-- dump date 20120504_141734 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290317000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 290317000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 290317000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000004 Walker A motif; other site 290317000005 ATP binding site [chemical binding]; other site 290317000006 Walker B motif; other site 290317000007 arginine finger; other site 290317000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290317000009 DnaA box-binding interface [nucleotide binding]; other site 290317000010 DNA polymerase III subunit beta; Provisional; Region: PRK14941 290317000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290317000012 putative DNA binding surface [nucleotide binding]; other site 290317000013 dimer interface [polypeptide binding]; other site 290317000014 beta-clamp/clamp loader binding surface; other site 290317000015 beta-clamp/translesion DNA polymerase binding surface; other site 290317000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 290317000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000018 Walker A/P-loop; other site 290317000019 ATP binding site [chemical binding]; other site 290317000020 Q-loop/lid; other site 290317000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000022 ABC transporter signature motif; other site 290317000023 Walker B; other site 290317000024 D-loop; other site 290317000025 H-loop/switch region; other site 290317000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 290317000027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317000028 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317000029 Integrase core domain; Region: rve; cl01316 290317000030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317000031 Integrase core domain; Region: rve; cl01316 290317000032 transposase; Provisional; Region: PRK06526 290317000033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000034 Walker A motif; other site 290317000035 ATP binding site [chemical binding]; other site 290317000036 Walker B motif; other site 290317000037 Winged helix-turn helix; Region: HTH_29; pfam13551 290317000038 Winged helix-turn helix; Region: HTH_33; pfam13592 290317000039 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 290317000040 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 290317000041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290317000042 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 290317000043 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317000044 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317000045 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317000046 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290317000047 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290317000048 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 290317000049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290317000050 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317000051 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 290317000052 DNA polymerase type-B family; Region: POLBc; smart00486 290317000053 active site 290317000054 catalytic site [active] 290317000055 substrate binding site [chemical binding]; other site 290317000056 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 290317000057 active site 290317000058 metal-binding site 290317000059 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 290317000060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000061 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 290317000062 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 290317000063 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 290317000064 Cytochrome c; Region: Cytochrom_C; cl11414 290317000065 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290317000066 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 290317000067 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 290317000068 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 290317000069 Protein export membrane protein; Region: SecD_SecF; cl14618 290317000070 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 290317000071 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290317000072 Protein export membrane protein; Region: SecD_SecF; cl14618 290317000073 SurA N-terminal domain; Region: SurA_N_3; cl07813 290317000074 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317000075 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 290317000076 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317000077 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 290317000078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317000079 ATP binding site [chemical binding]; other site 290317000080 Mg2+ binding site [ion binding]; other site 290317000081 G-X-G motif; other site 290317000082 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290317000083 anchoring element; other site 290317000084 dimer interface [polypeptide binding]; other site 290317000085 ATP binding site [chemical binding]; other site 290317000086 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290317000087 active site 290317000088 putative metal-binding site [ion binding]; other site 290317000089 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290317000090 Restriction endonuclease; Region: Mrr_cat; cl00516 290317000091 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290317000092 RNA/DNA hybrid binding site [nucleotide binding]; other site 290317000093 active site 290317000094 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 290317000095 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290317000096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290317000097 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 290317000098 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 290317000099 trimer interface [polypeptide binding]; other site 290317000100 active site 290317000101 substrate binding site [chemical binding]; other site 290317000102 CoA binding site [chemical binding]; other site 290317000103 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290317000104 C-terminal peptidase (prc); Region: prc; TIGR00225 290317000105 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290317000106 protein binding site [polypeptide binding]; other site 290317000107 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290317000108 Catalytic dyad [active] 290317000109 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 290317000110 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 290317000111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000112 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 290317000113 glycyl-tRNA synthetase; Provisional; Region: PRK04173 290317000114 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290317000115 motif 1; other site 290317000116 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 290317000117 active site 290317000118 motif 2; other site 290317000119 motif 3; other site 290317000120 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 290317000121 anticodon binding site; other site 290317000122 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 290317000123 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 290317000124 dimer interface [polypeptide binding]; other site 290317000125 catalytic triad [active] 290317000126 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 290317000127 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290317000128 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 290317000129 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290317000130 alpha subunit interaction interface [polypeptide binding]; other site 290317000131 Walker A motif; other site 290317000132 ATP binding site [chemical binding]; other site 290317000133 Walker B motif; other site 290317000134 inhibitor binding site; inhibition site 290317000135 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290317000136 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 290317000137 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290317000138 catalytic residues [active] 290317000139 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 290317000140 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 290317000141 active site 290317000142 substrate-binding site [chemical binding]; other site 290317000143 metal-binding site [ion binding] 290317000144 GTP binding site [chemical binding]; other site 290317000145 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 290317000146 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 290317000147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317000148 ATP binding site [chemical binding]; other site 290317000149 putative Mg++ binding site [ion binding]; other site 290317000150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317000151 nucleotide binding region [chemical binding]; other site 290317000152 ATP-binding site [chemical binding]; other site 290317000153 RQC domain; Region: RQC; cl09632 290317000154 HRDC domain; Region: HRDC; cl02578 290317000155 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 290317000156 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 290317000157 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 290317000158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317000159 FeS/SAM binding site; other site 290317000160 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 290317000161 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 290317000162 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 290317000163 active site 290317000164 ORF080 virion core protein; Provisional; Region: PHA02682 290317000165 CHAT domain; Region: CHAT; cl02083 290317000166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 290317000167 Bacterial SH3 domain; Region: SH3_3; cl02551 290317000168 Helix-turn-helix domains; Region: HTH; cl00088 290317000169 WHG domain; Region: WHG; pfam13305 290317000170 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317000171 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317000172 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 290317000173 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 290317000174 putative active site [active] 290317000175 putative metal binding site [ion binding]; other site 290317000176 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290317000177 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 290317000178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000179 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317000180 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 290317000181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317000182 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 290317000183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317000185 Integrase core domain; Region: rve; cl01316 290317000186 transposase; Provisional; Region: PRK06526 290317000187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000188 Walker A motif; other site 290317000189 ATP binding site [chemical binding]; other site 290317000190 Walker B motif; other site 290317000191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290317000192 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 290317000193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290317000194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317000195 ATP binding site [chemical binding]; other site 290317000196 Mg2+ binding site [ion binding]; other site 290317000197 G-X-G motif; other site 290317000198 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 290317000199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290317000200 cofactor binding site; other site 290317000201 DNA binding site [nucleotide binding] 290317000202 substrate interaction site [chemical binding]; other site 290317000203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290317000204 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 290317000205 additional DNA contacts [nucleotide binding]; other site 290317000206 mismatch recognition site; other site 290317000207 active site 290317000208 zinc binding site [ion binding]; other site 290317000209 DNA intercalation site [nucleotide binding]; other site 290317000210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317000211 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 290317000212 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 290317000213 cofactor binding site; other site 290317000214 DNA binding site [nucleotide binding] 290317000215 substrate interaction site [chemical binding]; other site 290317000216 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 290317000217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000218 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290317000219 putative active site [active] 290317000220 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290317000221 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 290317000222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317000223 H+ Antiporter protein; Region: 2A0121; TIGR00900 290317000224 putative substrate translocation pore; other site 290317000225 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 290317000226 SelR domain; Region: SelR; pfam01641 290317000227 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 290317000228 oligomeric interface; other site 290317000229 putative active site [active] 290317000230 homodimer interface [polypeptide binding]; other site 290317000231 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 290317000232 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290317000233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317000234 putative substrate translocation pore; other site 290317000235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317000236 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 290317000237 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317000238 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317000239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290317000240 Ligand Binding Site [chemical binding]; other site 290317000241 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290317000242 GAF domain; Region: GAF; cl15785 290317000243 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 290317000244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000245 Walker A motif; other site 290317000246 ATP binding site [chemical binding]; other site 290317000247 Walker B motif; other site 290317000248 arginine finger; other site 290317000249 Helix-turn-helix domains; Region: HTH; cl00088 290317000250 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290317000251 Domain of unknown function DUF21; Region: DUF21; pfam01595 290317000252 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290317000253 Transporter associated domain; Region: CorC_HlyC; cl08393 290317000254 Conserved oligomeric complex COG6; Region: COG6; pfam06419 290317000255 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 290317000256 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290317000257 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 290317000258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000259 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290317000260 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 290317000261 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 290317000262 putative Iron-sulfur protein interface [polypeptide binding]; other site 290317000263 proximal heme binding site [chemical binding]; other site 290317000264 distal heme binding site [chemical binding]; other site 290317000265 putative dimer interface [polypeptide binding]; other site 290317000266 Putative cyclase; Region: Cyclase; cl00814 290317000267 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 290317000268 nucleotide binding site/active site [active] 290317000269 HIT family signature motif; other site 290317000270 catalytic residue [active] 290317000271 aconitate hydratase; Validated; Region: PRK09277 290317000272 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290317000273 substrate binding site [chemical binding]; other site 290317000274 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290317000275 ligand binding site [chemical binding]; other site 290317000276 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290317000277 substrate binding site [chemical binding]; other site 290317000278 FeoA domain; Region: FeoA; cl00838 290317000279 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 290317000280 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 290317000281 G1 box; other site 290317000282 GTP/Mg2+ binding site [chemical binding]; other site 290317000283 Switch I region; other site 290317000284 G2 box; other site 290317000285 G3 box; other site 290317000286 Switch II region; other site 290317000287 G4 box; other site 290317000288 G5 box; other site 290317000289 Nucleoside recognition; Region: Gate; cl00486 290317000290 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 290317000291 Nucleoside recognition; Region: Gate; cl00486 290317000292 DNA topoisomerase I; Validated; Region: PRK06599 290317000293 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290317000294 active site 290317000295 interdomain interaction site; other site 290317000296 putative metal-binding site [ion binding]; other site 290317000297 nucleotide binding site [chemical binding]; other site 290317000298 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290317000299 domain I; other site 290317000300 DNA binding groove [nucleotide binding] 290317000301 phosphate binding site [ion binding]; other site 290317000302 domain II; other site 290317000303 domain III; other site 290317000304 nucleotide binding site [chemical binding]; other site 290317000305 catalytic site [active] 290317000306 domain IV; other site 290317000307 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290317000308 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290317000309 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290317000310 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290317000311 active site 290317000312 metal binding site [ion binding]; metal-binding site 290317000313 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 290317000314 Helix-turn-helix domains; Region: HTH; cl00088 290317000315 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 290317000316 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290317000317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317000318 FeS/SAM binding site; other site 290317000319 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 290317000320 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 290317000321 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290317000322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290317000323 catalytic residue [active] 290317000324 Protein of unknown function (DUF452); Region: DUF452; cl01062 290317000325 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 290317000326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317000327 S-adenosylmethionine binding site [chemical binding]; other site 290317000328 AAA domain; Region: AAA_26; pfam13500 290317000329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000330 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 290317000331 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290317000332 inhibitor-cofactor binding pocket; inhibition site 290317000333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317000334 catalytic residue [active] 290317000335 Dodecin; Region: Dodecin; cl01328 290317000336 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 290317000337 4Fe-4S binding domain; Region: Fer4; cl02805 290317000338 4Fe-4S binding domain; Region: Fer4; cl02805 290317000339 Polysulphide reductase, NrfD; Region: NrfD; cl01295 290317000340 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290317000341 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 290317000342 molybdopterin cofactor binding site; other site 290317000343 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 290317000344 putative molybdopterin cofactor binding site; other site 290317000345 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290317000346 DsrE/DsrF-like family; Region: DrsE; cl00672 290317000347 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290317000348 active site residue [active] 290317000349 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 290317000350 CPxP motif; other site 290317000351 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 290317000352 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 290317000353 catalytic triad [active] 290317000354 DsrC like protein; Region: DsrC; cl01101 290317000355 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 290317000356 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290317000357 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 290317000358 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290317000359 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 290317000360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317000362 4Fe-4S binding domain; Region: Fer4; cl02805 290317000363 DsrE/DsrF-like family; Region: DrsE; cl00672 290317000364 DsrE/DsrF-like family; Region: DrsE; cl00672 290317000365 DsrE/DsrF-like family; Region: DrsE; cl00672 290317000366 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 290317000367 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 290317000368 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290317000369 Cysteine-rich domain; Region: CCG; pfam02754 290317000370 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 290317000371 4Fe-4S binding domain; Region: Fer4; cl02805 290317000372 Polysulphide reductase, NrfD; Region: NrfD; cl01295 290317000373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000374 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 290317000375 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 290317000376 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290317000377 active site 290317000378 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 290317000379 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 290317000380 P-loop; other site 290317000381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000382 NMT1-like family; Region: NMT1_2; cl15260 290317000383 NMT1/THI5 like; Region: NMT1; pfam09084 290317000384 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290317000385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290317000386 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290317000387 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290317000388 Walker A/P-loop; other site 290317000389 ATP binding site [chemical binding]; other site 290317000390 Q-loop/lid; other site 290317000391 ABC transporter signature motif; other site 290317000392 Walker B; other site 290317000393 D-loop; other site 290317000394 H-loop/switch region; other site 290317000395 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290317000396 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 290317000397 Walker A/P-loop; other site 290317000398 ATP binding site [chemical binding]; other site 290317000399 Q-loop/lid; other site 290317000400 ABC transporter signature motif; other site 290317000401 Walker B; other site 290317000402 D-loop; other site 290317000403 H-loop/switch region; other site 290317000404 Cytochrome c; Region: Cytochrom_C; cl11414 290317000405 Cytochrome c; Region: Cytochrom_C; cl11414 290317000406 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 290317000407 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290317000408 ACS interaction site; other site 290317000409 CODH interaction site; other site 290317000410 metal cluster binding site [ion binding]; other site 290317000411 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 290317000412 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 290317000413 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 290317000414 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290317000415 classical (c) SDRs; Region: SDR_c; cd05233 290317000416 NAD(P) binding site [chemical binding]; other site 290317000417 active site 290317000418 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 290317000419 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 290317000420 trmE is a tRNA modification GTPase; Region: trmE; cd04164 290317000421 G1 box; other site 290317000422 GTP/Mg2+ binding site [chemical binding]; other site 290317000423 Switch I region; other site 290317000424 G2 box; other site 290317000425 Switch II region; other site 290317000426 G3 box; other site 290317000427 G4 box; other site 290317000428 G5 box; other site 290317000429 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 290317000430 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290317000431 active site residue [active] 290317000432 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 290317000433 short chain dehydrogenase; Provisional; Region: PRK08251 290317000434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000435 NAD(P) binding site [chemical binding]; other site 290317000436 active site 290317000437 TIR domain; Region: TIR_2; cl15770 290317000438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290317000439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000440 binding surface 290317000441 TPR motif; other site 290317000442 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 290317000443 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 290317000444 transmembrane helices; other site 290317000445 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290317000446 Leucine carboxyl methyltransferase; Region: LCM; cl01306 290317000447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290317000448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317000449 ATP binding site [chemical binding]; other site 290317000450 G-X-G motif; other site 290317000451 Response regulator receiver domain; Region: Response_reg; pfam00072 290317000452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317000453 active site 290317000454 phosphorylation site [posttranslational modification] 290317000455 intermolecular recognition site; other site 290317000456 dimerization interface [polypeptide binding]; other site 290317000457 Response regulator receiver domain; Region: Response_reg; pfam00072 290317000458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317000459 active site 290317000460 phosphorylation site [posttranslational modification] 290317000461 intermolecular recognition site; other site 290317000462 dimerization interface [polypeptide binding]; other site 290317000463 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290317000464 putative binding surface; other site 290317000465 active site 290317000466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000467 binding surface 290317000468 TPR motif; other site 290317000469 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 290317000470 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 290317000471 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 290317000472 NAD(P) binding site [chemical binding]; other site 290317000473 Transglycosylase; Region: Transgly; cl07896 290317000474 Cytochrome c; Region: Cytochrom_C; cl11414 290317000475 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 290317000476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317000477 ATP binding site [chemical binding]; other site 290317000478 Mg2+ binding site [ion binding]; other site 290317000479 G-X-G motif; other site 290317000480 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 290317000481 ATP binding site [chemical binding]; other site 290317000482 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 290317000483 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 290317000484 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290317000485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290317000486 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290317000487 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317000488 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290317000489 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 290317000490 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290317000491 substrate binding site [chemical binding]; other site 290317000492 active site 290317000493 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 290317000494 Cysteine-rich domain; Region: CCG; pfam02754 290317000495 Cysteine-rich domain; Region: CCG; pfam02754 290317000496 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290317000497 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 290317000498 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290317000499 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 290317000500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000501 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290317000502 FOG: CBS domain [General function prediction only]; Region: COG0517 290317000503 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 290317000504 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290317000505 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290317000506 Protein export membrane protein; Region: SecD_SecF; cl14618 290317000507 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317000508 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290317000509 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290317000510 putative homotetramer interface [polypeptide binding]; other site 290317000511 putative homodimer interface [polypeptide binding]; other site 290317000512 putative allosteric switch controlling residues; other site 290317000513 putative metal binding site [ion binding]; other site 290317000514 putative homodimer-homodimer interface [polypeptide binding]; other site 290317000515 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317000516 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317000517 Phospholipid methyltransferase; Region: PEMT; cl00763 290317000518 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 290317000519 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 290317000520 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290317000521 classical (c) SDRs; Region: SDR_c; cd05233 290317000522 NAD(P) binding site [chemical binding]; other site 290317000523 active site 290317000524 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 290317000525 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 290317000526 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 290317000527 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 290317000528 putative active site; other site 290317000529 catalytic residue [active] 290317000530 short chain dehydrogenase; Validated; Region: PRK08324 290317000531 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 290317000532 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 290317000533 putative NAD(P) binding site [chemical binding]; other site 290317000534 active site 290317000535 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 290317000536 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 290317000537 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 290317000538 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 290317000539 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317000540 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290317000541 Phosphotransferase enzyme family; Region: APH; pfam01636 290317000542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290317000543 substrate binding site [chemical binding]; other site 290317000544 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290317000545 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 290317000546 Substrate binding site; other site 290317000547 metal-binding site 290317000548 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290317000549 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 290317000550 Sodium:solute symporter family; Region: SSF; cl00456 290317000551 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 290317000552 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290317000553 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290317000554 NAD(P) binding site [chemical binding]; other site 290317000555 putative active site [active] 290317000556 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317000557 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290317000558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317000559 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317000560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317000561 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290317000562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317000563 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290317000564 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290317000565 P loop; other site 290317000566 Nucleotide binding site [chemical binding]; other site 290317000567 DTAP/Switch II; other site 290317000568 Switch I; other site 290317000569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000570 TPR repeat; Region: TPR_11; pfam13414 290317000571 binding surface 290317000572 TPR motif; other site 290317000573 TPR repeat; Region: TPR_11; pfam13414 290317000574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000575 binding surface 290317000576 TPR motif; other site 290317000577 TPR repeat; Region: TPR_11; pfam13414 290317000578 TPR repeat; Region: TPR_11; pfam13414 290317000579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000580 binding surface 290317000581 TPR motif; other site 290317000582 TPR repeat; Region: TPR_11; pfam13414 290317000583 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 290317000584 Rubredoxin [Energy production and conversion]; Region: COG1773 290317000585 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290317000586 iron binding site [ion binding]; other site 290317000587 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290317000588 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 290317000589 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 290317000590 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 290317000591 4Fe-4S binding domain; Region: Fer4; cl02805 290317000592 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 290317000593 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 290317000594 Ligand binding site; other site 290317000595 Putative Catalytic site; other site 290317000596 DXD motif; other site 290317000597 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 290317000598 elongation factor G; Reviewed; Region: PRK12740 290317000599 G1 box; other site 290317000600 putative GEF interaction site [polypeptide binding]; other site 290317000601 GTP/Mg2+ binding site [chemical binding]; other site 290317000602 Switch I region; other site 290317000603 G2 box; other site 290317000604 G3 box; other site 290317000605 Switch II region; other site 290317000606 G4 box; other site 290317000607 G5 box; other site 290317000608 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290317000609 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290317000610 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290317000611 enolase; Provisional; Region: eno; PRK00077 290317000612 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290317000613 dimer interface [polypeptide binding]; other site 290317000614 metal binding site [ion binding]; metal-binding site 290317000615 substrate binding pocket [chemical binding]; other site 290317000616 Septum formation initiator; Region: DivIC; cl11433 290317000617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 290317000618 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 290317000619 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 290317000620 classical (c) SDRs; Region: SDR_c; cd05233 290317000621 NAD(P) binding site [chemical binding]; other site 290317000622 active site 290317000623 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 290317000624 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290317000625 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290317000626 putative homodimer interface [polypeptide binding]; other site 290317000627 KOW motif; Region: KOW; cl00354 290317000628 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290317000629 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290317000630 23S rRNA interface [nucleotide binding]; other site 290317000631 L7/L12 interface [polypeptide binding]; other site 290317000632 putative thiostrepton binding site; other site 290317000633 L25 interface [polypeptide binding]; other site 290317000634 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290317000635 mRNA/rRNA interface [nucleotide binding]; other site 290317000636 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290317000637 23S rRNA interface [nucleotide binding]; other site 290317000638 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 290317000639 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290317000640 core dimer interface [polypeptide binding]; other site 290317000641 peripheral dimer interface [polypeptide binding]; other site 290317000642 L10 interface [polypeptide binding]; other site 290317000643 L11 interface [polypeptide binding]; other site 290317000644 putative EF-Tu interaction site [polypeptide binding]; other site 290317000645 putative EF-G interaction site [polypeptide binding]; other site 290317000646 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 290317000647 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 290317000648 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290317000649 RPB12 interaction site [polypeptide binding]; other site 290317000650 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 290317000651 RPB11 interaction site [polypeptide binding]; other site 290317000652 RPB12 interaction site [polypeptide binding]; other site 290317000653 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290317000654 RPB3 interaction site [polypeptide binding]; other site 290317000655 RPB1 interaction site [polypeptide binding]; other site 290317000656 RPB11 interaction site [polypeptide binding]; other site 290317000657 RPB10 interaction site [polypeptide binding]; other site 290317000658 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290317000659 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 290317000660 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 290317000661 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290317000662 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 290317000663 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290317000664 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290317000665 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290317000666 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 290317000667 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290317000668 DNA binding site [nucleotide binding] 290317000669 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290317000670 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290317000671 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290317000672 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 290317000673 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290317000674 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 290317000675 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290317000676 carboxyltransferase (CT) interaction site; other site 290317000677 biotinylation site [posttranslational modification]; other site 290317000678 elongation factor P; Validated; Region: PRK00529 290317000679 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290317000680 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290317000681 RNA binding site [nucleotide binding]; other site 290317000682 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290317000683 RNA binding site [nucleotide binding]; other site 290317000684 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290317000685 IHF - DNA interface [nucleotide binding]; other site 290317000686 IHF dimer interface [polypeptide binding]; other site 290317000687 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 290317000688 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290317000689 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 290317000690 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 290317000691 TPP-binding site [chemical binding]; other site 290317000692 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 290317000693 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 290317000694 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290317000695 dimer interface [polypeptide binding]; other site 290317000696 PYR/PP interface [polypeptide binding]; other site 290317000697 TPP binding site [chemical binding]; other site 290317000698 substrate binding site [chemical binding]; other site 290317000699 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290317000700 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 290317000701 motif 1; other site 290317000702 active site 290317000703 motif 2; other site 290317000704 motif 3; other site 290317000705 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 290317000706 DHHA1 domain; Region: DHHA1; pfam02272 290317000707 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 290317000708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317000709 Ferredoxin [Energy production and conversion]; Region: COG1146 290317000710 Ferredoxin [Energy production and conversion]; Region: COG1146 290317000711 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290317000712 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290317000713 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290317000714 HipA N-terminal domain; Region: Couple_hipA; cl11853 290317000715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290317000716 non-specific DNA binding site [nucleotide binding]; other site 290317000717 salt bridge; other site 290317000718 sequence-specific DNA binding site [nucleotide binding]; other site 290317000719 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 290317000720 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 290317000721 phosphoserine phosphatase SerB; Region: serB; TIGR00338 290317000722 viral phosphatase superfamily protein; Provisional; Region: PHA03398 290317000723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317000724 motif II; other site 290317000725 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290317000726 Putative addiction module component; Region: Unstab_antitox; cl09921 290317000727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317000728 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317000729 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317000730 integron integrase; Region: integrase_gron; TIGR02249 290317000731 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 290317000732 Int/Topo IB signature motif; other site 290317000733 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317000734 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290317000735 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317000736 Glucuronate isomerase; Region: UxaC; cl00829 290317000737 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317000738 HNH endonuclease; Region: HNH_5; pfam14279 290317000739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317000740 Integrase core domain; Region: rve; cl01316 290317000741 transposase; Provisional; Region: PRK06526 290317000742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000743 Walker A motif; other site 290317000744 ATP binding site [chemical binding]; other site 290317000745 Walker B motif; other site 290317000746 TIR domain; Region: TIR_2; cl15770 290317000747 CAAX protease self-immunity; Region: Abi; cl00558 290317000748 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 290317000749 dimer interface [polypeptide binding]; other site 290317000750 [2Fe-2S] cluster binding site [ion binding]; other site 290317000751 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 290317000752 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 290317000753 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290317000754 Protein of unknown function (DUF497); Region: DUF497; cl01108 290317000755 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 290317000756 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 290317000757 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 290317000758 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 290317000759 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 290317000760 active site 290317000761 NTP binding site [chemical binding]; other site 290317000762 metal binding triad [ion binding]; metal-binding site 290317000763 antibiotic binding site [chemical binding]; other site 290317000764 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290317000765 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 290317000766 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290317000767 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290317000768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317000769 motif II; other site 290317000770 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290317000771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000772 Helix-turn-helix domains; Region: HTH; cl00088 290317000773 TPR repeat; Region: TPR_11; pfam13414 290317000774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000775 binding surface 290317000776 TPR motif; other site 290317000777 TPR repeat; Region: TPR_11; pfam13414 290317000778 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317000779 binding surface 290317000780 TPR motif; other site 290317000781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000782 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000783 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290317000784 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290317000785 GMP synthase; Reviewed; Region: guaA; PRK00074 290317000786 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290317000787 AMP/PPi binding site [chemical binding]; other site 290317000788 candidate oxyanion hole; other site 290317000789 catalytic triad [active] 290317000790 potential glutamine specificity residues [chemical binding]; other site 290317000791 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290317000792 ATP Binding subdomain [chemical binding]; other site 290317000793 Ligand Binding sites [chemical binding]; other site 290317000794 Dimerization subdomain; other site 290317000795 Transglycosylase; Region: Transgly; cl07896 290317000796 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290317000797 N-terminal Mad Homology 1 (MH1) domain; Region: MH1; cl00055 290317000798 DNA binding site [nucleotide binding] 290317000799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290317000800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317000801 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317000802 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290317000803 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 290317000804 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 290317000805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000806 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 290317000807 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 290317000808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290317000809 Surface antigen; Region: Surface_Ag_2; cl01155 290317000810 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290317000811 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290317000812 putative NAD(P) binding site [chemical binding]; other site 290317000813 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 290317000814 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 290317000815 catalytic triad [active] 290317000816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000817 AAA domain; Region: AAA_28; pfam13521 290317000818 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290317000819 metal binding site 2 [ion binding]; metal-binding site 290317000820 putative DNA binding helix; other site 290317000821 metal binding site 1 [ion binding]; metal-binding site 290317000822 dimer interface [polypeptide binding]; other site 290317000823 structural Zn2+ binding site [ion binding]; other site 290317000824 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 290317000825 FeoA domain; Region: FeoA; cl00838 290317000826 Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341 290317000827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317000828 G1 box; other site 290317000829 GTP/Mg2+ binding site [chemical binding]; other site 290317000830 Helix-turn-helix domains; Region: HTH; cl00088 290317000831 Winged helix-turn helix; Region: HTH_29; pfam13551 290317000832 Winged helix-turn helix; Region: HTH_33; pfam13592 290317000833 Integrase core domain; Region: rve; cl01316 290317000834 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 290317000835 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 290317000836 Switch I region; other site 290317000837 G2 box; other site 290317000838 G3 box; other site 290317000839 Switch II region; other site 290317000840 GTP/Mg2+ binding site [chemical binding]; other site 290317000841 G4 box; other site 290317000842 G5 box; other site 290317000843 Nucleoside recognition; Region: Gate; cl00486 290317000844 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 290317000845 Helix-turn-helix domains; Region: HTH; cl00088 290317000846 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317000847 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290317000848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317000849 Integrase core domain; Region: rve; cl01316 290317000850 transposase; Provisional; Region: PRK06526 290317000851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000852 Walker A motif; other site 290317000853 ATP binding site [chemical binding]; other site 290317000854 Walker B motif; other site 290317000855 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317000856 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317000857 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 290317000858 Clp amino terminal domain; Region: Clp_N; pfam02861 290317000859 Clp amino terminal domain; Region: Clp_N; pfam02861 290317000860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000861 Walker A motif; other site 290317000862 ATP binding site [chemical binding]; other site 290317000863 Walker B motif; other site 290317000864 arginine finger; other site 290317000865 UvrB/uvrC motif; Region: UVR; pfam02151 290317000866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317000867 Walker A motif; other site 290317000868 ATP binding site [chemical binding]; other site 290317000869 Walker B motif; other site 290317000870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290317000871 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290317000872 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290317000873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317000874 catalytic residue [active] 290317000875 thiamine monophosphate kinase; Provisional; Region: PRK05731 290317000876 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290317000877 ATP binding site [chemical binding]; other site 290317000878 dimerization interface [polypeptide binding]; other site 290317000879 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290317000880 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 290317000881 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290317000882 P loop; other site 290317000883 GTP binding site [chemical binding]; other site 290317000884 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 290317000885 GIY-YIG motif/motif A; other site 290317000886 putative active site [active] 290317000887 putative metal binding site [ion binding]; other site 290317000888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000889 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 290317000890 SurA N-terminal domain; Region: SurA_N_3; cl07813 290317000891 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317000892 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317000893 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317000894 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317000895 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290317000896 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 290317000897 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 290317000898 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290317000899 replicative DNA helicase; Region: DnaB; TIGR00665 290317000900 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290317000901 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290317000902 Walker A motif; other site 290317000903 ATP binding site [chemical binding]; other site 290317000904 Walker B motif; other site 290317000905 DNA binding loops [nucleotide binding] 290317000906 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 290317000907 Fe-S cluster binding site [ion binding]; other site 290317000908 active site 290317000909 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290317000910 Flavoprotein; Region: Flavoprotein; cl08021 290317000911 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 290317000912 Family of unknown function (DUF490); Region: DUF490; pfam04357 290317000913 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290317000914 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 290317000915 active site 290317000916 HIGH motif; other site 290317000917 nucleotide binding site [chemical binding]; other site 290317000918 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290317000919 putative acyl-acceptor binding pocket; other site 290317000920 GtrA-like protein; Region: GtrA; cl00971 290317000921 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 290317000922 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290317000923 Ligand binding site; other site 290317000924 Putative Catalytic site; other site 290317000925 DXD motif; other site 290317000926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317000927 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290317000928 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290317000929 Probable Catalytic site; other site 290317000930 metal-binding site 290317000931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317000932 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317000933 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 290317000934 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317000935 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 290317000936 Walker A/P-loop; other site 290317000937 ATP binding site [chemical binding]; other site 290317000938 Q-loop/lid; other site 290317000939 ABC transporter signature motif; other site 290317000940 Walker B; other site 290317000941 D-loop; other site 290317000942 H-loop/switch region; other site 290317000943 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 290317000944 Probable Catalytic