-- dump date   	20120504_141839
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
517418000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
517418000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
517418000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418000004	Walker A motif; other site
517418000005	ATP binding site [chemical binding]; other site
517418000006	Walker B motif; other site
517418000007	arginine finger; other site
517418000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
517418000009	DnaA box-binding interface [nucleotide binding]; other site
517418000010	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
517418000011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418000012	Walker A motif; other site
517418000013	ATP binding site [chemical binding]; other site
517418000014	Walker B motif; other site
517418000015	arginine finger; other site
517418000016	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
517418000017	DNA gyrase subunit A; Validated; Region: PRK05560
517418000018	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
517418000019	CAP-like domain; other site
517418000020	active site
517418000021	primary dimer interface [polypeptide binding]; other site
517418000022	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517418000023	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517418000024	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517418000025	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517418000026	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517418000027	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517418000028	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
517418000029	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
517418000030	Walker A/P-loop; other site
517418000031	ATP binding site [chemical binding]; other site
517418000032	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
517418000033	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
517418000034	ABC transporter signature motif; other site
517418000035	Walker B; other site
517418000036	D-loop; other site
517418000037	H-loop/switch region; other site
517418000038	beta-D-glucuronidase; Provisional; Region: PRK10150
517418000039	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
517418000040	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
517418000041	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
517418000042	Yip1 domain; Region: Yip1; cl12048
517418000043	Phospholipid methyltransferase; Region: PEMT; cl00763
517418000044	CAAX protease self-immunity; Region: Abi; cl00558
517418000045	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
517418000046	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
517418000047	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
517418000048	active site
517418000049	phosphorylation site [posttranslational modification]
517418000050	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
517418000051	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
517418000052	dimer interface [polypeptide binding]; other site
517418000053	motif 1; other site
517418000054	active site
517418000055	motif 2; other site
517418000056	motif 3; other site
517418000057	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
517418000058	anticodon binding site; other site
517418000059	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517418000060	ligand binding site [chemical binding]; other site
517418000061	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
517418000062	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418000063	Walker A/P-loop; other site
517418000064	ATP binding site [chemical binding]; other site
517418000065	Q-loop/lid; other site
517418000066	ABC transporter signature motif; other site
517418000067	Walker B; other site
517418000068	D-loop; other site
517418000069	H-loop/switch region; other site
517418000070	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
517418000071	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418000072	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418000073	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517418000074	Response regulator receiver domain; Region: Response_reg; pfam00072
517418000075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418000076	active site
517418000077	phosphorylation site [posttranslational modification]
517418000078	intermolecular recognition site; other site
517418000079	dimerization interface [polypeptide binding]; other site
517418000080	PAS domain; Region: PAS_9; pfam13426
517418000081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000082	putative active site [active]
517418000083	heme pocket [chemical binding]; other site
517418000084	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
517418000085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418000086	dimer interface [polypeptide binding]; other site
517418000087	phosphorylation site [posttranslational modification]
517418000088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418000089	ATP binding site [chemical binding]; other site
517418000090	Mg2+ binding site [ion binding]; other site
517418000091	G-X-G motif; other site
517418000092	Response regulator receiver domain; Region: Response_reg; pfam00072
517418000093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418000094	active site
517418000095	phosphorylation site [posttranslational modification]
517418000096	intermolecular recognition site; other site
517418000097	dimerization interface [polypeptide binding]; other site
517418000098	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
517418000099	Response regulator receiver domain; Region: Response_reg; pfam00072
517418000100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418000101	active site
517418000102	phosphorylation site [posttranslational modification]
517418000103	intermolecular recognition site; other site
517418000104	dimerization interface [polypeptide binding]; other site
517418000105	PAS fold; Region: PAS_3; pfam08447
517418000106	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
517418000107	GAF domain; Region: GAF; cl15785
517418000108	PAS fold; Region: PAS; pfam00989
517418000109	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000110	putative active site [active]
517418000111	heme pocket [chemical binding]; other site
517418000112	PAS fold; Region: PAS_3; pfam08447
517418000113	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000114	putative active site [active]
517418000115	heme pocket [chemical binding]; other site
517418000116	putative diguanylate cyclase; Provisional; Region: PRK09776
517418000117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000118	putative active site [active]
517418000119	heme pocket [chemical binding]; other site
517418000120	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
517418000121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000122	putative active site [active]
517418000123	heme pocket [chemical binding]; other site
517418000124	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418000125	dimer interface [polypeptide binding]; other site
517418000126	phosphorylation site [posttranslational modification]
517418000127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418000128	ATP binding site [chemical binding]; other site
517418000129	Mg2+ binding site [ion binding]; other site
517418000130	G-X-G motif; other site
517418000131	KWG Leptospira; Region: KWG; pfam07656
517418000132	KWG Leptospira; Region: KWG; pfam07656
517418000133	KWG Leptospira; Region: KWG; pfam07656
517418000134	KWG Leptospira; Region: KWG; pfam07656
517418000135	KWG Leptospira; Region: KWG; pfam07656
517418000136	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
517418000137	active site
517418000138	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
517418000139	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
517418000140	inhibitor-cofactor binding pocket; inhibition site
517418000141	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418000142	catalytic residue [active]
517418000143	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418000144	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418000145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418000146	binding surface
517418000147	TPR motif; other site
517418000148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418000149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418000150	binding surface
517418000151	TPR motif; other site
517418000152	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418000153	metal binding site [ion binding]; metal-binding site
517418000154	active site
517418000155	I-site; other site
517418000156	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
517418000157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000158	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
517418000159	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
517418000160	hypothetical protein; Validated; Region: PRK07883
517418000161	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
517418000162	active site
517418000163	substrate binding site [chemical binding]; other site
517418000164	catalytic site [active]
517418000165	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
517418000166	GIY-YIG motif/motif A; other site
517418000167	active site
517418000168	catalytic site [active]
517418000169	putative DNA binding site [nucleotide binding]; other site
517418000170	metal binding site [ion binding]; metal-binding site
517418000171	Predicted methyltransferases [General function prediction only]; Region: COG0313
517418000172	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418000173	Pantoate-beta-alanine ligase; Region: PanC; cd00560
517418000174	pantoate--beta-alanine ligase; Region: panC; TIGR00018
517418000175	active site
517418000176	ATP-binding site [chemical binding]; other site
517418000177	pantoate-binding site; other site
517418000178	HXXH motif; other site
517418000179	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
517418000180	intersubunit interface [polypeptide binding]; other site
517418000181	active site
517418000182	Zn2+ binding site [ion binding]; other site
517418000183	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
517418000184	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
517418000185	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
517418000186	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
517418000187	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
517418000188	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
517418000189	DNA binding site [nucleotide binding]
517418000190	Int/Topo IB signature motif; other site
517418000191	active site
517418000192	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
517418000193	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517418000194	catalytic residues [active]
517418000195	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
517418000196	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
517418000197	phosphoserine phosphatase SerB; Region: serB; TIGR00338
517418000198	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418000199	motif II; other site
517418000200	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
517418000201	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
517418000202	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
517418000203	Helix-turn-helix domains; Region: HTH; cl00088
517418000204	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
517418000205	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418000206	N-terminal plug; other site
517418000207	ligand-binding site [chemical binding]; other site
517418000208	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
517418000209	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
517418000210	NAD binding site [chemical binding]; other site
517418000211	homodimer interface [polypeptide binding]; other site
517418000212	active site
517418000213	substrate binding site [chemical binding]; other site
517418000214	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
517418000215	MPN+ (JAMM) motif; other site
517418000216	Zinc-binding site [ion binding]; other site
517418000217	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
517418000218	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
517418000219	dimer interface [polypeptide binding]; other site
517418000220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418000221	catalytic residue [active]
517418000222	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
517418000223	MPN+ (JAMM) motif; other site
517418000224	Zinc-binding site [ion binding]; other site
517418000225	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
517418000226	recombinase A; Provisional; Region: recA; PRK09354
517418000227	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
517418000228	hexamer interface [polypeptide binding]; other site
517418000229	Walker A motif; other site
517418000230	ATP binding site [chemical binding]; other site
517418000231	Walker B motif; other site
517418000232	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
517418000233	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
517418000234	putative catalytic residue [active]
517418000235	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
517418000236	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
517418000237	putative NADP binding site [chemical binding]; other site
517418000238	putative substrate binding site [chemical binding]; other site
517418000239	active site
517418000240	pyruvate carboxylase subunit B; Validated; Region: PRK09282
517418000241	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
517418000242	carboxyltransferase (CT) interaction site; other site
517418000243	biotinylation site [posttranslational modification]; other site
517418000244	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
517418000245	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418000246	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418000247	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418000248	chaperone protein DnaJ; Provisional; Region: PRK14299
517418000249	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
517418000250	HSP70 interaction site [polypeptide binding]; other site
517418000251	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
517418000252	substrate binding site [polypeptide binding]; other site
517418000253	dimer interface [polypeptide binding]; other site
517418000254	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
517418000255	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517418000256	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
517418000257	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
517418000258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517418000259	ATP binding site [chemical binding]; other site
517418000260	putative Mg++ binding site [ion binding]; other site
517418000261	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418000262	nucleotide binding region [chemical binding]; other site
517418000263	ATP-binding site [chemical binding]; other site
517418000264	TRCF domain; Region: TRCF; cl04088
517418000265	Oligomerisation domain; Region: Oligomerisation; cl00519
517418000266	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
517418000267	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
517418000268	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
517418000269	active site
517418000270	metal binding site [ion binding]; metal-binding site
517418000271	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
517418000272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418000273	FeS/SAM binding site; other site
517418000274	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
517418000275	substrate binding site [chemical binding]; other site
517418000276	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
517418000277	FMN binding site [chemical binding]; other site
517418000278	dimer interface [polypeptide binding]; other site
517418000279	Domain of unknown function (DUF697); Region: DUF697; cl12064
517418000280	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
517418000281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418000282	motif II; other site
517418000283	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
517418000284	tetramer interface [polypeptide binding]; other site
517418000285	dimer interface [polypeptide binding]; other site
517418000286	circadian clock protein KaiC; Reviewed; Region: PRK09302
517418000287	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418000288	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418000289	Walker A motif; other site
517418000290	Walker A motif; other site
517418000291	ATP binding site [chemical binding]; other site
517418000292	Walker B motif; other site
517418000293	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418000294	Walker A motif; other site
517418000295	ATP binding site [chemical binding]; other site
517418000296	Walker B motif; other site
517418000297	Lamin Tail Domain; Region: LTD; pfam00932
517418000298	Lamin Tail Domain; Region: LTD; pfam00932
517418000299	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418000300	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
517418000301	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
517418000302	hypothetical protein; Provisional; Region: PRK04164
517418000303	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
517418000304	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517418000305	Coenzyme A binding pocket [chemical binding]; other site
517418000306	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
517418000307	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517418000308	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418000309	FtsX-like permease family; Region: FtsX; cl15850
517418000310	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
517418000311	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
517418000312	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
517418000313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418000315	S-adenosylmethionine binding site [chemical binding]; other site
517418000316	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
517418000317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000318	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
517418000319	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
517418000320	CAAX protease self-immunity; Region: Abi; cl00558
517418000321	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
517418000322	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
517418000323	nucleotide binding pocket [chemical binding]; other site
517418000324	K-X-D-G motif; other site
517418000325	catalytic site [active]
517418000326	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
517418000327	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
517418000328	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
517418000329	Dimer interface [polypeptide binding]; other site
517418000330	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
517418000331	Competence protein; Region: Competence; cl00471
517418000332	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
517418000333	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
517418000334	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
517418000335	putative active site [active]
517418000336	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
517418000337	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
517418000338	MutS domain I; Region: MutS_I; pfam01624
517418000339	MutS domain II; Region: MutS_II; pfam05188
517418000340	MutS family domain IV; Region: MutS_IV; pfam05190
517418000341	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
517418000342	Walker A/P-loop; other site
517418000343	ATP binding site [chemical binding]; other site
517418000344	Q-loop/lid; other site
517418000345	ABC transporter signature motif; other site
517418000346	Walker B; other site
517418000347	D-loop; other site
517418000348	H-loop/switch region; other site
517418000349	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
517418000350	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
517418000351	malate dehydrogenase; Reviewed; Region: PRK06223
517418000352	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
517418000353	NAD(P) binding site [chemical binding]; other site
517418000354	dimer interface [polypeptide binding]; other site
517418000355	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517418000356	substrate binding site [chemical binding]; other site
517418000357	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
517418000358	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418000359	Zn binding site [ion binding]; other site
517418000360	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418000361	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
517418000362	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
517418000363	substrate binding site [chemical binding]; other site
517418000364	glutamase interaction surface [polypeptide binding]; other site
517418000365	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418000366	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
517418000367	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418000368	Radical SAM superfamily; Region: Radical_SAM; pfam04055
517418000369	FeS/SAM binding site; other site
517418000370	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
517418000371	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238
517418000372	putative iron binding site [ion binding]; other site
517418000373	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
517418000374	Zn binding site [ion binding]; other site
517418000375	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
517418000376	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
517418000377	putative dimer interface [polypeptide binding]; other site
517418000378	active site pocket [active]
517418000379	putative cataytic base [active]
517418000380	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
517418000381	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517418000382	catalytic core [active]
517418000383	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
517418000384	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
517418000385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418000386	FeS/SAM binding site; other site
517418000387	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418000388	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
517418000389	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418000390	cytidylate kinase; Provisional; Region: cmk; PRK00023
517418000391	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
517418000392	CMP-binding site; other site
517418000393	The sites determining sugar specificity; other site
517418000394	LytB protein; Region: LYTB; cl00507
517418000395	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
517418000396	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
517418000397	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
517418000398	RNA binding site [nucleotide binding]; other site
517418000399	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
517418000400	RNA binding site [nucleotide binding]; other site
517418000401	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
517418000402	RNA binding site [nucleotide binding]; other site
517418000403	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517418000404	RNA binding site [nucleotide binding]; other site
517418000405	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec5; cd05690
517418000406	RNA binding site [nucleotide binding]; other site
517418000407	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
517418000408	RNA binding site [nucleotide binding]; other site
517418000409	GTPase Era; Reviewed; Region: era; PRK00089
517418000410	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
517418000411	G1 box; other site
517418000412	GTP/Mg2+ binding site [chemical binding]; other site
517418000413	Switch I region; other site
517418000414	G2 box; other site
517418000415	Switch II region; other site
517418000416	G3 box; other site
517418000417	G4 box; other site
517418000418	G5 box; other site
517418000419	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
517418000420	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
517418000421	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
517418000422	EamA-like transporter family; Region: EamA; cl01037
517418000423	EamA-like transporter family; Region: EamA; cl01037
517418000424	Domain of unknown function (DUF202); Region: DUF202; cl09954
517418000425	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
517418000426	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517418000427	molybdopterin cofactor binding site; other site
517418000428	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
517418000429	putative molybdopterin cofactor binding site; other site
517418000430	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
517418000431	4Fe-4S binding domain; Region: Fer4; cl02805
517418000432	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
517418000433	Polysulphide reductase, NrfD; Region: NrfD; cl01295
517418000434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418000435	FeS/SAM binding site; other site
517418000436	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
517418000437	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
517418000438	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
517418000439	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418000440	FeS/SAM binding site; other site
517418000441	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
517418000442	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418000443	FeS/SAM binding site; other site
517418000444	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
517418000445	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
517418000446	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
517418000447	lipoyl attachment site [posttranslational modification]; other site
517418000448	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
517418000449	Cysteine-rich domain; Region: CCG; pfam02754
517418000450	Cysteine-rich domain; Region: CCG; pfam02754
517418000451	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
517418000452	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
517418000453	Ligand binding site [chemical binding]; other site
517418000454	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
517418000455	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
517418000456	Ligand binding site [chemical binding]; other site
517418000457	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
517418000458	Cysteine-rich domain; Region: CCG; pfam02754
517418000459	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418000460	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
517418000461	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
517418000462	Cysteine-rich domain; Region: CCG; pfam02754
517418000463	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
517418000464	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517418000465	catalytic residues [active]
517418000466	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
517418000467	lipoyl attachment site [posttranslational modification]; other site
517418000468	DsrE/DsrF-like family; Region: DrsE; cl00672
517418000469	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955
517418000470	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418000471	Walker A motif; other site
517418000472	ATP binding site [chemical binding]; other site
517418000473	Walker B motif; other site
517418000474	arginine finger; other site
517418000475	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
517418000476	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
517418000477	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
517418000478	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
517418000479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000480	PAS fold; Region: PAS_3; pfam08447
517418000481	putative active site [active]
517418000482	heme pocket [chemical binding]; other site
517418000483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418000484	PAS domain; Region: PAS_9; pfam13426
517418000485	PAS domain S-box; Region: sensory_box; TIGR00229
517418000486	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418000487	PAS domain S-box; Region: sensory_box; TIGR00229
517418000488	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418000489	PAS domain S-box; Region: sensory_box; TIGR00229
517418000490	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000491	putative active site [active]
517418000492	heme pocket [chemical binding]; other site
517418000493	PAS fold; Region: PAS_4; pfam08448
517418000494	PAS domain S-box; Region: sensory_box; TIGR00229
517418000495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000496	putative active site [active]
517418000497	heme pocket [chemical binding]; other site
517418000498	PAS domain S-box; Region: sensory_box; TIGR00229
517418000499	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418000500	PAS domain S-box; Region: sensory_box; TIGR00229
517418000501	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418000502	putative active site [active]
517418000503	heme pocket [chemical binding]; other site
517418000504	Histidine kinase; Region: HisKA_2; cl06527
517418000505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418000506	ATP binding site [chemical binding]; other site
517418000507	Mg2+ binding site [ion binding]; other site
517418000508	G-X-G motif; other site
517418000509	Response regulator receiver domain; Region: Response_reg; pfam00072
517418000510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418000511	active site
517418000512	phosphorylation site [posttranslational modification]
517418000513	intermolecular recognition site; other site
517418000514	dimerization interface [polypeptide binding]; other site
517418000515	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
517418000516	cyclase homology domain; Region: CHD; cd07302
517418000517	nucleotidyl binding site; other site
517418000518	metal binding site [ion binding]; metal-binding site
517418000519	dimer interface [polypeptide binding]; other site
517418000520	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
517418000521	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418000522	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
517418000523	Helix-turn-helix domains; Region: HTH; cl00088
517418000524	YceI-like domain; Region: YceI; cl01001
517418000525	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
517418000526	active site
517418000527	ADP/pyrophosphate binding site [chemical binding]; other site
517418000528	dimerization interface [polypeptide binding]; other site
517418000529	allosteric effector site; other site
517418000530	fructose-1,6-bisphosphate binding site; other site
517418000531	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
517418000532	RNA/DNA binding site [nucleotide binding]; other site
517418000533	RRM dimerization site [polypeptide binding]; other site
517418000534	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
