580898; identified by sequence similarity NP_444618.1 conserved hypothetical protein; identified by Glimmer2 NP_444619.1 phosphate permease family protein; identified by match to PFAM protein family HMM PF01384 NP_444620.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_444621.1 hypothetical protein; identified by Glimmer2 NP_444622.1 hypothetical protein; identified by Glimmer2 NP_444623.1 conserved hypothetical protein; identified by Glimmer2 NP_444624.1 conserved hypothetical protein; identified by Glimmer2 NP_444625.1 Nol1/Nop2/Sun family protein; identified by match to PFAM protein family HMM PF01189 NP_444626.1 conserved hypothetical protein; identified by Glimmer2 NP_444627.1 similar to GB:L09228 SP:P35150 GB:M84227 PID:410134 GB:AL009126; identified by sequence similarity NP_444628.1 conserved hypothetical protein; identified by Glimmer2 NP_444629.1 similar to GB:M34995 SP:P17904 PID:143459 PID:1881282 PID:1881282; identified by sequence similarity NP_444630.1 conserved hypothetical protein; identified by Glimmer2 NP_444631.1 conserved hypothetical protein; identified by Glimmer2 NP_444632.1 conserved hypothetical protein; identified by Glimmer2 NP_444633.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase NP_444634.1 similar to GB:M89480 SP:P27669 GB:X52093 PID:154410; identified by sequence similarity NP_444635.1 hypothetical protein; identified by Glimmer2 NP_444636.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_444637.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_444638.1 similar to SP:P26623 GB:X66126 GB:X66127 GB:X66128 PID:40700; identified by sequence similarity NP_444639.1 spoU rRNA methylase family protein; identified by match to TIGR protein family HMM TIGR00185 NP_444640.1 similar to GB:J03294 SP:P14949 GB:X79976 PID:142520 PID:1770044; identified by sequence similarity NP_444641.1 conserved hypothetical protein; identified by Glimmer2 NP_444642.1 conserved hypothetical protein; identified by Glimmer2 NP_444643.1 hypothetical protein; identified by Glimmer2 NP_444644.1 3'-5' exonuclease of DNA polymerase III NP_444645.1 similar to SP:Q64559 PID:1915948 PID:1944428 PID:2130523 PID:1752786; identified by sequence similarity NP_444646.1 Transfers the fatty acyl group on membrane lipoproteins NP_444647.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis NP_444648.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_444649.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis NP_444650.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_444651.1 conserved hypothetical protein; identified by Glimmer2 NP_444652.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_444653.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_444654.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_444655.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_444656.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_444657.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_444658.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_444659.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_444660.1 one of the stabilizing components for the large ribosomal subunit NP_444661.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_444662.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_444663.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_444664.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_444665.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_444666.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_444667.1 binds 5S rRNA along with protein L5 and L25 NP_444668.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_444669.1 late assembly protein NP_444670.2 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_444671.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_444672.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_444673.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_444674.1 is a component of the macrolide binding site in the peptidyl transferase center NP_444675.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate NP_444676.1 conserved hypothetical protein; identified by Glimmer2 NP_444677.1 conserved hypothetical protein; identified by Glimmer2 NP_444678.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity NP_444679.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_444680.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_444681.1 similar to GB:U14003 SP:P32099 GB:X03046 PID:432634 PID:504496; identified by sequence similarity NP_444682.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_444683.1 unwinds double stranded DNA NP_444684.1 similar to GB:M12299 SP:P06978 PID:473749 GB:U00096 PID:1736571; identified by sequence similarity NP_444685.1 similar to GB:M28816 SP:P19568 PID:152470 GB:AJ235269; identified by sequence similarity NP_444686.1 similar to GP:147868; identified by sequence similarity NP_444687.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair NP_444688.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_444689.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes NP_444690.1 conserved hypothetical protein; identified by Glimmer2 NP_444691.1 catalyzes the formation of orotidine monophosphate from 5-phosphoribosyl-1-pyrophosphate and orotate NP_444692.1 similar to SP:P30521 PID:580714; identified by sequence similarity NP_444693.1 conserved hypothetical protein; identified by Glimmer2 NP_444694.1 conserved hypothetical protein; identified by Glimmer2 NP_444695.1 similar to SP:P10344 PID:41569 GB:U00096 PID:1651365 PID:1651371; identified by sequence similarity NP_444696.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic NP_444697.1 conserved hypothetical protein; identified by Glimmer2 NP_444698.1 conserved hypothetical protein; identified by Glimmer2 NP_444699.1 hypothetical protein; identified by Glimmer2 NP_444700.1 hypothetical protein; identified by Glimmer2 NP_444701.1 similar to SP:P42061 PID:677945 GB:AL009126; identified by sequence similarity NP_444702.1 similar to SP:P26903 PID:580850 GB:AL009126; identified by sequence similarity NP_444703.1 similar to SP:P08006 GB:X05491 GB:X52093 PID:47804; identified by sequence similarity NP_444704.1 DNA methyltransferase; identified by match to PFAM protein family HMM PF01035 NP_444705.1 conserved hypothetical protein; identified by Glimmer2 NP_444706.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_444707.1 conserved hypothetical protein; identified by Glimmer2 NP_444708.1 conserved hypothetical protein; identified by Glimmer2 NP_444709.1 conserved hypothetical protein; identified by Glimmer2 NP_444710.1 conserved hypothetical protein; identified by Glimmer2 NP_444711.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA NP_444712.1 conserved hypothetical protein; identified by Glimmer2 NP_444713.1 conserved hypothetical protein; identified by Glimmer2 NP_444714.1 sigma-54 dependent response regulator; identified by match to PFAM protein family HMM PF00158 NP_444715.1 hypothetical protein; identified by Glimmer2 NP_444716.1 sensor histidine kinase; identified by match to PFAM protein family HMM PF00989 NP_444717.1 conserved hypothetical protein; identified by Glimmer2 NP_444718.1 conserved hypothetical protein; identified by Glimmer2 NP_444719.1 hydrolase, haloacid dehalogenase-like family; identified by match to PFAM protein family HMM PF00702 NP_444720.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_444721.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_444722.1 conserved hypothetical protein; identified by Glimmer2 NP_444723.1 conserved hypothetical protein; identified by Glimmer2 NP_444724.1 hypothetical protein; identified by Glimmer2 NP_444725.1 acetyltransferase, GNAT family; identified by match to PFAM protein family HMM PF00583 NP_444726.1 hypothetical protein; identified by Glimmer2 NP_444727.1 conserved hypothetical protein; identified by Glimmer2 NP_444728.1 hypothetical protein; identified by Glimmer2 NP_444729.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_444730.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_444731.1 1-acyl-sn-glycerol-3-phosphate acyltransferase, ; identified by match to PFAM protein family HMM PF01553 NP_444732.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_444733.1 similar to GB:M11330 SP:P06466 PID:1208947 PID:145476 GB:U00096; identified by sequence similarity NP_444734.1 catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate NP_444735.1 hypothetical protein; identified by Glimmer2 NP_444736.1 hypothetical protein; identified by Glimmer2 NP_444737.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; in these organisms there is an unknown N-terminal domain NP_444738.1 similar to GB:M54884 SP:P21893 PID:147550 PID:887842 GB:U00096; identified by sequence similarity NP_444739.1 conserved hypothetical protein; identified by Glimmer2 NP_444740.1 conserved hypothetical protein; identified by Glimmer2 NP_444741.