site; other site 290317000945 metal-binding site 290317000946 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290317000947 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290317000948 Probable Catalytic site; other site 290317000949 metal-binding site 290317000950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317000951 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290317000952 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290317000953 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 290317000954 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317000955 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290317000956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317000957 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317000958 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290317000959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317000960 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 290317000961 putative ADP-binding pocket [chemical binding]; other site 290317000962 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290317000963 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290317000964 putative active site [active] 290317000965 CAAX protease self-immunity; Region: Abi; cl00558 290317000966 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 290317000967 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290317000968 active site 290317000969 phosphorylation site [posttranslational modification] 290317000970 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 290317000971 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 290317000972 dimer interface [polypeptide binding]; other site 290317000973 motif 1; other site 290317000974 active site 290317000975 motif 2; other site 290317000976 motif 3; other site 290317000977 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290317000978 anticodon binding site; other site 290317000979 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290317000980 ribosome maturation protein RimP; Reviewed; Region: PRK00092 290317000981 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 290317000982 NusA N-terminal domain; Region: NusA_N; pfam08529 290317000983 transcription termination factor NusA; Region: NusA; TIGR01953 290317000984 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290317000985 RNA binding site [nucleotide binding]; other site 290317000986 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290317000987 G-X-X-G motif; other site 290317000988 ribonuclease E; Reviewed; Region: rne; PRK10811 290317000989 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290317000990 translation initiation factor IF-2; Region: IF-2; TIGR00487 290317000991 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 290317000992 G1 box; other site 290317000993 putative GEF interaction site [polypeptide binding]; other site 290317000994 GTP/Mg2+ binding site [chemical binding]; other site 290317000995 Switch I region; other site 290317000996 G2 box; other site 290317000997 G3 box; other site 290317000998 Switch II region; other site 290317000999 G4 box; other site 290317001000 G5 box; other site 290317001001 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290317001002 Translation-initiation factor 2; Region: IF-2; pfam11987 290317001003 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290317001004 Ribosome-binding factor A; Region: RBFA; cl00542 290317001005 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 290317001006 active site 290317001007 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290317001008 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290317001009 active site 290317001010 Riboflavin kinase; Region: Flavokinase; cl03312 290317001011 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290317001012 16S/18S rRNA binding site [nucleotide binding]; other site 290317001013 S13e-L30e interaction site [polypeptide binding]; other site 290317001014 25S rRNA binding site [nucleotide binding]; other site 290317001015 hypothetical protein; Provisional; Region: PRK11820 290317001016 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 290317001017 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 290317001018 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290317001019 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290317001020 catalytic site [active] 290317001021 G-X2-G-X-G-K; other site 290317001022 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290317001023 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290317001024 active site 290317001025 metal binding site [ion binding]; metal-binding site 290317001026 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290317001027 Substrate binding site; other site 290317001028 Mg++ binding site; other site 290317001029 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290317001030 tetramerization interface [polypeptide binding]; other site 290317001031 active site 290317001032 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 290317001033 periplasmic chaperone; Provisional; Region: PRK10780 290317001034 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 290317001035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001036 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 290317001037 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290317001038 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290317001039 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290317001040 substrate binding pocket [chemical binding]; other site 290317001041 chain length determination region; other site 290317001042 substrate-Mg2+ binding site; other site 290317001043 catalytic residues [active] 290317001044 aspartate-rich region 1; other site 290317001045 active site lid residues [active] 290317001046 aspartate-rich region 2; other site 290317001047 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 290317001048 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 290317001049 homotetramer interface [polypeptide binding]; other site 290317001050 FMN binding site [chemical binding]; other site 290317001051 homodimer contacts [polypeptide binding]; other site 290317001052 putative active site [active] 290317001053 putative substrate binding site [chemical binding]; other site 290317001054 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290317001055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317001056 FtsX-like permease family; Region: FtsX; cl15850 290317001057 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290317001058 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317001059 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 290317001060 Walker A/P-loop; other site 290317001061 ATP binding site [chemical binding]; other site 290317001062 Q-loop/lid; other site 290317001063 ABC transporter signature motif; other site 290317001064 Walker B; other site 290317001065 D-loop; other site 290317001066 H-loop/switch region; other site 290317001067 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 290317001068 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 290317001069 active site 290317001070 substrate binding site [chemical binding]; other site 290317001071 metal binding site [ion binding]; metal-binding site 290317001072 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 290317001073 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290317001074 RuvA N terminal domain; Region: RuvA_N; pfam01330 290317001075 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 290317001076 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 290317001077 transcription termination factor Rho; Provisional; Region: rho; PRK09376 290317001078 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 290317001079 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 290317001080 RNA binding site [nucleotide binding]; other site 290317001081 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 290317001082 multimer interface [polypeptide binding]; other site 290317001083 Walker A motif; other site 290317001084 ATP binding site [chemical binding]; other site 290317001085 Walker B motif; other site 290317001086 Surface antigen; Region: Surface_Ag_2; cl01155 290317001087 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 290317001088 UvrB/uvrC motif; Region: UVR; pfam02151 290317001089 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 290317001090 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 290317001091 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 290317001092 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 290317001093 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 290317001094 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 290317001095 Surface antigen; Region: Bac_surface_Ag; cl03097 290317001096 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290317001097 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290317001098 catalytic residue [active] 290317001099 putative FPP diphosphate binding site; other site 290317001100 putative FPP binding hydrophobic cleft; other site 290317001101 dimer interface [polypeptide binding]; other site 290317001102 putative IPP diphosphate binding site; other site 290317001103 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290317001104 Amidase; Region: Amidase; cl11426 290317001105 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290317001106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001107 CoA-ligase; Region: Ligase_CoA; cl02894 290317001108 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 290317001109 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 290317001110 putative active site [active] 290317001111 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 290317001112 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290317001113 MatE; Region: MatE; cl10513 290317001114 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 290317001115 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 290317001116 dimer interface [polypeptide binding]; other site 290317001117 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290317001118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290317001119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290317001120 DNA binding residues [nucleotide binding] 290317001121 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 290317001122 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 290317001123 active site 290317001124 substrate binding site [chemical binding]; other site 290317001125 metal binding site [ion binding]; metal-binding site 290317001126 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 290317001127 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 290317001128 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 290317001129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290317001130 catalytic loop [active] 290317001131 iron binding site [ion binding]; other site 290317001132 LytB protein; Region: LYTB; cl00507 290317001133 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 290317001134 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290317001135 GTP-binding protein YchF; Reviewed; Region: PRK09601 290317001136 YchF GTPase; Region: YchF; cd01900 290317001137 G1 box; other site 290317001138 GTP/Mg2+ binding site [chemical binding]; other site 290317001139 Switch I region; other site 290317001140 G2 box; other site 290317001141 Switch II region; other site 290317001142 G3 box; other site 290317001143 G4 box; other site 290317001144 G5 box; other site 290317001145 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290317001146 cytidylate kinase; Provisional; Region: cmk; PRK00023 290317001147 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290317001148 CMP-binding site; other site 290317001149 The sites determining sugar specificity; other site 290317001150 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 290317001151 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 290317001152 RNA binding site [nucleotide binding]; other site 290317001153 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290317001154 RNA binding site [nucleotide binding]; other site 290317001155 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 290317001156 RNA binding site [nucleotide binding]; other site 290317001157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290317001158 RNA binding site [nucleotide binding]; other site 290317001159 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690 290317001160 RNA binding site [nucleotide binding]; other site 290317001161 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290317001162 RNA binding site [nucleotide binding]; other site 290317001163 GTPase Era; Reviewed; Region: era; PRK00089 290317001164 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 290317001165 G1 box; other site 290317001166 GTP/Mg2+ binding site [chemical binding]; other site 290317001167 Switch I region; other site 290317001168 G2 box; other site 290317001169 Switch II region; other site 290317001170 G3 box; other site 290317001171 G4 box; other site 290317001172 G5 box; other site 290317001173 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 290317001174 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290317001175 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 290317001176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317001177 FeS/SAM binding site; other site 290317001178 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 290317001179 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290317001180 IHF dimer interface [polypeptide binding]; other site 290317001181 IHF - DNA interface [nucleotide binding]; other site 290317001182 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 290317001183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317001184 Walker B motif; other site 290317001185 arginine finger; other site 290317001186 Peptidase family M41; Region: Peptidase_M41; pfam01434 290317001187 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290317001188 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290317001189 HIGH motif; other site 290317001190 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290317001191 active site 290317001192 KMSKS motif; other site 290317001193 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 290317001194 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290317001195 iron-sulfur cluster [ion binding]; other site 290317001196 [2Fe-2S] cluster binding site [ion binding]; other site 290317001197 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290317001198 intrachain domain interface; other site 290317001199 interchain domain interface [polypeptide binding]; other site 290317001200 heme bH binding site [chemical binding]; other site 290317001201 heme bL binding site [chemical binding]; other site 290317001202 Qo binding site; other site 290317001203 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 290317001204 intrachain domain interface; other site 290317001205 Qi binding site; other site 290317001206 interchain domain interface [polypeptide binding]; other site 290317001207 Qo binding site; other site 290317001208 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290317001209 active site 290317001210 catalytic site [active] 290317001211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290317001212 classical (c) SDRs; Region: SDR_c; cd05233 290317001213 NAD(P) binding site [chemical binding]; other site 290317001214 active site 290317001215 TOBE domain; Region: TOBE_2; cl01440 290317001216 TOBE domain; Region: TOBE_2; cl01440 290317001217 Helix-turn-helix domains; Region: HTH; cl00088 290317001218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290317001219 dimerization interface [polypeptide binding]; other site 290317001220 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 290317001221 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 290317001222 Walker A/P-loop; other site 290317001223 ATP binding site [chemical binding]; other site 290317001224 Q-loop/lid; other site 290317001225 ABC transporter signature motif; other site 290317001226 Walker B; other site 290317001227 D-loop; other site 290317001228 H-loop/switch region; other site 290317001229 TOBE domain; Region: TOBE_2; cl01440 290317001230 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290317001231 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 290317001232 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290317001233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290317001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317001235 dimer interface [polypeptide binding]; other site 290317001236 conserved gate region; other site 290317001237 putative PBP binding loops; other site 290317001238 ABC-ATPase subunit interface; other site 290317001239 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 290317001240 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 290317001241 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 290317001242 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290317001243 N-terminal plug; other site 290317001244 ligand-binding site [chemical binding]; other site 290317001245 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290317001246 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290317001247 dimer interface [polypeptide binding]; other site 290317001248 putative PBP binding regions; other site 290317001249 ABC-ATPase subunit interface; other site 290317001250 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290317001251 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290317001252 Walker A/P-loop; other site 290317001253 ATP binding site [chemical binding]; other site 290317001254 Q-loop/lid; other site 290317001255 ABC transporter signature motif; other site 290317001256 Walker B; other site 290317001257 D-loop; other site 290317001258 H-loop/switch region; other site 290317001259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317001260 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 290317001261 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 290317001262 putative ligand binding residues [chemical binding]; other site 290317001263 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284 290317001264 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290317001265 Moco binding site; other site 290317001266 metal coordination site [ion binding]; other site 290317001267 Cytochrome c; Region: Cytochrom_C; cl11414 290317001268 Cytochrome c; Region: Cytochrom_C; cl11414 290317001269 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317001270 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 290317001271 Walker A/P-loop; other site 290317001272 ATP binding site [chemical binding]; other site 290317001273 Q-loop/lid; other site 290317001274 ABC transporter signature motif; other site 290317001275 Walker B; other site 290317001276 D-loop; other site 290317001277 H-loop/switch region; other site 290317001278 TOBE domain; Region: TOBE_2; cl01440 290317001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317001280 putative PBP binding loops; other site 290317001281 ABC-ATPase subunit interface; other site 290317001282 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 290317001283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290317001284 molybdenum transport protein ModD; Provisional; Region: PRK06096 290317001285 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 290317001286 dimerization interface [polypeptide binding]; other site 290317001287 active site 290317001288 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290317001289 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290317001290 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 290317001291 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317001292 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317001293 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 290317001294 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 290317001295 putative active site [active] 290317001296 putative NTP binding site [chemical binding]; other site 290317001297 putative nucleic acid binding site [nucleotide binding]; other site 290317001298 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317001299 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 290317001300 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317001301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290317001302 dimerization interface [polypeptide binding]; other site 290317001303 putative DNA binding site [nucleotide binding]; other site 290317001304 putative Zn2+ binding site [ion binding]; other site 290317001305 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290317001306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290317001307 active site residue [active] 290317001308 Predicted permeases [General function prediction only]; Region: COG0701 290317001309 Predicted permease; Region: DUF318; pfam03773 290317001310 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290317001311 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290317001312 active site 290317001313 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290317001314 Membrane transport protein; Region: Mem_trans; cl09117 290317001315 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290317001316 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 290317001317 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290317001318 catalytic residues [active] 290317001319 Flagellin N-methylase; Region: FliB; cl00497 290317001320 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290317001321 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317001322 Walker A/P-loop; other site 290317001323 ATP binding site [chemical binding]; other site 290317001324 Q-loop/lid; other site 290317001325 ABC transporter signature motif; other site 290317001326 Walker B; other site 290317001327 D-loop; other site 290317001328 H-loop/switch region; other site 290317001329 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 290317001330 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290317001331 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290317001332 nucleotide binding pocket [chemical binding]; other site 290317001333 K-X-D-G motif; other site 290317001334 catalytic site [active] 290317001335 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290317001336 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290317001337 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290317001338 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290317001339 VanZ like family; Region: VanZ; cl01971 290317001340 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 290317001341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317001342 S-adenosylmethionine binding site [chemical binding]; other site 290317001343 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 290317001344 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317001345 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317001346 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317001347 Ferrochelatase; Region: Ferrochelatase; pfam00762 290317001348 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290317001349 C-terminal domain interface [polypeptide binding]; other site 290317001350 active site 290317001351 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290317001352 active site 290317001353 N-terminal domain interface [polypeptide binding]; other site 290317001354 Uncharacterized conserved protein [Function unknown]; Region: COG1432 290317001355 LabA_like proteins; Region: LabA; cd10911 290317001356 putative metal binding site [ion binding]; other site 290317001357 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 290317001358 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290317001359 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 290317001360 Walker A/P-loop; other site 290317001361 ATP binding site [chemical binding]; other site 290317001362 Q-loop/lid; other site 290317001363 ABC transporter signature motif; other site 290317001364 Walker B; other site 290317001365 D-loop; other site 290317001366 H-loop/switch region; other site 290317001367 Cobalt transport protein; Region: CbiQ; cl00463 290317001368 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 290317001369 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 290317001370 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 290317001371 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 290317001372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001373 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 290317001374 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 290317001375 FAD binding pocket [chemical binding]; other site 290317001376 FAD binding motif [chemical binding]; other site 290317001377 phosphate binding motif [ion binding]; other site 290317001378 beta-alpha-beta structure motif; other site 290317001379 NAD binding pocket [chemical binding]; other site 290317001380 Iron coordination center [ion binding]; other site 290317001381 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 290317001382 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290317001383 putative active site [active] 290317001384 oxyanion strand; other site 290317001385 catalytic triad [active] 290317001386 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290317001387 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 290317001388 catalytic residues [active] 290317001389 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 290317001390 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 290317001391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290317001392 RNA binding surface [nucleotide binding]; other site 290317001393 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 290317001394 active site 290317001395 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290317001396 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 290317001397 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 290317001398 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 290317001399 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 290317001400 aminodeoxychorismate synthase; Provisional; Region: PRK07508 290317001401 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290317001402 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 290317001403 homodimer interface [polypeptide binding]; other site 290317001404 substrate-cofactor binding pocket; other site 290317001405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317001406 catalytic residue [active] 290317001407 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 290317001408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290317001409 helix-hairpin-helix signature motif; other site 290317001410 substrate binding pocket [chemical binding]; other site 290317001411 active site 290317001412 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 290317001413 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 290317001414 putative RNA binding site [nucleotide binding]; other site 290317001415 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290317001416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317001417 motif II; other site 290317001418 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290317001419 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 290317001420 Walker A/P-loop; other site 290317001421 ATP binding site [chemical binding]; other site 290317001422 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 290317001423 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 290317001424 Q-loop/lid; other site 290317001425 ABC transporter signature motif; other site 290317001426 Walker B; other site 290317001427 D-loop; other site 290317001428 H-loop/switch region; other site 290317001429 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290317001430 dihydropteroate synthase; Region: DHPS; TIGR01496 290317001431 substrate binding pocket [chemical binding]; other site 290317001432 dimer interface [polypeptide binding]; other site 290317001433 inhibitor binding site; inhibition site 290317001434 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 290317001435 active site 290317001436 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290317001437 putative substrate binding region [chemical binding]; other site 290317001438 Haem-binding domain; Region: Haem_bd; pfam14376 290317001439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001440 Predicted transcriptional regulator [Transcription]; Region: COG1959 290317001441 Helix-turn-helix domains; Region: HTH; cl00088 290317001442 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 290317001443 4Fe-4S binding domain; Region: Fer4; cl02805 290317001444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317001445 TPR motif; other site 290317001446 binding surface 290317001447 hybrid cluster protein; Provisional; Region: PRK05290 290317001448 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290317001449 ACS interaction site; other site 290317001450 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 290317001451 hybrid metal cluster; other site 290317001452 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290317001453 active site 290317001454 8-oxo-dGMP binding site [chemical binding]; other site 290317001455 nudix motif; other site 290317001456 metal binding site [ion binding]; metal-binding site 290317001457 benzoate transport; Region: 2A0115; TIGR00895 290317001458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290317001459 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 290317001460 catalytic residue [active] 290317001461 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 290317001462 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290317001463 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290317001464 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290317001465 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 290317001466 pyruvate phosphate dikinase; Provisional; Region: PRK09279 290317001467 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290317001468 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 290317001469 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290317001470 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290317001471 TM-ABC transporter signature motif; other site 290317001472 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 290317001473 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 290317001474 conserved cys residue [active] 290317001475 Helix-turn-helix domains; Region: HTH; cl00088 290317001476 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 290317001477 Phospholipid methyltransferase; Region: PEMT; cl00763 290317001478 Isochorismatase family; Region: Isochorismatase; pfam00857 290317001479 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 290317001480 catalytic triad [active] 290317001481 dimer interface [polypeptide binding]; other site 290317001482 conserved cis-peptide bond; other site 290317001483 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 290317001484 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 290317001485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 290317001486 putative acyl-acceptor binding pocket; other site 290317001487 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290317001488 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290317001489 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317001490 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290317001491 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 290317001492 MPN+ (JAMM) motif; other site 290317001493 Zinc-binding site [ion binding]; other site 290317001494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290317001495 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 290317001496 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317001497 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290317001498 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290317001499 active site 290317001500 ribulose/triose binding site [chemical binding]; other site 290317001501 phosphate binding site [ion binding]; other site 290317001502 substrate (anthranilate) binding pocket [chemical binding]; other site 290317001503 product (indole) binding pocket [chemical binding]; other site 290317001504 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290317001505 substrate binding site [chemical binding]; other site 290317001506 hexamer interface [polypeptide binding]; other site 290317001507 metal binding site [ion binding]; metal-binding site 290317001508 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 290317001509 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 290317001510 Surface antigen; Region: Bac_surface_Ag; cl03097 290317001511 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 290317001512 Peptidase family M23; Region: Peptidase_M23; pfam01551 290317001513 DNA polymerase I; Provisional; Region: PRK05755 290317001514 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290317001515 active site 290317001516 metal binding site 1 [ion binding]; metal-binding site 290317001517 putative 5' ssDNA interaction site; other site 290317001518 metal binding site 3; metal-binding site 290317001519 metal binding site 2 [ion binding]; metal-binding site 290317001520 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290317001521 putative DNA binding site [nucleotide binding]; other site 290317001522 putative metal binding site [ion binding]; other site 290317001523 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 290317001524 active site 290317001525 catalytic site [active] 290317001526 substrate binding site [chemical binding]; other site 290317001527 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290317001528 active site 290317001529 DNA binding site [nucleotide binding] 290317001530 catalytic site [active] 290317001531 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 290317001532 Prephenate dehydratase; Region: PDT; pfam00800 290317001533 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290317001534 putative L-Phe binding site [chemical binding]; other site 290317001535 Transcriptional regulator; Region: Transcrip_reg; cl00361 290317001536 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 290317001537 active site 290317001538 putative DNA-binding cleft [nucleotide binding]; other site 290317001539 dimer interface [polypeptide binding]; other site 290317001540 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290317001541 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 290317001542 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 290317001543 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290317001544 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 290317001545 ligand binding site [chemical binding]; other site 290317001546 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290317001547 active site 290317001548 dimerization interface [polypeptide binding]; other site 290317001549 TspO/MBR family; Region: TspO_MBR; cl01379 290317001550 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290317001551 AMP-binding enzyme; Region: AMP-binding; cl15778 290317001552 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290317001553 peptide synthase; Provisional; Region: PRK12467 290317001554 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 290317001555 AMP-binding enzyme; Region: AMP-binding; cl15778 290317001556 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290317001557 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 290317001558 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 290317001559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290317001560 Coenzyme A binding pocket [chemical binding]; other site 290317001561 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290317001562 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 290317001563 acetyl-CoA synthetase; Provisional; Region: PRK00174 290317001564 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 290317001565 AMP-binding enzyme; Region: AMP-binding; cl15778 290317001566 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290317001567 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290317001568 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290317001569 HIGH motif; other site 290317001570 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290317001571 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290317001572 active site 290317001573 KMSKS motif; other site 290317001574 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290317001575 tRNA binding surface [nucleotide binding]; other site 290317001576 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 290317001577 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 290317001578 RNase E interface [polypeptide binding]; other site 290317001579 trimer interface [polypeptide binding]; other site 290317001580 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290317001581 RNase E interface [polypeptide binding]; other site 290317001582 trimer interface [polypeptide binding]; other site 290317001583 active site 290317001584 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290317001585 putative nucleic acid binding region [nucleotide binding]; other site 290317001586 G-X-X-G motif; other site 290317001587 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290317001588 RNA binding site [nucleotide binding]; other site 290317001589 domain interface; other site 290317001590 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 290317001591 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290317001592 active site 290317001593 ATP-binding site [chemical binding]; other site 290317001594 pantoate-binding site; other site 290317001595 HXXH motif; other site 290317001596 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 290317001597 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 290317001598 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 290317001599 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290317001600 Walker A/P-loop; other site 290317001601 ATP binding site [chemical binding]; other site 290317001602 Q-loop/lid; other site 290317001603 ABC transporter signature motif; other site 290317001604 Walker B; other site 290317001605 D-loop; other site 290317001606 H-loop/switch region; other site 290317001607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290317001608 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 290317001609 oligomer interface [polypeptide binding]; other site 290317001610 tandem repeat interface [polypeptide binding]; other site 290317001611 active site residues [active] 290317001612 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 290317001613 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 290317001614 tandem repeat interface [polypeptide binding]; other site 290317001615 oligomer interface [polypeptide binding]; other site 290317001616 active site residues [active] 290317001617 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 290317001618 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 290317001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317001620 Walker A motif; other site 290317001621 ATP binding site [chemical binding]; other site 290317001622 Walker B motif; other site 290317001623 arginine finger; other site 290317001624 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290317001625 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290317001626 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 290317001627 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 290317001628 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290317001629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317001630 S-adenosylmethionine binding site [chemical binding]; other site 290317001631 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290317001632 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290317001633 Int/Topo IB signature motif; other site 290317001634 active site 290317001635 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 290317001636 30S subunit binding site; other site 290317001637 HPr kinase/phosphorylase; Provisional; Region: PRK05428 290317001638 DRTGG domain; Region: DRTGG; cl12147 290317001639 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 290317001640 Hpr binding site; other site 290317001641 active site 290317001642 homohexamer subunit interaction site [polypeptide binding]; other site 290317001643 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290317001644 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 290317001645 peptide binding site [polypeptide binding]; other site 290317001646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290317001647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317001648 dimer interface [polypeptide binding]; other site 290317001649 conserved gate region; other site 290317001650 putative PBP binding loops; other site 290317001651 ABC-ATPase subunit interface; other site 290317001652 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290317001653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317001654 Walker A motif; other site 290317001655 ATP binding site [chemical binding]; other site 290317001656 Walker B motif; other site 290317001657 arginine finger; other site 290317001658 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290317001659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317001660 TPR motif; other site 290317001661 binding surface 290317001662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317001663 TPR motif; other site 290317001664 binding surface 290317001665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290317001666 TPR motif; other site 290317001667 binding surface 290317001668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317001669 TPR motif; other site 290317001670 binding surface 290317001671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290317001672 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 290317001673 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290317001674 dimer interface [polypeptide binding]; other site 290317001675 PYR/PP interface [polypeptide binding]; other site 290317001676 TPP binding site [chemical binding]; other site 290317001677 substrate binding site [chemical binding]; other site 290317001678 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290317001679 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 290317001680 Domain of unknown function; Region: EKR; cl11037 290317001681 4Fe-4S binding domain; Region: Fer4; cl02805 290317001682 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 290317001683 TPP-binding site [chemical binding]; other site 290317001684 dimer interface [polypeptide binding]; other site 290317001685 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290317001686 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 290317001687 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290317001688 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290317001689 lipoyl attachment site [posttranslational modification]; other site 290317001690 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 290317001691 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290317001692 tetramer interface [polypeptide binding]; other site 290317001693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317001694 catalytic residue [active] 290317001695 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290317001696 dihydrodipicolinate synthase; Region: dapA; TIGR00674 290317001697 dimer interface [polypeptide binding]; other site 290317001698 active site 290317001699 catalytic residue [active] 290317001700 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 290317001701 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 290317001702 Walker A/P-loop; other site 290317001703 ATP binding site [chemical binding]; other site 290317001704 Q-loop/lid; other site 290317001705 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 290317001706 ABC transporter signature motif; other site 290317001707 Walker B; other site 290317001708 D-loop; other site 290317001709 H-loop/switch region; other site 290317001710 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290317001711 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 290317001712 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290317001713 Ligand Binding Site [chemical binding]; other site 290317001714 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290317001715 RNA/DNA hybrid binding site [nucleotide binding]; other site 290317001716 active site 290317001717 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 290317001718 UbiA prenyltransferase family; Region: UbiA; cl00337 290317001719 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 290317001720 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290317001721 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290317001722 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290317001723 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290317001724 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 290317001725 active site 290317001726 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 290317001727 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 290317001728 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 290317001729 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317001730 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290317001731 homodimer interface [polypeptide binding]; other site 290317001732 substrate-cofactor binding pocket; other site 290317001733 catalytic residue [active] 290317001734 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 290317001735 active site 290317001736 ADP/pyrophosphate binding site [chemical binding]; other site 290317001737 allosteric effector site; other site 290317001738 dimerization interface [polypeptide binding]; other site 290317001739 fructose-1,6-bisphosphate binding site; other site 290317001740 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290317001741 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317001742 FtsX-like permease family; Region: FtsX; cl15850 290317001743 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 290317001744 homotrimer interaction site [polypeptide binding]; other site 290317001745 zinc binding site [ion binding]; other site 290317001746 CDP-binding sites; other site 290317001747 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 290317001748 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 290317001749 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 290317001750 heterodimer interface [polypeptide binding]; other site 290317001751 active site 290317001752 FMN binding site [chemical binding]; other site 290317001753 homodimer interface [polypeptide binding]; other site 290317001754 substrate binding site [chemical binding]; other site 290317001755 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317001756 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 290317001757 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 290317001758 putative active site [active] 290317001759 putative metal binding site [ion binding]; other site 290317001760 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290317001761 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290317001762 Ferritin-like domain; Region: Ferritin; pfam00210 290317001763 ferroxidase diiron center [ion binding]; other site 290317001764 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 290317001765 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290317001766 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290317001767 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 290317001768 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317001769 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290317001770 IMP binding site; other site 290317001771 dimer interface [polypeptide binding]; other site 290317001772 interdomain contacts; other site 290317001773 partial ornithine binding site; other site 290317001774 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 290317001775 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 290317001776 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 290317001777 dimerization interface [polypeptide binding]; other site 290317001778 active site 290317001779 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290317001780 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290317001781 dimer interface [polypeptide binding]; other site 290317001782 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290317001783 active site 290317001784 folate binding site [chemical binding]; other site 290317001785 DNA primase; Validated; Region: dnaG; PRK05667 290317001786 CHC2 zinc finger; Region: zf-CHC2; cl15369 290317001787 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290317001788 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290317001789 active site 290317001790 metal binding site [ion binding]; metal-binding site 290317001791 interdomain interaction site; other site 290317001792 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290317001793 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 290317001794 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 290317001795 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 290317001796 Gram-negative bacterial tonB protein; Region: TonB; cl10048 290317001797 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 290317001798 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 290317001799 acetylornithine aminotransferase; Provisional; Region: PRK02627 290317001800 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290317001801 inhibitor-cofactor binding pocket; inhibition site 290317001802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317001803 catalytic residue [active] 290317001804 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290317001805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317001807 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 290317001808 AIR carboxylase; Region: AIRC; cl00310 290317001809 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 290317001810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317001811 FeS/SAM binding site; other site 290317001812 HemN C-terminal domain; Region: HemN_C; pfam06969 290317001813 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290317001814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001815 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 290317001816 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290317001817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317001818 PAS fold; Region: PAS_3; pfam08447 290317001819 putative active site [active] 290317001820 heme pocket [chemical binding]; other site 290317001821 GAF domain; Region: GAF; cl15785 290317001822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317001823 dimer interface [polypeptide binding]; other site 290317001824 phosphorylation site [posttranslational modification] 290317001825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317001826 ATP binding site [chemical binding]; other site 290317001827 Mg2+ binding site [ion binding]; other site 290317001828 G-X-G motif; other site 290317001829 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290317001830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317001831 active site 290317001832 phosphorylation site [posttranslational modification] 290317001833 intermolecular recognition site; other site 290317001834 dimerization interface [polypeptide binding]; other site 290317001835 Response regulator receiver domain; Region: Response_reg; pfam00072 290317001836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317001837 active site 290317001838 phosphorylation site [posttranslational modification] 290317001839 intermolecular recognition site; other site 290317001840 dimerization interface [polypeptide binding]; other site 290317001841 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290317001842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317001843 Walker A/P-loop; other site 290317001844 ATP binding site [chemical binding]; other site 290317001845 Q-loop/lid; other site 290317001846 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290317001847 ABC transporter; Region: ABC_tran_2; pfam12848 290317001848 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290317001849 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290317001850 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317001851 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290317001852 E3 interaction surface; other site 290317001853 lipoyl attachment site [posttranslational modification]; other site 290317001854 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 290317001855 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317001856 Walker A/P-loop; other site 290317001857 ATP binding site [chemical binding]; other site 290317001858 Q-loop/lid; other site 290317001859 ABC transporter signature motif; other site 290317001860 Walker B; other site 290317001861 D-loop; other site 290317001862 H-loop/switch region; other site 290317001863 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317001864 FtsX-like permease family; Region: FtsX; cl15850 290317001865 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290317001866 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317001867 CoA-ligase; Region: Ligase_CoA; cl02894 290317001868 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290317001869 nucleoside/Zn binding site; other site 290317001870 dimer interface [polypeptide binding]; other site 290317001871 catalytic motif [active] 290317001872 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 290317001873 FMN binding site [chemical binding]; other site 290317001874 substrate binding site [chemical binding]; other site 290317001875 putative catalytic residue [active] 290317001876 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290317001877 catalytic core [active] 290317001878 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290317001879 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290317001880 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290317001881 active site 290317001882 dimer interface [polypeptide binding]; other site 290317001883 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290317001884 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290317001885 active site 290317001886 FMN binding site [chemical binding]; other site 290317001887 substrate binding site [chemical binding]; other site 290317001888 3Fe-4S cluster binding site [ion binding]; other site 290317001889 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290317001890 domain interface; other site 290317001891 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 290317001892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001893 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 290317001894 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290317001895 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 290317001896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317001897 Walker A motif; other site 290317001898 ATP