517418000535	Protein export membrane protein; Region: SecD_SecF; cl14618
517418000536	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
517418000537	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
517418000538	Helix-turn-helix domains; Region: HTH; cl00088
517418000539	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
517418000540	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748
517418000541	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
517418000542	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517418000543	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418000544	homodimer interface [polypeptide binding]; other site
517418000545	catalytic residue [active]
517418000546	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
517418000547	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
517418000548	Ferritin-like domain; Region: Ferritin; pfam00210
517418000549	binuclear metal center [ion binding]; other site
517418000550	Rubredoxin [Energy production and conversion]; Region: COG1773
517418000551	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
517418000552	iron binding site [ion binding]; other site
517418000553	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
517418000554	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
517418000555	active site
517418000556	FMN binding site [chemical binding]; other site
517418000557	substrate binding site [chemical binding]; other site
517418000558	3Fe-4S cluster binding site [ion binding]; other site
517418000559	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
517418000560	Cysteine-rich domain; Region: CCG; pfam02754
517418000561	Cysteine-rich domain; Region: CCG; pfam02754
517418000562	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
517418000563	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
517418000564	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
517418000565	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
517418000566	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
517418000567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000568	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
517418000569	FOG: CBS domain [General function prediction only]; Region: COG0517
517418000570	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
517418000571	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
517418000572	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
517418000573	active site
517418000574	dimer interface [polypeptide binding]; other site
517418000575	metal binding site [ion binding]; metal-binding site
517418000576	shikimate kinase; Reviewed; Region: aroK; PRK00131
517418000577	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
517418000578	ADP binding site [chemical binding]; other site
517418000579	magnesium binding site [ion binding]; other site
517418000580	putative shikimate binding site; other site
517418000581	OsmC-like protein; Region: OsmC; cl00767
517418000582	FeoA domain; Region: FeoA; cl00838
517418000583	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
517418000584	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
517418000585	G1 box; other site
517418000586	GTP/Mg2+ binding site [chemical binding]; other site
517418000587	Switch I region; other site
517418000588	G2 box; other site
517418000589	G3 box; other site
517418000590	Switch II region; other site
517418000591	G4 box; other site
517418000592	G5 box; other site
517418000593	Nucleoside recognition; Region: Gate; cl00486
517418000594	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
517418000595	Nucleoside recognition; Region: Gate; cl00486
517418000596	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
517418000597	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
517418000598	TPP-binding site; other site
517418000599	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
517418000600	PYR/PP interface [polypeptide binding]; other site
517418000601	dimer interface [polypeptide binding]; other site
517418000602	TPP binding site [chemical binding]; other site
517418000603	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517418000604	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
517418000605	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
517418000606	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
517418000607	carboxyltransferase (CT) interaction site; other site
517418000608	biotinylation site [posttranslational modification]; other site
517418000609	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
517418000610	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
517418000611	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
517418000612	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
517418000613	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
517418000614	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
517418000615	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
517418000616	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
517418000617	DNA binding site [nucleotide binding]
517418000618	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
517418000619	active site
517418000620	HslU subunit interaction site [polypeptide binding]; other site
517418000621	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
517418000622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418000623	Walker A motif; other site
517418000624	ATP binding site [chemical binding]; other site
517418000625	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418000626	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
517418000627	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
517418000628	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
517418000629	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
517418000630	active site
517418000631	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
517418000632	trimer interface [polypeptide binding]; other site
517418000633	active site
517418000634	dimer interface [polypeptide binding]; other site
517418000635	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
517418000636	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
517418000637	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
517418000638	active site
517418000639	metal binding site [ion binding]; metal-binding site
517418000640	DNA binding site [nucleotide binding]
517418000641	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
517418000642	Predicted amidohydrolase [General function prediction only]; Region: COG0388
517418000643	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
517418000644	putative active site [active]
517418000645	catalytic triad [active]
517418000646	putative dimer interface [polypeptide binding]; other site
517418000647	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418000648	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
517418000649	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
517418000650	putative active site [active]
517418000651	putative metal binding site [ion binding]; other site
517418000652	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
517418000653	Protein of unknown function (DUF2492); Region: DUF2492; cl11278
517418000654	Sulfatase; Region: Sulfatase; cl10460
517418000655	diaminopimelate decarboxylase; Region: lysA; TIGR01048
517418000656	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
517418000657	active site
517418000658	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517418000659	substrate binding site [chemical binding]; other site
517418000660	catalytic residues [active]
517418000661	dimer interface [polypeptide binding]; other site
517418000662	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517418000663	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
517418000664	Sporulation related domain; Region: SPOR; cl10051
517418000665	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
517418000666	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
517418000667	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418000668	binding surface
517418000669	TPR repeat; Region: TPR_11; pfam13414
517418000670	TPR motif; other site
517418000671	TPR repeat; Region: TPR_11; pfam13414
517418000672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418000673	binding surface
517418000674	TPR repeat; Region: TPR_11; pfam13414
517418000675	TPR motif; other site
517418000676	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517418000677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418000678	binding surface
517418000679	TPR motif; other site
517418000680	TPR repeat; Region: TPR_11; pfam13414
517418000681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418000682	binding surface
517418000683	TPR motif; other site
517418000684	TPR repeat; Region: TPR_11; pfam13414
517418000685	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517418000686	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
517418000687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000688	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
517418000689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000690	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
517418000691	oligomerization interface [polypeptide binding]; other site
517418000692	active site
517418000693	metal binding site [ion binding]; metal-binding site
517418000694	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
517418000695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000696	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517418000697	ligand binding site [chemical binding]; other site
517418000698	FecR protein; Region: FecR; pfam04773
517418000699	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
517418000700	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
517418000701	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
517418000702	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
517418000703	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
517418000704	putative active site [active]
517418000705	catalytic triad [active]
517418000706	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
517418000707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418000708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418000709	putative substrate translocation pore; other site
517418000710	L-aspartate oxidase; Provisional; Region: PRK09077
517418000711	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000712	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
517418000713	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
517418000714	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
517418000715	G1 box; other site
517418000716	putative GEF interaction site [polypeptide binding]; other site
517418000717	GTP/Mg2+ binding site [chemical binding]; other site
517418000718	Switch I region; other site
517418000719	G2 box; other site
517418000720	G3 box; other site
517418000721	Switch II region; other site
517418000722	G4 box; other site
517418000723	G5 box; other site
517418000724	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
517418000725	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
517418000726	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
517418000727	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
517418000728	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
517418000729	Integral membrane protein DUF92; Region: DUF92; cl00793
517418000730	hydroxyglutarate oxidase; Provisional; Region: PRK11728
517418000731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000732	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
517418000733	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
517418000734	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
517418000735	catalytic residue [active]
517418000736	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
517418000737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000738	NAD(P) binding site [chemical binding]; other site
517418000739	active site
517418000740	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
517418000741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418000742	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
517418000743	L-serine binding site [chemical binding]; other site
517418000744	Protein of unknown function (DUF971); Region: DUF971; cl01414
517418000745	GAF domain; Region: GAF_2; pfam13185
517418000746	GAF domain; Region: GAF; cl15785
517418000747	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
517418000748	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
517418000749	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
517418000750	anti sigma factor interaction site; other site
517418000751	regulatory phosphorylation site [posttranslational modification]; other site
517418000752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
517418000753	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
517418000754	GAF domain; Region: GAF; cl15785
517418000755	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
517418000756	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
517418000757	Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123
517418000758	acetyl-CoA synthetase; Provisional; Region: PRK00174
517418000759	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
517418000760	AMP-binding enzyme; Region: AMP-binding; cl15778
517418000761	AMP-binding enzyme; Region: AMP-binding; cl15778
517418000762	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
517418000763	Family description; Region: VCBS; pfam13517
517418000764	Family description; Region: VCBS; pfam13517
517418000765	Family description; Region: VCBS; pfam13517
517418000766	Family description; Region: VCBS; pfam13517
517418000767	Family description; Region: VCBS; pfam13517
517418000768	Family description; Region: VCBS; pfam13517
517418000769	Family description; Region: VCBS; pfam13517
517418000770	Family description; Region: VCBS; pfam13517
517418000771	Family description; Region: VCBS; pfam13517
517418000772	Family description; Region: VCBS; pfam13517
517418000773	Family description; Region: VCBS; pfam13517
517418000774	Family description; Region: VCBS; pfam13517
517418000775	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418000776	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418000777	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
517418000778	histidinol dehydrogenase; Region: hisD; TIGR00069
517418000779	NAD binding site [chemical binding]; other site
517418000780	dimerization interface [polypeptide binding]; other site
517418000781	product binding site; other site
517418000782	substrate binding site [chemical binding]; other site
517418000783	zinc binding site [ion binding]; other site
517418000784	catalytic residues [active]
517418000785	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
517418000786	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
517418000787	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
517418000788	DsbD alpha interface [polypeptide binding]; other site
517418000789	catalytic residues [active]
517418000790	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
517418000791	putative catalytic residue [active]
517418000792	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
517418000793	active site
517418000794	catalytic residues [active]
517418000795	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418000796	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
517418000797	dimer interface [polypeptide binding]; other site
517418000798	putative tRNA-binding site [nucleotide binding]; other site
517418000799	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418000800	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418000801	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
517418000802	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
517418000803	HflX GTPase family; Region: HflX; cd01878
517418000804	G1 box; other site
517418000805	GTP/Mg2+ binding site [chemical binding]; other site
517418000806	Switch I region; other site
517418000807	G2 box; other site
517418000808	G3 box; other site
517418000809	Switch II region; other site
517418000810	G4 box; other site
517418000811	G5 box; other site
517418000812	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
517418000813	active site lid residues [active]
517418000814	substrate binding pocket [chemical binding]; other site
517418000815	catalytic residues [active]
517418000816	substrate-Mg2+ binding site; other site
517418000817	aspartate-rich region 1; other site
517418000818	aspartate-rich region 2; other site
517418000819	lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906
517418000820	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
517418000821	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
517418000822	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
517418000823	dimer interface [polypeptide binding]; other site
517418000824	putative anticodon binding site; other site
517418000825	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
517418000826	motif 1; other site
517418000827	active site
517418000828	motif 2; other site
517418000829	motif 3; other site
517418000830	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292
517418000831	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418000832	Ligand Binding Site [chemical binding]; other site
517418000833	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418000834	Ligand Binding Site [chemical binding]; other site
517418000835	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
517418000836	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418000837	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
517418000838	dimer interface [polypeptide binding]; other site
517418000839	substrate binding site [chemical binding]; other site
517418000840	metal binding sites [ion binding]; metal-binding site
517418000841	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
517418000842	active site
517418000843	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
517418000844	anti sigma factor interaction site; other site
517418000845	regulatory phosphorylation site [posttranslational modification]; other site
517418000846	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
517418000847	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
517418000848	Protein export membrane protein; Region: SecD_SecF; cl14618
517418000849	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
517418000850	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
517418000851	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13023
517418000852	Protein export membrane protein; Region: SecD_SecF; cl14618
517418000853	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
517418000854	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
517418000855	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
517418000856	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
517418000857	dimerization interface [polypeptide binding]; other site
517418000858	active site
517418000859	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
517418000860	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
517418000861	homooctamer interface [polypeptide binding]; other site
517418000862	active site
517418000863	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
517418000864	catalytic center binding site [active]
517418000865	ATP binding site [chemical binding]; other site
517418000866	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
517418000867	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
517418000868	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
517418000869	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
517418000870	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
517418000871	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
517418000872	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
517418000873	Baseplate J-like protein; Region: Baseplate_J; cl01294
517418000874	Phage tail tube protein FII; Region: Phage_tube; cl01390
517418000875	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
517418000876	Gp37 protein; Region: Gp37; pfam09646
517418000877	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
517418000878	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
517418000879	Mor transcription activator family; Region: Mor; cl02360
517418000880	Protein of unknown function (DUF1018); Region: DUF1018; cl01815
517418000881	AAA domain; Region: AAA_22; pfam13401
517418000882	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
517418000883	Integrase core domain; Region: rve; cl01316
517418000884	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
517418000885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
517418000886	non-specific DNA binding site [nucleotide binding]; other site
517418000887	salt bridge; other site
517418000888	sequence-specific DNA binding site [nucleotide binding]; other site
517418000889	LexA repressor; Provisional; Region: PRK12423
517418000890	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
517418000891	Catalytic site [active]
517418000892	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517418000893	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418000894	P loop; other site
517418000895	Nucleotide binding site [chemical binding]; other site
517418000896	DTAP/Switch II; other site
517418000897	Switch I; other site
517418000898	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
517418000899	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
517418000900	Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
517418000901	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517418000902	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418000903	P loop; other site
517418000904	Nucleotide binding site [chemical binding]; other site
517418000905	DTAP/Switch II; other site
517418000906	Switch I; other site
517418000907	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
517418000908	N-acetyl-D-glucosamine binding site [chemical binding]; other site
517418000909	catalytic residue [active]
517418000910	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
517418000911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
517418000912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418000913	binding surface
517418000914	TPR motif; other site
517418000915	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
517418000916	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
517418000917	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
517418000918	FAD binding pocket [chemical binding]; other site
517418000919	FAD binding motif [chemical binding]; other site
517418000920	phosphate binding motif [ion binding]; other site
517418000921	beta-alpha-beta structure motif; other site
517418000922	NAD binding pocket [chemical binding]; other site
517418000923	Iron coordination center [ion binding]; other site
517418000924	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418000925	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418000926	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517418000927	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418000928	Clp protease ATP binding subunit; Region: clpC; CHL00095
517418000929	Clp amino terminal domain; Region: Clp_N; pfam02861
517418000930	Clp amino terminal domain; Region: Clp_N; pfam02861
517418000931	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418000932	Walker A motif; other site
517418000933	ATP binding site [chemical binding]; other site
517418000934	Walker B motif; other site
517418000935	arginine finger; other site
517418000936	UvrB/uvrC motif; Region: UVR; pfam02151
517418000937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418000938	Walker A motif; other site
517418000939	ATP binding site [chemical binding]; other site
517418000940	Walker B motif; other site
517418000941	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
517418000942	PSP1 C-terminal conserved region; Region: PSP1; cl00770
517418000943	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
517418000944	putative hydrophobic ligand binding site [chemical binding]; other site
517418000945	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
517418000946	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
517418000947	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418000948	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
517418000949	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
517418000950	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
517418000951	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
517418000952	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
517418000953	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
517418000954	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
517418000955	DEAD-like helicases superfamily; Region: DEXDc; smart00487
517418000956	ATP binding site [chemical binding]; other site
517418000957	Mg++ binding site [ion binding]; other site
517418000958	motif III; other site
517418000959	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418000960	nucleotide binding region [chemical binding]; other site
517418000961	ATP-binding site [chemical binding]; other site
517418000962	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
517418000963	SurA N-terminal domain; Region: SurA_N_3; cl07813
517418000964	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418000965	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418000966	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418000967	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418000968	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418000969	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
517418000970	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
517418000971	Walker A/P-loop; other site
517418000972	ATP binding site [chemical binding]; other site
517418000973	Q-loop/lid; other site
517418000974	ABC transporter signature motif; other site
517418000975	Walker B; other site
517418000976	D-loop; other site
517418000977	H-loop/switch region; other site
517418000978	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
517418000979	NeuB family; Region: NeuB; cl00496
517418000980	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
517418000981	ABC-2 type transporter; Region: ABC2_membrane; cl11417
517418000982	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
517418000983	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
517418000984	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
517418000985	Walker A/P-loop; other site
517418000986	ATP binding site [chemical binding]; other site
517418000987	Q-loop/lid; other site
517418000988	ABC transporter signature motif; other site
517418000989	Walker B; other site
517418000990	D-loop; other site
517418000991	H-loop/switch region; other site
517418000992	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
517418000993	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
517418000994	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
517418000995	NAD(P) binding site [chemical binding]; other site
517418000996	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
517418000997	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
517418000998	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
517418000999	substrate binding pocket [chemical binding]; other site
517418001000	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
517418001001	B12 binding site [chemical binding]; other site
517418001002	cobalt ligand [ion binding]; other site
517418001003	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
517418001004	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
517418001005	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
517418001006	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
517418001007	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
517418001008	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
517418001009	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418001010	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
517418001011	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
517418001012	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
517418001013	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418001014	Walker A motif; other site
517418001015	ATP binding site [chemical binding]; other site
517418001016	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
517418001017	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
517418001018	homodimer interface [polypeptide binding]; other site
517418001019	substrate-cofactor binding pocket; other site
517418001020	catalytic residue [active]
517418001021	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
517418001022	putative acyl-acceptor binding pocket; other site
517418001023	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
517418001024	active site residue [active]
517418001025	Low molecular weight phosphatase family; Region: LMWPc; cd00115
517418001026	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
517418001027	active site
517418001028	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
517418001029	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
517418001030	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418001031	S-adenosylmethionine binding site [chemical binding]; other site
517418001032	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
517418001033	Protein of unknown function (DUF525); Region: DUF525; cl01119
517418001034	Protein of unknown function (DUF3808); Region: DUF3808; pfam10300
517418001035	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001036	binding surface
517418001037	TPR motif; other site
517418001038	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517418001039	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517418001040	putative active site [active]
517418001041	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
517418001042	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
517418001043	putative active site [active]
517418001044	putative metal binding site [ion binding]; other site
517418001045	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
517418001046	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418001047	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
517418001048	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
517418001049	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
517418001050	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
517418001051	FAD binding pocket [chemical binding]; other site
517418001052	FAD binding motif [chemical binding]; other site
517418001053	phosphate binding motif [ion binding]; other site
517418001054	beta-alpha-beta structure motif; other site
517418001055	NAD binding pocket [chemical binding]; other site
517418001056	Iron coordination center [ion binding]; other site
517418001057	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
517418001058	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
517418001059	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
517418001060	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418001061	protein binding site [polypeptide binding]; other site
517418001062	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418001063	protein binding site [polypeptide binding]; other site