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_444742.1 conserved hypothetical protein; identified by Glimmer2 NP_444743.1 hypothetical protein; identified by Glimmer2 NP_444744.1 similar to PID:1783381; identified by sequence similarity; small CRP; small cysteine-rich protein NP_444745.1 hypothetical protein; identified by Glimmer2 NP_444746.1 similar to SP:P23700 PID:550566 PID:1326243 PID:1326245 GB:AE001363; identified by sequence similarity NP_444747.1 similar to SP:P18587; identified by sequence similarity NP_444748.1 similar to GP:216618; identified by sequence similarity NP_444749.1 conserved hypothetical protein; identified by Glimmer2 NP_444750.1 hypothetical protein; identified by Glimmer2 NP_444751.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_444752.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_444753.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_444754.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_444755.1 oxidoreductase; identified by match to PFAM protein family HMM PF00667 NP_444756.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate NP_444757.1 similar to GB:D13267 SP:P02422 PID:216636 PID:606124 GB:U00096; identified by sequence similarity NP_444758.1 involved in the peptidyltransferase reaction during translation NP_444759.2 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_444760.1 similar to PID:1245464 SP:Q56955 PID:1245467; identified by sequence similarity NP_444761.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_444762.1 similar to GP:3758895; identified by sequence similarity NP_444763.1 similar to GP:4376830; identified by sequence similarity NP_444764.1 similar to GP:4376829; identified by sequence similarity NP_444765.1 conserved hypothetical protein; identified by Glimmer2 NP_444766.1 conserved hypothetical protein; identified by Glimmer2 NP_444767.1 sodium/alanine symporter family protein; identified by match to PFAM protein family HMM PF01235 NP_444768.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_444769.1 conserved hypothetical protein; identified by Glimmer2 NP_444770.1 conserved hypothetical protein; identified by Glimmer2 NP_444771.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_444772.1 conserved hypothetical protein; identified by Glimmer2 NP_444773.1 spoU rRNA methylase family protein; identified by match to PFAM protein family HMM PF00588 NP_444774.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate NP_444775.1 sodium:dicarboxylate symporter family protein; identified by match to PFAM protein family HMM PF00375 NP_444776.1 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA NP_444777.1 similar to SP:P17115 GB:X51361 PID:41632 PID:882600 GB:U00096; identified by sequence similarity NP_444778.1 hypothetical protein; identified by Glimmer2 NP_444779.1 conserved hypothetical protein; identified by Glimmer2 NP_444780.1 hypothetical protein; identified by Glimmer2 NP_444781.1 hypothetical protein; identified by Glimmer2 NP_444782.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis NP_444783.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_444784.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_444785.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate NP_444786.1 conserved hypothetical protein; identified by Glimmer2 NP_444787.1 hypothetical protein; identified by Glimmer2 NP_444788.1 hypothetical protein; identified by Glimmer2 NP_444789.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone NP_444790.1 conserved hypothetical protein; identified by Glimmer2 NP_444791.1 conserved hypothetical protein; identified by Glimmer2 NP_444792.1 hypothetical protein; identified by Glimmer2 NP_444793.1 conserved hypothetical protein; identified by Glimmer2 NP_444794.1 anti-anti-sigma factor; identified by match to PFAM protein family HMM PF01740 NP_444795.1 similar to GB:X73141 PID:511148; identified by sequence similarity NP_444796.1 conserved hypothetical protein; identified by Glimmer2 NP_444797.1 conserved hypothetical protein; identified by Glimmer2 NP_444798.1 conserved hypothetical protein; identified by Glimmer2 NP_444799.1 similar to SP:Q39147; identified by sequence similarity NP_444800.1 exoribonuclease, VacB/Rnb family; identified by match to PFAM protein family HMM PF00773 NP_444801.1 hypothetical protein; identified by Glimmer2 NP_444802.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_444803.1 similar to GB:M84964 SP:P15874 GB:X51477 PID:143058 PID:39928; identified by sequence similarity NP_444804.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons NP_444805.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_444806.1 conserved hypothetical protein; identified by Glimmer2 NP_444807.1 hypothetical protein; identified by Glimmer2 NP_444808.1 conserved hypothetical protein; identified by Glimmer2 NP_444809.1 conserved hypothetical protein; identified by Glimmer2 NP_444810.1 catalyzes the interconversion of tetrahydrodipicolinate and L,L-diaminopimelate in lysine biosynthesis NP_444811.1 hypothetical protein; identified by Glimmer2 NP_444812.1 hypothetical protein; identified by Glimmer2 NP_444813.1 hypothetical protein; identified by Glimmer2 NP_444814.1 conserved hypothetical protein; identified by Glimmer2 NP_444815.1 conserved hypothetical protein; identified by Glimmer2 NP_444816.1 conserved hypothetical protein; identified by Glimmer2 NP_444817.1 HIT family protein; identified by match to PFAM protein family HMM PF01230 NP_444818.1 conserved hypothetical protein; identified by Glimmer2 NP_444819.1 sodium:solute symporter family protein; identified by match to PFAM protein family HMM PF00474 NP_444820.1 hypothetical protein; identified by Glimmer2 NP_444821.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate NP_444822.1 hypothetical protein; identified by Glimmer2 NP_444823.1 similar to SP:P30860 GB:X67753 GB:X86160 PID:40934 PID:769794; identified by sequence similarity NP_444824.1 conserved hypothetical protein; identified by Glimmer2 NP_444825.1 metal-dependent hydrolase, ; identified by match to PFAM protein family HMM PF00753 NP_444826.1 similar to GB:AE001273; identified by sequence similarity NP_444827.1 conserved hypothetical protein; identified by Glimmer2 NP_444828.1 conserved hypothetical protein; identified by Glimmer2 NP_444829.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain NP_444830.1 conserved hypothetical protein; identified by Glimmer2 NP_444831.1 hypothetical protein; identified by Glimmer2 NP_444832.1 hypothetical protein; identified by Glimmer2 NP_444833.1 similar to GP:4376753; identified by sequence similarity NP_444834.1 similar to GP:4376752; identified by sequence similarity NP_444835.1 similar to GP:4376751; identified by sequence similarity NP_444836.1 hypothetical protein; identified by Glimmer2 NP_444837.1 hypothetical protein; identified by Glimmer2 NP_444838.1 hypothetical protein; identified by Glimmer2 NP_444839.1 hypothetical protein; identified by Glimmer2 NP_444840.1 hypothetical protein; identified by Glimmer2 NP_444841.1 hypothetical protein; identified by Glimmer2 NP_444842.1 hypothetical protein; identified by Glimmer2 NP_444843.1 hypothetical protein; identified by Glimmer2 NP_444844.1 hypothetical protein; identified by Glimmer2 NP_444845.1 hypothetical protein; identified by Glimmer2 NP_444846.1 hypothetical protein; identified by Glimmer2 NP_444847.1 similar to GP:4376737; identified by sequence similarity NP_444848.1 similar to GP:4376736; identified by sequence similarity NP_444849.1 hypothetical protein; identified by Glimmer2 NP_444850.1 similar to GP:4376735; identified by sequence similarity NP_444851.1 similar to GP:4376733; identified by sequence similarity NP_444852.1 similar to GP:4376729; identified by sequence similarity NP_444853.1 hypothetical protein; identified by Glimmer2 NP_444854.1 conserved hypothetical protein; identified by Glimmer2 NP_444855.1 similar to GP:4376731; identified by sequence similarity NP_444856.1 similar to GP:4376729; identified by sequence similarity NP_444857.1 similar to GP:4376728; identified by sequence similarity NP_444858.1 similar to GP:4376727; identified by sequence similarity NP_444859.1 conserved hypothetical protein; identified by Glimmer2 NP_444860.1 conserved hypothetical protein; identified by Glimmer2 NP_444861.1 conserved hypothetical protein; identified by Glimmer2 NP_444862.1 hypothetical protein; identified by Glimmer2 NP_444863.1 hypothetical protein; identified by Glimmer2 NP_444864.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_444865.1 similar to SP:P31541; identified by sequence similarity NP_444866.1 conserved hypothetical protein; identified by Glimmer2 NP_444867.1 phospholipase D family protein; identified by match to PFAM protein family HMM PF00614 NP_444868.1 conserved hypothetical protein; identified by Glimmer2 NP_444869.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor NP_444870.1 hypothetical protein; identified by Glimmer2 NP_444871.1 hypothetical protein; identified by Glimmer2 NP_444872.1 similar to PID:893416 PID:893415; identified by sequence similarity NP_444873.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm NP_444874.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_444875.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_444876.1 conserved hypothetical protein; identified by Glimmer2 NP_444877.1 conserved hypothetical protein; identified by Glimmer2 NP_444878.