binding site [chemical binding]; other site 290317001899 Walker B motif; other site 290317001900 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290317001901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317001902 ATP binding site [chemical binding]; other site 290317001903 putative Mg++ binding site [ion binding]; other site 290317001904 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290317001905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317001906 nucleotide binding region [chemical binding]; other site 290317001907 ATP-binding site [chemical binding]; other site 290317001908 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 290317001909 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 290317001910 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317001911 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290317001912 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 290317001913 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 290317001914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001915 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 290317001916 Protein of unknown function (DUF499); Region: DUF499; pfam04465 290317001917 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 290317001918 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 290317001919 Fic family protein [Function unknown]; Region: COG3177 290317001920 Fic/DOC family; Region: Fic; cl00960 290317001921 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317001922 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290317001923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317001924 Integrase core domain; Region: rve; cl01316 290317001925 transposase; Provisional; Region: PRK06526 290317001926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317001927 Walker A motif; other site 290317001928 ATP binding site [chemical binding]; other site 290317001929 Walker B motif; other site 290317001930 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290317001931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317001932 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 290317001933 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 290317001934 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 290317001935 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 290317001936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290317001937 non-specific DNA binding site [nucleotide binding]; other site 290317001938 salt bridge; other site 290317001939 sequence-specific DNA binding site [nucleotide binding]; other site 290317001940 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 290317001941 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290317001942 putative active site [active] 290317001943 putative metal binding site [ion binding]; other site 290317001944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317001945 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317001946 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290317001947 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 290317001948 Virulence protein [General function prediction only]; Region: COG3943 290317001949 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 290317001950 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290317001951 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290317001952 purine monophosphate binding site [chemical binding]; other site 290317001953 dimer interface [polypeptide binding]; other site 290317001954 putative catalytic residues [active] 290317001955 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 290317001956 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 290317001957 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 290317001958 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 290317001959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001960 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290317001961 iron-sulfur cluster [ion binding]; other site 290317001962 [2Fe-2S] cluster binding site [ion binding]; other site 290317001963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317001964 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290317001965 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290317001966 mce related protein; Region: MCE; pfam02470 290317001967 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 290317001968 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290317001969 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 290317001970 Walker A/P-loop; other site 290317001971 ATP binding site [chemical binding]; other site 290317001972 Q-loop/lid; other site 290317001973 ABC transporter signature motif; other site 290317001974 Walker B; other site 290317001975 D-loop; other site 290317001976 H-loop/switch region; other site 290317001977 Permease; Region: Permease; cl00510 290317001978 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290317001979 Bacitracin resistance protein BacA; Region: BacA; cl00858 290317001980 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290317001981 active site 290317001982 dimerization interface [polypeptide binding]; other site 290317001983 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 290317001984 active site 290317001985 hydrophilic channel; other site 290317001986 dimerization interface [polypeptide binding]; other site 290317001987 catalytic residues [active] 290317001988 active site lid [active] 290317001989 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 290317001990 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 290317001991 Walker A/P-loop; other site 290317001992 ATP binding site [chemical binding]; other site 290317001993 Q-loop/lid; other site 290317001994 ABC transporter signature motif; other site 290317001995 Walker B; other site 290317001996 D-loop; other site 290317001997 H-loop/switch region; other site 290317001998 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 290317001999 Smr domain; Region: Smr; cl02619 290317002000 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290317002001 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 290317002002 tetramer interfaces [polypeptide binding]; other site 290317002003 binuclear metal-binding site [ion binding]; other site 290317002004 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 290317002005 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 290317002006 TPP-binding site; other site 290317002007 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290317002008 PYR/PP interface [polypeptide binding]; other site 290317002009 dimer interface [polypeptide binding]; other site 290317002010 TPP binding site [chemical binding]; other site 290317002011 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290317002012 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 290317002013 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 290317002014 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 290317002015 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002016 Family description; Region: UvrD_C_2; cl15862 290317002017 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 290317002018 Flavoprotein; Region: Flavoprotein; cl08021 290317002019 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 290317002020 FMN binding site [chemical binding]; other site 290317002021 dimer interface [polypeptide binding]; other site 290317002022 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290317002023 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 290317002024 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290317002025 DTAP/Switch II; other site 290317002026 Switch I; other site 290317002027 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 290317002028 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 290317002029 NAD binding site [chemical binding]; other site 290317002030 homotetramer interface [polypeptide binding]; other site 290317002031 homodimer interface [polypeptide binding]; other site 290317002032 substrate binding site [chemical binding]; other site 290317002033 active site 290317002034 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 290317002035 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 290317002036 Pirin-related protein [General function prediction only]; Region: COG1741 290317002037 Cupin domain; Region: Cupin_2; cl09118 290317002038 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 290317002039 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 290317002040 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290317002041 putative active site [active] 290317002042 metal binding site [ion binding]; metal-binding site 290317002043 homodimer binding site [polypeptide binding]; other site 290317002044 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 290317002045 AMP binding site [chemical binding]; other site 290317002046 metal binding site [ion binding]; metal-binding site 290317002047 active site 290317002048 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 290317002049 DHH family; Region: DHH; pfam01368 290317002050 DHHA1 domain; Region: DHHA1; pfam02272 290317002051 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 290317002052 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 290317002053 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 290317002054 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290317002055 Ligand binding site; other site 290317002056 Putative Catalytic site; other site 290317002057 DXD motif; other site 290317002058 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 290317002059 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 290317002060 active site 290317002061 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290317002062 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290317002063 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290317002064 putative active site [active] 290317002065 putative substrate binding site [chemical binding]; other site 290317002066 putative cosubstrate binding site; other site 290317002067 catalytic site [active] 290317002068 Cation efflux family; Region: Cation_efflux; cl00316 290317002069 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290317002070 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 290317002071 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 290317002072 coenzyme F420 hydrogenase, subunit beta; Region: frhB; TIGR03289 290317002073 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 290317002074 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 290317002075 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317002076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002077 Walker A/P-loop; other site 290317002078 ATP binding site [chemical binding]; other site 290317002079 Q-loop/lid; other site 290317002080 ABC transporter signature motif; other site 290317002081 Walker B; other site 290317002082 D-loop; other site 290317002083 H-loop/switch region; other site 290317002084 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 290317002085 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317002086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002087 Walker A/P-loop; other site 290317002088 ATP binding site [chemical binding]; other site 290317002089 Q-loop/lid; other site 290317002090 ABC transporter signature motif; other site 290317002091 Walker B; other site 290317002092 D-loop; other site 290317002093 H-loop/switch region; other site 290317002094 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290317002095 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290317002096 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 290317002097 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 290317002098 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 290317002099 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 290317002100 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 290317002101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 290317002102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290317002103 catalytic residue [active] 290317002104 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 290317002105 active site 290317002106 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290317002107 active site 290317002108 lipoprotein signal peptidase; Provisional; Region: PRK14787 290317002109 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 290317002110 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290317002111 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290317002112 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290317002113 shikimate binding site; other site 290317002114 NAD(P) binding site [chemical binding]; other site 290317002115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002116 binding surface 290317002117 TPR motif; other site 290317002118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002119 binding surface 290317002120 TPR motif; other site 290317002121 TPR repeat; Region: TPR_11; pfam13414 290317002122 TPR repeat; Region: TPR_11; pfam13414 290317002123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002124 binding surface 290317002125 TPR motif; other site 290317002126 TPR repeat; Region: TPR_11; pfam13414 290317002127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002128 binding surface 290317002129 TPR motif; other site 290317002130 TPR repeat; Region: TPR_11; pfam13414 290317002131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002132 binding surface 290317002133 TPR motif; other site 290317002134 TPR repeat; Region: TPR_11; pfam13414 290317002135 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 290317002136 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290317002137 GIY-YIG motif/motif A; other site 290317002138 active site 290317002139 catalytic site [active] 290317002140 putative DNA binding site [nucleotide binding]; other site 290317002141 metal binding site [ion binding]; metal-binding site 290317002142 UvrB/uvrC motif; Region: UVR; pfam02151 290317002143 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290317002144 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 290317002145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317002146 putative substrate translocation pore; other site 290317002147 metabolite-proton symporter; Region: 2A0106; TIGR00883 290317002148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290317002149 Ligand Binding Site [chemical binding]; other site 290317002150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317002151 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317002152 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290317002153 nudix motif; other site 290317002154 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 290317002155 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 290317002156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290317002157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002158 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 290317002159 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 290317002160 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002161 Switch II region; other site 290317002162 G4 box; other site 290317002163 G5 box; other site 290317002164 Acylphosphatase; Region: Acylphosphatase; cl00551 290317002165 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 290317002166 HypF finger; Region: zf-HYPF; pfam07503 290317002167 HypF finger; Region: zf-HYPF; pfam07503 290317002168 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290317002169 HupF/HypC family; Region: HupF_HypC; cl00394 290317002170 Hydrogenase formation hypA family; Region: HypD; cl12072 290317002171 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 290317002172 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 290317002173 dimerization interface [polypeptide binding]; other site 290317002174 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 290317002175 ATP binding site [chemical binding]; other site 290317002176 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 290317002177 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290317002178 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 290317002179 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290317002180 ATP binding site [chemical binding]; other site 290317002181 substrate interface [chemical binding]; other site 290317002182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317002183 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290317002184 FeS/SAM binding site; other site 290317002185 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 290317002186 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290317002187 ThiS interaction site; other site 290317002188 putative active site [active] 290317002189 tetramer interface [polypeptide binding]; other site 290317002190 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290317002191 thiS-thiF/thiG interaction site; other site 290317002192 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 290317002193 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290317002194 homodimer interface [polypeptide binding]; other site 290317002195 substrate-cofactor binding pocket; other site 290317002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317002197 catalytic residue [active] 290317002198 MOSC domain; Region: MOSC; pfam03473 290317002199 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 290317002200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317002201 FeS/SAM binding site; other site 290317002202 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290317002203 Helix-turn-helix domains; Region: HTH; cl00088 290317002204 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 290317002205 TOBE domain; Region: TOBE_2; cl01440 290317002206 TOBE domain; Region: TOBE_2; cl01440 290317002207 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 290317002208 dimer interface [polypeptide binding]; other site 290317002209 [2Fe-2S] cluster binding site [ion binding]; other site 290317002210 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 290317002211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317002212 FeS/SAM binding site; other site 290317002213 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 290317002214 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290317002215 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 290317002216 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 290317002217 MoFe protein beta/alpha subunit interactions; other site 290317002218 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 290317002219 Beta subunit P cluster binding residues; other site 290317002220 MoFe protein beta subunit/Fe protein contacts; other site 290317002221 MoFe protein dimer/ dimer interactions; other site 290317002222 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 290317002223 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 290317002224 MoFe protein alpha/beta subunit interactions; other site 290317002225 Alpha subunit P cluster binding residues; other site 290317002226 FeMoco binding residues [chemical binding]; other site 290317002227 MoFe protein alpha subunit/Fe protein contacts; other site 290317002228 MoFe protein dimer/ dimer interactions; other site 290317002229 Nitrogen regulatory protein P-II; Region: P-II; cl00412 290317002230 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290317002231 Nitrogen regulatory protein P-II; Region: P-II; cl00412 290317002232 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290317002233 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 290317002234 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 290317002235 Nucleotide-binding sites [chemical binding]; other site 290317002236 Walker A motif; other site 290317002237 Switch I region of nucleotide binding site; other site 290317002238 Fe4S4 binding sites [ion binding]; other site 290317002239 Switch II region of nucleotide binding site; other site 290317002240 Cation efflux family; Region: Cation_efflux; cl00316 290317002241 Cation efflux family; Region: Cation_efflux; cl00316 290317002242 Cation efflux family; Region: Cation_efflux; cl00316 290317002243 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941 290317002244 TIR domain; Region: TIR_2; cl15770 290317002245 Cation efflux family; Region: Cation_efflux; cl00316 290317002246 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290317002247 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290317002248 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290317002249 metal binding site 2 [ion binding]; metal-binding site 290317002250 putative DNA binding helix; other site 290317002251 metal binding site 1 [ion binding]; metal-binding site 290317002252 dimer interface [polypeptide binding]; other site 290317002253 structural Zn2+ binding site [ion binding]; other site 290317002254 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 290317002255 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 290317002256 dimer interface [polypeptide binding]; other site 290317002257 active site 290317002258 heme binding site [chemical binding]; other site 290317002259 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 290317002260 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290317002261 Predicted permeases [General function prediction only]; Region: COG0701 290317002262 Predicted permease; Region: DUF318; pfam03773 290317002263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290317002264 dimerization interface [polypeptide binding]; other site 290317002265 putative DNA binding site [nucleotide binding]; other site 290317002266 putative Zn2+ binding site [ion binding]; other site 290317002267 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 290317002268 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 290317002269 short chain dehydrogenase; Provisional; Region: PRK07832 290317002270 classical (c) SDRs; Region: SDR_c; cd05233 290317002271 NAD(P) binding site [chemical binding]; other site 290317002272 active site 290317002273 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 290317002274 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 290317002275 classical (c) SDRs; Region: SDR_c; cd05233 290317002276 NAD(P) binding site [chemical binding]; other site 290317002277 active site 290317002278 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 290317002279 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 290317002280 active site 290317002281 FMN binding site [chemical binding]; other site 290317002282 substrate binding site [chemical binding]; other site 290317002283 putative catalytic residue [active] 290317002284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317002286 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 290317002287 active site 290317002288 NTP binding site [chemical binding]; other site 290317002289 metal binding triad [ion binding]; metal-binding site 290317002290 antibiotic binding site [chemical binding]; other site 290317002291 Protein of unknown function DUF86; Region: DUF86; cl01031 290317002292 Protein of unknown function DUF86; Region: DUF86; cl01031 290317002293 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290317002294 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 290317002295 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 290317002296 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002297 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290317002298 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 290317002299 Protein export membrane protein; Region: SecD_SecF; cl14618 290317002300 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 290317002301 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317002302 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317002303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290317002304 Helix-turn-helix domains; Region: HTH; cl00088 290317002305 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002306 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290317002307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002308 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 290317002309 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 290317002310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002311 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290317002312 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 290317002313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317002314 CHAT domain; Region: CHAT; cl02083 290317002315 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 290317002316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002317 Walker A motif; other site 290317002318 ATP binding site [chemical binding]; other site 290317002319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002320 binding surface 290317002321 TPR motif; other site 290317002322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002323 binding surface 290317002324 TPR motif; other site 290317002325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002326 binding surface 290317002327 TPR motif; other site 290317002328 CpXC protein; Region: CpXC; pfam14353 290317002329 CHAT domain; Region: CHAT; pfam12770 290317002330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002331 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290317002332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002333 binding surface 290317002334 TPR motif; other site 290317002335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290317002336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290317002337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002338 binding surface 290317002339 TPR motif; other site 290317002340 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290317002341 CheB methylesterase; Region: CheB_methylest; pfam01339 290317002342 CsbD-like; Region: CsbD; cl15799 290317002343 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317002344 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317002345 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 290317002346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317002347 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 290317002348 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 290317002349 rod shape-determining protein MreB; Provisional; Region: PRK13930 290317002350 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 290317002351 ATP binding site [chemical binding]; other site 290317002352 gelsolin binding site; other site 290317002353 profilin binding site; other site 290317002354 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290317002355 histidinol dehydrogenase; Region: hisD; TIGR00069 290317002356 NAD binding site [chemical binding]; other site 290317002357 dimerization interface [polypeptide binding]; other site 290317002358 product binding site; other site 290317002359 substrate binding site [chemical binding]; other site 290317002360 zinc binding site [ion binding]; other site 290317002361 catalytic residues [active] 290317002362 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 290317002363 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 290317002364 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 290317002365 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 290317002366 substrate binding site [chemical binding]; other site 290317002367 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 290317002368 substrate binding site [chemical binding]; other site 290317002369 ligand binding site [chemical binding]; other site 290317002370 Membrane transport protein; Region: Mem_trans; cl09117 290317002371 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290317002372 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290317002373 hinge; other site 290317002374 active site 290317002375 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290317002376 Peptidase family M23; Region: Peptidase_M23; pfam01551 290317002377 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290317002378 NAD synthase; Region: NAD_synthase; pfam02540 290317002379 homodimer interface [polypeptide binding]; other site 290317002380 NAD binding pocket [chemical binding]; other site 290317002381 ATP binding pocket [chemical binding]; other site 290317002382 Mg binding site [ion binding]; other site 290317002383 active-site loop [active] 290317002384 L-aspartate oxidase; Provisional; Region: PRK09077 290317002385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002386 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290317002387 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290317002388 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 290317002389 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290317002390 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290317002391 active site 290317002392 HIGH motif; other site 290317002393 dimer interface [polypeptide binding]; other site 290317002394 KMSKS motif; other site 290317002395 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290317002396 RNA binding surface [nucleotide binding]; other site 290317002397 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290317002398 SmpB-tmRNA interface; other site 290317002399 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290317002400 FAD binding domain; Region: FAD_binding_4; pfam01565 290317002401 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 290317002402 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290317002403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290317002404 rod shape-determining protein MreC; Region: MreC; pfam04085 290317002405 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290317002406 oligomerisation interface [polypeptide binding]; other site 290317002407 mobile loop; other site 290317002408 roof hairpin; other site 290317002409 Quinolinate synthetase A protein; Region: NadA; cl00420 290317002410 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290317002411 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317002412 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 290317002413 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290317002414 trimer interface [polypeptide binding]; other site 290317002415 active site 290317002416 chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058 290317002417 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 290317002418 Probable Catalytic site; other site 290317002419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317002420 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 290317002421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317002422 FeS/SAM binding site; other site 290317002423 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 290317002424 phytoene desaturase; Region: phytoene_desat; TIGR02731 290317002425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002426 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290317002427 Helix-turn-helix domains; Region: HTH; cl00088 290317002428 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 290317002429 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 290317002430 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290317002431 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 290317002432 Type III pantothenate kinase; Region: Pan_kinase; cl09130 290317002433 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290317002434 active site 290317002435 dimer interface [polypeptide binding]; other site 290317002436 metal binding site [ion binding]; metal-binding site 290317002437 shikimate kinase; Reviewed; Region: aroK; PRK00131 290317002438 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290317002439 ADP binding site [chemical binding]; other site 290317002440 magnesium binding site [ion binding]; other site 290317002441 putative shikimate binding site; other site 290317002442 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 290317002443 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002444 Family description; Region: UvrD_C_2; cl15862 290317002445 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290317002446 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290317002447 catalytic triad [active] 290317002448 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 290317002449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002450 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 290317002451 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 290317002452 structural tetrad; other site 290317002453 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 290317002454 FOG: WD40 repeat [General function prediction only]; Region: COG2319 290317002455 structural tetrad; other site 290317002456 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 290317002457 structural tetrad; other site 290317002458 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 290317002459 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290317002460 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317002461 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 290317002462 Walker A/P-loop; other site 290317002463 ATP binding site [chemical binding]; other site 290317002464 Q-loop/lid; other site 290317002465 ABC transporter signature motif; other site 290317002466 Walker B; other site 290317002467 D-loop; other site 290317002468 H-loop/switch region; other site 290317002469 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290317002470 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317002471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002472 Walker A/P-loop; other site 290317002473 ATP binding site [chemical binding]; other site 290317002474 Q-loop/lid; other site 290317002475 ABC transporter signature motif; other site 290317002476 Walker B; other site 290317002477 D-loop; other site 290317002478 H-loop/switch region; other site 290317002479 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 290317002480 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290317002481 putative active site [active] 290317002482 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 290317002483 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290317002484 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 290317002485 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 290317002486 active site 290317002487 catalytic residues [active] 290317002488 metal binding site [ion binding]; metal-binding site 290317002489 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 290317002490 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290317002491 substrate binding site [chemical binding]; other site 290317002492 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290317002493 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290317002494 substrate binding site [chemical binding]; other site 290317002495 ligand binding site [chemical binding]; other site 290317002496 2-isopropylmalate synthase; Validated; Region: PRK00915 290317002497 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 290317002498 active site 290317002499 catalytic residues [active] 290317002500 metal binding site [ion binding]; metal-binding site 290317002501 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 290317002502 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 290317002503 tartrate dehydrogenase; Provisional; Region: PRK08194 290317002504 ketol-acid reductoisomerase; Provisional; Region: PRK05479 290317002505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002506 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290317002507 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290317002508 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290317002509 putative valine binding site [chemical binding]; other site 290317002510 dimer interface [polypeptide binding]; other site 290317002511 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290317002512 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 290317002513 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290317002514 PYR/PP interface [polypeptide binding]; other site 290317002515 dimer interface [polypeptide binding]; other site 290317002516 TPP binding site [chemical binding]; other site 290317002517 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 290317002518 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290317002519 TPP-binding site [chemical binding]; other site 290317002520 dimer interface [polypeptide binding]; other site 290317002521 Dehydratase family; Region: ILVD_EDD; cl00340 290317002522 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 290317002523 Integral membrane protein DUF92; Region: DUF92; cl00793 290317002524 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 290317002525 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 290317002526 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 290317002527 Gram-negative bacterial tonB protein; Region: TonB; cl10048 290317002528 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 290317002529 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290317002530 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290317002531 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290317002532 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290317002533 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290317002534 ligand binding site [chemical binding]; other site 290317002535 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 290317002536 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290317002537 ligand binding site [chemical binding]; other site 290317002538 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 290317002539 Tetratricopeptide repeat; Region: TPR_6; pfam13174 290317002540 Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657 290317002541 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290317002542 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290317002543 putative dimer interface [polypeptide binding]; other site 290317002544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290317002545 dimerization interface [polypeptide binding]; other site 290317002546 putative DNA binding site [nucleotide binding]; other site 290317002547 putative Zn2+ binding site [ion binding]; other site 290317002548 Putative zinc-finger; Region: zf-HC2; cl15806 290317002549 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 290317002550 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290317002551 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290317002552 DNA binding residues [nucleotide binding] 290317002553 Transposase domain (DUF772); Region: DUF772; cl15789 290317002554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317002555 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317002556 carotene isomerase; Region: carot_isom; TIGR02730 290317002557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002559 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290317002560 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 290317002561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290317002563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290317002564 catalytic loop [active] 290317002565 iron binding site [ion binding]; other site 290317002566 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 290317002567 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 290317002568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317002569 ATP binding site [chemical binding]; other site 290317002570 putative Mg++ binding site [ion binding]; other site 290317002571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317002572 nucleotide binding region [chemical binding]; other site 290317002573 ATP-binding site [chemical binding]; other site 290317002574 TRCF domain; Region: TRCF; cl04088 290317002575 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290317002576 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 290317002577 Walker A/P-loop; other site 290317002578 ATP binding site [chemical binding]; other site 290317002579 Q-loop/lid; other site 290317002580 ABC transporter signature motif; other site 290317002581 Walker B; other site 290317002582 D-loop; other site 290317002583 H-loop/switch region; other site 290317002584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290317002585 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 290317002586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317002587 active site 290317002588 phosphorylation site [posttranslational modification] 290317002589 intermolecular recognition site; other site 290317002590 dimerization interface [polypeptide binding]; other site 290317002591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290317002592 DNA binding site [nucleotide binding] 290317002593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290317002594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317002595 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290317002596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317002597 dimer interface [polypeptide binding]; other site 290317002598 phosphorylation site [posttranslational modification] 290317002599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317002600 ATP binding site [chemical binding]; other site 290317002601 Mg2+ binding site [ion binding]; other site 290317002602 G-X-G motif; other site 290317002603 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290317002604 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 290317002605 nudix motif; other site 290317002606 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290317002607 catalytic triad [active] 290317002608 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 290317002609 LabA_like proteins; Region: LabA_like; cd06167 290317002610 putative metal binding site [ion binding]; other site 290317002611 LabA_like proteins; Region: LabA_like; cd06167 290317002612 putative metal binding site [ion binding]; other site 290317002613 MatE; Region: MatE; cl10513 290317002614 Haemolytic domain; Region: Haemolytic; cl00506 290317002615 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317002616 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 290317002617 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290317002618 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317002619 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317002620 TIR domain; Region: TIR_2; cl15770 290317002621 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290317002622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002623 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317002624 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317002625 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 290317002626 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 290317002627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317002628 ATP binding site [chemical binding]; other site 290317002629 putative Mg++ binding site [ion binding]; other site 290317002630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317002631 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290317002632 Walker A motif; other site 290317002633 ATP binding site [chemical binding]; other site 290317002634 Walker B motif; other site 290317002635 arginine finger; other site 290317002636 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317002637 TIR domain; Region: TIR_2; cl15770 290317002638 Uncharacterized conserved protein [Function unknown]; Region: COG1262 290317002639 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317002640 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290317002641 Protein of unknown function DUF45; Region: DUF45; cl00636 290317002642 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290317002643 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 290317002644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002645 Domain of unknown function (DUF296); Region: DUF296; cl00720 290317002646 TspO/MBR family; Region: TspO_MBR; cl01379 290317002647 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 290317002648 putative catalytic residues [active] 290317002649 Sulfate transporter family; Region: Sulfate_transp; cl15842 290317002650 putative transporter; Provisional; Region: PRK11660 290317002651 Sulfate transporter family; Region: Sulfate_transp; cl15842 290317002652 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290317002653 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 290317002654 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 290317002655 nucleotidyl binding site; other site 290317002656 metal binding site [ion binding]; metal-binding site 290317002657 Rubrerythrin [Energy production and conversion]; Region: COG1592 290317002658 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 290317002659 binuclear metal center [ion binding]; other site 290317002660 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 290317002661 iron binding site [ion binding]; other site 290317002662 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290317002663 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290317002664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002665 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290317002666 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290317002667 active site 290317002668 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317002669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317002670 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 290317002671 active site 290317002672 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 290317002673 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 290317002674 oligomerization interface [polypeptide binding]; other site 290317002675 active site 290317002676 NAD+ binding site [chemical binding]; other site 290317002677 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290317002678 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290317002679 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290317002680 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290317002681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317002682 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 290317002683 active site 290317002684 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290317002685 putative trimer interface [polypeptide binding]; other site 290317002686 putative CoA binding site [chemical binding]; other site 290317002687 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 290317002688 nudix motif; other site 290317002689 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290317002690 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290317002691 putative tRNA-binding site [nucleotide binding]; other site 290317002692 B3/4 domain; Region: B3_4; cl11458 290317002693 tRNA synthetase B5 domain; Region: B5; cl08394 290317002694 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290317002695 dimer interface [polypeptide binding]; other site 290317002696 motif 1; other site 290317002697 motif 3; other site 290317002698 motif 2; other site 290317002699 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 290317002700 Cell division protein ZapA; Region: ZapA; cl01146 290317002701 phosphodiesterase; Provisional; Region: PRK12704 290317002702 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 290317002703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290317002704 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 290317002705 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290317002706 putative active site pocket [active] 290317002707 4-fold oligomerization interface [polypeptide binding]; other site 290317002708 metal binding residues [ion binding]; metal-binding site 290317002709 3-fold/trimer interface [polypeptide binding]; other site 290317002710 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 290317002711 Preprotein translocase SecG subunit; Region: SecG; cl09123 290317002712 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 290317002713 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 290317002714 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317002716 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317002717 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290317002718 non-specific DNA binding site [nucleotide binding]; other site 290317002719 salt bridge; other site 290317002720 sequence-specific DNA binding site [nucleotide binding]; other site 290317002721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002722 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 290317002723 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 290317002724 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290317002725 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 290317002726 Domain of unknown function (DUF814); Region: DUF814; pfam05670 290317002727 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 290317002728 catalytic motif [active] 290317002729 Zn binding site [ion binding]; other site 290317002730 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 290317002731 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290317002732 catalytic motif [active] 290317002733 Zn binding site [ion binding]; other site 290317002734 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 290317002735 DoxX; Region: DoxX; cl00976 290317002736 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290317002737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002738 Walker A/P-loop; other site 290317002739 ATP binding site [chemical binding]; other site 290317002740 Q-loop/lid; other site 290317002741 ABC transporter signature motif; other site 290317002742 Walker B; other site 290317002743 D-loop; other site 290317002744 H-loop/switch region; other site 290317002745 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 290317002746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317002747 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290317002748 active site 290317002749 metal binding site [ion binding]; metal-binding site 290317002750 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 290317002751 dimer interface [polypeptide binding]; other site 290317002752 catalytic triad [active] 290317002753 peroxidatic and resolving cysteines [active] 290317002754 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 290317002755 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 290317002756 Lumazine binding domain; Region: Lum_binding; pfam00677 290317002757 Lumazine binding domain; Region: Lum_binding; pfam00677 290317002758 recombination factor protein RarA; Reviewed; Region: PRK13342 290317002759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317002760 Walker A motif; other site 290317002761 ATP binding site [chemical binding]; other site 290317002762 Walker B motif; other site 290317002763 arginine finger; other site 290317002764 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290317002765 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290317002766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317002767 S-adenosylmethionine binding site [chemical binding]; other site 290317002768 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 290317002769 nucleotide binding site/active site [active] 290317002770 HIT family signature motif; other site 290317002771 catalytic residue [active] 290317002772 Ferrochelatase; Region: Ferrochelatase; pfam00762 290317002773 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290317002774 C-terminal domain interface [polypeptide binding]; other site 290317002775 active site 290317002776 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290317002777 active site 290317002778 N-terminal domain interface [polypeptide binding]; other site 290317002779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002780 TPR motif; other site 290317002781 TPR repeat; Region: TPR_11; pfam13414 290317002782 binding surface 290317002783 TPR repeat; Region: TPR_11; pfam13414 290317002784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317002785 binding surface 290317002786 TPR motif; other site 290317002787 TPR repeat; Region: TPR_11; pfam13414 290317002788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290317002789 binding surface 290317002790 TPR motif; other site 290317002791 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 290317002792 NADH dehydrogenase subunit B; Provisional; Region: PRK14813 290317002793 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 290317002794 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 290317002795 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 290317002796 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 290317002797 NADH dehydrogenase; Region: NADHdh; cl00469 290317002798 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 290317002799 4Fe-4S binding domain; Region: Fer4; cl02805 290317002800 4Fe-4S binding domain; Region: Fer4; cl02805 290317002801 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 290317002802 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 290317002803 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 290317002804 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 290317002805 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 290317002806 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 290317002807 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 290317002808 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 290317002809 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 290317002810 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 290317002811 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 290317002812 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 290317002813 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 290317002814 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 290317002815 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290317002816 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 290317002817 nickel binding site [ion binding]; other site 290317002818 putative substrate-binding site; other site 290317002819 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 290317002820 homodecamer interface [polypeptide binding]; other site 290317002821 GTP cyclohydrolase I; Provisional; Region: PLN03044 290317002822 active site 290317002823 putative catalytic site residues [active] 290317002824 zinc binding site [ion binding]; other site 290317002825 GTP-CH-I/GFRP interaction surface; other site 290317002826 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290317002827 active site 290317002828 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 290317002829 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 290317002830 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317002831 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 290317002832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317002833 S-adenosylmethionine binding site [chemical binding]; other site 290317002834 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 290317002835 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 290317002836 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290317002837 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290317002838 dephospho-CoA