517418001064	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
517418001065	Recombination protein O N terminal; Region: RecO_N; cl15812
517418001066	Recombination protein O C terminal; Region: RecO_C; pfam02565
517418001067	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
517418001068	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
517418001069	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
517418001070	NAD(P) binding site [chemical binding]; other site
517418001071	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
517418001072	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
517418001073	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418001074	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
517418001075	Probable Catalytic site; other site
517418001076	Surface antigen; Region: Bac_surface_Ag; cl03097
517418001077	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418001078	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
517418001079	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
517418001080	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
517418001081	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
517418001082	Ligand binding site; other site
517418001083	Putative Catalytic site; other site
517418001084	DXD motif; other site
517418001085	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
517418001086	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
517418001087	active site
517418001088	purine riboside binding site [chemical binding]; other site
517418001089	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001091	TPR motif; other site
517418001092	binding surface
517418001093	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001094	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418001096	binding surface
517418001097	TPR motif; other site
517418001098	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418001099	metal binding site [ion binding]; metal-binding site
517418001100	active site
517418001101	I-site; other site
517418001102	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
517418001103	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
517418001104	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
517418001105	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
517418001106	active site
517418001107	dimer interface [polypeptide binding]; other site
517418001108	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
517418001109	Ligand Binding Site [chemical binding]; other site
517418001110	Molecular Tunnel; other site
517418001111	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
517418001112	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
517418001113	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817
517418001114	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759
517418001115	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
517418001116	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418001117	Bacterial sugar transferase; Region: Bac_transf; cl00939
517418001118	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517418001119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418001120	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
517418001121	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
517418001122	putative trimer interface [polypeptide binding]; other site
517418001123	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
517418001124	putative trimer interface [polypeptide binding]; other site
517418001125	putative CoA binding site [chemical binding]; other site
517418001126	Phosphopantetheine attachment site; Region: PP-binding; cl09936
517418001127	AMP-binding enzyme; Region: AMP-binding; cl15778
517418001128	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
517418001129	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
517418001130	classical (c) SDRs; Region: SDR_c; cd05233
517418001131	NAD(P) binding site [chemical binding]; other site
517418001132	active site
517418001133	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001134	binding surface
517418001135	TPR motif; other site
517418001136	TPR repeat; Region: TPR_11; pfam13414
517418001137	TPR repeat; Region: TPR_11; pfam13414
517418001138	TPR repeat; Region: TPR_11; pfam13414
517418001139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001140	binding surface
517418001141	TPR motif; other site
517418001142	TPR repeat; Region: TPR_11; pfam13414
517418001143	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001144	binding surface
517418001145	TPR motif; other site
517418001146	TPR repeat; Region: TPR_11; pfam13414
517418001147	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
517418001148	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517418001149	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
517418001150	structural tetrad; other site
517418001151	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
517418001152	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
517418001153	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
517418001154	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
517418001155	Domain interface; other site
517418001156	Peptide binding site; other site
517418001157	Active site tetrad [active]
517418001158	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
517418001159	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
517418001160	substrate binding pocket [chemical binding]; other site
517418001161	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
517418001162	membrane-bound complex binding site; other site
517418001163	hinge residues; other site
517418001164	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
517418001165	N-acetyl-D-glucosamine binding site [chemical binding]; other site
517418001166	catalytic residue [active]
517418001167	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
517418001168	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
517418001169	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517418001170	DXD motif; other site
517418001171	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
517418001172	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
517418001173	Probable Catalytic site; other site
517418001174	metal-binding site
517418001175	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
517418001176	CHAT domain; Region: CHAT; pfam12770
517418001177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418001178	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001179	binding surface
517418001180	TPR motif; other site
517418001181	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001183	binding surface
517418001184	TPR motif; other site
517418001185	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001186	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001187	binding surface
517418001188	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001189	TPR motif; other site
517418001190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001191	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
517418001192	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
517418001193	trimer interface [polypeptide binding]; other site
517418001194	active site
517418001195	substrate binding site [chemical binding]; other site
517418001196	CoA binding site [chemical binding]; other site
517418001197	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
517418001198	putative homodimer interface [polypeptide binding]; other site
517418001199	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
517418001200	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418001201	active site
517418001202	MatE; Region: MatE; cl10513
517418001203	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418001204	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
517418001205	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418001206	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
517418001207	O-Antigen ligase; Region: Wzy_C; cl04850
517418001208	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517418001209	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
517418001210	DXD motif; other site
517418001211	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
517418001212	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
517418001213	Outer membrane efflux protein; Region: OEP; pfam02321
517418001214	Response regulator receiver domain; Region: Response_reg; pfam00072
517418001215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
517418001216	active site
517418001217	phosphorylation site [posttranslational modification]
517418001218	intermolecular recognition site; other site
517418001219	dimerization interface [polypeptide binding]; other site
517418001220	Bacterial sugar transferase; Region: Bac_transf; cl00939
517418001221	Response regulator receiver domain; Region: Response_reg; pfam00072
517418001222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001223	active site
517418001224	phosphorylation site [posttranslational modification]
517418001225	intermolecular recognition site; other site
517418001226	dimerization interface [polypeptide binding]; other site
517418001227	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
517418001228	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
517418001229	active site
517418001230	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517418001231	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418001232	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517418001233	putative active site [active]
517418001234	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
517418001235	heme-binding site [chemical binding]; other site
517418001236	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
517418001237	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418001238	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
517418001239	G1 box; other site
517418001240	GTP/Mg2+ binding site [chemical binding]; other site
517418001241	G2 box; other site
517418001242	Switch I region; other site
517418001243	G3 box; other site
517418001244	Switch II region; other site
517418001245	G4 box; other site
517418001246	G5 box; other site
517418001247	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418001248	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
517418001249	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418001250	FtsX-like permease family; Region: FtsX; cl15850
517418001251	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
517418001252	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
517418001253	homotetramer interface [polypeptide binding]; other site
517418001254	FMN binding site [chemical binding]; other site
517418001255	homodimer contacts [polypeptide binding]; other site
517418001256	putative active site [active]
517418001257	putative substrate binding site [chemical binding]; other site
517418001258	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
517418001259	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
517418001260	substrate binding pocket [chemical binding]; other site
517418001261	chain length determination region; other site
517418001262	substrate-Mg2+ binding site; other site
517418001263	catalytic residues [active]
517418001264	aspartate-rich region 1; other site
517418001265	active site lid residues [active]
517418001266	aspartate-rich region 2; other site
517418001267	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
517418001268	Nitrogen regulatory protein P-II; Region: P-II; cl00412
517418001269	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517418001270	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
517418001271	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
517418001272	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
517418001273	HEAT repeats; Region: HEAT_2; pfam13646
517418001274	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
517418001275	active site
517418001276	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
517418001277	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
517418001278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418001279	dimer interface [polypeptide binding]; other site
517418001280	phosphorylation site [posttranslational modification]
517418001281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418001282	ATP binding site [chemical binding]; other site
517418001283	Mg2+ binding site [ion binding]; other site
517418001284	G-X-G motif; other site
517418001285	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418001286	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418001287	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
517418001288	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418001289	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418001290	Outer membrane efflux protein; Region: OEP; pfam02321
517418001291	Outer membrane efflux protein; Region: OEP; pfam02321
517418001292	HerA helicase [Replication, recombination, and repair]; Region: COG0433
517418001293	Domain of unknown function DUF87; Region: DUF87; pfam01935
517418001294	Membrane protein of unknown function; Region: DUF360; cl00850
517418001295	Uncharacterized conserved protein [Function unknown]; Region: COG5316
517418001296	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
517418001297	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
517418001298	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
517418001299	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
517418001300	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
517418001301	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418001302	Walker A motif; other site
517418001303	ATP binding site [chemical binding]; other site
517418001304	Walker B motif; other site
517418001305	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
517418001306	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
517418001307	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
517418001308	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
517418001309	tetramer interface [polypeptide binding]; other site
517418001310	TPP-binding site [chemical binding]; other site
517418001311	heterodimer interface [polypeptide binding]; other site
517418001312	phosphorylation loop region [posttranslational modification]
517418001313	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
517418001314	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
517418001315	alpha subunit interface [polypeptide binding]; other site
517418001316	TPP binding site [chemical binding]; other site
517418001317	heterodimer interface [polypeptide binding]; other site
517418001318	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517418001319	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
517418001320	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517418001321	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517418001322	putative active site [active]
517418001323	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418001324	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
517418001325	DNA topoisomerase I; Validated; Region: PRK06599
517418001326	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
517418001327	active site
517418001328	interdomain interaction site; other site
517418001329	putative metal-binding site [ion binding]; other site
517418001330	nucleotide binding site [chemical binding]; other site
517418001331	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
517418001332	domain I; other site
517418001333	DNA binding groove [nucleotide binding]
517418001334	phosphate binding site [ion binding]; other site
517418001335	domain II; other site
517418001336	domain III; other site
517418001337	nucleotide binding site [chemical binding]; other site
517418001338	catalytic site [active]
517418001339	domain IV; other site
517418001340	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
517418001341	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
517418001342	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
517418001343	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418001344	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
517418001345	Cobalt transport protein; Region: CbiQ; cl00463
517418001346	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
517418001347	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
517418001348	Walker A/P-loop; other site
517418001349	ATP binding site [chemical binding]; other site
517418001350	Q-loop/lid; other site
517418001351	ABC transporter signature motif; other site
517418001352	Walker B; other site
517418001353	D-loop; other site
517418001354	H-loop/switch region; other site
517418001355	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
517418001356	Walker A/P-loop; other site
517418001357	ATP binding site [chemical binding]; other site
517418001358	Q-loop/lid; other site
517418001359	ABC transporter signature motif; other site
517418001360	Walker B; other site
517418001361	D-loop; other site
517418001362	H-loop/switch region; other site
517418001363	AAA domain; Region: AAA_22; pfam13401
517418001364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418001365	Walker A motif; other site
517418001366	ATP binding site [chemical binding]; other site
517418001367	Walker B motif; other site
517418001368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001369	TPR motif; other site
517418001370	binding surface
517418001371	TPR repeat; Region: TPR_11; pfam13414
517418001372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001373	binding surface
517418001374	TPR motif; other site
517418001375	TPR repeat; Region: TPR_11; pfam13414
517418001376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001377	binding surface
517418001378	TPR motif; other site
517418001379	TPR repeat; Region: TPR_11; pfam13414
517418001380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001381	binding surface
517418001382	TPR motif; other site
517418001383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001384	binding surface
517418001385	TPR motif; other site
517418001386	TPR repeat; Region: TPR_11; pfam13414
517418001387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418001388	S-adenosylmethionine binding site [chemical binding]; other site
517418001389	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418001390	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
517418001391	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418001392	N-terminal plug; other site
517418001393	ligand-binding site [chemical binding]; other site
517418001394	Peptidase family M48; Region: Peptidase_M48; cl12018
517418001395	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
517418001396	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
517418001397	dimerization interface 3.5A [polypeptide binding]; other site
517418001398	active site
517418001399	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
517418001400	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
517418001401	homodimer interface [polypeptide binding]; other site
517418001402	active site
517418001403	catalytic site [active]
517418001404	maltose binding site 2 [chemical binding]; other site
517418001405	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
517418001406	substrate binding site [chemical binding]; other site
517418001407	ATP binding site [chemical binding]; other site
517418001408	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517418001409	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
517418001410	NAD binding site [chemical binding]; other site
517418001411	putative substrate binding site 2 [chemical binding]; other site
517418001412	putative substrate binding site 1 [chemical binding]; other site
517418001413	active site
517418001414	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174
517418001415	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
517418001416	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
517418001417	homodimer interface [polypeptide binding]; other site
517418001418	NADP binding site [chemical binding]; other site
517418001419	substrate binding site [chemical binding]; other site
517418001420	4Fe-4S binding domain; Region: Fer4; cl02805
517418001421	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
517418001422	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
517418001423	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
517418001424	DNA polymerase III, delta subunit; Region: holA; TIGR01128
517418001425	CHAD domain; Region: CHAD; cl10506
517418001426	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
517418001427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517418001428	Coenzyme A binding pocket [chemical binding]; other site
517418001429	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
517418001430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418001431	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
517418001432	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
517418001433	putative Iron-sulfur protein interface [polypeptide binding]; other site
517418001434	putative proximal heme binding site [chemical binding]; other site
517418001435	putative SdhC-like subunit interface [polypeptide binding]; other site
517418001436	putative distal heme binding site [chemical binding]; other site
517418001437	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
517418001438	putative Iron-sulfur protein interface [polypeptide binding]; other site
517418001439	putative proximal heme binding site [chemical binding]; other site
517418001440	putative SdhD-like interface [polypeptide binding]; other site
517418001441	putative distal heme binding site [chemical binding]; other site
517418001442	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418001444	binding surface
517418001445	TPR motif; other site
517418001446	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001447	acetyl-CoA synthetase; Provisional; Region: PRK00174
517418001448	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
517418001449	AMP-binding enzyme; Region: AMP-binding; cl15778
517418001450	AMP-binding enzyme; Region: AMP-binding; cl15778
517418001451	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
517418001452	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
517418001453	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
517418001454	Substrate-binding site [chemical binding]; other site
517418001455	Substrate specificity [chemical binding]; other site
517418001456	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
517418001457	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
517418001458	Sm1 motif; other site
517418001459	Hfq - Hfq interaction site; other site
517418001460	D3 - B interaction site; other site
517418001461	D1 - D2 interaction site; other site
517418001462	RNA binding pocket [nucleotide binding]; other site
517418001463	Sm2 motif; other site
517418001464	NusA N-terminal domain; Region: NusA_N; pfam08529
517418001465	transcription termination factor NusA; Region: NusA; TIGR01953
517418001466	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517418001467	RNA binding site [nucleotide binding]; other site
517418001468	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
517418001469	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
517418001470	G-X-X-G motif; other site
517418001471	translation initiation factor IF-2; Region: IF-2; TIGR00487
517418001472	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
517418001473	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
517418001474	G1 box; other site
517418001475	putative GEF interaction site [polypeptide binding]; other site
517418001476	GTP/Mg2+ binding site [chemical binding]; other site
517418001477	Switch I region; other site
517418001478	G2 box; other site
517418001479	G3 box; other site
517418001480	Switch II region; other site
517418001481	G4 box; other site
517418001482	G5 box; other site
517418001483	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
517418001484	Translation-initiation factor 2; Region: IF-2; pfam11987
517418001485	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
517418001486	Ribosome-binding factor A; Region: RBFA; cl00542
517418001487	Aerotolerance regulator N-terminal; Region: BatA; cl06567
517418001488	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
517418001489	metal ion-dependent adhesion site (MIDAS); other site
517418001490	OPT oligopeptide transporter protein; Region: OPT; cl14607
517418001491	oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728
517418001492	Response regulator receiver domain; Region: Response_reg; pfam00072
517418001493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001494	active site
517418001495	phosphorylation site [posttranslational modification]
517418001496	intermolecular recognition site; other site
517418001497	dimerization interface [polypeptide binding]; other site
517418001498	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
517418001499	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
517418001500	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
517418001501	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
517418001502	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
517418001503	intrachain domain interface; other site
517418001504	interchain domain interface [polypeptide binding]; other site
517418001505	heme bH binding site [chemical binding]; other site
517418001506	Qi binding site; other site
517418001507	heme bL binding site [chemical binding]; other site
517418001508	Qo binding site; other site
517418001509	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
517418001510	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
517418001511	iron-sulfur cluster [ion binding]; other site
517418001512	[2Fe-2S] cluster binding site [ion binding]; other site
517418001513	DinB superfamily; Region: DinB_2; pfam12867
517418001514	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
517418001515	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
517418001516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001517	active site
517418001518	phosphorylation site [posttranslational modification]
517418001519	intermolecular recognition site; other site
517418001520	dimerization interface [polypeptide binding]; other site
517418001521	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
517418001522	DNA binding site [nucleotide binding]
517418001523	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
517418001524	dimer interface [polypeptide binding]; other site
517418001525	catalytic triad [active]
517418001526	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
517418001527	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
517418001528	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
517418001529	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
517418001530	alpha subunit interaction interface [polypeptide binding]; other site
517418001531	Walker A motif; other site
517418001532	ATP binding site [chemical binding]; other site
517418001533	Walker B motif; other site
517418001534	inhibitor binding site; inhibition site
517418001535	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
517418001536	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
517418001537	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418001538	FeS/SAM binding site; other site
517418001539	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
517418001540	putative ligand binding pocket/active site [active]
517418001541	putative metal binding site [ion binding]; other site
517418001542	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418001543	structural tetrad; other site
517418001544	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
517418001545	active site
517418001546	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
517418001547	GTP cyclohydrolase I; Provisional; Region: PLN03044
517418001548	active site
517418001549	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
517418001550	putative active site [active]
517418001551	putative metal binding site [ion binding]; other site
517418001552	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
517418001553	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
517418001554	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418001555	histidine kinase; Provisional; Region: PRK13557
517418001556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418001557	putative active site [active]
517418001558	heme pocket [chemical binding]; other site
517418001559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418001560	dimer interface [polypeptide binding]; other site
517418001561	phosphorylation site [posttranslational modification]
517418001562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418001563	ATP binding site [chemical binding]; other site
517418001564	Mg2+ binding site [ion binding]; other site
517418001565	G-X-G motif; other site
517418001566	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001567	active site
517418001568	phosphorylation site [posttranslational modification]
517418001569	intermolecular recognition site; other site
517418001570	dimerization interface [polypeptide binding]; other site
517418001571	GAF domain; Region: GAF_2; pfam13185
517418001572	PAS fold; Region: PAS_4; pfam08448
517418001573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418001574	PAS fold; Region: PAS_3; pfam08447
517418001575	putative active site [active]
517418001576	heme pocket [chemical binding]; other site
517418001577	PAS domain S-box; Region: sensory_box; TIGR00229
517418001578	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418001579	putative active site [active]
517418001580	heme pocket [chemical binding]; other site
517418001581	PAS domain S-box; Region: sensory_box; TIGR00229
517418001582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418001583	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
517418001584	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517418001585	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192
517418001586	SurA N-terminal domain; Region: SurA_N_3; cl07813
517418001587	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418001588	PPIC-type PPIASE domain; Region: Rotamase; cl08278
517418001589	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
517418001590	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
517418001591	active site
517418001592	dimerization interface [polypeptide binding]; other site
517418001593	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
517418001594	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
517418001595	ligand binding site [chemical binding]; other site
517418001596	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
517418001597	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418001598	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
517418001599	active site
517418001600	catalytic site [active]
517418001601	substrate binding site [chemical binding]; other site
517418001602	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
517418001603	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
517418001604	CHASE2 domain; Region: CHASE2; cl01732
517418001605	cyclase homology domain; Region: CHD; cd07302
517418001606	nucleotidyl binding site; other site
517418001607	metal binding site [ion binding]; metal-binding site
