-- dump date 20120504_141731 -- class Genbank::misc_feature -- table misc_feature_note -- id note 331678000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 331678000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 331678000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000004 Walker A motif; other site 331678000005 ATP binding site [chemical binding]; other site 331678000006 Walker B motif; other site 331678000007 arginine finger; other site 331678000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 331678000009 DnaA box-binding interface [nucleotide binding]; other site 331678000010 DNA polymerase III subunit beta; Provisional; Region: PRK14941 331678000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 331678000012 putative DNA binding surface [nucleotide binding]; other site 331678000013 dimer interface [polypeptide binding]; other site 331678000014 beta-clamp/clamp loader binding surface; other site 331678000015 beta-clamp/translesion DNA polymerase binding surface; other site 331678000016 recombination protein F; Reviewed; Region: recF; PRK00064 331678000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000018 Walker A/P-loop; other site 331678000019 ATP binding site [chemical binding]; other site 331678000020 Q-loop/lid; other site 331678000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000022 ABC transporter signature motif; other site 331678000023 Walker B; other site 331678000024 D-loop; other site 331678000025 H-loop/switch region; other site 331678000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 331678000027 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331678000028 active site 331678000029 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 331678000030 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331678000031 putative substrate binding region [chemical binding]; other site 331678000032 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 331678000033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331678000034 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 331678000035 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 331678000036 DNA polymerase type-B family; Region: POLBc; smart00486 331678000037 active site 331678000038 catalytic site [active] 331678000039 substrate binding site [chemical binding]; other site 331678000040 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 331678000041 active site 331678000042 metal-binding site 331678000043 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 331678000044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000046 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 331678000047 Cytochrome c; Region: Cytochrom_C; cl11414 331678000048 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331678000049 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 331678000050 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 331678000051 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 331678000052 Protein export membrane protein; Region: SecD_SecF; cl14618 331678000053 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 331678000054 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 331678000055 Protein export membrane protein; Region: SecD_SecF; cl14618 331678000056 SurA N-terminal domain; Region: SurA_N_3; cl07813 331678000057 PPIC-type PPIASE domain; Region: Rotamase; cl08278 331678000058 PPIC-type PPIASE domain; Region: Rotamase; cl08278 331678000059 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 331678000060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678000061 ATP binding site [chemical binding]; other site 331678000062 Mg2+ binding site [ion binding]; other site 331678000063 G-X-G motif; other site 331678000064 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 331678000065 anchoring element; other site 331678000066 dimer interface [polypeptide binding]; other site 331678000067 ATP binding site [chemical binding]; other site 331678000068 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 331678000069 active site 331678000070 putative metal-binding site [ion binding]; other site 331678000071 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 331678000072 Restriction endonuclease; Region: Mrr_cat; cl00516 331678000073 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 331678000074 RNA/DNA hybrid binding site [nucleotide binding]; other site 331678000075 active site 331678000076 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 331678000077 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 331678000078 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678000079 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 331678000080 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 331678000081 trimer interface [polypeptide binding]; other site 331678000082 active site 331678000083 substrate binding site [chemical binding]; other site 331678000084 CoA binding site [chemical binding]; other site 331678000085 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331678000086 C-terminal peptidase (prc); Region: prc; TIGR00225 331678000087 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331678000088 protein binding site [polypeptide binding]; other site 331678000089 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331678000090 Catalytic dyad [active] 331678000091 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 331678000092 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 331678000093 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 331678000094 glycyl-tRNA synthetase; Provisional; Region: PRK04173 331678000095 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 331678000096 motif 1; other site 331678000097 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 331678000098 active site 331678000099 motif 2; other site 331678000100 motif 3; other site 331678000101 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 331678000102 anticodon binding site; other site 331678000103 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678000104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678000105 catalytic residue [active] 331678000106 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 331678000107 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 331678000108 dimer interface [polypeptide binding]; other site 331678000109 catalytic triad [active] 331678000110 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 331678000111 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 331678000112 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 331678000113 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 331678000114 alpha subunit interaction interface [polypeptide binding]; other site 331678000115 Walker A motif; other site 331678000116 ATP binding site [chemical binding]; other site 331678000117 Walker B motif; other site 331678000118 inhibitor binding site; inhibition site 331678000119 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331678000120 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 331678000121 catalytic residues [active] 331678000122 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 331678000123 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 331678000124 active site 331678000125 substrate-binding site [chemical binding]; other site 331678000126 metal-binding site [ion binding] 331678000127 GTP binding site [chemical binding]; other site 331678000128 Dodecin; Region: Dodecin; cl01328 331678000129 DsrE/DsrF-like family; Region: DrsE; cl00672 331678000130 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 331678000131 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 331678000132 P-loop; other site 331678000133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000134 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 331678000135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000136 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 331678000137 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678000138 Transposase domain (DUF772); Region: DUF772; cl15789 331678000139 NlpC/P60 family; Region: NLPC_P60; cl11438 331678000140 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 331678000141 Cytochrome c; Region: Cytochrom_C; cl11414 331678000142 Helix-turn-helix domains; Region: HTH; cl00088 331678000143 Integrase core domain; Region: rve; cl01316 331678000144 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678000145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000146 Walker A motif; other site 331678000147 ATP binding site [chemical binding]; other site 331678000148 Walker B motif; other site 331678000149 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 331678000150 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 331678000151 Protein of unknown function (DUF433); Region: DUF433; cl01030 331678000152 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678000153 oligomeric interface; other site 331678000154 putative active site [active] 331678000155 homodimer interface [polypeptide binding]; other site 331678000156 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 331678000157 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331678000158 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 331678000159 active site 331678000160 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000161 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 331678000162 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 331678000163 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678000164 active site 331678000165 NTP binding site [chemical binding]; other site 331678000166 metal binding triad [ion binding]; metal-binding site 331678000167 antibiotic binding site [chemical binding]; other site 331678000168 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 331678000169 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 331678000170 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 331678000171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678000173 ATP binding site [chemical binding]; other site 331678000174 putative Mg++ binding site [ion binding]; other site 331678000175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678000176 nucleotide binding region [chemical binding]; other site 331678000177 ATP-binding site [chemical binding]; other site 331678000178 RQC domain; Region: RQC; cl09632 331678000179 HRDC domain; Region: HRDC; cl02578 331678000180 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 331678000181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000182 FeS/SAM binding site; other site 331678000183 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 331678000184 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 331678000185 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 331678000186 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 331678000187 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 331678000188 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 331678000189 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 331678000190 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 331678000191 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 331678000192 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 331678000193 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 331678000194 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 331678000195 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 331678000196 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 331678000197 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 331678000198 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 331678000199 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678000200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000201 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 331678000202 Cation transport protein; Region: TrkH; cl10514 331678000203 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 331678000204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000205 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 331678000206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000207 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 331678000208 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 331678000209 SelR domain; Region: SelR; pfam01641 331678000210 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678000211 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678000212 DTAP/Switch II; other site 331678000213 Switch I; other site 331678000214 Ion channel; Region: Ion_trans_2; cl11596 331678000215 peptide chain release factor 1; Validated; Region: prfA; PRK00591 331678000216 RF-1 domain; Region: RF-1; cl02875 331678000217 RF-1 domain; Region: RF-1; cl02875 331678000218 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331678000219 RIP metalloprotease RseP; Region: TIGR00054 331678000220 active site 331678000221 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 331678000222 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 331678000223 protein binding site [polypeptide binding]; other site 331678000224 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331678000225 putative substrate binding region [chemical binding]; other site 331678000226 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 331678000227 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 331678000228 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 331678000229 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 331678000230 Acylphosphatase; Region: Acylphosphatase; cl00551 331678000231 FtsH Extracellular; Region: FtsH_ext; pfam06480 331678000232 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 331678000233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000234 Walker B motif; other site 331678000235 arginine finger; other site 331678000236 Peptidase family M41; Region: Peptidase_M41; pfam01434 331678000237 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 331678000238 active site 331678000239 dimer interface [polypeptide binding]; other site 331678000240 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331678000241 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331678000242 glutaminase active site [active] 331678000243 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331678000244 dimer interface [polypeptide binding]; other site 331678000245 active site 331678000246 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331678000247 dimer interface [polypeptide binding]; other site 331678000248 active site 331678000249 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 331678000250 TIGR01777 family protein; Region: yfcH 331678000251 putative NAD(P) binding site [chemical binding]; other site 331678000252 putative active site [active] 331678000253 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 331678000254 Ferritin-like domain; Region: Ferritin; pfam00210 331678000255 diiron binding motif [ion binding]; other site 331678000256 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678000257 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 331678000258 RNA/DNA binding site [nucleotide binding]; other site 331678000259 RRM dimerization site [polypeptide binding]; other site 331678000260 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 331678000261 Nitrogen regulatory protein P-II; Region: P-II; cl00412 331678000262 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678000263 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 331678000264 active site 331678000265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678000266 binding surface 331678000267 TPR motif; other site 331678000268 TPR repeat; Region: TPR_11; pfam13414 331678000269 ScpA/B protein; Region: ScpA_ScpB; cl00598 331678000270 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 331678000271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000272 S-adenosylmethionine binding site [chemical binding]; other site 331678000273 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678000274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000275 Restriction endonuclease XhoI; Region: XhoI; pfam04555 331678000276 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 331678000277 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 331678000278 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 331678000279 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 331678000280 Oligomerisation domain; Region: Oligomerisation; cl00519 331678000281 DNA gyrase subunit A; Validated; Region: PRK05560 331678000282 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 331678000283 CAP-like domain; other site 331678000284 active site 331678000285 primary dimer interface [polypeptide binding]; other site 331678000286 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000287 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000289 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000290 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000291 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000292 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 331678000293 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 331678000294 CTP synthetase; Validated; Region: pyrG; PRK05380 331678000295 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 331678000296 Catalytic site [active] 331678000297 active site 331678000298 UTP binding site [chemical binding]; other site 331678000299 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 331678000300 active site 331678000301 putative oxyanion hole; other site 331678000302 catalytic triad [active] 331678000303 Ferrochelatase; Region: Ferrochelatase; pfam00762 331678000304 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 331678000305 C-terminal domain interface [polypeptide binding]; other site 331678000306 active site 331678000307 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 331678000308 active site 331678000309 N-terminal domain interface [polypeptide binding]; other site 331678000310 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 331678000311 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678000312 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 331678000313 Putative addiction module component; Region: Unstab_antitox; cl09921 331678000314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678000315 Integrase core domain; Region: rve; cl01316 331678000316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678000317 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000319 Walker A motif; other site 331678000320 ATP binding site [chemical binding]; other site 331678000321 Walker B motif; other site 331678000322 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 331678000323 Phospholipid methyltransferase; Region: PEMT; cl00763 331678000324 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 331678000325 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678000326 Protein of unknown function DUF45; Region: DUF45; cl00636 331678000327 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678000328 Helix-turn-helix domains; Region: HTH; cl00088 331678000329 Integrase core domain; Region: rve; cl01316 331678000330 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 331678000331 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 331678000332 dimer interface [polypeptide binding]; other site 331678000333 active site 331678000334 heme binding site [chemical binding]; other site 331678000335 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 331678000336 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331678000337 metal binding site 2 [ion binding]; metal-binding site 331678000338 putative DNA binding helix; other site 331678000339 metal binding site 1 [ion binding]; metal-binding site 331678000340 dimer interface [polypeptide binding]; other site 331678000341 structural Zn2+ binding site [ion binding]; other site 331678000342 MarC family integral membrane protein; Region: MarC; cl00919 331678000343 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 331678000344 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 331678000345 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 331678000346 active site 331678000347 Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968 331678000348 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331678000349 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331678000350 putative active site [active] 331678000351 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678000352 putative catalytic site [active] 331678000353 putative metal binding site [ion binding]; other site 331678000354 putative phosphate binding site [ion binding]; other site 331678000355 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 331678000356 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 331678000357 dimer interface [polypeptide binding]; other site 331678000358 ssDNA binding site [nucleotide binding]; other site 331678000359 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331678000360 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 331678000361 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 331678000362 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 331678000363 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 331678000364 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 331678000365 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 331678000366 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 331678000367 dimer interface [polypeptide binding]; other site 331678000368 motif 1; other site 331678000369 active site 331678000370 motif 2; other site 331678000371 motif 3; other site 331678000372 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 331678000373 23S rRNA binding site [nucleotide binding]; other site 331678000374 L21 binding site [polypeptide binding]; other site 331678000375 L13 binding site [polypeptide binding]; other site 331678000376 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 331678000377 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 331678000378 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 331678000379 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 331678000380 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 331678000381 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 331678000382 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 331678000383 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 331678000384 active site 331678000385 dimer interface [polypeptide binding]; other site 331678000386 motif 1; other site 331678000387 motif 2; other site 331678000388 motif 3; other site 331678000389 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 331678000390 anticodon binding site; other site 331678000391 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 331678000392 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 331678000393 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 331678000394 Probable beta-xylosidase; Provisional; Region: PLN03080 331678000395 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 331678000396 active site 331678000397 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 331678000398 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 331678000399 dimerization interface [polypeptide binding]; other site 331678000400 active site 331678000401 metal binding site [ion binding]; metal-binding site 331678000402 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 331678000403 dsRNA binding site [nucleotide binding]; other site 331678000404 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 331678000405 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 331678000406 dimer interface [polypeptide binding]; other site 331678000407 active site 331678000408 Phosphopantetheine attachment site; Region: PP-binding; cl09936 331678000409 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 331678000410 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 331678000411 NAD(P) binding site [chemical binding]; other site 331678000412 homotetramer interface [polypeptide binding]; other site 331678000413 homodimer interface [polypeptide binding]; other site 331678000414 active site 331678000415 Acyl transferase domain; Region: Acyl_transf_1; cl08282 331678000416 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 331678000417 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 331678000418 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 331678000419 dimer interface [polypeptide binding]; other site 331678000420 active site 331678000421 CoA binding pocket [chemical binding]; other site 331678000422 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 331678000423 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 331678000424 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 331678000425 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 331678000426 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 331678000427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000428 S-adenosylmethionine binding site [chemical binding]; other site 331678000429 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000430 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678000432 non-specific DNA binding site [nucleotide binding]; other site 331678000433 salt bridge; other site 331678000434 sequence-specific DNA binding site [nucleotide binding]; other site 331678000435 NlpE N-terminal domain; Region: NlpE; cl01138 331678000436 META domain; Region: META; cl01245 331678000437 2-isopropylmalate synthase; Validated; Region: PRK03739 331678000438 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 331678000439 active site 331678000440 catalytic residues [active] 331678000441 metal binding site [ion binding]; metal-binding site 331678000442 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 331678000443 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331678000444 metal binding site 2 [ion binding]; metal-binding site 331678000445 putative DNA binding helix; other site 331678000446 metal binding site 1 [ion binding]; metal-binding site 331678000447 dimer interface [polypeptide binding]; other site 331678000448 structural Zn2+ binding site [ion binding]; other site 331678000449 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 331678000450 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 331678000451 putative metal binding residues [ion binding]; other site 331678000452 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 331678000453 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 331678000454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331678000455 dimer interface [polypeptide binding]; other site 331678000456 putative PBP binding regions; other site 331678000457 ABC-ATPase subunit interface; other site 331678000458 CrcB-like protein; Region: CRCB; cl09114 331678000459 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 331678000460 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 331678000461 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331678000462 inhibitor-cofactor binding pocket; inhibition site 331678000463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000464 catalytic residue [active] 331678000465 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 331678000466 Recombination protein O N terminal; Region: RecO_N; cl15812 331678000467 Recombination protein O C terminal; Region: RecO_C; pfam02565 331678000468 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 331678000469 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 331678000470 OstA-like protein; Region: OstA_2; pfam13100 331678000471 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 331678000472 active site 331678000473 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 331678000474 homodimer interface [polypeptide binding]; other site 331678000475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000477 FeS/SAM binding site; other site 331678000478 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331678000479 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 331678000480 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 331678000481 Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185 331678000482 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 331678000483 Int/Topo IB signature motif; other site 331678000484 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678000485 D5 N terminal like; Region: D5_N; cl07360 331678000486 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 331678000487 Phage terminase, small subunit; Region: Terminase_4; cl01525 331678000488 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 331678000489 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 331678000490 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331678000491 NlpC/P60 family; Region: NLPC_P60; cl11438 331678000492 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 331678000493 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 331678000494 putative active site [active] 331678000495 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678000496 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 331678000497 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678000498 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 331678000499 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678000500 active site 331678000501 metal binding site [ion binding]; metal-binding site 331678000502 peptide chain release factor 2; Validated; Region: prfB; PRK00578 331678000503 RF-1 domain; Region: RF-1; cl02875 331678000504 RF-1 domain; Region: RF-1; cl02875 331678000505 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 331678000506 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 331678000507 active site 331678000508 homodimer interface [polypeptide binding]; other site 331678000509 catalytic site [active] 331678000510 acceptor binding site [chemical binding]; other site 331678000511 trehalose synthase; Region: treS_nterm; TIGR02456 331678000512 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 331678000513 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 331678000514 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 331678000515 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 331678000516 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331678000517 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 331678000518 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678000519 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 331678000520 Predicted esterase [General function prediction only]; Region: COG0400 331678000521 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678000522 active site 331678000523 NTP binding site [chemical binding]; other site 331678000524 metal binding triad [ion binding]; metal-binding site 331678000525 antibiotic binding site [chemical binding]; other site 331678000526 Protein of unknown function DUF86; Region: DUF86; cl01031 331678000527 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 331678000528 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 331678000529 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 331678000530 classical (c) SDRs; Region: SDR_c; cd05233 331678000531 NAD(P) binding site [chemical binding]; other site 331678000532 active site 331678000533 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 331678000534 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 331678000535 trmE is a tRNA modification GTPase; Region: trmE; cd04164 331678000536 G1 box; other site 331678000537 GTP/Mg2+ binding site [chemical binding]; other site 331678000538 Switch I region; other site 331678000539 G2 box; other site 331678000540 Switch II region; other site 331678000541 G3 box; other site 331678000542 G4 box; other site 331678000543 G5 box; other site 331678000544 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 331678000545 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 331678000546 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 331678000547 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 331678000548 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678000549 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678000550 P loop; other site 331678000551 Nucleotide binding site [chemical binding]; other site 331678000552 DTAP/Switch II; other site 331678000553 Switch I; other site 331678000554 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678000555 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 331678000556 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000557 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678000558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000559 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 331678000560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000563 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000564 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000565 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000566 EamA-like transporter family; Region: EamA; cl01037 331678000567 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678000568 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678000569 NAD(P) binding site [chemical binding]; other site 331678000570 putative active site [active] 331678000571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000572 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 331678000573 FeS/SAM binding site; other site 331678000574 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000576 S-adenosylmethionine binding site [chemical binding]; other site 331678000577 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 331678000578 Sodium:solute symporter family; Region: SSF; cl00456 331678000579 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 331678000580 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 331678000581 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 331678000582 Substrate binding site; other site 331678000583 metal-binding site 331678000584 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 331678000585 N-terminal domain interface [polypeptide binding]; other site 331678000586 Phosphotransferase enzyme family; Region: APH; pfam01636 331678000587 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331678000588 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678000589 B12 binding site [chemical binding]; other site 331678000590 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678000591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000592 FeS/SAM binding site; other site 331678000593 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 331678000594 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 331678000595 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 331678000596 classical (c) SDRs; Region: SDR_c; cd05233 331678000597 NAD(P) binding site [chemical binding]; other site 331678000598 active site 331678000599 Phospholipid methyltransferase; Region: PEMT; cl00763 331678000600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678000601 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 331678000602 putative homotetramer interface [polypeptide binding]; other site 331678000603 putative homodimer interface [polypeptide binding]; other site 331678000604 putative allosteric switch controlling residues; other site 331678000605 putative metal binding site [ion binding]; other site 331678000606 putative homodimer-homodimer interface [polypeptide binding]; other site 331678000607 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 331678000608 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678000609 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678000610 Protein export membrane protein; Region: SecD_SecF; cl14618 331678000611 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 331678000612 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 331678000613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331678000614 FOG: CBS domain [General function prediction only]; Region: COG0517 331678000615 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 331678000616 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 331678000617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000618 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678000619 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 331678000620 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 331678000621 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678000622 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 331678000623 Cysteine-rich domain; Region: CCG; pfam02754 331678000624 Cysteine-rich domain; Region: CCG; pfam02754 331678000625 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 331678000626 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 331678000627 substrate binding site [chemical binding]; other site 331678000628 active site 331678000629 Ion transport protein; Region: Ion_trans; pfam00520 331678000630 Ion channel; Region: Ion_trans_2; cl11596 331678000631 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678000632 Ligand Binding Site [chemical binding]; other site 331678000633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678000634 Ligand Binding Site [chemical binding]; other site 331678000635 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 331678000636 dimer interface [polypeptide binding]; other site 331678000637 active site 331678000638 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 331678000639 homopentamer interface [polypeptide binding]; other site 331678000640 active site 331678000641 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331678000642 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 331678000643 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331678000644 putative acyl-acceptor binding pocket; other site 331678000645 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 331678000646 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 331678000647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000648 catalytic residue [active] 331678000649 homoserine kinase; Provisional; Region: PRK01212 331678000650 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 331678000651 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 331678000652 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 331678000653 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 331678000654 beta subunit interaction interface [polypeptide binding]; other site 331678000655 Walker A motif; other site 331678000656 ATP binding site [chemical binding]; other site 331678000657 Walker B motif; other site 331678000658 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331678000659 ATP synthase; Region: ATP-synt; cl00365 331678000660 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 331678000661 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 331678000662 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 331678000663 putative catalytic residues [active] 331678000664 putative nucleotide binding site [chemical binding]; other site 331678000665 putative aspartate binding site [chemical binding]; other site 331678000666 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 331678000667 dimer interface [polypeptide binding]; other site 331678000668 putative threonine allosteric regulatory site; other site 331678000669 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 331678000670 putative threonine allosteric regulatory site; other site 331678000671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000672 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 331678000673 competence damage-inducible protein A; Provisional; Region: PRK00549 331678000674 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 331678000675 putative MPT binding site; other site 331678000676 Competence-damaged protein; Region: CinA; cl00666 331678000677 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 331678000678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678000679 ATP binding site [chemical binding]; other site 331678000680 Mg2+ binding site [ion binding]; other site 331678000681 G-X-G motif; other site 331678000682 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 331678000683 ATP binding site [chemical binding]; other site 331678000684 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 331678000685 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 331678000686 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 331678000687 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 331678000688 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 331678000689 hypothetical protein; Provisional; Region: PRK13795 331678000690 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 331678000691 Ligand binding site; other site 331678000692 Putative Catalytic site; other site 331678000693 DXD motif; other site 331678000694 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 331678000695 elongation factor G; Reviewed; Region: PRK12740 331678000696 G1 box; other site 331678000697 putative GEF interaction site [polypeptide binding]; other site 331678000698 GTP/Mg2+ binding site [chemical binding]; other site 331678000699 Switch I region; other site 331678000700 G2 box; other site 331678000701 G3 box; other site 331678000702 Switch II region; other site 331678000703 G4 box; other site 331678000704 G5 box; other site 331678000705 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331678000706 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331678000707 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331678000708 enolase; Provisional; Region: eno; PRK00077 331678000709 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 331678000710 dimer interface [polypeptide binding]; other site 331678000711 metal binding site [ion binding]; metal-binding site 331678000712 substrate binding pocket [chemical binding]; other site 331678000713 Septum formation initiator; Region: DivIC; cl11433 331678000714 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331678000715 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331678000716 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 331678000717 classical (c) SDRs; Region: SDR_c; cd05233 331678000718 NAD(P) binding site [chemical binding]; other site 331678000719 active site 331678000720 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 331678000721 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 331678000722 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 331678000723 putative homodimer interface [polypeptide binding]; other site 331678000724 KOW motif; Region: KOW; cl00354 331678000725 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 331678000726 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 331678000727 23S rRNA interface [nucleotide binding]; other site 331678000728 L7/L12 interface [polypeptide binding]; other site 331678000729 putative thiostrepton binding site; other site 331678000730 L25 interface [polypeptide binding]; other site 331678000731 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 331678000732 mRNA/rRNA interface [nucleotide binding]; other site 331678000733 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 331678000734 23S rRNA interface [nucleotide binding]; other site 331678000735 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 331678000736 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 331678000737 core dimer interface [polypeptide binding]; other site 331678000738 peripheral dimer interface [polypeptide binding]; other site 331678000739 L10 interface [polypeptide binding]; other site 331678000740 L11 interface [polypeptide binding]; other site 331678000741 putative EF-Tu interaction site [polypeptide binding]; other site 331678000742 putative EF-G interaction site [polypeptide binding]; other site 331678000743 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 331678000744 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 331678000745 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331678000746 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 331678000747 RPB11 interaction site [polypeptide binding]; other site 331678000748 RPB12 interaction site [polypeptide binding]; other site 331678000749 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331678000750 RPB3 interaction site [polypeptide binding]; other site 331678000751 RPB1 interaction site [polypeptide binding]; other site 331678000752 RPB11 interaction site [polypeptide binding]; other site 331678000753 RPB10 interaction site [polypeptide binding]; other site 331678000754 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 331678000755 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 331678000756 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 331678000757 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 331678000758 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 331678000759 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 331678000760 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 331678000761 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 331678000762 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 331678000763 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 331678000764 DNA binding site [nucleotide binding] 331678000765 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 331678000766 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 331678000767 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331678000768 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678000769 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 331678000770 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 331678000771 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331678000772 carboxyltransferase (CT) interaction site; other site 331678000773 biotinylation site [posttranslational modification]; other site 331678000774 elongation factor P; Validated; Region: PRK00529 331678000775 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 331678000776 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 331678000777 RNA binding site [nucleotide binding]; other site 331678000778 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 331678000779 RNA binding site [nucleotide binding]; other site 331678000780 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331678000781 IHF - DNA interface [nucleotide binding]; other site 331678000782 IHF dimer interface [polypeptide binding]; other site 331678000783 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 331678000784 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 331678000785 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 331678000786 TPP-binding site [chemical binding]; other site 331678000787 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 331678000788 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 331678000789 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331678000790 dimer interface [polypeptide binding]; other site 331678000791 PYR/PP interface [polypeptide binding]; other site 331678000792 TPP binding site [chemical binding]; other site 331678000793 substrate binding site [chemical binding]; other site 331678000794 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 331678000795 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 331678000796 motif 1; other site 331678000797 active site 331678000798 motif 2; other site 331678000799 motif 3; other site 331678000800 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 331678000801 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 331678000802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000803 NAD(P) binding site [chemical binding]; other site 331678000804 active site 331678000805 HsdM N-terminal domain; Region: HsdM_N; pfam12161 331678000806 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 331678000807 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000808 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678000809 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000810 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 331678000811 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 331678000812 5' RNA guide strand anchoring site; other site 331678000813 active site 331678000814 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 331678000815 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678000816 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 331678000817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678000818 ATP binding site [chemical binding]; other site 331678000819 putative Mg++ binding site [ion binding]; other site 331678000820 Protein of unknown function DUF45; Region: DUF45; cl00636 331678000821 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 331678000822 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 331678000823 phosphoserine phosphatase SerB; Region: serB; TIGR00338 331678000824 viral phosphatase superfamily protein; Provisional; Region: PHA03398 331678000825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678000826 motif II; other site 331678000827 GMP synthase; Reviewed; Region: guaA; PRK00074 331678000828 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 331678000829 AMP/PPi binding site [chemical binding]; other site 331678000830 candidate oxyanion hole; other site 331678000831 catalytic triad [active] 331678000832 potential glutamine specificity residues [chemical binding]; other site 331678000833 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 331678000834 ATP Binding subdomain [chemical binding]; other site 331678000835 Ligand Binding sites [chemical binding]; other site 331678000836 Dimerization subdomain; other site 331678000837 Transglycosylase; Region: Transgly; cl07896 331678000838 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 331678000839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 331678000840 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678000841 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 331678000842 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 331678000843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000844 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 331678000845 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 331678000846 Cytochrome c; Region: Cytochrom_C; cl11414 331678000847 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 331678000848 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678000849 putative NAD(P) binding site [chemical binding]; other site 331678000850 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 331678000851 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 331678000852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000853 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 331678000854 catalytic triad [active] 331678000855 Clp protease ATP binding subunit; Region: clpC; CHL00095 331678000856 Clp amino terminal domain; Region: Clp_N; pfam02861 331678000857 Clp amino terminal domain; Region: Clp_N; pfam02861 331678000858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000859 Walker A motif; other site 331678000860 ATP binding site [chemical binding]; other site 331678000861 Walker B motif; other site 331678000862 arginine finger; other site 331678000863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000864 Walker A motif; other site 331678000865 ATP binding site [chemical binding]; other site 331678000866 Walker B motif; other site 331678000867 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 331678000868 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 331678000869 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 331678000870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000871 catalytic residue [active] 331678000872 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331678000873 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 331678000874 putative active site [active] 331678000875 thiamine monophosphate kinase; Provisional; Region: PRK05731 331678000876 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 331678000877 ATP binding site [chemical binding]; other site 331678000878 dimerization interface [polypeptide binding]; other site 331678000879 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 331678000880 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 331678000881 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 331678000882 P loop; other site 331678000883 GTP binding site [chemical binding]; other site 331678000884 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 331678000885 GIY-YIG motif/motif A; other site 331678000886 putative active site [active] 331678000887 putative metal binding site [ion binding]; other site 331678000888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000889 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 331678000890 SurA N-terminal domain; Region: SurA_N_3; cl07813 331678000891 PPIC-type PPIASE domain; Region: Rotamase; cl08278 331678000892 PPIC-type PPIASE domain; Region: Rotamase; cl08278 331678000893 PPIC-type PPIASE domain; Region: Rotamase; cl08278 331678000894 periplasmic folding chaperone; Provisional; Region: PRK10788 331678000895 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 331678000896 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 331678000897 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 331678000898 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 331678000899 replicative DNA helicase; Region: DnaB; TIGR00665 331678000900 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 331678000901 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 331678000902 Walker A motif; other site 331678000903 ATP binding site [chemical binding]; other site 331678000904 Walker B motif; other site 331678000905 DNA binding loops [nucleotide binding] 331678000906 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 331678000907 Fe-S cluster binding site [ion binding]; other site 331678000908 active site 331678000909 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 331678000910 Flavoprotein; Region: Flavoprotein; cl08021 331678000911 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 331678000912 Family of unknown function (DUF490); Region: DUF490; pfam04357 331678000913 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678000914 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 331678000915 active site 331678000916 nucleotide binding site [chemical binding]; other site 331678000917 HIGH motif; other site 331678000918 KMSKS motif; other site 331678000919 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 331678000920 putative acyl-acceptor binding pocket; other site 331678000921 Chain length determinant protein; Region: Wzz; cl15801 331678000922 Chain length determinant protein; Region: Wzz; cl15801 331678000923 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 331678000924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000925 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 331678000926 NAD(P) binding site [chemical binding]; other site 331678000927 homodimer interface [polypeptide binding]; other site 331678000928 substrate binding site [chemical binding]; other site 331678000929 active site 331678000930 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678000931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678000932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678000933 Walker A/P-loop; other site 331678000934 ATP binding site [chemical binding]; other site 331678000935 Q-loop/lid; other site 331678000936 ABC transporter signature motif; other site 331678000937 Walker B; other site 331678000938 D-loop; other site 331678000939 H-loop/switch region; other site 331678000940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678000941 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 331678000942 putative ADP-binding pocket [chemical binding]; other site 331678000943 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 331678000944 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 331678000945 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678000946 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 331678000947 putative active site [active] 331678000948 putative metal binding site [ion binding]; other site 331678000949 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678000950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678000951 active site 331678000952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678000953 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 331678000954 putative ADP-binding pocket [chemical binding]; other site 331678000955 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 331678000956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678000957 putative ADP-binding pocket [chemical binding]; other site 331678000958 Bacterial sugar transferase; Region: Bac_transf; cl00939 331678000959 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 331678000960 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678000961 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678000962 extended (e) SDRs; Region: SDR_e; cd08946 331678000963 NAD(P) binding site [chemical binding]; other site 331678000964 active site 331678000965 substrate binding site [chemical binding]; other site 331678000966 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 331678000967 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 331678000968 inhibitor-cofactor binding pocket; inhibition site 331678000969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000970 catalytic residue [active] 331678000971 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678000972 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 331678000973 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 331678000974 Walker A/P-loop; other site 331678000975 ATP binding site [chemical binding]; other site 331678000976 Q-loop/lid; other site 331678000977 ABC transporter signature motif; other site 331678000978 Walker B; other site 331678000979 D-loop; other site 331678000980 H-loop/switch region; other site 331678000981 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 331678000982 Substrate binding site; other site 331678000983 metal-binding site 331678000984 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 331678000985 putative metal binding site; other site 331678000986 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331678000987 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331678000988 putative active site [active] 331678000989 O-Antigen ligase; Region: Wzy_C; cl04850 331678000990 CAAX protease self-immunity; Region: Abi; cl00558 331678000991 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 331678000992 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 331678000993 active site 331678000994 phosphorylation site [posttranslational modification] 331678000995 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 331678000996 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 331678000997 dimer interface [polypeptide binding]; other site 331678000998 motif 1; other site 331678000999 active site 331678001000 motif 2; other site 331678001001 motif 3; other site 331678001002 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 331678001003 anticodon binding site; other site 331678001004 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 331678001005 catalytic residues [active] 331678001006 ribosome maturation protein RimP; Reviewed; Region: PRK00092 331678001007 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 331678001008 NusA N-terminal domain; Region: NusA_N; pfam08529 331678001009 transcription termination factor NusA; Region: NusA; TIGR01953 331678001010 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678001011 RNA binding site [nucleotide binding]; other site 331678001012 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 331678001013 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 331678001014 G-X-X-G motif; other site 331678001015 translation initiation factor IF-2; Validated; Region: infB; PRK05306 331678001016 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 331678001017 translation initiation factor IF-2; Region: IF-2; TIGR00487 331678001018 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 331678001019 G1 box; other site 331678001020 putative GEF interaction site [polypeptide binding]; other site 331678001021 GTP/Mg2+ binding site [chemical binding]; other site 331678001022 Switch I region; other site 331678001023 G2 box; other site 331678001024 G3 box; other site 331678001025 Switch II region; other site 331678001026 G4 box; other site 331678001027 G5 box; other site 331678001028 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 331678001029 Translation-initiation factor 2; Region: IF-2; pfam11987 331678001030 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 331678001031 Ribosome-binding factor A; Region: RBFA; cl00542 331678001032 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 331678001033 RNA binding site [nucleotide binding]; other site 331678001034 active site 331678001035 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 331678001036 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 331678001037 active site 331678001038 Riboflavin kinase; Region: Flavokinase; cl03312 331678001039 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 331678001040 16S/18S rRNA binding site [nucleotide binding]; other site 331678001041 S13e-L30e interaction site [polypeptide binding]; other site 331678001042 25S rRNA binding site [nucleotide binding]; other site 331678001043 hypothetical protein; Provisional; Region: PRK11820 331678001044 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 331678001045 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 331678001046 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 331678001047 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 331678001048 catalytic site [active] 331678001049 G-X2-G-X-G-K; other site 331678001050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331678001051 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331678001052 active site 331678001053 metal binding site [ion binding]; metal-binding site 331678001054 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 331678001055 Substrate binding site; other site 331678001056 Mg++ binding site; other site 331678001057 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 331678001058 tetramerization interface [polypeptide binding]; other site 331678001059 active site 331678001060 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 331678001061 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 331678001062 periplasmic chaperone; Provisional; Region: PRK10780 331678001063 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 331678001064 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331678001065 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331678001066 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331678001067 substrate binding pocket [chemical binding]; other site 331678001068 chain length determination region; other site 331678001069 substrate-Mg2+ binding site; other site 331678001070 catalytic residues [active] 331678001071 aspartate-rich region 1; other site 331678001072 active site lid residues [active] 331678001073 aspartate-rich region 2; other site 331678001074 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 331678001075 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 331678001076 homotetramer interface [polypeptide binding]; other site 331678001077 FMN binding site [chemical binding]; other site 331678001078 homodimer contacts [polypeptide binding]; other site 331678001079 putative active site [active] 331678001080 putative substrate binding site [chemical binding]; other site 331678001081 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678001082 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678001083 FtsX-like permease family; Region: FtsX; cl15850 331678001084 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678001085 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678001086 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 331678001087 Walker A/P-loop; other site 331678001088 ATP binding site [chemical binding]; other site 331678001089 Q-loop/lid; other site 331678001090 ABC transporter signature motif; other site 331678001091 Walker B; other site 331678001092 D-loop; other site 331678001093 H-loop/switch region; other site 331678001094 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 331678001095 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 331678001096 active site 331678001097 substrate binding site [chemical binding]; other site 331678001098 metal binding site [ion binding]; metal-binding site 331678001099 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 331678001100 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 331678001101 RuvA N terminal domain; Region: RuvA_N; pfam01330 331678001102 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 331678001103 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 331678001104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678001105 transcription termination factor Rho; Provisional; Region: rho; PRK09376 331678001106 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 331678001107 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 331678001108 RNA binding site [nucleotide binding]; other site 331678001109 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 331678001110 multimer interface [polypeptide binding]; other site 331678001111 Walker A motif; other site 331678001112 ATP binding site [chemical binding]; other site 331678001113 Walker B motif; other site 331678001114 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 331678001115 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 331678001116 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 331678001117 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 331678001118 Ligand binding site [chemical binding]; other site 331678001119 Electron transfer flavoprotein domain; Region: ETF; pfam01012 331678001120 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 331678001121 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 331678001122 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 331678001123 Bifunctional nuclease; Region: DNase-RNase; cl00553 331678001124 UvrB/uvrC motif; Region: UVR; pfam02151 331678001125 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678001126 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678001127 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678001128 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 331678001129 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 331678001130 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 331678001131 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 331678001132 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 331678001133 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 331678001134 Surface antigen; Region: Bac_surface_Ag; cl03097 331678001135 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 331678001136 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 331678001137 catalytic residue [active] 331678001138 putative FPP diphosphate binding site; other site 331678001139 putative FPP binding hydrophobic cleft; other site 331678001140 dimer interface [polypeptide binding]; other site 331678001141 putative IPP diphosphate binding site; other site 331678001142 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 331678001143 Amidase; Region: Amidase; cl11426 331678001144 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 331678001145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001146 CoA-ligase; Region: Ligase_CoA; cl02894 331678001147 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 331678001148 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 331678001149 putative active site [active] 331678001150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 331678001151 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 331678001152 MatE; Region: MatE; cl10513 331678001153 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 331678001154 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 331678001155 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 331678001156 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678001157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678001158 DNA binding residues [nucleotide binding] 331678001159 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678001160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001161 S-adenosylmethionine binding site [chemical binding]; other site 331678001162 Protein of unknown function, DUF393; Region: DUF393; cl01136 331678001163 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 331678001164 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 331678001165 active site 331678001166 substrate binding site [chemical binding]; other site 331678001167 metal binding site [ion binding]; metal-binding site 331678001168 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 331678001169 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 331678001170 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 331678001171 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331678001172 TOBE domain; Region: TOBE_2; cl01440 331678001173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678001174 dimer interface [polypeptide binding]; other site 331678001175 conserved gate region; other site 331678001176 putative PBP binding loops; other site 331678001177 ABC-ATPase subunit interface; other site 331678001178 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 331678001179 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001180 Walker A/P-loop; other site 331678001181 ATP binding site [chemical binding]; other site 331678001182 Q-loop/lid; other site 331678001183 ABC transporter signature motif; other site 331678001184 Walker B; other site 331678001185 D-loop; other site 331678001186 H-loop/switch region; other site 331678001187 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 331678001188 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678001189 catalytic loop [active] 331678001190 iron binding site [ion binding]; other site 331678001191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001193 LytB protein; Region: LYTB; cl00507 331678001194 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 331678001195 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 331678001196 pteridine reductase; Provisional; Region: PRK09135 331678001197 classical (c) SDRs; Region: SDR_c; cd05233 331678001198 NAD(P) binding site [chemical binding]; other site 331678001199 active site 331678001200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 331678001201 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 331678001202 Walker A/P-loop; other site 331678001203 ATP binding site [chemical binding]; other site 331678001204 Q-loop/lid; other site 331678001205 ABC transporter signature motif; other site 331678001206 Walker B; other site 331678001207 D-loop; other site 331678001208 H-loop/switch region; other site 331678001209 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 331678001210 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 331678001211 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 331678001212 nucleotide binding pocket [chemical binding]; other site 331678001213 K-X-D-G motif; other site 331678001214 catalytic site [active] 331678001215 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 331678001216 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 331678001217 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 331678001218 Dimer interface [polypeptide binding]; other site 331678001219 BRCT sequence motif; other site 331678001220 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331678001221 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 331678001222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001223 S-adenosylmethionine binding site [chemical binding]; other site 331678001224 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 331678001225 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678001226 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678001227 Membrane transport protein; Region: Mem_trans; cl09117 331678001228 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 331678001229 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 331678001230 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 331678001231 putative dimer interface [polypeptide binding]; other site 331678001232 [2Fe-2S] cluster binding site [ion binding]; other site 331678001233 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 331678001234 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 331678001235 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 331678001236 SLBB domain; Region: SLBB; pfam10531 331678001237 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 331678001238 4Fe-4S binding domain; Region: Fer4; cl02805 331678001239 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 331678001240 4Fe-4S binding domain; Region: Fer4; cl02805 331678001241 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 331678001242 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 331678001243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678001245 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 331678001246 4Fe-4S binding domain; Region: Fer4; cl02805 331678001247 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 331678001248 molybdopterin cofactor binding site; other site 331678001249 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 331678001250 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 331678001251 putative active site [active] 331678001252 oxyanion strand; other site 331678001253 catalytic triad [active] 331678001254 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 331678001255 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 331678001256 catalytic residues [active] 331678001257 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 331678001258 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 331678001259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678001260 RNA binding surface [nucleotide binding]; other site 331678001261 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 331678001262 active site 331678001263 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 331678001264 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678001265 active site 331678001266 substrate binding site [chemical binding]; other site 331678001267 catalytic site [active] 331678001268 Protein of unknown function (DUF419); Region: DUF419; cl15265 331678001269 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331678001270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678001271 motif II; other site 331678001272 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 331678001273 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 331678001274 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 331678001275 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 331678001276 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 331678001277 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 331678001278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678001279 aminodeoxychorismate synthase; Provisional; Region: PRK07508 331678001280 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331678001281 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 331678001282 homodimer interface [polypeptide binding]; other site 331678001283 substrate-cofactor binding pocket; other site 331678001284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001285 catalytic residue [active] 331678001286 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 331678001287 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331678001288 minor groove reading motif; other site 331678001289 helix-hairpin-helix signature motif; other site 331678001290 substrate binding pocket [chemical binding]; other site 331678001291 active site 331678001292 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 331678001293 Transposase domain (DUF772); Region: DUF772; cl15789 331678001294 Transposase domain (DUF772); Region: DUF772; cl15789 331678001295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678001296 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 331678001297 active site 331678001298 metal binding site [ion binding]; metal-binding site 331678001299 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 331678001300 putative RNA binding site [nucleotide binding]; other site 331678001301 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331678001302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678001303 motif II; other site 331678001304 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331678001305 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 331678001306 Walker A/P-loop; other site 331678001307 ATP binding site [chemical binding]; other site 331678001308 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 331678001309 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 331678001310 ABC transporter signature motif; other site 331678001311 Walker B; other site 331678001312 D-loop; other site 331678001313 H-loop/switch region; other site 331678001314 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 331678001315 dihydropteroate synthase; Region: DHPS; TIGR01496 331678001316 substrate binding pocket [chemical binding]; other site 331678001317 dimer interface [polypeptide binding]; other site 331678001318 inhibitor binding site; inhibition site 331678001319 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 331678001320 active site 331678001321 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331678001322 putative substrate binding region [chemical binding]; other site 331678001323 Haem-binding domain; Region: Haem_bd; pfam14376 331678001324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001325 Rrf2 family protein; Region: rrf2_super; TIGR00738 331678001326 Helix-turn-helix domains; Region: HTH; cl00088 331678001327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001328 TPR motif; other site 331678001329 TPR repeat; Region: TPR_11; pfam13414 331678001330 binding surface 331678001331 hybrid cluster protein; Provisional; Region: PRK05290 331678001332 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678001333 ACS interaction site; other site 331678001334 CODH interaction site; other site 331678001335 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 331678001336 hybrid metal cluster; other site 331678001337 Predicted permeases [General function prediction only]; Region: COG0701 331678001338 Predicted permease; Region: DUF318; pfam03773 331678001339 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 331678001340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678001341 putative DNA binding site [nucleotide binding]; other site 331678001342 dimerization interface [polypeptide binding]; other site 331678001343 putative Zn2+ binding site [ion binding]; other site 331678001344 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 331678001345 ZIP Zinc transporter; Region: Zip; pfam02535 331678001346 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 331678001347 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678001348 dimer interface [polypeptide binding]; other site 331678001349 active site 331678001350 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678001351 YibE/F-like protein; Region: YibE_F; cl02259 331678001352 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 331678001353 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 331678001354 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 331678001355 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678001356 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678001357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678001358 FeS/SAM binding site; other site 331678001359 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 331678001360 A new structural DNA glycosylase; Region: AlkD_like; cd06561 331678001361 active site 331678001362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678001363 dimerization interface [polypeptide binding]; other site 331678001364 putative DNA binding site [nucleotide binding]; other site 331678001365 putative Zn2+ binding site [ion binding]; other site 331678001366 Predicted permeases [General function prediction only]; Region: COG0701 331678001367 Predicted permease; Region: DUF318; pfam03773 331678001368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 331678001369 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 331678001370 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 331678001371 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678001372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678001373 motif II; other site 331678001374 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 331678001375 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 331678001376 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 331678001377 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 331678001378 pyruvate phosphate dikinase; Provisional; Region: PRK09279 331678001379 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 331678001380 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 331678001381 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 331678001382 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 331678001383 TM-ABC transporter signature motif; other site 331678001384 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 331678001385 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 331678001386 conserved cys residue [active] 331678001387 NAD-dependent deacetylase; Provisional; Region: PRK00481 331678001388 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 331678001389 NAD+ binding site [chemical binding]; other site 331678001390 substrate binding site [chemical binding]; other site 331678001391 Zn binding site [ion binding]; other site 331678001392 Phospholipid methyltransferase; Region: PEMT; cl00763 331678001393 Isochorismatase family; Region: Isochorismatase; pfam00857 331678001394 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 331678001395 catalytic triad [active] 331678001396 dimer interface [polypeptide binding]; other site 331678001397 conserved cis-peptide bond; other site 331678001398 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 331678001399 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 331678001400 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 331678001401 putative acyl-acceptor binding pocket; other site 331678001402 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 331678001403 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 331678001404 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678001405 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 331678001406 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 331678001407 MPN+ (JAMM) motif; other site 331678001408 Zinc-binding site [ion binding]; other site 331678001409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331678001410 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 331678001411 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678001412 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 331678001413 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 331678001414 active site 331678001415 ribulose/triose binding site [chemical binding]; other site 331678001416 phosphate binding site [ion binding]; other site 331678001417 substrate (anthranilate) binding pocket [chemical binding]; other site 331678001418 product (indole) binding pocket [chemical binding]; other site 331678001419 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 331678001420 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 331678001421 substrate binding site [chemical binding]; other site 331678001422 hexamer interface [polypeptide binding]; other site 331678001423 metal binding site [ion binding]; metal-binding site 331678001424 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 331678001425 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 331678001426 Surface antigen; Region: Bac_surface_Ag; cl03097 331678001427 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 331678001428 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678001429 DNA polymerase I; Provisional; Region: PRK05755 331678001430 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 331678001431 active site 331678001432 metal binding site 1 [ion binding]; metal-binding site 331678001433 putative 5' ssDNA interaction site; other site 331678001434 metal binding site 3; metal-binding site 331678001435 metal binding site 2 [ion binding]; metal-binding site 331678001436 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 331678001437 putative DNA binding site [nucleotide binding]; other site 331678001438 putative metal binding site [ion binding]; other site 331678001439 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 331678001440 active site 331678001441 catalytic site [active] 331678001442 substrate binding site [chemical binding]; other site 331678001443 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 331678001444 active site 331678001445 DNA binding site [nucleotide binding] 331678001446 catalytic site [active] 331678001447 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 331678001448 Prephenate dehydratase; Region: PDT; pfam00800 331678001449 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 331678001450 putative L-Phe binding site [chemical binding]; other site 331678001451 Transcriptional regulator; Region: Transcrip_reg; cl00361 331678001452 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 331678001453 active site 331678001454 putative DNA-binding cleft [nucleotide binding]; other site 331678001455 dimer interface [polypeptide binding]; other site 331678001456 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 331678001457 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 331678001458 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 331678001459 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 331678001460 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 331678001461 active site 331678001462 dimerization interface [polypeptide binding]; other site 331678001463 TspO/MBR family; Region: TspO_MBR; cl01379 331678001464 acetyl-CoA synthetase; Provisional; Region: PRK00174 331678001465 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 331678001466 AMP-binding enzyme; Region: AMP-binding; cl15778 331678001467 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331678001468 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 331678001469 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 331678001470 HIGH motif; other site 331678001471 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331678001472 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 331678001473 active site 331678001474 KMSKS motif; other site 331678001475 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 331678001476 tRNA binding surface [nucleotide binding]; other site 331678001477 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 331678001478 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 331678001479 RNase E interface [polypeptide binding]; other site 331678001480 trimer interface [polypeptide binding]; other site 331678001481 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 331678001482 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 331678001483 RNase E interface [polypeptide binding]; other site 331678001484 trimer interface [polypeptide binding]; other site 331678001485 active site 331678001486 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 331678001487 putative nucleic acid binding region [nucleotide binding]; other site 331678001488 G-X-X-G motif; other site 331678001489 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 331678001490 RNA binding site [nucleotide binding]; other site 331678001491 domain interface; other site 331678001492 pantoate--beta-alanine ligase; Region: panC; TIGR00018 331678001493 Pantoate-beta-alanine ligase; Region: PanC; cd00560 331678001494 active site 331678001495 ATP-binding site [chemical binding]; other site 331678001496 pantoate-binding site; other site 331678001497 HXXH motif; other site 331678001498 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 331678001499 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 331678001500 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331678001501 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 331678001502 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678001503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678001504 non-specific DNA binding site [nucleotide binding]; other site 331678001505 salt bridge; other site 331678001506 sequence-specific DNA binding site [nucleotide binding]; other site 331678001507 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 331678001508 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 331678001509 Walker A/P-loop; other site 331678001510 ATP binding site [chemical binding]; other site 331678001511 Q-loop/lid; other site 331678001512 ABC transporter signature motif; other site 331678001513 Walker B; other site 331678001514 D-loop; other site 331678001515 H-loop/switch region; other site 331678001516 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331678001517 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 331678001518 tandem repeat interface [polypeptide binding]; other site 331678001519 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 331678001520 oligomer interface [polypeptide binding]; other site 331678001521 active site residues [active] 331678001522 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 331678001523 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 331678001524 tandem repeat interface [polypeptide binding]; other site 331678001525 oligomer interface [polypeptide binding]; other site 331678001526 active site residues [active] 331678001527 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 331678001528 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 331678001529 active site 331678001530 cosubstrate binding site; other site 331678001531 substrate binding site [chemical binding]; other site 331678001532 catalytic site [active] 331678001533 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 331678001534 Membrane transport protein; Region: Mem_trans; cl09117 331678001535 Low molecular weight phosphatase family; Region: LMWPc; cl00105 331678001536 active site 331678001537 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678001538 dimerization interface [polypeptide binding]; other site 331678001539 putative DNA binding site [nucleotide binding]; other site 331678001540 putative Zn2+ binding site [ion binding]; other site 331678001541 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 331678001542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678001543 non-specific DNA binding site [nucleotide binding]; other site 331678001544 salt bridge; other site 331678001545 sequence-specific DNA binding site [nucleotide binding]; other site 331678001546 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678001547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678001548 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 331678001549 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 331678001550 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 331678001551 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 331678001552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001553 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 331678001554 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331678001555 DNA binding site [nucleotide binding] 331678001556 Int/Topo IB signature motif; other site 331678001557 active site 331678001558 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 331678001559 30S subunit binding site; other site 331678001560 HPr kinase/phosphorylase; Provisional; Region: PRK05428 331678001561 DRTGG domain; Region: DRTGG; cl12147 331678001562 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 331678001563 Hpr binding site; other site 331678001564 active site 331678001565 homohexamer subunit interaction site [polypeptide binding]; other site 331678001566 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331678001567 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 331678001568 peptide binding site [polypeptide binding]; other site 331678001569 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331678001570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678001571 dimer interface [polypeptide binding]; other site 331678001572 conserved gate region; other site 331678001573 putative PBP binding loops; other site 331678001574 ABC-ATPase subunit interface; other site 331678001575 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 331678001576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678001577 Walker A motif; other site 331678001578 ATP binding site [chemical binding]; other site 331678001579 Walker B motif; other site 331678001580 arginine finger; other site 331678001581 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 331678001582 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 331678001583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001584 binding surface 331678001585 TPR motif; other site 331678001586 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 331678001587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001588 TPR motif; other site 331678001589 binding surface 331678001590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001591 TPR motif; other site 331678001592 binding surface 331678001593 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 331678001594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001595 TPR motif; other site 331678001596 binding surface 331678001597 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 331678001598 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331678001599 dimer interface [polypeptide binding]; other site 331678001600 PYR/PP interface [polypeptide binding]; other site 331678001601 TPP binding site [chemical binding]; other site 331678001602 substrate binding site [chemical binding]; other site 331678001603 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 331678001604 Domain of unknown function; Region: EKR; cl11037 331678001605 4Fe-4S binding domain; Region: Fer4; cl02805 331678001606 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 331678001607 TPP-binding site [chemical binding]; other site 331678001608 dimer interface [polypeptide binding]; other site 331678001609 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 331678001610 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 331678001611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 331678001612 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 331678001613 lipoyl attachment site [posttranslational modification]; other site 331678001614 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 331678001615 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 331678001616 tetramer interface [polypeptide binding]; other site 331678001617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001618 catalytic residue [active] 331678001619 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 331678001620 dihydrodipicolinate synthase; Region: dapA; TIGR00674 331678001621 dimer interface [polypeptide binding]; other site 331678001622 active site 331678001623 catalytic residue [active] 331678001624 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 331678001625 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 331678001626 Walker A/P-loop; other site 331678001627 ATP binding site [chemical binding]; other site 331678001628 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 331678001629 Q-loop/lid; other site 331678001630 ABC transporter signature motif; other site 331678001631 Walker B; other site 331678001632 D-loop; other site 331678001633 H-loop/switch region; other site 331678001634 Lamin Tail Domain; Region: LTD; pfam00932 331678001635 FlgD Ig-like domain; Region: FlgD_ig; cl15790 331678001636 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 331678001637 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 331678001638 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 331678001639 Ligand Binding Site [chemical binding]; other site 331678001640 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 331678001641 RNA/DNA hybrid binding site [nucleotide binding]; other site 331678001642 active site 331678001643 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 331678001644 UbiA prenyltransferase family; Region: UbiA; cl00337 331678001645 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 331678001646 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 331678001647 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 331678001648 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 331678001649 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 331678001650 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 331678001651 active site 331678001652 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 331678001653 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 331678001654 DNA polymerase III subunit delta'; Validated; Region: PRK07132 331678001655 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 331678001656 homodimer interface [polypeptide binding]; other site 331678001657 substrate-cofactor binding pocket; other site 331678001658 catalytic residue [active] 331678001659 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 