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_444879.1 similar to GB:AE001273; identified by sequence similarity NP_444880.1 conserved hypothetical protein; identified by Glimmer2 NP_444881.1 hypothetical protein; identified by Glimmer2 NP_444882.1 conserved hypothetical protein; identified by Glimmer2 NP_444883.1 hypothetical protein; identified by Glimmer2 NP_444884.1 similar to GB:X07469 SP:P08149 GB:M32091 GB:X07468 GB:X07470; identified by sequence similarity NP_444885.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate NP_444886.1 similar to GB:D10388 SP:Q02114 GB:M81324 PID:142806 PID:143159; identified by sequence similarity NP_444887.1 similar to GB:L35259 GB:M64046 PID:535713 SP:Q51473; identified by sequence similarity NP_444888.1 conserved hypothetical protein; identified by Glimmer2 NP_444889.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein NP_444890.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00664 NP_444891.1 conserved hypothetical protein; identified by Glimmer2 NP_444892.1 conserved hypothetical protein; identified by Glimmer2 NP_444893.1 3'-5' exonuclease of DNA polymerase III NP_444894.1 conserved hypothetical protein; identified by Glimmer2 NP_444895.1 conserved hypothetical protein; identified by Glimmer2 NP_444896.1 hypothetical protein; identified by Glimmer2 NP_444897.1 conserved hypothetical protein; identified by Glimmer2 NP_444898.1 Catalyzes a key regulatory step in fatty acid biosynthesis NP_444899.1 hypothetical protein; identified by Glimmer2 NP_444900.1 hypothetical protein; identified by Glimmer2 NP_444901.1 similar to GB:M59471 SP:P17802 GB:X52391 PID:146864 PID:42073; identified by sequence similarity NP_444902.1 similar to GB:J04039 SP:P33646 PID:416198 PID:882675 GB:U00096; identified by sequence similarity NP_444903.1 conserved hypothetical protein; identified by Glimmer2 NP_444904.1 conserved hypothetical protein; identified by Glimmer2 NP_444905.1 hypothetical protein; identified by Glimmer2 NP_444906.1 serine/threonine protein phosphatase, ; identified by match to PFAM protein family HMM PF00481 NP_444907.1 similar to PID:762778 SP:Q43884; identified by sequence similarity NP_444908.1 conserved hypothetical protein; identified by Glimmer2 NP_444909.1 conserved hypothetical protein; identified by Glimmer2 NP_444910.1 conserved hypothetical protein; identified by Glimmer2 NP_444911.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis NP_444912.1 hypothetical protein; identified by Glimmer2 NP_444913.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_444914.1 conserved hypothetical protein; identified by Glimmer2 NP_444915.1 similar to PID:1652733; identified by sequence similarity NP_444916.1 conserved hypothetical protein; identified by Glimmer2 NP_444917.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_444918.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides NP_444919.1 similar to GB:L12963 GB:L10193 PID:144509 PID:289839; identified by sequence similarity NP_444920.1 conserved hypothetical protein; identified by Glimmer2 NP_444921.1 tetrapyrrole methylase family protein; identified by match to PFAM protein family HMM PF00590 NP_444922.1 hypothetical protein; identified by Glimmer2 NP_444923.1 conserved hypothetical protein; identified by Glimmer2 NP_444924.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_444925.1 conserved hypothetical protein; identified by Glimmer2 NP_444926.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide NP_444927.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA NP_444928.1 hypothetical protein; identified by Glimmer2 NP_444929.1 hypothetical protein; identified by Glimmer2 NP_444930.1 conserved hypothetical protein; identified by Glimmer2 NP_444931.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-clclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; these proteins appear to consist of duplicate domains as compared to Escherichia coli IspG NP_444932.1 hypothetical protein; identified by Glimmer2 NP_444933.1 hypothetical protein; identified by Glimmer2 NP_444934.1 hypothetical protein; identified by Glimmer2 NP_444935.1 conserved hypothetical protein; identified by Glimmer2 NP_444936.1 conserved hypothetical protein; identified by Glimmer2 NP_444937.1 hypothetical protein; identified by Glimmer2 NP_444938.1 hypothetical protein; identified by Glimmer2 NP_444939.1 conserved hypothetical protein; identified by Glimmer2 NP_444940.1 hypothetical protein; identified by Glimmer2 NP_444941.1 hypothetical protein; identified by Glimmer2 NP_444942.1 similar to GB:M59855 SP:P16022 GB:X51316 PID:151916 PID:435529; identified by sequence similarity NP_444943.1 protein export protein, FHIPEP family; identified by match to PFAM protein family HMM PF00771 NP_444944.1 expressed in response to temperature increase; may be involved in expression of genes involved in the developmental cycle of Chlamydia NP_444945.1 hypothetical protein; identified by Glimmer2 NP_444946.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_444947.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_444948.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_444949.1 hypothetical protein; identified by Glimmer2 NP_444950.1 hypothetical protein; identified by Glimmer2 NP_444951.1 hypothetical protein; identified by Glimmer2 NP_444952.1 hypothetical protein; identified by Glimmer2 NP_444953.1 hypothetical protein; identified by Glimmer2 NP_444954.1 hypothetical protein; identified by Glimmer2 NP_444955.1 hypothetical protein; identified by Glimmer2 NP_444956.1 hypothetical protein; identified by Glimmer2 NP_444957.1 similar to GB:M28816 SP:P19568 PID:152470 GB:AJ235269; identified by sequence similarity NP_444958.1 conserved hypothetical protein; identified by Glimmer2 NP_444959.1 hypothetical protein; identified by Glimmer2 NP_444960.1 similar to PID:790546 PID:1777933 GB:AE000520; identified by sequence similarity NP_444961.1 similar to PID:1777934 GB:AE000520; identified by sequence similarity NP_444962.1 similar to PID:1777935 GB:AE000520; identified by sequence similarity NP_444963.1 similar to PID:1777936 GB:AE000520; identified by sequence similarity NP_444964.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate NP_444965.1 similar to GB:AE000520; identified by sequence similarity NP_444966.1 conserved hypothetical protein; identified by Glimmer2 NP_444967.1 binds the polymerase to DNA and acts as a sliding clamp NP_444968.1 hypothetical protein; identified by Glimmer2 NP_444969.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_444970.1 similar to SP:P41780; identified by sequence similarity NP_444971.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_444972.1 conserved hypothetical protein; identified by Glimmer2 NP_444973.1 conserved hypothetical protein; identified by Glimmer2 NP_444974.1 conserved hypothetical protein; identified by Glimmer2 NP_444975.1 conserved hypothetical protein; identified by Glimmer2 NP_444976.1 phospholipase D family protein; identified by match to PFAM protein family HMM PF00614 NP_444977.1 conserved hypothetical protein; identified by Glimmer2 NP_444978.1 required for 70S ribosome assembly NP_444979.1 amylomaltase; acts to release glucose from maltodextrins NP_444980.1 similar to GP:2444074; identified by sequence similarity NP_444981.1 similar to PID:2358258; identified by sequence similarity NP_444982.1 similar to GB:M77014 SP:P31487 PID:386718; identified by sequence similarity NP_444983.1 similar to GB:L25667 SP:P40300 PID:475126; identified by sequence similarity NP_444984.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_444985.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities NP_444986.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_444987.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_444988.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_444989.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_444990.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_444991.1 hypothetical protein; identified by Glimmer2 NP_444992.1 similar to SP:P29509; identified by sequence similarity NP_444993.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_444994.1 conserved hypothetical protein; identified by Glimmer2 NP_444995.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_444996.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria NP_444997.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_444998.1 hypothetical protein; identified by Glimmer2 NP_444999.1 similar to SP:P00489; identified by sequence similarity NP_445000.1 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA NP_445001.1 similar to GP:3850999; identified by sequence similarity NP_445002.1 similar to SP:Q06437 PID:2351254; identified by sequence similarity NP_445003.1 conserved hypothetical protein; identified by Glimmer2 NP_445004.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis NP_445005.1 similar to GB:AE001273; identified by sequence similarity NP_445006.1 outer membrane protein, ; identified by match to PFAM protein family HMM PF01103 NP_445007.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_445008.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_445009.1 similar to GB:M87040 SP:P25715 GB:Z11565 PID:145887 PID:41364; identified by sequence similarity NP_445010.