517418001608	dimer interface [polypeptide binding]; other site
517418001609	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
517418001610	SelR domain; Region: SelR; pfam01641
517418001611	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418001612	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517418001613	FtsX-like permease family; Region: FtsX; cl15850
517418001614	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418001615	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418001616	Walker A/P-loop; other site
517418001617	ATP binding site [chemical binding]; other site
517418001618	Q-loop/lid; other site
517418001619	ABC transporter signature motif; other site
517418001620	Walker B; other site
517418001621	D-loop; other site
517418001622	H-loop/switch region; other site
517418001623	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
517418001624	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418001625	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418001626	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
517418001627	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
517418001628	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
517418001629	synthetase active site [active]
517418001630	NTP binding site [chemical binding]; other site
517418001631	metal binding site [ion binding]; metal-binding site
517418001632	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
517418001633	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
517418001634	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
517418001635	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
517418001636	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
517418001637	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
517418001638	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
517418001639	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
517418001640	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
517418001641	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
517418001642	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418001643	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
517418001644	Acetokinase family; Region: Acetate_kinase; cl01029
517418001645	propionate/acetate kinase; Provisional; Region: PRK12379
517418001646	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517418001647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517418001648	active site
517418001649	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418001650	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
517418001651	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
517418001652	active site
517418001653	catalytic site [active]
517418001654	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
517418001655	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
517418001656	Lipopolysaccharide-assembly; Region: LptE; cl01125
517418001657	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
517418001658	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
517418001659	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
517418001660	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
517418001661	active site
517418001662	HIGH motif; other site
517418001663	dimer interface [polypeptide binding]; other site
517418001664	KMSKS motif; other site
517418001665	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
517418001666	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
517418001667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418001668	motif II; other site
517418001669	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
517418001670	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
517418001671	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
517418001672	active site
517418001673	HIGH motif; other site
517418001674	KMSK motif region; other site
517418001675	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
517418001676	tRNA binding surface [nucleotide binding]; other site
517418001677	anticodon binding site; other site
517418001678	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
517418001679	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418001680	Zn2+ binding site [ion binding]; other site
517418001681	Mg2+ binding site [ion binding]; other site
517418001682	YtxH-like protein; Region: YtxH; cl02079
517418001683	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517418001684	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
517418001685	classical (c) SDRs; Region: SDR_c; cd05233
517418001686	NAD(P) binding site [chemical binding]; other site
517418001687	active site
517418001688	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
517418001689	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
517418001690	active site
517418001691	Substrate binding site; other site
517418001692	Mg++ binding site; other site
517418001693	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
517418001694	putative trimer interface [polypeptide binding]; other site
517418001695	putative CoA binding site [chemical binding]; other site
517418001696	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
517418001697	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
517418001698	active site
517418001699	substrate binding site [chemical binding]; other site
517418001700	metal binding site [ion binding]; metal-binding site
517418001701	RecX family; Region: RecX; cl00936
517418001702	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
517418001703	putative nucleotide binding site [chemical binding]; other site
517418001704	uridine monophosphate binding site [chemical binding]; other site
517418001705	homohexameric interface [polypeptide binding]; other site
517418001706	elongation factor Ts; Provisional; Region: tsf; PRK09377
517418001707	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
517418001708	Elongation factor TS; Region: EF_TS; pfam00889
517418001709	Elongation factor TS; Region: EF_TS; pfam00889
517418001710	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
517418001711	rRNA interaction site [nucleotide binding]; other site
517418001712	S8 interaction site; other site
517418001713	putative laminin-1 binding site; other site
517418001714	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
517418001715	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
517418001716	23S rRNA interface [nucleotide binding]; other site
517418001717	L3 interface [polypeptide binding]; other site
517418001718	rod shape-determining protein MreB; Provisional; Region: PRK13930
517418001719	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
517418001720	ATP binding site [chemical binding]; other site
517418001721	gelsolin binding site; other site
517418001722	profilin binding site; other site
517418001723	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
517418001724	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
517418001725	O-Antigen ligase; Region: Wzy_C; cl04850
517418001726	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418001727	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418001728	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
517418001729	substrate binding site [chemical binding]; other site
517418001730	dimer interface [polypeptide binding]; other site
517418001731	catalytic triad [active]
517418001732	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
517418001733	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
517418001734	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
517418001735	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
517418001736	substrate binding site [chemical binding]; other site
517418001737	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
517418001738	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
517418001739	FAD binding site [chemical binding]; other site
517418001740	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
517418001741	active site
517418001742	catalytic site [active]
517418001743	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
517418001744	active site
517418001745	dimer interface [polypeptide binding]; other site
517418001746	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
517418001747	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
517418001748	glutaminase active site [active]
517418001749	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
517418001750	dimer interface [polypeptide binding]; other site
517418001751	active site
517418001752	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
517418001753	dimer interface [polypeptide binding]; other site
517418001754	active site
517418001755	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
517418001756	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418001757	active site
517418001758	Response regulator receiver domain; Region: Response_reg; pfam00072
517418001759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001760	active site
517418001761	phosphorylation site [posttranslational modification]
517418001762	intermolecular recognition site; other site
517418001763	dimerization interface [polypeptide binding]; other site
517418001764	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418001765	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
517418001766	G1 box; other site
517418001767	GTP/Mg2+ binding site [chemical binding]; other site
517418001768	G2 box; other site
517418001769	Switch I region; other site
517418001770	G3 box; other site
517418001771	Switch II region; other site
517418001772	G4 box; other site
517418001773	G5 box; other site
517418001774	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
517418001775	metal-binding site [ion binding]
517418001776	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
517418001777	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
517418001778	metal-binding site [ion binding]
517418001779	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
517418001780	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
517418001781	CrcB-like protein; Region: CRCB; cl09114
517418001782	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
517418001783	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
517418001784	putative RNA binding site [nucleotide binding]; other site
517418001785	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517418001786	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
517418001787	active site
517418001788	metal binding site [ion binding]; metal-binding site
517418001789	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
517418001790	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517418001791	minor groove reading motif; other site
517418001792	helix-hairpin-helix signature motif; other site
517418001793	substrate binding pocket [chemical binding]; other site
517418001794	active site
517418001795	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
517418001796	Protein of unknown function (DUF520); Region: DUF520; cl00723
517418001797	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
517418001798	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
517418001799	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
517418001800	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
517418001801	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
517418001802	putative active site [active]
517418001803	seryl-tRNA synthetase; Provisional; Region: PRK05431
517418001804	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
517418001805	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
517418001806	dimer interface [polypeptide binding]; other site
517418001807	active site
517418001808	motif 1; other site
517418001809	motif 2; other site
517418001810	motif 3; other site
517418001811	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
517418001812	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418001813	GatB domain; Region: GatB_Yqey; cl11497
517418001814	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
517418001815	homotrimer interaction site [polypeptide binding]; other site
517418001816	zinc binding site [ion binding]; other site
517418001817	CDP-binding sites; other site
517418001818	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
517418001819	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418001820	Walker A/P-loop; other site
517418001821	ATP binding site [chemical binding]; other site
517418001822	Q-loop/lid; other site
517418001823	ABC transporter signature motif; other site
517418001824	Walker B; other site
517418001825	D-loop; other site
517418001826	H-loop/switch region; other site
517418001827	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
517418001828	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
517418001829	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
517418001830	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
517418001831	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517418001832	inhibitor-cofactor binding pocket; inhibition site
517418001833	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418001834	catalytic residue [active]
517418001835	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418001836	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
517418001837	NeuB family; Region: NeuB; cl00496
517418001838	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
517418001839	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
517418001840	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
517418001841	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
517418001842	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
517418001843	active site
517418001844	catalytic site [active]
517418001845	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
517418001846	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
517418001847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517418001848	active site
517418001849	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418001850	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517418001851	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418001852	P loop; other site
517418001853	Nucleotide binding site [chemical binding]; other site
517418001854	DTAP/Switch II; other site
517418001855	Switch I; other site
517418001856	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
517418001857	MPT binding site; other site
517418001858	trimer interface [polypeptide binding]; other site
517418001859	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
517418001860	ATP phosphoribosyltransferase; Region: HisG; cl15266
517418001861	HisG, C-terminal domain; Region: HisG_C; cl06867
517418001862	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
517418001863	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517418001864	putative active site [active]
517418001865	putative metal binding site [ion binding]; other site
517418001866	UbiA prenyltransferase family; Region: UbiA; cl00337
517418001867	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
517418001868	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
517418001869	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418001870	FeS/SAM binding site; other site
517418001871	TRAM domain; Region: TRAM; cl01282
517418001872	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418001873	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517418001874	FtsX-like permease family; Region: FtsX; cl15850
517418001875	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418001876	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517418001877	FtsX-like permease family; Region: FtsX; cl15850
517418001878	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418001879	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418001880	Walker A/P-loop; other site
517418001881	ATP binding site [chemical binding]; other site
517418001882	Q-loop/lid; other site
517418001883	ABC transporter signature motif; other site
517418001884	Walker B; other site
517418001885	D-loop; other site
517418001886	H-loop/switch region; other site
517418001887	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
517418001888	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
517418001889	active site
517418001890	substrate binding site [chemical binding]; other site
517418001891	metal binding site [ion binding]; metal-binding site
517418001892	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
517418001893	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
517418001894	Ligand binding site; other site
517418001895	Putative Catalytic site; other site
517418001896	DXD motif; other site
517418001897	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
517418001898	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
517418001899	dimer interface [polypeptide binding]; other site
517418001900	substrate binding site [chemical binding]; other site
517418001901	metal binding site [ion binding]; metal-binding site
517418001902	transcription termination factor Rho; Provisional; Region: rho; PRK09376
517418001903	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
517418001904	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
517418001905	RNA binding site [nucleotide binding]; other site
517418001906	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
517418001907	multimer interface [polypeptide binding]; other site
517418001908	Walker A motif; other site
517418001909	ATP binding site [chemical binding]; other site
517418001910	Walker B motif; other site
517418001911	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
517418001912	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517418001913	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
517418001914	RuvA N terminal domain; Region: RuvA_N; pfam01330
517418001915	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
517418001916	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
517418001917	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
517418001918	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
517418001919	motif 1; other site
517418001920	active site
517418001921	motif 2; other site
517418001922	motif 3; other site
517418001923	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
517418001924	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001926	binding surface
517418001927	TPR motif; other site
517418001928	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001929	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001931	binding surface
517418001932	TPR motif; other site
517418001933	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001934	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001935	binding surface
517418001936	TPR motif; other site
517418001937	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001938	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001939	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418001940	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
517418001941	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
517418001942	active site
517418001943	HIGH motif; other site
517418001944	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
517418001945	KMSKS motif; other site
517418001946	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
517418001947	tRNA binding surface [nucleotide binding]; other site
517418001948	anticodon binding site; other site
517418001949	Protein of unknown function (DUF429); Region: DUF429; cl12046
517418001950	NADH dehydrogenase; Region: NADHdh; cl00469
517418001951	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
517418001952	octamerization interface [polypeptide binding]; other site
517418001953	diferric-oxygen binding site [ion binding]; other site
517418001954	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
517418001955	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
517418001956	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
517418001957	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
517418001958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418001959	putative active site [active]
517418001960	heme pocket [chemical binding]; other site
517418001961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418001962	dimer interface [polypeptide binding]; other site
517418001963	phosphorylation site [posttranslational modification]
517418001964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418001965	ATP binding site [chemical binding]; other site
517418001966	Mg2+ binding site [ion binding]; other site
517418001967	G-X-G motif; other site
517418001968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001969	Response regulator receiver domain; Region: Response_reg; pfam00072
517418001970	active site
517418001971	phosphorylation site [posttranslational modification]
517418001972	intermolecular recognition site; other site
517418001973	dimerization interface [polypeptide binding]; other site
517418001974	Response regulator receiver domain; Region: Response_reg; pfam00072
517418001975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418001976	active site
517418001977	phosphorylation site [posttranslational modification]
517418001978	intermolecular recognition site; other site
517418001979	dimerization interface [polypeptide binding]; other site
517418001980	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
517418001981	putative binding surface; other site
517418001982	active site
517418001983	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
517418001984	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
517418001985	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
517418001986	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
517418001987	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517418001988	protein binding site [polypeptide binding]; other site
517418001989	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
517418001990	Catalytic dyad [active]
517418001991	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
517418001992	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
517418001993	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
517418001994	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418001995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001996	binding surface
517418001997	TPR motif; other site
517418001998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418001999	binding surface
517418002000	TPR motif; other site
517418002001	TPR repeat; Region: TPR_11; pfam13414
517418002002	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418002003	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418002004	binding surface
517418002005	TPR motif; other site
517418002006	trigger factor; Region: tig; TIGR00115
517418002007	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002008	dimer interface [polypeptide binding]; other site
517418002009	phosphorylation site [posttranslational modification]
517418002010	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
517418002011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002012	ATP binding site [chemical binding]; other site
517418002013	Mg2+ binding site [ion binding]; other site
517418002014	G-X-G motif; other site
517418002015	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
517418002016	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
517418002017	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517418002018	NAD(P) binding site [chemical binding]; other site
517418002019	putative active site [active]
517418002020	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
517418002021	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
517418002022	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
517418002023	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
517418002024	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
517418002025	dimer interface [polypeptide binding]; other site
517418002026	Citrate synthase; Region: Citrate_synt; pfam00285
517418002027	active site
517418002028	citrylCoA binding site [chemical binding]; other site
517418002029	NADH binding [chemical binding]; other site
517418002030	cationic pore residues; other site
517418002031	oxalacetate/citrate binding site [chemical binding]; other site
517418002032	coenzyme A binding site [chemical binding]; other site
517418002033	catalytic triad [active]
517418002034	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
517418002035	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
517418002036	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
517418002037	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
517418002038	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
517418002039	CcmE; Region: CcmE; cl00994
517418002040	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
517418002041	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
517418002042	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
517418002043	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
517418002044	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
517418002045	active site residue [active]
517418002046	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
517418002047	nudix motif; other site
517418002048	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
517418002049	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
517418002050	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
517418002051	dimer interface [polypeptide binding]; other site
517418002052	ADP-ribose binding site [chemical binding]; other site
517418002053	active site
517418002054	nudix motif; other site
517418002055	metal binding site [ion binding]; metal-binding site
517418002056	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
517418002057	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
517418002058	catalytic triad [active]
517418002059	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
517418002060	UbiA prenyltransferase family; Region: UbiA; cl00337
517418002061	Heme NO binding; Region: HNOB; cl15268
517418002062	PUCC protein; Region: PUCC; pfam03209
517418002063	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
517418002064	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
517418002065	Type III pantothenate kinase; Region: Pan_kinase; cl09130
517418002066	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
517418002067	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
517418002068	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
517418002069	NAD binding site [chemical binding]; other site
517418002070	homotetramer interface [polypeptide binding]; other site
517418002071	homodimer interface [polypeptide binding]; other site
517418002072	substrate binding site [chemical binding]; other site
517418002073	active site
517418002074	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
517418002075	4Fe-4S binding domain; Region: Fer4_5; pfam12801
517418002076	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
517418002077	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418002078	DTAP/Switch II; other site
517418002079	Switch I; other site
517418002080	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
517418002081	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
517418002082	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418002083	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
517418002084	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
517418002085	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
517418002086	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517418002087	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418002088	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418002089	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418002090	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
517418002091	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
517418002092	Cytochrome c; Region: Cytochrom_C; cl11414
517418002093	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
517418002094	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
517418002095	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
517418002096	DsrE/DsrF-like family; Region: DrsE; cl00672
517418002097	DsrC like protein; Region: DsrC; cl01101
517418002098	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
517418002099	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
517418002100	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
517418002101	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
517418002102	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
517418002103	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
517418002104	dimer interface [polypeptide binding]; other site
517418002105	ssDNA binding site [nucleotide binding]; other site
517418002106	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517418002107	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
517418002108	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418002109	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
517418002110	Walker A/P-loop; other site
517418002111	ATP binding site [chemical binding]; other site
517418002112	Q-loop/lid; other site
517418002113	ABC transporter signature motif; other site
517418002114	Walker B; other site
517418002115	D-loop; other site
517418002116	H-loop/switch region; other site
517418002117	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
517418002118	OPT oligopeptide transporter protein; Region: OPT; cl14607
517418002119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
517418002120	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
517418002121	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002122	dimer interface [polypeptide binding]; other site
517418002123	phosphorylation site [posttranslational modification]
517418002124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002125	ATP binding site [chemical binding]; other site
517418002126	Mg2+ binding site [ion binding]; other site
517418002127	G-X-G motif; other site
517418002128	Response regulator receiver domain; Region: Response_reg; pfam00072
517418002129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002130	active site
517418002131	phosphorylation site [posttranslational modification]
517418002132	intermolecular recognition site; other site
517418002133	dimerization interface [polypeptide binding]; other site
517418002134	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
517418002135	alanine aminotransferase; Validated; Region: PRK08363
517418002136	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517418002137	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418002138	homodimer interface [polypeptide binding]; other site
517418002139	catalytic residue [active]
517418002140	DivIVA protein; Region: DivIVA; pfam05103
517418002141	DivIVA domain; Region: DivI1A_domain; TIGR03544
517418002142	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
517418002143	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
517418002144	active site
517418002145	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
517418002146	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
517418002147	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243
517418002148	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
517418002149	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
517418002150	PA/protease or protease-like domain interface [polypeptide binding]; other site