331678001660 active site 331678001661 ADP/pyrophosphate binding site [chemical binding]; other site 331678001662 dimerization interface [polypeptide binding]; other site 331678001663 allosteric effector site; other site 331678001664 fructose-1,6-bisphosphate binding site; other site 331678001665 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678001666 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678001667 FtsX-like permease family; Region: FtsX; cl15850 331678001668 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 331678001669 homotrimer interaction site [polypeptide binding]; other site 331678001670 zinc binding site [ion binding]; other site 331678001671 CDP-binding sites; other site 331678001672 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 331678001673 Protein of unknown function (DUF805); Region: DUF805; cl01224 331678001674 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 331678001675 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 331678001676 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 331678001677 heterodimer interface [polypeptide binding]; other site 331678001678 active site 331678001679 FMN binding site [chemical binding]; other site 331678001680 homodimer interface [polypeptide binding]; other site 331678001681 substrate binding site [chemical binding]; other site 331678001682 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331678001683 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 331678001684 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 331678001685 putative active site [active] 331678001686 putative metal binding site [ion binding]; other site 331678001687 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331678001688 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 331678001689 Ferritin-like domain; Region: Ferritin; pfam00210 331678001690 ferroxidase diiron center [ion binding]; other site 331678001691 FeoA domain; Region: FeoA; cl00838 331678001692 FeoA domain; Region: FeoA; cl00838 331678001693 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 331678001694 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 331678001695 G1 box; other site 331678001696 GTP/Mg2+ binding site [chemical binding]; other site 331678001697 Switch I region; other site 331678001698 G2 box; other site 331678001699 G3 box; other site 331678001700 Switch II region; other site 331678001701 G4 box; other site 331678001702 G5 box; other site 331678001703 Nucleoside recognition; Region: Gate; cl00486 331678001704 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 331678001705 Nucleoside recognition; Region: Gate; cl00486 331678001706 Helix-turn-helix domains; Region: HTH; cl00088 331678001707 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678001708 iron-sulfur cluster [ion binding]; other site 331678001709 [2Fe-2S] cluster binding site [ion binding]; other site 331678001710 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 331678001711 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 331678001712 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331678001713 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 331678001714 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678001715 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 331678001716 IMP binding site; other site 331678001717 dimer interface [polypeptide binding]; other site 331678001718 interdomain contacts; other site 331678001719 partial ornithine binding site; other site 331678001720 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 331678001721 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 331678001722 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 331678001723 dimerization interface [polypeptide binding]; other site 331678001724 active site 331678001725 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 331678001726 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 331678001727 dimer interface [polypeptide binding]; other site 331678001728 glycine-pyridoxal phosphate binding site [chemical binding]; other site 331678001729 active site 331678001730 folate binding site [chemical binding]; other site 331678001731 DNA primase; Validated; Region: dnaG; PRK05667 331678001732 CHC2 zinc finger; Region: zf-CHC2; cl15369 331678001733 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 331678001734 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 331678001735 active site 331678001736 metal binding site [ion binding]; metal-binding site 331678001737 interdomain interaction site; other site 331678001738 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 331678001739 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 331678001740 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 331678001741 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 331678001742 Gram-negative bacterial tonB protein; Region: TonB; cl10048 331678001743 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 331678001744 acetylornithine aminotransferase; Provisional; Region: PRK02627 331678001745 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331678001746 inhibitor-cofactor binding pocket; inhibition site 331678001747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001748 catalytic residue [active] 331678001749 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331678001750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678001752 Rrf2 family protein; Region: rrf2_super; TIGR00738 331678001753 Helix-turn-helix domains; Region: HTH; cl00088 331678001754 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 331678001755 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331678001756 dimer interface [polypeptide binding]; other site 331678001757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001758 catalytic residue [active] 331678001759 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 331678001760 thiS-thiF/thiG interaction site; other site 331678001761 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 331678001762 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 331678001763 homodimer interface [polypeptide binding]; other site 331678001764 substrate-cofactor binding pocket; other site 331678001765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001766 catalytic residue [active] 331678001767 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 331678001768 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 331678001769 ATP binding site [chemical binding]; other site 331678001770 substrate interface [chemical binding]; other site 331678001771 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 331678001772 MPN+ (JAMM) motif; other site 331678001773 Zinc-binding site [ion binding]; other site 331678001774 DsrE/DsrF-like family; Region: DrsE; cl00672 331678001775 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 331678001776 CPxP motif; other site 331678001777 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678001778 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 331678001779 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 331678001780 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 331678001781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678001782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678001783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678001784 ResB-like family; Region: ResB; pfam05140 331678001785 ResB-like family; Region: ResB; pfam05140 331678001786 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331678001787 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678001788 N-terminal plug; other site 331678001789 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 331678001790 ligand-binding site [chemical binding]; other site 331678001791 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 331678001792 AIR carboxylase; Region: AIRC; cl00310 331678001793 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 331678001794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678001795 FeS/SAM binding site; other site 331678001796 HemN C-terminal domain; Region: HemN_C; pfam06969 331678001797 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 331678001798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001799 active site 331678001800 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 331678001801 putative FMN binding site [chemical binding]; other site 331678001802 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 331678001803 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 331678001804 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 331678001805 ABC transporter; Region: ABC_tran_2; pfam12848 331678001806 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 331678001807 N-formylglutamate amidohydrolase; Region: FGase; cl01522 331678001808 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 331678001809 Transposase domain (DUF772); Region: DUF772; cl15789 331678001810 Transposase domain (DUF772); Region: DUF772; cl15789 331678001811 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 331678001812 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 331678001813 glutathione synthetase; Provisional; Region: PRK12458 331678001814 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678001815 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 331678001816 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678001817 CoA-ligase; Region: Ligase_CoA; cl02894 331678001818 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 331678001819 nucleoside/Zn binding site; other site 331678001820 dimer interface [polypeptide binding]; other site 331678001821 catalytic motif [active] 331678001822 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 331678001823 FMN binding site [chemical binding]; other site 331678001824 substrate binding site [chemical binding]; other site 331678001825 putative catalytic residue [active] 331678001826 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331678001827 catalytic core [active] 331678001828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331678001829 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 331678001830 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 331678001831 active site 331678001832 dimer interface [polypeptide binding]; other site 331678001833 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 331678001834 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331678001835 active site 331678001836 FMN binding site [chemical binding]; other site 331678001837 substrate binding site [chemical binding]; other site 331678001838 3Fe-4S cluster binding site [ion binding]; other site 331678001839 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 331678001840 domain interface; other site 331678001841 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 331678001842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001843 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 331678001844 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 331678001845 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 331678001846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678001847 Walker A motif; other site 331678001848 ATP binding site [chemical binding]; other site 331678001849 Walker B motif; other site 331678001850 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 331678001851 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 331678001852 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331678001853 DNA binding site [nucleotide binding] 331678001854 Int/Topo IB signature motif; other site 331678001855 active site 331678001856 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 331678001857 nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064 331678001858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678001859 FeS/SAM binding site; other site 331678001860 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 331678001861 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678001862 ParA-like protein; Provisional; Region: PHA02518 331678001863 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678001864 P-loop; other site 331678001865 Magnesium ion binding site [ion binding]; other site 331678001866 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 331678001867 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 331678001868 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 331678001869 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 331678001870 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 331678001871 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001872 Walker A motif; other site 331678001873 ATP binding site [chemical binding]; other site 331678001874 Walker B motif; other site 331678001875 Type II/IV secretion system protein; Region: T2SE; pfam00437 331678001876 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 331678001877 ATP binding site [chemical binding]; other site 331678001878 Walker A motif; other site 331678001879 hexamer interface [polypeptide binding]; other site 331678001880 Walker B motif; other site 331678001881 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678001882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678001883 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 331678001884 active site 331678001885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678001886 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331678001887 TM-ABC transporter signature motif; other site 331678001888 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331678001889 TM-ABC transporter signature motif; other site 331678001890 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331678001891 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 331678001892 Walker A/P-loop; other site 331678001893 ATP binding site [chemical binding]; other site 331678001894 Q-loop/lid; other site 331678001895 ABC transporter signature motif; other site 331678001896 Walker B; other site 331678001897 D-loop; other site 331678001898 H-loop/switch region; other site 331678001899 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331678001900 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 331678001901 Walker A/P-loop; other site 331678001902 ATP binding site [chemical binding]; other site 331678001903 Q-loop/lid; other site 331678001904 ABC transporter signature motif; other site 331678001905 Walker B; other site 331678001906 D-loop; other site 331678001907 H-loop/switch region; other site 331678001908 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331678001909 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 331678001910 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678001911 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678001912 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 331678001913 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 331678001914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678001915 ATP binding site [chemical binding]; other site 331678001916 putative Mg++ binding site [ion binding]; other site 331678001917 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 331678001918 HerA helicase [Replication, recombination, and repair]; Region: COG0433 331678001919 Domain of unknown function DUF87; Region: DUF87; pfam01935 331678001920 HerA helicase [Replication, recombination, and repair]; Region: COG0433 331678001921 Transposase domain (DUF772); Region: DUF772; cl15789 331678001922 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678001923 Transposase domain (DUF772); Region: DUF772; cl15789 331678001924 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 331678001925 Predicted transcriptional regulator [Transcription]; Region: COG5340 331678001926 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331678001927 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 331678001928 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331678001929 Fic family protein [Function unknown]; Region: COG3177 331678001930 Fic/DOC family; Region: Fic; cl00960 331678001931 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 331678001932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678001933 ATP binding site [chemical binding]; other site 331678001934 putative Mg++ binding site [ion binding]; other site 331678001935 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001937 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 331678001938 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678001939 Transposase domain (DUF772); Region: DUF772; cl15789 331678001940 Transposase domain (DUF772); Region: DUF772; cl15789 331678001941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678001942 sequence-specific DNA binding site [nucleotide binding]; other site 331678001943 salt bridge; other site 331678001944 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 331678001945 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678001946 oligomeric interface; other site 331678001947 putative active site [active] 331678001948 homodimer interface [polypeptide binding]; other site 331678001949 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331678001950 Phospholipid methyltransferase; Region: PEMT; cl00763 331678001951 2TM domain; Region: 2TM; pfam13239 331678001952 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 331678001953 PemK-like protein; Region: PemK; cl00995 331678001954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 331678001955 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 331678001956 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 331678001957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 331678001958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001959 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 331678001960 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 331678001961 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 331678001962 mobile mystery protein A; Region: mob_myst_A; TIGR02612 331678001963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678001964 mobile mystery protein B; Region: mob_myst_B; TIGR02613 331678001965 Fic/DOC family; Region: Fic; cl00960 331678001966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001967 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678001968 Family description; Region: UvrD_C_2; cl15862 331678001969 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 331678001970 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 331678001971 Virulence protein [General function prediction only]; Region: COG3943 331678001972 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 331678001973 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 331678001974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001975 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 331678001976 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 331678001977 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 331678001978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678001979 ATP binding site [chemical binding]; other site 331678001980 putative Mg++ binding site [ion binding]; other site 331678001981 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 331678001982 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678001983 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 331678001984 HsdM N-terminal domain; Region: HsdM_N; pfam12161 331678001985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678001986 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331678001987 Endoribonuclease XendoU; Region: XendoU; pfam09412 331678001988 Lamin Tail Domain; Region: LTD; pfam00932 331678001989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001990 S-adenosylmethionine binding site [chemical binding]; other site 331678001991 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 331678001992 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 331678001993 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 331678001994 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 331678001995 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678001996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001997 S-adenosylmethionine binding site [chemical binding]; other site 331678001998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 331678001999 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 331678002000 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 331678002001 short chain dehydrogenase; Provisional; Region: PRK06197 331678002002 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 331678002003 putative NAD(P) binding site [chemical binding]; other site 331678002004 active site 331678002005 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 331678002006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002007 Family description; Region: UvrD_C_2; cl15862 331678002008 ribonuclease R; Region: RNase_R; TIGR02063 331678002009 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678002010 RNB domain; Region: RNB; pfam00773 331678002011 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 331678002012 RNA binding site [nucleotide binding]; other site 331678002013 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331678002014 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678002015 photolyase PhrII; Region: phr2; TIGR00591 331678002016 DNA photolyase; Region: DNA_photolyase; pfam00875 331678002017 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 331678002018 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 331678002019 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 331678002020 catalytic triad [active] 331678002021 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002022 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678002023 putative transposase OrfB; Reviewed; Region: PHA02517 331678002024 HTH-like domain; Region: HTH_21; pfam13276 331678002025 Integrase core domain; Region: rve; cl01316 331678002026 Integrase core domain; Region: rve_3; cl15866 331678002027 Helix-turn-helix domains; Region: HTH; cl00088 331678002028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678002029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678002030 catalytic residue [active] 331678002031 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678002032 active site residue [active] 331678002033 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 331678002034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678002035 catalytic residue [active] 331678002036 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 331678002037 hydrolase; Region: PLN02578 331678002038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 331678002039 Rrf2 family protein; Region: rrf2_super; TIGR00738 331678002040 Helix-turn-helix domains; Region: HTH; cl00088 331678002041 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 331678002042 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 331678002043 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 331678002044 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 331678002045 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331678002046 oligomerisation interface [polypeptide binding]; other site 331678002047 mobile loop; other site 331678002048 roof hairpin; other site 331678002049 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 331678002050 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 331678002051 ring oligomerisation interface [polypeptide binding]; other site 331678002052 ATP/Mg binding site [chemical binding]; other site 331678002053 stacking interactions; other site 331678002054 hinge regions; other site 331678002055 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 331678002056 Ligand Binding Site [chemical binding]; other site 331678002057 CAAX protease self-immunity; Region: Abi; cl00558 331678002058 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 331678002059 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 331678002060 substrate binding site [chemical binding]; other site 331678002061 active site 331678002062 catalytic residues [active] 331678002063 heterodimer interface [polypeptide binding]; other site 331678002064 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331678002065 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331678002066 Probable Catalytic site; other site 331678002067 metal-binding site 331678002068 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 331678002069 flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958 331678002070 NADP binding site [chemical binding]; other site 331678002071 substrate binding site [chemical binding]; other site 331678002072 active site 331678002073 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 331678002074 putative hydrophobic ligand binding site [chemical binding]; other site 331678002075 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 331678002076 putative hydrophobic ligand binding site [chemical binding]; other site 331678002077 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 331678002078 putative hydrophobic ligand binding site [chemical binding]; other site 331678002079 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 331678002080 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 331678002081 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 331678002082 aromatic arch; other site 331678002083 DCoH dimer interaction site [polypeptide binding]; other site 331678002084 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 331678002085 DCoH tetramer interaction site [polypeptide binding]; other site 331678002086 substrate binding site [chemical binding]; other site 331678002087 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 331678002088 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002089 Family description; Region: UvrD_C_2; cl15862 331678002090 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 331678002091 Flavoprotein; Region: Flavoprotein; cl08021 331678002092 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 331678002093 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 331678002094 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678002095 DTAP/Switch II; other site 331678002096 Switch I; other site 331678002097 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 331678002098 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 331678002099 NAD binding site [chemical binding]; other site 331678002100 homotetramer interface [polypeptide binding]; other site 331678002101 homodimer interface [polypeptide binding]; other site 331678002102 substrate binding site [chemical binding]; other site 331678002103 active site 331678002104 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 331678002105 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 331678002106 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 331678002107 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 331678002108 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 331678002109 active site 331678002110 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 331678002111 TSCPD domain; Region: TSCPD; cl14834 331678002112 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 331678002113 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678002114 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 331678002115 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002116 Walker A/P-loop; other site 331678002117 ATP binding site [chemical binding]; other site 331678002118 Q-loop/lid; other site 331678002119 ABC transporter signature motif; other site 331678002120 Walker B; other site 331678002121 D-loop; other site 331678002122 H-loop/switch region; other site 331678002123 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 331678002124 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 331678002125 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 331678002126 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 331678002127 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 331678002128 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 331678002129 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 331678002130 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331678002131 ATP binding site [chemical binding]; other site 331678002132 Mg++ binding site [ion binding]; other site 331678002133 motif III; other site 331678002134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678002135 nucleotide binding region [chemical binding]; other site 331678002136 ATP-binding site [chemical binding]; other site 331678002137 DbpA RNA binding domain; Region: DbpA; pfam03880 331678002138 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 331678002139 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678002140 putative metal binding site [ion binding]; other site 331678002141 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678002142 putative catalytic site [active] 331678002143 putative phosphate binding site [ion binding]; other site 331678002144 putative metal binding site [ion binding]; other site 331678002145 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 331678002146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331678002147 Beta-Casp domain; Region: Beta-Casp; cl12567 331678002148 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 331678002149 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 331678002150 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 331678002151 Int/Topo IB signature motif; other site 331678002152 active site 331678002153 16S rRNA methyltransferase B; Provisional; Region: PRK14904 331678002154 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 331678002155 putative RNA binding site [nucleotide binding]; other site 331678002156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 331678002157 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 331678002158 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 331678002159 homodimer interface [polypeptide binding]; other site 331678002160 substrate-cofactor binding pocket; other site 331678002161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678002162 catalytic residue [active] 331678002163 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 331678002164 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678002165 Virulence protein [General function prediction only]; Region: COG3943 331678002166 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 331678002167 Restriction endonuclease [Defense mechanisms]; Region: COG3587 331678002168 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 331678002169 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 331678002170 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 331678002171 seryl-tRNA synthetase; Provisional; Region: PRK05431 331678002172 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 331678002173 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 331678002174 dimer interface [polypeptide binding]; other site 331678002175 active site 331678002176 motif 1; other site 331678002177 motif 2; other site 331678002178 motif 3; other site 331678002179 GatB domain; Region: GatB_Yqey; cl11497 331678002180 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 331678002181 classical (c) SDRs; Region: SDR_c; cd05233 331678002182 NAD(P) binding site [chemical binding]; other site 331678002183 active site 331678002184 Transposase domain (DUF772); Region: DUF772; cl15789 331678002185 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 331678002186 Transposase domain (DUF772); Region: DUF772; cl15789 331678002187 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 331678002188 DNA-binding site [nucleotide binding]; DNA binding site 331678002189 RNA-binding motif; other site 331678002190 hypothetical protein; Reviewed; Region: PRK00024 331678002191 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 331678002192 MPN+ (JAMM) motif; other site 331678002193 Zinc-binding site [ion binding]; other site 331678002194 malate dehydrogenase; Reviewed; Region: PRK06223 331678002195 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 331678002196 NAD(P) binding site [chemical binding]; other site 331678002197 dimer interface [polypeptide binding]; other site 331678002198 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331678002199 substrate binding site [chemical binding]; other site 331678002200 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 331678002201 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 331678002202 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 331678002203 MutS domain I; Region: MutS_I; pfam01624 331678002204 MutS domain II; Region: MutS_II; pfam05188 331678002205 MutS family domain IV; Region: MutS_IV; pfam05190 331678002206 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 331678002207 Walker A/P-loop; other site 331678002208 ATP binding site [chemical binding]; other site 331678002209 Q-loop/lid; other site 331678002210 ABC transporter signature motif; other site 331678002211 Walker B; other site 331678002212 D-loop; other site 331678002213 H-loop/switch region; other site 331678002214 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 331678002215 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678002216 B12 binding site [chemical binding]; other site 331678002217 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002218 FeS/SAM binding site; other site 331678002219 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678002220 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678002221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002222 Walker A/P-loop; other site 331678002223 ATP binding site [chemical binding]; other site 331678002224 Q-loop/lid; other site 331678002225 ABC transporter signature motif; other site 331678002226 Walker B; other site 331678002227 D-loop; other site 331678002228 H-loop/switch region; other site 331678002229 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678002230 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331678002231 DNA binding residues [nucleotide binding] 331678002232 adenylate kinase; Provisional; Region: PRK14531 331678002233 Bacteriochlorophyll A protein; Region: BChl_A; pfam02327 331678002234 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 331678002235 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 331678002236 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 331678002237 putative active site [active] 331678002238 catalytic triad [active] 331678002239 putative dimer interface [polypeptide binding]; other site 331678002240 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 331678002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678002242 Walker A motif; other site 331678002243 ATP binding site [chemical binding]; other site 331678002244 Walker B motif; other site 331678002245 arginine finger; other site 331678002246 Helix-turn-helix domains; Region: HTH; cl00088 331678002247 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616 331678002248 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 331678002249 Predicted amidohydrolase [General function prediction only]; Region: COG0388 331678002250 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 331678002251 putative active site [active] 331678002252 catalytic triad [active] 331678002253 putative dimer interface [polypeptide binding]; other site 331678002254 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 331678002255 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 331678002256 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 331678002257 dimer interface [polypeptide binding]; other site 331678002258 decamer (pentamer of dimers) interface [polypeptide binding]; other site 331678002259 catalytic triad [active] 331678002260 peroxidatic and resolving cysteines [active] 331678002261 prolyl-tRNA synthetase; Provisional; Region: PRK08661 331678002262 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 331678002263 dimer interface [polypeptide binding]; other site 331678002264 motif 1; other site 331678002265 active site 331678002266 motif 2; other site 331678002267 motif 3; other site 331678002268 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 331678002269 anticodon binding site; other site 331678002270 zinc-binding site [ion binding]; other site 331678002271 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 331678002272 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 331678002273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002274 S-adenosylmethionine binding site [chemical binding]; other site 331678002275 Helix-turn-helix domains; Region: HTH; cl00088 331678002276 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 331678002277 HrcA protein C terminal domain; Region: HrcA; pfam01628 331678002278 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 331678002279 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 331678002280 dimer interface [polypeptide binding]; other site 331678002281 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 331678002282 chaperone protein DnaJ; Provisional; Region: PRK14281 331678002283 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 331678002284 HSP70 interaction site [polypeptide binding]; other site 331678002285 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 331678002286 substrate binding site [polypeptide binding]; other site 331678002287 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 331678002288 Zn binding sites [ion binding]; other site 331678002289 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 331678002290 dimer interface [polypeptide binding]; other site 331678002291 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 331678002292 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 331678002293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002294 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 331678002295 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 331678002296 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 331678002297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678002298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678002300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678002301 putative substrate translocation pore; other site 331678002302 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 331678002303 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 331678002304 Walker A/P-loop; other site 331678002305 ATP binding site [chemical binding]; other site 331678002306 Q-loop/lid; other site 331678002307 ABC transporter signature motif; other site 331678002308 Walker B; other site 331678002309 D-loop; other site 331678002310 H-loop/switch region; other site 331678002311 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 331678002312 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 331678002313 putative catalytic cysteine [active] 331678002314 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 331678002315 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 331678002316 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678002317 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 331678002318 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 331678002319 Cupin domain; Region: Cupin_2; cl09118 331678002320 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 331678002321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678002322 salt bridge; other site 331678002323 non-specific DNA binding site [nucleotide binding]; other site 331678002324 sequence-specific DNA binding site [nucleotide binding]; other site 331678002325 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678002326 active site 331678002327 NTP binding site [chemical binding]; other site 331678002328 metal binding triad [ion binding]; metal-binding site 331678002329 antibiotic binding site [chemical binding]; other site 331678002330 Protein of unknown function DUF86; Region: DUF86; cl01031 331678002331 Restriction endonuclease NotI; Region: NotI; pfam12183 331678002332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002333 Helix-turn-helix domains; Region: HTH; cl00088 331678002334 putative transposase OrfB; Reviewed; Region: PHA02517 331678002335 HTH-like domain; Region: HTH_21; pfam13276 331678002336 Integrase core domain; Region: rve; cl01316 331678002337 Integrase core domain; Region: rve_3; cl15866 331678002338 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 331678002339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331678002340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678002341 Fic/DOC family; Region: Fic; cl00960 331678002342 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331678002343 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678002344 B12 binding site [chemical binding]; other site 331678002345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002346 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331678002347 FeS/SAM binding site; other site 331678002348 gamma-glutamyl kinase; Provisional; Region: PRK05429 331678002349 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 331678002350 nucleotide binding site [chemical binding]; other site 331678002351 homotetrameric interface [polypeptide binding]; other site 331678002352 putative phosphate binding site [ion binding]; other site 331678002353 putative allosteric binding site; other site 331678002354 PUA domain; Region: PUA; cl00607 331678002355 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331678002356 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331678002357 metal binding site 2 [ion binding]; metal-binding site 331678002358 putative DNA binding helix; other site 331678002359 metal binding site 1 [ion binding]; metal-binding site 331678002360 dimer interface [polypeptide binding]; other site 331678002361 structural Zn2+ binding site [ion binding]; other site 331678002362 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678002363 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 331678002364 active site 331678002365 catalytic residues [active] 331678002366 metal binding site [ion binding]; metal-binding site 331678002367 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 331678002368 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 331678002369 putative active site [active] 331678002370 substrate binding site [chemical binding]; other site 331678002371 putative cosubstrate binding site; other site 331678002372 catalytic site [active] 331678002373 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 331678002374 substrate binding site [chemical binding]; other site 331678002375 GTP-binding protein LepA; Provisional; Region: PRK05433 331678002376 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 331678002377 G1 box; other site 331678002378 putative GEF interaction site [polypeptide binding]; other site 331678002379 GTP/Mg2+ binding site [chemical binding]; other site 331678002380 Switch I region; other site 331678002381 G2 box; other site 331678002382 G3 box; other site 331678002383 Switch II region; other site 331678002384 G4 box; other site 331678002385 G5 box; other site 331678002386 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 331678002387 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 331678002388 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 331678002389 signal peptidase I; Provisional; Region: PRK10861 331678002390 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331678002391 Catalytic site [active] 331678002392 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331678002393 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 331678002394 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 331678002395 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331678002396 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 331678002397 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 331678002398 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331678002399 protein binding site [polypeptide binding]; other site 331678002400 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331678002401 protein binding site [polypeptide binding]; other site 331678002402 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 331678002403 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 331678002404 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 331678002405 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 331678002406 substrate binding site [chemical binding]; other site 331678002407 dimer interface [polypeptide binding]; other site 331678002408 catalytic triad [active] 331678002409 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 331678002410 ThiC-associated domain; Region: ThiC-associated; pfam13667 331678002411 ThiC family; Region: ThiC; cl08031 331678002412 PUCC protein; Region: PUCC; pfam03209 331678002413 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 331678002414 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002415 FeS/SAM binding site; other site 331678002416 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 331678002417 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331678002418 ATP binding site [chemical binding]; other site 331678002419 Mg++ binding site [ion binding]; other site 331678002420 motif III; other site 331678002421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678002422 nucleotide binding region [chemical binding]; other site 331678002423 ATP-binding site [chemical binding]; other site 331678002424 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 331678002425 active site 331678002426 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 331678002427 Catalytic site [active] 331678002428 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 331678002429 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 331678002430 active site 331678002431 DNA binding site [nucleotide binding] 331678002432 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 331678002433 serine acetyltransferase; Provisional; Region: cysE; PRK11132 331678002434 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 331678002435 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 331678002436 trimer interface [polypeptide binding]; other site 331678002437 active site 331678002438 substrate binding site [chemical binding]; other site 331678002439 CoA binding site [chemical binding]; other site 331678002440 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 331678002441 Tetramer interface [polypeptide binding]; other site 331678002442 active site 331678002443 FMN-binding site [chemical binding]; other site 331678002444 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 331678002445 dimer interface [polypeptide binding]; other site 331678002446 active site 331678002447 aspartate-rich active site metal binding site; other site 331678002448 allosteric magnesium binding site [ion binding]; other site 331678002449 Schiff base residues; other site 331678002450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331678002451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678002452 ATP binding site [chemical binding]; other site 331678002453 Mg2+ binding site [ion binding]; other site 331678002454 G-X-G motif; other site 331678002455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002456 active site 331678002457 phosphorylation site [posttranslational modification] 331678002458 intermolecular recognition site; other site 331678002459 dimerization interface [polypeptide binding]; other site 331678002460 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002462 active site 331678002463 phosphorylation site [posttranslational modification] 331678002464 intermolecular recognition site; other site 331678002465 dimerization interface [polypeptide binding]; other site 331678002466 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 331678002467 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 331678002468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331678002469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678002470 ATP binding site [chemical binding]; other site 331678002471 Mg2+ binding site [ion binding]; other site 331678002472 G-X-G motif; other site 331678002473 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002475 active site 331678002476 phosphorylation site [posttranslational modification] 331678002477 intermolecular recognition site; other site 331678002478 dimerization interface [polypeptide binding]; other site 331678002479 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002481 active site 331678002482 phosphorylation site [posttranslational modification] 331678002483 intermolecular recognition site; other site 331678002484 dimerization interface [polypeptide binding]; other site 331678002485 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 331678002486 active site 331678002487 RmuC family; Region: RmuC; pfam02646 331678002488 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 331678002489 active site 331678002490 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 331678002491 