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_445011.1 carries the fatty acid chain in fatty acid biosynthesis NP_445012.1 similar to GB:AE001273; identified by sequence similarity NP_445013.1 conserved hypothetical protein; identified by Glimmer2 NP_445014.1 hypothetical protein; identified by Glimmer2 NP_445015.1 similar to PID:2388714; identified by sequence similarity NP_445016.1 sodium-dependent transporter ; identified by match to PFAM protein family HMM PF00209 NP_445017.1 sodium:dicarboxylate symporter family protein; identified by match to PFAM protein family HMM PF00375 NP_445018.1 conserved hypothetical protein; identified by Glimmer2 NP_445019.1 hypothetical protein; identified by Glimmer2 NP_445020.1 magnesium transporter; identified by match to TIGR protein family HMM TIGR00400 NP_445021.1 hypothetical protein; identified by Glimmer2 NP_445022.1 hypothetical protein; identified by Glimmer2 NP_445023.1 similar to GB:U13204 SP:P39183 PID:532328 GB:U00096 PID:1742442; identified by sequence similarity NP_445024.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate NP_445025.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_445026.1 ABC transporter permease; identified by match to PFAM protein family HMM PF00528 NP_445027.1 lipoprotein, ; identified by match to TIGR protein family HMM TIGR00363 NP_445028.1 hypothetical protein; identified by Glimmer2 NP_445029.1 hypothetical protein; identified by Glimmer2 NP_445030.1 conserved hypothetical protein; identified by Glimmer2 NP_445031.1 negatively supercoils closed circular double-stranded DNA NP_445032.1 negatively supercoils closed circular double-stranded DNA NP_445033.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_445034.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA NP_445035.1 similar to GB:S70419 PID:546789; identified by sequence similarity NP_445036.1 similar to SP:P32579 PID:1322770 PID:4566 PID:971384; identified by sequence similarity NP_445037.1 similar to PID:1088400; identified by sequence similarity NP_445038.1 hypothetical protein; identified by Glimmer2 NP_445039.1 hypothetical protein; identified by Glimmer2 NP_445040.1 hypothetical protein; identified by Glimmer2 NP_445041.1 hypothetical protein; identified by Glimmer2 NP_445042.1 hypothetical protein; identified by Glimmer2 NP_445043.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin NP_445044.1 phenylacrylic acid decarboxylase; identified by match to TIGR protein family HMM TIGR00421 NP_445045.1 conserved hypothetical protein; identified by Glimmer2 NP_445046.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate NP_445047.1 conserved hypothetical protein; identified by Glimmer2 NP_445048.1 conserved hypothetical protein; identified by Glimmer2 NP_445049.1 hypothetical protein; identified by Glimmer2 NP_445050.1 conserved hypothetical protein; identified by Glimmer2 NP_445051.1 conserved hypothetical protein; identified by Glimmer2 NP_445052.1 conserved hypothetical protein; identified by Glimmer2 NP_445053.1 conserved hypothetical protein; identified by Glimmer2 NP_445054.1 conserved hypothetical protein; identified by Glimmer2 NP_445055.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_445056.1 conserved hypothetical protein; identified by Glimmer2 NP_445057.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_445058.1 hypothetical protein; identified by Glimmer2 NP_445059.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_445060.1 forms a direct contact with the tRNA during translation NP_445061.1 NLP/P60 family protein; identified by match to PFAM protein family HMM PF00877 NP_445062.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_445063.1 hypothetical protein; identified by Glimmer2 NP_445064.1 hypothetical protein; identified by Glimmer2 NP_445065.1 hypothetical protein; identified by Glimmer2 NP_445066.1 hypothetical protein; identified by Glimmer2 NP_445067.1 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone NP_445068.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_445069.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function NP_445070.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_445071.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS NP_445072.1 hypothetical protein; identified by Glimmer2 NP_445073.1 conserved hypothetical protein; identified by Glimmer2 NP_445074.1 hypothetical protein; identified by Glimmer2 NP_445075.1 hypothetical protein; identified by Glimmer2 NP_445076.1 hypothetical protein; identified by Glimmer2 NP_445077.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_445078.1 conserved hypothetical protein; identified by Glimmer2 NP_445079.1 conserved hypothetical protein; identified by Glimmer2 NP_445080.1 conserved hypothetical protein; identified by Glimmer2 NP_445081.1 lipoprotein, ; identified by match to PROSITE PS00013 NP_445082.1 hypothetical protein; identified by Glimmer2 NP_445083.1 hypothetical protein; identified by Glimmer2 NP_445084.1 hypothetical protein; identified by Glimmer2 NP_445085.1 hypothetical protein; identified by Glimmer2 NP_445086.1 hypothetical protein; identified by Glimmer2 NP_445087.1 conserved hypothetical protein; identified by Glimmer2 NP_445088.1 hypothetical protein; identified by Glimmer2 NP_445089.1 hypothetical protein; identified by Glimmer2 NP_445090.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4, 5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7- deazaguanosine) NP_445091.1 hypothetical protein; identified by Glimmer2 NP_445092.1 conserved hypothetical protein; identified by Glimmer2 NP_445093.1 hypothetical protein; identified by Glimmer2 NP_445094.1 hypothetical protein; identified by Glimmer2 NP_445095.1 hypothetical protein; identified by Glimmer2 NP_445096.1 hypothetical protein; identified by Glimmer2 NP_445097.1 hypothetical protein; identified by Glimmer2 NP_445098.1 hypothetical protein; identified by Glimmer2 NP_445099.1 hypothetical protein; identified by Glimmer2 NP_445100.1 hypothetical protein; identified by Glimmer2 NP_445101.1 hypothetical protein; identified by Glimmer2 NP_445102.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate NP_445103.1 sodium:sulfate symporter family protein; identified by match to PFAM protein family HMM PF00939 NP_445104.1 conserved hypothetical protein; identified by Glimmer2 NP_445105.1 hypothetical protein; identified by Glimmer2 NP_445106.1 hypothetical protein; identified by Glimmer2 NP_445107.1 hypothetical protein; identified by Glimmer2 NP_445108.1 similar to SP:P42065 PID:677944 GB:AL009126; identified by sequence similarity NP_445109.1 similar to GB:M57689 SP:P24136 GB:X56347 PID:143607 PID:580898; identified by sequence similarity NP_445110.1 similar to GB:M57689 SP:P24139 GB:X56347 PID:143606 PID:40007; identified by sequence similarity NP_445111.1 similar to SP:P24138 GB:X56347 PID:580897 GB:AL009126; identified by sequence similarity NP_445112.1 similar to GB:M57689 SP:P24141 GB:X56347 PID:143603 PID:40005; identified by sequence similarity NP_445113.1 similar to GB:M57689 SP:P24141 GB:X56347 PID:143603 PID:40005; identified by sequence similarity NP_445114.1 similar to GB:M57689 SP:P24141 GB:X56347 PID:143603 PID:40005; identified by sequence similarity NP_445115.1 similar to GB:M57689 SP:P24141 GB:X56347 PID:143603 PID:40005; identified by sequence similarity NP_445116.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_445117.1 similar to GB:M17532 SP:P15282 GB:X13968 PID:145356 PID:43307; identified by sequence similarity NP_445118.1 similar to SP:P10345 PID:41572 GB:U00096 PID:1651370 PID:1787030; identified by sequence similarity NP_445119.1 similar to SP:P41076 PID:624632 GB:U00096 PID:1651271 PID:1778570; identified by sequence similarity NP_445120.1 hypothetical protein; identified by Glimmer2 NP_445121.1 conserved hypothetical protein; identified by Glimmer2 NP_445122.1 conserved hypothetical protein; identified by Glimmer2 NP_445123.1 conserved hypothetical protein; identified by Glimmer2 NP_445124.1 hypothetical protein; identified by Glimmer2 NP_445125.1 hypothetical protein; identified by Glimmer2 NP_445126.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate NP_445127.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_445128.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_445129.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_445130.1 hypothetical protein; identified by Glimmer2 NP_445131.1 hypothetical protein; identified by Glimmer2 NP_445132.1 hypothetical protein; identified by Glimmer2 NP_445133.1 hypothetical protein; identified by Glimmer2 NP_445134.1 hypothetical protein; identified by Glimmer2 NP_445135.1 hypothetical protein; identified by Glimmer2 NP_445136.1 MAC/perforin family protein; identified by match to PFAM protein family HMM PF01823 NP_445137.1 hypothetical protein; identified by Glimmer2 NP_445138.1 hypothetical protein; identified by Glimmer2 NP_445139.1 hypothetical protein; identified by Glimmer2 NP_445140.1 hypothetical protein; identified by Glimmer2 NP_445141.1 similar to GB:M10101 SP:P04079 PID:146276 GB:U00096 PID:1788854; identified by sequence similarity NP_445142.1 hypothetical protein; identified by Glimmer2 NP_445143.1 hypothetical protein; identified by Glimmer2 NP_445144.1 hypothetical protein; identified by Glimmer2 NP_445145.1 hypothetical protein; identified by Glimmer2 NP_445146.1 hypothetical protein; identified by Glimmer2 NP_445147.1 hypothetical protein; identified by Glimmer2 NP_445148.1 hypothetical protein; identified by Glimmer2 NP_445149.1 hypothetical protein; identified by Glimmer2 NP_445150.1 hypothetical protein; identified by Glimmer2 NP_445151.1 hypothetical protein; identified by Glimmer2 NP_445152.1 similar to GP:6458779; identified by sequence similarity NP_445153.1 catalyzes the formation of fructose 1,6-bisphosphate from fructose 6-phosphate and diphosphate NP_445154.1 hypothetical protein; identified by Glimmer2 NP_445155.1 similar to GB:X80061 PID:510823; identified by sequence similarity NP_445156.1 hypothetical protein; identified by Glimmer2 NP_445157.1 similar to GB:X80061 PID:510823; identified by sequence similarity NP_445158.1 hypothetical protein; identified by Glimmer2 NP_445159.