517418002151	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
517418002152	metal binding site [ion binding]; metal-binding site
517418002153	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
517418002154	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
517418002155	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
517418002156	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
517418002157	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
517418002158	NAD(P) binding site [chemical binding]; other site
517418002159	homotetramer interface [polypeptide binding]; other site
517418002160	homodimer interface [polypeptide binding]; other site
517418002161	active site
517418002162	Acyl transferase domain; Region: Acyl_transf_1; cl08282
517418002163	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
517418002164	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
517418002165	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
517418002166	dimer interface [polypeptide binding]; other site
517418002167	active site
517418002168	CoA binding pocket [chemical binding]; other site
517418002169	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
517418002170	G1 box; other site
517418002171	GTP/Mg2+ binding site [chemical binding]; other site
517418002172	G2 box; other site
517418002173	Switch I region; other site
517418002174	G3 box; other site
517418002175	Switch II region; other site
517418002176	G4 box; other site
517418002177	G5 box; other site
517418002178	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
517418002179	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418002180	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
517418002181	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
517418002182	dimerization domain swap beta strand [polypeptide binding]; other site
517418002183	regulatory protein interface [polypeptide binding]; other site
517418002184	active site
517418002185	regulatory phosphorylation site [posttranslational modification]; other site
517418002186	GTPase CgtA; Reviewed; Region: obgE; PRK12299
517418002187	GTP1/OBG; Region: GTP1_OBG; pfam01018
517418002188	Obg GTPase; Region: Obg; cd01898
517418002189	G1 box; other site
517418002190	GTP/Mg2+ binding site [chemical binding]; other site
517418002191	Switch I region; other site
517418002192	G2 box; other site
517418002193	G3 box; other site
517418002194	Switch II region; other site
517418002195	G4 box; other site
517418002196	G5 box; other site
517418002197	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
517418002198	ATP cone domain; Region: ATP-cone; pfam03477
517418002199	Class III ribonucleotide reductase; Region: RNR_III; cd01675
517418002200	effector binding site; other site
517418002201	active site
517418002202	Zn binding site [ion binding]; other site
517418002203	glycine loop; other site
517418002204	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
517418002205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418002206	FeS/SAM binding site; other site
517418002207	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
517418002208	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
517418002209	dimer interface [polypeptide binding]; other site
517418002210	active site
517418002211	GAF domain; Region: GAF_2; pfam13185
517418002212	GAF domain; Region: GAF; cl15785
517418002213	PAS domain S-box; Region: sensory_box; TIGR00229
517418002214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002215	putative active site [active]
517418002216	heme pocket [chemical binding]; other site
517418002217	PAS fold; Region: PAS_4; pfam08448
517418002218	PAS fold; Region: PAS_3; pfam08447
517418002219	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418002220	hypothetical protein; Provisional; Region: PRK13560
517418002221	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418002222	histidine kinase; Provisional; Region: PRK13557
517418002223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002224	putative active site [active]
517418002225	heme pocket [chemical binding]; other site
517418002226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002227	dimer interface [polypeptide binding]; other site
517418002228	phosphorylation site [posttranslational modification]
517418002229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002230	ATP binding site [chemical binding]; other site
517418002231	Mg2+ binding site [ion binding]; other site
517418002232	G-X-G motif; other site
517418002233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002234	active site
517418002235	phosphorylation site [posttranslational modification]
517418002236	intermolecular recognition site; other site
517418002237	dimerization interface [polypeptide binding]; other site
517418002238	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
517418002239	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
517418002240	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
517418002241	putative active site [active]
517418002242	catalytic residue [active]
517418002243	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002244	G1 box; other site
517418002245	GTP/Mg2+ binding site [chemical binding]; other site
517418002246	G2 box; other site
517418002247	Switch I region; other site
517418002248	G3 box; other site
517418002249	Switch II region; other site
517418002250	G4 box; other site
517418002251	G5 box; other site
517418002252	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
517418002253	MoxR-like ATPases [General function prediction only]; Region: COG0714
517418002254	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002255	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
517418002256	pyruvate phosphate dikinase; Provisional; Region: PRK09279
517418002257	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
517418002258	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
517418002259	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
517418002260	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
517418002261	TM-ABC transporter signature motif; other site
517418002262	Clp protease; Region: CLP_protease; pfam00574
517418002263	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
517418002264	oligomer interface [polypeptide binding]; other site
517418002265	active site residues [active]
517418002266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002267	PAS fold; Region: PAS_3; pfam08447
517418002268	putative active site [active]
517418002269	heme pocket [chemical binding]; other site
517418002270	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002271	dimer interface [polypeptide binding]; other site
517418002272	phosphorylation site [posttranslational modification]
517418002273	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
517418002274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002275	ATP binding site [chemical binding]; other site
517418002276	G-X-G motif; other site
517418002277	Uncharacterized conserved protein [Function unknown]; Region: COG2898
517418002278	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
517418002279	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
517418002280	IHF - DNA interface [nucleotide binding]; other site
517418002281	IHF dimer interface [polypeptide binding]; other site
517418002282	elongation factor P; Validated; Region: PRK00529
517418002283	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
517418002284	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
517418002285	RNA binding site [nucleotide binding]; other site
517418002286	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
517418002287	RNA binding site [nucleotide binding]; other site
517418002288	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
517418002289	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
517418002290	carboxyltransferase (CT) interaction site; other site
517418002291	biotinylation site [posttranslational modification]; other site
517418002292	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
517418002293	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517418002294	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418002295	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
517418002296	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
517418002297	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
517418002298	dimer interface [polypeptide binding]; other site
517418002299	anticodon binding site; other site
517418002300	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
517418002301	homodimer interface [polypeptide binding]; other site
517418002302	motif 1; other site
517418002303	active site
517418002304	motif 2; other site
517418002305	GAD domain; Region: GAD; pfam02938
517418002306	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
517418002307	active site
517418002308	motif 3; other site
517418002309	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
517418002310	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
517418002311	putative active site [active]
517418002312	catalytic triad [active]
517418002313	putative dimer interface [polypeptide binding]; other site
517418002314	Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
517418002315	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
517418002316	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
517418002317	active site
517418002318	dimer interface [polypeptide binding]; other site
517418002319	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
517418002320	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
517418002321	active site
517418002322	FMN binding site [chemical binding]; other site
517418002323	substrate binding site [chemical binding]; other site
517418002324	3Fe-4S cluster binding site [ion binding]; other site
517418002325	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
517418002326	domain_subunit interface; other site
517418002327	secreted effector protein PipB2; Provisional; Region: PRK15196
517418002328	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517418002329	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517418002330	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517418002331	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517418002332	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517418002333	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517418002334	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517418002335	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
517418002336	trimer interface [polypeptide binding]; other site
517418002337	active site
517418002338	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
517418002339	DNA-binding site [nucleotide binding]; DNA binding site
517418002340	RNA-binding motif; other site
517418002341	EamA-like transporter family; Region: EamA; cl01037
517418002342	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
517418002343	Ubiquitin-like proteins; Region: UBQ; cl00155
517418002344	charged pocket; other site
517418002345	hydrophobic patch; other site
517418002346	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
517418002347	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
517418002348	ATP binding site [chemical binding]; other site
517418002349	substrate interface [chemical binding]; other site
517418002350	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
517418002351	active site residue [active]
517418002352	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
517418002353	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
517418002354	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
517418002355	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
517418002356	Int/Topo IB signature motif; other site
517418002357	active site
517418002358	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
517418002359	30S subunit binding site; other site
517418002360	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
517418002361	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
517418002362	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
517418002363	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
517418002364	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
517418002365	putative active site [active]
517418002366	dimer interface [polypeptide binding]; other site
517418002367	substrate binding site [chemical binding]; other site
517418002368	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002369	Dynamin family; Region: Dynamin_N; pfam00350
517418002370	G1 box; other site
517418002371	GTP/Mg2+ binding site [chemical binding]; other site
517418002372	G2 box; other site
517418002373	Switch I region; other site
517418002374	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002375	G3 box; other site
517418002376	Switch II region; other site
517418002377	G4 box; other site
517418002378	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
517418002379	ScpA/B protein; Region: ScpA_ScpB; cl00598
517418002380	Response regulator receiver domain; Region: Response_reg; pfam00072
517418002381	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002382	active site
517418002383	phosphorylation site [posttranslational modification]
517418002384	intermolecular recognition site; other site
517418002385	dimerization interface [polypeptide binding]; other site
517418002386	Response regulator receiver domain; Region: Response_reg; pfam00072
517418002387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002388	active site
517418002389	phosphorylation site [posttranslational modification]
517418002390	intermolecular recognition site; other site
517418002391	dimerization interface [polypeptide binding]; other site
517418002392	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517418002393	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002394	dimer interface [polypeptide binding]; other site
517418002395	phosphorylation site [posttranslational modification]
517418002396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002397	ATP binding site [chemical binding]; other site
517418002398	Mg2+ binding site [ion binding]; other site
517418002399	G-X-G motif; other site
517418002400	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
517418002401	TIGR01777 family protein; Region: yfcH
517418002402	putative NAD(P) binding site [chemical binding]; other site
517418002403	putative active site [active]
517418002404	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
517418002405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002406	ATP binding site [chemical binding]; other site
517418002407	Mg2+ binding site [ion binding]; other site
517418002408	G-X-G motif; other site
517418002409	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
517418002410	ATP binding site [chemical binding]; other site
517418002411	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
517418002412	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
517418002413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002414	active site
517418002415	phosphorylation site [posttranslational modification]
517418002416	intermolecular recognition site; other site
517418002417	dimerization interface [polypeptide binding]; other site
517418002418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418002419	Walker A motif; other site
517418002420	ATP binding site [chemical binding]; other site
517418002421	Walker B motif; other site
517418002422	arginine finger; other site
517418002423	Helix-turn-helix domains; Region: HTH; cl00088
517418002424	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
517418002425	DNA binding site [nucleotide binding]
517418002426	active site
517418002427	classical (c) SDRs; Region: SDR_c; cd05233
517418002428	NAD(P) binding site [chemical binding]; other site
517418002429	active site
517418002430	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
517418002431	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
517418002432	heterodimer interface [polypeptide binding]; other site
517418002433	active site
517418002434	FMN binding site [chemical binding]; other site
517418002435	homodimer interface [polypeptide binding]; other site
517418002436	substrate binding site [chemical binding]; other site
517418002437	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517418002438	catalytic residues [active]
517418002439	NurA domain; Region: NurA; cl09134
517418002440	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
517418002441	universal stress protein UspE; Provisional; Region: PRK11175
517418002442	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418002443	Ligand Binding Site [chemical binding]; other site
517418002444	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418002445	Ligand Binding Site [chemical binding]; other site
517418002446	Bacitracin resistance protein BacA; Region: BacA; cl00858
517418002447	Haem-binding domain; Region: Haem_bd; pfam14376
517418002448	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
517418002449	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
517418002450	putative active site [active]
517418002451	putative FMN binding site [chemical binding]; other site
517418002452	putative substrate binding site [chemical binding]; other site
517418002453	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
517418002454	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
517418002455	dimer interface [polypeptide binding]; other site
517418002456	PYR/PP interface [polypeptide binding]; other site
517418002457	TPP binding site [chemical binding]; other site
517418002458	substrate binding site [chemical binding]; other site
517418002459	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
517418002460	Domain of unknown function; Region: EKR; cl11037
517418002461	4Fe-4S binding domain; Region: Fer4; cl02805
517418002462	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
517418002463	TPP-binding site [chemical binding]; other site
517418002464	dimer interface [polypeptide binding]; other site
517418002465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002466	PAS domain; Region: PAS_9; pfam13426
517418002467	putative active site [active]
517418002468	heme pocket [chemical binding]; other site
517418002469	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418002470	FeS/SAM binding site; other site
517418002471	Radical SAM superfamily; Region: Radical_SAM; pfam04055
517418002472	Divergent AAA domain; Region: AAA_4; pfam04326
517418002473	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
517418002474	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
517418002475	Cytochrome c; Region: Cytochrom_C; cl11414
517418002476	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
517418002477	active site
517418002478	putative substrate binding region [chemical binding]; other site
517418002479	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418002480	binding surface
517418002481	TPR motif; other site
517418002482	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
517418002483	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517418002484	active site
517418002485	HIGH motif; other site
517418002486	nucleotide binding site [chemical binding]; other site
517418002487	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517418002488	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517418002489	active site
517418002490	KMSKS motif; other site
517418002491	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
517418002492	tRNA binding surface [nucleotide binding]; other site
517418002493	anticodon binding site; other site
517418002494	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
517418002495	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
517418002496	amidophosphoribosyltransferase; Provisional; Region: PRK09123
517418002497	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
517418002498	active site
517418002499	tetramer interface [polypeptide binding]; other site
517418002500	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418002501	active site
517418002502	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
517418002503	Domain of unknown function DUF21; Region: DUF21; pfam01595
517418002504	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
517418002505	Transporter associated domain; Region: CorC_HlyC; cl08393
517418002506	FtsX-like permease family; Region: FtsX; cl15850
517418002507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
517418002508	FecR protein; Region: FecR; pfam04773
517418002509	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
517418002510	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
517418002511	CTP synthetase; Validated; Region: pyrG; PRK05380
517418002512	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
517418002513	Catalytic site [active]
517418002514	active site
517418002515	UTP binding site [chemical binding]; other site
517418002516	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
517418002517	active site
517418002518	putative oxyanion hole; other site
517418002519	catalytic triad [active]
517418002520	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
517418002521	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418002522	structural tetrad; other site
517418002523	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
517418002524	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
517418002525	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
517418002526	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418002527	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
517418002528	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
517418002529	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
517418002530	Protein of unknown function (DUF456); Region: DUF456; cl01069
517418002531	GTPase RsgA; Reviewed; Region: PRK01889
517418002532	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517418002533	RNA binding site [nucleotide binding]; other site
517418002534	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
517418002535	GTPase/Zn-binding domain interface [polypeptide binding]; other site
517418002536	GTP/Mg2+ binding site [chemical binding]; other site
517418002537	G4 box; other site
517418002538	G5 box; other site
517418002539	G1 box; other site
517418002540	Switch I region; other site
517418002541	G2 box; other site
517418002542	G3 box; other site
517418002543	Switch II region; other site
517418002544	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
517418002545	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418002546	FeS/SAM binding site; other site
517418002547	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
517418002548	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
517418002549	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
517418002550	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
517418002551	active site
517418002552	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
517418002553	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
517418002554	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
517418002555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002556	Helix-turn-helix domain; Region: HTH_18; pfam12833
517418002557	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418002558	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
517418002559	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
517418002560	NADP binding site [chemical binding]; other site
517418002561	homotetramer interface [polypeptide binding]; other site
517418002562	homodimer interface [polypeptide binding]; other site
517418002563	active site
517418002564	Rhomboid family; Region: Rhomboid; cl11446
517418002565	Phosphoglycerate kinase; Region: PGK; pfam00162
517418002566	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
517418002567	substrate binding site [chemical binding]; other site
517418002568	hinge regions; other site
517418002569	ADP binding site [chemical binding]; other site
517418002570	catalytic site [active]
517418002571	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002572	PAS domain; Region: PAS_9; pfam13426
517418002573	putative active site [active]
517418002574	heme pocket [chemical binding]; other site
517418002575	PAS domain; Region: PAS_9; pfam13426
517418002576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002577	putative active site [active]
517418002578	heme pocket [chemical binding]; other site
517418002579	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002580	putative active site [active]
517418002581	heme pocket [chemical binding]; other site
517418002582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418002583	PAS domain S-box; Region: sensory_box; TIGR00229
517418002584	hypothetical protein; Provisional; Region: PRK13560
517418002585	PAS domain S-box; Region: sensory_box; TIGR00229
517418002586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418002587	putative active site [active]
517418002588	heme pocket [chemical binding]; other site
517418002589	sensor protein ZraS; Provisional; Region: PRK10364
517418002590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002591	ATP binding site [chemical binding]; other site
517418002592	Mg2+ binding site [ion binding]; other site
517418002593	G-X-G motif; other site
517418002594	Response regulator receiver domain; Region: Response_reg; pfam00072
517418002595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002596	active site
517418002597	phosphorylation site [posttranslational modification]
517418002598	intermolecular recognition site; other site
517418002599	dimerization interface [polypeptide binding]; other site
517418002600	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
517418002601	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
517418002602	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
517418002603	dimer interface [polypeptide binding]; other site
517418002604	active site
517418002605	metal binding site [ion binding]; metal-binding site
517418002606	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
517418002607	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
517418002608	active site
517418002609	catalytic tetrad [active]
517418002610	Helix-turn-helix domain; Region: HTH_18; pfam12833
517418002611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418002612	OstA-like protein; Region: OstA_2; pfam13100
517418002613	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
517418002614	active site
517418002615	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
517418002616	homodimer interface [polypeptide binding]; other site
517418002617	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418002618	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
517418002619	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
517418002620	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
517418002621	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002622	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
517418002623	catalytic triad [active]
517418002624	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
517418002625	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
517418002626	FMN binding site [chemical binding]; other site
517418002627	active site
517418002628	catalytic residues [active]
517418002629	substrate binding site [chemical binding]; other site
517418002630	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
517418002631	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
517418002632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418002633	TPR motif; other site
517418002634	TPR repeat; Region: TPR_11; pfam13414
517418002635	binding surface
517418002636	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
517418002637	nucleotide binding site/active site [active]
517418002638	HIT family signature motif; other site
517418002639	catalytic residue [active]
517418002640	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418002641	metal binding site [ion binding]; metal-binding site
517418002642	active site
517418002643	I-site; other site
517418002644	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
517418002645	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
517418002646	substrate binding site [chemical binding]; other site
517418002647	hexamer interface [polypeptide binding]; other site
517418002648	metal binding site [ion binding]; metal-binding site
517418002649	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418002650	Fic family protein [Function unknown]; Region: COG3177
517418002651	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
517418002652	Fic/DOC family; Region: Fic; cl00960
517418002653	Helix-turn-helix domains; Region: HTH; cl00088
517418002654	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
517418002655	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
517418002656	trmE is a tRNA modification GTPase; Region: trmE; cd04164
517418002657	G1 box; other site
517418002658	GTP/Mg2+ binding site [chemical binding]; other site
517418002659	Switch I region; other site
517418002660	G2 box; other site
517418002661	Switch II region; other site
517418002662	G3 box; other site
517418002663	G4 box; other site
517418002664	G5 box; other site
517418002665	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
517418002666	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
517418002667	homopentamer interface [polypeptide binding]; other site
517418002668	active site
517418002669	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
517418002670	dimer interface [polypeptide binding]; other site
517418002671	active site
517418002672	PIF1-like helicase; Region: PIF1; pfam05970
517418002673	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002674	Family description; Region: UvrD_C_2; cl15862
517418002675	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
517418002676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002677	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
517418002678	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
517418002679	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418002680	FeS/SAM binding site; other site
517418002681	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418002682	structural tetrad; other site
517418002683	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
517418002684	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517418002685	putative active site [active]
517418002686	metal binding site [ion binding]; metal-binding site
517418002687	homodimer binding site [polypeptide binding]; other site
517418002688	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517418002689	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
517418002690	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
517418002691	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
517418002692	This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity.  In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs.  Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269
517418002693	Walker A/P-loop; other site
517418002694	ATP binding site [chemical binding]; other site
517418002695	Q-loop/lid; other site
517418002696	ABC transporter signature motif; other site
517418002697	Walker B; other site
517418002698	D-loop; other site
517418002699	H-loop/switch region; other site
517418002700	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
517418002701	YceG-like family; Region: YceG; pfam02618
517418002702	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