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 331678002492 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 331678002493 domain interfaces; other site 331678002494 active site 331678002495 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 331678002496 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 331678002497 tRNA; other site 331678002498 putative tRNA binding site [nucleotide binding]; other site 331678002499 putative NADP binding site [chemical binding]; other site 331678002500 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 331678002501 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331678002502 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 331678002503 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 331678002504 G1 box; other site 331678002505 putative GEF interaction site [polypeptide binding]; other site 331678002506 GTP/Mg2+ binding site [chemical binding]; other site 331678002507 Switch I region; other site 331678002508 G2 box; other site 331678002509 G3 box; other site 331678002510 Switch II region; other site 331678002511 G4 box; other site 331678002512 G5 box; other site 331678002513 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 331678002514 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 331678002515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002516 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 331678002517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678002518 DNA binding residues [nucleotide binding] 331678002519 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 331678002520 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 331678002521 putative NAD(P) binding site [chemical binding]; other site 331678002522 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 331678002523 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331678002524 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 331678002525 peptide binding site [polypeptide binding]; other site 331678002526 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 331678002527 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 331678002528 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 331678002529 trimer interface [polypeptide binding]; other site 331678002530 active site 331678002531 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331678002532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002533 active site 331678002534 phosphorylation site [posttranslational modification] 331678002535 intermolecular recognition site; other site 331678002536 dimerization interface [polypeptide binding]; other site 331678002537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678002538 Walker A motif; other site 331678002539 ATP binding site [chemical binding]; other site 331678002540 Walker B motif; other site 331678002541 arginine finger; other site 331678002542 Helix-turn-helix domains; Region: HTH; cl00088 331678002543 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 331678002544 Probable Catalytic site; other site 331678002545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678002546 phytoene desaturase; Region: phytoene_desat; TIGR02731 331678002547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002548 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331678002549 Helix-turn-helix domains; Region: HTH; cl00088 331678002550 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 331678002551 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 331678002552 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331678002553 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 331678002554 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002555 Type III pantothenate kinase; Region: Pan_kinase; cl09130 331678002556 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 331678002557 active site 331678002558 dimer interface [polypeptide binding]; other site 331678002559 metal binding site [ion binding]; metal-binding site 331678002560 shikimate kinase; Reviewed; Region: aroK; PRK00131 331678002561 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 331678002562 ADP binding site [chemical binding]; other site 331678002563 magnesium binding site [ion binding]; other site 331678002564 putative shikimate binding site; other site 331678002565 glycerol kinase; Provisional; Region: glpK; PRK00047 331678002566 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 331678002567 N- and C-terminal domain interface [polypeptide binding]; other site 331678002568 active site 331678002569 MgATP binding site [chemical binding]; other site 331678002570 catalytic site [active] 331678002571 metal binding site [ion binding]; metal-binding site 331678002572 glycerol binding site [chemical binding]; other site 331678002573 homotetramer interface [polypeptide binding]; other site 331678002574 homodimer interface [polypeptide binding]; other site 331678002575 FBP binding site [chemical binding]; other site 331678002576 protein IIAGlc interface [polypeptide binding]; other site 331678002577 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 331678002578 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331678002579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002580 FeS/SAM binding site; other site 331678002581 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 331678002582 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 331678002583 transcriptional activator RfaH; Region: RfaH; TIGR01955 331678002584 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 331678002585 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678002586 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 331678002587 putative NAD(P) binding site [chemical binding]; other site 331678002588 active site 331678002589 putative substrate binding site [chemical binding]; other site 331678002590 Divergent AAA domain; Region: AAA_4; pfam04326 331678002591 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 331678002592 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 331678002593 dimer interface [polypeptide binding]; other site 331678002594 putative anticodon binding site; other site 331678002595 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 331678002596 motif 1; other site 331678002597 active site 331678002598 motif 2; other site 331678002599 motif 3; other site 331678002600 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 331678002601 active site lid residues [active] 331678002602 substrate binding pocket [chemical binding]; other site 331678002603 catalytic residues [active] 331678002604 substrate-Mg2+ binding site; other site 331678002605 aspartate-rich region 1; other site 331678002606 aspartate-rich region 2; other site 331678002607 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 331678002608 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 331678002609 HflX GTPase family; Region: HflX; cd01878 331678002610 G1 box; other site 331678002611 GTP/Mg2+ binding site [chemical binding]; other site 331678002612 Switch I region; other site 331678002613 G2 box; other site 331678002614 G3 box; other site 331678002615 Switch II region; other site 331678002616 G4 box; other site 331678002617 G5 box; other site 331678002618 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 331678002619 Protein of unknown function (DUF456); Region: DUF456; cl01069 331678002620 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 331678002621 Putative zinc ribbon domain; Region: DUF164; pfam02591 331678002622 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 331678002623 diaminopimelate decarboxylase; Region: lysA; TIGR01048 331678002624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 331678002625 active site 331678002626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331678002627 substrate binding site [chemical binding]; other site 331678002628 catalytic residues [active] 331678002629 dimer interface [polypeptide binding]; other site 331678002630 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 331678002631 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 331678002632 FAD binding site [chemical binding]; other site 331678002633 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 331678002634 Competence protein; Region: Competence; cl00471 331678002635 Cupin domain; Region: Cupin_2; cl09118 331678002636 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 331678002637 dimer interface [polypeptide binding]; other site 331678002638 ADP-ribose binding site [chemical binding]; other site 331678002639 active site 331678002640 nudix motif; other site 331678002641 metal binding site [ion binding]; metal-binding site 331678002642 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 331678002643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678002644 dimer interface [polypeptide binding]; other site 331678002645 conserved gate region; other site 331678002646 putative PBP binding loops; other site 331678002647 ABC-ATPase subunit interface; other site 331678002648 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 331678002649 5S rRNA interface [nucleotide binding]; other site 331678002650 CTC domain interface [polypeptide binding]; other site 331678002651 L16 interface [polypeptide binding]; other site 331678002652 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 331678002653 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 331678002654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678002655 active site 331678002656 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 331678002657 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 331678002658 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 331678002659 trimer interface [polypeptide binding]; other site 331678002660 active site 331678002661 UDP-GlcNAc binding site [chemical binding]; other site 331678002662 lipid binding site [chemical binding]; lipid-binding site 331678002663 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 331678002664 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 331678002665 Protein of unknown function, DUF547; Region: DUF547; pfam04784 331678002666 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 331678002667 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 331678002668 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331678002669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002670 active site 331678002671 phosphorylation site [posttranslational modification] 331678002672 intermolecular recognition site; other site 331678002673 dimerization interface [polypeptide binding]; other site 331678002674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331678002675 DNA binding site [nucleotide binding] 331678002676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 331678002677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678002678 dimer interface [polypeptide binding]; other site 331678002679 phosphorylation site [posttranslational modification] 331678002680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678002681 ATP binding site [chemical binding]; other site 331678002682 Mg2+ binding site [ion binding]; other site 331678002683 G-X-G motif; other site 331678002684 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 331678002685 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 331678002686 Cytochrome c; Region: Cytochrom_C; cl11414 331678002687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331678002688 ligand binding site [chemical binding]; other site 331678002689 Phosphate-starvation-inducible E; Region: PsiE; cl01264 331678002690 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678002691 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 331678002692 FtsX-like permease family; Region: FtsX; cl15850 331678002693 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678002694 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 331678002695 FtsX-like permease family; Region: FtsX; cl15850 331678002696 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678002697 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 331678002698 Walker A/P-loop; other site 331678002699 ATP binding site [chemical binding]; other site 331678002700 Q-loop/lid; other site 331678002701 ABC transporter signature motif; other site 331678002702 Walker B; other site 331678002703 D-loop; other site 331678002704 H-loop/switch region; other site 331678002705 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678002706 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678002707 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678002708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 331678002709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 331678002710 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 331678002711 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 331678002712 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678002713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002714 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 331678002715 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 331678002716 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 331678002717 oligomerization interface [polypeptide binding]; other site 331678002718 active site 331678002719 metal binding site [ion binding]; metal-binding site 331678002720 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 331678002721 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 331678002722 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 331678002723 putative active site [active] 331678002724 catalytic triad [active] 331678002725 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 331678002726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678002727 putative substrate translocation pore; other site 331678002728 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 331678002729 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 331678002730 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955 331678002731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678002732 Walker A motif; other site 331678002733 ATP binding site [chemical binding]; other site 331678002734 Walker B motif; other site 331678002735 arginine finger; other site 331678002736 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 331678002737 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 331678002738 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 331678002739 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 331678002740 dimer interface [polypeptide binding]; other site 331678002741 anticodon binding site; other site 331678002742 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 331678002743 homodimer interface [polypeptide binding]; other site 331678002744 motif 1; other site 331678002745 active site 331678002746 motif 2; other site 331678002747 GAD domain; Region: GAD; pfam02938 331678002748 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 331678002749 active site 331678002750 motif 3; other site 331678002751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 331678002752 Helix-turn-helix domains; Region: HTH; cl00088 331678002753 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678002755 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 331678002756 active site 331678002757 FMN binding site [chemical binding]; other site 331678002758 substrate binding site [chemical binding]; other site 331678002759 putative catalytic residue [active] 331678002760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002761 S-adenosylmethionine binding site [chemical binding]; other site 331678002762 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678002763 B12 binding site [chemical binding]; other site 331678002764 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678002765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002766 FeS/SAM binding site; other site 331678002767 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331678002768 CoenzymeA binding site [chemical binding]; other site 331678002769 subunit interaction site [polypeptide binding]; other site 331678002770 PHB binding site; other site 331678002771 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 331678002772 substrate binding site; other site 331678002773 dimer interface; other site 331678002774 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 331678002775 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 331678002776 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 331678002777 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678002778 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 331678002779 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 331678002780 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 331678002781 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678002782 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 331678002783 thymidylate kinase; Validated; Region: tmk; PRK00698 331678002784 TMP-binding site; other site 331678002785 ATP-binding site [chemical binding]; other site 331678002786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678002787 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 331678002788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002789 NAD(P) binding site [chemical binding]; other site 331678002790 active site 331678002791 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 331678002792 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 331678002793 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331678002794 dimer interface [polypeptide binding]; other site 331678002795 PYR/PP interface [polypeptide binding]; other site 331678002796 TPP binding site [chemical binding]; other site 331678002797 substrate binding site [chemical binding]; other site 331678002798 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 331678002799 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 331678002800 TPP-binding site [chemical binding]; other site 331678002801 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 331678002802 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678002803 Staphylococcal nuclease homologues; Region: SNc; smart00318 331678002804 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 331678002805 Catalytic site; other site 331678002806 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 331678002807 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002808 Walker A/P-loop; other site 331678002809 ATP binding site [chemical binding]; other site 331678002810 ABC transporter signature motif; other site 331678002811 Walker B; other site 331678002812 D-loop; other site 331678002813 H-loop/switch region; other site 331678002814 ABC transporter; Region: ABC_tran_2; pfam12848 331678002815 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 331678002816 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 331678002817 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678002818 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 331678002819 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 331678002820 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 331678002821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678002822 RNA binding surface [nucleotide binding]; other site 331678002823 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 331678002824 active site 331678002825 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 331678002826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678002828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331678002829 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 331678002830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002831 Walker A motif; other site 331678002832 ATP binding site [chemical binding]; other site 331678002833 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 331678002834 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 331678002835 metal ion-dependent adhesion site (MIDAS); other site 331678002836 magnesium chelatase, H subunit; Region: BchH; TIGR02025 331678002837 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678002838 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678002839 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 331678002840 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 331678002841 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 331678002842 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 331678002843 active site 331678002844 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 331678002845 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 331678002846 Protein of unknown function (DUF497); Region: DUF497; cl01108 331678002847 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678002848 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 331678002849 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 331678002850 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678002851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002852 S-adenosylmethionine binding site [chemical binding]; other site 331678002853 Putative addiction module component; Region: Unstab_antitox; cl09921 331678002854 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678002855 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 331678002856 ArsC family; Region: ArsC; pfam03960 331678002857 putative catalytic residues [active] 331678002858 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678002859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002860 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 331678002861 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678002862 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678002863 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678002864 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678002865 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678002866 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678002867 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 331678002868 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331678002869 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 331678002870 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 331678002871 catalytic residues [active] 331678002872 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 331678002873 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 331678002874 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 331678002875 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 331678002876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002877 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678002878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331678002879 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678002880 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002881 Protein of unknown function DUF86; Region: DUF86; cl01031 331678002882 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 331678002883 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 331678002884 putative NAD(P) binding site [chemical binding]; other site 331678002885 putative substrate binding site [chemical binding]; other site 331678002886 catalytic Zn binding site [ion binding]; other site 331678002887 structural Zn binding site [ion binding]; other site 331678002888 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331678002889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678002890 active site 331678002891 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 331678002892 UbiA prenyltransferase family; Region: UbiA; cl00337 331678002893 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 331678002894 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 331678002895 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 331678002896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002897 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 331678002898 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 331678002899 NADP binding site [chemical binding]; other site 331678002900 homopentamer interface [polypeptide binding]; other site 331678002901 substrate binding site [chemical binding]; other site 331678002902 active site 331678002903 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 331678002904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678002905 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 331678002906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678002907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678002908 homodimer interface [polypeptide binding]; other site 331678002909 catalytic residue [active] 331678002910 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 331678002911 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678002912 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678002913 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 331678002914 putative active site [active] 331678002915 catalytic residue [active] 331678002916 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 331678002917 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 331678002918 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678002919 putative catalytic site [active] 331678002920 putative metal binding site [ion binding]; other site 331678002921 putative phosphate binding site [ion binding]; other site 331678002922 EamA-like transporter family; Region: EamA; cl01037 331678002923 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 331678002924 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 331678002925 ATP binding site [chemical binding]; other site 331678002926 active site 331678002927 substrate binding site [chemical binding]; other site 331678002928 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 331678002929 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331678002930 TPP-binding site [chemical binding]; other site 331678002931 dimer interface [polypeptide binding]; other site 331678002932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002933 S-adenosylmethionine binding site [chemical binding]; other site 331678002934 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 331678002935 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 331678002936 active site 331678002937 (T/H)XGH motif; other site 331678002938 aspartate aminotransferase; Provisional; Region: PRK05764 331678002939 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678002940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678002941 homodimer interface [polypeptide binding]; other site 331678002942 catalytic residue [active] 331678002943 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 331678002944 putative acyl-acceptor binding pocket; other site 331678002945 PSP1 C-terminal conserved region; Region: PSP1; cl00770 331678002946 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 331678002947 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 331678002948 active site 331678002949 HIGH motif; other site 331678002950 KMSKS motif; other site 331678002951 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 331678002952 tRNA binding surface [nucleotide binding]; other site 331678002953 anticodon binding site; other site 331678002954 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 331678002955 dimer interface [polypeptide binding]; other site 331678002956 putative tRNA-binding site [nucleotide binding]; other site 331678002957 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 331678002958 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 331678002959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002960 S-adenosylmethionine binding site [chemical binding]; other site 331678002961 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 331678002962 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 331678002963 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 331678002964 anti sigma factor interaction site; other site 331678002965 regulatory phosphorylation site [posttranslational modification]; other site 331678002966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678002967 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 331678002968 Maf-like protein; Region: Maf; pfam02545 331678002969 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 331678002970 active site 331678002971 dimer interface [polypeptide binding]; other site 331678002972 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 331678002973 Sodium:solute symporter family; Region: SSF; cl00456 331678002974 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 331678002975 substrate binding site [chemical binding]; other site 331678002976 ATP binding site [chemical binding]; other site 331678002977 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 331678002978 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 331678002979 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 331678002980 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 331678002981 dimerization interface 3.5A [polypeptide binding]; other site 331678002982 active site 331678002983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 331678002984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331678002985 catalytic residue [active] 331678002986 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 331678002987 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 331678002988 putative peptidoglycan binding site; other site 331678002989 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 331678002990 putative peptidoglycan binding site; other site 331678002991 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 331678002992 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 331678002993 putative peptidoglycan binding site; other site 331678002994 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 331678002995 putative peptidoglycan binding site; other site 331678002996 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678002997 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678002998 P loop; other site 331678002999 Nucleotide binding site [chemical binding]; other site 331678003000 DTAP/Switch II; other site 331678003001 Switch I; other site 331678003002 NeuB family; Region: NeuB; cl00496 331678003003 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331678003004 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 331678003005 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 331678003006 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 331678003007 Walker A/P-loop; other site 331678003008 ATP binding site [chemical binding]; other site 331678003009 Q-loop/lid; other site 331678003010 ABC transporter signature motif; other site 331678003011 Walker B; other site 331678003012 D-loop; other site 331678003013 H-loop/switch region; other site 331678003014 Cobalt transport protein; Region: CbiQ; cl00463 331678003015 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 331678003016 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 331678003017 nickel responsive regulator; Provisional; Region: PRK04460 331678003018 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 331678003019 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 331678003020 Nitrogen regulatory protein P-II; Region: P-II; cl00412 331678003021 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678003022 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 331678003023 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 331678003024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 331678003025 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 331678003026 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 331678003027 active site 331678003028 dimer interface [polypeptide binding]; other site 331678003029 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 331678003030 dimer interface [polypeptide binding]; other site 331678003031 active site 331678003032 ApbE family; Region: ApbE; cl00643 331678003033 integron integrase; Region: integrase_gron; TIGR02249 331678003034 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 331678003035 Int/Topo IB signature motif; other site 331678003036 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 331678003037 putative active site [active] 331678003038 catalytic site [active] 331678003039 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 331678003040 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678003041 ATP binding site [chemical binding]; other site 331678003042 putative Mg++ binding site [ion binding]; other site 331678003043 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678003044 nucleotide binding region [chemical binding]; other site 331678003045 ATP-binding site [chemical binding]; other site 331678003046 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 331678003047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003049 Restriction endonuclease [Defense mechanisms]; Region: COG3587 331678003050 Protein of unknown function DUF262; Region: DUF262; cl14890 331678003051 Protein of unknown function DUF262; Region: DUF262; cl14890 331678003052 AAA domain; Region: AAA_13; pfam13166 331678003053 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003054 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 331678003055 putative active site [active] 331678003056 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331678003057 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 331678003058 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003059 Protein of unknown function DUF262; Region: DUF262; cl14890 331678003060 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 331678003061 active site 331678003062 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 331678003063 Uncharacterized conserved protein [Function unknown]; Region: COG3586 331678003064 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 331678003065 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678003066 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 331678003067 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 331678003068 SprT homologues; Region: SprT; cl01182 331678003069 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003070 Ligand Binding Site [chemical binding]; other site 331678003071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003072 Ligand Binding Site [chemical binding]; other site 331678003073 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 331678003074 Sulfate transporter family; Region: Sulfate_transp; cl15842 331678003075 Sulfate transporter family; Region: Sulfate_transp; cl15842 331678003076 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 331678003077 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 331678003078 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 331678003079 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 331678003080 dimer interface [polypeptide binding]; other site 331678003081 active site residues [active] 331678003082 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 331678003083 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 331678003084 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003085 Ligand Binding Site [chemical binding]; other site 331678003086 membrane ATPase/protein kinase; Provisional; Region: PRK09435 331678003087 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 331678003088 Walker A; other site 331678003089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003090 G4 box; other site 331678003091 G5 box; other site 331678003092 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 331678003093 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 331678003094 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 331678003095 active site 331678003096 substrate binding site [chemical binding]; other site 331678003097 coenzyme B12 binding site [chemical binding]; other site 331678003098 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 331678003099 B12 binding site [chemical binding]; other site 331678003100 cobalt ligand [ion binding]; other site 331678003101 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 331678003102 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331678003103 trimer interface [polypeptide binding]; other site 331678003104 oxyanion hole (OAH) forming residues; other site 331678003105 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 331678003106 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 331678003107 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331678003108 dimer interface [polypeptide binding]; other site 331678003109 substrate binding site [chemical binding]; other site 331678003110 metal binding site [ion binding]; metal-binding site 331678003111 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 331678003112 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 331678003113 AMP-binding enzyme; Region: AMP-binding; cl15778 331678003114 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331678003115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003116 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 331678003117 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331678003118 PYR/PP interface [polypeptide binding]; other site 331678003119 dimer interface [polypeptide binding]; other site 331678003120 TPP binding site [chemical binding]; other site 331678003121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331678003122 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 331678003123 recombination protein RecR; Reviewed; Region: recR; PRK00076 331678003124 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 331678003125 RecR protein; Region: RecR; pfam02132 331678003126 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 331678003127 putative active site [active] 331678003128 putative metal-binding site [ion binding]; other site 331678003129 tetramer interface [polypeptide binding]; other site 331678003130 phytoene desaturase; Region: phytoene_desat; TIGR02731 331678003131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003132 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 331678003133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003134 S-adenosylmethionine binding site [chemical binding]; other site 331678003135 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 331678003136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331678003137 active site 331678003138 catalytic tetrad [active] 331678003139 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 331678003140 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 331678003141 G1 box; other site 331678003142 putative GEF interaction site [polypeptide binding]; other site 331678003143 GTP/Mg2+ binding site [chemical binding]; other site 331678003144 Switch I region; other site 331678003145 G2 box; other site 331678003146 G3 box; other site 331678003147 Switch II region; other site 331678003148 G4 box; other site 331678003149 G5 box; other site 331678003150 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 331678003151 phosphoglucomutase; Validated; Region: PRK07564 331678003152 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 331678003153 active site 331678003154 substrate binding site [chemical binding]; other site 331678003155 metal binding site [ion binding]; metal-binding site 331678003156 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 331678003157 dimer interface [polypeptide binding]; other site 331678003158 substrate binding site [chemical binding]; other site 331678003159 metal binding sites [ion binding]; metal-binding site 331678003160 fumarate hydratase; Reviewed; Region: fumC; PRK00485 331678003161 Class II fumarases; Region: Fumarase_classII; cd01362 331678003162 active site 331678003163 tetramer interface [polypeptide binding]; other site 331678003164 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 331678003165 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 331678003166 ATP cone domain; Region: ATP-cone; pfam03477 331678003167 Class III ribonucleotide reductase; Region: RNR_III; cd01675 331678003168 effector binding site; other site 331678003169 active site 331678003170 Zn binding site [ion binding]; other site 331678003171 glycine loop; other site 331678003172 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 331678003173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003174 FeS/SAM binding site; other site 331678003175 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 331678003176 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 331678003177 dimerization interface [polypeptide binding]; other site 331678003178 active site 331678003179 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678003180 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 331678003181 heat shock protein 90; Provisional; Region: PRK05218 331678003182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 331678003183 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 331678003184 diiron binding motif [ion binding]; other site 331678003185 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 331678003186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 331678003187 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 331678003188 AAA domain; Region: AAA_33; pfam13671 331678003189 ATP-binding site [chemical binding]; other site 331678003190 Gluconate-6-phosphate binding site [chemical binding]; other site 331678003191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003192 Ligand Binding Site [chemical binding]; other site 331678003193 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 331678003194 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 331678003195 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 331678003196 active site 331678003197 catalytic residues [active] 331678003198 metal binding site [ion binding]; metal-binding site 331678003199 homodimer binding site [polypeptide binding]; other site 331678003200 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331678003201 carboxyltransferase (CT) interaction site; other site 331678003202 biotinylation site [posttranslational modification]; other site 331678003203 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 331678003204 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003205 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003206 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003207 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003208 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 331678003209 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 331678003210 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 331678003211 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 331678003212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678003213 putative ADP-binding pocket [chemical binding]; other site 331678003214 DNA polymerase III subunit alpha; partial due to frameshift 331678003215 DNA polymerase III subunit alpha; partial due to frameshift 331678003216 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331678003217 catalytic residues [active] 331678003218 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 331678003219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678003221 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 331678003222 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 331678003223 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 331678003224 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 331678003225 AsmA-like C-terminal region; Region: AsmA_2; cl15864 331678003226 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 331678003227 putative active site [active] 331678003228 putative metal binding site [ion binding]; other site 331678003229 SdiA-regulated; Region: SdiA-regulated; cd09971 331678003230 putative active site [active] 331678003231 CotH protein; Region: CotH; pfam08757 331678003232 Surface antigen; Region: Bac_surface_Ag; cl03097 331678003233 cyclase homology domain; Region: CHD; cd07302 331678003234 nucleotidyl binding site; other site 331678003235 metal binding site [ion binding]; metal-binding site 331678003236 dimer interface [polypeptide binding]; other site 331678003237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678003238 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 331678003239 active site 331678003240 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331678003241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678003242 motif II; other site 331678003243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003244 hypothetical protein; Provisional; Region: PRK08317 331678003245 S-adenosylmethionine binding site [chemical binding]; other site 331678003246 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 331678003247 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 331678003248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331678003249 putative acyl-acceptor binding pocket; other site 331678003250 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 331678003251 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331678003252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331678003253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331678003254 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 331678003255 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 331678003256 Walker A/P-loop; other site 331678003257 ATP binding site [chemical binding]; other site 331678003258 Q-loop/lid; other site 331678003259 ABC transporter signature motif; other site 331678003260 Walker B; other site 331678003261 D-loop; other site 331678003262 H-loop/switch region; other site 331678003263 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 331678003264 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 331678003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003266 dimer interface [polypeptide binding]; other site 331678003267 conserved gate region; other site 331678003268 putative PBP binding loops; other site 331678003269 ABC-ATPase subunit interface; other site 331678003270 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 331678003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003272 dimer interface [polypeptide binding]; other site 331678003273 conserved gate region; other site 331678003274 putative PBP binding loops; other site 331678003275 ABC-ATPase subunit interface; other site 331678003276 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 331678003277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003278 conserved gate region; other site 331678003279 putative PBP binding loops; other site 331678003280 ABC-ATPase subunit interface; other site 331678003281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003282 dimer interface [polypeptide binding]; other site 331678003283 conserved gate region; other site 331678003284 putative PBP binding loops; other site 331678003285 ABC-ATPase subunit interface; other site 331678003286 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275 331678003287 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 331678003288 Walker A/P-loop; other site 331678003289 ATP binding site [chemical binding]; other site 331678003290 Q-loop/lid; other site 331678003291 ABC transporter signature motif; other site 331678003292 Walker B; other site 331678003293 D-loop; other site 331678003294 H-loop/switch region; other site 331678003295 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 331678003296 PhoU domain; Region: PhoU; pfam01895 331678003297 PhoU domain; Region: PhoU; pfam01895 331678003298 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 331678003299 PhoU domain; Region: PhoU; pfam01895 331678003300 DoxX-like family; Region: DoxX_3; pfam13781 331678003301 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003302 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678003303 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678003304 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003306 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 331678003307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003308 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678003309 active site 331678003310 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 331678003311 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678003312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678003314 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 331678003315 Integrase core domain; Region: rve; cl01316 331678003316 Winged helix-turn helix; Region: HTH_29; pfam13551 331678003317 Helix-turn-helix domains; Region: HTH; cl00088 331678003318 Helix-turn-helix domains; Region: HTH; cl00088 331678003319 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 331678003320 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 331678003321 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 331678003322 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 331678003323 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 331678003324 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003325 