kinase; Provisional; Region: coaE; PRK14731 290317002839 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290317002840 CoA-binding site [chemical binding]; other site 290317002841 ATP-binding [chemical binding]; other site 290317002842 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317002843 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 290317002844 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290317002845 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290317002846 substrate binding pocket [chemical binding]; other site 290317002847 chain length determination region; other site 290317002848 substrate-Mg2+ binding site; other site 290317002849 catalytic residues [active] 290317002850 aspartate-rich region 1; other site 290317002851 active site lid residues [active] 290317002852 aspartate-rich region 2; other site 290317002853 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290317002854 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 290317002855 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290317002856 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 290317002857 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290317002858 TM-ABC transporter signature motif; other site 290317002859 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 290317002860 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 290317002861 Walker A/P-loop; other site 290317002862 ATP binding site [chemical binding]; other site 290317002863 Q-loop/lid; other site 290317002864 ABC transporter signature motif; other site 290317002865 Walker B; other site 290317002866 D-loop; other site 290317002867 H-loop/switch region; other site 290317002868 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 290317002869 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 290317002870 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290317002871 putative NAD(P) binding site [chemical binding]; other site 290317002872 Membrane protein of unknown function; Region: DUF360; cl00850 290317002873 DNA repair protein RadA; Provisional; Region: PRK11823 290317002874 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 290317002875 Walker A motif/ATP binding site; other site 290317002876 ATP binding site [chemical binding]; other site 290317002877 Walker B motif; other site 290317002878 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 290317002879 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174 290317002880 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290317002881 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290317002882 homodimer interface [polypeptide binding]; other site 290317002883 NADP binding site [chemical binding]; other site 290317002884 substrate binding site [chemical binding]; other site 290317002885 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 290317002886 homotrimer interface [polypeptide binding]; other site 290317002887 Walker A motif; other site 290317002888 GTP binding site [chemical binding]; other site 290317002889 Walker B motif; other site 290317002890 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 290317002891 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 290317002892 putative dimer interface [polypeptide binding]; other site 290317002893 active site pocket [active] 290317002894 putative cataytic base [active] 290317002895 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 290317002896 OsmC-like protein; Region: OsmC; cl00767 290317002897 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 290317002898 gating phenylalanine in ion channel; other site 290317002899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 290317002900 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 290317002901 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290317002902 putative active site [active] 290317002903 metal binding site [ion binding]; metal-binding site 290317002904 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 290317002905 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290317002906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317002907 Walker A/P-loop; other site 290317002908 ATP binding site [chemical binding]; other site 290317002909 Q-loop/lid; other site 290317002910 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290317002911 ABC transporter signature motif; other site 290317002912 Walker B; other site 290317002913 D-loop; other site 290317002914 ABC transporter; Region: ABC_tran_2; pfam12848 290317002915 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 290317002916 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 290317002917 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290317002918 active site 290317002919 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 290317002920 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317002921 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 290317002922 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290317002923 active site 290317002924 HIGH motif; other site 290317002925 KMSKS motif; other site 290317002926 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290317002927 tRNA binding surface [nucleotide binding]; other site 290317002928 anticodon binding site; other site 290317002929 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 290317002930 dimer interface [polypeptide binding]; other site 290317002931 putative tRNA-binding site [nucleotide binding]; other site 290317002932 PSP1 C-terminal conserved region; Region: PSP1; cl00770 290317002933 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 290317002934 putative acyl-acceptor binding pocket; other site 290317002935 aspartate aminotransferase; Provisional; Region: PRK05764 290317002936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290317002937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317002938 homodimer interface [polypeptide binding]; other site 290317002939 catalytic residue [active] 290317002940 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290317002941 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290317002942 active site 290317002943 (T/H)XGH motif; other site 290317002944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317002945 S-adenosylmethionine binding site [chemical binding]; other site 290317002946 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290317002947 TPP-binding site [chemical binding]; other site 290317002948 dimer interface [polypeptide binding]; other site 290317002949 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290317002950 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290317002951 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 290317002952 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 290317002953 ATP binding site [chemical binding]; other site 290317002954 active site 290317002955 substrate binding site [chemical binding]; other site 290317002956 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290317002957 putative catalytic site [active] 290317002958 putative metal binding site [ion binding]; other site 290317002959 putative phosphate binding site [ion binding]; other site 290317002960 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 290317002961 TfoX N-terminal domain; Region: TfoX_N; cl01167 290317002962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317002963 putative active site [active] 290317002964 heme pocket [chemical binding]; other site 290317002965 Helix-turn-helix domains; Region: HTH; cl00088 290317002966 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 290317002967 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290317002968 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290317002969 active site 290317002970 DNA binding site [nucleotide binding] 290317002971 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290317002972 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290317002973 Catalytic site [active] 290317002974 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290317002975 putative acyl-acceptor binding pocket; other site 290317002976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290317002977 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 290317002978 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290317002979 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 290317002980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317002981 dimer interface [polypeptide binding]; other site 290317002982 conserved gate region; other site 290317002983 putative PBP binding loops; other site 290317002984 ABC-ATPase subunit interface; other site 290317002985 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 290317002986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317002987 dimer interface [polypeptide binding]; other site 290317002988 conserved gate region; other site 290317002989 putative PBP binding loops; other site 290317002990 ABC-ATPase subunit interface; other site 290317002991 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275 290317002992 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 290317002993 Walker A/P-loop; other site 290317002994 ATP binding site [chemical binding]; other site 290317002995 Q-loop/lid; other site 290317002996 ABC transporter signature motif; other site 290317002997 Walker B; other site 290317002998 D-loop; other site 290317002999 H-loop/switch region; other site 290317003000 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290317003001 PhoU domain; Region: PhoU; pfam01895 290317003002 PhoU domain; Region: PhoU; pfam01895 290317003003 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290317003004 PhoU domain; Region: PhoU; pfam01895 290317003005 PhoU domain; Region: PhoU; pfam01895 290317003006 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317003007 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317003008 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290317003009 DoxX-like family; Region: DoxX_3; pfam13781 290317003010 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003011 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290317003012 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003013 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290317003014 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003016 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290317003017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317003019 active site 290317003020 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290317003021 classical (c) SDRs; Region: SDR_c; cd05233 290317003022 NAD(P) binding site [chemical binding]; other site 290317003023 active site 290317003024 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 290317003025 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 290317003026 Predicted permease [General function prediction only]; Region: COG2056 290317003027 RmuC family; Region: RmuC; pfam02646 290317003028 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 290317003029 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 290317003030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003031 Walker A motif; other site 290317003032 ATP binding site [chemical binding]; other site 290317003033 Walker B motif; other site 290317003034 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290317003035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003037 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 290317003038 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 290317003039 active site 290317003040 catalytic residues [active] 290317003041 metal binding site [ion binding]; metal-binding site 290317003042 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290317003043 carboxyltransferase (CT) interaction site; other site 290317003044 biotinylation site [posttranslational modification]; other site 290317003045 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290317003046 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290317003047 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 290317003048 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 290317003049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003050 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 290317003051 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 290317003052 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317003053 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290317003054 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290317003055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317003057 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 290317003058 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 290317003059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317003060 S-adenosylmethionine binding site [chemical binding]; other site 290317003061 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 290317003062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317003063 S-adenosylmethionine binding site [chemical binding]; other site 290317003064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317003065 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317003066 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290317003067 anti sigma factor interaction site; other site 290317003068 regulatory phosphorylation site [posttranslational modification]; other site 290317003069 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290317003070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003071 Maf-like protein; Region: Maf; pfam02545 290317003072 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290317003073 active site 290317003074 dimer interface [polypeptide binding]; other site 290317003075 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290317003076 Sodium:solute symporter family; Region: SSF; cl00456 290317003077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290317003078 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 290317003079 substrate binding site [chemical binding]; other site 290317003080 ATP binding site [chemical binding]; other site 290317003081 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290317003082 active site 290317003083 catalytic site [active] 290317003084 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290317003085 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 290317003086 dimerization interface 3.5A [polypeptide binding]; other site 290317003087 active site 290317003088 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 290317003089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 290317003090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290317003091 catalytic residue [active] 290317003092 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290317003093 putative peptidoglycan binding site; other site 290317003094 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290317003095 putative peptidoglycan binding site; other site 290317003096 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 290317003097 putative peptidoglycan binding site; other site 290317003098 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290317003099 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290317003100 P loop; other site 290317003101 Nucleotide binding site [chemical binding]; other site 290317003102 DTAP/Switch II; other site 290317003103 Switch I; other site 290317003104 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 290317003105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003106 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 290317003107 L-serine binding site [chemical binding]; other site 290317003108 NeuB family; Region: NeuB; cl00496 290317003109 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290317003110 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 290317003111 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 290317003112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290317003113 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 290317003114 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290317003115 active site 290317003116 dimer interface [polypeptide binding]; other site 290317003117 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 290317003118 dimer interface [polypeptide binding]; other site 290317003119 active site 290317003120 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290317003121 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317003122 FtsX-like permease family; Region: FtsX; cl15850 290317003123 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290317003124 active site 290317003125 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290317003126 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317003127 Walker A/P-loop; other site 290317003128 ATP binding site [chemical binding]; other site 290317003129 Q-loop/lid; other site 290317003130 ABC transporter signature motif; other site 290317003131 Walker B; other site 290317003132 D-loop; other site 290317003133 H-loop/switch region; other site 290317003134 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290317003135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003136 NAD(P) binding site [chemical binding]; other site 290317003137 active site 290317003138 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290317003139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003140 NAD(P) binding site [chemical binding]; other site 290317003141 active site 290317003142 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 290317003143 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290317003144 dimer interface [polypeptide binding]; other site 290317003145 active site 290317003146 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290317003147 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290317003148 active site 290317003149 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290317003150 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 290317003151 adenylosuccinate lyase; Provisional; Region: PRK07492 290317003152 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 290317003153 tetramer interface [polypeptide binding]; other site 290317003154 active site 290317003155 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 290317003156 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 290317003157 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290317003158 active site 290317003159 NTP binding site [chemical binding]; other site 290317003160 metal binding triad [ion binding]; metal-binding site 290317003161 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290317003162 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290317003163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290317003164 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290317003165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317003167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290317003168 putative substrate translocation pore; other site 290317003169 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 290317003170 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 290317003171 cobalamin binding residues [chemical binding]; other site 290317003172 putative BtuC binding residues; other site 290317003173 dimer interface [polypeptide binding]; other site 290317003174 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 290317003175 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290317003176 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290317003177 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 290317003178 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290317003179 N-terminal plug; other site 290317003180 ligand-binding site [chemical binding]; other site 290317003181 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 290317003182 putative FMN binding site [chemical binding]; other site 290317003183 cobyric acid synthase; Provisional; Region: PRK00784 290317003184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003185 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003186 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 290317003187 catalytic triad [active] 290317003188 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 290317003189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290317003190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317003191 homodimer interface [polypeptide binding]; other site 290317003192 catalytic residue [active] 290317003193 CobD/Cbib protein; Region: CobD_Cbib; cl00561 290317003194 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 290317003195 Walker A motif; other site 290317003196 homodimer interface [polypeptide binding]; other site 290317003197 ATP binding site [chemical binding]; other site 290317003198 hydroxycobalamin binding site [chemical binding]; other site 290317003199 Walker B motif; other site 290317003200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290317003201 ABC-ATPase subunit interface; other site 290317003202 dimer interface [polypeptide binding]; other site 290317003203 putative PBP binding regions; other site 290317003204 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290317003205 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290317003206 Walker A/P-loop; other site 290317003207 ATP binding site [chemical binding]; other site 290317003208 Q-loop/lid; other site 290317003209 ABC transporter signature motif; other site 290317003210 Walker B; other site 290317003211 D-loop; other site 290317003212 H-loop/switch region; other site 290317003213 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290317003214 Metal-binding active site; metal-binding site 290317003215 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 290317003216 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290317003217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317003218 ATP binding site [chemical binding]; other site 290317003219 putative Mg++ binding site [ion binding]; other site 290317003220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317003221 nucleotide binding region [chemical binding]; other site 290317003222 ATP-binding site [chemical binding]; other site 290317003223 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 290317003224 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 290317003225 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290317003226 Helix-turn-helix domains; Region: HTH; cl00088 290317003227 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 290317003228 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 290317003229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317003230 ATP binding site [chemical binding]; other site 290317003231 putative Mg++ binding site [ion binding]; other site 290317003232 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317003233 Divergent AAA domain; Region: AAA_4; pfam04326 290317003234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290317003235 HsdM N-terminal domain; Region: HsdM_N; pfam12161 290317003236 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290317003237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003238 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 290317003239 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317003240 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317003241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317003242 Integrase core domain; Region: rve; cl01316 290317003243 transposase; Provisional; Region: PRK06526 290317003244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003245 Walker A motif; other site 290317003246 ATP binding site [chemical binding]; other site 290317003247 Walker B motif; other site 290317003248 Protein of unknown function (DUF3532); Region: DUF3532; pfam12050 290317003249 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290317003250 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317003251 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290317003252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317003253 motif II; other site 290317003254 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 290317003255 Helix-turn-helix domains; Region: HTH; cl00088 290317003256 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 290317003257 Predicted transcriptional regulator [Transcription]; Region: COG5340 290317003258 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317003259 Helix-turn-helix domains; Region: HTH; cl00088 290317003260 BRO family, N-terminal domain; Region: Bro-N; cl10591 290317003261 Winged helix-turn helix; Region: HTH_29; pfam13551 290317003262 Helix-turn-helix domains; Region: HTH; cl00088 290317003263 Winged helix-turn helix; Region: HTH_33; pfam13592 290317003264 Integrase core domain; Region: rve; cl01316 290317003265 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290317003266 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290317003267 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 290317003268 classical (c) SDRs; Region: SDR_c; cd05233 290317003269 NAD(P) binding site [chemical binding]; other site 290317003270 active site 290317003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317003272 S-adenosylmethionine binding site [chemical binding]; other site 290317003273 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 290317003274 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 290317003275 active site residues [active] 290317003276 dimer interface [polypeptide binding]; other site 290317003277 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 290317003278 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290317003279 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290317003280 Ligand Binding Site [chemical binding]; other site 290317003281 membrane ATPase/protein kinase; Provisional; Region: PRK09435 290317003282 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 290317003283 Walker A; other site 290317003284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003285 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 290317003286 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 290317003287 active site 290317003288 substrate binding site [chemical binding]; other site 290317003289 coenzyme B12 binding site [chemical binding]; other site 290317003290 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 290317003291 B12 binding site [chemical binding]; other site 290317003292 cobalt ligand [ion binding]; other site 290317003293 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 290317003294 heterodimer interface [polypeptide binding]; other site 290317003295 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 290317003296 substrate interaction site [chemical binding]; other site 290317003297 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290317003298 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290317003299 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290317003300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290317003301 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 290317003302 dimer interface [polypeptide binding]; other site 290317003303 substrate binding site [chemical binding]; other site 290317003304 metal binding site [ion binding]; metal-binding site 290317003305 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 290317003306 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 290317003307 AMP-binding enzyme; Region: AMP-binding; cl15778 290317003308 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290317003309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003310 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290317003311 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290317003312 PYR/PP interface [polypeptide binding]; other site 290317003313 dimer interface [polypeptide binding]; other site 290317003314 TPP binding site [chemical binding]; other site 290317003315 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290317003316 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 290317003317 recombination protein RecR; Reviewed; Region: recR; PRK00076 290317003318 RecR protein; Region: RecR; pfam02132 290317003319 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290317003320 putative active site [active] 290317003321 putative metal-binding site [ion binding]; other site 290317003322 tetramer interface [polypeptide binding]; other site 290317003323 Uncharacterized conserved protein [Function unknown]; Region: COG3349 290317003324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003325 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317003326 FeS/SAM binding site; other site 290317003327 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 290317003328 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 290317003329 G1 box; other site 290317003330 putative GEF interaction site [polypeptide binding]; other site 290317003331 GTP/Mg2+ binding site [chemical binding]; other site 290317003332 Switch I region; other site 290317003333 G2 box; other site 290317003334 G3 box; other site 290317003335 Switch II region; other site 290317003336 G4 box; other site 290317003337 G5 box; other site 290317003338 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 290317003339 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290317003340 membrane-bound complex binding site; other site 290317003341 hinge residues; other site 290317003342 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290317003343 substrate binding pocket [chemical binding]; other site 290317003344 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290317003345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317003346 dimer interface [polypeptide binding]; other site 290317003347 conserved gate region; other site 290317003348 putative PBP binding loops; other site 290317003349 ABC-ATPase subunit interface; other site 290317003350 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290317003351 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 290317003352 Walker A/P-loop; other site 290317003353 ATP binding site [chemical binding]; other site 290317003354 Q-loop/lid; other site 290317003355 ABC transporter signature motif; other site 290317003356 Walker B; other site 290317003357 D-loop; other site 290317003358 H-loop/switch region; other site 290317003359 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 290317003360 dimer interface [polypeptide binding]; other site 290317003361 substrate binding site [chemical binding]; other site 290317003362 metal binding sites [ion binding]; metal-binding site 290317003363 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 290317003364 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290317003365 Class II fumarases; Region: Fumarase_classII; cd01362 290317003366 active site 290317003367 tetramer interface [polypeptide binding]; other site 290317003368 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 290317003369 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317003370 pseudaminic acid synthase; Region: PseI; TIGR03586 290317003371 NeuB family; Region: NeuB; cl00496 290317003372 heat shock protein 90; Provisional; Region: PRK05218 290317003373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290317003374 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 290317003375 diiron binding motif [ion binding]; other site 290317003376 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 290317003377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 290317003378 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003379 AAA domain; Region: AAA_33; pfam13671 290317003380 active site 290317003381 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 290317003382 Fumarase C-terminus; Region: Fumerase_C; cl00795 290317003383 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 290317003384 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290317003385 active site 290317003386 catalytic residues [active] 290317003387 metal binding site [ion binding]; metal-binding site 290317003388 homodimer binding site [polypeptide binding]; other site 290317003389 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290317003390 carboxyltransferase (CT) interaction site; other site 290317003391 biotinylation site [posttranslational modification]; other site 290317003392 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 290317003393 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290317003394 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290317003395 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290317003396 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290317003397 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290317003398 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 290317003399 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290317003400 generic binding surface II; other site 290317003401 generic binding surface I; other site 290317003402 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290317003403 catalytic residues [active] 290317003404 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290317003405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317003407 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290317003408 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 290317003409 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 290317003410 putative active site [active] 290317003411 putative metal binding site [ion binding]; other site 290317003412 SdiA-regulated; Region: SdiA-regulated; cd09971 290317003413 putative active site [active] 290317003414 Surface antigen; Region: Bac_surface_Ag; cl03097 290317003415 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 290317003416 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 290317003417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290317003418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317003419 active site 290317003420 phosphorylation site [posttranslational modification] 290317003421 intermolecular recognition site; other site 290317003422 dimerization interface [polypeptide binding]; other site 290317003423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290317003424 DNA binding site [nucleotide binding] 290317003425 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 290317003426 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290317003427 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290317003428 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 290317003429 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290317003430 ligand binding site [chemical binding]; other site 290317003431 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290317003432 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 290317003433 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 290317003434 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 290317003435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003436 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 290317003437 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290317003438 Transposase, Mutator family; Region: Transposase_mut; pfam00872 290317003439 MULE transposase domain; Region: MULE; pfam10551 290317003440 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 290317003441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003443 Family description; Region: UvrD_C_2; cl15862 290317003444 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290317003445 putative active site [active] 290317003446 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 290317003447 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290317003448 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 290317003449 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290317003450 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290317003451 PemK-like protein; Region: PemK; cl00995 290317003452 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 290317003453 putative active site [active] 290317003454 Zn binding site [ion binding]; other site 290317003455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317003456 PAS fold; Region: PAS_3; pfam08447 290317003457 putative active site [active] 290317003458 heme pocket [chemical binding]; other site 290317003459 PAS domain S-box; Region: sensory_box; TIGR00229 290317003460 SNF2 Helicase protein; Region: DUF3670; pfam12419 290317003461 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 290317003462 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317003463 ATP binding site [chemical binding]; other site 290317003464 putative Mg++ binding site [ion binding]; other site 290317003465 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317003466 nucleotide binding region [chemical binding]; other site 290317003467 ATP-binding site [chemical binding]; other site 290317003468 SWIM zinc finger; Region: SWIM; cl15408 290317003469 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290317003470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317003471 motif II; other site 290317003472 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290317003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317003474 S-adenosylmethionine binding site [chemical binding]; other site 290317003475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290317003476 Helix-turn-helix domains; Region: HTH; cl00088 290317003477 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317003478 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317003479 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317003480 FtsX-like permease family; Region: FtsX; cl15850 290317003481 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290317003482 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317003483 Walker A/P-loop; other site 290317003484 ATP binding site [chemical binding]; other site 290317003485 Q-loop/lid; other site 290317003486 ABC transporter signature motif; other site 290317003487 Walker B; other site 290317003488 D-loop; other site 290317003489 H-loop/switch region; other site 290317003490 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290317003491 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 290317003492 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 290317003493 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 290317003494 Cl- selectivity filter; other site 290317003495 Cl- binding residues [ion binding]; other site 290317003496 pore gating glutamate residue; other site 290317003497 dimer interface [polypeptide binding]; other site 290317003498 FOG: CBS domain [General function prediction only]; Region: COG0517 290317003499 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 290317003500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317003501 PAS domain; Region: PAS_9; pfam13426 290317003502 Helix-turn-helix domains; Region: HTH; cl00088 290317003503 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290317003504 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290317003505 P loop; other site 290317003506 Nucleotide binding site [chemical binding]; other site 290317003507 DTAP/Switch II; other site 290317003508 Switch I; other site 290317003509 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F; Region: TcpF; pfam06340 290317003510 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 290317003511 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290317003512 ATP binding site [chemical binding]; other site 290317003513 Mg++ binding site [ion binding]; other site 290317003514 motif III; other site 290317003515 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317003516 nucleotide binding region [chemical binding]; other site 290317003517 ATP-binding site [chemical binding]; other site 290317003518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317003519 Helix-turn-helix domains; Region: HTH; cl00088 290317003520 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290317003521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317003522 active site 290317003523 phosphorylation site [posttranslational modification] 290317003524 intermolecular recognition site; other site 290317003525 dimerization interface [polypeptide binding]; other site 290317003526 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 290317003527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317003528 putative active site [active] 290317003529 heme pocket [chemical binding]; other site 290317003530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317003531 putative active site [active] 290317003532 heme pocket [chemical binding]; other site 290317003533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317003534 dimer interface [polypeptide binding]; other site 290317003535 phosphorylation site [posttranslational modification] 290317003536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317003537 ATP binding site [chemical binding]; other site 290317003538 Mg2+ binding site [ion binding]; other site 290317003539 G-X-G motif; other site 290317003540 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 290317003541 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 290317003542 FAD binding domain; Region: FAD_binding_4; pfam01565 290317003543 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 290317003544 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 290317003545 putative heme binding site [chemical binding]; other site 290317003546 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 290317003547 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 290317003548 FAD binding pocket [chemical binding]; other site 290317003549 FAD binding motif [chemical binding]; other site 290317003550 phosphate binding motif [ion binding]; other site 290317003551 beta-alpha-beta structure motif; other site 290317003552 NAD binding pocket [chemical binding]; other site 290317003553 Iron coordination center [ion binding]; other site 290317003554 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 290317003555 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 290317003556 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 290317003557 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 290317003558 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 290317003559 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 290317003560 Cysteine-rich domain; Region: CCG; pfam02754 290317003561 Cysteine-rich domain; Region: CCG; pfam02754 290317003562 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290317003563 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 290317003564 aminotransferase; Validated; Region: PRK08175 290317003565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290317003566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317003567 homodimer interface [polypeptide binding]; other site 290317003568 catalytic residue [active] 290317003569 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 290317003570 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290317003571 putative substrate binding site [chemical binding]; other site 290317003572 putative ATP binding site [chemical binding]; other site 290317003573 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 290317003574 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290317003575 dimerization interface [polypeptide binding]; other site 290317003576 ATP binding site [chemical binding]; other site 290317003577 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 290317003578 dimerization interface [polypeptide binding]; other site 290317003579 ATP binding site [chemical binding]; other site 290317003580 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 290317003581 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 290317003582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317003583 nucleotide binding region [chemical binding]; other site 290317003584 ATP-binding site [chemical binding]; other site 290317003585 SEC-C motif; Region: SEC-C; pfam02810 290317003586 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 290317003587 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290317003588 helix-hairpin-helix signature motif; other site 290317003589 substrate binding pocket [chemical binding]; other site 290317003590 active site 290317003591 Cytochrome c; Region: Cytochrom_C; cl11414 290317003592 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 290317003593 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290317003594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003595 NAD(P) binding pocket [chemical binding]; other site 290317003596 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 290317003597 RNA/DNA binding site [nucleotide binding]; other site 290317003598 RRM dimerization site [polypeptide binding]; other site 290317003599 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 290317003600 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290317003601 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290317003602 NAD(P) binding site [chemical binding]; other site 290317003603 putative active site [active] 290317003604 lipoyl synthase; Provisional; Region: PRK05481 290317003605 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 290317003606 FeS/SAM binding site; other site 290317003607 transposase; Provisional; Region: PRK06526 290317003608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003609 Walker A motif; other site 290317003610 ATP binding site [chemical binding]; other site 290317003611 Walker B motif; other site 290317003612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317003613 Integrase core domain; Region: rve; cl01316 290317003614 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290317003615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317003616 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290317003617 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317003618 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 290317003619 catalytic motif [active] 290317003620 Catalytic residue [active] 290317003621 Predicted transcriptional regulator [Transcription]; Region: COG2944 290317003622 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 290317003623 Abi-like protein; Region: Abi_2; cl01988 290317003624 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290317003625 HerA helicase [Replication, recombination, and repair]; Region: COG0433 290317003626 Domain of unknown function DUF87; Region: DUF87; pfam01935 290317003627 KTSC domain; Region: KTSC; pfam13619 290317003628 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290317003629 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290317003630 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290317003631 TIR domain; Region: TIR_2; cl15770 290317003632 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317003633 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 290317003634 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003635 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317003636 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290317003637 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290317003638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317003639 ATP binding site [chemical binding]; other site 290317003640 putative Mg++ binding site [ion binding]; other site 290317003641 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317003642 nucleotide binding region [chemical binding]; other site 290317003643 ATP-binding site [chemical binding]; other site 290317003644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003645 ATP binding site [chemical binding]; other site 290317003646 putative Mg++ binding site [ion binding]; other site 290317003647 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 290317003648 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003649 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 290317003650 carboxy-terminal protease; Provisional; Region: PRK11186 290317003651 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290317003652 protein binding site [polypeptide binding]; other site 290317003653 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290317003654 Catalytic dyad [active] 290317003655 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 290317003656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003657 ATP citrate (pro-S)-lyase; Region: PLN02522 290317003658 CoA-ligase; Region: Ligase_CoA; cl02894 290317003659 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 290317003660 active site 290317003661 oxalacetate binding site [chemical binding]; other site 290317003662 citrylCoA binding site [chemical binding]; other site 290317003663 coenzyme A binding site [chemical binding]; other site 290317003664 catalytic triad [active] 290317003665 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317003666 ATP citrate (pro-S)-lyase; Region: PLN02235 290317003667 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 290317003668 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 290317003669 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 290317003670 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 290317003671 Walker A/P-loop; other site 290317003672 ATP binding site [chemical binding]; other site 290317003673 Q-loop/lid; other site 290317003674 ABC transporter signature motif; other site 290317003675 Walker B; other site 290317003676 D-loop; other site 290317003677 H-loop/switch region; other site 290317003678 Domain of unknown function DUF87; Region: DUF87; pfam01935 290317003679 HerA helicase [Replication, recombination, and repair]; Region: COG0433 290317003680 MAEBL; Provisional; Region: PTZ00121 290317003681 Predicted membrane protein [Function unknown]; Region: COG2119 290317003682 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 290317003683 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 290317003684 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 290317003685 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290317003686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290317003687 Coenzyme A binding pocket [chemical binding]; other site 290317003688 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290317003689 Rubredoxin; Region: Rubredoxin; pfam00301 290317003690 iron binding site [ion binding]; other site 290317003691 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290317003692 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317003693 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290317003694 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317003695 FtsX-like permease family; Region: FtsX; cl15850 290317003696 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290317003697 metal binding site [ion binding]; metal-binding site 290317003698 active site 290317003699 I-site; other site 290317003700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290317003701 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290317003702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003703 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290317003704 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 290317003705 heterotetramer interface [polypeptide binding]; other site 290317003706 active site pocket [active] 290317003707 cleavage site 290317003708 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 290317003709 feedback inhibition sensing region; other site 290317003710 homohexameric interface [polypeptide binding]; other site 290317003711 nucleotide binding site [chemical binding]; other site 290317003712 N-acetyl-L-glutamate binding site [chemical binding]; other site 290317003713 ornithine carbamoyltransferase; Provisional; Region: PRK00779 290317003714 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290317003715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003716 Arginine repressor [Transcription]; Region: ArgR; COG1438 290317003717 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290317003718 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290317003719 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 290317003720 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 290317003721 ANP binding site [chemical binding]; other site 290317003722 Substrate Binding Site II [chemical binding]; other site 290317003723 Substrate Binding Site I [chemical binding]; other site 290317003724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003725 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290317003726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003727 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317003728 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 290317003729 argininosuccinate lyase; Provisional; Region: PRK00855 290317003730 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290317003731 active sites [active] 290317003732 tetramer interface [polypeptide binding]; other site 290317003733 carboxy-terminal protease; Provisional; Region: PRK11186 290317003734 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290317003735 protein binding site [polypeptide binding]; other site 290317003736 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290317003737 Catalytic dyad [active] 290317003738 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 290317003739 hypothetical protein; Provisional; Region: PRK08185 290317003740 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290317003741 intersubunit interface [polypeptide binding]; other site 290317003742 active site 290317003743 zinc binding site [ion binding]; other site 290317003744 Na+ binding site [ion binding]; other site 290317003745 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290317003746 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290317003747 metal binding site [ion binding]; metal-binding site 290317003748 dimer interface [polypeptide binding]; other site 290317003749 FOG: CBS domain [General function prediction only]; Region: COG0517 290317003750 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 290317003751 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 290317003752 polyphosphate kinase; Provisional; Region: PRK05443 290317003753 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290317003754 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290317003755 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 290317003756 putative domain interface [polypeptide binding]; other site 290317003757 putative active site [active] 290317003758 catalytic site [active] 290317003759 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 290317003760 putative domain interface [polypeptide binding]; other site 290317003761 putative active site [active] 290317003762 catalytic site [active] 290317003763 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 290317003764 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290317003765 dihydroorotase; Validated; Region: pyrC; PRK09357 290317003766 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290317003767 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 290317003768 active site 290317003769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317003770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317003771 S-adenosylmethionine binding site [chemical binding]; other site 290317003772 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 290317003773 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 290317003774 putative NADP binding site [chemical binding]; other site 