517418002703	dimerization interface [polypeptide binding]; other site
517418002704	Chorismate mutase type II; Region: CM_2; cl00693
517418002705	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
517418002706	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
517418002707	YacP-like NYN domain; Region: NYN_YacP; cl01491
517418002708	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
517418002709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002710	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
517418002711	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
517418002712	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418002713	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
517418002714	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
517418002715	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
517418002716	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517418002717	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517418002718	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517418002719	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
517418002720	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517418002721	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517418002722	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517418002723	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
517418002724	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
517418002725	Mg++ binding site [ion binding]; other site
517418002726	putative catalytic motif [active]
517418002727	putative substrate binding site [chemical binding]; other site
517418002728	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
517418002729	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517418002730	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517418002731	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
517418002732	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
517418002733	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
517418002734	active site
517418002735	homodimer interface [polypeptide binding]; other site
517418002736	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
517418002737	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517418002738	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517418002739	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517418002740	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
517418002741	catalytic motif [active]
517418002742	Catalytic residue [active]
517418002743	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
517418002744	FAD binding domain; Region: FAD_binding_4; pfam01565
517418002745	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
517418002746	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
517418002747	cell division protein FtsA; Region: ftsA; TIGR01174
517418002748	Cell division protein FtsA; Region: FtsA; cl11496
517418002749	Cell division protein FtsA; Region: FtsA; cl11496
517418002750	cell division protein FtsZ; Validated; Region: PRK09330
517418002751	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
517418002752	nucleotide binding site [chemical binding]; other site
517418002753	SulA interaction site; other site
517418002754	H+ Antiporter protein; Region: 2A0121; TIGR00900
517418002755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418002756	putative substrate translocation pore; other site
517418002757	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
517418002758	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418002759	ligand binding site [chemical binding]; other site
517418002760	flexible hinge region; other site
517418002761	Helix-turn-helix domains; Region: HTH; cl00088
517418002762	DNA polymerase III subunit beta; Provisional; Region: PRK14941
517418002763	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
517418002764	putative DNA binding surface [nucleotide binding]; other site
517418002765	dimer interface [polypeptide binding]; other site
517418002766	beta-clamp/clamp loader binding surface; other site
517418002767	beta-clamp/translesion DNA polymerase binding surface; other site
517418002768	recombination protein F; Reviewed; Region: recF; PRK00064
517418002769	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002770	Walker A/P-loop; other site
517418002771	ATP binding site [chemical binding]; other site
517418002772	Q-loop/lid; other site
517418002773	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418002774	ABC transporter signature motif; other site
517418002775	Walker B; other site
517418002776	D-loop; other site
517418002777	H-loop/switch region; other site
517418002778	Protein of unknown function (DUF721); Region: DUF721; cl02324
517418002779	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418002780	Predicted transcriptional regulator [Transcription]; Region: COG2944
517418002781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
517418002782	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
517418002783	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
517418002784	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
517418002785	active site
517418002786	substrate binding site [chemical binding]; other site
517418002787	coenzyme B12 binding site [chemical binding]; other site
517418002788	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
517418002789	B12 binding site [chemical binding]; other site
517418002790	cobalt ligand [ion binding]; other site
517418002791	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
517418002792	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
517418002793	heterodimer interface [polypeptide binding]; other site
517418002794	substrate interaction site [chemical binding]; other site
517418002795	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517418002796	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
517418002797	tetramer interfaces [polypeptide binding]; other site
517418002798	binuclear metal-binding site [ion binding]; other site
517418002799	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
517418002800	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
517418002801	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
517418002802	Walker A/P-loop; other site
517418002803	ATP binding site [chemical binding]; other site
517418002804	Q-loop/lid; other site
517418002805	ABC transporter signature motif; other site
517418002806	Walker B; other site
517418002807	D-loop; other site
517418002808	H-loop/switch region; other site
517418002809	Plant ATP synthase F0; Region: YMF19; cl07975
517418002810	Smr domain; Region: Smr; cl02619
517418002811	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418002812	Ligand Binding Site [chemical binding]; other site
517418002813	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418002814	Ligand Binding Site [chemical binding]; other site
517418002815	DEAD-like helicases superfamily; Region: DEXDc; smart00487
517418002816	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517418002817	ATP binding site [chemical binding]; other site
517418002818	putative Mg++ binding site [ion binding]; other site
517418002819	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418002820	nucleotide binding region [chemical binding]; other site
517418002821	ATP-binding site [chemical binding]; other site
517418002822	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
517418002823	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
517418002824	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002825	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002826	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
517418002827	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
517418002828	DNA polymerase type-B family; Region: POLBc; smart00486
517418002829	active site
517418002830	catalytic site [active]
517418002831	substrate binding site [chemical binding]; other site
517418002832	DNA polymerase family B; Region: DNA_pol_B; pfam00136
517418002833	DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023
517418002834	active site
517418002835	metal-binding site
517418002836	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
517418002837	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
517418002838	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
517418002839	trimer interface [polypeptide binding]; other site
517418002840	dimer interface [polypeptide binding]; other site
517418002841	putative active site [active]
517418002842	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
517418002843	MPT binding site; other site
517418002844	trimer interface [polypeptide binding]; other site
517418002845	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
517418002846	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
517418002847	dimer interface [polypeptide binding]; other site
517418002848	putative functional site; other site
517418002849	putative MPT binding site; other site
517418002850	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517418002851	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
517418002852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
517418002853	Helix-turn-helix domains; Region: HTH; cl00088
517418002854	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
517418002855	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
517418002856	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
517418002857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418002858	catalytic residue [active]
517418002859	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002860	dimer interface [polypeptide binding]; other site
517418002861	phosphorylation site [posttranslational modification]
517418002862	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002863	ATP binding site [chemical binding]; other site
517418002864	Mg2+ binding site [ion binding]; other site
517418002865	G-X-G motif; other site
517418002866	TPR repeat; Region: TPR_11; pfam13414
517418002867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418002868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418002869	homoserine kinase; Provisional; Region: PRK01212
517418002870	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
517418002871	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
517418002872	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
517418002873	beta subunit interaction interface [polypeptide binding]; other site
517418002874	Walker A motif; other site
517418002875	ATP binding site [chemical binding]; other site
517418002876	Walker B motif; other site
517418002877	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
517418002878	ATP synthase; Region: ATP-synt; cl00365
517418002879	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
517418002880	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
517418002881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418002882	FeS/SAM binding site; other site
517418002883	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
517418002884	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
517418002885	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
517418002886	Substrate binding site; other site
517418002887	metal-binding site
517418002888	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
517418002889	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
517418002890	glycogen synthase; Provisional; Region: glgA; PRK00654
517418002891	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
517418002892	ADP-binding pocket [chemical binding]; other site
517418002893	homodimer interface [polypeptide binding]; other site
517418002894	flavoprotein, HI0933 family; Region: TIGR00275
517418002895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002896	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
517418002897	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418002898	FeS/SAM binding site; other site
517418002899	HemN C-terminal domain; Region: HemN_C; pfam06969
517418002900	chaperone protein HscA; Provisional; Region: hscA; PRK05183
517418002901	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
517418002902	MgATP binding site [chemical binding]; other site
517418002903	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
517418002904	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
517418002905	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
517418002906	DNA binding site [nucleotide binding]
517418002907	Int/Topo IB signature motif; other site
517418002908	active site
517418002909	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
517418002910	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
517418002911	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418002912	catalytic residue [active]
517418002913	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
517418002914	active site residue [active]
517418002915	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
517418002916	LexA repressor; Provisional; Region: PRK12423
517418002917	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
517418002918	Catalytic site [active]
517418002919	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
517418002920	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
517418002921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418002922	dimer interface [polypeptide binding]; other site
517418002923	phosphorylation site [posttranslational modification]
517418002924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418002925	ATP binding site [chemical binding]; other site
517418002926	Mg2+ binding site [ion binding]; other site
517418002927	G-X-G motif; other site
517418002928	Response regulator receiver domain; Region: Response_reg; pfam00072
517418002929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002930	active site
517418002931	phosphorylation site [posttranslational modification]
517418002932	intermolecular recognition site; other site
517418002933	dimerization interface [polypeptide binding]; other site
517418002934	Response regulator receiver domain; Region: Response_reg; pfam00072
517418002935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418002936	active site
517418002937	phosphorylation site [posttranslational modification]
517418002938	intermolecular recognition site; other site
517418002939	dimerization interface [polypeptide binding]; other site
517418002940	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
517418002941	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
517418002942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418002943	putative substrate translocation pore; other site
517418002944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418002945	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
517418002946	TIR domain; Region: TIR_2; cl15770
517418002947	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002948	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
517418002949	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
517418002950	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
517418002951	putative NAD(P) binding site [chemical binding]; other site
517418002952	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517418002953	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418002954	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
517418002955	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
517418002956	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
517418002957	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
517418002958	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
517418002959	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
517418002960	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
517418002961	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
517418002962	IHF dimer interface [polypeptide binding]; other site
517418002963	IHF - DNA interface [nucleotide binding]; other site
517418002964	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
517418002965	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
517418002966	active site
517418002967	metal binding site [ion binding]; metal-binding site
517418002968	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
517418002969	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
517418002970	catalytic site [active]
517418002971	G-X2-G-X-G-K; other site
517418002972	hypothetical protein; Provisional; Region: PRK11820
517418002973	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
517418002974	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
517418002975	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418002976	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
517418002977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418002978	dimer interface [polypeptide binding]; other site
517418002979	conserved gate region; other site
517418002980	putative PBP binding loops; other site
517418002981	ABC-ATPase subunit interface; other site
517418002982	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
517418002983	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418002984	dimer interface [polypeptide binding]; other site
517418002985	conserved gate region; other site
517418002986	putative PBP binding loops; other site
517418002987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
517418002988	ABC-ATPase subunit interface; other site
517418002989	phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972
517418002990	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
517418002991	Walker A/P-loop; other site
517418002992	ATP binding site [chemical binding]; other site
517418002993	Q-loop/lid; other site
517418002994	ABC transporter signature motif; other site
517418002995	Walker B; other site
517418002996	D-loop; other site
517418002997	H-loop/switch region; other site
517418002998	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
517418002999	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
517418003000	Walker A/P-loop; other site
517418003001	ATP binding site [chemical binding]; other site
517418003002	Q-loop/lid; other site
517418003003	ABC transporter signature motif; other site
517418003004	Walker B; other site
517418003005	D-loop; other site
517418003006	H-loop/switch region; other site
517418003007	Cupin domain; Region: Cupin_2; cl09118
517418003008	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
517418003009	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
517418003010	substrate binding site [chemical binding]; other site
517418003011	active site
517418003012	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418003013	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
517418003014	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517418003015	catalytic loop [active]
517418003016	iron binding site [ion binding]; other site
517418003017	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
517418003018	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
517418003019	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
517418003020	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
517418003021	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
517418003022	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
517418003023	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418003024	binding surface
517418003025	TPR motif; other site
517418003026	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
517418003027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
517418003028	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
517418003029	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
517418003030	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
517418003031	Helix-turn-helix domains; Region: HTH; cl00088
517418003032	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
517418003033	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
517418003034	FeoA domain; Region: FeoA; cl00838
517418003035	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
517418003036	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
517418003037	Ligand binding site; other site
517418003038	Putative Catalytic site; other site
517418003039	DXD motif; other site
517418003040	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
517418003041	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
517418003042	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
517418003043	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
517418003044	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
517418003045	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
517418003046	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634
517418003047	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
517418003048	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
517418003049	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
517418003050	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
517418003051	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
517418003052	N-carbamolyputrescine amidase; Region: PLN02747
517418003053	putative active site; other site
517418003054	catalytic triad [active]
517418003055	putative dimer interface [polypeptide binding]; other site
517418003056	UbiA prenyltransferase family; Region: UbiA; cl00337
517418003057	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
517418003058	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418003059	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
517418003060	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
517418003061	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003062	N-terminal plug; other site
517418003063	ligand-binding site [chemical binding]; other site
517418003064	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
517418003065	putative PBP binding regions; other site
517418003066	ABC-ATPase subunit  interface; other site
517418003067	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
517418003068	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
517418003069	Walker A/P-loop; other site
517418003070	ATP binding site [chemical binding]; other site
517418003071	Q-loop/lid; other site
517418003072	ABC transporter signature motif; other site
517418003073	Walker B; other site
517418003074	D-loop; other site
517418003075	H-loop/switch region; other site
517418003076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003077	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
517418003078	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
517418003079	putative ligand binding residues [chemical binding]; other site
517418003080	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418003081	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003082	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
517418003083	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003084	Walker A/P-loop; other site
517418003085	ATP binding site [chemical binding]; other site
517418003086	ABC transporter; Region: ABC_tran; pfam00005
517418003087	Q-loop/lid; other site
517418003088	ABC transporter signature motif; other site
517418003089	Walker B; other site
517418003090	D-loop; other site
517418003091	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
517418003092	glycyl-tRNA synthetase; Provisional; Region: PRK04173
517418003093	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
517418003094	motif 1; other site
517418003095	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
517418003096	active site
517418003097	motif 2; other site
517418003098	motif 3; other site
517418003099	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
517418003100	anticodon binding site; other site
517418003101	Permease; Region: Permease; cl00510
517418003102	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
517418003103	glycyl-tRNA synthetase; Region: PLN02734
517418003104	Rhomboid family; Region: Rhomboid; cl11446
517418003105	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
517418003106	classical (c) SDRs; Region: SDR_c; cd05233
517418003107	NAD(P) binding site [chemical binding]; other site
517418003108	active site
517418003109	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
517418003110	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
517418003111	phytoene desaturase; Region: crtI_fam; TIGR02734
517418003112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003113	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
517418003114	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
517418003115	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
517418003116	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
517418003117	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
517418003118	active site
517418003119	catalytic tetrad [active]
517418003120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418003121	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
517418003122	Walker A motif; other site
517418003123	ATP binding site [chemical binding]; other site
517418003124	Walker B motif; other site
517418003125	arginine finger; other site
517418003126	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
517418003127	Helix-turn-helix domains; Region: HTH; cl00088
517418003128	Aerotolerance regulator N-terminal; Region: BatA; cl06567
517418003129	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418003130	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
517418003131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517418003132	Coenzyme A binding pocket [chemical binding]; other site
517418003133	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
517418003134	NlpC/P60 family; Region: NLPC_P60; cl11438
517418003135	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
517418003136	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003137	N-terminal plug; other site
517418003138	ligand-binding site [chemical binding]; other site
517418003139	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003140	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
517418003141	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003142	N-terminal plug; other site
517418003143	ligand-binding site [chemical binding]; other site
517418003144	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
517418003145	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003146	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
517418003147	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003148	N-terminal plug; other site
517418003149	ligand-binding site [chemical binding]; other site
517418003150	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
517418003151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418003152	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
517418003153	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418003154	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003155	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
517418003156	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003157	N-terminal plug; other site
517418003158	ligand-binding site [chemical binding]; other site
517418003159	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
517418003160	EamA-like transporter family; Region: EamA; cl01037
517418003161	EamA-like transporter family; Region: EamA; cl01037
517418003162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003163	S-adenosylmethionine binding site [chemical binding]; other site
517418003164	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003165	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
517418003166	Leucine carboxyl methyltransferase; Region: LCM; cl01306
517418003167	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517418003168	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
517418003169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003170	Walker A/P-loop; other site
517418003171	ATP binding site [chemical binding]; other site
517418003172	Q-loop/lid; other site
517418003173	ABC transporter signature motif; other site
517418003174	Walker B; other site
517418003175	D-loop; other site
517418003176	H-loop/switch region; other site
517418003177	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517418003178	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
517418003179	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003180	Walker A/P-loop; other site
517418003181	ATP binding site [chemical binding]; other site
517418003182	Q-loop/lid; other site
517418003183	ABC transporter signature motif; other site
517418003184	Walker B; other site
517418003185	D-loop; other site
517418003186	H-loop/switch region; other site
517418003187	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
517418003188	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003189	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
517418003190	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003191	N-terminal plug; other site
517418003192	ligand-binding site [chemical binding]; other site
517418003193	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
517418003194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418003195	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003196	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
517418003197	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003198	N-terminal plug; other site
517418003199	ligand-binding site [chemical binding]; other site
517418003200	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
517418003201	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
517418003202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
517418003203	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
517418003204	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
517418003205	putative active site [active]
517418003206	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003207	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
517418003208	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003209	N-terminal plug; other site
517418003210	ligand-binding site [chemical binding]; other site
517418003211	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472
517418003212	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418003213	Protein of unknown function DUF262; Region: DUF262; cl14890
517418003214	Protein of unknown function DUF262; Region: DUF262; cl14890
517418003215	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
517418003216	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
517418003217	putative active site [active]
517418003218	metal binding site [ion binding]; metal-binding site
517418003219	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
517418003220	YokU-like protein; Region: YokU; cl15819
517418003221	integron integrase; Region: integrase_gron; TIGR02249
517418003222	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
517418003223	Int/Topo IB signature motif; other site
517418003224	YfjP GTPase; Region: YfjP; cd11383
517418003225	GTP/Mg2+ binding site [chemical binding]; other site
517418003226	Switch I region; other site
517418003227	G2 box; other site
517418003228	Switch II region; other site
517418003229	G3 box; other site
517418003230	G4 box; other site
517418003231	G5 box; other site
517418003232	YfjP GTPase; Region: YfjP; cd11383
517418003233	G1 box; other site
517418003234	GTP/Mg2+ binding site [chemical binding]; other site
517418003235	Switch I region; other site
517418003236	G2 box; other site