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A NP_445160.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_445161.1 hypothetical protein; identified by Glimmer2 NP_445162.1 conserved hypothetical protein; identified by Glimmer2 NP_445163.1 hypothetical protein; identified by Glimmer2 NP_445164.1 conserved hypothetical protein; identified by Glimmer2 NP_445165.1 conserved hypothetical protein; identified by Glimmer2 NP_445166.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_445167.1 conserved hypothetical protein; identified by Glimmer2 NP_445168.1 hypothetical protein; identified by Glimmer2 NP_445169.1 hypothetical protein; identified by Glimmer2 NP_445170.1 conserved hypothetical protein; identified by Glimmer2 NP_445171.1 similar to GB:M29364 SP:P03815 GB:V00350 GB:X57620 PID:1236633; identified by sequence similarity NP_445172.1 conserved hypothetical protein; identified by Glimmer2 NP_445173.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_445174.1 conserved hypothetical protein; identified by Glimmer2 NP_445175.1 similar to GP:5817606; identified by sequence similarity NP_445176.1 catalyzes the formation of 5-aminolevulinate from (S)-4-amino-5-oxopentanoate NP_445177.1 conserved hypothetical protein; identified by Glimmer2 NP_445178.1 similar to GB:Z32522 PID:510140 SP:P54124 PID:1771208; identified by sequence similarity NP_445179.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring NP_445180.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_445181.1 conserved hypothetical protein; identified by Glimmer2 NP_445182.1 hypothetical protein; identified by Glimmer2 NP_445183.1 hypothetical protein; identified by Glimmer2 NP_445184.1 hypothetical protein; identified by Glimmer2 NP_445185.1 similar to PID:1419219 PID:1431219 PID:886081; identified by sequence similarity NP_445186.1 hypothetical protein; identified by Glimmer2 NP_445187.1 conserved hypothetical protein; identified by Glimmer2 NP_445188.1 hypothetical protein; identified by Glimmer2 NP_445189.1 hypothetical protein; identified by Glimmer2 NP_445190.1 hypothetical protein; identified by Glimmer2 NP_445191.1 hypothetical protein; identified by Glimmer2 NP_445192.1 similar to SP:P04993 GB:X04581 GB:X04582 PID:42683 PID:42691; identified by sequence similarity NP_445193.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_445194.1 conserved hypothetical protein; identified by Glimmer2 NP_445195.1 Essential for recycling GMP and indirectly, cGMP NP_445196.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_445197.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_445198.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; Chlamydial proteins show a C-terminal extension of unknown function NP_445199.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_445200.1 similar to SP:P07019 PID:43142 GB:U00096 PID:1788963; identified by sequence similarity NP_445201.1 HemK; PrmC; transfers a methyl group from S-adenosyl-methionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB possibly stimulating release of completed polypeptide chains NP_445202.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_445203.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_445204.1 conserved hypothetical protein; identified by Glimmer2 NP_445205.1 hypothetical protein; identified by Glimmer2 NP_445206.1 similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096; identified by sequence similarity NP_445207.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) NP_445208.1 conserved hypothetical protein; identified by Glimmer2 NP_445209.1 hypothetical protein; identified by Glimmer2 NP_445210.2 similar to GB:U00096 PID:1778579 PID:1786881; identified by sequence similarity NP_445211.1 conserved hypothetical protein; identified by Glimmer2 NP_445212.1 conserved hypothetical protein; identified by Glimmer2 NP_445213.1 similar to GB:U00096 PID:1651480 PID:1787213; identified by sequence similarity NP_445214.1 similar to GB:U00096 PID:1651479 PID:1787212; identified by sequence similarity NP_445215.1 conserved hypothetical protein; identified by Glimmer2 NP_445216.1 conserved hypothetical protein; identified by Glimmer2 NP_445217.1 hypothetical protein; identified by Glimmer2 NP_445218.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA NP_445219.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_445220.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_445221.1 PknD; responsible for phosphorylation of proteins on serine and threonine residues; similar to eukaryotic Ser/Thr kinases; in Chlamydia trachomatis itseems to interact with Pkn1, another serine/threonine-protein kinase NP_445222.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_445223.1 conserved hypothetical protein; identified by Glimmer2 NP_445224.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits NP_445225.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel. NP_445226.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex NP_445227.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex NP_445228.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex NP_445229.1 conserved hypothetical protein; identified by Glimmer2 NP_445230.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the E subunit is part of the catalytic core of the ATP synthase complex NP_445231.1 hypothetical protein; identified by Glimmer2 NP_445232.1 conserved hypothetical protein; identified by Glimmer2 NP_445233.1 conserved hypothetical protein; identified by Glimmer2 NP_445234.1 Maintains the balance of metabolites in the pentose-phosphate pathway NP_445235.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_445236.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_445237.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_445238.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_445239.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_445240.1 binds directly to 23S ribosomal RNA NP_445241.1 Modulates Rho-dependent transcription termination NP_445242.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_445243.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_445244.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_445245.1 conserved hypothetical protein; identified by Glimmer2 NP_445246.1 conserved hypothetical protein; identified by Glimmer2 NP_445247.1 hypothetical protein; identified by Glimmer2 NP_445248.1 hypothetical protein; identified by Glimmer2 NP_445249.1 hypothetical protein; identified by Glimmer2 NP_445250.1 hypothetical protein; identified by Glimmer2 NP_445251.1 conserved hypothetical protein; identified by Glimmer2 NP_445252.1 hypothetical protein; identified by Glimmer2 NP_445253.1 hypothetical protein; identified by Glimmer2 NP_445254.1 hypothetical protein; identified by Glimmer2 NP_445255.1 conserved hypothetical protein; identified by Glimmer2 NP_445256.1 PTS system, IIA component; identified by match to PFAM protein family HMM PF00359 NP_445257.1 PTS system, IIA component; identified by match to PFAM protein family HMM PF00359 NP_445258.1 catalyzes the formation of dUMP from dUTP NP_445259.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_445260.1 similar to SP:P31161 PID:1408318 PID:1627745 PID:217298; identified by sequence similarity NP_445261.1 phosphoglucomutase/phosphomannomutase, ; identified by match to PFAM protein family HMM PF00408 NP_445262.1 conserved hypothetical protein; identified by Glimmer2 NP_445263.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_445264.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents NP_445265.1 transformation of prophobilinogen to hydroxymethylbilane in porphyrin biosynthesis NP_445266.1 hypothetical protein; identified by Glimmer2 NP_445267.1 hypothetical protein; identified by Glimmer2 NP_445268.1 conserved hypothetical protein; identified by Glimmer2 NP_445269.1 hypothetical protein; identified by Glimmer2 NP_445270.1 hypothetical protein; identified by Glimmer2 NP_445271.1 hypothetical protein; identified by Glimmer2 NP_445272.1 hypothetical protein; identified by Glimmer2 NP_445273.1 hypothetical protein; identified by Glimmer2 NP_445274.1 hypothetical protein; identified by Glimmer2 NP_445275.1 hypothetical protein; identified by Glimmer2 NP_445276.1 hypothetical protein; identified by Glimmer2 NP_445277.