290317003775 putative substrate binding site [chemical binding]; other site 290317003776 active site 290317003777 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 290317003778 ligand binding site [chemical binding]; other site 290317003779 CHAD domain; Region: CHAD; cl10506 290317003780 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290317003781 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290317003782 P-loop; other site 290317003783 Magnesium ion binding site [ion binding]; other site 290317003784 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290317003785 Magnesium ion binding site [ion binding]; other site 290317003786 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 290317003787 NlpC/P60 family; Region: NLPC_P60; cl11438 290317003788 transposase; Provisional; Region: PRK06526 290317003789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003790 Walker A motif; other site 290317003791 ATP binding site [chemical binding]; other site 290317003792 Walker B motif; other site 290317003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317003794 Integrase core domain; Region: rve; cl01316 290317003795 Cupin domain; Region: Cupin_2; cl09118 290317003796 Integrase core domain; Region: rve; cl01316 290317003797 Winged helix-turn helix; Region: HTH_29; pfam13551 290317003798 Winged helix-turn helix; Region: HTH_33; pfam13592 290317003799 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 290317003800 exonuclease subunit SbcC; Provisional; Region: PRK10246 290317003801 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 290317003802 Walker A/P-loop; other site 290317003803 ATP binding site [chemical binding]; other site 290317003804 Q-loop/lid; other site 290317003805 exonuclease subunit SbcC; Provisional; Region: PRK10246 290317003806 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 290317003807 ABC transporter signature motif; other site 290317003808 Walker B; other site 290317003809 D-loop; other site 290317003810 H-loop/switch region; other site 290317003811 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 290317003812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317003813 putative ADP-binding pocket [chemical binding]; other site 290317003814 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 290317003815 Winged helix-turn helix; Region: HTH_29; pfam13551 290317003816 Winged helix-turn helix; Region: HTH_33; pfam13592 290317003817 Integrase core domain; Region: rve; cl01316 290317003818 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 290317003819 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290317003820 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290317003821 exonuclease subunit SbcD; Provisional; Region: PRK10966 290317003822 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290317003823 active site 290317003824 metal binding site [ion binding]; metal-binding site 290317003825 DNA binding site [nucleotide binding] 290317003826 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290317003827 Ion channel; Region: Ion_trans_2; cl11596 290317003828 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 290317003829 YokU-like protein; Region: YokU; cl15819 290317003830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290317003831 non-specific DNA binding site [nucleotide binding]; other site 290317003832 salt bridge; other site 290317003833 sequence-specific DNA binding site [nucleotide binding]; other site 290317003834 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290317003835 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 290317003836 PemK-like protein; Region: PemK; cl00995 290317003837 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 290317003838 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 290317003839 Winged helix-turn helix; Region: HTH_29; pfam13551 290317003840 Winged helix-turn helix; Region: HTH_33; pfam13592 290317003841 Integrase core domain; Region: rve; cl01316 290317003842 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290317003843 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317003844 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290317003845 PemK-like protein; Region: PemK; cl00995 290317003846 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 290317003847 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317003848 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 290317003849 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 290317003850 putative active site [active] 290317003851 putative metal binding site [ion binding]; other site 290317003852 Coronavirus S1 glycoprotein; Region: Corona_S1; pfam01600 290317003853 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317003854 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 290317003855 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317003856 Divergent AAA domain; Region: AAA_4; pfam04326 290317003857 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290317003858 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 290317003859 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003860 Family description; Region: UvrD_C_2; cl15862 290317003861 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 290317003862 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 290317003863 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 290317003864 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 290317003865 Bacterial PH domain; Region: DUF304; cl01348 290317003866 Domain of unknown function (DUF389); Region: DUF389; cl00781 290317003867 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317003868 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 290317003869 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 290317003870 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290317003871 putative active site [active] 290317003872 catalytic residue [active] 290317003873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317003874 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317003875 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290317003876 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 290317003877 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290317003878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317003879 homodimer interface [polypeptide binding]; other site 290317003880 catalytic residue [active] 290317003881 RNA polymerase sigma factor; Provisional; Region: PRK11924 290317003882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 290317003883 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 290317003884 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 290317003885 NADP binding site [chemical binding]; other site 290317003886 homopentamer interface [polypeptide binding]; other site 290317003887 substrate binding site [chemical binding]; other site 290317003888 active site 290317003889 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003890 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 290317003891 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 290317003892 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 290317003893 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 290317003894 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290317003895 LysE type translocator; Region: LysE; cl00565 290317003896 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 290317003897 putative FMN binding site [chemical binding]; other site 290317003898 NADPH bind site [chemical binding]; other site 290317003899 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317003900 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 290317003901 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317003902 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290317003903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003904 Walker A motif; other site 290317003905 ATP binding site [chemical binding]; other site 290317003906 Walker B motif; other site 290317003907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317003908 Integrase core domain; Region: rve; cl01316 290317003909 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 290317003910 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 290317003911 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 290317003912 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 290317003913 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 290317003914 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 290317003915 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 290317003916 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 290317003917 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 290317003918 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 290317003919 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003920 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 290317003921 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 290317003922 Predicted transcriptional regulator [Transcription]; Region: COG2378 290317003923 WYL domain; Region: WYL; cl14852 290317003924 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290317003925 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 290317003926 YcfA-like protein; Region: YcfA; cl00752 290317003927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 290317003928 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 290317003929 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290317003930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 290317003931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317003932 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290317003933 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 290317003934 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 290317003935 UbiA prenyltransferase family; Region: UbiA; cl00337 290317003936 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290317003937 active site 290317003938 transposase; Provisional; Region: PRK06526 290317003939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003940 Walker A motif; other site 290317003941 ATP binding site [chemical binding]; other site 290317003942 Walker B motif; other site 290317003943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317003944 Integrase core domain; Region: rve; cl01316 290317003945 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290317003946 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290317003947 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 290317003948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317003949 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 290317003950 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 290317003951 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 290317003952 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 290317003953 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 290317003954 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 290317003955 catalytic residues [active] 290317003956 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 290317003957 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 290317003958 FAD binding pocket [chemical binding]; other site 290317003959 FAD binding motif [chemical binding]; other site 290317003960 phosphate binding motif [ion binding]; other site 290317003961 beta-alpha-beta structure motif; other site 290317003962 NAD binding pocket [chemical binding]; other site 290317003963 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 290317003964 putative hydrophobic ligand binding site [chemical binding]; other site 290317003965 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 290317003966 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 290317003967 FMN binding site [chemical binding]; other site 290317003968 dimer interface [polypeptide binding]; other site 290317003969 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290317003970 CoenzymeA binding site [chemical binding]; other site 290317003971 subunit interaction site [polypeptide binding]; other site 290317003972 PHB binding site; other site 290317003973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 290317003974 SEC-C motif; Region: SEC-C; pfam02810 290317003975 hypothetical protein; Provisional; Region: PRK07877 290317003976 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 290317003977 dimer interface [polypeptide binding]; other site 290317003978 Helix-turn-helix domains; Region: HTH; cl00088 290317003979 Helix-turn-helix domains; Region: HTH; cl00088 290317003980 Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431 290317003981 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 290317003982 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 290317003983 putative active site [active] 290317003984 putative NTP binding site [chemical binding]; other site 290317003985 putative nucleic acid binding site [nucleotide binding]; other site 290317003986 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 290317003987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317003988 Integrase core domain; Region: rve; cl01316 290317003989 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290317003990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317003991 Walker A motif; other site 290317003992 ATP binding site [chemical binding]; other site 290317003993 Walker B motif; other site 290317003994 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317003995 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 290317003996 putative NTP binding site [chemical binding]; other site 290317003997 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317003998 Helix-turn-helix domains; Region: HTH; cl00088 290317003999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317004000 ATP binding site [chemical binding]; other site 290317004001 Mg2+ binding site [ion binding]; other site 290317004002 G-X-G motif; other site 290317004003 aminotransferase; Validated; Region: PRK07678 290317004004 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 290317004005 Uncharacterized conserved protein [Function unknown]; Region: COG1262 290317004006 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317004007 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 290317004008 HsdM N-terminal domain; Region: HsdM_N; pfam12161 290317004009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004010 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 290317004011 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317004012 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317004013 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 290317004014 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 290317004015 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 290317004016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317004017 ATP binding site [chemical binding]; other site 290317004018 putative Mg++ binding site [ion binding]; other site 290317004019 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 290317004020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004021 XamI restriction endonuclease; Region: RE_XamI; pfam09572 290317004022 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 290317004023 Domain of unknown function (DUF955); Region: DUF955; cl01076 290317004024 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317004025 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004026 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290317004027 FtsX-like permease family; Region: FtsX; cl15850 290317004028 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290317004029 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317004030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290317004031 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317004032 Walker A/P-loop; other site 290317004033 ATP binding site [chemical binding]; other site 290317004034 Q-loop/lid; other site 290317004035 ABC transporter signature motif; other site 290317004036 Walker B; other site 290317004037 D-loop; other site 290317004038 H-loop/switch region; other site 290317004039 Spore germination protein; Region: Spore_permease; cl15802 290317004040 amino acid transporter; Region: 2A0306; TIGR00909 290317004041 Spore germination protein; Region: Spore_permease; cl15802 290317004042 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 290317004043 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290317004044 FAD binding domain; Region: FAD_binding_4; pfam01565 290317004045 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 290317004046 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290317004047 Cysteine-rich domain; Region: CCG; pfam02754 290317004048 Cysteine-rich domain; Region: CCG; pfam02754 290317004049 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290317004050 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290317004051 inhibitor-cofactor binding pocket; inhibition site 290317004052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317004053 catalytic residue [active] 290317004054 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290317004055 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290317004056 active site 290317004057 NAD binding site [chemical binding]; other site 290317004058 metal binding site [ion binding]; metal-binding site 290317004059 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 290317004060 ligand binding site; other site 290317004061 tetramer interface; other site 290317004062 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317004063 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 290317004064 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 290317004065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 290317004066 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290317004067 AMP-binding enzyme; Region: AMP-binding; cl15778 290317004068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290317004069 endonuclease III; Region: ENDO3c; smart00478 290317004070 minor groove reading motif; other site 290317004071 helix-hairpin-helix signature motif; other site 290317004072 substrate binding pocket [chemical binding]; other site 290317004073 active site 290317004074 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 290317004075 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 290317004076 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 290317004077 RimM N-terminal domain; Region: RimM; pfam01782 290317004078 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 290317004079 signal recognition particle protein; Provisional; Region: PRK10867 290317004080 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 290317004081 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290317004082 P loop; other site 290317004083 GTP binding site [chemical binding]; other site 290317004084 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290317004085 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 290317004086 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290317004087 putative ribose interaction site [chemical binding]; other site 290317004088 putative ADP binding site [chemical binding]; other site 290317004089 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 290317004090 putative lipid binding site [chemical binding]; other site 290317004091 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 290317004092 putative lipid binding site [chemical binding]; other site 290317004093 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290317004094 C-terminal peptidase (prc); Region: prc; TIGR00225 290317004095 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290317004096 protein binding site [polypeptide binding]; other site 290317004097 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290317004098 Catalytic dyad [active] 290317004099 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290317004100 homotrimer interaction site [polypeptide binding]; other site 290317004101 putative active site [active] 290317004102 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290317004103 thiamine phosphate binding site [chemical binding]; other site 290317004104 active site 290317004105 pyrophosphate binding site [ion binding]; other site 290317004106 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290317004107 thiamine phosphate binding site [chemical binding]; other site 290317004108 active site 290317004109 pyrophosphate binding site [ion binding]; other site 290317004110 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290317004111 dimer interface [polypeptide binding]; other site 290317004112 substrate binding site [chemical binding]; other site 290317004113 ATP binding site [chemical binding]; other site 290317004114 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290317004115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004116 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290317004117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004118 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 290317004119 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 290317004120 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290317004121 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290317004122 interface (dimer of trimers) [polypeptide binding]; other site 290317004123 Substrate-binding/catalytic site; other site 290317004124 Zn-binding sites [ion binding]; other site 290317004125 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 290317004126 DHH family; Region: DHH; pfam01368 290317004127 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456 290317004128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317004129 FeS/SAM binding site; other site 290317004130 adenylate kinase; Reviewed; Region: adk; PRK00279 290317004131 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290317004132 AMP-binding site [chemical binding]; other site 290317004133 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290317004134 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 290317004135 primosome assembly protein PriA; Validated; Region: PRK05580 290317004136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317004137 ATP binding site [chemical binding]; other site 290317004138 putative Mg++ binding site [ion binding]; other site 290317004139 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004140 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290317004141 trimer interface [polypeptide binding]; other site 290317004142 active site 290317004143 dimer interface [polypeptide binding]; other site 290317004144 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 290317004145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317004147 Walker A motif; other site 290317004148 ATP binding site [chemical binding]; other site 290317004149 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004150 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290317004151 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 290317004152 active site 290317004153 HslU subunit interaction site [polypeptide binding]; other site 290317004154 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 290317004155 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 290317004156 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 290317004157 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 290317004158 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 290317004159 putative diguanylate cyclase; Provisional; Region: PRK09776 290317004160 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 290317004161 PAS domain S-box; Region: sensory_box; TIGR00229 290317004162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317004163 GAF domain; Region: GAF_2; pfam13185 290317004164 GAF domain; Region: GAF; cl15785 290317004165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317004166 dimer interface [polypeptide binding]; other site 290317004167 phosphorylation site [posttranslational modification] 290317004168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317004169 ATP binding site [chemical binding]; other site 290317004170 Mg2+ binding site [ion binding]; other site 290317004171 G-X-G motif; other site 290317004172 Response regulator receiver domain; Region: Response_reg; pfam00072 290317004173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004174 active site 290317004175 phosphorylation site [posttranslational modification] 290317004176 intermolecular recognition site; other site 290317004177 dimerization interface [polypeptide binding]; other site 290317004178 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 290317004179 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 290317004180 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 290317004181 Dicarboxylate transport; Region: DctA-YdbH; cl14674 290317004182 Dicarboxylate transport; Region: DctA-YdbH; cl14674 290317004183 Dicarboxylate transport; Region: DctA-YdbH; cl14674 290317004184 transposase; Provisional; Region: PRK06526 290317004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317004186 Walker A motif; other site 290317004187 ATP binding site [chemical binding]; other site 290317004188 Walker B motif; other site 290317004189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317004190 Integrase core domain; Region: rve; cl01316 290317004191 DinB superfamily; Region: DinB_2; pfam12867 290317004192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004193 flavoprotein, HI0933 family; Region: TIGR00275 290317004194 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290317004195 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 290317004196 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317004197 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004198 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004199 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 290317004200 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290317004201 DNA binding site [nucleotide binding] 290317004202 active site 290317004203 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 290317004204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317004205 binding surface 290317004206 TPR motif; other site 290317004207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317004208 binding surface 290317004209 TPR motif; other site 290317004210 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290317004211 FMN binding site [chemical binding]; other site 290317004212 active site 290317004213 substrate binding site [chemical binding]; other site 290317004214 catalytic residue [active] 290317004215 UbiA prenyltransferase family; Region: UbiA; cl00337 290317004216 Rubredoxin [Energy production and conversion]; Region: COG1773 290317004217 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290317004218 iron binding site [ion binding]; other site 290317004219 Rubredoxin; Region: Rubredoxin; pfam00301 290317004220 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290317004221 iron binding site [ion binding]; other site 290317004222 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290317004223 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 290317004224 active site 290317004225 FMN binding site [chemical binding]; other site 290317004226 substrate binding site [chemical binding]; other site 290317004227 3Fe-4S cluster binding site [ion binding]; other site 290317004228 Rubrerythrin [Energy production and conversion]; Region: COG1592 290317004229 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 290317004230 binuclear metal center [ion binding]; other site 290317004231 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 290317004232 iron binding site [ion binding]; other site 290317004233 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290317004234 active site 290317004235 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290317004236 putative substrate binding region [chemical binding]; other site 290317004237 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 290317004238 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 290317004239 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290317004240 active site residue [active] 290317004241 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290317004242 active site 290317004243 substrate binding site [chemical binding]; other site 290317004244 catalytic site [active] 290317004245 Protein of unknown function DUF89; Region: DUF89; cl15397 290317004246 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290317004247 Helix-turn-helix domains; Region: HTH; cl00088 290317004248 Peptidase family M48; Region: Peptidase_M48; cl12018 290317004249 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 290317004250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290317004251 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 290317004252 active site 290317004253 nucleophile elbow; other site 290317004254 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 290317004255 Protein of unknown function (DUF796); Region: DUF796; cl01226 290317004256 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 290317004257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290317004258 carboxyltransferase (CT) interaction site; other site 290317004259 biotinylation site [posttranslational modification]; other site 290317004260 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 290317004261 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290317004262 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290317004263 oxaloacetate decarboxylase; Provisional; Region: PRK12330 290317004264 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290317004265 active site 290317004266 metal binding site [ion binding]; metal-binding site 290317004267 homodimer binding site [polypeptide binding]; other site 290317004268 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 290317004269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317004270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317004271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317004272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290317004273 GTPase RsgA; Reviewed; Region: PRK01889 290317004274 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290317004275 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290317004276 GTP/Mg2+ binding site [chemical binding]; other site 290317004277 G4 box; other site 290317004278 G5 box; other site 290317004279 G1 box; other site 290317004280 Switch I region; other site 290317004281 G2 box; other site 290317004282 G3 box; other site 290317004283 Switch II region; other site 290317004284 Predicted acetyltransferase [General function prediction only]; Region: COG3153 290317004285 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 290317004286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290317004287 Coenzyme A binding pocket [chemical binding]; other site 290317004288 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 290317004289 Phage terminase large subunit; Region: Terminase_3; cl12054 290317004290 Terminase-like family; Region: Terminase_6; pfam03237 290317004291 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 290317004292 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 290317004293 putative homodimer interface [polypeptide binding]; other site 290317004294 putative active site [active] 290317004295 catalytic site [active] 290317004296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317004297 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 290317004298 ATP binding site [chemical binding]; other site 290317004299 putative Mg++ binding site [ion binding]; other site 290317004300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317004301 nucleotide binding region [chemical binding]; other site 290317004302 ATP-binding site [chemical binding]; other site 290317004303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004304 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 290317004305 PemK-like protein; Region: PemK; cl00995 290317004306 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 290317004307 P22 coat protein - gene protein 5; Region: P22_CoatProtein; cl10302 290317004308 Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787 290317004309 Restriction endonuclease; Region: Mrr_cat; cl00516 290317004310 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 290317004311 Mrr N-terminal domain; Region: Mrr_N; pfam14338 290317004312 Restriction endonuclease; Region: Mrr_cat; cl00516 290317004313 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 290317004314 putative uracil binding site [chemical binding]; other site 290317004315 putative active site [active] 290317004316 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 290317004317 MPN+ (JAMM) motif; other site 290317004318 Zinc-binding site [ion binding]; other site 290317004319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317004320 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 290317004321 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 290317004322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290317004323 integrase; Provisional; Region: PRK09692 290317004324 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290317004325 active site 290317004326 Int/Topo IB signature motif; other site 290317004327 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290317004328 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 290317004329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 290317004330 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 290317004331 active site 290317004332 magnesium chelatase, H subunit; Region: BchH; TIGR02025 290317004333 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290317004334 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290317004335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004336 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 290317004337 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 290317004338 metal ion-dependent adhesion site (MIDAS); other site 290317004339 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 290317004340 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004341 Walker A motif; other site 290317004342 ATP binding site [chemical binding]; other site 290317004343 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290317004344 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317004345 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290317004346 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290317004347 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290317004348 RNA binding surface [nucleotide binding]; other site 290317004349 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 290317004350 active site 290317004351 SET domain; Region: SET; cl02566 290317004352 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290317004353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004354 NAD(P) binding site [chemical binding]; other site 290317004355 active site 290317004356 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317004357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317004358 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290317004359 thymidylate kinase; Validated; Region: tmk; PRK00698 290317004360 TMP-binding site; other site 290317004361 ATP-binding site [chemical binding]; other site 290317004362 phosphoglycolate phosphatase; Provisional; Region: PRK01158 290317004363 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290317004364 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317004365 motif II; other site 290317004366 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290317004367 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290317004368 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290317004369 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 290317004370 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 290317004371 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290317004372 substrate binding site; other site 290317004373 dimer interface; other site 290317004374 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290317004375 CoenzymeA binding site [chemical binding]; other site 290317004376 subunit interaction site [polypeptide binding]; other site 290317004377 PHB binding site; other site 290317004378 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290317004379 B12 binding site [chemical binding]; other site 290317004380 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290317004381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317004382 FeS/SAM binding site; other site 290317004383 Integrase core domain; Region: rve; cl01316 290317004384 Helix-turn-helix domains; Region: HTH; cl00088 290317004385 PemK-like protein; Region: PemK; cl00995 290317004386 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 290317004387 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 290317004388 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290317004389 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290317004390 dimer interface [polypeptide binding]; other site 290317004391 anticodon binding site; other site 290317004392 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 290317004393 homodimer interface [polypeptide binding]; other site 290317004394 motif 1; other site 290317004395 active site 290317004396 motif 2; other site 290317004397 GAD domain; Region: GAD; pfam02938 290317004398 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 290317004399 active site 290317004400 motif 3; other site 290317004401 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 290317004402 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955 290317004403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317004404 Walker A motif; other site 290317004405 ATP binding site [chemical binding]; other site 290317004406 Walker B motif; other site 290317004407 arginine finger; other site 290317004408 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 290317004409 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 290317004410 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 290317004411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317004412 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290317004413 putative active site [active] 290317004414 catalytic triad [active] 290317004415 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 290317004416 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290317004417 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290317004418 oligomerization interface [polypeptide binding]; other site 290317004419 active site 290317004420 metal binding site [ion binding]; metal-binding site 290317004421 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 290317004422 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 290317004423 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290317004424 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290317004425 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317004426 TPR repeat; Region: TPR_11; pfam13414 290317004427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317004428 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317004429 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290317004430 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290317004431 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004432 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004433 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290317004434 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317004435 Walker A/P-loop; other site 290317004436 ATP binding site [chemical binding]; other site 290317004437 Q-loop/lid; other site 290317004438 ABC transporter signature motif; other site 290317004439 Walker B; other site 290317004440 D-loop; other site 290317004441 H-loop/switch region; other site 290317004442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317004443 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290317004444 FtsX-like permease family; Region: FtsX; cl15850 290317004445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290317004446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290317004447 FtsX-like permease family; Region: FtsX; cl15850 290317004448 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290317004449 ligand binding site [chemical binding]; other site 290317004450 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 290317004451 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 290317004452 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 290317004453 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 290317004454 trimer interface [polypeptide binding]; other site 290317004455 active site 290317004456 UDP-GlcNAc binding site [chemical binding]; other site 290317004457 lipid binding site [chemical binding]; lipid-binding site 290317004458 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 290317004459 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290317004460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290317004461 active site 290317004462 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 290317004463 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290317004464 5S rRNA interface [nucleotide binding]; other site 290317004465 CTC domain interface [polypeptide binding]; other site 290317004466 L16 interface [polypeptide binding]; other site 290317004467 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290317004468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290317004469 dimer interface [polypeptide binding]; other site 290317004470 conserved gate region; other site 290317004471 putative PBP binding loops; other site 290317004472 ABC-ATPase subunit interface; other site 290317004473 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290317004474 dimer interface [polypeptide binding]; other site 290317004475 ADP-ribose binding site [chemical binding]; other site 290317004476 active site 290317004477 nudix motif; other site 290317004478 metal binding site [ion binding]; metal-binding site 290317004479 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290317004480 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290317004481 NAD(P) binding site [chemical binding]; other site 290317004482 putative active site [active] 290317004483 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 290317004484 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 290317004485 metal binding site [ion binding]; metal-binding site 290317004486 dimer interface [polypeptide binding]; other site 290317004487 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 290317004488 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 290317004489 putative ligand binding site [chemical binding]; other site 290317004490 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290317004491 TM-ABC transporter signature motif; other site 290317004492 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290317004493 TM-ABC transporter signature motif; other site 290317004494 Mg chelatase-related protein; Region: TIGR00368 290317004495 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 290317004496 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 290317004497 Walker A/P-loop; other site 290317004498 ATP binding site [chemical binding]; other site 290317004499 Q-loop/lid; other site 290317004500 ABC transporter signature motif; other site 290317004501 Walker B; other site 290317004502 D-loop; other site 290317004503 H-loop/switch region; other site 290317004504 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 290317004505 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 290317004506 Walker A/P-loop; other site 290317004507 ATP binding site [chemical binding]; other site 290317004508 Q-loop/lid; other site 290317004509 ABC transporter signature motif; other site 290317004510 Walker B; other site 290317004511 D-loop; other site 290317004512 H-loop/switch region; other site 290317004513 Protein of unknown function (DUF419); Region: DUF419; cl15265 290317004514 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 290317004515 inhibitor binding site; inhibition site 290317004516 catalytic motif [active] 290317004517 Catalytic residue [active] 290317004518 Active site flap [active] 290317004519 UbiA prenyltransferase family; Region: UbiA; cl00337 290317004520 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 290317004521 Phd_YefM; Region: PhdYeFM; cl09153 290317004522 putative transposase OrfB; Reviewed; Region: PHA02517 290317004523 Helix-turn-helix domains; Region: HTH; cl00088 290317004524 Integrase core domain; Region: rve; cl01316 290317004525 Integrase core domain; Region: rve_3; cl15866 290317004526 Helix-turn-helix domains; Region: HTH; cl00088 290317004527 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 290317004528 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 290317004529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317004530 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004531 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 290317004532 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 290317004533 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 290317004534 putative active site [active] 290317004535 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 290317004536 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 290317004537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317004538 ATP binding site [chemical binding]; other site 290317004539 putative Mg++ binding site [ion binding]; other site 290317004540 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 290317004541 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317004542 Divergent AAA domain; Region: AAA_4; pfam04326 290317004543 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290317004544 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 290317004545 active site 290317004546 catalytic triad [active] 290317004547 dimer interface [polypeptide binding]; other site 290317004548 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 290317004549 putative active site [active] 290317004550 putative NTP binding site [chemical binding]; other site 290317004551 putative nucleic acid binding site [nucleotide binding]; other site 290317004552 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 290317004553 CHC2 zinc finger; Region: zf-CHC2; cl15369 290317004554 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290317004555 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 290317004556 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317004557 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290317004558 BRO family, N-terminal domain; Region: Bro-N; cl10591 290317004559 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 290317004560 HsdM N-terminal domain; Region: HsdM_N; pfam12161 290317004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 290317004562 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290317004563 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 290317004564 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 290317004565 ADP-ribose binding site [chemical binding]; other site 290317004566 TolB amino-terminal domain; Region: TolB_N; cl00639 290317004567 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290317004568 catalytic residues [active] 290317004569 OsmC-like protein; Region: OsmC; cl00767 290317004570 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 290317004571 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 290317004572 Competence protein; Region: Competence; cl00471 290317004573 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 290317004574 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 290317004575 FAD binding site [chemical binding]; other site 290317004576 diaminopimelate decarboxylase; Region: lysA; TIGR01048 290317004577 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290317004578 active site 290317004579 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290317004580 substrate binding site [chemical binding]; other site 290317004581 catalytic residues [active] 290317004582 dimer interface [polypeptide binding]; other site 290317004583 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 290317004584 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 290317004585 Putative zinc ribbon domain; Region: DUF164; pfam02591 290317004586 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 290317004587 hypothetical protein; Provisional; Region: PRK08912 290317004588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290317004589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317004590 homodimer interface [polypeptide binding]; other site 290317004591 catalytic residue [active] 290317004592 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 290317004593 Protein of unknown function (DUF456); Region: DUF456; cl01069 290317004594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290317004595 catalytic loop [active] 290317004596 iron binding site [ion binding]; other site 290317004597 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 290317004598 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 290317004599 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 290317004600 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 290317004601 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290317004602 HflX GTPase family; Region: HflX; cd01878 290317004603 G1 box; other site 290317004604 GTP/Mg2+ binding site [chemical binding]; other site 290317004605 Switch I region; other site 290317004606 G2 box; other site 290317004607 G3 box; other site 290317004608 Switch II region; other site 290317004609 G4 box; other site 290317004610 G5 box; other site 290317004611 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 290317004612 active site lid residues [active] 290317004613 substrate binding pocket [chemical binding]; other site 290317004614 catalytic residues [active] 290317004615 substrate-Mg2+ binding site; other site 290317004616 aspartate-rich region 1; other site 290317004617 aspartate-rich region 2; other site 290317004618 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 290317004619 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290317004620 dimer interface [polypeptide binding]; other site 290317004621 putative anticodon binding site; other site 290317004622 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 290317004623 motif 1; other site 290317004624 active site 290317004625 motif 2; other site 290317004626 motif 3; other site 290317004627 Divergent AAA domain; Region: AAA_4; pfam04326 290317004628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290317004629 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 290317004630 putative NAD(P) binding site [chemical binding]; other site 290317004631 active site 290317004632 putative substrate binding site [chemical binding]; other site 290317004633 Uncharacterized conserved protein [Function unknown]; Region: COG2308 290317004634 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 290317004635 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 290317004636 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 290317004637 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 290317004638 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 290317004639 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290317004640 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 290317004641 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004642 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317004643 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 290317004644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004645 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 290317004646 GTP/Mg2+ binding site [chemical binding]; other site 290317004647 G5 box; other site 290317004648 G1 box; other site 290317004649 Walker A/P-loop; other site 290317004650 ATP binding site [chemical binding]; other site 290317004651 Q-loop/lid; other site 290317004652 ABC transporter signature motif; other site 290317004653 Walker B; other site 290317004654 D-loop; other site 290317004655 H-loop/switch region; other site 290317004656 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 290317004657 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317004658 This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export...; Region: ABCC_Protease_Secretion; cd03246 290317004659 Walker A/P-loop; other site 290317004660 ATP binding site [chemical binding]; other site 290317004661 Q-loop/lid; other site 290317004662 ABC transporter signature motif; other site 290317004663 Walker B; other site 290317004664 D-loop; other site 290317004665 H-loop/switch region; other site 290317004666 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290317004667 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290317004668 active site 290317004669 metal binding site [ion binding]; metal-binding site 290317004670 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 290317004671 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 290317004672 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290317004673 active site 290317004674 metal binding site [ion binding]; metal-binding site 290317004675 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290317004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 290317004677 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290317004678 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl12039 290317004679 dimer interface [polypeptide binding]; other site 290317004680 active site 290317004681 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290317004682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317004683 Integrase core domain; Region: rve; cl01316 290317004684 transposase; Provisional; Region: PRK06526 290317004685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317004686 Walker A motif; other site 290317004687 ATP binding site [chemical binding]; other site 290317004688 Walker B motif; other site 290317004689 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 290317004690 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317004691 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317004692 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290317004693 Domain of unknown function (DUF4402); Region: DUF4402; pfam14352 290317004694 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 290317004695 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 290317004696 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290317004697 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 290317004698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317004699 FeS/SAM binding site; other site 290317004700 hypothetical protein; Reviewed; Region: PRK00024 290317004701 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 290317004702 MPN+ (JAMM) motif; other site 290317004703 Zinc-binding site [ion binding]; other site 290317004704 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 290317004705 DNA-binding site [nucleotide binding]; DNA binding site 290317004706 RNA-binding motif; other site 290317004707 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290317004708 classical (c) SDRs; Region: SDR_c; cd05233 290317004709 NAD(P) binding site [chemical binding]; other site 290317004710 active site 290317004711 GatB domain; Region: GatB_Yqey; cl11497 290317004712 seryl-tRNA synthetase; Provisional; Region: PRK05431 290317004713 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290317004714 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 290317004715 dimer interface [polypeptide binding]; other site 290317004716 active site 290317004717 motif 1; other site 290317004718 motif 2; other site 290317004719 motif 3; other site 290317004720 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317004721 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 290317004722 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 290317004723 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290317004724 homodimer interface [polypeptide binding]; other site 290317004725 substrate-cofactor binding pocket; other site 290317004726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317004727 catalytic residue [active] 290317004728 16S rRNA methyltransferase B; Provisional; Region: PRK14904 290317004729 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 290317004730 putative RNA binding site [nucleotide binding]; other site 290317004731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317004732 S-adenosylmethionine binding site [chemical binding]; other site 290317004733 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290317004734 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290317004735 Int/Topo IB signature motif; other site 290317004736 active site 290317004737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317004738 TPR motif; other site 290317004739 binding surface 290317004740 TPR repeat; Region: TPR_11; pfam13414 290317004741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290317004742 binding surface 290317004743 TPR motif; other site 290317004744 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 290317004745 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 290317004746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290317004747 Beta-Casp domain; Region: Beta-Casp; cl12567 290317004748 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 290317004749 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290317004750 putative metal binding site [ion binding]; other site 290317004751 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290317004752 putative catalytic site [active] 290317004753 putative phosphate binding site [ion binding]; other site 290317004754 putative metal binding site [ion binding]; other site 290317004755 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290317004756 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290317004757 ATP binding site [chemical binding]; other site 290317004758 Mg++ binding site [ion binding]; other site 290317004759 motif III; other site 290317004760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317004761 nucleotide binding region [chemical binding]; other site 290317004762 ATP-binding site [chemical binding]; other site 290317004763 DbpA RNA binding domain; Region: DbpA; pfam03880 290317004764 Integral membrane protein TerC family; Region: TerC; cl10468 290317004765 Amino acid permease; Region: AA_permease; cl00524 290317004766 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 290317004767 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 290317004768 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317004769 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 290317004770 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 290317004771 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 290317004772 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 290317004773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004774 Walker A/P-loop; other site 290317004775 ATP binding site [chemical binding]; other site 290317004776 Q-loop/lid; other site 290317004777 ABC transporter signature motif; other site 290317004778 Walker B; other site 290317004779 D-loop; other site 290317004780 H-loop/switch region; other site 290317004781 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 290317004782 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 290317004783 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290317004784 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 290317004785 active site 290317004786 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290317004787 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290317004788 TSCPD domain; Region: TSCPD; cl14834 290317004789 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 290317004790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004791 NAD(P) binding site [chemical binding]; other site 290317004792 active site 290317004793 Helix-turn-helix domains; Region: HTH; cl00088 290317004794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317004795 putative active site [active] 290317004796 heme pocket [chemical binding]; other site 290317004797 Response regulator receiver domain; Region: Response_reg; pfam00072 290317004798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004799 active site 290317004800 phosphorylation site [posttranslational modification] 290317004801 intermolecular recognition site; other site 290317004802 dimerization interface [polypeptide binding]; other site 290317004803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317004804 PAS fold; Region: PAS_3; pfam08447 290317004805 putative active site [active] 290317004806 heme pocket [chemical binding]; other site 290317004807 PAS domain S-box; Region: sensory_box; TIGR00229 290317004808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317004809 putative active site [active] 290317004810 heme pocket [chemical binding]; other site 290317004811 PAS domain S-box; Region: sensory_box; TIGR00229 290317004812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317004813 putative active site [active] 290317004814 heme pocket [chemical binding]; other site 290317004815 PAS fold; Region: PAS_3; pfam08447 290317004816 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 290317004817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317004818 dimer interface [polypeptide binding]; other site 290317004819 phosphorylation site [posttranslational modification] 290317004820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317004821 ATP binding site [chemical binding]; other site 290317004822 Mg2+ binding site [ion binding]; other site 290317004823 G-X-G motif; other site 290317004824 Response regulator receiver domain; Region: Response_reg; pfam00072 290317004825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004826 active site 290317004827 phosphorylation site [posttranslational modification] 290317004828 intermolecular recognition site; other site 290317004829 dimerization interface [polypeptide binding]; other site 290317004830 CheB methylesterase; Region: CheB_methylest; pfam01339 290317004831 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 290317004832 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 290317004833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004834 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 290317004835 PAS domain; Region: PAS_10; pfam13596 290317004836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317004837 PAS domain; Region: PAS_9; pfam13426 290317004838 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290317004839 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 290317004840 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 290317004841 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 290317004842 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290317004843 putative NAD(P) binding site [chemical binding]; other site 290317004844 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 290317004845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290317004847 DNA binding residues [nucleotide binding] 290317004848 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290317004849 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 290317004850 G1 box; other site 290317004851 putative GEF interaction site [polypeptide binding]; other site 290317004852 GTP/Mg2+ binding site [chemical binding]; other site 290317004853 Switch I region; other site 290317004854 G2 box; other site 290317004855 G3 box; other site 290317004856 Switch II region; other site 290317004857 G4 box; other site 290317004858 G5 box; other site 290317004859 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 290317004860 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290317004861 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 290317004862 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290317004863 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 290317004864 tRNA; other site 290317004865 putative tRNA binding site [nucleotide binding]; other site 290317004866 putative NADP binding site [chemical binding]; other site 290317004867 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290317004868 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290317004869 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 290317004870 domain interfaces; other site 290317004871 active site 290317004872 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290317004873 active site 290317004874 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 290317004875 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 290317004876 active site 290317004877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317004878 dimer interface [polypeptide binding]; other site 290317004879 phosphorylation site [posttranslational modification] 290317004880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317004881 ATP binding site [chemical binding]; other site 290317004882 Mg2+ binding site [ion binding]; other site 290317004883 G-X-G motif; other site 290317004884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004885 active site 290317004886 phosphorylation site [posttranslational modification] 290317004887 intermolecular recognition site; other site 290317004888 dimerization interface [polypeptide binding]; other site 290317004889 Response regulator receiver domain; Region: Response_reg; pfam00072 290317004890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004891 active site 290317004892 phosphorylation site [posttranslational modification] 290317004893 intermolecular recognition site; other site 290317004894 dimerization interface [polypeptide binding]; other site 290317004895 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290317004896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317004897 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 290317004898 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290317004899 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 290317004900 dimer interface [polypeptide binding]; other site 290317004901 allosteric magnesium binding site [ion binding]; other site 290317004902 active site 290317004903 aspartate-rich active site metal binding site; other site 290317004904 Schiff base residues; other site 290317004905 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290317004906 Tetramer interface [polypeptide binding]; other site 290317004907 active site 290317004908 FMN-binding site [chemical binding]; other site 290317004909 serine acetyltransferase; Provisional; Region: cysE; PRK11132 290317004910 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 290317004911 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290317004912 trimer interface [polypeptide binding]; other site 290317004913 active site 290317004914 substrate binding site [chemical binding]; other site 290317004915 CoA binding site [chemical binding]; other site 290317004916 ResB-like family; Region: ResB; pfam05140 290317004917 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 290317004918 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290317004919 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290317004920 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 290317004921 DXD motif; other site 290317004922 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290317004923 putative ADP-binding pocket [chemical binding]; other site 290317004924 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290317004925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317004926 active site 290317004927 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317004928 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290317004929 FeS/SAM binding site; other site 290317004930 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 290317004931 O-Antigen ligase; Region: Wzy_C; cl04850 290317004932 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290317004933 trimer interface [polypeptide binding]; other site 290317004934 active site 290317004935 substrate binding site [chemical binding]; other site 290317004936 CoA binding site [chemical binding]; other site 290317004937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317004938 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290317004939 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 290317004940 AAA domain; Region: AAA_31; pfam13614 290317004941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317004942 MatE; Region: MatE; cl10513 290317004943 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 290317004944 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 290317004945 Ligand binding site; other site 290317004946 metal-binding site 290317004947 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317004948 polysaccharide export protein Wza; Provisional; Region: PRK15078 290317004949 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 290317004950 SLBB domain; Region: SLBB; pfam10531 290317004951 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 290317004952 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290317004953 trimer interface [polypeptide binding]; other site 290317004954 active site 290317004955 substrate binding site [chemical binding]; other site 290317004956 CoA binding site [chemical binding]; other site 290317004957 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290317004958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317004959 active site 290317004960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317004961 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290317004962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317004963 ATP binding site [chemical binding]; other site 290317004964 Mg2+ binding site [ion binding]; other site 290317004965 G-X-G motif; other site 290317004966 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290317004967 anti sigma factor interaction site; other site 290317004968 regulatory phosphorylation site [posttranslational modification]; other site 290317004969 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317004970 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 290317004971 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290317004972 anti sigma factor interaction site; other site 290317004973 regulatory phosphorylation site [posttranslational modification]; other site 290317004974 Bacterial sugar transferase; Region: Bac_transf; cl00939 290317004975 Bacterial sugar transferase; Region: Bac_transf; cl00939 290317004976 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290317004977 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290317004978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317004979 Walker A motif; other site 290317004980 ATP binding site [chemical binding]; other site 290317004981 Walker B motif; other site 290317004982 arginine finger; other site 290317004983 Helix-turn-helix domains; Region: HTH; cl00088 290317004984 Response regulator receiver domain; Region: Response_reg; pfam00072 290317004985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004986 active site 290317004987 phosphorylation site [posttranslational modification] 290317004988 intermolecular recognition site; other site 290317004989 dimerization interface [polypeptide binding]; other site 290317004990 PAS domain S-box; Region: sensory_box; TIGR00229 290317004991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317004992 putative active site [active] 290317004993 heme pocket [chemical binding]; other site 290317004994 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 290317004995 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 290317004996 Response regulator receiver domain; Region: Response_reg; pfam00072 290317004997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317004998 active site 290317004999 phosphorylation site [posttranslational modification] 290317005000 intermolecular recognition site; other site 290317005001 dimerization interface [polypeptide binding]; other site 290317005002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317005003 PAS domain; Region: PAS_9; pfam13426 290317005004 putative active site [active] 290317005005 heme pocket [chemical binding]; other site 290317005006 PAS domain S-box; Region: sensory_box; TIGR00229 290317005007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317005008 putative active site [active] 290317005009 heme pocket [chemical binding]; other site 290317005010 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 290317005011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317005012 dimer interface [polypeptide binding]; other site 290317005013 phosphorylation site [posttranslational modification] 290317005014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317005015 ATP binding site [chemical binding]; other site 290317005016 G-X-G motif; other site 290317005017 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290317005018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317005019 S-adenosylmethionine binding site [chemical binding]; other site 290317005020 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 290317005021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290317005022 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 290317005023 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 290317005024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317005025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005026 binding surface 290317005027 TPR motif; other site 290317005028 TPR repeat; Region: TPR_11; pfam13414 290317005029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005030 TPR repeat; Region: TPR_11; pfam13414 290317005031 binding surface 290317005032 TPR motif; other site 290317005033 TPR repeat; Region: TPR_11; pfam13414 290317005034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005035 binding surface 290317005036 TPR motif; other site 290317005037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005038 binding surface 290317005039 TPR motif; other site 290317005040 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005042 binding surface 290317005043 TPR repeat; Region: TPR_11; pfam13414 290317005044 TPR motif; other site 290317005045 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005047 binding surface 290317005048 TPR motif; other site 290317005049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005050 binding surface 290317005051 TPR motif; other site 290317005052 TPR repeat; Region: TPR_11; pfam13414 290317005053 TPR repeat; Region: TPR_11; pfam13414 290317005054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005055 binding surface 290317005056 TPR motif; other site 290317005057 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005059 binding surface 290317005060 TPR motif; other site 290317005061 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317005062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005063 binding surface 290317005064 TPR motif; other site 290317005065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005066 binding surface 290317005067 TPR repeat; Region: TPR_11; pfam13414 290317005068 TPR motif; other site 290317005069 TPR repeat; Region: TPR_11; pfam13414 290317005070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005071 binding surface 290317005072 TPR motif; other site 290317005073 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317005075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005076 binding surface 290317005077 TPR motif; other site 290317005078 TPR repeat; Region: TPR_11; pfam13414 290317005079 TPR repeat; Region: TPR_11; pfam13414 290317005080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005081 binding surface 290317005082 TPR motif; other site 290317005083 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005085 binding surface 290317005086 TPR motif; other site 290317005087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317005088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005089 binding surface 290317005090 TPR motif; other site 290317005091 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 290317005092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005093 binding surface 290317005094 TPR motif; other site 290317005095 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005097 binding surface 290317005098 TPR motif; other site 290317005099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005100 binding surface 290317005101 TPR motif; other site 290317005102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005103 binding surface 290317005104 TPR motif; other site 290317005105 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 290317005106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290317005107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005108 binding surface 290317005109 TPR motif; other site 290317005110 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005112 binding surface 290317005113 TPR motif; other site 290317005114 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317005115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005116 binding surface 290317005117 TPR motif; other site 290317005118 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005120 binding surface 290317005121 TPR motif; other site 290317005122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005123 binding surface 290317005124 TPR motif; other site 290317005125 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 290317005126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005127 binding surface 290317005128 TPR motif; other site 290317005129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005130 binding surface 290317005131 TPR motif; other site 290317005132 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 290317005133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005134 binding surface 290317005135 TPR motif; other site 290317005136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317005137 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 290317005138 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317005139 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 290317005140 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290317005141 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290317005142 ligand binding site [chemical binding]; other site 290317005143 flexible hinge region; other site 290317005144 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 290317005145 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 290317005146 putative active site [active] 290317005147 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317005148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317005149 Walker A/P-loop; other site 290317005150 ATP binding site [chemical binding]; other site 290317005151 Q-loop/lid; other site 290317005152 ABC transporter signature motif; other site 290317005153 Walker B; other site 290317005154 D-loop; other site 290317005155 H-loop/switch region; other site 290317005156 PPIC-type PPIASE domain; Region: Rotamase; cl08278 290317005157 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290317005158 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005159 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005160 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005161 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005162 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005163 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005164 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005165 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005166 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005167 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005168 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290317005169 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290317005170 active site 290317005171 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 290317005172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317005173 FeS/SAM binding site; other site 290317005174 PUCC protein; Region: PUCC; pfam03209 290317005175 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290317005176 ThiC-associated domain; Region: ThiC-associated; pfam13667 290317005177 ThiC family; Region: ThiC; cl08031 290317005178 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290317005179 substrate binding site [chemical binding]; other site 290317005180 dimer interface [polypeptide binding]; other site 290317005181 catalytic triad [active] 290317005182 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290317005183 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290317005184 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290317005185 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 290317005186 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290317005187 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290317005188 protein binding site [polypeptide binding]; other site 290317005189 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290317005190 protein binding site [polypeptide binding]; other site 290317005191 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 290317005192 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290317005193 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290317005194 signal peptidase I; Provisional; Region: PRK10861 290317005195 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290317005196 Catalytic site [active] 290317005197 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290317005198 GTP-binding protein LepA; Provisional; Region: PRK05433 290317005199 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290317005200 G1 box; other site 290317005201 putative GEF interaction site [polypeptide binding]; other site 290317005202 GTP/Mg2+ binding site [chemical binding]; other site 290317005203 Switch I region; other site 290317005204 G2 box; other site 290317005205 G3 box; other site 290317005206 Switch II region; other site 290317005207 G4 box; other site 290317005208 G5 box; other site 290317005209 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 290317005210 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290317005211 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290317005212 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290317005213 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290317005214 putative active site [active] 290317005215 substrate binding site [chemical binding]; other site 290317005216 putative cosubstrate binding site; other site 290317005217 catalytic site [active] 290317005218 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290317005219 substrate binding site [chemical binding]; other site 290317005220 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290317005221 active site 290317005222 catalytic residues [active] 290317005223 metal binding site [ion binding]; metal-binding site 290317005224 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290317005225 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290317005226 Ligand Binding Site [chemical binding]; other site 290317005227 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290317005228 gamma-glutamyl kinase; Provisional; Region: PRK05429 290317005229 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290317005230 nucleotide binding site [chemical binding]; other site 290317005231 homotetrameric interface [polypeptide binding]; other site 290317005232 putative phosphate binding site [ion binding]; other site 290317005233 putative allosteric binding site; other site 290317005234 PUA domain; Region: PUA; cl00607 290317005235 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290317005236 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290317005237 putative catalytic cysteine [active] 290317005238 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 290317005239 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 290317005240 Walker A/P-loop; other site 290317005241 ATP binding site [chemical binding]; other site 290317005242 Q-loop/lid; other site 290317005243 ABC transporter signature motif; other site 290317005244 Walker B; other site 290317005245 D-loop; other site 290317005246 H-loop/switch region; other site 290317005247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290317005248 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290317005249 putative substrate translocation pore; other site 290317005250 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290317005251 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290317005252 inhibitor-cofactor binding pocket; inhibition site 290317005253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317005254 catalytic residue [active] 290317005255 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 290317005256 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290317005257 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290317005258 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290317005259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317005260 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 290317005261 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290317005262 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317005263 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290317005264 chaperone protein DnaJ; Provisional; Region: PRK14281 290317005265 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290317005266 HSP70 interaction site [polypeptide binding]; other site 290317005267 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 290317005268 substrate binding site [polypeptide binding]; other site 290317005269 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290317005270 Zn binding sites [ion binding]; other site 290317005271 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290317005272 dimer interface [polypeptide binding]; other site 290317005273 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 290317005274 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290317005275 dimer interface [polypeptide binding]; other site 290317005276 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290317005277 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 290317005278 HrcA protein C terminal domain; Region: HrcA; pfam01628 290317005279 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290317005280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317005281 S-adenosylmethionine binding site [chemical binding]; other site 290317005282 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 290317005283 prolyl-tRNA synthetase; Provisional; Region: PRK08661 290317005284 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 290317005285 dimer interface [polypeptide binding]; other site 290317005286 motif 1; other site 290317005287 active site 290317005288 motif 2; other site 290317005289 motif 3; other site 290317005290 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 290317005291 anticodon binding site; other site 290317005292 zinc-binding site [ion binding]; other site 290317005293 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290317005294 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 290317005295 dimer interface [polypeptide binding]; other site 290317005296 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290317005297 catalytic triad [active] 290317005298 peroxidatic and resolving cysteines [active] 290317005299 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290317005300 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290317005301 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 290317005302 putative active site [active] 290317005303 catalytic triad [active] 290317005304 putative dimer interface [polypeptide binding]; other site 290317005305 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616 290317005306 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290317005307 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 290317005308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317005309 Walker A motif; other site 290317005310 ATP binding site [chemical binding]; other site 290317005311 Walker B motif; other site 290317005312 arginine finger; other site 290317005313 Helix-turn-helix domains; Region: HTH; cl00088 290317005314 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 290317005315 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 290317005316 putative active site [active] 290317005317 catalytic triad [active] 290317005318 putative dimer interface [polypeptide binding]; other site 290317005319 Bacteriochlorophyll A protein; Region: BChl_A; pfam02327 290317005320 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290317005321 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290317005322 DNA binding residues [nucleotide binding] 290317005323 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290317005324 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317005325 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317005326 Walker A/P-loop; other site 290317005327 ATP binding site [chemical binding]; other site 290317005328 Q-loop/lid; other site 290317005329 ABC transporter signature motif; other site 290317005330 Walker B; other site 290317005331 D-loop; other site 290317005332 H-loop/switch region; other site 290317005333 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 290317005334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317005335 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317005336 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 290317005337 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317005338 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 290317005339 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290317005340 putative active site [active] 290317005341 putative metal binding site [ion binding]; other site 290317005342 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290317005343 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 290317005344 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 290317005345 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317005346 Uncharacterized conserved protein [Function unknown]; Region: COG1262 290317005347 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317005348 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290317005349 B12 binding site [chemical binding]; other site 290317005350 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290317005351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317005352 FeS/SAM binding site; other site 290317005353 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 290317005354 MutS domain I; Region: MutS_I; pfam01624 290317005355 MutS domain II; Region: MutS_II; pfam05188 290317005356 MutS family domain IV; Region: MutS_IV; pfam05190 290317005357 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 290317005358 Walker A/P-loop; other site 290317005359 ATP binding site [chemical binding]; other site 290317005360 Q-loop/lid; other site 290317005361 ABC transporter signature motif; other site 290317005362 Walker B; other site 290317005363 D-loop; other site 290317005364 H-loop/switch region; other site 290317005365 Copper resistance protein D; Region: CopD; cl00563 290317005366 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 290317005367 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 290317005368 malate dehydrogenase; Reviewed; Region: PRK06223 290317005369 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 290317005370 NAD(P) binding site [chemical binding]; other site 290317005371 dimer interface [polypeptide binding]; other site 290317005372 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290317005373 substrate binding site [chemical binding]; other site 290317005374 agmatine deiminase; Region: agmatine_aguA; TIGR03380 290317005375 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 290317005376 Peptidase family M48; Region: Peptidase_M48; cl12018 290317005377 N-carbamolyputrescine amidase; Region: PLN02747 290317005378 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 290317005379 putative active site; other site 290317005380 catalytic triad [active] 290317005381 putative dimer interface [polypeptide binding]; other site 290317005382 UbiA prenyltransferase family; Region: UbiA; cl00337 290317005383 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290317005384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290317005385 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 290317005386 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290317005387 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290317005388 substrate binding site [chemical binding]; other site 290317005389 glutamase interaction surface [polypeptide binding]; other site 290317005390 Restriction endonuclease XhoI; Region: XhoI; pfam04555 290317005391 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290317005392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 290317005393 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 290317005394 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 290317005395 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290317005396 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 290317005397 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290317005398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 290317005399 FeS/SAM binding site; other site 290317005400 Restriction endonuclease NotI; Region: NotI; pfam12183 290317005401 Restriction endonuclease NotI; Region: NotI; pfam12183 290317005402 O-methyltransferase; Region: Methyltransf_3; pfam01596 290317005403 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290317005404 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 290317005405 active site 290317005406 purine riboside binding site [chemical binding]; other site 290317005407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290317005408 active site 290317005409 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 290317005410 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 290317005411 active site 290317005412 catalytic residues [active] 290317005413 metal binding site [ion binding]; metal-binding site 290317005414 Nif-specific regulatory protein; Region: nifA; TIGR01817 290317005415 GAF domain; Region: GAF; cl00853 290317005416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317005417 Walker A motif; other site 290317005418 ATP binding site [chemical binding]; other site 290317005419 Walker B motif; other site 290317005420 arginine finger; other site 290317005421 Helix-turn-helix domains; Region: HTH; cl00088 290317005422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290317005423 active site 290317005424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290317005425 catalytic tetrad [active] 290317005426 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290317005427 amphipathic channel; other site 290317005428 Asn-Pro-Ala signature motifs; other site 290317005429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317005430 Integrase core domain; Region: rve; cl01316 290317005431 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290317005432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317005433 Walker A motif; other site 290317005434 ATP binding site [chemical binding]; other site 290317005435 Walker B motif; other site 290317005436 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 290317005437 NlpE N-terminal domain; Region: NlpE; cl01138 290317005438 META domain; Region: META; cl01245 290317005439 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290317005440 active site 290317005441 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 290317005442 putative hydrophobic ligand binding site [chemical binding]; other site 290317005443 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 290317005444 flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958 290317005445 NADP binding site [chemical binding]; other site 290317005446 substrate binding site [chemical binding]; other site 290317005447 active site 290317005448 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290317005449 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290317005450 Probable Catalytic site; other site 290317005451 metal-binding site 290317005452 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 290317005453 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290317005454 substrate binding site [chemical binding]; other site 290317005455 active site 290317005456 catalytic residues [active] 290317005457 heterodimer interface [polypeptide binding]; other site 290317005458 CAAX protease self-immunity; Region: Abi; cl00558 290317005459 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 290317005460 Ligand Binding Site [chemical binding]; other site 290317005461 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290317005462 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290317005463 ring oligomerisation interface [polypeptide binding]; other site 290317005464 ATP/Mg binding site [chemical binding]; other site 290317005465 stacking interactions; other site 290317005466 hinge regions; other site 290317005467 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290317005468 oligomerisation interface [polypeptide binding]; other site 290317005469 mobile loop; other site 290317005470 roof hairpin; other site 290317005471 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290317005472 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290317005473 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 290317005474 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 290317005475 Helix-turn-helix domains; Region: HTH; cl00088 290317005476 Rrf2 family protein; Region: rrf2_super; TIGR00738 290317005477 hydrolase; Region: PLN02578 290317005478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317005479 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 290317005480 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290317005481 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 290317005482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317005483 catalytic residue [active] 290317005484 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 290317005485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317005486 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317005487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290317005488 non-specific DNA binding site [nucleotide binding]; other site 290317005489 salt bridge; other site 290317005490 sequence-specific DNA binding site [nucleotide binding]; other site 290317005491 Domain of unknown function (DUF955); Region: DUF955; cl01076 290317005492 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290317005493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317005494 ATP binding site [chemical binding]; other site 290317005495 putative Mg++ binding site [ion binding]; other site 290317005496 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290317005497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317005498 nucleotide binding region [chemical binding]; other site 290317005499 ATP-binding site [chemical binding]; other site 290317005500 putative transposase OrfB; Reviewed; Region: PHA02517 290317005501 HTH-like domain; Region: HTH_21; pfam13276 290317005502 Integrase core domain; Region: rve; cl01316 290317005503 Integrase core domain; Region: rve_3; cl15866 290317005504 Helix-turn-helix domains; Region: HTH; cl00088 290317005505 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 290317005506 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290317005507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290317005508 catalytic residue [active] 290317005509 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290317005510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317005511 ATP binding site [chemical binding]; other site 290317005512 Mg2+ binding site [ion binding]; other site 290317005513 G-X-G motif; other site 290317005514 Response regulator receiver domain; Region: Response_reg; pfam00072 290317005515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317005516 active site 290317005517 phosphorylation site [posttranslational modification] 290317005518 intermolecular recognition site; other site 290317005519 dimerization interface [polypeptide binding]; other site 290317005520 Response regulator receiver domain; Region: Response_reg; pfam00072 290317005521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317005522 active site 290317005523 phosphorylation site [posttranslational modification] 290317005524 intermolecular recognition site; other site 290317005525 dimerization interface [polypeptide binding]; other site 290317005526 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290317005527 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 290317005528 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290317005529 catalytic triad [active] 290317005530 photolyase PhrII; Region: phr2; TIGR00591 290317005531 DNA photolyase; Region: DNA_photolyase; pfam00875 290317005532 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 290317005533 ribonuclease R; Region: RNase_R; TIGR02063 290317005534 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290317005535 RNB domain; Region: RNB; pfam00773 290317005536 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 290317005537 RNA binding site [nucleotide binding]; other site 290317005538 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290317005539 metal binding site 2 [ion binding]; metal-binding site 290317005540 putative DNA binding helix; other site 290317005541 metal binding site 1 [ion binding]; metal-binding site 290317005542 dimer interface [polypeptide binding]; other site 290317005543 structural Zn2+ binding site [ion binding]; other site 290317005544 peroxiredoxin; Provisional; Region: PRK13189 290317005545 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 290317005546 dimer interface [polypeptide binding]; other site 290317005547 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290317005548 catalytic triad [active] 290317005549 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 290317005550 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290317005551 dimer interface [polypeptide binding]; other site 290317005552 PYR/PP interface [polypeptide binding]; other site 290317005553 TPP binding site [chemical binding]; other site 290317005554 substrate binding site [chemical binding]; other site 290317005555 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 290317005556 TPP-binding site; other site 290317005557 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 290317005558 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 290317005559 AMP-binding enzyme; Region: AMP-binding; cl15778 290317005560 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 290317005561 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317005562 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317005563 ACT domain-containing protein [General function prediction only]; Region: COG4747 290317005564 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 290317005565 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 290317005566 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290317005567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290317005568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317005569 homodimer interface [polypeptide binding]; other site 290317005570 catalytic residue [active] 290317005571 N-acetyltransferase; Region: Acetyltransf_2; cl00949 290317005572 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 290317005573 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 290317005574 active site 290317005575 FMN binding site [chemical binding]; other site 290317005576 substrate binding site [chemical binding]; other site 290317005577 putative catalytic residue [active] 290317005578 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290317005579 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290317005580 active site 290317005581 substrate binding site [chemical binding]; other site 290317005582 cosubstrate binding site; other site 290317005583 catalytic site [active] 290317005584 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 290317005585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317005586 FeS/SAM binding site; other site 290317005587 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290317005588 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290317005589 Ligand binding site; other site 290317005590 Putative Catalytic site; other site 290317005591 DXD motif; other site 290317005592 endonuclease IV; Provisional; Region: PRK01060 290317005593 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 290317005594 AP (apurinic/apyrimidinic) site pocket; other site 290317005595 DNA interaction; other site 290317005596 Metal-binding active site; metal-binding site 290317005597 FtsX-like permease family; Region: FtsX; cl15850 290317005598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317005599 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290317005600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290317005601 Protein of unknown function (DUF1847); Region: DUF1847; cl02037 290317005602 amidophosphoribosyltransferase; Provisional; Region: PRK09123 290317005603 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290317005604 active site 290317005605 tetramer interface [polypeptide binding]; other site 290317005606 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 290317005607 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 290317005608 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290317005609 active site 290317005610 HIGH motif; other site 290317005611 nucleotide binding site [chemical binding]; other site 290317005612 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290317005613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290317005614 active site 290317005615 KMSKS motif; other site 290317005616 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 290317005617 tRNA binding surface [nucleotide binding]; other site 290317005618 anticodon binding site; other site 290317005619 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 290317005620 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290317005621 NAD binding site [chemical binding]; other site 290317005622 homodimer interface [polypeptide binding]; other site 290317005623 active site 290317005624 substrate binding site [chemical binding]; other site 290317005625 HEPN domain; Region: HEPN; cl00824 290317005626 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290317005627 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290317005628 NAD binding site [chemical binding]; other site 290317005629 substrate binding site [chemical binding]; other site 290317005630 homodimer interface [polypeptide binding]; other site 290317005631 active site 290317005632 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290317005633 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 290317005634 NADP binding site [chemical binding]; other site 290317005635 active site 290317005636 putative substrate binding site [chemical binding]; other site 290317005637 Cupin domain; Region: Cupin_2; cl09118 290317005638 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290317005639 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290317005640 substrate binding site; other site 290317005641 tetramer interface; other site 290317005642 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290317005643 classical (c) SDRs; Region: SDR_c; cd05233 290317005644 NAD(P) binding site [chemical binding]; other site 290317005645 active site 290317005646 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 290317005647 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 290317005648 dimer interface [polypeptide binding]; other site 290317005649 catalytic residue [active] 290317005650 metal binding site [ion binding]; metal-binding site 290317005651 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 290317005652 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 290317005653 putative active site; other site 290317005654 catalytic residue [active] 290317005655 short chain dehydrogenase; Validated; Region: PRK08324 290317005656 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 290317005657 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 290317005658 putative NAD(P) binding site [chemical binding]; other site 290317005659 active site 290317005660 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353 290317005661 RecX family; Region: RecX; cl00936 290317005662 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290317005663 putative nucleotide binding site [chemical binding]; other site 290317005664 uridine monophosphate binding site [chemical binding]; other site 290317005665 homohexameric interface [polypeptide binding]; other site 290317005666 elongation factor Ts; Provisional; Region: tsf; PRK09377 290317005667 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 290317005668 Elongation factor TS; Region: EF_TS; pfam00889 290317005669 Elongation factor TS; Region: EF_TS; pfam00889 290317005670 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290317005671 rRNA interaction site [nucleotide binding]; other site 290317005672 S8 interaction site; other site 290317005673 putative laminin-1 binding site; other site 290317005674 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 290317005675 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290317005676 23S rRNA interface [nucleotide binding]; other site 290317005677 L3 interface [polypeptide binding]; other site 290317005678 GTP-binding protein Der; Reviewed; Region: PRK00093 290317005679 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290317005680 G1 box; other site 290317005681 GTP/Mg2+ binding site [chemical binding]; other site 290317005682 Switch I region; other site 290317005683 G2 box; other site 290317005684 Switch II region; other site 290317005685 G3 box; other site 290317005686 G4 box; other site 290317005687 G5 box; other site 290317005688 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290317005689 G1 box; other site 290317005690 GTP/Mg2+ binding site [chemical binding]; other site 290317005691 Switch I region; other site 290317005692 G2 box; other site 290317005693 G3 box; other site 290317005694 Switch II region; other site 290317005695 G4 box; other site 290317005696 G5 box; other site 290317005697 antiporter inner