517418003237	Switch II region; other site
517418003238	G3 box; other site
517418003239	G4 box; other site
517418003240	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
517418003241	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
517418003242	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
517418003243	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
517418003244	dimer interface [polypeptide binding]; other site
517418003245	[2Fe-2S] cluster binding site [ion binding]; other site
517418003246	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
517418003247	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418003248	FeS/SAM binding site; other site
517418003249	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
517418003250	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517418003251	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
517418003252	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
517418003253	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
517418003254	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
517418003255	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
517418003256	MoFe protein beta/alpha subunit interactions; other site
517418003257	Beta subunit P cluster binding residues; other site
517418003258	MoFe protein beta subunit/Fe protein contacts; other site
517418003259	MoFe protein dimer/ dimer interactions; other site
517418003260	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517418003261	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
517418003262	Nitrogen regulatory protein P-II; Region: P-II; cl00412
517418003263	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517418003264	Nitrogen regulatory protein P-II; Region: P-II; cl00412
517418003265	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517418003266	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
517418003267	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
517418003268	Nucleotide-binding sites [chemical binding]; other site
517418003269	Walker A motif; other site
517418003270	Switch I region of nucleotide binding site; other site
517418003271	Fe4S4 binding sites [ion binding]; other site
517418003272	Switch II region of nucleotide binding site; other site
517418003273	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
517418003274	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
517418003275	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
517418003276	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
517418003277	trimer interface [polypeptide binding]; other site
517418003278	putative metal binding site [ion binding]; other site
517418003279	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
517418003280	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
517418003281	Walker A/P-loop; other site
517418003282	ATP binding site [chemical binding]; other site
517418003283	Q-loop/lid; other site
517418003284	ABC transporter signature motif; other site
517418003285	Walker B; other site
517418003286	D-loop; other site
517418003287	H-loop/switch region; other site
517418003288	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
517418003289	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517418003290	active site
517418003291	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517418003292	active site
517418003293	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
517418003294	RIP metalloprotease RseP; Region: TIGR00054
517418003295	active site
517418003296	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
517418003297	protein binding site [polypeptide binding]; other site
517418003298	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
517418003299	protein binding site [polypeptide binding]; other site
517418003300	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
517418003301	putative substrate binding region [chemical binding]; other site
517418003302	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
517418003303	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
517418003304	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
517418003305	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
517418003306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
517418003307	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
517418003308	amidase catalytic site [active]
517418003309	Zn binding residues [ion binding]; other site
517418003310	substrate binding site [chemical binding]; other site
517418003311	Bacterial SH3 domain; Region: SH3_3; cl02551
517418003312	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
517418003313	enolase; Provisional; Region: eno; PRK00077
517418003314	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
517418003315	dimer interface [polypeptide binding]; other site
517418003316	metal binding site [ion binding]; metal-binding site
517418003317	substrate binding pocket [chemical binding]; other site
517418003318	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
517418003319	AMP-binding enzyme; Region: AMP-binding; cl15778
517418003320	AMP-binding enzyme; Region: AMP-binding; cl15778
517418003321	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
517418003322	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
517418003323	enoyl-CoA hydratase; Provisional; Region: PRK07658
517418003324	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
517418003325	substrate binding site [chemical binding]; other site
517418003326	oxyanion hole (OAH) forming residues; other site
517418003327	trimer interface [polypeptide binding]; other site
517418003328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003329	NAD(P) binding site [chemical binding]; other site
517418003330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003331	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
517418003332	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418003333	ligand binding site [chemical binding]; other site
517418003334	flexible hinge region; other site
517418003335	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
517418003336	putative switch regulator; other site
517418003337	non-specific DNA interactions [nucleotide binding]; other site
517418003338	DNA binding site [nucleotide binding]
517418003339	sequence specific DNA binding site [nucleotide binding]; other site
517418003340	putative cAMP binding site [chemical binding]; other site
517418003341	trigger factor; Region: tig; TIGR00115
517418003342	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
517418003343	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
517418003344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003345	Peptidase family M48; Region: Peptidase_M48; cl12018
517418003346	agmatine deiminase; Region: agmatine_aguA; TIGR03380
517418003347	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
517418003348	hybrid cluster protein; Provisional; Region: PRK05290
517418003349	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517418003350	ACS interaction site; other site
517418003351	CODH interaction site; other site
517418003352	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
517418003353	hybrid metal cluster; other site
517418003354	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
517418003355	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
517418003356	putative catalytic cysteine [active]
517418003357	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
517418003358	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
517418003359	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
517418003360	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
517418003361	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
517418003362	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
517418003363	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
517418003364	thioester formation/cholesterol transfer; other site
517418003365	protein-splicing catalytic site; other site
517418003366	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
517418003367	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
517418003368	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
517418003369	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
517418003370	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
517418003371	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
517418003372	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
517418003373	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
517418003374	TSCPD domain; Region: TSCPD; cl14834
517418003375	Sporulation related domain; Region: SPOR; cl10051
517418003376	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
517418003377	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
517418003378	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003379	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
517418003380	octamerization interface [polypeptide binding]; other site
517418003381	diferric-oxygen binding site [ion binding]; other site
517418003382	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
517418003383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003384	Protein of unknown function (DUF454); Region: DUF454; cl01063
517418003385	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
517418003386	putative acyl-acceptor binding pocket; other site
517418003387	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
517418003388	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418003389	motif II; other site
517418003390	HPr kinase/phosphorylase; Provisional; Region: PRK05428
517418003391	DRTGG domain; Region: DRTGG; cl12147
517418003392	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
517418003393	Hpr binding site; other site
517418003394	active site
517418003395	homohexamer subunit interaction site [polypeptide binding]; other site
517418003396	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
517418003397	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517418003398	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
517418003399	RNA binding surface [nucleotide binding]; other site
517418003400	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
517418003401	active site
517418003402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418003403	binding surface
517418003404	TPR motif; other site
517418003405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418003406	binding surface
517418003407	TPR repeat; Region: TPR_11; pfam13414
517418003408	TPR motif; other site
517418003409	TPR repeat; Region: TPR_11; pfam13414
517418003410	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
517418003411	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418003412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003413	S-adenosylmethionine binding site [chemical binding]; other site
517418003414	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
517418003415	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
517418003416	RNase E interface [polypeptide binding]; other site
517418003417	trimer interface [polypeptide binding]; other site
517418003418	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
517418003419	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
517418003420	RNase E interface [polypeptide binding]; other site
517418003421	trimer interface [polypeptide binding]; other site
517418003422	active site
517418003423	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
517418003424	putative nucleic acid binding region [nucleotide binding]; other site
517418003425	G-X-X-G motif; other site
517418003426	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
517418003427	RNA binding site [nucleotide binding]; other site
517418003428	domain interface; other site
517418003429	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
517418003430	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
517418003431	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
517418003432	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
517418003433	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574
517418003434	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
517418003435	Domain of unknown function DUF21; Region: DUF21; pfam01595
517418003436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
517418003437	Transporter associated domain; Region: CorC_HlyC; cl08393
517418003438	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
517418003439	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
517418003440	dimer interface [polypeptide binding]; other site
517418003441	ssDNA binding site [nucleotide binding]; other site
517418003442	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517418003443	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
517418003444	S17 interaction site [polypeptide binding]; other site
517418003445	S8 interaction site; other site
517418003446	16S rRNA interaction site [nucleotide binding]; other site
517418003447	streptomycin interaction site [chemical binding]; other site
517418003448	23S rRNA interaction site [nucleotide binding]; other site
517418003449	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
517418003450	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
517418003451	elongation factor G; Reviewed; Region: PRK00007
517418003452	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
517418003453	G1 box; other site
517418003454	putative GEF interaction site [polypeptide binding]; other site
517418003455	GTP/Mg2+ binding site [chemical binding]; other site
517418003456	Switch I region; other site
517418003457	G2 box; other site
517418003458	G3 box; other site
517418003459	Switch II region; other site
517418003460	G4 box; other site
517418003461	G5 box; other site
517418003462	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
517418003463	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
517418003464	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
517418003465	elongation factor Tu; Reviewed; Region: PRK00049
517418003466	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
517418003467	G1 box; other site
517418003468	GEF interaction site [polypeptide binding]; other site
517418003469	GTP/Mg2+ binding site [chemical binding]; other site
517418003470	Switch I region; other site
517418003471	G2 box; other site
517418003472	G3 box; other site
517418003473	Switch II region; other site
517418003474	G4 box; other site
517418003475	G5 box; other site
517418003476	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
517418003477	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
517418003478	Antibiotic Binding Site [chemical binding]; other site
517418003479	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
517418003480	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
517418003481	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
517418003482	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
517418003483	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
517418003484	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
517418003485	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
517418003486	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
517418003487	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
517418003488	putative translocon binding site; other site
517418003489	protein-rRNA interface [nucleotide binding]; other site
517418003490	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
517418003491	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
517418003492	G-X-X-G motif; other site
517418003493	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
517418003494	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
517418003495	23S rRNA interface [nucleotide binding]; other site
517418003496	5S rRNA interface [nucleotide binding]; other site
517418003497	putative antibiotic binding site [chemical binding]; other site
517418003498	L25 interface [polypeptide binding]; other site
517418003499	L27 interface [polypeptide binding]; other site
517418003500	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
517418003501	putative translocon interaction site; other site
517418003502	23S rRNA interface [nucleotide binding]; other site
517418003503	signal recognition particle (SRP54) interaction site; other site
517418003504	L23 interface [polypeptide binding]; other site
517418003505	trigger factor interaction site; other site
517418003506	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
517418003507	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
517418003508	KOW motif; Region: KOW; cl00354
517418003509	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
517418003510	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
517418003511	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
517418003512	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
517418003513	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
517418003514	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
517418003515	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
517418003516	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
517418003517	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
517418003518	5S rRNA interface [nucleotide binding]; other site
517418003519	L27 interface [polypeptide binding]; other site
517418003520	23S rRNA interface [nucleotide binding]; other site
517418003521	L5 interface [polypeptide binding]; other site
517418003522	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
517418003523	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
517418003524	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
517418003525	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
517418003526	23S rRNA binding site [nucleotide binding]; other site
517418003527	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
517418003528	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
517418003529	SecY translocase; Region: SecY; pfam00344
517418003530	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
517418003531	rRNA binding site [nucleotide binding]; other site
517418003532	predicted 30S ribosome binding site; other site
517418003533	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
517418003534	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
517418003535	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
517418003536	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
517418003537	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
517418003538	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517418003539	RNA binding surface [nucleotide binding]; other site
517418003540	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
517418003541	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
517418003542	alphaNTD homodimer interface [polypeptide binding]; other site
517418003543	alphaNTD - beta interaction site [polypeptide binding]; other site
517418003544	alphaNTD - beta' interaction site [polypeptide binding]; other site
517418003545	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
517418003546	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
517418003547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418003548	phosphorylation site [posttranslational modification]
517418003549	dimer interface [polypeptide binding]; other site
517418003550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418003551	ATP binding site [chemical binding]; other site
517418003552	Mg2+ binding site [ion binding]; other site
517418003553	G-X-G motif; other site
517418003554	GMP synthase; Reviewed; Region: guaA; PRK00074
517418003555	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
517418003556	AMP/PPi binding site [chemical binding]; other site
517418003557	candidate oxyanion hole; other site
517418003558	catalytic triad [active]
517418003559	potential glutamine specificity residues [chemical binding]; other site
517418003560	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
517418003561	ATP Binding subdomain [chemical binding]; other site
517418003562	Ligand Binding sites [chemical binding]; other site
517418003563	Dimerization subdomain; other site
517418003564	Transglycosylase; Region: Transgly; cl07896
517418003565	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
517418003566	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418003567	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
517418003568	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517418003569	nucleophilic elbow; other site
517418003570	catalytic triad; other site
517418003571	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418003572	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
517418003573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003574	S-adenosylmethionine binding site [chemical binding]; other site
517418003575	transcriptional activator RhaS; Provisional; Region: PRK13503
517418003576	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
517418003577	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418003578	Protein of unknown function, DUF486; Region: DUF486; cl01236
517418003579	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
517418003580	Family description; Region: UvrD_C_2; cl15862
517418003581	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
517418003582	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418003583	active site
517418003584	Prephenate dehydrogenase; Region: PDH; pfam02153
517418003585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003586	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
517418003587	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
517418003588	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
517418003589	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
517418003590	NADP binding site [chemical binding]; other site
517418003591	dimer interface [polypeptide binding]; other site
517418003592	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
517418003593	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418003594	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
517418003595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
517418003596	Survival protein SurE; Region: SurE; cl00448
517418003597	UGMP family protein; Validated; Region: PRK09604
517418003598	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
517418003599	Preprotein translocase subunit; Region: YajC; cl00806
517418003600	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
517418003601	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
517418003602	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
517418003603	catalytic site [active]
517418003604	subunit interface [polypeptide binding]; other site
517418003605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
517418003606	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
517418003607	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
517418003608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003609	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
517418003610	peptide chain release factor 1; Validated; Region: prfA; PRK00591
517418003611	RF-1 domain; Region: RF-1; cl02875
517418003612	RF-1 domain; Region: RF-1; cl02875
517418003613	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
517418003614	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
517418003615	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
517418003616	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003617	G4 box; other site
517418003618	G5 box; other site
517418003619	Acylphosphatase; Region: Acylphosphatase; cl00551
517418003620	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
517418003621	HypF finger; Region: zf-HYPF; pfam07503
517418003622	HypF finger; Region: zf-HYPF; pfam07503
517418003623	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
517418003624	MjaII restriction endonuclease; Region: RE_MjaII; pfam09520
517418003625	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003626	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003627	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
517418003628	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
517418003629	PYR/PP interface [polypeptide binding]; other site
517418003630	dimer interface [polypeptide binding]; other site
517418003631	TPP binding site [chemical binding]; other site
517418003632	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517418003633	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
517418003634	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
517418003635	active site
517418003636	substrate binding site [chemical binding]; other site
517418003637	metal binding site [ion binding]; metal-binding site
517418003638	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
517418003639	recombination protein RecR; Reviewed; Region: recR; PRK00076
517418003640	RecR protein; Region: RecR; pfam02132
517418003641	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
517418003642	putative active site [active]
517418003643	putative metal-binding site [ion binding]; other site
517418003644	tetramer interface [polypeptide binding]; other site
517418003645	phytoene desaturase; Region: phytoene_desat; TIGR02731
517418003646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003647	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
517418003648	Peptidase family U32; Region: Peptidase_U32; cl03113
517418003649	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
517418003650	dimer interface [polypeptide binding]; other site
517418003651	[2Fe-2S] cluster binding site [ion binding]; other site
517418003652	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
517418003653	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
517418003654	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517418003655	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517418003656	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418003657	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418003658	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
517418003659	Helix-turn-helix domains; Region: HTH; cl00088
517418003660	Helix-turn-helix domains; Region: HTH; cl00088
517418003661	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
517418003662	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
517418003663	Predicted ATPase [General function prediction only]; Region: COG3903
517418003664	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418003665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418003666	binding surface
517418003667	TPR motif; other site
517418003668	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418003669	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418003670	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
517418003671	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
517418003672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003673	NAD(P) binding site [chemical binding]; other site
517418003674	active site
517418003675	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
517418003676	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
517418003677	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
517418003678	putative homodimer interface [polypeptide binding]; other site
517418003679	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
517418003680	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
517418003681	23S rRNA interface [nucleotide binding]; other site
517418003682	L7/L12 interface [polypeptide binding]; other site
517418003683	putative thiostrepton binding site; other site
517418003684	L25 interface [polypeptide binding]; other site
517418003685	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
517418003686	mRNA/rRNA interface [nucleotide binding]; other site
517418003687	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
517418003688	23S rRNA interface [nucleotide binding]; other site
517418003689	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
517418003690	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
517418003691	core dimer interface [polypeptide binding]; other site
517418003692	peripheral dimer interface [polypeptide binding]; other site
517418003693	L10 interface [polypeptide binding]; other site
517418003694	L11 interface [polypeptide binding]; other site
517418003695	putative EF-Tu interaction site [polypeptide binding]; other site
517418003696	putative EF-G interaction site [polypeptide binding]; other site
517418003697	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
517418003698	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
517418003699	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
517418003700	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
517418003701	RPB12 interaction site [polypeptide binding]; other site
517418003702	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
517418003703	RPB11 interaction site [polypeptide binding]; other site
517418003704	RPB12 interaction site [polypeptide binding]; other site
517418003705	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
517418003706	RPB12 interaction site [polypeptide binding]; other site
517418003707	RPB3 interaction site [polypeptide binding]; other site
517418003708	RPB1 interaction site [polypeptide binding]; other site
517418003709	RPB11 interaction site [polypeptide binding]; other site
517418003710	RPB10 interaction site [polypeptide binding]; other site
517418003711	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
517418003712	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
517418003713	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
517418003714	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
517418003715	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
517418003716	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
517418003717	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
517418003718	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
517418003719	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
517418003720	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
517418003721	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
517418003722	DNA binding site [nucleotide binding]
517418003723	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
517418003724	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
517418003725	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418003726	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418003727	Zn binding site [ion binding]; other site
517418003728	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
517418003729	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418003730	spermidine synthase; Provisional; Region: PRK03612
517418003731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003732	Predicted membrane protein [Function unknown]; Region: COG3766
517418003733	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
517418003734	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
517418003735	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
517418003736	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
517418003737	Low molecular weight phosphatase family; Region: LMWPc; cd00115
517418003738	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
517418003739	active site
517418003740	Predicted permeases [General function prediction only]; Region: COG0701
517418003741	Predicted permease; Region: DUF318; pfam03773
517418003742	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