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_445278.1 conserved hypothetical protein; identified by Glimmer2 NP_445279.1 similar to SP:P42014 PID:529003; identified by sequence similarity NP_445280.1 similar to SP:P08877 PID:48682 GB:AL009126; identified by sequence similarity NP_445281.1 conserved hypothetical protein; identified by Glimmer2 NP_445282.1 hypothetical protein; identified by Glimmer2 NP_445283.1 conserved hypothetical protein; identified by Glimmer2 NP_445284.1 hypothetical protein; identified by Glimmer2 NP_445285.1 similar to GB:M97391 SP:P37941 PID:142612 PID:1303943 GB:AL009126; identified by sequence similarity NP_445286.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_445287.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_445288.1 conserved hypothetical protein; identified by Glimmer2 NP_445289.1 hypothetical protein; identified by Glimmer2 NP_445290.1 hypothetical protein; identified by Glimmer2 NP_445291.1 similar to SP:P36777 PID:414046 PID:429100; identified by sequence similarity NP_445292.1 hypothetical protein; identified by Glimmer2 NP_445293.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions NP_445294.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_445295.1 ABC transporter ATP-binding protein; identified by match to PFAM protein family HMM PF00005 NP_445296.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell NP_445297.1 conserved hypothetical protein; identified by Glimmer2 NP_445298.1 conserved hypothetical protein; identified by Glimmer2 NP_445299.1 hypothetical protein; identified by Glimmer2 NP_445300.1 similar to GP:4376270; identified by sequence similarity NP_445301.1 hypothetical protein; identified by Glimmer2 NP_445302.1 hypothetical protein; identified by Glimmer2 NP_445303.1 hypothetical protein; identified by Glimmer2 NP_445304.1 hypothetical protein; identified by Glimmer2 NP_445305.1 hypothetical protein; identified by Glimmer2 NP_445306.1 hypothetical protein; identified by Glimmer2 NP_445307.1 hypothetical protein; identified by Glimmer2 NP_445308.1 hypothetical protein; identified by Glimmer2 NP_445309.1 similar to GP:4376260; identified by sequence similarity NP_445310.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_445311.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_445312.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_445313.1 hypothetical protein; identified by Glimmer2 NP_445314.1 conserved hypothetical protein; identified by Glimmer2 NP_445315.1 conserved hypothetical protein; identified by Glimmer2 NP_445316.1 conserved hypothetical protein; identified by Glimmer2 NP_445317.1 hypothetical protein; identified by Glimmer2 NP_445318.1 hypothetical protein; identified by Glimmer2 NP_445319.1 hypothetical protein; identified by Glimmer2 NP_445320.1 conserved hypothetical protein; identified by Glimmer2 NP_445321.2 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_445322.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_445323.1 hypothetical protein; identified by Glimmer2 NP_445324.1 hypothetical protein; identified by Glimmer2 NP_445325.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_445326.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_445327.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_445328.1 conserved hypothetical protein; identified by Glimmer2 NP_445329.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate NP_445330.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_445331.1 conserved hypothetical protein; identified by Glimmer2 NP_445332.1 conserved hypothetical protein; identified by Glimmer2 NP_445333.1 hypothetical protein; identified by Glimmer2 NP_445334.1 hypothetical protein; identified by Glimmer2 NP_445335.1 hypothetical protein; identified by Glimmer2 NP_445336.1 hypothetical protein; identified by Glimmer2 NP_445337.1 hypothetical protein; identified by Glimmer2 NP_445338.1 hypothetical protein; identified by Glimmer2 NP_445339.1 hypothetical protein; identified by Glimmer2 NP_445340.1 hypothetical protein; identified by Glimmer2 NP_445341.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_445342.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP NP_445343.1 catalyzes the formation of aspartate semialdehyde from aspartyl phosphate NP_445344.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_445345.1 catalyzes the formation of tyrosine, dihydroxyphenylalanine, and 5-hydroxytryptophan from phenylalanine, tyrosine, and tryptophan respectively NP_445346.1 conserved hypothetical protein; identified by Glimmer2 NP_445347.1 similar to GB:J04423 SP:P12996 PID:145425 PID:490219 GB:U00096; identified by sequence similarity NP_445348.1 similar to GB:AL009126; identified by sequence similarity NP_445349.1 similar to SP:P53558 PID:1277028 PID:2293186 GB:AL009126; identified by sequence similarity NP_445350.1 similar to GB:J04423 SP:P12995 PID:457106 PID:490217 GB:U00096; identified by sequence similarity NP_445351.1 hypothetical protein; identified by Glimmer2 NP_445352.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_445353.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis NP_445354.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_445355.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_445356.1 AroDE; bifunctional enzyme; can convert 3-dehydroquinate to 3-dehydroshkimate and then to shikimate; involved in the synthesis of aromatic amino acids and other metabolites; type I 3-DHQase NP_445357.1 conserved hypothetical protein; identified by Glimmer2 NP_445358.1 conserved hypothetical protein; identified by Glimmer2 NP_445359.1 conserved hypothetical protein; identified by Glimmer2 NP_445360.1 amino acid permease; identified by match to PFAM protein family HMM PF00324 NP_445361.1 oxidoreductase, DadA family; identified by match to PFAM protein family HMM PF01266 NP_445362.1 hypothetical protein; identified by Glimmer2 NP_445363.1 catalyzes the oxidation of malate to oxaloacetate NP_445364.1 hypothetical protein; identified by Glimmer2 NP_445365.1 conserved hypothetical protein; identified by Glimmer2 NP_445366.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_445367.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_445368.1 hypothetical protein; identified by Glimmer2 NP_445369.1 hypothetical protein; identified by Glimmer2 NP_445370.1 conserved hypothetical protein; identified by Glimmer2 NP_445371.1 similar to GB:M26405 SP:P21207 PID:155451; identified by sequence similarity NP_445372.1 conserved hypothetical protein; identified by Glimmer2 NP_445373.1 conserved hypothetical protein; identified by Glimmer2 NP_445374.1 hypothetical protein; identified by Glimmer2 NP_445375.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway NP_445376.1 conserved hypothetical protein; identified by Glimmer2 NP_445377.1 similar to GP:3123728; identified by sequence similarity NP_445378.1 sulfate transporter family protein; identified by match to PFAM protein family HMM PF00916 NP_445379.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle NP_445380.1 similar to GB:AE001273; identified by sequence similarity NP_445381.1 conserved hypothetical protein; identified by Glimmer2 NP_445382.2 catalyzes the removal of N-terminal amino acids from peptides and arylamides NP_445383.1 conserved hypothetical protein; identified by Glimmer2 NP_445384.1 conserved hypothetical protein; identified by Glimmer2 NP_445385.1 conserved hypothetical protein; identified by Glimmer2 NP_445386.1 conserved hypothetical protein; identified by Glimmer2 NP_445387.1 conserved hypothetical protein; identified by Glimmer2 NP_445388.1 conserved hypothetical protein; identified by Glimmer2 NP_445389.1 conserved hypothetical protein; identified by Glimmer2 NP_445390.1 cytidine/deoxycytidylate deaminase family protein; identified by match to PFAM protein family HMM PF00383 NP_445391.1 hypothetical protein; identified by Glimmer2 NP_445392.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_445393.1 similar to GB:J02638 SP:P05055 GB:M14425 GB:X00761 PID:147749; identified by sequence similarity NP_445394.1 hypothetical protein; identified by Glimmer2 NP_445395.1 similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116; identified by sequence similarity NP_445396.1 similar to GB:U00096 PID:1552765 PID:1786386 PID:971394; identified by sequence similarity NP_445397.1 conserved hypothetical protein; identified by Glimmer2 NP_445398.1 conserved hypothetical protein; identified by Glimmer2 NP_445399.1 conserved hypothetical protein; identified by Glimmer2 NP_445400.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_445401.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_445402.1 similar to GB:M76589 SP:P49240 PID:868029; identified by sequence similarity NP_445403.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_445404.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_445405.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_445406.1 conserved hypothetical protein; identified by Glimmer2 NP_445407.