membrane protein; Provisional; Region: PRK11670 290317005698 Domain of unknown function DUF59; Region: DUF59; cl00941 290317005699 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290317005700 Walker A motif; other site 290317005701 NifU-like domain; Region: NifU; cl00484 290317005702 DNA translocase FtsK; Provisional; Region: PRK10263 290317005703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317005704 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 290317005705 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290317005706 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290317005707 Repair protein; Region: Repair_PSII; cl01535 290317005708 Repair protein; Region: Repair_PSII; cl01535 290317005709 LemA family; Region: LemA; cl00742 290317005710 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 290317005711 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290317005712 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290317005713 synthetase active site [active] 290317005714 NTP binding site [chemical binding]; other site 290317005715 metal binding site [ion binding]; metal-binding site 290317005716 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290317005717 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290317005718 excinuclease ABC subunit B; Provisional; Region: PRK05298 290317005719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317005720 ATP binding site [chemical binding]; other site 290317005721 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290317005722 active site 290317005723 ATP binding site [chemical binding]; other site 290317005724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317005725 nucleotide binding region [chemical binding]; other site 290317005726 ATP-binding site [chemical binding]; other site 290317005727 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290317005728 UvrB/uvrC motif; Region: UVR; pfam02151 290317005729 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290317005730 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290317005731 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290317005732 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290317005733 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290317005734 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 290317005735 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 290317005736 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290317005737 Uncharacterized conserved protein [Function unknown]; Region: COG1912 290317005738 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 290317005739 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 290317005740 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290317005741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290317005742 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290317005743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290317005744 DNA binding residues [nucleotide binding] 290317005745 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 290317005746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290317005747 active site 290317005748 HIGH motif; other site 290317005749 nucleotide binding site [chemical binding]; other site 290317005750 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290317005751 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290317005752 active site 290317005753 KMSKS motif; other site 290317005754 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290317005755 tRNA binding surface [nucleotide binding]; other site 290317005756 anticodon binding site; other site 290317005757 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 290317005758 Clp protease; Region: CLP_protease; pfam00574 290317005759 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290317005760 oligomer interface [polypeptide binding]; other site 290317005761 active site residues [active] 290317005762 Thymidylate synthase complementing protein; Region: Thy1; cl03630 290317005763 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 290317005764 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 290317005765 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 290317005766 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 290317005767 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 290317005768 active site 290317005769 nucleophile elbow; other site 290317005770 Surface antigen; Region: Bac_surface_Ag; cl03097 290317005771 Survival protein SurE; Region: SurE; cl00448 290317005772 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 290317005773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 290317005774 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 290317005775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317005776 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 290317005777 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290317005778 glutamine binding [chemical binding]; other site 290317005779 catalytic triad [active] 290317005780 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 290317005781 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 290317005782 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 290317005783 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290317005784 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290317005785 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290317005786 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290317005787 active site 290317005788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317005789 Integrase core domain; Region: rve; cl01316 290317005790 transposase; Provisional; Region: PRK06526 290317005791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317005792 Walker A motif; other site 290317005793 ATP binding site [chemical binding]; other site 290317005794 Walker B motif; other site 290317005795 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290317005796 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 290317005797 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 290317005798 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 290317005799 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 290317005800 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 290317005801 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 290317005802 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 290317005803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 290317005804 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 290317005805 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 290317005806 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 290317005807 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 290317005808 putative active site [active] 290317005809 putative NTP binding site [chemical binding]; other site 290317005810 putative nucleic acid binding site [nucleotide binding]; other site 290317005811 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 290317005812 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 290317005813 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 290317005814 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290317005815 synthetase active site [active] 290317005816 NTP binding site [chemical binding]; other site 290317005817 metal binding site [ion binding]; metal-binding site 290317005818 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 290317005819 putative dimer interface [polypeptide binding]; other site 290317005820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290317005821 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 290317005822 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 290317005823 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 290317005824 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 290317005825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290317005826 DNA binding site [nucleotide binding] 290317005827 Int/Topo IB signature motif; other site 290317005828 active site 290317005829 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290317005830 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 290317005831 NAD(P) binding site [chemical binding]; other site 290317005832 catalytic residues [active] 290317005833 GTPase RsgA; Reviewed; Region: PRK00098 290317005834 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290317005835 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290317005836 GTP/Mg2+ binding site [chemical binding]; other site 290317005837 G4 box; other site 290317005838 G5 box; other site 290317005839 G1 box; other site 290317005840 Switch I region; other site 290317005841 G2 box; other site 290317005842 G3 box; other site 290317005843 Switch II region; other site 290317005844 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290317005845 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290317005846 generic binding surface II; other site 290317005847 ssDNA binding site; other site 290317005848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317005849 ATP binding site [chemical binding]; other site 290317005850 putative Mg++ binding site [ion binding]; other site 290317005851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317005852 nucleotide binding region [chemical binding]; other site 290317005853 ATP-binding site [chemical binding]; other site 290317005854 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 290317005855 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 290317005856 hinge region; other site 290317005857 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 290317005858 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 290317005859 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 290317005860 IHF dimer interface [polypeptide binding]; other site 290317005861 IHF - DNA interface [nucleotide binding]; other site 290317005862 Sporulation related domain; Region: SPOR; cl10051 290317005863 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 290317005864 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290317005865 generic binding surface II; other site 290317005866 generic binding surface I; other site 290317005867 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 290317005868 Ligand binding site; other site 290317005869 oligomer interface; other site 290317005870 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 290317005871 putative active site [active] 290317005872 dimerization interface [polypeptide binding]; other site 290317005873 putative tRNAtyr binding site [nucleotide binding]; other site 290317005874 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 290317005875 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 290317005876 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290317005877 Citrate synthase; Region: Citrate_synt; pfam00285 290317005878 oxalacetate binding site [chemical binding]; other site 290317005879 citrylCoA binding site [chemical binding]; other site 290317005880 coenzyme A binding site [chemical binding]; other site 290317005881 catalytic triad [active] 290317005882 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290317005883 ligand binding site [chemical binding]; other site 290317005884 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 290317005885 putative metal binding site [ion binding]; other site 290317005886 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 290317005887 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290317005888 metal-binding site [ion binding] 290317005889 TPR repeat; Region: TPR_11; pfam13414 290317005890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005891 binding surface 290317005892 TPR motif; other site 290317005893 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290317005894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317005895 binding surface 290317005896 TPR motif; other site 290317005897 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290317005898 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 290317005899 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290317005900 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290317005901 dimer interface [polypeptide binding]; other site 290317005902 tetramer interface [polypeptide binding]; other site 290317005903 PYR/PP interface [polypeptide binding]; other site 290317005904 TPP binding site [chemical binding]; other site 290317005905 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290317005906 TPP-binding site; other site 290317005907 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 290317005908 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317005909 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290317005910 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290317005911 substrate binding site [chemical binding]; other site 290317005912 oxyanion hole (OAH) forming residues; other site 290317005913 trimer interface [polypeptide binding]; other site 290317005914 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290317005915 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 290317005916 active site 290317005917 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 290317005918 AMP-binding enzyme; Region: AMP-binding; cl15778 290317005919 dihydrodipicolinate reductase; Provisional; Region: PRK00048 290317005920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317005921 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290317005922 ParB-like nuclease domain; Region: ParBc; cl02129 290317005923 ParB-like partition proteins; Region: parB_part; TIGR00180 290317005924 Helix-turn-helix domains; Region: HTH; cl00088 290317005925 KorB domain; Region: KorB; pfam08535 290317005926 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290317005927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290317005928 P-loop; other site 290317005929 Magnesium ion binding site [ion binding]; other site 290317005930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290317005931 Magnesium ion binding site [ion binding]; other site 290317005932 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 290317005933 active site 290317005934 DNA binding site [nucleotide binding] 290317005935 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 290317005936 MgtE intracellular N domain; Region: MgtE_N; cl15244 290317005937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290317005938 Divalent cation transporter; Region: MgtE; cl00786 290317005939 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 290317005940 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290317005941 Ligand Binding Site [chemical binding]; other site 290317005942 Predicted esterase [General function prediction only]; Region: COG0400 290317005943 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317005944 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 290317005945 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 290317005946 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 290317005947 substrate binding pocket [chemical binding]; other site 290317005948 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 290317005949 B12 binding site [chemical binding]; other site 290317005950 cobalt ligand [ion binding]; other site 290317005951 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 290317005952 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 290317005953 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 290317005954 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 290317005955 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290317005956 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 290317005957 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290317005958 ligand binding site [chemical binding]; other site 290317005959 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317005960 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290317005961 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290317005962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317005963 S-adenosylmethionine binding site [chemical binding]; other site 290317005964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290317005965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317005966 Integrase core domain; Region: rve; cl01316 290317005967 transposase; Provisional; Region: PRK06526 290317005968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317005969 Walker A motif; other site 290317005970 ATP binding site [chemical binding]; other site 290317005971 Walker B motif; other site 290317005972 putative transposase OrfB; Reviewed; Region: PHA02517 290317005973 HTH-like domain; Region: HTH_21; pfam13276 290317005974 Integrase core domain; Region: rve; cl01316 290317005975 Integrase core domain; Region: rve_3; cl15866 290317005976 Helix-turn-helix domains; Region: HTH; cl00088 290317005977 Protein of unknown function, DUF393; Region: DUF393; cl01136 290317005978 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 290317005979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317005980 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290317005981 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 290317005982 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 290317005983 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 290317005984 DsrE/DsrF-like family; Region: DrsE; cl00672 290317005985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290317005986 dimerization interface [polypeptide binding]; other site 290317005987 putative DNA binding site [nucleotide binding]; other site 290317005988 putative Zn2+ binding site [ion binding]; other site 290317005989 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290317005990 active site residue [active] 290317005991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290317005992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317005993 S-adenosylmethionine binding site [chemical binding]; other site 290317005994 CGGC domain; Region: CGGC; cl02356 290317005995 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 290317005996 putative metal binding site [ion binding]; other site 290317005997 putative homotetramer interface [polypeptide binding]; other site 290317005998 putative homodimer interface [polypeptide binding]; other site 290317005999 putative homodimer-homodimer interface [polypeptide binding]; other site 290317006000 putative allosteric switch controlling residues; other site 290317006001 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317006003 Winged helix-turn helix; Region: HTH_29; pfam13551 290317006004 Helix-turn-helix domains; Region: HTH; cl00088 290317006005 Winged helix-turn helix; Region: HTH_33; pfam13592 290317006006 Integrase core domain; Region: rve; cl01316 290317006007 NB-ARC domain; Region: NB-ARC; pfam00931 290317006008 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290317006009 MT-A70; Region: MT-A70; cl01947 290317006010 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 290317006011 Winged helix-turn helix; Region: HTH_29; pfam13551 290317006012 Helix-turn-helix domains; Region: HTH; cl00088 290317006013 Winged helix-turn helix; Region: HTH_33; pfam13592 290317006014 Integrase core domain; Region: rve; cl01316 290317006015 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 290317006016 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 290317006017 putative hydrophobic ligand binding site [chemical binding]; other site 290317006018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 290317006019 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 290317006020 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 290317006021 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 290317006022 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 290317006023 Protein of unknown function (DUF541); Region: SIMPL; cl01077 290317006024 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 290317006025 Uncharacterized conserved protein [Function unknown]; Region: COG5634 290317006026 transketolase; Reviewed; Region: PRK05899 290317006027 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290317006028 TPP-binding site [chemical binding]; other site 290317006029 dimer interface [polypeptide binding]; other site 290317006030 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290317006031 PYR/PP interface [polypeptide binding]; other site 290317006032 dimer interface [polypeptide binding]; other site 290317006033 TPP binding site [chemical binding]; other site 290317006034 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290317006035 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 290317006036 putative active site [active] 290317006037 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290317006038 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290317006039 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290317006040 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 290317006041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317006043 PAS fold; Region: PAS_4; pfam08448 290317006044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317006045 dimer interface [polypeptide binding]; other site 290317006046 phosphorylation site [posttranslational modification] 290317006047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317006048 ATP binding site [chemical binding]; other site 290317006049 Mg2+ binding site [ion binding]; other site 290317006050 G-X-G motif; other site 290317006051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317006052 active site 290317006053 phosphorylation site [posttranslational modification] 290317006054 intermolecular recognition site; other site 290317006055 dimerization interface [polypeptide binding]; other site 290317006056 Response regulator receiver domain; Region: Response_reg; pfam00072 290317006057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317006058 active site 290317006059 phosphorylation site [posttranslational modification] 290317006060 intermolecular recognition site; other site 290317006061 dimerization interface [polypeptide binding]; other site 290317006062 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290317006063 Uncharacterized conserved protein [Function unknown]; Region: COG3287 290317006064 FIST N domain; Region: FIST; cl10701 290317006065 FIST C domain; Region: FIST_C; pfam10442 290317006066 Protein of unknown function (DUF541); Region: SIMPL; cl01077 290317006067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317006068 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 290317006069 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 290317006070 putative deacylase active site [active] 290317006071 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 290317006072 nucleophile elbow; other site 290317006073 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 290317006074 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 290317006075 NAD(P) binding site [chemical binding]; other site 290317006076 catalytic residues [active] 290317006077 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 290317006078 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 290317006079 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 290317006080 Walker A/P-loop; other site 290317006081 ATP binding site [chemical binding]; other site 290317006082 Q-loop/lid; other site 290317006083 ABC transporter signature motif; other site 290317006084 Walker B; other site 290317006085 D-loop; other site 290317006086 H-loop/switch region; other site 290317006087 Integral membrane protein TerC family; Region: TerC; cl10468 290317006088 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290317006089 Ligand Binding Site [chemical binding]; other site 290317006090 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290317006091 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 290317006092 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290317006093 Peptidase family U32; Region: Peptidase_U32; cl03113 290317006094 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 290317006095 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 290317006096 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 290317006097 FAD binding pocket [chemical binding]; other site 290317006098 FAD binding motif [chemical binding]; other site 290317006099 phosphate binding motif [ion binding]; other site 290317006100 beta-alpha-beta structure motif; other site 290317006101 NAD binding pocket [chemical binding]; other site 290317006102 Iron coordination center [ion binding]; other site 290317006103 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 290317006104 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 290317006105 transposase; Provisional; Region: PRK06526 290317006106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006107 Walker A motif; other site 290317006108 ATP binding site [chemical binding]; other site 290317006109 Walker B motif; other site 290317006110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317006111 Integrase core domain; Region: rve; cl01316 290317006112 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 290317006113 Fic/DOC family; Region: Fic; cl00960 290317006114 Predicted ATPase [General function prediction only]; Region: COG4637 290317006115 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317006116 Walker A/P-loop; other site 290317006117 ATP binding site [chemical binding]; other site 290317006118 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 290317006119 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 290317006120 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 290317006121 Protein of unknown function (DUF3680); Region: DUF3680; cl02189 290317006122 Protein of unknown function (DUF433); Region: DUF433; cl01030 290317006123 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 290317006124 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 290317006125 Virulence protein [General function prediction only]; Region: COG3943 290317006126 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 290317006127 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 290317006128 HicB family; Region: HicB; pfam05534 290317006129 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290317006130 Protein of unknown function (DUF433); Region: DUF433; cl01030 290317006131 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 290317006132 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 290317006133 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317006134 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290317006135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317006136 binding surface 290317006137 TPR motif; other site 290317006138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317006139 binding surface 290317006140 TPR motif; other site 290317006141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317006142 binding surface 290317006143 TPR motif; other site 290317006144 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006145 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006146 AAA domain; Region: AAA_21; pfam13304 290317006147 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 290317006148 RloB-like protein; Region: RloB; pfam13707 290317006149 transposase; Provisional; Region: PRK06526 290317006150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006151 Walker A motif; other site 290317006152 ATP binding site [chemical binding]; other site 290317006153 Walker B motif; other site 290317006154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317006155 Integrase core domain; Region: rve; cl01316 290317006156 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006157 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 290317006158 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 290317006159 putative active site [active] 290317006160 putative NTP binding site [chemical binding]; other site 290317006161 putative nucleic acid binding site [nucleotide binding]; other site 290317006162 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006163 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006164 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 290317006165 Helix-turn-helix domains; Region: HTH; cl00088 290317006166 Helix-turn-helix domains; Region: HTH; cl00088 290317006167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290317006168 Integrase core domain; Region: rve; cl01316 290317006169 Integrase core domain; Region: rve_3; cl15866 290317006170 Protein of unknown function (DUF433); Region: DUF433; cl01030 290317006171 Winged helix-turn helix; Region: HTH_29; pfam13551 290317006172 Helix-turn-helix domains; Region: HTH; cl00088 290317006173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290317006174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290317006175 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290317006176 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 290317006177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290317006178 ATP binding site [chemical binding]; other site 290317006179 putative Mg++ binding site [ion binding]; other site 290317006180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290317006181 nucleotide binding region [chemical binding]; other site 290317006182 ATP-binding site [chemical binding]; other site 290317006183 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 290317006184 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317006185 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006186 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 290317006187 putative uracil binding site [chemical binding]; other site 290317006188 putative active site [active] 290317006189 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006190 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290317006191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006192 Walker A motif; other site 290317006193 ATP binding site [chemical binding]; other site 290317006194 Walker B motif; other site 290317006195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317006196 Integrase core domain; Region: rve; cl01316 290317006197 Helix-turn-helix domains; Region: HTH; cl00088 290317006198 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317006199 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317006200 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006201 Transposase IS200 like; Region: Y1_Tnp; cl00848 290317006202 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317006203 RES domain; Region: RES; cl02411 290317006204 Beta protein; Region: Beta_protein; pfam14350 290317006205 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 290317006206 Ycf46; Provisional; Region: ycf46; CHL00195 290317006207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006208 Walker A motif; other site 290317006209 ATP binding site [chemical binding]; other site 290317006210 Walker B motif; other site 290317006211 arginine finger; other site 290317006212 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 290317006213 Cell division protein FtsA; Region: FtsA; cl11496 290317006214 Sulfatase; Region: Sulfatase; cl10460 290317006215 HipA N-terminal domain; Region: Couple_hipA; cl11853 290317006216 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 290317006217 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290317006218 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290317006219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006220 NAD(P) binding site [chemical binding]; other site 290317006221 active site 290317006222 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 290317006223 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 290317006224 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290317006225 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 290317006226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 290317006228 Transposase; Region: DDE_Tnp_ISL3; pfam01610 290317006229 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290317006230 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290317006231 trimer interface [polypeptide binding]; other site 290317006232 putative metal binding site [ion binding]; other site 290317006233 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 290317006234 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 290317006235 Walker A/P-loop; other site 290317006236 ATP binding site [chemical binding]; other site 290317006237 Q-loop/lid; other site 290317006238 ABC transporter signature motif; other site 290317006239 Walker B; other site 290317006240 D-loop; other site 290317006241 H-loop/switch region; other site 290317006242 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 290317006243 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290317006244 B12 binding site [chemical binding]; other site 290317006245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317006246 FeS/SAM binding site; other site 290317006247 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 290317006248 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 290317006249 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290317006250 Zn2+ binding site [ion binding]; other site 290317006251 Mg2+ binding site [ion binding]; other site 290317006252 YtxH-like protein; Region: YtxH; cl02079 290317006253 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317006254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317006255 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 290317006256 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 290317006257 hinge; other site 290317006258 active site 290317006259 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 290317006260 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 290317006261 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290317006262 dimer interface [polypeptide binding]; other site 290317006263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317006264 catalytic residue [active] 290317006265 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290317006266 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 290317006267 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 290317006268 alanine racemase; Reviewed; Region: alr; PRK00053 290317006269 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290317006270 active site 290317006271 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290317006272 dimer interface [polypeptide binding]; other site 290317006273 substrate binding site [chemical binding]; other site 290317006274 catalytic residues [active] 290317006275 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 290317006276 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290317006277 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 290317006278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006279 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 290317006280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 290317006281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290317006282 FMN binding site [chemical binding]; other site 290317006283 active site 290317006284 catalytic residues [active] 290317006285 substrate binding site [chemical binding]; other site 290317006286 recombinase A; Provisional; Region: recA; PRK09354 290317006287 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290317006288 hexamer interface [polypeptide binding]; other site 290317006289 Walker A motif; other site 290317006290 ATP binding site [chemical binding]; other site 290317006291 Walker B motif; other site 290317006292 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 290317006293 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 290317006294 putative NADP binding site [chemical binding]; other site 290317006295 putative substrate binding site [chemical binding]; other site 290317006296 active site 290317006297 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290317006298 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290317006299 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290317006300 trigger factor; Region: tig; TIGR00115 290317006301 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290317006302 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290317006303 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 290317006304 dimerization interface [polypeptide binding]; other site 290317006305 active site 290317006306 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290317006307 active site 290317006308 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290317006309 catalytic center binding site [active] 290317006310 ATP binding site [chemical binding]; other site 290317006311 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290317006312 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290317006313 P loop; other site 290317006314 Nucleotide binding site [chemical binding]; other site 290317006315 DTAP/Switch II; other site 290317006316 Switch I; other site 290317006317 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 290317006318 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 290317006319 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290317006320 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290317006321 P loop; other site 290317006322 Nucleotide binding site [chemical binding]; other site 290317006323 DTAP/Switch II; other site 290317006324 Switch I; other site 290317006325 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 290317006326 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 290317006327 FAD binding pocket [chemical binding]; other site 290317006328 FAD binding motif [chemical binding]; other site 290317006329 phosphate binding motif [ion binding]; other site 290317006330 beta-alpha-beta structure motif; other site 290317006331 NAD binding pocket [chemical binding]; other site 290317006332 Iron coordination center [ion binding]; other site 290317006333 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290317006334 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290317006335 dimer interface [polypeptide binding]; other site 290317006336 ssDNA binding site [nucleotide binding]; other site 290317006337 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290317006338 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 290317006339 DNA polymerase III, delta subunit; Region: holA; TIGR01128 290317006340 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290317006341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006342 NAD(P) binding site [chemical binding]; other site 290317006343 active site 290317006344 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 290317006345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290317006346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290317006347 catalytic residue [active] 290317006348 transposase; Provisional; Region: PRK06526 290317006349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006350 Walker A motif; other site 290317006351 ATP binding site [chemical binding]; other site 290317006352 Walker B motif; other site 290317006353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317006354 Integrase core domain; Region: rve; cl01316 290317006355 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 290317006356 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290317006357 N-terminal plug; other site 290317006358 ligand-binding site [chemical binding]; other site 290317006359 magnesium chelatase, H subunit; Region: BchH; TIGR02025 290317006360 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290317006361 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290317006362 magnesium chelatase subunit H; Provisional; Region: PRK12493 290317006363 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 290317006364 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290317006365 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290317006366 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 290317006367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317006368 S-adenosylmethionine binding site [chemical binding]; other site 290317006369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006370 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 290317006371 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 290317006372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317006373 FeS/SAM binding site; other site 290317006374 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290317006375 putative dimer interface [polypeptide binding]; other site 290317006376 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 290317006377 GIY-YIG motif/motif A; other site 290317006378 putative active site [active] 290317006379 putative metal binding site [ion binding]; other site 290317006380 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317006381 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 290317006382 putative ADP-binding pocket [chemical binding]; other site 290317006383 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006384 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006385 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006386 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006387 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006388 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006389 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006390 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006391 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006392 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006393 Family description; Region: VCBS; pfam13517 290317006394 Family description; Region: VCBS; pfam13517 290317006395 Family description; Region: VCBS; pfam13517 290317006396 Family description; Region: VCBS; pfam13517 290317006397 Family description; Region: VCBS; pfam13517 290317006398 Family description; Region: VCBS; pfam13517 290317006399 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006400 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006401 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006402 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006403 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006404 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006405 transposase; Provisional; Region: PRK06526 290317006406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006407 Walker A motif; other site 290317006408 ATP binding site [chemical binding]; other site 290317006409 Walker B motif; other site 290317006410 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317006411 Integrase core domain; Region: rve; cl01316 290317006412 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317006413 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 290317006414 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317006415 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006416 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006417 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006418 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006419 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006420 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006421 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006422 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006423 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006424 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006425 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006426 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006427 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006428 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290317006429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 290317006430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 290317006431 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 290317006432 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 290317006433 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 290317006434 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 290317006435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290317006436 active site 290317006437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317006438 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 290317006439 nucleophilic elbow; other site 290317006440 catalytic triad; other site 290317006441 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006442 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006443 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006444 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006445 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006446 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006447 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006448 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006449 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006450 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 290317006451 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006452 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290317006453 Helix-turn-helix domains; Region: HTH; cl00088 290317006454 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 290317006455 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290317006456 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 290317006457 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 290317006458 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290317006459 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 290317006460 Substrate binding site; other site 290317006461 metal-binding site 290317006462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290317006463 active site 290317006464 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 290317006465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006466 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290317006467 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 290317006468 Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177 290317006469 Walker A/P-loop; other site 290317006470 ATP binding site [chemical binding]; other site 290317006471 Q-loop/lid; other site 290317006472 ABC transporter signature motif; other site 290317006473 Walker B; other site 290317006474 D-loop; other site 290317006475 H-loop/switch region; other site 290317006476 ABC-2 type transporter; Region: ABC2_membrane; cl11417 290317006477 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 290317006478 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 290317006479 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 290317006480 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 290317006481 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006482 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 290317006483 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006484 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006485 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006486 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006487 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006488 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 290317006489 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006490 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 290317006491 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290317006492 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155 290317006493 Transposase domain (DUF772); Region: DUF772; cl15789 290317006494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317006495 putative active site [active] 290317006496 heme pocket [chemical binding]; other site 290317006497 PAS domain S-box; Region: sensory_box; TIGR00229 290317006498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290317006499 PAS domain S-box; Region: sensory_box; TIGR00229 290317006500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317006501 putative active site [active] 290317006502 heme pocket [chemical binding]; other site 290317006503 PAS fold; Region: PAS_4; pfam08448 290317006504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317006505 putative active site [active] 290317006506 heme pocket [chemical binding]; other site 290317006507 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290317006508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317006509 putative active site [active] 290317006510 heme pocket [chemical binding]; other site 290317006511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290317006512 dimer interface [polypeptide binding]; other site 290317006513 phosphorylation site [posttranslational modification] 290317006514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317006515 ATP binding site [chemical binding]; other site 290317006516 Mg2+ binding site [ion binding]; other site 290317006517 G-X-G motif; other site 290317006518 Response regulator receiver domain; Region: Response_reg; pfam00072 290317006519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317006520 active site 290317006521 phosphorylation site [posttranslational modification] 290317006522 intermolecular recognition site; other site 290317006523 dimerization interface [polypeptide binding]; other site 290317006524 RF-1 domain; Region: RF-1; cl02875 290317006525 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 290317006526 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 290317006527 DNA-binding site [nucleotide binding]; DNA binding site 290317006528 RNA-binding motif; other site 290317006529 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 290317006530 structural tetrad; other site 290317006531 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 290317006532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290317006533 active site 290317006534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290317006535 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290317006536 ATP phosphoribosyltransferase; Region: HisG; cl15266 290317006537 HisG, C-terminal domain; Region: HisG_C; cl06867 290317006538 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 290317006539 putative active site [active] 290317006540 putative metal binding site [ion binding]; other site 290317006541 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 290317006542 UbiA prenyltransferase family; Region: UbiA; cl00337 290317006543 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340 290317006544 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290317006545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317006546 FeS/SAM binding site; other site 290317006547 TRAM domain; Region: TRAM; cl01282 290317006548 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290317006549 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290317006550 trimerization site [polypeptide binding]; other site 290317006551 active site 290317006552 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 290317006553 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290317006554 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 290317006555 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290317006556 catalytic residue [active] 290317006557 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290317006558 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290317006559 dimer interface [polypeptide binding]; other site 290317006560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317006561 catalytic residue [active] 290317006562 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290317006563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006564 NAD(P) binding site [chemical binding]; other site 290317006565 active site 290317006566 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 290317006567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 290317006568 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290317006569 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290317006570 active site 290317006571 multimer interface [polypeptide binding]; other site 290317006572 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290317006573 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 290317006574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 290317006575 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 290317006576 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 290317006577 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290317006578 active site 290317006579 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290317006580 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290317006581 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 290317006582 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 290317006583 active site 290317006584 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 290317006585 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 290317006586 HemN C-terminal domain; Region: HemN_C; pfam06969 290317006587 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 290317006588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317006589 active site 290317006590 motif I; other site 290317006591 motif II; other site 290317006592 glycogen synthase; Provisional; Region: PRK14098 290317006593 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 290317006594 ADP-binding pocket [chemical binding]; other site 290317006595 homodimer interface [polypeptide binding]; other site 290317006596 Bacterial Ig-like domain; Region: Big_5; cl01012 290317006597 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 290317006598 Heme NO binding; Region: HNOB; cl15268 290317006599 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 290317006600 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290317006601 active site 290317006602 catalytic site [active] 290317006603 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 290317006604 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 290317006605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317006606 S-adenosylmethionine binding site [chemical binding]; other site 290317006607 transposase; Provisional; Region: PRK06526 290317006608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006609 Walker A motif; other site 290317006610 ATP binding site [chemical binding]; other site 290317006611 Walker B motif; other site 290317006612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317006613 Integrase core domain; Region: rve; cl01316 290317006614 ATP adenylyltransferase; Region: ATP_transf; pfam09830 290317006615 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 290317006616 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 290317006617 P-loop; other site 290317006618 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 290317006619 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 290317006620 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290317006621 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290317006622 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 290317006623 Domain of unknown function DUF77; Region: DUF77; cl00307 290317006624 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290317006625 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290317006626 GDP-binding site [chemical binding]; other site 290317006627 ACT binding site; other site 290317006628 IMP binding site; other site 290317006629 Predicted GTPase [General function prediction only]; Region: COG0218 