Putative addiction module component; Region: Unstab_antitox; cl09921 331678003326 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678003327 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 331678003328 Protein of unknown function (DUF497); Region: DUF497; cl01108 331678003329 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 331678003330 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331678003331 FAD binding domain; Region: FAD_binding_4; pfam01565 331678003332 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 331678003333 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331678003334 Cysteine-rich domain; Region: CCG; pfam02754 331678003335 radical SAM modification target peptide, GSU_1558 family; Region: selen_ocin; TIGR04081 331678003336 selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082 331678003337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003338 FeS/SAM binding site; other site 331678003339 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 331678003340 aminotransferase; Validated; Region: PRK08175 331678003341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678003342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678003343 homodimer interface [polypeptide binding]; other site 331678003344 catalytic residue [active] 331678003345 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 331678003346 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 331678003347 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 331678003348 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 331678003349 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 331678003350 putative substrate binding site [chemical binding]; other site 331678003351 putative ATP binding site [chemical binding]; other site 331678003352 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 331678003353 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 331678003354 dimerization interface [polypeptide binding]; other site 331678003355 ATP binding site [chemical binding]; other site 331678003356 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 331678003357 dimerization interface [polypeptide binding]; other site 331678003358 ATP binding site [chemical binding]; other site 331678003359 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 331678003360 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 331678003361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678003362 nucleotide binding region [chemical binding]; other site 331678003363 ATP-binding site [chemical binding]; other site 331678003364 SEC-C motif; Region: SEC-C; pfam02810 331678003365 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 331678003366 DHH family; Region: DHH; pfam01368 331678003367 DHHA1 domain; Region: DHHA1; pfam02272 331678003368 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678003369 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678003370 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 331678003371 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331678003372 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 331678003373 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 331678003374 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 331678003375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003376 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 331678003377 dimer interface [polypeptide binding]; other site 331678003378 substrate binding site [chemical binding]; other site 331678003379 ATP binding site [chemical binding]; other site 331678003380 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331678003381 thiamine phosphate binding site [chemical binding]; other site 331678003382 active site 331678003383 pyrophosphate binding site [ion binding]; other site 331678003384 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331678003385 thiamine phosphate binding site [chemical binding]; other site 331678003386 active site 331678003387 pyrophosphate binding site [ion binding]; other site 331678003388 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 331678003389 homotrimer interaction site [polypeptide binding]; other site 331678003390 putative active site [active] 331678003391 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 331678003392 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331678003393 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331678003394 protein binding site [polypeptide binding]; other site 331678003395 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331678003396 Catalytic dyad [active] 331678003397 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 331678003398 putative lipid binding site [chemical binding]; other site 331678003399 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 331678003400 putative lipid binding site [chemical binding]; other site 331678003401 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 331678003402 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331678003403 putative ribose interaction site [chemical binding]; other site 331678003404 putative ADP binding site [chemical binding]; other site 331678003405 signal recognition particle protein; Provisional; Region: PRK10867 331678003406 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 331678003407 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 331678003408 P loop; other site 331678003409 GTP binding site [chemical binding]; other site 331678003410 Signal peptide binding domain; Region: SRP_SPB; pfam02978 331678003411 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 331678003412 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 331678003413 RimM N-terminal domain; Region: RimM; pfam01782 331678003414 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 331678003415 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 331678003416 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 331678003417 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331678003418 endonuclease III; Region: ENDO3c; smart00478 331678003419 minor groove reading motif; other site 331678003420 helix-hairpin-helix signature motif; other site 331678003421 substrate binding pocket [chemical binding]; other site 331678003422 active site 331678003423 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 331678003424 AMP-binding enzyme; Region: AMP-binding; cl15778 331678003425 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331678003426 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678003427 P-loop; other site 331678003428 Magnesium ion binding site [ion binding]; other site 331678003429 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678003430 Magnesium ion binding site [ion binding]; other site 331678003431 CHAD domain; Region: CHAD; cl10506 331678003432 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 331678003433 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 331678003434 ligand binding site [chemical binding]; other site 331678003435 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 331678003436 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 331678003437 putative NADP binding site [chemical binding]; other site 331678003438 putative substrate binding site [chemical binding]; other site 331678003439 active site 331678003440 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 331678003441 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331678003442 ligand binding site [chemical binding]; other site 331678003443 flexible hinge region; other site 331678003444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 331678003445 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 331678003446 metal binding triad; other site 331678003447 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678003448 active site 331678003449 substrate binding site [chemical binding]; other site 331678003450 catalytic site [active] 331678003451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003452 S-adenosylmethionine binding site [chemical binding]; other site 331678003453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 331678003454 active site residue [active] 331678003455 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 331678003456 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 331678003457 active site residue [active] 331678003458 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 331678003459 active site residue [active] 331678003460 probable methyltransferase; Region: TIGR03438 331678003461 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 331678003462 Predicted amidohydrolase [General function prediction only]; Region: COG0388 331678003463 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 331678003464 putative active site [active] 331678003465 catalytic triad [active] 331678003466 putative dimer interface [polypeptide binding]; other site 331678003467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678003468 Fic/DOC family; Region: Fic; cl00960 331678003469 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331678003470 Putative addiction module component; Region: Unstab_antitox; cl09921 331678003471 dihydroorotase; Validated; Region: pyrC; PRK09357 331678003472 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331678003473 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 331678003474 active site 331678003475 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 331678003476 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 331678003477 polyphosphate kinase; Provisional; Region: PRK05443 331678003478 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 331678003479 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 331678003480 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 331678003481 putative domain interface [polypeptide binding]; other site 331678003482 putative active site [active] 331678003483 catalytic site [active] 331678003484 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 331678003485 putative domain interface [polypeptide binding]; other site 331678003486 putative active site [active] 331678003487 catalytic site [active] 331678003488 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 331678003489 FOG: CBS domain [General function prediction only]; Region: COG0517 331678003490 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 331678003491 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331678003492 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 331678003493 metal binding site [ion binding]; metal-binding site 331678003494 dimer interface [polypeptide binding]; other site 331678003495 hypothetical protein; Provisional; Region: PRK08185 331678003496 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 331678003497 intersubunit interface [polypeptide binding]; other site 331678003498 active site 331678003499 zinc binding site [ion binding]; other site 331678003500 Na+ binding site [ion binding]; other site 331678003501 carboxy-terminal protease; Provisional; Region: PRK11186 331678003502 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331678003503 protein binding site [polypeptide binding]; other site 331678003504 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331678003505 Catalytic dyad [active] 331678003506 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 331678003507 argininosuccinate lyase; Provisional; Region: PRK00855 331678003508 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 331678003509 active sites [active] 331678003510 tetramer interface [polypeptide binding]; other site 331678003511 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331678003512 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 331678003513 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 331678003514 ANP binding site [chemical binding]; other site 331678003515 Substrate Binding Site II [chemical binding]; other site 331678003516 Substrate Binding Site I [chemical binding]; other site 331678003517 Arginine repressor [Transcription]; Region: ArgR; COG1438 331678003518 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 331678003519 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 331678003520 ornithine carbamoyltransferase; Provisional; Region: PRK00779 331678003521 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331678003522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003523 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 331678003524 feedback inhibition sensing region; other site 331678003525 homohexameric interface [polypeptide binding]; other site 331678003526 nucleotide binding site [chemical binding]; other site 331678003527 N-acetyl-L-glutamate binding site [chemical binding]; other site 331678003528 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 331678003529 heterotetramer interface [polypeptide binding]; other site 331678003530 active site pocket [active] 331678003531 cleavage site 331678003532 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 331678003533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003534 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 331678003535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331678003536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331678003537 metal binding site [ion binding]; metal-binding site 331678003538 active site 331678003539 I-site; other site 331678003540 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678003541 FtsX-like permease family; Region: FtsX; cl15850 331678003542 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678003543 FtsX-like permease family; Region: FtsX; cl15850 331678003544 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331678003545 iron binding site [ion binding]; other site 331678003546 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331678003547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678003548 Coenzyme A binding pocket [chemical binding]; other site 331678003549 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 331678003550 Predicted membrane protein [Function unknown]; Region: COG2119 331678003551 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 331678003552 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 331678003553 Domain of unknown function DUF87; Region: DUF87; pfam01935 331678003554 HerA helicase [Replication, recombination, and repair]; Region: COG0433 331678003555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678003556 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 331678003557 Walker A/P-loop; other site 331678003558 ATP binding site [chemical binding]; other site 331678003559 Q-loop/lid; other site 331678003560 ABC transporter signature motif; other site 331678003561 Walker B; other site 331678003562 D-loop; other site 331678003563 H-loop/switch region; other site 331678003564 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 331678003565 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 331678003566 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678003567 ATP citrate (pro-S)-lyase; Region: PLN02235 331678003568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003569 ATP citrate (pro-S)-lyase; Region: PLN02522 331678003570 CoA-ligase; Region: Ligase_CoA; cl02894 331678003571 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 331678003572 active site 331678003573 oxalacetate binding site [chemical binding]; other site 331678003574 citrylCoA binding site [chemical binding]; other site 331678003575 coenzyme A binding site [chemical binding]; other site 331678003576 catalytic triad [active] 331678003577 Integrase core domain; Region: rve; cl01316 331678003578 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 331678003579 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 331678003580 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 331678003581 putative active site [active] 331678003582 putative NTP binding site [chemical binding]; other site 331678003583 putative nucleic acid binding site [nucleotide binding]; other site 331678003584 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 331678003585 Integrase core domain; Region: rve_3; cl15866 331678003586 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 331678003587 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331678003589 PAS fold; Region: PAS_3; pfam08447 331678003590 putative active site [active] 331678003591 heme pocket [chemical binding]; other site 331678003592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 331678003593 Transposase domain (DUF772); Region: DUF772; cl15789 331678003594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678003595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678003596 Integrase core domain; Region: rve; cl01316 331678003597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678003598 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678003599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678003600 Walker A motif; other site 331678003601 ATP binding site [chemical binding]; other site 331678003602 Walker B motif; other site 331678003603 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 331678003604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678003605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678003606 DNA binding residues [nucleotide binding] 331678003607 Putative zinc-finger; Region: zf-HC2; cl15806 331678003608 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 331678003609 dimer interface [polypeptide binding]; other site 331678003610 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 331678003611 active site clefts [active] 331678003612 zinc binding site [ion binding]; other site 331678003613 dimer interface [polypeptide binding]; other site 331678003614 lipoyl synthase; Provisional; Region: PRK05481 331678003615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 331678003616 FeS/SAM binding site; other site 331678003617 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003618 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003619 NAD(P) binding site [chemical binding]; other site 331678003620 putative active site [active] 331678003621 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 331678003622 classical (c) SDRs; Region: SDR_c; cd05233 331678003623 NAD(P) binding site [chemical binding]; other site 331678003624 active site 331678003625 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 331678003626 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 331678003627 5-oxoprolinase; Region: PLN02666 331678003628 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 331678003629 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 331678003630 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 331678003631 putative active site [active] 331678003632 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003633 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003634 NAD(P) binding site [chemical binding]; other site 331678003635 putative active site [active] 331678003636 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 331678003637 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like4; cd07217 331678003638 active site 331678003639 nucleophile elbow; other site 331678003640 Transposase domain (DUF772); Region: DUF772; cl15789 331678003641 Transposase domain (DUF772); Region: DUF772; cl15789 331678003642 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 331678003643 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 331678003644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003645 FeS/SAM binding site; other site 331678003646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003647 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 331678003648 FeS/SAM binding site; other site 331678003649 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 331678003650 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 331678003651 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 331678003652 metal binding site [ion binding]; metal-binding site 331678003653 dimer interface [polypeptide binding]; other site 331678003654 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 331678003655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678003656 dimerization interface [polypeptide binding]; other site 331678003657 putative DNA binding site [nucleotide binding]; other site 331678003658 putative Zn2+ binding site [ion binding]; other site 331678003659 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 331678003660 RNA/DNA binding site [nucleotide binding]; other site 331678003661 RRM dimerization site [polypeptide binding]; other site 331678003662 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 331678003663 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331678003664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003665 NAD(P) binding site [chemical binding]; other site 331678003666 active site 331678003667 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 331678003668 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 331678003669 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003670 FeS/SAM binding site; other site 331678003671 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 331678003672 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 331678003673 AMP-binding enzyme; Region: AMP-binding; cl15778 331678003674 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331678003675 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 331678003676 xanthine permease; Region: pbuX; TIGR03173 331678003677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 331678003678 Cache domain; Region: Cache_2; cl07034 331678003679 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 331678003680 putative active site [active] 331678003681 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331678003682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 331678003683 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331678003684 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 331678003685 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 331678003686 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331678003687 minor groove reading motif; other site 331678003688 helix-hairpin-helix signature motif; other site 331678003689 substrate binding pocket [chemical binding]; other site 331678003690 active site 331678003691 Peptidase family M48; Region: Peptidase_M48; cl12018 331678003692 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003693 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003694 NAD(P) binding site [chemical binding]; other site 331678003695 putative active site [active] 331678003696 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 331678003697 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 331678003698 Zn binding site [ion binding]; other site 331678003699 Protein of unknown function, DUF399; Region: DUF399; cl01139 331678003700 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 331678003701 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 331678003702 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 331678003703 additional DNA contacts [nucleotide binding]; other site 331678003704 mismatch recognition site; other site 331678003705 active site 331678003706 zinc binding site [ion binding]; other site 331678003707 DNA intercalation site [nucleotide binding]; other site 331678003708 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 331678003709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 331678003710 cofactor binding site; other site 331678003711 DNA binding site [nucleotide binding] 331678003712 substrate interaction site [chemical binding]; other site 331678003713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 331678003714 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 331678003715 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 331678003716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003717 Restriction endonuclease; Region: Mrr_cat; cl00516 331678003718 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 331678003719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 331678003720 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 331678003721 Family description; Region: UvrD_C_2; cl15862 331678003722 Repair protein; Region: Repair_PSII; cl01535 331678003723 Repair protein; Region: Repair_PSII; cl01535 331678003724 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 331678003725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003726 FeS/SAM binding site; other site 331678003727 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 331678003728 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003729 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003730 NAD(P) binding site [chemical binding]; other site 331678003731 putative active site [active] 331678003732 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678003733 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678003734 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003735 NAD(P) binding site [chemical binding]; other site 331678003736 putative active site [active] 331678003737 Helix-turn-helix domains; Region: HTH; cl00088 331678003738 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456 331678003739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003740 FeS/SAM binding site; other site 331678003741 adenylate kinase; Reviewed; Region: adk; PRK00279 331678003742 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 331678003743 AMP-binding site [chemical binding]; other site 331678003744 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 331678003745 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 331678003746 Helix-turn-helix domains; Region: HTH; cl00088 331678003747 primosome assembly protein PriA; Validated; Region: PRK05580 331678003748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678003749 ATP binding site [chemical binding]; other site 331678003750 putative Mg++ binding site [ion binding]; other site 331678003751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003752 Transposase domain (DUF772); Region: DUF772; cl15789 331678003753 Transposase domain (DUF772); Region: DUF772; cl15789 331678003754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678003755 binding surface 331678003756 TPR motif; other site 331678003757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678003758 TPR motif; other site 331678003759 binding surface 331678003760 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678003761 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 331678003762 trimer interface [polypeptide binding]; other site 331678003763 active site 331678003764 dimer interface [polypeptide binding]; other site 331678003765 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 331678003766 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 331678003767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678003768 Walker A motif; other site 331678003769 ATP binding site [chemical binding]; other site 331678003770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003771 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 331678003772 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 331678003773 active site 331678003774 HslU subunit interaction site [polypeptide binding]; other site 331678003775 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 331678003776 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 331678003777 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 331678003778 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 331678003779 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174 331678003780 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 331678003781 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 331678003782 homodimer interface [polypeptide binding]; other site 331678003783 NADP binding site [chemical binding]; other site 331678003784 substrate binding site [chemical binding]; other site 331678003785 DNA repair protein RadA; Provisional; Region: PRK11823 331678003786 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 331678003787 Walker A motif/ATP binding site; other site 331678003788 ATP binding site [chemical binding]; other site 331678003789 Walker B motif; other site 331678003790 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 331678003791 Membrane protein of unknown function; Region: DUF360; cl00850 331678003792 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331678003793 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 331678003794 putative NAD(P) binding site [chemical binding]; other site 331678003795 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 331678003796 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 331678003797 Walker A/P-loop; other site 331678003798 ATP binding site [chemical binding]; other site 331678003799 Q-loop/lid; other site 331678003800 ABC transporter signature motif; other site 331678003801 Walker B; other site 331678003802 D-loop; other site 331678003803 H-loop/switch region; other site 331678003804 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 331678003805 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 331678003806 TM-ABC transporter signature motif; other site 331678003807 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 331678003808 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 331678003809 Cl- selectivity filter; other site 331678003810 Cl- binding residues [ion binding]; other site 331678003811 pore gating glutamate residue; other site 331678003812 dimer interface [polypeptide binding]; other site 331678003813 FOG: CBS domain [General function prediction only]; Region: COG0517 331678003814 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 331678003815 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 331678003816 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 331678003817 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 331678003818 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 331678003819 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331678003821 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331678003822 substrate binding pocket [chemical binding]; other site 331678003823 chain length determination region; other site 331678003824 substrate-Mg2+ binding site; other site 331678003825 catalytic residues [active] 331678003826 aspartate-rich region 1; other site 331678003827 active site lid residues [active] 331678003828 aspartate-rich region 2; other site 331678003829 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 331678003830 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 331678003831 dephospho-CoA kinase; Provisional; Region: coaE; PRK14731 331678003832 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 331678003833 CoA-binding site [chemical binding]; other site 331678003834 ATP-binding [chemical binding]; other site 331678003835 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 331678003836 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 331678003837 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 331678003838 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 331678003839 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 331678003840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003841 S-adenosylmethionine binding site [chemical binding]; other site 331678003842 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678003843 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 331678003844 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 331678003845 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331678003846 catalytic residues [active] 331678003847 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 331678003848 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 331678003849 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 331678003850 Dicarboxylate transport; Region: DctA-YdbH; cl14674 331678003851 Dicarboxylate transport; Region: DctA-YdbH; cl14674 331678003852 Dicarboxylate transport; Region: DctA-YdbH; cl14674 331678003853 DinB superfamily; Region: DinB_2; pfam12867 331678003854 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 331678003855 flavoprotein, HI0933 family; Region: TIGR00275 331678003856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003857 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678003858 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678003859 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678003860 FtsX-like permease family; Region: FtsX; cl15850 331678003861 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678003862 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 331678003863 Walker A/P-loop; other site 331678003864 ATP binding site [chemical binding]; other site 331678003865 Q-loop/lid; other site 331678003866 ABC transporter signature motif; other site 331678003867 Walker B; other site 331678003868 D-loop; other site 331678003869 H-loop/switch region; other site 331678003870 mercuric reductase; Validated; Region: PRK06370 331678003871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678003872 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331678003873 SET domain; Region: SET; cl02566 331678003874 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 331678003875 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 331678003876 putative active site [active] 331678003877 metal binding site [ion binding]; metal-binding site 331678003878 KWG Leptospira; Region: KWG; pfam07656 331678003879 KWG Leptospira; Region: KWG; pfam07656 331678003880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678003881 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 331678003882 gating phenylalanine in ion channel; other site 331678003883 OsmC-like protein; Region: OsmC; cl00767 331678003884 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 331678003885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678003886 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 331678003887 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 331678003888 putative dimer interface [polypeptide binding]; other site 331678003889 active site pocket [active] 331678003890 putative cataytic base [active] 331678003891 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 331678003892 homotrimer interface [polypeptide binding]; other site 331678003893 Walker A motif; other site 331678003894 GTP binding site [chemical binding]; other site 331678003895 Walker B motif; other site 331678003896 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 331678003897 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 331678003898 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 331678003899 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331678003900 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678003901 DinB superfamily; Region: DinB_2; pfam12867 331678003902 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 331678003903 Sel1 repeat; Region: Sel1; cl02723 331678003904 Sel1 repeat; Region: Sel1; cl02723 331678003905 Sel1 repeat; Region: Sel1; cl02723 331678003906 Sel1 repeat; Region: Sel1; cl02723 331678003907 Sel1 repeat; Region: Sel1; cl02723 331678003908 Sel1 repeat; Region: Sel1; cl02723 331678003909 Sel1 repeat; Region: Sel1; cl02723 331678003910 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331678003911 Sel1 repeat; Region: Sel1; cl02723 331678003912 Sel1 repeat; Region: Sel1; cl02723 331678003913 UbiA prenyltransferase family; Region: UbiA; cl00337 331678003914 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678003915 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 331678003916 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 331678003917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331678003918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003919 S-adenosylmethionine binding site [chemical binding]; other site 331678003920 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 331678003921 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 331678003922 NADP binding site [chemical binding]; other site 331678003923 dimer interface [polypeptide binding]; other site 331678003924 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 331678003925 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 331678003926 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 331678003927 Walker A/P-loop; other site 331678003928 ATP binding site [chemical binding]; other site 331678003929 Q-loop/lid; other site 331678003930 ABC transporter signature motif; other site 331678003931 Walker B; other site 331678003932 D-loop; other site 331678003933 H-loop/switch region; other site 331678003934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331678003935 dimer interface [polypeptide binding]; other site 331678003936 putative PBP binding regions; other site 331678003937 ABC-ATPase subunit interface; other site 331678003938 CobD/Cbib protein; Region: CobD_Cbib; cl00561 331678003939 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 331678003940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678003941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678003942 homodimer interface [polypeptide binding]; other site 331678003943 catalytic residue [active] 331678003944 cobyric acid synthase; Provisional; Region: PRK00784 331678003945 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678003947 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 331678003948 catalytic triad [active] 331678003949 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 331678003950 putative FMN binding site [chemical binding]; other site 331678003951 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 331678003952 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 331678003953 intersubunit interface [polypeptide binding]; other site 331678003954 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 331678003955 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678003956 N-terminal plug; other site 331678003957 ligand-binding site [chemical binding]; other site 331678003958 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 331678003959 putative hydrophobic ligand binding site [chemical binding]; other site 331678003960 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003961 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 331678003962 nudix motif; other site 331678003963 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 331678003964 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 331678003965 cobalamin binding residues [chemical binding]; other site 331678003966 putative BtuC binding residues; other site 331678003967 dimer interface [polypeptide binding]; other site 331678003968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678003969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678003970 putative substrate translocation pore; other site 331678003971 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 331678003972 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 331678003973 active site 331678003974 NTP binding site [chemical binding]; other site 331678003975 metal binding triad [ion binding]; metal-binding site 331678003976 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 331678003977 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678003978 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678003979 adenylosuccinate lyase; Provisional; Region: PRK07492 331678003980 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 331678003981 tetramer interface [polypeptide binding]; other site 331678003982 active site 331678003983 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 331678003984 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 331678003985 ferredoxin; Validated; Region: PRK07118 331678003986 Putative Fe-S cluster; Region: FeS; pfam04060 331678003987 4Fe-4S binding domain; Region: Fer4; cl02805 331678003988 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 331678003989 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 331678003990 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 331678003991 SLBB domain; Region: SLBB; pfam10531 331678003992 4Fe-4S binding domain; Region: Fer4; cl02805 331678003993 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 331678003994 FMN-binding domain; Region: FMN_bind; cl01081 331678003995 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 331678003996 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 331678003997 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 331678003998 dimer interface [polypeptide binding]; other site 331678003999 substrate binding site [chemical binding]; other site 331678004000 metal binding sites [ion binding]; metal-binding site 331678004001 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 331678004002 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 331678004003 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 331678004004 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678004005 Phytase; Region: Phytase; pfam02333 331678004006 AAA domain; Region: AAA_13; pfam13166 331678004007 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004008 AAA domain; Region: AAA_13; pfam13166 331678004009 Walker A/P-loop; other site 331678004010 ATP binding site [chemical binding]; other site 331678004011 Q-loop/lid; other site 331678004012 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 331678004013 Restriction endonuclease; Region: Mrr_cat; cl00516 331678004014 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678004015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678004016 Walker A motif; other site 331678004017 ATP binding site [chemical binding]; other site 331678004018 Walker B motif; other site 331678004019 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331678004020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678004021 active site 331678004022 phosphorylation site [posttranslational modification] 331678004023 intermolecular recognition site; other site 331678004024 dimerization interface [polypeptide binding]; other site 331678004025 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 331678004026 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 331678004027 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 331678004028 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 331678004029 thiS-thiF/thiG interaction site; other site 331678004030 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 331678004031 ThiS interaction site; other site 331678004032 putative active site [active] 331678004033 tetramer interface [polypeptide binding]; other site 331678004034 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 331678004035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678004036 FeS/SAM binding site; other site 331678004037 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 331678004038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331678004039 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 331678004040 Family description; Region: UvrD_C_2; cl15862 331678004041 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 331678004042 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 331678004043 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 331678004044 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 331678004045 Helix-turn-helix domains; Region: HTH; cl00088 331678004046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678004047 S-adenosylmethionine binding site [chemical binding]; other site 331678004048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678004049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678004050 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 331678004051 homodimer interface [polypeptide binding]; other site 331678004052 substrate-cofactor binding pocket; other site 331678004053 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 331678004054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678004055 catalytic residue [active] 331678004056 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 331678004057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004058 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 331678004059 L-serine binding site [chemical binding]; other site 331678004060 ACT domain interface; other site 331678004061 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 331678004062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678004063 motif II; other site 331678004064 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678004065 Putative addiction module component; Region: Unstab_antitox; cl09921 331678004066 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 331678004067 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 331678004068 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 331678004069 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 331678004070 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331678004071 metal-binding site [ion binding] 331678004072 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331678004073 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678004074 FixH; Region: FixH; cl01254 331678004075 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678004076 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 331678004077 4Fe-4S binding domain; Region: Fer4_5; pfam12801 331678004078 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 331678004079 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 331678004080 Cytochrome c; Region: Cytochrom_C; cl11414 331678004081 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 331678004082 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 331678004083 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 331678004084 Low-spin heme binding site [chemical binding]; other site 331678004085 D-pathway; other site 331678004086 Putative water exit pathway; other site 331678004087 Binuclear center (active site) [active] 331678004088 K-pathway; other site 331678004089 Putative proton exit pathway; other site 331678004090 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 331678004091 active site 331678004092 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 331678004093 homodecamer interface [polypeptide binding]; other site 331678004094 GTP cyclohydrolase I; Provisional; Region: PLN03044 331678004095 active site 331678004096 putative catalytic site residues [active] 331678004097 zinc binding site [ion binding]; other site 331678004098 GTP-CH-I/GFRP interaction surface; other site 331678004099 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 331678004100 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 331678004101 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 331678004102 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 331678004103 putative substrate-binding site; other site 331678004104 nickel binding site [ion binding]; other site 331678004105 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 331678004106 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 331678004107 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 331678004108 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 331678004109 Domain of unknown function DUF21; Region: DUF21; pfam01595 331678004110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331678004111 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 331678004112 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 331678004113 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 331678004114 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 331678004115 hydrogenase 4 subunit D; Validated; Region: PRK06525 331678004116 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 331678004117 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 331678004118 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 331678004119 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 331678004120 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 331678004121 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 331678004122 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 331678004123 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004124 NADH dehydrogenase; Region: NADHdh; cl00469 331678004125 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 331678004126 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 331678004127 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 331678004128 NADH dehydrogenase subunit B; Provisional; Region: PRK14813 331678004129 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 331678004130 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 331678004131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004132 TPR motif; other site 331678004133 TPR repeat; Region: TPR_11; pfam13414 331678004134 binding surface 331678004135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004136 binding surface 331678004137 TPR repeat; Region: TPR_11; pfam13414 331678004138 TPR motif; other site 331678004139 TPR repeat; Region: TPR_11; pfam13414 331678004140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004141 