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_445408.1 hypothetical protein; identified by Glimmer2 NP_445409.1 Catalyzes the rate-limiting step in dNTP synthesis NP_445410.1 catalyzes the rate-limiting step in dNTP synthesis NP_445411.1 similar to GB:AE000511 SP:Q48269 PID:1477770 PID:2199520 PID:2253274; identified by sequence similarity NP_445412.1 conserved hypothetical protein; identified by Glimmer2 NP_445413.1 similar to GP:3779244; identified by sequence similarity NP_445414.1 peptidase, M20/M25/M40 family; identified by match to PFAM protein family HMM PF01546 NP_445415.1 similar to GB:M36536 SP:P09376 GB:M29955 GB:X12457 PID:146414; identified by sequence similarity NP_445416.1 hypothetical protein; identified by Glimmer2 NP_445417.1 hypothetical protein; identified by Glimmer2 NP_445418.1 hypothetical protein; identified by Glimmer2 NP_445419.1 hypothetical protein; identified by Glimmer2 NP_445420.1 hypothetical protein; identified by Glimmer2 NP_445421.1 hypothetical protein; identified by Glimmer2 NP_445422.1 hypothetical protein; identified by Glimmer2 NP_445423.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle NP_445424.1 catalyzes the interconversion of succinyl-CoA and succinate NP_445425.1 similar to SP:P10121 GB:U00039 GB:X04398 PID:41498 PID:466600; identified by sequence similarity NP_445426.1 conserved hypothetical protein; identified by Glimmer2 NP_445427.1 similar to GB:M23240 SP:P18199 PID:148089 GB:U00096 PID:1736569; identified by sequence similarity NP_445428.1 hypothetical protein; identified by Glimmer2 NP_445429.1 similar to GB:M23240 SP:P18199 PID:148089 GB:U00096 PID:1736569; identified by sequence similarity NP_445430.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_445431.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_445432.1 similar to SP:P13685 GB:D26562 GB:M20574 GB:S48039 PID:147117; identified by sequence similarity NP_445433.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate; lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM NP_445434.1 hypothetical protein; identified by Glimmer2 NP_445435.1 similar to GP:4377287; identified by sequence similarity NP_445436.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_445437.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_445438.1 conserved hypothetical protein; identified by Glimmer2 NP_445439.1 similar to SP:P44443; identified by sequence similarity NP_445440.1 similar to PID:167519; identified by sequence similarity NP_445441.1 similar to GP:18455; identified by sequence similarity NP_445442.1 conserved hypothetical protein; identified by Glimmer2 NP_445443.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_445444.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_445445.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_445446.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_445447.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response NP_445448.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose NP_445449.1 similar to GB:M12299 SP:P06978 PID:473749 GB:U00096 PID:1736571; identified by sequence similarity NP_445450.1 similar to GP:2654226; identified by sequence similarity NP_445451.1 conserved hypothetical protein; identified by Glimmer2 NP_445452.1 hypothetical protein; identified by Glimmer2 NP_445453.1 hypothetical protein; identified by Glimmer2 NP_445454.1 conserved hypothetical protein; identified by Glimmer2 NP_445455.1 hypothetical protein; identified by Glimmer2 NP_445456.1 synthesizes RNA primers at the replication forks NP_445457.1 This protein performs the mismatch recognition step during the DNA repair process NP_445458.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_445459.1 conserved hypothetical protein; identified by Glimmer2 NP_445460.1 conserved hypothetical protein; identified by Glimmer2 NP_445461.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_445462.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif NP_445463.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_445464.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_445465.1 conserved hypothetical protein; identified by Glimmer2 NP_445466.1 hypothetical protein; identified by Glimmer2 NP_445467.1 hypothetical protein; identified by Glimmer2 NP_445468.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_445469.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_445470.1 hypothetical protein; identified by Glimmer2 NP_445471.1 hypothetical protein; identified by Glimmer2 NP_445472.1 hypothetical protein; identified by Glimmer2 NP_445473.1 hypothetical protein; identified by Glimmer2 NP_445474.1 conserved hypothetical protein; identified by Glimmer2 NP_445475.1 conserved hypothetical protein; identified by Glimmer2 NP_445476.1 conserved hypothetical protein; identified by Glimmer2 NP_445477.1 conserved hypothetical protein; identified by Glimmer2 NP_445478.1 conserved hypothetical protein; identified by Glimmer2 NP_445479.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity NP_445480.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine NP_445481.1 Synthesizes thioester adducts of fatty acids enzymatically to the phosphopantetheine group of acyl carrier protein NP_445482.1 conserved hypothetical protein; identified by Glimmer2 NP_445483.1 similar to GB:U33283 PID:1109672; identified by sequence similarity NP_445484.1 Glu/Leu/Phe/Val dehydrogenase family protein; identified by match to PFAM protein family HMM PF00208 NP_445485.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_445486.1 similar to GB:U30313 SP:P50583 PID:1050961; identified by sequence similarity NP_445487.1 FabF, beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP. NP_445488.1 iojap-related protein; identified by match to TIGR protein family HMM TIGR00090 NP_445489.1 hypothetical protein; identified by Glimmer2 NP_445490.1 hypothetical protein; identified by Glimmer2 NP_445491.1 conserved hypothetical protein; identified by Glimmer2 NP_445492.1 conserved hypothetical protein; identified by Glimmer2 NP_445493.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_445494.1 anti-anti-sigma factor; identified by match to PFAM protein family HMM PF01740 NP_445495.1 conserved hypothetical protein; identified by Glimmer2 NP_445496.1 similar to SP:P36654 GB:X77707 GB:Z36905 PID:535291 PID:536981; identified by sequence similarity NP_445497.1 conserved hypothetical protein; identified by Glimmer2 NP_445498.1 catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine and catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis NP_445499.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_445500.1 similar to SP:P07373 GB:D14109 GB:M15742 GB:X51419 GB:X64259; identified by sequence similarity NP_445501.1 conserved hypothetical protein; identified by Glimmer2 NP_445502.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_445503.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_445504.1 similar to GB:D10483 SP:P11880 PID:216500 PID:40854 PID:42048; identified by sequence similarity NP_445505.1 similar to SP:P26821 GB:X62914 PID:40572; identified by sequence similarity NP_445506.1 conserved hypothetical protein; identified by Glimmer2 NP_445507.1 conserved hypothetical protein; identified by Glimmer2 NP_445508.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_445509.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile NP_445510.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_445511.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_445512.1 similar to SP:P30958 GB:U00096 PID:1651547 PID:1651549 PID:1787357; identified by sequence similarity NP_445513.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III NP_445514.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_445515.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX NP_445516.1 conserved hypothetical protein; identified by Glimmer2 NP_445517.1 similar to GB:M60902 SP:Q02281 GB:X57311 PID:144507 PID:40689; identified by sequence similarity NP_445518.1 similar to SP:P55137 PID:1209277 GB:AE001273; identified by sequence similarity NP_445519.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex NP_445520.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm NP_445521.1 hypothetical protein; identified by Glimmer2 NP_445522.1 hypothetical protein; identified by Glimmer2 NP_445523.1 hypothetical protein; identified by Glimmer2 NP_445524.1 hypothetical protein; identified by Glimmer2 NP_445525.1 hypothetical protein; identified by Glimmer2 NP_445526.1 similar to SP:P46889 PID:1004225 GB:U00096 PID:1651412 PID:1651418; identified by sequence similarity NP_445527.1 conserved hypothetical protein; identified by Glimmer2 NP_445528.1 conserved hypothetical protein; identified by Glimmer2 NP_445529.1 conserved hypothetical protein; identified by Glimmer2 NP_445530.1 sodium/alanine symporter family protein; identified by match to PFAM protein family HMM PF01235 NP_445531.1 conserved hypothetical protein; identified by Glimmer2 NP_445532.1 conserved hypothetical protein; identified by Glimmer2 NP_445533.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_445534.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate NP_445535.1 similar to GB:L09228 SP:P17618 GB:X51510 PID:40085 PID:410125; identified by sequence similarity NP_445536.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_445537.1 conserved hypothetical protein; identified by Glimmer2 NP_445538.1 similar to GB:L28104 PID:495646; identified by sequence similarity NP_445539.1 similar to GB:M22857 SP:P15035 PID:147695 GB:U00096 PID:1651261; identified by sequence similarity NP_445540.