290317006630 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 290317006631 G1 box; other site 290317006632 GTP/Mg2+ binding site [chemical binding]; other site 290317006633 Switch I region; other site 290317006634 G2 box; other site 290317006635 G3 box; other site 290317006636 Switch II region; other site 290317006637 G4 box; other site 290317006638 G5 box; other site 290317006639 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290317006640 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290317006641 active site 290317006642 HIGH motif; other site 290317006643 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290317006644 KMSKS motif; other site 290317006645 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290317006646 tRNA binding surface [nucleotide binding]; other site 290317006647 anticodon binding site; other site 290317006648 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 290317006649 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 290317006650 Substrate binding site; other site 290317006651 Cupin domain; Region: Cupin_2; cl09118 290317006652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290317006653 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 290317006654 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290317006655 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290317006656 alphaNTD homodimer interface [polypeptide binding]; other site 290317006657 alphaNTD - beta interaction site [polypeptide binding]; other site 290317006658 alphaNTD - beta' interaction site [polypeptide binding]; other site 290317006659 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 290317006660 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290317006661 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290317006662 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290317006663 RNA binding surface [nucleotide binding]; other site 290317006664 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 290317006665 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 290317006666 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 290317006667 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290317006668 rRNA binding site [nucleotide binding]; other site 290317006669 predicted 30S ribosome binding site; other site 290317006670 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290317006671 active site 290317006672 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290317006673 SecY translocase; Region: SecY; pfam00344 290317006674 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 290317006675 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290317006676 23S rRNA binding site [nucleotide binding]; other site 290317006677 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290317006678 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290317006679 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290317006680 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290317006681 5S rRNA interface [nucleotide binding]; other site 290317006682 L27 interface [polypeptide binding]; other site 290317006683 23S rRNA interface [nucleotide binding]; other site 290317006684 L5 interface [polypeptide binding]; other site 290317006685 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290317006686 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290317006687 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290317006688 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 290317006689 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 290317006690 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290317006691 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290317006692 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290317006693 KOW motif; Region: KOW; cl00354 290317006694 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 290317006695 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 290317006696 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290317006697 putative translocon interaction site; other site 290317006698 23S rRNA interface [nucleotide binding]; other site 290317006699 signal recognition particle (SRP54) interaction site; other site 290317006700 L23 interface [polypeptide binding]; other site 290317006701 trigger factor interaction site; other site 290317006702 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290317006703 23S rRNA interface [nucleotide binding]; other site 290317006704 5S rRNA interface [nucleotide binding]; other site 290317006705 putative antibiotic binding site [chemical binding]; other site 290317006706 L25 interface [polypeptide binding]; other site 290317006707 L27 interface [polypeptide binding]; other site 290317006708 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290317006709 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290317006710 G-X-X-G motif; other site 290317006711 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290317006712 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290317006713 putative translocon binding site; other site 290317006714 protein-rRNA interface [nucleotide binding]; other site 290317006715 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 290317006716 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290317006717 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290317006718 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290317006719 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 290317006720 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 290317006721 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 290317006722 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 290317006723 elongation factor Tu; Reviewed; Region: PRK00049 290317006724 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290317006725 G1 box; other site 290317006726 GEF interaction site [polypeptide binding]; other site 290317006727 GTP/Mg2+ binding site [chemical binding]; other site 290317006728 Switch I region; other site 290317006729 G2 box; other site 290317006730 G3 box; other site 290317006731 Switch II region; other site 290317006732 G4 box; other site 290317006733 G5 box; other site 290317006734 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290317006735 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290317006736 Antibiotic Binding Site [chemical binding]; other site 290317006737 elongation factor G; Reviewed; Region: PRK00007 290317006738 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290317006739 G1 box; other site 290317006740 putative GEF interaction site [polypeptide binding]; other site 290317006741 GTP/Mg2+ binding site [chemical binding]; other site 290317006742 Switch I region; other site 290317006743 G2 box; other site 290317006744 G3 box; other site 290317006745 Switch II region; other site 290317006746 G4 box; other site 290317006747 G5 box; other site 290317006748 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290317006749 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290317006750 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290317006751 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 290317006752 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290317006753 S17 interaction site [polypeptide binding]; other site 290317006754 S8 interaction site; other site 290317006755 16S rRNA interaction site [nucleotide binding]; other site 290317006756 streptomycin interaction site [chemical binding]; other site 290317006757 23S rRNA interaction site [nucleotide binding]; other site 290317006758 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290317006759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317006760 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 290317006761 hypothetical protein; Provisional; Region: PRK10220 290317006762 PhnA protein; Region: PhnA; pfam03831 290317006763 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 290317006764 substrate binding site [chemical binding]; other site 290317006765 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 290317006766 MatE; Region: MatE; cl10513 290317006767 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 290317006768 putative homodimer interface [polypeptide binding]; other site 290317006769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006770 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290317006771 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290317006772 Probable Catalytic site; other site 290317006773 metal-binding site 290317006774 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 290317006775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317006776 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290317006777 dimerization domain swap beta strand [polypeptide binding]; other site 290317006778 regulatory protein interface [polypeptide binding]; other site 290317006779 active site 290317006780 regulatory phosphorylation site [posttranslational modification]; other site 290317006781 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 290317006782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290317006783 Coenzyme A binding pocket [chemical binding]; other site 290317006784 GTPase CgtA; Reviewed; Region: obgE; PRK12299 290317006785 GTP1/OBG; Region: GTP1_OBG; pfam01018 290317006786 Obg GTPase; Region: Obg; cd01898 290317006787 G1 box; other site 290317006788 GTP/Mg2+ binding site [chemical binding]; other site 290317006789 Switch I region; other site 290317006790 G2 box; other site 290317006791 G3 box; other site 290317006792 Switch II region; other site 290317006793 G4 box; other site 290317006794 G5 box; other site 290317006795 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 290317006796 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 290317006797 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 290317006798 GatB domain; Region: GatB_Yqey; cl11497 290317006799 Family of unknown function (DUF500); Region: DUF500; cl01109 290317006800 Clp amino terminal domain; Region: Clp_N; pfam02861 290317006801 Clp amino terminal domain; Region: Clp_N; pfam02861 290317006802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006803 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290317006804 Walker A motif; other site 290317006805 ATP binding site [chemical binding]; other site 290317006806 Walker B motif; other site 290317006807 arginine finger; other site 290317006808 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290317006809 metal ion-dependent adhesion site (MIDAS); other site 290317006810 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290317006811 metal ion-dependent adhesion site (MIDAS); other site 290317006812 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290317006813 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290317006814 metal ion-dependent adhesion site (MIDAS); other site 290317006815 MoxR-like ATPases [General function prediction only]; Region: COG0714 290317006816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317006817 Walker A motif; other site 290317006818 ATP binding site [chemical binding]; other site 290317006819 Walker B motif; other site 290317006820 arginine finger; other site 290317006821 UGMP family protein; Validated; Region: PRK09604 290317006822 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 290317006823 Preprotein translocase subunit; Region: YajC; cl00806 290317006824 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290317006825 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 290317006826 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290317006827 catalytic site [active] 290317006828 subunit interface [polypeptide binding]; other site 290317006829 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 290317006830 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 290317006831 homodimer interface [polypeptide binding]; other site 290317006832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317006833 catalytic residue [active] 290317006834 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 290317006835 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290317006836 B12 binding site [chemical binding]; other site 290317006837 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290317006838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317006839 FeS/SAM binding site; other site 290317006840 Cytochrome c; Region: Cytochrom_C; cl11414 290317006841 Cytochrome c; Region: Cytochrom_C; cl11414 290317006842 PQ loop repeat; Region: PQ-loop; cl12056 290317006843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317006844 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 290317006845 Oxygen tolerance; Region: BatD; pfam13584 290317006846 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290317006847 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290317006848 dimer interface [polypeptide binding]; other site 290317006849 putative functional site; other site 290317006850 putative MPT binding site; other site 290317006851 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 290317006852 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 290317006853 trimer interface [polypeptide binding]; other site 290317006854 dimer interface [polypeptide binding]; other site 290317006855 putative active site [active] 290317006856 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290317006857 MPT binding site; other site 290317006858 trimer interface [polypeptide binding]; other site 290317006859 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290317006860 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 290317006861 active site 290317006862 catalytic site [active] 290317006863 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490 290317006864 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 290317006865 Walker A motif; other site 290317006866 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 290317006867 GTP binding site; other site 290317006868 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290317006869 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 290317006870 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290317006871 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 290317006872 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290317006873 putative metal binding residues [ion binding]; other site 290317006874 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290317006875 metal binding site 2 [ion binding]; metal-binding site 290317006876 putative DNA binding helix; other site 290317006877 metal binding site 1 [ion binding]; metal-binding site 290317006878 dimer interface [polypeptide binding]; other site 290317006879 structural Zn2+ binding site [ion binding]; other site 290317006880 2-isopropylmalate synthase; Validated; Region: PRK03739 290317006881 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 290317006882 active site 290317006883 catalytic residues [active] 290317006884 metal binding site [ion binding]; metal-binding site 290317006885 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 290317006886 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006887 GIY-YIG motif/motif A; other site 290317006888 putative active site [active] 290317006889 putative metal binding site [ion binding]; other site 290317006890 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006891 GIY-YIG motif/motif A; other site 290317006892 putative active site [active] 290317006893 putative metal binding site [ion binding]; other site 290317006894 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006895 GIY-YIG motif/motif A; other site 290317006896 putative active site [active] 290317006897 putative metal binding site [ion binding]; other site 290317006898 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006899 GIY-YIG motif/motif A; other site 290317006900 putative active site [active] 290317006901 putative metal binding site [ion binding]; other site 290317006902 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006903 GIY-YIG motif/motif A; other site 290317006904 putative active site [active] 290317006905 putative metal binding site [ion binding]; other site 290317006906 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006907 GIY-YIG motif/motif A; other site 290317006908 putative active site [active] 290317006909 putative metal binding site [ion binding]; other site 290317006910 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006911 GIY-YIG motif/motif A; other site 290317006912 putative active site [active] 290317006913 putative metal binding site [ion binding]; other site 290317006914 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 290317006915 GIY-YIG motif/motif A; other site 290317006916 putative active site [active] 290317006917 putative metal binding site [ion binding]; other site 290317006918 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 290317006919 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 290317006920 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 290317006921 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290317006922 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290317006923 dimer interface [polypeptide binding]; other site 290317006924 active site 290317006925 CoA binding pocket [chemical binding]; other site 290317006926 Acyl transferase domain; Region: Acyl_transf_1; cl08282 290317006927 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290317006928 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 290317006929 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290317006930 NAD(P) binding site [chemical binding]; other site 290317006931 homotetramer interface [polypeptide binding]; other site 290317006932 homodimer interface [polypeptide binding]; other site 290317006933 active site 290317006934 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290317006935 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290317006936 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290317006937 dimer interface [polypeptide binding]; other site 290317006938 active site 290317006939 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 290317006940 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 290317006941 dimerization interface [polypeptide binding]; other site 290317006942 active site 290317006943 metal binding site [ion binding]; metal-binding site 290317006944 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 290317006945 dsRNA binding site [nucleotide binding]; other site 290317006946 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 290317006947 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290317006948 tetramer interface [polypeptide binding]; other site 290317006949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317006950 catalytic residue [active] 290317006951 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290317006952 active site 290317006953 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290317006954 nucleoside/Zn binding site; other site 290317006955 dimer interface [polypeptide binding]; other site 290317006956 catalytic motif [active] 290317006957 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290317006958 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290317006959 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 290317006960 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290317006961 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 290317006962 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 290317006963 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 290317006964 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290317006965 active site 290317006966 dimer interface [polypeptide binding]; other site 290317006967 motif 1; other site 290317006968 motif 2; other site 290317006969 motif 3; other site 290317006970 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290317006971 anticodon binding site; other site 290317006972 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 290317006973 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290317006974 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290317006975 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 290317006976 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290317006977 23S rRNA binding site [nucleotide binding]; other site 290317006978 L21 binding site [polypeptide binding]; other site 290317006979 L13 binding site [polypeptide binding]; other site 290317006980 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290317006981 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290317006982 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290317006983 dimer interface [polypeptide binding]; other site 290317006984 motif 1; other site 290317006985 active site 290317006986 motif 2; other site 290317006987 motif 3; other site 290317006988 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290317006989 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290317006990 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290317006991 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 290317006992 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290317006993 dimer interface [polypeptide binding]; other site 290317006994 ssDNA binding site [nucleotide binding]; other site 290317006995 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290317006996 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 290317006997 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290317006998 putative catalytic site [active] 290317006999 putative metal binding site [ion binding]; other site 290317007000 putative phosphate binding site [ion binding]; other site 290317007001 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290317007002 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290317007003 putative active site [active] 290317007004 Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968 290317007005 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290317007006 active site 290317007007 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 290317007008 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290317007009 4Fe-4S binding domain; Region: Fer4; cl02805 290317007010 Cysteine-rich domain; Region: CCG; pfam02754 290317007011 Cysteine-rich domain; Region: CCG; pfam02754 290317007012 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290317007013 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290317007014 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 290317007015 active site 290317007016 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 290317007017 Ligand binding site [chemical binding]; other site 290317007018 Electron transfer flavoprotein domain; Region: ETF; pfam01012 290317007019 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 290317007020 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 290317007021 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290317007022 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290317007023 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290317007024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317007025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007026 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 290317007027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290317007028 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290317007029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317007030 TPR motif; other site 290317007031 binding surface 290317007032 TPR repeat; Region: TPR_11; pfam13414 290317007033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317007034 binding surface 290317007035 TPR motif; other site 290317007036 TPR repeat; Region: TPR_11; pfam13414 290317007037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290317007038 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290317007039 metal-binding site [ion binding] 290317007040 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290317007041 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317007042 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290317007043 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290317007044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 290317007045 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 290317007046 Predicted esterase [General function prediction only]; Region: COG0400 290317007047 trehalose synthase; Region: treS_nterm; TIGR02456 290317007048 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 290317007049 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 290317007050 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 290317007051 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 290317007052 active site 290317007053 homodimer interface [polypeptide binding]; other site 290317007054 catalytic site [active] 290317007055 acceptor binding site [chemical binding]; other site 290317007056 peptide chain release factor 2; Validated; Region: prfB; PRK00578 290317007057 RF-1 domain; Region: RF-1; cl02875 290317007058 RF-1 domain; Region: RF-1; cl02875 290317007059 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 290317007060 active site 290317007061 metal binding site [ion binding]; metal-binding site 290317007062 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290317007063 competence damage-inducible protein A; Provisional; Region: PRK00549 290317007064 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 290317007065 putative MPT binding site; other site 290317007066 Competence-damaged protein; Region: CinA; cl00666 290317007067 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 290317007068 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 290317007069 putative catalytic residues [active] 290317007070 putative nucleotide binding site [chemical binding]; other site 290317007071 putative aspartate binding site [chemical binding]; other site 290317007072 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 290317007073 dimer interface [polypeptide binding]; other site 290317007074 putative threonine allosteric regulatory site; other site 290317007075 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 290317007076 putative threonine allosteric regulatory site; other site 290317007077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007078 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290317007079 ATP synthase; Region: ATP-synt; cl00365 290317007080 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 290317007081 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290317007082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 290317007083 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290317007084 beta subunit interaction interface [polypeptide binding]; other site 290317007085 Walker A motif; other site 290317007086 ATP binding site [chemical binding]; other site 290317007087 Walker B motif; other site 290317007088 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290317007089 homoserine kinase; Provisional; Region: PRK01212 290317007090 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290317007091 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290317007092 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 290317007093 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 290317007094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317007095 catalytic residue [active] 290317007096 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290317007097 putative acyl-acceptor binding pocket; other site 290317007098 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290317007099 homopentamer interface [polypeptide binding]; other site 290317007100 active site 290317007101 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290317007102 dimer interface [polypeptide binding]; other site 290317007103 active site 290317007104 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290317007105 Ligand Binding Site [chemical binding]; other site 290317007106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290317007107 Ligand Binding Site [chemical binding]; other site 290317007108 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290317007109 catalytic triad [active] 290317007110 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 290317007111 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 290317007112 active site 290317007113 homodimer interface [polypeptide binding]; other site 290317007114 OstA-like protein; Region: OstA_2; pfam13100 290317007115 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 290317007116 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 290317007117 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290317007118 Recombination protein O N terminal; Region: RecO_N; cl15812 290317007119 Recombination protein O C terminal; Region: RecO_C; pfam02565 290317007120 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290317007121 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290317007122 inhibitor-cofactor binding pocket; inhibition site 290317007123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290317007124 catalytic residue [active] 290317007125 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 290317007126 CrcB-like protein; Region: CRCB; cl09114 290317007127 thiosulfate reductase PhsA; Provisional; Region: PRK15488 290317007128 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 290317007129 putative [Fe4-S4] binding site [ion binding]; other site 290317007130 putative molybdopterin cofactor binding site [chemical binding]; other site 290317007131 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 290317007132 putative molybdopterin cofactor binding site; other site 290317007133 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 290317007134 4Fe-4S binding domain; Region: Fer4; cl02805 290317007135 Polysulphide reductase, NrfD; Region: NrfD; cl01295 290317007136 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 290317007137 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 290317007138 SOUL heme-binding protein; Region: SOUL; pfam04832 290317007139 transposase; Provisional; Region: PRK06526 290317007140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317007141 Walker A motif; other site 290317007142 ATP binding site [chemical binding]; other site 290317007143 Walker B motif; other site 290317007144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317007145 Integrase core domain; Region: rve; cl01316 290317007146 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290317007147 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 290317007148 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 290317007149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290317007150 active site 290317007151 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 290317007152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007153 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 290317007154 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 290317007155 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 290317007156 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 290317007157 NeuB family; Region: NeuB; cl00496 290317007158 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290317007159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317007160 Walker A motif; other site 290317007161 ATP binding site [chemical binding]; other site 290317007162 Walker B motif; other site 290317007163 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 290317007164 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290317007165 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290317007166 catalytic core [active] 290317007167 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290317007168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007169 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290317007170 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 290317007171 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290317007172 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290317007173 dimerization interface [polypeptide binding]; other site 290317007174 putative ATP binding site [chemical binding]; other site 290317007175 aspartate kinase III; Validated; Region: PRK09084 290317007176 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 290317007177 nucleotide binding site [chemical binding]; other site 290317007178 substrate binding site [chemical binding]; other site 290317007179 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290317007180 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 290317007181 NlpC/P60 family; Region: NLPC_P60; cl11438 290317007182 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 290317007183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317007184 S-adenosylmethionine binding site [chemical binding]; other site 290317007185 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 290317007186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007187 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 290317007188 AMP-binding enzyme; Region: AMP-binding; cl15778 290317007189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290317007190 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 290317007191 glycerol kinase; Provisional; Region: glpK; PRK00047 290317007192 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 290317007193 N- and C-terminal domain interface [polypeptide binding]; other site 290317007194 active site 290317007195 MgATP binding site [chemical binding]; other site 290317007196 catalytic site [active] 290317007197 metal binding site [ion binding]; metal-binding site 290317007198 glycerol binding site [chemical binding]; other site 290317007199 homotetramer interface [polypeptide binding]; other site 290317007200 homodimer interface [polypeptide binding]; other site 290317007201 FBP binding site [chemical binding]; other site 290317007202 protein IIAGlc interface [polypeptide binding]; other site 290317007203 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 290317007204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317007205 motif II; other site 290317007206 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 290317007207 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 290317007208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290317007209 FeS/SAM binding site; other site 290317007210 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290317007211 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 290317007212 active site 290317007213 metal binding site [ion binding]; metal-binding site 290317007214 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 290317007215 transcriptional activator RfaH; Region: RfaH; TIGR01955 290317007216 KOW motif; Region: KOW; cl00354 290317007217 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 290317007218 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 290317007219 Substrate binding site; other site 290317007220 Cupin domain; Region: Cupin_2; cl09118 290317007221 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290317007222 putative active site [active] 290317007223 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 290317007224 active site 290317007225 ADP/pyrophosphate binding site [chemical binding]; other site 290317007226 dimerization interface [polypeptide binding]; other site 290317007227 allosteric effector site; other site 290317007228 fructose-1,6-bisphosphate binding site; other site 290317007229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290317007230 active site 290317007231 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 290317007232 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290317007233 Divergent AAA domain; Region: AAA_4; pfam04326 290317007234 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290317007235 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290317007236 glutaminase active site [active] 290317007237 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290317007238 dimer interface [polypeptide binding]; other site 290317007239 active site 290317007240 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290317007241 dimer interface [polypeptide binding]; other site 290317007242 active site 290317007243 OpgC protein; Region: OpgC_C; cl00792 290317007244 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 290317007245 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 290317007246 putative trimer interface [polypeptide binding]; other site 290317007247 putative CoA binding site [chemical binding]; other site 290317007248 GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472 290317007249 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 290317007250 NADP-binding site; other site 290317007251 homotetramer interface [polypeptide binding]; other site 290317007252 substrate binding site [chemical binding]; other site 290317007253 homodimer interface [polypeptide binding]; other site 290317007254 active site 290317007255 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 290317007256 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 290317007257 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 290317007258 NADP binding site [chemical binding]; other site 290317007259 active site 290317007260 putative substrate binding site [chemical binding]; other site 290317007261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 290317007262 Integrase core domain; Region: rve; cl01316 290317007263 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317007264 Bacterial sugar transferase; Region: Bac_transf; cl00939 290317007265 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290317007266 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 290317007267 putative NAD(P) binding site [chemical binding]; other site 290317007268 active site 290317007269 putative substrate binding site [chemical binding]; other site 290317007270 polysaccharide deactylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 290317007271 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 290317007272 Domain of unknown function (DUF3473); Region: DUF3473; pfam11959 290317007273 hypothetical protein; Provisional; Region: PRK06849 290317007274 ATP-grasp domain; Region: ATP-grasp_4; cl03087 290317007275 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 290317007276 trimer interface [polypeptide binding]; other site 290317007277 active site 290317007278 substrate binding site [chemical binding]; other site 290317007279 CoA binding site [chemical binding]; other site 290317007280 Integrase core domain; Region: rve; cl01316 290317007281 MatE; Region: MatE; cl10513 290317007282 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 290317007283 Winged helix-turn helix; Region: HTH_29; pfam13551 290317007284 Helix-turn-helix domains; Region: HTH; cl00088 290317007285 Helix-turn-helix domains; Region: HTH; cl00088 290317007286 Integrase core domain; Region: rve; cl01316 290317007287 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 290317007288 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 290317007289 putative active site [active] 290317007290 putative NTP binding site [chemical binding]; other site 290317007291 putative nucleic acid binding site [nucleotide binding]; other site 290317007292 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 290317007293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290317007294 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290317007295 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 290317007296 metal-binding site 290317007297 Transposase domain (DUF772); Region: DUF772; cl15789 290317007298 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290317007299 Transposase domain (DUF772); Region: DUF772; cl15789 290317007300 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 290317007301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007302 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 290317007303 NAD(P) binding site [chemical binding]; other site 290317007304 homodimer interface [polypeptide binding]; other site 290317007305 substrate binding site [chemical binding]; other site 290317007306 active site 290317007307 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 290317007308 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 290317007309 oligomeric interface; other site 290317007310 putative active site [active] 290317007311 homodimer interface [polypeptide binding]; other site 290317007312 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 290317007313 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 290317007314 Protein of unknown function (DUF433); Region: DUF433; cl01030 290317007315 YokU-like protein; Region: YokU; cl15819 290317007316 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 290317007317 ORF6N domain; Region: ORF6N; pfam10543 290317007318 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 290317007319 putative active site [active] 290317007320 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 290317007321 Chain length determinant protein; Region: Wzz; cl15801 290317007322 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290317007323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 290317007324 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 290317007325 transposase; Provisional; Region: PRK06526 290317007326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317007327 Walker A motif; other site 290317007328 ATP binding site [chemical binding]; other site 290317007329 Walker B motif; other site 290317007330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317007331 Integrase core domain; Region: rve; cl01316 290317007332 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 290317007333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290317007334 Integrase core domain; Region: rve; cl01316 290317007335 transposase; Provisional; Region: PRK06526 290317007336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317007337 Walker A motif; other site 290317007338 ATP binding site [chemical binding]; other site 290317007339 Walker B motif; other site 290317007340 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290317007341 CTP synthetase; Validated; Region: pyrG; PRK05380 290317007342 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290317007343 Catalytic site [active] 290317007344 active site 290317007345 UTP binding site [chemical binding]; other site 290317007346 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290317007347 active site 290317007348 putative oxyanion hole; other site 290317007349 catalytic triad [active] 290317007350 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 290317007351 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 290317007352 DNA gyrase subunit A; Validated; Region: PRK05560 290317007353 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 290317007354 CAP-like domain; other site 290317007355 active site 290317007356 primary dimer interface [polypeptide binding]; other site 290317007357 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290317007358 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290317007359 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290317007360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290317007361 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290317007362 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290317007363 Oligomerisation domain; Region: Oligomerisation; cl00519 290317007364 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 290317007365 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 290317007366 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 290317007367 ScpA/B protein; Region: ScpA_ScpB; cl00598 290317007368 TPR repeat; Region: TPR_11; pfam13414 290317007369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317007370 binding surface 290317007371 TPR motif; other site 290317007372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290317007373 binding surface 290317007374 TPR motif; other site 290317007375 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 290317007376 active site 290317007377 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290317007378 Nitrogen regulatory protein P-II; Region: P-II; cl00412 290317007379 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 290317007380 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 290317007381 RNA/DNA binding site [nucleotide binding]; other site 290317007382 RRM dimerization site [polypeptide binding]; other site 290317007383 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 290317007384 Ferritin-like domain; Region: Ferritin; pfam00210 290317007385 diiron binding motif [ion binding]; other site 290317007386 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 290317007387 TIGR01777 family protein; Region: yfcH 290317007388 putative NAD(P) binding site [chemical binding]; other site 290317007389 putative active site [active] 290317007390 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290317007391 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290317007392 glutaminase active site [active] 290317007393 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290317007394 dimer interface [polypeptide binding]; other site 290317007395 active site 290317007396 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290317007397 dimer interface [polypeptide binding]; other site 290317007398 active site 290317007399 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 290317007400 active site 290317007401 dimer interface [polypeptide binding]; other site 290317007402 FtsH Extracellular; Region: FtsH_ext; pfam06480 290317007403 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 290317007404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290317007405 Walker B motif; other site 290317007406 arginine finger; other site 290317007407 Peptidase family M41; Region: Peptidase_M41; pfam01434 290317007408 Acylphosphatase; Region: Acylphosphatase; cl00551 290317007409 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290317007410 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290317007411 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290317007412 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290317007413 RIP metalloprotease RseP; Region: TIGR00054 290317007414 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290317007415 active site 290317007416 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 290317007417 protein binding site [polypeptide binding]; other site 290317007418 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290317007419 protein binding site [polypeptide binding]; other site 290317007420 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290317007421 putative substrate binding region [chemical binding]; other site 290317007422 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290317007423 RF-1 domain; Region: RF-1; cl02875 290317007424 RF-1 domain; Region: RF-1; cl02875 290317007425 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 290317007426 putative FMN binding site [chemical binding]; other site 290317007427 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290317007428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290317007429 active site 290317007430 phosphorylation site [posttranslational modification] 290317007431 intermolecular recognition site; other site 290317007432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290317007433 DNA binding residues [nucleotide binding] 290317007434 dimerization interface [polypeptide binding]; other site 290317007435 PAS domain S-box; Region: sensory_box; TIGR00229 290317007436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290317007437 putative active site [active] 290317007438 heme pocket [chemical binding]; other site 290317007439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290317007440 Histidine kinase; Region: HisKA_3; pfam07730 290317007441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290317007442 ATP binding site [chemical binding]; other site 290317007443 Mg2+ binding site [ion binding]; other site 290317007444 G-X-G motif; other site 290317007445 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290317007446 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 290317007447 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290317007448 dimer interface [polypeptide binding]; other site 290317007449 active site 290317007450 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290317007451 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 290317007452 Esterase/lipase [General function prediction only]; Region: COG1647 290317007453 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 290317007454 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 290317007455 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 290317007456 active site 290317007457 intersubunit interactions; other site 290317007458 catalytic residue [active] 290317007459 Deoxyhypusine synthase; Region: DS; cl00826 290317007460 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290317007461 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290317007462 active site 290317007463 HIGH motif; other site 290317007464 dimer interface [polypeptide binding]; other site 290317007465 KMSKS motif; other site 290317007466 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290317007467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290317007468 motif II; other site 290317007469 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 290317007470 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 290317007471 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290317007472 active site 290317007473 HIGH motif; other site 290317007474 KMSK motif region; other site 290317007475 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290317007476 tRNA binding surface [nucleotide binding]; other site 290317007477 anticodon binding site; other site 290317007478 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290317007479 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290317007480 active site 290317007481 (T/H)XGH motif; other site 290317007482 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 290317007483 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 290317007484 Plant ATP synthase F0; Region: YMF19; cl07975 290317007485 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 290317007486 Plant ATP synthase F0; Region: YMF19; cl07975 290317007487 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290317007488 ATP synthase subunit C; Region: ATP-synt_C; cl00466 290317007489 ATP synthase A chain; Region: ATP-synt_A; cl00413 290317007490 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 290317007491 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 290317007492 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 290317007493 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 290317007494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 290317007495 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 290317007496 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 290317007497 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 290317007498 cell division protein FtsZ; Validated; Region: PRK09330 290317007499 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290317007500 nucleotide binding site [chemical binding]; other site 290317007501 SulA interaction site; other site 290317007502 cell division protein FtsA; Region: ftsA; TIGR01174 290317007503 Cell division protein FtsA; Region: FtsA; cl11496 290317007504 Cell division protein FtsA; Region: FtsA; cl11496 290317007505 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 290317007506 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290317007507 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290317007508 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290317007509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290317007510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290317007511 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 290317007512 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290317007513 active site 290317007514 homodimer interface [polypeptide binding]; other site 290317007515 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 290317007516 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 290317007517 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290317007518 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290317007519 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290317007520 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290317007521 Mg++ binding site [ion binding]; other site 290317007522 putative catalytic motif [active] 290317007523 putative substrate binding site [chemical binding]; other site 290317007524 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290317007525 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 290317007526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290317007527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290317007528 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290317007529 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290317007530 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 290317007531 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290317007532 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 290317007533 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290317007534 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 290317007535 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 290317007536 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 290317007537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290317007538 cell division protein MraZ; Reviewed; Region: PRK00326 290317007539 MraZ protein; Region: MraZ; pfam02381 290317007540 MraZ protein; Region: MraZ; pfam02381 290317007541 YacP-like NYN domain; Region: NYN_YacP; cl01491 290317007542 Chorismate mutase type II; Region: CM_2; cl00693 290317007543 YceG-like family; Region: YceG; pfam02618 290317007544 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 290317007545 dimerization interface [polypeptide binding]; other site 290317007546 Phosphoglycerate kinase; Region: PGK; pfam00162 290317007547 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 290317007548 substrate binding site [chemical binding]; other site 290317007549 hinge regions; other site 290317007550 ADP binding site [chemical binding]; other site 290317007551 catalytic site [active] 290317007552 Rhomboid family; Region: Rhomboid; cl11446 290317007553 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 290317007554 TRAM domain; Region: TRAM; cl01282 290317007555 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 290317007556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290317007557 S-adenosylmethionine binding site [chemical binding]; other site 290317007558 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 290317007559 fructokinase; Reviewed; Region: PRK09557 290317007560 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 290317007561 active site 290317007562 membrane protein insertase; Provisional; Region: PRK01318 290317007563 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 290317007564 Haemolytic domain; Region: Haemolytic; cl00506 290317007565 Ribonuclease P; Region: Ribonuclease_P; cl00457 290317007566 Ribosomal protein L34; Region: Ribosomal_L34; cl00370