binding surface 331678004142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331678004143 TPR motif; other site 331678004144 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 331678004145 nucleotide binding site/active site [active] 331678004146 HIT family signature motif; other site 331678004147 catalytic residue [active] 331678004148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678004149 S-adenosylmethionine binding site [chemical binding]; other site 331678004150 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678004151 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331678004152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004153 universal stress protein UspE; Provisional; Region: PRK11175 331678004154 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678004155 Ligand Binding Site [chemical binding]; other site 331678004156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678004157 Ligand Binding Site [chemical binding]; other site 331678004158 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 331678004159 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 331678004160 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331678004161 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 331678004162 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678004163 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 331678004164 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 331678004165 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 331678004166 recombination factor protein RarA; Reviewed; Region: PRK13342 331678004167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678004168 Walker A motif; other site 331678004169 ATP binding site [chemical binding]; other site 331678004170 Walker B motif; other site 331678004171 arginine finger; other site 331678004172 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 331678004173 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 331678004174 Lumazine binding domain; Region: Lum_binding; pfam00677 331678004175 Lumazine binding domain; Region: Lum_binding; pfam00677 331678004176 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 331678004177 dimer interface [polypeptide binding]; other site 331678004178 catalytic triad [active] 331678004179 peroxidatic and resolving cysteines [active] 331678004180 DoxX; Region: DoxX; cl00976 331678004181 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331678004182 trimer interface [polypeptide binding]; other site 331678004183 eyelet of channel; other site 331678004184 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 331678004185 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 331678004186 catalytic motif [active] 331678004187 Zn binding site [ion binding]; other site 331678004188 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 331678004189 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 331678004190 catalytic motif [active] 331678004191 Zn binding site [ion binding]; other site 331678004192 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 331678004193 Domain of unknown function (DUF814); Region: DUF814; pfam05670 331678004194 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 331678004195 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 331678004196 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 331678004197 Preprotein translocase SecG subunit; Region: SecG; cl09123 331678004198 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 331678004199 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 331678004200 putative active site pocket [active] 331678004201 4-fold oligomerization interface [polypeptide binding]; other site 331678004202 metal binding residues [ion binding]; metal-binding site 331678004203 3-fold/trimer interface [polypeptide binding]; other site 331678004204 phosphodiesterase; Provisional; Region: PRK12704 331678004205 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 331678004206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678004207 Cell division protein ZapA; Region: ZapA; cl01146 331678004208 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 331678004209 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 331678004210 putative tRNA-binding site [nucleotide binding]; other site 331678004211 B3/4 domain; Region: B3_4; cl11458 331678004212 tRNA synthetase B5 domain; Region: B5; cl08394 331678004213 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 331678004214 dimer interface [polypeptide binding]; other site 331678004215 motif 1; other site 331678004216 motif 3; other site 331678004217 motif 2; other site 331678004218 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 331678004219 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331678004220 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678004221 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678004222 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678004223 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331678004224 Helix-turn-helix domains; Region: HTH; cl00088 331678004225 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 331678004226 nudix motif; other site 331678004227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678004228 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 331678004229 active site 331678004230 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 331678004231 putative trimer interface [polypeptide binding]; other site 331678004232 putative CoA binding site [chemical binding]; other site 331678004233 S-adenosylmethionine synthetase; Validated; Region: PRK05250 331678004234 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 331678004235 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 331678004236 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 331678004237 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 331678004238 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 331678004239 oligomerization interface [polypeptide binding]; other site 331678004240 active site 331678004241 NAD+ binding site [chemical binding]; other site 331678004242 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 331678004243 active site 331678004244 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678004245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678004246 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331678004247 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 331678004248 active site 331678004249 Rubrerythrin [Energy production and conversion]; Region: COG1592 331678004250 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 331678004251 binuclear metal center [ion binding]; other site 331678004252 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 331678004253 iron binding site [ion binding]; other site 331678004254 cyclase homology domain; Region: CHD; cd07302 331678004255 nucleotidyl binding site; other site 331678004256 metal binding site [ion binding]; metal-binding site 331678004257 dimer interface [polypeptide binding]; other site 331678004258 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331678004259 Helix-turn-helix domains; Region: HTH; cl00088 331678004260 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 331678004261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678004262 FeS/SAM binding site; other site 331678004263 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 331678004264 Sodium:solute symporter family; Region: SSF; cl00456 331678004265 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 331678004266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678004267 Coenzyme A binding pocket [chemical binding]; other site 331678004268 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678004269 putative efflux protein, MATE family; Region: matE; TIGR00797 331678004270 MatE; Region: MatE; cl10513 331678004271 MatE; Region: MatE; cl10513 331678004272 Helix-turn-helix domains; Region: HTH; cl00088 331678004273 DoxX; Region: DoxX; cl00976 331678004274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678004275 active site residue [active] 331678004276 Domain of unknown function (DUF296); Region: DUF296; cl00720 331678004277 Protein of unknown function DUF45; Region: DUF45; cl00636 331678004278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678004279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678004280 putative substrate translocation pore; other site 331678004281 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 331678004282 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678004283 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678004284 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39_likeD; cd02421 331678004285 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 331678004286 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678004287 ABC-type bacteriocin exporters. Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two...; Region: ABCC_bacteriocin_exporters; cd03245 331678004288 Walker A/P-loop; other site 331678004289 ATP binding site [chemical binding]; other site 331678004290 Q-loop/lid; other site 331678004291 ABC transporter signature motif; other site 331678004292 Walker B; other site 331678004293 D-loop; other site 331678004294 H-loop/switch region; other site 331678004295 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331678004296 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 331678004297 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 331678004298 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 331678004299 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331678004300 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678004301 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 331678004302 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 331678004303 DEAD-like helicases superfamily; Region: DEXDc; smart00487 331678004304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004305 putative Mg++ binding site [ion binding]; other site 331678004306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004307 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 331678004308 putative homodimer interface [polypeptide binding]; other site 331678004309 putative active site [active] 331678004310 catalytic site [active] 331678004311 Protein of unknown function (DUF511); Region: DUF511; cl01114 331678004312 Restriction endonuclease; Region: Mrr_cat; cl00516 331678004313 Putative ATP-dependent Lon protease; Region: Lon_2; cl11979 331678004314 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 331678004315 TIGR02687 family protein; Region: TIGR02687 331678004316 PglZ domain; Region: PglZ; pfam08665 331678004317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004318 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 331678004319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004320 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004321 AAA domain; Region: AAA_21; pfam13304 331678004322 Walker A/P-loop; other site 331678004323 ATP binding site [chemical binding]; other site 331678004324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004325 Walker B; other site 331678004326 D-loop; other site 331678004327 H-loop/switch region; other site 331678004328 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 331678004329 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 331678004330 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678004331 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 331678004332 putative active site pocket [active] 331678004333 dimerization interface [polypeptide binding]; other site 331678004334 putative catalytic residue [active] 331678004335 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 331678004336 active site 331678004337 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 331678004338 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 331678004339 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 331678004340 catalytic triad [active] 331678004341 Double zinc ribbon; Region: DZR; pfam12773 331678004342 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 331678004343 nudix motif; other site 331678004344 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 331678004345 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331678004346 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678004347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331678004348 dimerization interface [polypeptide binding]; other site 331678004349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 331678004350 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 331678004351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678004352 dimer interface [polypeptide binding]; other site 331678004353 phosphorylation site [posttranslational modification] 331678004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678004355 ATP binding site [chemical binding]; other site 331678004356 Mg2+ binding site [ion binding]; other site 331678004357 G-X-G motif; other site 331678004358 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 331678004359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678004360 active site 331678004361 phosphorylation site [posttranslational modification] 331678004362 intermolecular recognition site; other site 331678004363 dimerization interface [polypeptide binding]; other site 331678004364 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331678004365 DNA binding site [nucleotide binding] 331678004366 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 331678004367 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 331678004368 Walker A/P-loop; other site 331678004369 ATP binding site [chemical binding]; other site 331678004370 Q-loop/lid; other site 331678004371 ABC transporter signature motif; other site 331678004372 Walker B; other site 331678004373 D-loop; other site 331678004374 H-loop/switch region; other site 331678004375 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331678004376 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 331678004377 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 331678004378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678004379 ATP binding site [chemical binding]; other site 331678004380 putative Mg++ binding site [ion binding]; other site 331678004381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678004382 nucleotide binding region [chemical binding]; other site 331678004383 ATP-binding site [chemical binding]; other site 331678004384 TRCF domain; Region: TRCF; cl04088 331678004385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678004386 catalytic loop [active] 331678004387 iron binding site [ion binding]; other site 331678004388 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 331678004389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 331678004390 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004391 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 331678004392 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 331678004393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004395 carotene isomerase; Region: carot_isom; TIGR02730 331678004396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004397 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 331678004398 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678004399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678004400 DNA binding residues [nucleotide binding] 331678004401 Putative zinc-finger; Region: zf-HC2; cl15806 331678004402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678004403 dimerization interface [polypeptide binding]; other site 331678004404 putative DNA binding site [nucleotide binding]; other site 331678004405 putative Zn2+ binding site [ion binding]; other site 331678004406 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331678004407 putative dimer interface [polypeptide binding]; other site 331678004408 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 331678004409 Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657 331678004410 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 331678004411 Tetratricopeptide repeat; Region: TPR_6; pfam13174 331678004412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331678004413 ligand binding site [chemical binding]; other site 331678004414 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 331678004415 TolB amino-terminal domain; Region: TolB_N; cl00639 331678004416 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331678004417 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331678004418 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331678004419 Gram-negative bacterial tonB protein; Region: TonB; cl10048 331678004420 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 331678004421 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 331678004422 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 331678004423 Integral membrane protein DUF92; Region: DUF92; cl00793 331678004424 Dehydratase family; Region: ILVD_EDD; cl00340 331678004425 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 331678004426 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331678004427 PYR/PP interface [polypeptide binding]; other site 331678004428 dimer interface [polypeptide binding]; other site 331678004429 TPP binding site [chemical binding]; other site 331678004430 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 331678004431 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 331678004432 TPP-binding site [chemical binding]; other site 331678004433 dimer interface [polypeptide binding]; other site 331678004434 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 331678004435 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 331678004436 putative valine binding site [chemical binding]; other site 331678004437 dimer interface [polypeptide binding]; other site 331678004438 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 331678004439 ketol-acid reductoisomerase; Provisional; Region: PRK05479 331678004440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004441 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 331678004442 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 331678004443 tartrate dehydrogenase; Provisional; Region: PRK08194 331678004444 2-isopropylmalate synthase; Validated; Region: PRK00915 331678004445 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 331678004446 active site 331678004447 catalytic residues [active] 331678004448 metal binding site [ion binding]; metal-binding site 331678004449 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 331678004450 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 331678004451 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 331678004452 substrate binding site [chemical binding]; other site 331678004453 ligand binding site [chemical binding]; other site 331678004454 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 331678004455 substrate binding site [chemical binding]; other site 331678004456 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 331678004457 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 331678004458 active site 331678004459 catalytic residues [active] 331678004460 metal binding site [ion binding]; metal-binding site 331678004461 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 331678004462 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 331678004463 serpin-like protein; Provisional; Region: PHA02660 331678004464 reactive center loop; other site 331678004465 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678004466 active site 331678004467 substrate binding site [chemical binding]; other site 331678004468 catalytic site [active] 331678004469 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 331678004470 agmatine deiminase; Region: agmatine_aguA; TIGR03380 331678004471 Peptidase family M48; Region: Peptidase_M48; cl12018 331678004472 Yeast cortical protein KAR9; Region: KAR9; pfam08580 331678004473 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 331678004474 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 331678004475 N-carbamolyputrescine amidase; Region: PLN02747 331678004476 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 331678004477 putative active site; other site 331678004478 catalytic triad [active] 331678004479 putative dimer interface [polypeptide binding]; other site 331678004480 UbiA prenyltransferase family; Region: UbiA; cl00337 331678004481 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 331678004482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678004484 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 331678004485 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 331678004486 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 331678004487 substrate binding site [chemical binding]; other site 331678004488 glutamase interaction surface [polypeptide binding]; other site 331678004489 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 331678004490 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 331678004491 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678004492 iron-sulfur cluster [ion binding]; other site 331678004493 [2Fe-2S] cluster binding site [ion binding]; other site 331678004494 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 331678004495 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 331678004496 Domain of unknown function (DUF389); Region: DUF389; cl00781 331678004497 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 331678004498 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 331678004499 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 331678004500 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 331678004501 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 331678004502 active site 331678004503 purine riboside binding site [chemical binding]; other site 331678004504 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678004505 active site 331678004506 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 331678004507 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 331678004508 active site 331678004509 catalytic residues [active] 331678004510 metal binding site [ion binding]; metal-binding site 331678004511 Nif-specific regulatory protein; Region: nifA; TIGR01817 331678004512 GAF domain; Region: GAF; cl15785 331678004513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678004514 Walker A motif; other site 331678004515 ATP binding site [chemical binding]; other site 331678004516 Walker B motif; other site 331678004517 arginine finger; other site 331678004518 Helix-turn-helix domains; Region: HTH; cl00088 331678004519 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 331678004520 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 331678004521 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 331678004522 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 331678004523 Nucleotide-binding sites [chemical binding]; other site 331678004524 Walker A motif; other site 331678004525 Switch I region of nucleotide binding site; other site 331678004526 Fe4S4 binding sites [ion binding]; other site 331678004527 Switch II region of nucleotide binding site; other site 331678004528 Nitrogen regulatory protein P-II; Region: P-II; cl00412 331678004529 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678004530 Nitrogen regulatory protein P-II; Region: P-II; cl00412 331678004531 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678004532 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 331678004533 MoFe protein alpha/beta subunit interactions; other site 331678004534 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 331678004535 Alpha subunit P cluster binding residues; other site 331678004536 FeMoco binding residues [chemical binding]; other site 331678004537 MoFe protein alpha subunit/Fe protein contacts; other site 331678004538 MoFe protein dimer/ dimer interactions; other site 331678004539 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 331678004540 MoFe protein beta/alpha subunit interactions; other site 331678004541 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 331678004542 Beta subunit P cluster binding residues; other site 331678004543 MoFe protein beta subunit/Fe protein contacts; other site 331678004544 MoFe protein dimer/ dimer interactions; other site 331678004545 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 331678004546 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 331678004547 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 331678004548 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 331678004549 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 331678004550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678004551 FeS/SAM binding site; other site 331678004552 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 331678004553 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 331678004554 dimer interface [polypeptide binding]; other site 331678004555 [2Fe-2S] cluster binding site [ion binding]; other site 331678004556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678004557 dimer interface [polypeptide binding]; other site 331678004558 phosphorylation site [posttranslational modification] 331678004559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678004560 ATP binding site [chemical binding]; other site 331678004561 Mg2+ binding site [ion binding]; other site 331678004562 G-X-G motif; other site 331678004563 Response regulator receiver domain; Region: Response_reg; pfam00072 331678004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678004565 active site 331678004566 phosphorylation site [posttranslational modification] 331678004567 intermolecular recognition site; other site 331678004568 dimerization interface [polypeptide binding]; other site 331678004569 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 331678004570 dimerization interface [polypeptide binding]; other site 331678004571 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 331678004572 ATP binding site [chemical binding]; other site 331678004573 Hydrogenase formation hypA family; Region: HypD; cl12072 331678004574 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 331678004575 HupF/HypC family; Region: HupF_HypC; cl00394 331678004576 Acylphosphatase; Region: Acylphosphatase; cl00551 331678004577 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 331678004578 HypF finger; Region: zf-HYPF; pfam07503 331678004579 HypF finger; Region: zf-HYPF; pfam07503 331678004580 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 331678004581 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004582 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 331678004583 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 331678004584 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 331678004585 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331678004586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004587 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 331678004588 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 331678004589 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 331678004590 Sodium:solute symporter family; Region: SSF; cl00456 331678004591 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 331678004592 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 331678004593 GIY-YIG motif/motif A; other site 331678004594 active site 331678004595 catalytic site [active] 331678004596 putative DNA binding site [nucleotide binding]; other site 331678004597 metal binding site [ion binding]; metal-binding site 331678004598 UvrB/uvrC motif; Region: UVR; pfam02151 331678004599 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 331678004600 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 331678004601 DNA binding site [nucleotide binding] 331678004602 TPR repeat; Region: TPR_11; pfam13414 331678004603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004604 binding surface 331678004605 TPR motif; other site 331678004606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004607 binding surface 331678004608 TPR repeat; Region: TPR_11; pfam13414 331678004609 TPR motif; other site 331678004610 TPR repeat; Region: TPR_11; pfam13414 331678004611 TPR repeat; Region: TPR_11; pfam13414 331678004612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004613 binding surface 331678004614 TPR motif; other site 331678004615 TPR repeat; Region: TPR_11; pfam13414 331678004616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004617 binding surface 331678004618 TPR motif; other site 331678004619 TPR repeat; Region: TPR_11; pfam13414 331678004620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004621 binding surface 331678004622 TPR motif; other site 331678004623 TPR repeat; Region: TPR_11; pfam13414 331678004624 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 331678004625 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 331678004626 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 331678004627 shikimate binding site; other site 331678004628 NAD(P) binding site [chemical binding]; other site 331678004629 lipoprotein signal peptidase; Provisional; Region: PRK14787 331678004630 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 331678004631 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 331678004632 active site 331678004633 Tetratricopeptide repeat; Region: TPR_12; pfam13424 331678004634 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 331678004635 active site 331678004636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 331678004637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331678004638 catalytic residue [active] 331678004639 alanine aminotransferase; Validated; Region: PRK08363 331678004640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678004641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678004642 homodimer interface [polypeptide binding]; other site 331678004643 catalytic residue [active] 331678004644 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 331678004645 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 331678004646 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 331678004647 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 331678004648 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 331678004649 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678004650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004651 Walker A/P-loop; other site 331678004652 ATP binding site [chemical binding]; other site 331678004653 Q-loop/lid; other site 331678004654 ABC transporter signature motif; other site 331678004655 Walker B; other site 331678004656 D-loop; other site 331678004657 H-loop/switch region; other site 331678004658 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 331678004659 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678004660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004661 Walker A/P-loop; other site 331678004662 ATP binding site [chemical binding]; other site 331678004663 Q-loop/lid; other site 331678004664 ABC transporter signature motif; other site 331678004665 Walker B; other site 331678004666 D-loop; other site 331678004667 H-loop/switch region; other site 331678004668 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 331678004669 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 331678004670 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 331678004671 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 331678004672 putative active site [active] 331678004673 putative substrate binding site [chemical binding]; other site 331678004674 putative cosubstrate binding site; other site 331678004675 catalytic site [active] 331678004676 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 331678004677 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 331678004678 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 331678004679 active site 331678004680 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 331678004681 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 331678004682 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331678004683 Ligand binding site; other site 331678004684 Putative Catalytic site; other site 331678004685 DXD motif; other site 331678004686 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 331678004687 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 331678004688 DHH family; Region: DHH; pfam01368 331678004689 DHHA1 domain; Region: DHHA1; pfam02272 331678004690 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 331678004691 AMP binding site [chemical binding]; other site 331678004692 metal binding site [ion binding]; metal-binding site 331678004693 active site 331678004694 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678004695 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 331678004696 putative active site [active] 331678004697 metal binding site [ion binding]; metal-binding site 331678004698 homodimer binding site [polypeptide binding]; other site 331678004699 Pirin-related protein [General function prediction only]; Region: COG1741 331678004700 Cupin domain; Region: Cupin_2; cl09118 331678004701 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 331678004702 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 331678004703 Quinolinate synthetase A protein; Region: NadA; cl00420 331678004704 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331678004705 oligomerisation interface [polypeptide binding]; other site 331678004706 mobile loop; other site 331678004707 roof hairpin; other site 331678004708 Cation efflux family; Region: Cation_efflux; cl00316 331678004709 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 331678004710 rod shape-determining protein MreC; Provisional; Region: PRK13922 331678004711 rod shape-determining protein MreC; Region: MreC; pfam04085 331678004712 rod shape-determining protein MreD; Region: MreD; cl01087 331678004713 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 331678004714 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331678004715 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 331678004716 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331678004717 FAD binding domain; Region: FAD_binding_4; pfam01565 331678004718 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 331678004719 SmpB-tmRNA interface; other site 331678004720 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 331678004721 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 331678004722 active site 331678004723 HIGH motif; other site 331678004724 dimer interface [polypeptide binding]; other site 331678004725 KMSKS motif; other site 331678004726 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 331678004727 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 331678004728 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 331678004729 Domain of unknown function (DUF368); Region: DUF368; cl00893 331678004730 L-aspartate oxidase; Provisional; Region: PRK09077 331678004731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004732 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678004733 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 331678004734 homodimer interface [polypeptide binding]; other site 331678004735 NAD synthase; Region: NAD_synthase; pfam02540 331678004736 NAD binding pocket [chemical binding]; other site 331678004737 ATP binding pocket [chemical binding]; other site 331678004738 Mg binding site [ion binding]; other site 331678004739 active-site loop [active] 331678004740 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 331678004741 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 331678004742 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 331678004743 hinge; other site 331678004744 active site 331678004745 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 331678004746 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 331678004747 substrate binding site [chemical binding]; other site 331678004748 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 331678004749 substrate binding site [chemical binding]; other site 331678004750 ligand binding site [chemical binding]; other site 331678004751 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 331678004752 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 331678004753 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 331678004754 histidinol dehydrogenase; Region: hisD; TIGR00069 331678004755 NAD binding site [chemical binding]; other site 331678004756 dimerization interface [polypeptide binding]; other site 331678004757 product binding site; other site 331678004758 substrate binding site [chemical binding]; other site 331678004759 zinc binding site [ion binding]; other site 331678004760 catalytic residues [active] 331678004761 rod shape-determining protein MreB; Provisional; Region: PRK13930 331678004762 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 331678004763 ATP binding site [chemical binding]; other site 331678004764 gelsolin binding site; other site 331678004765 profilin binding site; other site 331678004766 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 331678004767 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 331678004768 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941 331678004769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678004770 putative substrate translocation pore; other site 331678004771 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 331678004772 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 331678004773 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 331678004774 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 331678004775 TPP-binding site; other site 331678004776 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331678004777 PYR/PP interface [polypeptide binding]; other site 331678004778 dimer interface [polypeptide binding]; other site 331678004779 TPP binding site [chemical binding]; other site 331678004780 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331678004781 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 331678004782 tetramer interfaces [polypeptide binding]; other site 331678004783 binuclear metal-binding site [ion binding]; other site 331678004784 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 331678004785 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 331678004786 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 331678004787 Walker A/P-loop; other site 331678004788 ATP binding site [chemical binding]; other site 331678004789 Q-loop/lid; other site 331678004790 ABC transporter signature motif; other site 331678004791 Walker B; other site 331678004792 D-loop; other site 331678004793 H-loop/switch region; other site 331678004794 Smr domain; Region: Smr; cl02619 331678004795 DsrE/DsrF-like family; Region: DrsE; cl00672 331678004796 Flagellin N-methylase; Region: FliB; cl00497 331678004797 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004798 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 331678004799 tricarballylate utilization protein B; Provisional; Region: PRK15033 331678004800 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 331678004801 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 331678004802 4Fe-4S binding domain; Region: Fer4; cl02805 331678004803 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 331678004804 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 331678004805 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678004806 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 331678004807 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 331678004808 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 331678004809 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 331678004810 ATP-sulfurylase; Region: ATPS; cd00517 331678004811 active site 331678004812 HXXH motif; other site 331678004813 flexible loop; other site 331678004814 DsrE/DsrF-like family; Region: DrsE; cl00672 331678004815 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 331678004816 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 331678004817 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 331678004818 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 331678004819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004820 Polysulphide reductase, NrfD; Region: NrfD; cl01295 331678004821 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 331678004822 4Fe-4S binding domain; Region: Fer4; cl02805 331678004823 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331678004824 Cysteine-rich domain; Region: CCG; pfam02754 331678004825 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 331678004826 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 331678004827 DsrE/DsrF-like family; Region: DrsE; cl00672 331678004828 DsrE/DsrF-like family; Region: DrsE; cl00672 331678004829 DsrE/DsrF-like family; Region: DrsE; cl00672 331678004830 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 331678004831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004832 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004833 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 331678004834 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331678004835 4Fe-4S binding domain; Region: Fer4; cl02805 331678004836 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 331678004837 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331678004838 DsrC like protein; Region: DsrC; cl01101 331678004839 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 331678004840 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 331678004841 catalytic triad [active] 331678004842 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 331678004843 CPxP motif; other site 331678004844 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 331678004845 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678004846 active site residue [active] 331678004847 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 331678004848 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678004849 molybdopterin cofactor binding site; other site 331678004850 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678004851 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678004852 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 331678004853 putative molybdopterin cofactor binding site; other site 331678004854 tetrathionate reductase subunit B; Provisional; Region: PRK14993 331678004855 4Fe-4S binding domain; Region: Fer4; cl02805 331678004856 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 331678004857 Polysulphide reductase, NrfD; Region: NrfD; cl01295 331678004858 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 331678004859 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 331678004860 active site 331678004861 hydrophilic channel; other site 331678004862 dimerization interface [polypeptide binding]; other site 331678004863 catalytic residues [active] 331678004864 active site lid [active] 331678004865 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 331678004866 active site 331678004867 dimerization interface [polypeptide binding]; other site 331678004868 Bacitracin resistance protein BacA; Region: BacA; cl00858 331678004869 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 331678004870 Permease; Region: Permease; cl00510 331678004871 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 331678004872 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 331678004873 Walker A/P-loop; other site 331678004874 ATP binding site [chemical binding]; other site 331678004875 Q-loop/lid; other site 331678004876 ABC transporter signature motif; other site 331678004877 Walker B; other site 331678004878 D-loop; other site 331678004879 H-loop/switch region; other site 331678004880 mce related protein; Region: MCE; pfam02470 331678004881 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 331678004882 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 331678004883 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 331678004884 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 331678004885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678004887 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678004888 iron-sulfur cluster [ion binding]; other site 331678004889 [2Fe-2S] cluster binding site [ion binding]; other site 331678004890 Uncharacterized conserved protein [Function unknown]; Region: COG3349 331678004891 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 331678004892 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 331678004893 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 331678004894 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 331678004895 purine monophosphate binding site [chemical binding]; other site 331678004896 dimer interface [polypeptide binding]; other site 331678004897 putative catalytic residues [active] 331678004898 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 331678004899 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 331678004900 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 331678004901 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 331678004902 active site 331678004903 substrate binding site [chemical binding]; other site 331678004904 cosubstrate binding site; other site 331678004905 catalytic site [active] 331678004906 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 331678004907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 331678004908 FeS/SAM binding site; other site 331678004909 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 331678004910 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331678004911 Ligand binding site; other site 331678004912 Putative Catalytic site; other site 331678004913 DXD motif; other site 331678004914 endonuclease IV; Provisional; Region: PRK01060 331678004915 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 331678004916 AP (apurinic/apyrimidinic) site pocket; other site 331678004917 DNA interaction; other site 331678004918 Metal-binding active site; metal-binding site 331678004919 FtsX-like permease family; Region: FtsX; cl15850 331678004920 amidophosphoribosyltransferase; Provisional; Region: PRK09123 331678004921 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 331678004922 active site 331678004923 tetramer interface [polypeptide binding]; other site 331678004924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678004925 active site 331678004926 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 331678004927 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 331678004928 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678004929 active site 331678004930 HIGH motif; other site 331678004931 nucleotide binding site [chemical binding]; other site 331678004932 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678004933 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678004934 active site 331678004935 KMSKS motif; other site 331678004936 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 331678004937 tRNA binding surface [nucleotide binding]; other site 331678004938 anticodon binding site; other site 331678004939 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331678004940 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331678004941 NAD binding site [chemical binding]; other site 331678004942 substrate binding site [chemical binding]; other site 331678004943 homodimer interface [polypeptide binding]; other site 331678004944 active site 331678004945 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678004946 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 331678004947 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 331678004948 NADP binding site [chemical binding]; other site 331678004949 active site 331678004950 putative substrate binding site [chemical binding]; other site 331678004951 Cupin domain; Region: Cupin_2; cl09118 331678004952 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678004953 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331678004954 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331678004955 substrate binding site; other site 331678004956 tetramer interface; other site 331678004957 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 331678004958 active site 331678004959 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331678004960 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331678004961 glutaminase active site [active] 331678004962 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331678004963 dimer interface [polypeptide binding]; other site 331678004964 active site 331678004965 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331678004966 dimer interface [polypeptide binding]; other site 331678004967 active site 331678004968 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 331678004969 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331678004970 Substrate binding site; other site 331678004971 Cupin domain; Region: Cupin_2; cl09118 331678004972 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678004973 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 331678004974 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 331678004975 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 331678004976 active site 331678004977 substrate binding site [chemical binding]; other site 331678004978 metal binding site [ion binding]; metal-binding site 331678004979 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678004980 oligomeric interface; other site 331678004981 putative active site [active] 331678004982 homodimer interface [polypeptide binding]; other site 331678004983 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 331678004984 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678004985 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 331678004986 AAA domain; Region: AAA_33; pfam13671 331678004987 ligand-binding site [chemical binding]; other site 331678004988 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 331678004989 putative active site [active] 331678004990 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331678004991 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331678004992 NAD binding site [chemical binding]; other site 331678004993 substrate binding site [chemical binding]; other site 331678004994 homodimer interface [polypeptide binding]; other site 331678004995 active site 331678004996 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678004997 Cupin domain; Region: Cupin_2; cl09118 331678004998 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331678004999 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331678005000 substrate binding site; other site 331678005001 tetramer interface; other site 331678005002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005003 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678005004 NAD(P) binding site [chemical binding]; other site 331678005005 active site 331678005006 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331678005007 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331678005008 NAD binding site [chemical binding]; other site 331678005009 substrate binding site [chemical binding]; other site 331678005010 homodimer interface [polypeptide binding]; other site 331678005011 active site 331678005012 Cupin domain; Region: Cupin_2; cl09118 331678005013 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331678005014 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331678005015 substrate binding site; other site 331678005016 tetramer interface; other site 331678005017 Transposase domain (DUF772); Region: DUF772; cl15789 331678005018 Transposase domain (DUF772); Region: DUF772; cl15789 331678005019 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 331678005020 Transposase; Region: DDE_Tnp_ISL3; pfam01610 331678005021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678005022 active site 331678005023 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 331678005024 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678005025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678005026 active site 331678005027 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005028 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678005029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005030 FeS/SAM binding site; other site 331678005031 O-Antigen ligase; Region: Wzy_C; cl04850 331678005032 MatE; Region: MatE; cl10513 331678005033 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 331678005034 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 331678005035 inhibitor-cofactor binding pocket; inhibition site 331678005036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678005037 catalytic residue [active] 331678005038 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 331678005039 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 331678005040 NADP binding site [chemical binding]; other site 331678005041 active site 331678005042 putative substrate binding site [chemical binding]; other site 331678005043 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 331678005044 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 331678005045 NADP-binding site; other site 331678005046 homotetramer interface [polypeptide binding]; other site 331678005047 substrate binding site [chemical binding]; other site 331678005048 homodimer interface [polypeptide binding]; other site 331678005049 active site 331678005050 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005051 YcfA-like protein; Region: YcfA; cl00752 331678005052 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 331678005053 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678005054 putative active site [active] 331678005055 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005056 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 331678005057 GIY-YIG motif/motif A; other site 331678005058 putative active site [active] 331678005059 putative metal binding site [ion binding]; other site 331678005060 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 331678005061 YcfA-like protein; Region: YcfA; cl00752 331678005062 Protein of unknown function DUF86; Region: DUF86; cl01031 331678005063 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678005064 active site 331678005065 NTP binding site [chemical binding]; other site 331678005066 metal binding triad [ion binding]; metal-binding site 331678005067 antibiotic binding site [chemical binding]; other site 331678005068 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005069 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 331678005070 YcfA-like protein; Region: YcfA; cl00752 331678005071 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 331678005072 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678005073 putative active site [active] 331678005074 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 331678005075 Protein of unknown function DUF86; Region: DUF86; cl01031 331678005076 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678005077 active site 331678005078 NTP binding site [chemical binding]; other site 331678005079 metal binding triad [ion binding]; metal-binding site 331678005080 antibiotic binding site [chemical binding]; other site 331678005081 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005082 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 331678005083 putative active site [active] 331678005084 homotetrameric interface [polypeptide binding]; other site 331678005085 metal binding site [ion binding]; metal-binding site 331678005086 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 331678005087 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678005088 oligomeric interface; other site 331678005089 putative active site [active] 331678005090 homodimer interface [polypeptide binding]; other site 331678005091 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 331678005092 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005093 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 331678005094 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 331678005095 Protein of unknown function DUF86; Region: DUF86; cl01031 331678005096 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678005097 active site 331678005098 NTP binding site [chemical binding]; other site 331678005099 metal binding triad [ion binding]; metal-binding site 331678005100 antibiotic binding site [chemical binding]; other site 331678005101 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005102 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 331678005103 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 331678005104 Mg++ binding site [ion binding]; other site 331678005105 putative catalytic motif [active] 331678005106 substrate binding site [chemical binding]; other site 331678005107 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 331678005108 Mg++ binding site [ion binding]; other site 331678005109 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 331678005110 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 331678005111 Chain length determinant protein; Region: Wzz; cl15801 331678005112 Chain length determinant protein; Region: Wzz; cl15801 331678005113 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 331678005114 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005115 Nucleotide binding site [chemical binding]; other site 331678005116 DTAP/Switch II; other site 331678005117 Switch I; other site 331678005118 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 331678005119 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 331678005120 active site 331678005121 catalytic site [active] 331678005122 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 331678005123 GIY-YIG motif/motif A; other site 331678005124 putative active site [active] 331678005125 putative metal binding site [ion binding]; other site 331678005126 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 331678005127 intrachain domain interface; other site 331678005128 interchain domain interface [polypeptide binding]; other site 331678005129 heme bH binding site [chemical binding]; other site 331678005130 Qi binding site; other site 331678005131 heme bL binding site [chemical binding]; other site 331678005132 Qo binding site; other site 331678005133 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 331678005134 interchain domain interface [polypeptide binding]; other site 331678005135 intrachain domain interface; other site 331678005136 Qi binding site; other site 331678005137 Qo binding site; other site 331678005138 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 331678005139 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 331678005140 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678005141 iron-sulfur cluster [ion binding]; other site 331678005142 [2Fe-2S] cluster binding site [ion binding]; other site 331678005143 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 331678005144 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 331678005145 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331678005146 HIGH motif; other site 331678005147 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331678005148 active site 331678005149 KMSKS motif; other site 331678005150 CagZ; Region: CagZ; pfam09053 331678005151 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 331678005152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678005153 Walker A motif; other site 331678005154 ATP binding site [chemical binding]; other site 331678005155 Walker B motif; other site 331678005156 arginine finger; other site 331678005157 Peptidase family M41; Region: Peptidase_M41; pfam01434 331678005158 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331678005159 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331678005160 IHF dimer interface [polypeptide binding]; other site 331678005161 IHF - DNA interface [nucleotide binding]; other site 331678005162 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 331678005163 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 331678005164 transmembrane helices; other site 331678005165 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 331678005166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678005167 active site 331678005168 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331678005169 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 331678005170 Intra-flagellar transport protein 57; Region: IFT57; pfam10498 331678005171 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 331678005172 GTPase Era; Reviewed; Region: era; PRK00089 331678005173 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 331678005174 G1 box; other site 331678005175 GTP/Mg2+ binding site [chemical binding]; other site 331678005176 Switch I region; other site 331678005177 G2 box; other site 331678005178 Switch II region; other site 331678005179 G3 box; other site 331678005180 G4 box; other site 331678005181 G5 box; other site 331678005182 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 331678005183 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 331678005184 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 331678005185 RNA binding site [nucleotide binding]; other site 331678005186 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 331678005187 RNA binding site [nucleotide binding]; other site 331678005188 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 331678005189 RNA binding site [nucleotide binding]; other site 331678005190 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678005191 RNA binding site [nucleotide binding]; other site 331678005192 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 331678005193 RNA binding site [nucleotide binding]; other site 331678005194 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 331678005195 RNA binding site [nucleotide binding]; other site 331678005196 GTP-binding protein YchF; Reviewed; Region: PRK09601 331678005197 YchF GTPase; Region: YchF; cd01900 331678005198 G1 box; other site 331678005199 GTP/Mg2+ binding site [chemical binding]; other site 331678005200 Switch I region; other site 331678005201 G2 box; other site 331678005202 Switch II region; other site 331678005203 G3 box; other site 331678005204 G4 box; other site 331678005205 G5 box; other site 331678005206 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 331678005207 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 331678005208 short chain dehydrogenase; Provisional; Region: PRK12829 331678005209 classical (c) SDRs; Region: SDR_c; cd05233 331678005210 NAD(P) binding site [chemical binding]; other site 331678005211 active site 331678005212 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 331678005213 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 331678005214 dimer interface [polypeptide binding]; other site 331678005215 catalytic residue [active] 331678005216 metal binding site [ion binding]; metal-binding site 331678005217 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 331678005218 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 331678005219 putative active site; other site 331678005220 catalytic residue [active] 331678005221 short chain dehydrogenase; Validated; Region: PRK08324 331678005222 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 331678005223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005224 NAD(P) binding site [chemical binding]; other site 331678005225 active site 331678005226 RecX family; Region: RecX; cl00936 331678005227 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 331678005228 putative nucleotide binding site [chemical binding]; other site 331678005229 uridine monophosphate binding site [chemical binding]; other site 331678005230 homohexameric interface [polypeptide binding]; other site 331678005231 elongation factor Ts; Provisional; Region: tsf; PRK09377 331678005232 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 331678005233 Elongation factor TS; Region: EF_TS; pfam00889 331678005234 Elongation factor TS; Region: EF_TS; pfam00889 331678005235 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 331678005236 rRNA interaction site [nucleotide binding]; other site 331678005237 S8 interaction site; other site 331678005238 putative laminin-1 binding site; other site 331678005239 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 331678005240 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 331678005241 23S rRNA interface [nucleotide binding]; other site 331678005242 L3 interface [polypeptide binding]; other site 331678005243 GTP-binding protein Der; Reviewed; Region: PRK00093 331678005244 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 331678005245 G1 box; other site 331678005246 GTP/Mg2+ binding site [chemical binding]; other site 331678005247 Switch I region; other site 331678005248 G2 box; other site 331678005249 Switch II region; other site 331678005250 G3 box; other site 331678005251 G4 box; other site 331678005252 G5 box; other site 331678005253 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 331678005254 G1 box; other site 331678005255 GTP/Mg2+ binding site [chemical binding]; other site 331678005256 Switch I region; other site 331678005257 G2 box; other site 331678005258 G3 box; other site 331678005259 Switch II region; other site 331678005260 G4 box; other site 331678005261 G5 box; other site 331678005262 antiporter inner membrane protein; Provisional; Region: PRK11670 331678005263 Domain of unknown function DUF59; Region: DUF59; cl00941 331678005264 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 331678005265 Walker A motif; other site 331678005266 NifU-like domain; Region: NifU; cl00484 331678005267 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 331678005268 DNA translocase FtsK; Provisional; Region: PRK10263 331678005269 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678005270 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 331678005271 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 331678005272 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 331678005273 TPR repeat; Region: TPR_11; pfam13414 331678005274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678005275 binding surface 331678005276 TPR motif; other site 331678005277 TPR repeat; Region: TPR_11; pfam13414 331678005278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 331678005279 Repair protein; Region: Repair_PSII; cl01535 331678005280 Repair protein; Region: Repair_PSII; cl01535 331678005281 LemA family; Region: LemA; cl00742 331678005282 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 331678005283 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 331678005284 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 331678005285 synthetase active site [active] 331678005286 NTP binding site [chemical binding]; other site 331678005287 metal binding site [ion binding]; metal-binding site 331678005288 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 331678005289 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 331678005290 excinuclease ABC subunit B; Provisional; Region: PRK05298 331678005291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678005292 ATP binding site [chemical binding]; other site 331678005293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678005294 nucleotide binding region [chemical binding]; other site 331678005295 ATP-binding site [chemical binding]; other site 331678005296 Ultra-violet resistance protein B; Region: UvrB; pfam12344 331678005297 UvrB/uvrC motif; Region: UVR; pfam02151 331678005298 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 331678005299 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331678005300 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331678005301 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 331678005302 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331678005303 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331678005304 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331678005305 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 331678005306 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 331678005307 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331678005308 Uncharacterized conserved protein [Function unknown]; Region: COG1912 331678005309 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 331678005310 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 331678005311 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331678005312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678005313 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331678005314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678005315 DNA binding residues [nucleotide binding] 331678005316 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 331678005317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678005318 active site 331678005319 HIGH motif; other site 331678005320 nucleotide binding site [chemical binding]; other site 331678005321 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331678005322 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 331678005323 active site 331678005324 KMSKS motif; other site 331678005325 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 331678005326 tRNA binding surface [nucleotide binding]; other site 331678005327 anticodon binding site; other site 331678005328 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 331678005329 Clp protease; Region: CLP_protease; pfam00574 331678005330 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 331678005331 oligomer interface [polypeptide binding]; other site 331678005332 active site residues [active] 331678005333 Thymidylate synthase complementing protein; Region: Thy1; cl03630 331678005334 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 331678005335 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 331678005336 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 331678005337 nucleophile elbow; other site 331678005338 Surface antigen; Region: Bac_surface_Ag; cl03097 331678005339 Survival protein SurE; Region: SurE; cl00448 331678005340 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 331678005341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 331678005342 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 331678005343 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 331678005344 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 331678005345 DsbD alpha interface [polypeptide binding]; other site 331678005346 catalytic residues [active] 331678005347 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331678005348 ResB-like family; Region: ResB; pfam05140 331678005349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678005350 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331678005351 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 331678005352 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 331678005353 glutamine binding [chemical binding]; other site 331678005354 catalytic triad [active] 331678005355 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 331678005356 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 331678005357 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 331678005358 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 331678005359 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 331678005360 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331678005361 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 331678005362 active site 331678005363 Helix-turn-helix domains; Region: HTH; cl00088 331678005364 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 331678005365 Helix-turn-helix domains; Region: HTH; cl00088 331678005366 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331678005367 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 331678005368 NAD(P) binding site [chemical binding]; other site 331678005369 catalytic residues [active] 331678005370 GTPase RsgA; Reviewed; Region: PRK00098 331678005371 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678005372 RNA binding site [nucleotide binding]; other site 331678005373 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 331678005374 GTPase/Zn-binding domain interface [polypeptide binding]; other site 331678005375 GTP/Mg2+ binding site [chemical binding]; other site 331678005376 G4 box; other site 331678005377 G5 box; other site 331678005378 G1 box; other site 331678005379 Switch I region; other site 331678005380 G2 box; other site 331678005381 G3 box; other site 331678005382 Switch II region; other site 331678005383 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 331678005384 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 331678005385 generic binding surface II; other site 331678005386 ssDNA binding site; other site 331678005387 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678005388 ATP binding site [chemical binding]; other site 331678005389 putative Mg++ binding site [ion binding]; other site 331678005390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678005391 nucleotide binding region [chemical binding]; other site 331678005392 ATP-binding site [chemical binding]; other site 331678005393 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 331678005394 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 331678005395 hinge region; other site 331678005396 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 331678005397 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 331678005398 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 331678005399 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 331678005400 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 331678005401 generic binding surface II; other site 331678005402 generic binding surface I; other site 331678005403 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 331678005404 Ligand binding site; other site 331678005405 oligomer interface; other site 331678005406 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 331678005407 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 331678005408 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 331678005409 Citrate synthase; Region: Citrate_synt; pfam00285 331678005410 oxalacetate binding site [chemical binding]; other site 331678005411 citrylCoA binding site [chemical binding]; other site 331678005412 coenzyme A binding site [chemical binding]; other site 331678005413 catalytic triad [active] 331678005414 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 331678005415 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 331678005416 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331678005417 ligand binding site [chemical binding]; other site 331678005418 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 331678005419 putative metal binding site [ion binding]; other site 331678005420 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 331678005421 TPR repeat; Region: TPR_11; pfam13414 331678005422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678005423 binding surface 331678005424 TPR motif; other site 331678005425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 331678005426 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 331678005427 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331678005428 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 331678005429 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 331678005430 dimer interface [polypeptide binding]; other site 331678005431 tetramer interface [polypeptide binding]; other site 331678005432 PYR/PP interface [polypeptide binding]; other site 331678005433 TPP binding site [chemical binding]; other site 331678005434 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 331678005435 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 331678005436 TPP-binding site; other site 331678005437 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 331678005438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678005439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331678005440 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 331678005441 substrate binding site [chemical binding]; other site 331678005442 oxyanion hole (OAH) forming residues; other site 331678005443 trimer interface [polypeptide binding]; other site 331678005444 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 331678005445 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 331678005446 active site 331678005447 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 331678005448 AMP-binding enzyme; Region: AMP-binding; cl15778 331678005449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331678005450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678005451 Coenzyme A binding pocket [chemical binding]; other site 331678005452 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 331678005453 cyanophycin synthetase; Provisional; Region: PRK14016 331678005454 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678005455 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331678005456 FMN binding site [chemical binding]; other site 331678005457 active site 331678005458 substrate binding site [chemical binding]; other site 331678005459 catalytic residue [active] 331678005460 dihydrodipicolinate reductase; Provisional; Region: PRK00048 331678005461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005462 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 331678005463 ParB-like nuclease domain; Region: ParBc; cl02129 331678005464 ParB-like partition proteins; Region: parB_part; TIGR00180 331678005465 KorB domain; Region: KorB; pfam08535 331678005466 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331678005467 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678005468 P-loop; other site 331678005469 Magnesium ion binding site [ion binding]; other site 331678005470 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678005471 Magnesium ion binding site [ion binding]; other site 331678005472 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 331678005473 active site 331678005474 DNA binding site [nucleotide binding] 331678005475 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 331678005476 MgtE intracellular N domain; Region: MgtE_N; cl15244 331678005477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 331678005478 Divalent cation transporter; Region: MgtE; cl00786 331678005479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005480 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 331678005481 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 331678005482 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 331678005483 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 331678005484 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 331678005485 Ligand Binding Site [chemical binding]; other site 331678005486 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678005487 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 331678005488 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 331678005489 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 331678005490 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 331678005491 substrate binding pocket [chemical binding]; other site 331678005492 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 331678005493 B12 binding site [chemical binding]; other site 331678005494 cobalt ligand [ion binding]; other site 331678005495 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 331678005496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 331678005497 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 331678005498 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 331678005499 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 331678005500 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 331678005501 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 331678005502 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678005503 active site residue [active] 331678005504 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 331678005505 Uncharacterized conserved protein [Function unknown]; Region: COG5634 331678005506 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678005507 transketolase; Reviewed; Region: PRK05899 331678005508 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331678005509 TPP-binding site [chemical binding]; other site 331678005510 dimer interface [polypeptide binding]; other site 331678005511 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331678005512 PYR/PP interface [polypeptide binding]; other site 331678005513 dimer interface [polypeptide binding]; other site 331678005514 TPP binding site [chemical binding]; other site 331678005515 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331678005516 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 331678005517 putative active site [active] 331678005518 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 331678005519 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 331678005520 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 331678005521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005522 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 331678005523 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 331678005524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678005525 dimer interface [polypeptide binding]; other site 331678005526 phosphorylation site [posttranslational modification] 331678005527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678005529 ATP binding site [chemical binding]; other site 331678005530 Mg2+ binding site [ion binding]; other site 331678005531 G-X-G motif; other site 331678005532 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331678005533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 331678005534 active site 331678005535 intermolecular recognition site; other site 331678005536 dimerization interface [polypeptide binding]; other site 331678005537 Response regulator receiver domain; Region: Response_reg; pfam00072 331678005538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678005539 active site 331678005540 phosphorylation site [posttranslational modification] 331678005541 intermolecular recognition site; other site 331678005542 dimerization interface [polypeptide binding]; other site 331678005543 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 331678005544 FIST N domain; Region: FIST; cl10701 331678005545 FIST C domain; Region: FIST_C; pfam10442 331678005546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331678005547 Ion channel; Region: Ion_trans_2; cl11596 331678005548 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 331678005549 Protein of unknown function (DUF541); Region: SIMPL; cl01077 331678005550 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005551 enoyl-CoA hydratase; Validated; Region: PRK08139 331678005552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331678005553 substrate binding site [chemical binding]; other site 331678005554 oxyanion hole (OAH) forming residues; other site 331678005555 trimer interface [polypeptide binding]; other site 331678005556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 331678005557 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 331678005558 putative active site [active] 331678005559 Zn binding site [ion binding]; other site 331678005560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678005561 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 331678005562 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 331678005563 putative deacylase active site [active] 331678005564 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678005565 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678005566 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 331678005567 nucleophile elbow; other site 331678005568 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 331678005569 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 331678005570 NAD(P) binding site [chemical binding]; other site 331678005571 catalytic residues [active] 331678005572 AAA domain; Region: AAA_32; pfam13654 331678005573 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 331678005574 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678005575 Ligand Binding Site [chemical binding]; other site 331678005576 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 331678005577 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 331678005578 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 331678005579 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 331678005580 Peptidase family U32; Region: Peptidase_U32; cl03113 331678005581 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 331678005582 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 331678005583 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 331678005584 FAD binding pocket [chemical binding]; other site 331678005585 FAD binding motif [chemical binding]; other site 331678005586 phosphate binding motif [ion binding]; other site 331678005587 beta-alpha-beta structure motif; other site 331678005588 NAD binding pocket [chemical binding]; other site 331678005589 Iron coordination center [ion binding]; other site 331678005590 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 331678005591 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 331678005592 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 331678005593 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 331678005594 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 331678005595 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 331678005596 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678005597 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 331678005598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005599 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 331678005600 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 331678005601 trimer interface [polypeptide binding]; other site 331678005602 putative metal binding site [ion binding]; other site 331678005603 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678005604 Putative addiction module component; Region: Unstab_antitox; cl09921 331678005605 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005606 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005607 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678005608 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 331678005609 putative NAD(P) binding site [chemical binding]; other site 331678005610 active site 331678005611 putative substrate binding site [chemical binding]; other site 331678005612 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331678005613 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678005614 active site 331678005615 Helix-turn-helix domains; Region: HTH; cl00088 331678005616 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005617 Predicted transcriptional regulator [Transcription]; Region: COG2378 331678005618 Helix-turn-helix domains; Region: HTH; cl00088 331678005619 WYL domain; Region: WYL; cl14852 331678005620 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678005621 active site 331678005622 substrate binding site [chemical binding]; other site 331678005623 catalytic site [active] 331678005624 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 331678005625 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005626 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 331678005627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678005628 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 331678005629 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 331678005630 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 331678005631 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 331678005632 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 331678005633 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 331678005634 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 331678005635 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 331678005636 HipA-like N-terminal domain; Region: HipA_N; pfam07805 331678005637 HipA-like C-terminal domain; Region: HipA_C; pfam07804 331678005638 HipA N-terminal domain; Region: Couple_hipA; cl11853 331678005639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678005640 non-specific DNA binding site [nucleotide binding]; other site 331678005641 salt bridge; other site 331678005642 sequence-specific DNA binding site [nucleotide binding]; other site 331678005643 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 331678005644 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 331678005645 Walker A/P-loop; other site 331678005646 ATP binding site [chemical binding]; other site 331678005647 Q-loop/lid; other site 331678005648 ABC transporter signature motif; other site 331678005649 Walker B; other site 331678005650 D-loop; other site 331678005651 H-loop/switch region; other site 331678005652 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 331678005653 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678005654 B12 binding site [chemical binding]; other site 331678005655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005656 FeS/SAM binding site; other site 331678005657 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 331678005658 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 331678005659 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331678005660 Zn2+ binding site [ion binding]; other site 331678005661 Mg2+ binding site [ion binding]; other site 331678005662 YtxH-like protein; Region: YtxH; cl02079 331678005663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678005664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 331678005665 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 331678005666 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 331678005667 hinge; other site 331678005668 active site 331678005669 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 331678005670 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 331678005671 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331678005672 dimer interface [polypeptide binding]; other site 331678005673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678005674 catalytic residue [active] 331678005675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 331678005676 alanine racemase; Reviewed; Region: alr; PRK00053 331678005677 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 331678005678 active site 331678005679 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331678005680 dimer interface [polypeptide binding]; other site 331678005681 substrate binding site [chemical binding]; other site 331678005682 catalytic residues [active] 331678005683 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 331678005684 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 331678005685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005686 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 331678005687 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 331678005688 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 331678005689 FMN binding site [chemical binding]; other site 331678005690 active site 331678005691 catalytic residues [active] 331678005692 substrate binding site [chemical binding]; other site 331678005693 recombinase A; Provisional; Region: recA; PRK09354 331678005694 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 331678005695 hexamer interface [polypeptide binding]; other site 331678005696 Walker A motif; other site 331678005697 ATP binding site [chemical binding]; other site 331678005698 Walker B motif; other site 331678005699 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 331678005700 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 331678005701 putative NADP binding site [chemical binding]; other site 331678005702 putative substrate binding site [chemical binding]; other site 331678005703 active site 331678005704 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005705 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 331678005706 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331678005707 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331678005708 trigger factor; Region: tig; TIGR00115 331678005709 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 331678005710 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 331678005711 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 331678005712 dimerization interface [polypeptide binding]; other site 331678005713 active site 331678005714 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 331678005715 homooctamer interface [polypeptide binding]; other site 331678005716 active site 331678005717 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 331678005718 catalytic center binding site [active] 331678005719 ATP binding site [chemical binding]; other site 331678005720 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678005721 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005722 P loop; other site 331678005723 Nucleotide binding site [chemical binding]; other site 331678005724 DTAP/Switch II; other site 331678005725 Switch I; other site 331678005726 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 331678005727 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 331678005728 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678005729 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005730 P loop; other site 331678005731 Nucleotide binding site [chemical binding]; other site 331678005732 DTAP/Switch II; other site 331678005733 Switch I; other site 331678005734 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005735 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 331678005736 FAD binding pocket [chemical binding]; other site 331678005737 FAD binding motif [chemical binding]; other site 331678005738 phosphate binding motif [ion binding]; other site 331678005739 beta-alpha-beta structure motif; other site 331678005740 NAD binding pocket [chemical binding]; other site 331678005741 Iron coordination center [ion binding]; other site 331678005742 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 331678005743 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 331678005744 dimer interface [polypeptide binding]; other site 331678005745 ssDNA binding site [nucleotide binding]; other site 331678005746 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331678005747 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 331678005748 DNA polymerase III, delta subunit; Region: holA; TIGR01128 331678005749 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678005750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005751 NAD(P) binding site [chemical binding]; other site 331678005752 active site 331678005753 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 331678005754 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678005755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678005756 catalytic residue [active] 331678005757 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 331678005758 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 331678005759 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678005760 N-terminal plug; other site 331678005761 ligand-binding site [chemical binding]; other site 331678005762 magnesium chelatase, H subunit; Region: BchH; TIGR02025 331678005763 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678005764 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678005765 magnesium chelatase subunit H; Provisional; Region: PRK12493 331678005766 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678005767 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678005768 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 331678005769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678005770 S-adenosylmethionine binding site [chemical binding]; other site 331678005771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005772 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 331678005773 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678005774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005775 FeS/SAM binding site; other site 331678005776 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331678005777 putative dimer interface [polypeptide binding]; other site 331678005778 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 331678005779 activation loop (A-loop); other site 331678005780 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 331678005781 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678005782 RF-1 domain; Region: RF-1; cl02875 331678005783 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 331678005784 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 331678005785 structural tetrad; other site 331678005786 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678005787 putative active site [active] 331678005788 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 331678005789 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 331678005790 DXD motif; other site 331678005791 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 331678005792 ATP phosphoribosyltransferase; Region: HisG; cl15266 331678005793 HisG, C-terminal domain; Region: HisG_C; cl06867 331678005794 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 331678005795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678005796 putative active site [active] 331678005797 putative metal binding site [ion binding]; other site 331678005798 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 331678005799 UbiA prenyltransferase family; Region: UbiA; cl00337 331678005800 UbiA prenyltransferase family; Region: UbiA; cl00337 331678005801 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340 331678005802 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331678005803 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005804 FeS/SAM