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon NP_445541.1 conserved hypothetical protein; identified by Glimmer2 NP_445542.1 similar to GB:L09228 SP:P35159 PID:410137 GB:AL009126; identified by sequence similarity NP_445543.1 catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_445544.1 similar to SP:P55690 PID:2182702; identified by sequence similarity NP_445545.1 similar to SP:P20628 PID:142038; identified by sequence similarity NP_445546.1 conserved hypothetical protein; identified by Glimmer2 NP_445547.1 conserved hypothetical protein; identified by Glimmer2 NP_445548.1 involved in type III protein export NP_445549.1 conserved hypothetical protein; identified by Glimmer2 NP_445550.1 similar to SP:O64765; identified by sequence similarity NP_445551.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_445552.1 similar to PIR:S16034; identified by sequence similarity NP_445553.1 conserved hypothetical protein; identified by Glimmer2 NP_445554.1 conserved hypothetical protein; identified by Glimmer2 NP_445555.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP NP_445556.1 similar to GB:M95582 SP:Q01465 GB:M96343 PID:142855 PID:143212; identified by sequence similarity NP_445557.1 helicase, Snf2 family; identified by match to PFAM protein family HMM PF00271 NP_445558.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_445559.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates NP_445560.1 binds and unfolds substrates as part of the ClpXP protease NP_445561.1 similar to SP:P13685 GB:D26562 GB:M20574 GB:S48039 PID:147117; identified by sequence similarity NP_445562.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_445563.1 conserved hypothetical protein; identified by Glimmer2 NP_445564.1 hypothetical protein; identified by Glimmer2 NP_445565.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_445566.1 conserved hypothetical protein; identified by Glimmer2 NP_445567.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine NP_445568.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_445569.1 similar to GB:J02857 SP:P20625 PID:146972 GB:U00096 PID:1742691; identified by sequence similarity NP_445570.1 similar to PID:732813 SP:P54104; identified by sequence similarity NP_445571.1 similar to GP:3738215; identified by sequence similarity NP_445572.1 conserved hypothetical protein; identified by Glimmer2 NP_445573.1 hypothetical protein; identified by Glimmer2 NP_445574.1 E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide NP_445575.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group NP_445576.1 hypothetical protein; identified by Glimmer2 NP_445577.1 hypothetical protein; identified by Glimmer2 NP_445578.1 hypothetical protein; identified by Glimmer2 NP_445579.1 hypothetical protein; identified by Glimmer2 NP_445580.1 similar to PID:1336088; identified by sequence similarity NP_445581.1 conserved hypothetical protein; identified by Glimmer2 NP_445582.1 similar to GB:M74011 SP:Q01253 PID:155561 PID:155562 PID:155563; identified by sequence similarity NP_445583.1 similar to GB:L22495 PID:349175; identified by sequence similarity NP_445584.1 type III secretion inner membrane protein SctS; identified by match to PFAM protein family HMM PF01313 NP_445585.1 type III secretion inner membrane protein SctT; identified by match to PFAM protein family HMM PF01311 NP_445586.1 conserved hypothetical protein; identified by Glimmer2 NP_445587.1 conserved hypothetical protein; identified by Glimmer2 NP_445588.1 conserved hypothetical protein; identified by Glimmer2 NP_445589.1 Conserved hypothetical protein; identified by Glimmer2 NP_445590.1 conserved hypothetical protein; identified by Glimmer2 NP_445591.1 similar to SP:Q00513 GB:X62666 PID:45435; identified by sequence similarity NP_445592.1 similar to SP:Q00512 GB:X62666 PID:45434; identified by sequence similarity NP_445593.1 similar to SP:Q01565 SP:P31700 GB:X65265 PID:581156; identified by sequence similarity NP_445594.1 conserved hypothetical protein; identified by Glimmer2 NP_445595.1 similar to GP:3372642; identified by sequence similarity NP_445596.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_445597.1 similar to GB:M26405 SP:P21207 PID:155451; identified by sequence similarity NP_445598.1 conserved hypothetical protein; identified by Glimmer2 NP_445599.1 conserved hypothetical protein; identified by Glimmer2 NP_445600.1 conserved hypothetical protein; identified by Glimmer2 NP_445601.1 membrane protein, ; identified by match to PFAM protein family HMM PF00892 NP_445602.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_445603.1 similar to GB:D26185 SP:P37522 PID:467381 PID:580906 GB:AL009126; identified by sequence similarity NP_445604.1 similar to SP:P10560 GB:X07547 GB:X54450 GB:X54451 PID:581014; identified by sequence similarity NP_445605.1 conserved hypothetical protein; identified by Glimmer2 NP_445606.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_445607.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_445608.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_445609.1 hypothetical protein; identified by Glimmer2 NP_445610.1 hypothetical protein; identified by Glimmer2 NP_445611.1 hypothetical protein; identified by Glimmer2 NP_445612.1 hypothetical protein; identified by Glimmer2 NP_445613.1 hypothetical protein; identified by Glimmer2 NP_445614.1 hypothetical protein; identified by Glimmer2 NP_445615.1 hypothetical protein; identified by Glimmer2 NP_445616.1 similar to SP:P37979; identified by sequence similarity NP_445617.1 conserved hypothetical protein; identified by Glimmer2 NP_445618.1 conserved hypothetical protein; identified by Glimmer2 NP_445619.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase NP_445620.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol NP_445621.1 similar to GB:M13470 SP:P08064 PID:143525 PID:1770051 GB:AL009126; identified by sequence similarity NP_445622.1 similar to GP:3193220; identified by sequence similarity NP_445623.1 similar to SP:P36655 GB:X77707 GB:Z36905 PID:536980 PID:581055; identified by sequence similarity NP_445624.1 MotA/TolQ/ExbB proton channel family protein; identified by match to PFAM protein family HMM PF01618 NP_445625.1 similar to GB:M28819 SP:P18784 PID:145869 PID:882534 GB:U00096; identified by sequence similarity NP_445626.1 conserved hypothetical protein; identified by Glimmer2 NP_445627.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA NP_445628.1 similar to SP:P07176 PID:41360 PID:42257 GB:U00096 PID:1651333; identified by sequence similarity NP_445629.1 similar to SP:P54421 PID:1488662; identified by sequence similarity NP_445630.1 conserved hypothetical protein; identified by Glimmer2 NP_445631.1 antioxidant, AhpC/Tsa family; identified by match to PFAM protein family HMM PF00578 NP_445632.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth NP_445633.1 conserved hypothetical protein; identified by Glimmer2 NP_445634.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine NP_445635.1 conserved hypothetical protein; identified by Glimmer2 NP_445636.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_445637.1 similar to GB:M63176 PID:153062 SP:Q53727; identified by sequence similarity NP_445638.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen NP_445639.1 conserved hypothetical protein; identified by Glimmer2 NP_445640.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_445641.1 conserved hypothetical protein; identified by Glimmer2 NP_445642.1 conserved hypothetical protein; identified by Glimmer2 NP_445643.1 conserved hypothetical protein; identified by Glimmer2 NP_445644.1 conserved hypothetical protein; identified by Glimmer2 NP_445645.1 conserved hypothetical protein; identified by Glimmer2 NP_445646.1 5-formyltetrahydrofolate cyclo-ligase, ; identified by match to PFAM protein family HMM PF01812 NP_445647.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_445648.1 similar to SP:P07780 GB:X06452 PID:38743; identified by sequence similarity NP_445649.1 conserved hypothetical protein; identified by Glimmer2 NP_445650.1 similar to GB:D10483 SP:P00379 GB:J01609 GB:V00276 GB:X05108; identified by sequence similarity NP_445651.1 similar to GB:AE001273; identified by sequence similarity NP_445652.1 similar to PID:2160684; identified by sequence similarity NP_445653.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released NP_445654.1 conserved hypothetical protein; identified by Glimmer2 NP_445655.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_445656.1 conserved hypothetical protein; identified by Glimmer2 NP_445657.1 similar to SP:P04993 GB:X04581 GB:X04582 PID:42683 PID:42691; identified by sequence similarity NP_445658.1 conserved hypothetical protein; identified by Glimmer2 NP_445659.1 transcriptional regulator; identified by match to PFAM protein family HMM PF00486 NP_445660.1 hypothetical protein; identified by Glimmer2 NP_445661.1 similar to SP:P17114 PID:290578 PID:43267 PID:290579 GB:U00096; identified by sequence similarity NP_445662.1 similar to PID:1063276; identified by sequence similarity NP_445663.1 conserved hypothetical protein; identified by Glimmer2 NP_445664.1 hypothetical protein; identified by Glimmer2 NP_445665.1 hypothetical protein; identified by Glimmer2