binding site; other site 331678005805 TRAM domain; Region: TRAM; cl01282 331678005806 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 331678005807 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 331678005808 trimerization site [polypeptide binding]; other site 331678005809 active site 331678005810 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 331678005811 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678005812 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 331678005813 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678005814 catalytic residue [active] 331678005815 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 331678005816 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331678005817 dimer interface [polypeptide binding]; other site 331678005818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678005819 catalytic residue [active] 331678005820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678005821 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 331678005822 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 331678005823 Domain of unknown function DUF21; Region: DUF21; pfam01595 331678005824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331678005825 Transporter associated domain; Region: CorC_HlyC; cl08393 331678005826 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 331678005827 active site 331678005828 multimer interface [polypeptide binding]; other site 331678005829 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 331678005830 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 331678005831 Domain of unknown function DUF20; Region: UPF0118; pfam01594 331678005832 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 331678005833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 331678005834 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 331678005835 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 331678005836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678005837 active site 331678005838 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 331678005839 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 331678005840 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 331678005841 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 331678005842 active site 331678005843 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 331678005844 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 331678005845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005846 FeS/SAM binding site; other site 331678005847 HemN C-terminal domain; Region: HemN_C; pfam06969 331678005848 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 331678005849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678005850 active site 331678005851 motif I; other site 331678005852 motif II; other site 331678005853 glycogen synthase; Provisional; Region: PRK14098 331678005854 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 331678005855 ADP-binding pocket [chemical binding]; other site 331678005856 homodimer interface [polypeptide binding]; other site 331678005857 Bacterial Ig-like domain; Region: Big_5; cl01012 331678005858 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 331678005859 Heme NO binding; Region: HNOB; cl15268 331678005860 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 331678005861 Fic family protein [Function unknown]; Region: COG3177 331678005862 Fic/DOC family; Region: Fic; cl00960 331678005863 TfoX N-terminal domain; Region: TfoX_N; cl01167 331678005864 TfoX N-terminal domain; Region: TfoX_N; cl01167 331678005865 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 331678005866 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 331678005867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678005868 motif II; other site 331678005869 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 331678005870 Putative addiction module component; Region: Unstab_antitox; cl09921 331678005871 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 331678005872 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 331678005873 P-loop; other site 331678005874 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 331678005875 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 331678005876 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 331678005877 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 331678005878 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 331678005879 Domain of unknown function DUF77; Region: DUF77; cl00307 331678005880 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 331678005881 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 331678005882 GDP-binding site [chemical binding]; other site 331678005883 ACT binding site; other site 331678005884 IMP binding site; other site 331678005885 Predicted GTPase [General function prediction only]; Region: COG0218 331678005886 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 331678005887 G1 box; other site 331678005888 GTP/Mg2+ binding site [chemical binding]; other site 331678005889 Switch I region; other site 331678005890 G2 box; other site 331678005891 G3 box; other site 331678005892 Switch II region; other site 331678005893 G4 box; other site 331678005894 G5 box; other site 331678005895 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 331678005896 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331678005897 active site 331678005898 HIGH motif; other site 331678005899 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331678005900 KMSKS motif; other site 331678005901 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331678005902 tRNA binding surface [nucleotide binding]; other site 331678005903 anticodon binding site; other site 331678005904 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 331678005905 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331678005906 Substrate binding site; other site 331678005907 Cupin domain; Region: Cupin_2; cl09118 331678005908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 331678005909 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 331678005910 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 331678005911 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 331678005912 alphaNTD homodimer interface [polypeptide binding]; other site 331678005913 alphaNTD - beta interaction site [polypeptide binding]; other site 331678005914 alphaNTD - beta' interaction site [polypeptide binding]; other site 331678005915 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 331678005916 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 331678005917 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 331678005918 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678005919 RNA binding surface [nucleotide binding]; other site 331678005920 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 331678005921 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 331678005922 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 331678005923 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 331678005924 rRNA binding site [nucleotide binding]; other site 331678005925 predicted 30S ribosome binding site; other site 331678005926 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 331678005927 active site 331678005928 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 331678005929 SecY translocase; Region: SecY; pfam00344 331678005930 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 331678005931 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 331678005932 23S rRNA binding site [nucleotide binding]; other site 331678005933 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 331678005934 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 331678005935 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 331678005936 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 331678005937 5S rRNA interface [nucleotide binding]; other site 331678005938 L27 interface [polypeptide binding]; other site 331678005939 23S rRNA interface [nucleotide binding]; other site 331678005940 L5 interface [polypeptide binding]; other site 331678005941 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 331678005942 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331678005943 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331678005944 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 331678005945 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 331678005946 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 331678005947 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 331678005948 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 331678005949 KOW motif; Region: KOW; cl00354 331678005950 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 331678005951 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 331678005952 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 331678005953 putative translocon interaction site; other site 331678005954 23S rRNA interface [nucleotide binding]; other site 331678005955 signal recognition particle (SRP54) interaction site; other site 331678005956 L23 interface [polypeptide binding]; other site 331678005957 trigger factor interaction site; other site 331678005958 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 331678005959 23S rRNA interface [nucleotide binding]; other site 331678005960 5S rRNA interface [nucleotide binding]; other site 331678005961 putative antibiotic binding site [chemical binding]; other site 331678005962 L25 interface [polypeptide binding]; other site 331678005963 L27 interface [polypeptide binding]; other site 331678005964 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 331678005965 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 331678005966 G-X-X-G motif; other site 331678005967 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 331678005968 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 331678005969 putative translocon binding site; other site 331678005970 protein-rRNA interface [nucleotide binding]; other site 331678005971 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 331678005972 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 331678005973 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 331678005974 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 331678005975 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 331678005976 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 331678005977 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 331678005978 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 331678005979 elongation factor Tu; Reviewed; Region: PRK00049 331678005980 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 331678005981 G1 box; other site 331678005982 GEF interaction site [polypeptide binding]; other site 331678005983 GTP/Mg2+ binding site [chemical binding]; other site 331678005984 Switch I region; other site 331678005985 G2 box; other site 331678005986 G3 box; other site 331678005987 Switch II region; other site 331678005988 G4 box; other site 331678005989 G5 box; other site 331678005990 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 331678005991 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 331678005992 Antibiotic Binding Site [chemical binding]; other site 331678005993 elongation factor G; Reviewed; Region: PRK00007 331678005994 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 331678005995 G1 box; other site 331678005996 putative GEF interaction site [polypeptide binding]; other site 331678005997 GTP/Mg2+ binding site [chemical binding]; other site 331678005998 Switch I region; other site 331678005999 G2 box; other site 331678006000 G3 box; other site 331678006001 Switch II region; other site 331678006002 G4 box; other site 331678006003 G5 box; other site 331678006004 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331678006005 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331678006006 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331678006007 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 331678006008 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 331678006009 S17 interaction site [polypeptide binding]; other site 331678006010 S8 interaction site; other site 331678006011 16S rRNA interaction site [nucleotide binding]; other site 331678006012 streptomycin interaction site [chemical binding]; other site 331678006013 23S rRNA interaction site [nucleotide binding]; other site 331678006014 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 331678006015 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331678006016 Predicted membrane protein [Function unknown]; Region: COG4485 331678006017 MatE; Region: MatE; cl10513 331678006018 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 331678006019 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331678006020 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331678006021 Probable Catalytic site; other site 331678006022 metal-binding site 331678006023 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 331678006024 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678006025 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 331678006026 dimerization domain swap beta strand [polypeptide binding]; other site 331678006027 regulatory protein interface [polypeptide binding]; other site 331678006028 active site 331678006029 regulatory phosphorylation site [posttranslational modification]; other site 331678006030 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 331678006031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678006032 Coenzyme A binding pocket [chemical binding]; other site 331678006033 GTPase CgtA; Reviewed; Region: obgE; PRK12299 331678006034 GTP1/OBG; Region: GTP1_OBG; pfam01018 331678006035 Obg GTPase; Region: Obg; cd01898 331678006036 G1 box; other site 331678006037 GTP/Mg2+ binding site [chemical binding]; other site 331678006038 Switch I region; other site 331678006039 G2 box; other site 331678006040 G3 box; other site 331678006041 Switch II region; other site 331678006042 G4 box; other site 331678006043 G5 box; other site 331678006044 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 331678006045 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 331678006046 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 331678006047 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 331678006048 GatB domain; Region: GatB_Yqey; cl11497 331678006049 Family of unknown function (DUF500); Region: DUF500; cl01109 331678006050 Clp amino terminal domain; Region: Clp_N; pfam02861 331678006051 Clp amino terminal domain; Region: Clp_N; pfam02861 331678006052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678006053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331678006054 Walker A motif; other site 331678006055 ATP binding site [chemical binding]; other site 331678006056 Walker B motif; other site 331678006057 arginine finger; other site 331678006058 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678006059 iron-sulfur cluster [ion binding]; other site 331678006060 [2Fe-2S] cluster binding site [ion binding]; other site 331678006061 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331678006062 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 331678006063 active site 331678006064 FMN binding site [chemical binding]; other site 331678006065 substrate binding site [chemical binding]; other site 331678006066 3Fe-4S cluster binding site [ion binding]; other site 331678006067 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331678006068 metal ion-dependent adhesion site (MIDAS); other site 331678006069 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 331678006070 metal ion-dependent adhesion site (MIDAS); other site 331678006071 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 331678006072 Transposase domain (DUF772); Region: DUF772; cl15789 331678006073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678006074 Transposase domain (DUF772); Region: DUF772; cl15789 331678006075 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 331678006076 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 331678006077 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678006078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006079 Walker A/P-loop; other site 331678006080 ATP binding site [chemical binding]; other site 331678006081 Q-loop/lid; other site 331678006082 ABC transporter signature motif; other site 331678006083 Walker B; other site 331678006084 D-loop; other site 331678006085 H-loop/switch region; other site 331678006086 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 331678006087 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 331678006088 putative active site [active] 331678006089 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 331678006090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006091 Walker A/P-loop; other site 331678006092 ATP binding site [chemical binding]; other site 331678006093 Q-loop/lid; other site 331678006094 ABC transporter signature motif; other site 331678006095 Walker B; other site 331678006096 D-loop; other site 331678006097 H-loop/switch region; other site 331678006098 Outer membrane efflux protein; Region: OEP; pfam02321 331678006099 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678006100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678006101 DNA binding residues [nucleotide binding] 331678006102 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 331678006103 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 331678006104 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678006105 RNA polymerase sigma factor; Provisional; Region: PRK12539 331678006106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 331678006107 DNA binding residues [nucleotide binding] 331678006108 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678006109 oligomeric interface; other site 331678006110 putative active site [active] 331678006111 homodimer interface [polypeptide binding]; other site 331678006112 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 331678006113 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331678006114 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331678006115 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331678006116 MoxR-like ATPases [General function prediction only]; Region: COG0714 331678006117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006118 UGMP family protein; Validated; Region: PRK09604 331678006119 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 331678006120 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 331678006121 active site 331678006122 Preprotein translocase subunit; Region: YajC; cl00806 331678006123 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 331678006124 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 331678006125 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 331678006126 catalytic site [active] 331678006127 subunit interface [polypeptide binding]; other site 331678006128 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 331678006129 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678006130 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678006131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006132 FeS/SAM binding site; other site 331678006133 Cytochrome c; Region: Cytochrom_C; cl11414 331678006134 Cytochrome c; Region: Cytochrom_C; cl11414 331678006135 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 331678006136 Membrane transport protein; Region: Mem_trans; cl09117 331678006137 PQ loop repeat; Region: PQ-loop; cl12056 331678006138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006139 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 331678006140 Oxygen tolerance; Region: BatD; pfam13584 331678006141 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 331678006142 MoaE homodimer interface [polypeptide binding]; other site 331678006143 MoaD interaction [polypeptide binding]; other site 331678006144 active site residues [active] 331678006145 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 331678006146 MoaE interaction surface [polypeptide binding]; other site 331678006147 MoeB interaction surface [polypeptide binding]; other site 331678006148 thiocarboxylated glycine; other site 331678006149 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 331678006150 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 331678006151 dimer interface [polypeptide binding]; other site 331678006152 putative functional site; other site 331678006153 putative MPT binding site; other site 331678006154 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 331678006155 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 331678006156 trimer interface [polypeptide binding]; other site 331678006157 dimer interface [polypeptide binding]; other site 331678006158 putative active site [active] 331678006159 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 331678006160 MPT binding site; other site 331678006161 trimer interface [polypeptide binding]; other site 331678006162 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 331678006163 Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476 331678006164 [2Fe-2S] cluster binding site [ion binding]; other site 331678006165 subunit interaction site [polypeptide binding]; other site 331678006166 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678006167 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 331678006168 molybdopterin cofactor binding site; other site 331678006169 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 331678006170 molybdopterin cofactor binding site; other site 331678006171 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 331678006172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006173 FeS/SAM binding site; other site 331678006174 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 331678006175 MOSC domain; Region: MOSC; pfam03473 331678006176 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 331678006177 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678006178 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 331678006179 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678006180 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 331678006181 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 331678006182 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 331678006183 active site 331678006184 catalytic site [active] 331678006185 Histidine kinase N terminal; Region: HisK_N; pfam09385 331678006186 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 331678006187 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490 331678006188 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 331678006189 Walker A motif; other site 331678006190 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 331678006191 GTP binding site; other site 331678006192 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678006193 Ligand Binding Site [chemical binding]; other site 331678006194 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 331678006195 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678006196 catalytic loop [active] 331678006197 iron binding site [ion binding]; other site 331678006198 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 331678006199 FAD binding pocket [chemical binding]; other site 331678006200 FAD binding motif [chemical binding]; other site 331678006201 phosphate binding motif [ion binding]; other site 331678006202 beta-alpha-beta structure motif; other site 331678006203 NAD binding pocket [chemical binding]; other site 331678006204 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 331678006205 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 331678006206 FMN-binding domain; Region: FMN_bind; cl01081 331678006207 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 331678006208 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 331678006209 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 331678006210 thiosulfate reductase PhsA; Provisional; Region: PRK15488 331678006211 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 331678006212 putative [Fe4-S4] binding site [ion binding]; other site 331678006213 putative molybdopterin cofactor binding site [chemical binding]; other site 331678006214 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 331678006215 molybdopterin cofactor binding site; other site 331678006216 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 331678006217 4Fe-4S binding domain; Region: Fer4; cl02805 331678006218 Polysulphide reductase, NrfD; Region: NrfD; cl01295 331678006219 SOUL heme-binding protein; Region: SOUL; pfam04832 331678006220 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 331678006221 Domain of unknown function (DUF202); Region: DUF202; cl09954 331678006222 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 331678006223 hypothetical protein; Provisional; Region: PRK14851 331678006224 dimer interface [polypeptide binding]; other site 331678006225 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 331678006226 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 331678006227 active site 331678006228 Na/Ca binding site [ion binding]; other site 331678006229 catalytic site [active] 331678006230 Peptidase family M48; Region: Peptidase_M48; cl12018 331678006231 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 331678006232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678006233 Coenzyme A binding pocket [chemical binding]; other site 331678006234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006235 Cupin domain; Region: Cupin_2; cl09118 331678006236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 331678006237 SEC-C motif; Region: SEC-C; pfam02810 331678006238 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678006239 TIR domain; Region: TIR_2; cl15770 331678006240 putative transposase OrfB; Reviewed; Region: PHA02517 331678006241 HTH-like domain; Region: HTH_21; pfam13276 331678006242 Integrase core domain; Region: rve; cl01316 331678006243 Integrase core domain; Region: rve_3; cl15866 331678006244 Helix-turn-helix domains; Region: HTH; cl00088 331678006245 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678006246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678006247 non-specific DNA binding site [nucleotide binding]; other site 331678006248 salt bridge; other site 331678006249 sequence-specific DNA binding site [nucleotide binding]; other site 331678006250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006251 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 331678006252 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331678006253 FAD binding domain; Region: FAD_binding_4; pfam01565 331678006254 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 331678006255 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 331678006256 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 331678006257 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 331678006258 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 331678006259 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 331678006260 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331678006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006262 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 331678006263 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 331678006264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678006265 active site 331678006266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006267 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 331678006268 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 331678006269 Transposase domain (DUF772); Region: DUF772; cl15789 331678006270 Transposase domain (DUF772); Region: DUF772; cl15789 331678006271 TPR repeat; Region: TPR_11; pfam13414 331678006272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678006273 binding surface 331678006274 TPR motif; other site 331678006275 TPR repeat; Region: TPR_11; pfam13414 331678006276 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 331678006277 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678006278 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678006279 NeuB family; Region: NeuB; cl00496 331678006280 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331678006281 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 331678006282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678006283 Walker A motif; other site 331678006284 ATP binding site [chemical binding]; other site 331678006285 Walker B motif; other site 331678006286 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 331678006287 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 331678006288 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331678006289 catalytic core [active] 331678006290 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 331678006291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006292 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 331678006293 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 331678006294 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 331678006295 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 331678006296 dimerization interface [polypeptide binding]; other site 331678006297 putative ATP binding site [chemical binding]; other site 331678006298 aspartate kinase III; Validated; Region: PRK09084 331678006299 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 331678006300 nucleotide binding site [chemical binding]; other site 331678006301 substrate binding site [chemical binding]; other site 331678006302 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 331678006303 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 331678006304 NlpC/P60 family; Region: NLPC_P60; cl11438 331678006305 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 331678006306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006307 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 331678006308 Transposase domain (DUF772); Region: DUF772; cl15789 331678006309 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678006310 Transposase domain (DUF772); Region: DUF772; cl15789 331678006311 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 331678006312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006313 S-adenosylmethionine binding site [chemical binding]; other site 331678006314 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 331678006315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331678006316 inhibitor-cofactor binding pocket; inhibition site 331678006317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678006318 catalytic residue [active] 331678006319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006320 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 331678006321 ADP binding site [chemical binding]; other site 331678006322 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 331678006323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006324 S-adenosylmethionine binding site [chemical binding]; other site 331678006325 Protein of unknown function (DUF452); Region: DUF452; cl01062 331678006326 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678006327 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 331678006328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678006329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678006330 catalytic residue [active] 331678006331 biotin synthase; Validated; Region: PRK06256 331678006332 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006333 FeS/SAM binding site; other site 331678006334 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 331678006335 Helix-turn-helix domains; Region: HTH; cl00088 331678006336 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 331678006337 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 331678006338 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 331678006339 Rubrerythrin [Energy production and conversion]; Region: COG1592 331678006340 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 331678006341 binuclear metal center [ion binding]; other site 331678006342 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 331678006343 iron binding site [ion binding]; other site 331678006344 Rubredoxin [Energy production and conversion]; Region: COG1773 331678006345 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331678006346 iron binding site [ion binding]; other site 331678006347 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331678006348 Rubredoxin; Region: Rubredoxin; pfam00301 331678006349 iron binding site [ion binding]; other site 331678006350 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331678006351 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 331678006352 active site 331678006353 FMN binding site [chemical binding]; other site 331678006354 substrate binding site [chemical binding]; other site 331678006355 3Fe-4S cluster binding site [ion binding]; other site 331678006356 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 331678006357 active site 331678006358 metal binding site [ion binding]; metal-binding site 331678006359 DNA topoisomerase I; Validated; Region: PRK06599 331678006360 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 331678006361 active site 331678006362 interdomain interaction site; other site 331678006363 putative metal-binding site [ion binding]; other site 331678006364 nucleotide binding site [chemical binding]; other site 331678006365 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 331678006366 domain I; other site 331678006367 DNA binding groove [nucleotide binding] 331678006368 phosphate binding site [ion binding]; other site 331678006369 domain II; other site 331678006370 domain III; other site 331678006371 nucleotide binding site [chemical binding]; other site 331678006372 catalytic site [active] 331678006373 domain IV; other site 331678006374 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678006375 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678006376 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678006377 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 331678006378 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 331678006379 G1 box; other site 331678006380 GTP/Mg2+ binding site [chemical binding]; other site 331678006381 Switch I region; other site 331678006382 G2 box; other site 331678006383 G3 box; other site 331678006384 Switch II region; other site 331678006385 G4 box; other site 331678006386 G5 box; other site 331678006387 Nucleoside recognition; Region: Gate; cl00486 331678006388 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 331678006389 Nucleoside recognition; Region: Gate; cl00486 331678006390 FeoA domain; Region: FeoA; cl00838 331678006391 aconitate hydratase; Validated; Region: PRK09277 331678006392 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 331678006393 substrate binding site [chemical binding]; other site 331678006394 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 331678006395 ligand binding site [chemical binding]; other site 331678006396 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 331678006397 substrate binding site [chemical binding]; other site 331678006398 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 331678006399 nucleotide binding site/active site [active] 331678006400 HIT family signature motif; other site 331678006401 catalytic residue [active] 331678006402 SprT homologues; Region: SprT; cl01182 331678006403 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 331678006404 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 331678006405 phosphate binding site [ion binding]; other site 331678006406 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 331678006407 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678006408 dimer interface [polypeptide binding]; other site 331678006409 active site 331678006410 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678006411 Esterase/lipase [General function prediction only]; Region: COG1647 331678006412 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 331678006413 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 331678006414 DNA binding site [nucleotide binding] 331678006415 active site 331678006416 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 331678006417 active site 331678006418 intersubunit interactions; other site 331678006419 catalytic residue [active] 331678006420 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 331678006421 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 331678006422 TIR domain; Region: TIR_2; cl15770 331678006423 Uncharacterized conserved protein [Function unknown]; Region: COG1262 331678006424 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 331678006425 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678006426 Domain of unknown function (DUF955); Region: DUF955; cl01076 331678006427 Deoxyhypusine synthase; Region: DS; cl00826 331678006428 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 331678006429 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 331678006430 active site 331678006431 HIGH motif; other site 331678006432 dimer interface [polypeptide binding]; other site 331678006433 KMSKS motif; other site 331678006434 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 331678006435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678006436 motif II; other site 331678006437 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 331678006438 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 331678006439 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 331678006440 active site 331678006441 HIGH motif; other site 331678006442 KMSK motif region; other site 331678006443 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331678006444 tRNA binding surface [nucleotide binding]; other site 331678006445 anticodon binding site; other site 331678006446 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 331678006447 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 331678006448 active site 331678006449 (T/H)XGH motif; other site 331678006450 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 331678006451 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 331678006452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678006453 non-specific DNA binding site [nucleotide binding]; other site 331678006454 salt bridge; other site 331678006455 sequence-specific DNA binding site [nucleotide binding]; other site 331678006456 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 331678006457 Domain of unknown function (DUF955); Region: DUF955; cl01076 331678006458 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 331678006459 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 331678006460 Protein of unknown function (DUF499); Region: DUF499; pfam04465 331678006461 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 331678006462 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 331678006463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006464 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 331678006465 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 331678006466 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 331678006467 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678006468 nucleotide binding region [chemical binding]; other site 331678006469 ATP-binding site [chemical binding]; other site 331678006470 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 331678006471 Plant ATP synthase F0; Region: YMF19; cl07975 331678006472 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 331678006473 Plant ATP synthase F0; Region: YMF19; cl07975 331678006474 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 331678006475 ATP synthase subunit C; Region: ATP-synt_C; cl00466 331678006476 ATP synthase A chain; Region: ATP-synt_A; cl00413 331678006477 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 331678006478 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678006479 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 331678006480 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678006481 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 331678006482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006483 NAD(P) binding site [chemical binding]; other site 331678006484 active site 331678006485 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 331678006486 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 331678006487 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 331678006488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 331678006489 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 331678006490 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 331678006491 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 331678006492 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 331678006493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006494 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678006495 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 331678006496 putative Iron-sulfur protein interface [polypeptide binding]; other site 331678006497 putative proximal heme binding site [chemical binding]; other site 331678006498 putative SdhC-like subunit interface [polypeptide binding]; other site 331678006499 putative distal heme binding site [chemical binding]; other site 331678006500 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 331678006501 putative Iron-sulfur protein interface [polypeptide binding]; other site 331678006502 putative proximal heme binding site [chemical binding]; other site 331678006503 putative SdhD-like interface [polypeptide binding]; other site 331678006504 putative distal heme binding site [chemical binding]; other site 331678006505 cell division protein FtsZ; Validated; Region: PRK09330 331678006506 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 331678006507 nucleotide binding site [chemical binding]; other site 331678006508 SulA interaction site; other site 331678006509 cell division protein FtsA; Region: ftsA; TIGR01174 331678006510 Cell division protein FtsA; Region: FtsA; cl11496 331678006511 Cell division protein FtsA; Region: FtsA; cl11496 331678006512 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 331678006513 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 331678006514 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331678006515 FAD binding domain; Region: FAD_binding_4; pfam01565 331678006516 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 331678006517 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 331678006518 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331678006519 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006520 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006521 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 331678006522 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 331678006523 active site 331678006524 homodimer interface [polypeptide binding]; other site 331678006525 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 331678006526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006527 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 331678006528 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006529 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006530 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 331678006531 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 331678006532 Mg++ binding site [ion binding]; other site 331678006533 putative catalytic motif [active] 331678006534 putative substrate binding site [chemical binding]; other site 331678006535 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331678006536 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 331678006537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006539 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331678006540 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 331678006541 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006542 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006543 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 331678006544 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331678006545 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 331678006546 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 331678006547 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 331678006548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006549 cell division protein MraZ; Reviewed; Region: PRK00326 331678006550 MraZ protein; Region: MraZ; pfam02381 331678006551 MraZ protein; Region: MraZ; pfam02381 331678006552 YacP-like NYN domain; Region: NYN_YacP; cl01491 331678006553 Chorismate mutase type II; Region: CM_2; cl00693 331678006554 YceG-like family; Region: YceG; pfam02618 331678006555 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 331678006556 dimerization interface [polypeptide binding]; other site 331678006557 Phosphoglycerate kinase; Region: PGK; pfam00162 331678006558 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 331678006559 substrate binding site [chemical binding]; other site 331678006560 hinge regions; other site 331678006561 ADP binding site [chemical binding]; other site 331678006562 catalytic site [active] 331678006563 Rhomboid family; Region: Rhomboid; cl11446 331678006564 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 331678006565 exonuclease subunit SbcC; Provisional; Region: PRK10246 331678006566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006567 Walker A/P-loop; other site 331678006568 ATP binding site [chemical binding]; other site 331678006569 Q-loop/lid; other site 331678006570 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 331678006571 ABC transporter signature motif; other site 331678006572 Walker B; other site 331678006573 D-loop; other site 331678006574 H-loop/switch region; other site 331678006575 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 331678006576 exonuclease subunit SbcD; Provisional; Region: PRK10966 331678006577 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 331678006578 active site 331678006579 metal binding site [ion binding]; metal-binding site 331678006580 DNA binding site [nucleotide binding] 331678006581 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 331678006582 Protein of unknown function DUF45; Region: DUF45; cl00636 331678006583 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 331678006584 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 331678006585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678006586 ATP binding site [chemical binding]; other site 331678006587 putative Mg++ binding site [ion binding]; other site 331678006588 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 331678006589 Fic family protein [Function unknown]; Region: COG3177 331678006590 Fic/DOC family; Region: Fic; cl00960 331678006591 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 331678006592 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 331678006593 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 331678006594 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678006595 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678006596 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678006597 KilA-N domain; Region: KilA-N; pfam04383 331678006598 HsdM N-terminal domain; Region: HsdM_N; pfam12161 331678006599 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 331678006600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006601 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 331678006602 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678006603 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 331678006604 putative FMN binding site [chemical binding]; other site 331678006605 NADPH bind site [chemical binding]; other site 331678006606 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 331678006607 putative hydrophobic ligand binding site [chemical binding]; other site 331678006608 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 331678006609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006610 ATP-grasp domain; Region: ATP-grasp_4; cl03087 331678006611 TRAM domain; Region: TRAM; cl01282 331678006612 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 331678006613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006615 S-adenosylmethionine binding site [chemical binding]; other site 331678006616 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 331678006617 fructokinase; Reviewed; Region: PRK09557 331678006618 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 331678006619 active site 331678006620 membrane protein insertase; Provisional; Region: PRK01318 331678006621 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 331678006622 Haemolytic domain; Region: Haemolytic; cl00506 331678006623 Ribonuclease P; Region: Ribonuclease_P; cl00457 331678006624 Ribosomal protein L34; Region: Ribosomal_L34; cl00370