517418003743	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517418003744	dimerization interface [polypeptide binding]; other site
517418003745	putative DNA binding site [nucleotide binding]; other site
517418003746	putative Zn2+ binding site [ion binding]; other site
517418003747	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
517418003748	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517418003749	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517418003750	DNA binding residues [nucleotide binding]
517418003751	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
517418003752	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
517418003753	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
517418003754	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
517418003755	active site
517418003756	aspartate aminotransferase; Provisional; Region: PRK05764
517418003757	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517418003758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418003759	homodimer interface [polypeptide binding]; other site
517418003760	catalytic residue [active]
517418003761	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
517418003762	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
517418003763	active site
517418003764	(T/H)XGH motif; other site
517418003765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003766	S-adenosylmethionine binding site [chemical binding]; other site
517418003767	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
517418003768	TPP-binding site [chemical binding]; other site
517418003769	dimer interface [polypeptide binding]; other site
517418003770	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
517418003771	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
517418003772	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
517418003773	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
517418003774	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
517418003775	ATP binding site [chemical binding]; other site
517418003776	active site
517418003777	substrate binding site [chemical binding]; other site
517418003778	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
517418003779	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
517418003780	homodimer interface [polypeptide binding]; other site
517418003781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418003782	catalytic residue [active]
517418003783	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
517418003784	nudix motif; other site
517418003785	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
517418003786	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517418003787	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418003788	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
517418003789	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
517418003790	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
517418003791	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517418003792	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418003793	14-3-3 domain; Region: 14-3-3; cl02098
517418003794	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418003795	Helix-turn-helix domains; Region: HTH; cl00088
517418003796	WHG domain; Region: WHG; pfam13305
517418003797	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
517418003798	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
517418003799	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
517418003800	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
517418003801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418003802	catalytic residue [active]
517418003803	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
517418003804	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
517418003805	GTP binding site; other site
517418003806	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
517418003807	Walker A motif; other site
517418003808	Integral membrane protein TerC family; Region: TerC; cl10468
517418003809	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
517418003810	putative YPXnL-motif binding site; other site
517418003811	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
517418003812	MjaI restriction endonuclease; Region: RE_MjaI; pfam09568
517418003813	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
517418003814	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
517418003815	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
517418003816	active site
517418003817	(T/H)XGH motif; other site
517418003818	SdiA-regulated; Region: SdiA-regulated; cd09971
517418003819	putative active site [active]
517418003820	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
517418003821	thiamine monophosphate kinase; Provisional; Region: PRK05731
517418003822	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
517418003823	ATP binding site [chemical binding]; other site
517418003824	dimerization interface [polypeptide binding]; other site
517418003825	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
517418003826	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
517418003827	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
517418003828	P loop; other site
517418003829	GTP binding site [chemical binding]; other site
517418003830	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
517418003831	intersubunit interface [polypeptide binding]; other site
517418003832	active site
517418003833	catalytic residue [active]
517418003834	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
517418003835	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003836	Walker A/P-loop; other site
517418003837	ATP binding site [chemical binding]; other site
517418003838	Q-loop/lid; other site
517418003839	ABC transporter signature motif; other site
517418003840	Walker B; other site
517418003841	D-loop; other site
517418003842	H-loop/switch region; other site
517418003843	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
517418003844	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
517418003845	RNA binding site [nucleotide binding]; other site
517418003846	active site
517418003847	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
517418003848	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
517418003849	active site
517418003850	Riboflavin kinase; Region: Flavokinase; cl03312
517418003851	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
517418003852	16S/18S rRNA binding site [nucleotide binding]; other site
517418003853	S13e-L30e interaction site [polypeptide binding]; other site
517418003854	25S rRNA binding site [nucleotide binding]; other site
517418003855	Thymidylate synthase complementing protein; Region: Thy1; cl03630
517418003856	excinuclease ABC subunit B; Provisional; Region: PRK05298
517418003857	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517418003858	ATP binding site [chemical binding]; other site
517418003859	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418003860	nucleotide binding region [chemical binding]; other site
517418003861	ATP-binding site [chemical binding]; other site
517418003862	Ultra-violet resistance protein B; Region: UvrB; pfam12344
517418003863	UvrB/uvrC motif; Region: UVR; pfam02151
517418003864	Peptidase family M23; Region: Peptidase_M23; pfam01551
517418003865	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
517418003866	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
517418003867	Surface antigen; Region: Bac_surface_Ag; cl03097
517418003868	Oxygen tolerance; Region: BatD; pfam13584
517418003869	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
517418003870	Radical SAM superfamily; Region: Radical_SAM; pfam04055
517418003871	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
517418003872	LPP20 lipoprotein; Region: LPP20; cl15824
517418003873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
517418003874	TolB amino-terminal domain; Region: TolB_N; cl00639
517418003875	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
517418003876	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
517418003877	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
517418003878	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
517418003879	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
517418003880	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418003881	active site
517418003882	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
517418003883	DinB superfamily; Region: DinB_2; pfam12867
517418003884	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517418003885	catalytic loop [active]
517418003886	iron binding site [ion binding]; other site
517418003887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517418003888	catalytic loop [active]
517418003889	iron binding site [ion binding]; other site
517418003890	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
517418003891	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
517418003892	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517418003893	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
517418003894	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
517418003895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003896	carotene isomerase; Region: carot_isom; TIGR02730
517418003897	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
517418003898	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517418003899	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517418003900	DNA binding residues [nucleotide binding]
517418003901	Putative zinc-finger; Region: zf-HC2; cl15806
517418003902	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517418003903	dimerization interface [polypeptide binding]; other site
517418003904	putative DNA binding site [nucleotide binding]; other site
517418003905	putative Zn2+ binding site [ion binding]; other site
517418003906	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
517418003907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003908	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418003909	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
517418003910	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
517418003911	putative dimer interface [polypeptide binding]; other site
517418003912	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
517418003913	Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
517418003914	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
517418003915	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
517418003916	NADP binding site [chemical binding]; other site
517418003917	active site
517418003918	putative substrate binding site [chemical binding]; other site
517418003919	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
517418003920	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
517418003921	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
517418003922	putative substrate-binding site; other site
517418003923	nickel binding site [ion binding]; other site
517418003924	CobD/Cbib protein; Region: CobD_Cbib; cl00561
517418003925	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
517418003926	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517418003927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418003928	homodimer interface [polypeptide binding]; other site
517418003929	catalytic residue [active]
517418003930	Cupin domain; Region: Cupin_2; cl09118
517418003931	cobyric acid synthase; Provisional; Region: PRK00784
517418003932	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003933	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003934	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
517418003935	catalytic triad [active]
517418003936	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
517418003937	Predicted ATPase [General function prediction only]; Region: COG4637
517418003938	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003939	Walker A/P-loop; other site
517418003940	ATP binding site [chemical binding]; other site
517418003941	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
517418003942	Walker B; other site
517418003943	D-loop; other site
517418003944	H-loop/switch region; other site
517418003945	16S rRNA methyltransferase B; Provisional; Region: PRK14904
517418003946	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
517418003947	putative RNA binding site [nucleotide binding]; other site
517418003948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
517418003949	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
517418003950	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
517418003951	homodimer interface [polypeptide binding]; other site
517418003952	substrate-cofactor binding pocket; other site
517418003953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418003954	catalytic residue [active]
517418003955	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418003956	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
517418003957	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247
517418003958	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003959	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
517418003960	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418003961	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003962	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
517418003963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418003964	S-adenosylmethionine binding site [chemical binding]; other site
517418003965	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003966	magnesium chelatase subunit H; Provisional; Region: PRK12493
517418003967	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
517418003968	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418003969	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418003970	magnesium chelatase, H subunit; Region: BchH; TIGR02025
517418003971	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
517418003972	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418003973	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418003974	Uncharacterized ArCR, COG2043; Region: DUF169; cl00894
517418003975	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418003976	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
517418003977	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418003978	N-terminal plug; other site
517418003979	ligand-binding site [chemical binding]; other site
517418003980	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517418003981	B12 binding site [chemical binding]; other site
517418003982	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
517418003983	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
517418003984	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517418003985	putative catalytic site [active]
517418003986	putative metal binding site [ion binding]; other site
517418003987	putative phosphate binding site [ion binding]; other site
517418003988	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418003989	structural tetrad; other site
517418003990	FOG: WD40 repeat [General function prediction only]; Region: COG2319
517418003991	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418003992	structural tetrad; other site
517418003993	AAA domain; Region: AAA_28; pfam13521
517418003994	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418003995	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
517418003996	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419
517418003997	Ion channel; Region: Ion_trans_2; cl11596
517418003998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418003999	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418004000	ligand binding site [chemical binding]; other site
517418004001	flexible hinge region; other site
517418004002	dihydroorotase; Validated; Region: pyrC; PRK09357
517418004003	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
517418004004	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
517418004005	active site
517418004006	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
517418004007	metal binding site 2 [ion binding]; metal-binding site
517418004008	putative DNA binding helix; other site
517418004009	metal binding site 1 [ion binding]; metal-binding site
517418004010	dimer interface [polypeptide binding]; other site
517418004011	structural Zn2+ binding site [ion binding]; other site
517418004012	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
517418004013	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
517418004014	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
517418004015	dimerization interface [polypeptide binding]; other site
517418004016	active site
517418004017	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
517418004018	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
517418004019	active site
517418004020	NTP binding site [chemical binding]; other site
517418004021	metal binding triad [ion binding]; metal-binding site
517418004022	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
517418004023	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418004024	Zn2+ binding site [ion binding]; other site
517418004025	Mg2+ binding site [ion binding]; other site
517418004026	ribonuclease E; Reviewed; Region: rne; PRK10811
517418004027	EamA-like transporter family; Region: EamA; cl01037
517418004028	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517418004029	putative catalytic site [active]
517418004030	putative metal binding site [ion binding]; other site
517418004031	putative phosphate binding site [ion binding]; other site
517418004032	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
517418004033	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
517418004034	homodimer interface [polypeptide binding]; other site
517418004035	active site pocket [active]
517418004036	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
517418004037	TIR domain; Region: TIR_2; cl15770
517418004038	NB-ARC domain; Region: NB-ARC; pfam00931
517418004039	Tetratricopeptide repeat; Region: TPR_10; pfam13374
517418004040	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004041	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004042	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418004043	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004044	TPR motif; other site
517418004045	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004046	binding surface
517418004047	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
517418004048	ABC-2 type transporter; Region: ABC2_membrane; cl11417
517418004049	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
517418004050	ABC-2 type transporter; Region: ABC2_membrane; cl11417
517418004051	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
517418004052	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418004053	Walker A/P-loop; other site
517418004054	ATP binding site [chemical binding]; other site
517418004055	Q-loop/lid; other site
517418004056	ABC transporter signature motif; other site
517418004057	Walker B; other site
517418004058	D-loop; other site
517418004059	H-loop/switch region; other site
517418004060	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
517418004061	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
517418004062	Walker A/P-loop; other site
517418004063	ATP binding site [chemical binding]; other site
517418004064	Q-loop/lid; other site
517418004065	ABC transporter signature motif; other site
517418004066	Walker B; other site
517418004067	D-loop; other site
517418004068	H-loop/switch region; other site
517418004069	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
517418004070	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
517418004071	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418004072	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517418004073	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
517418004074	Helix-turn-helix domains; Region: HTH; cl00088
517418004075	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418004076	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
517418004077	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
517418004078	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
517418004079	RNA/DNA hybrid binding site [nucleotide binding]; other site
517418004080	active site
517418004081	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
517418004082	catalytic triad [active]
517418004083	GTP-binding protein Der; Reviewed; Region: PRK00093
517418004084	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
517418004085	G1 box; other site
517418004086	GTP/Mg2+ binding site [chemical binding]; other site
517418004087	Switch I region; other site
517418004088	G2 box; other site
517418004089	Switch II region; other site
517418004090	G3 box; other site
517418004091	G4 box; other site
517418004092	G5 box; other site
517418004093	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
517418004094	G1 box; other site
517418004095	GTP/Mg2+ binding site [chemical binding]; other site
517418004096	Switch I region; other site
517418004097	G2 box; other site
517418004098	G3 box; other site
517418004099	Switch II region; other site
517418004100	G4 box; other site
517418004101	G5 box; other site
517418004102	antiporter inner membrane protein; Provisional; Region: PRK11670
517418004103	Domain of unknown function DUF59; Region: DUF59; cl00941
517418004104	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
517418004105	Walker A motif; other site
517418004106	NifU-like domain; Region: NifU; cl00484
517418004107	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
517418004108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418004109	dimer interface [polypeptide binding]; other site
517418004110	conserved gate region; other site
517418004111	putative PBP binding loops; other site
517418004112	ABC-ATPase subunit interface; other site
517418004113	membrane ATPase/protein kinase; Provisional; Region: PRK09435
517418004114	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418004115	GTP/Mg2+ binding site [chemical binding]; other site
517418004116	G5 box; other site
517418004117	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
517418004118	Walker A; other site
517418004119	G1 box; other site
517418004120	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
517418004121	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
517418004122	peptide chain release factor 2; Validated; Region: prfB; PRK00578
517418004123	RF-1 domain; Region: RF-1; cl02875
517418004124	RF-1 domain; Region: RF-1; cl02875
517418004125	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
517418004126	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517418004127	minor groove reading motif; other site
517418004128	helix-hairpin-helix signature motif; other site
517418004129	substrate binding pocket [chemical binding]; other site
517418004130	active site
517418004131	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
517418004132	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
517418004133	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
517418004134	active site
517418004135	metal binding site [ion binding]; metal-binding site
517418004136	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
517418004137	dihydropteroate synthase; Region: DHPS; TIGR01496
517418004138	substrate binding pocket [chemical binding]; other site
517418004139	dimer interface [polypeptide binding]; other site
517418004140	inhibitor binding site; inhibition site
517418004141	Uncharacterized conserved protein [Function unknown]; Region: COG1624
517418004142	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
517418004143	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
517418004144	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
517418004145	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
517418004146	ABC transporter; Region: ABC_tran_2; pfam12848
517418004147	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
517418004148	peptide chain release factor 2; Validated; Region: prfB; PRK00578
517418004149	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
517418004150	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
517418004151	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
517418004152	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
517418004153	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
517418004154	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
517418004155	aspartate kinase III; Validated; Region: PRK09084
517418004156	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
517418004157	nucleotide binding site [chemical binding]; other site
517418004158	substrate binding site [chemical binding]; other site
517418004159	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
517418004160	dimer interface [polypeptide binding]; other site
517418004161	allosteric regulatory binding pocket; other site
517418004162	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
517418004163	Response regulator receiver domain; Region: Response_reg; pfam00072
517418004164	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418004165	active site
517418004166	phosphorylation site [posttranslational modification]
517418004167	intermolecular recognition site; other site
517418004168	dimerization interface [polypeptide binding]; other site
517418004169	PglZ domain; Region: PglZ; pfam08665
517418004170	Cupin domain; Region: Cupin_2; cl09118
517418004171	KWG Leptospira; Region: KWG; pfam07656
517418004172	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
517418004173	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
517418004174	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517418004175	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
517418004176	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
517418004177	trimer interface [polypeptide binding]; other site
517418004178	active site
517418004179	substrate binding site [chemical binding]; other site
517418004180	CoA binding site [chemical binding]; other site
517418004181	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
517418004182	MoaE interaction surface [polypeptide binding]; other site
517418004183	MoeB interaction surface [polypeptide binding]; other site
517418004184	thiocarboxylated glycine; other site
517418004185	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
517418004186	MoaE homodimer interface [polypeptide binding]; other site
517418004187	MoaD interaction [polypeptide binding]; other site
517418004188	active site residues [active]
517418004189	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
517418004190	putative active site pocket [active]
517418004191	dimerization interface [polypeptide binding]; other site
517418004192	putative catalytic residue [active]
517418004193	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
517418004194	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
517418004195	hinge; other site
517418004196	active site
517418004197	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
517418004198	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
517418004199	active site clefts [active]
517418004200	zinc binding site [ion binding]; other site
517418004201	dimer interface [polypeptide binding]; other site
517418004202	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
517418004203	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
517418004204	putative catalytic residues [active]
517418004205	putative nucleotide binding site [chemical binding]; other site
517418004206	putative aspartate binding site [chemical binding]; other site
517418004207	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
517418004208	dimer interface [polypeptide binding]; other site
517418004209	putative threonine allosteric regulatory site; other site
517418004210	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
517418004211	putative threonine allosteric regulatory site; other site
517418004212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418004213	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
517418004214	YtxH-like protein; Region: YtxH; cl02079
517418004215	Acylphosphatase; Region: Acylphosphatase; cl00551
517418004216	FtsH Extracellular; Region: FtsH_ext; pfam06480
517418004217	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
517418004218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418004219	Walker B motif; other site
517418004220	arginine finger; other site
517418004221	Peptidase family M41; Region: Peptidase_M41; pfam01434
517418004222	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
517418004223	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
517418004224	active site
517418004225	ribulose/triose binding site [chemical binding]; other site
517418004226	phosphate binding site [ion binding]; other site
517418004227	substrate (anthranilate) binding pocket [chemical binding]; other site
517418004228	product (indole) binding pocket [chemical binding]; other site
517418004229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418004230	binding surface
517418004231	TPR motif; other site
517418004232	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004233	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418004235	binding surface
517418004236	TPR motif; other site
517418004237	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418004239	binding surface
517418004240	TPR motif; other site
517418004241	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004242	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004243	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004245	binding surface
517418004246	TPR motif; other site
517418004247	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004248	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004249	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
517418004250	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
517418004251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418004252	dimer interface [polypeptide binding]; other site
517418004253	conserved gate region; other site
517418004254	putative PBP binding loops; other site
517418004255	ABC-ATPase subunit interface; other site
517418004256	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
517418004257	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
517418004258	P-loop; other site
517418004259	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
517418004260	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
517418004261	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
517418004262	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517418004263	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
517418004264	Peptidase family M23; Region: Peptidase_M23; pfam01551
517418004265	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
517418004266	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
517418004267	ATP synthase A chain; Region: ATP-synt_A; cl00413
517418004268	Plant ATP synthase F0; Region: YMF19; cl07975
517418004269	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
517418004270	Plant ATP synthase F0; Region: YMF19; cl07975
517418004271	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
517418004272	Restriction endonuclease; Region: Mrr_cat; cl00516
517418004273	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
517418004274	RNA/DNA hybrid binding site [nucleotide binding]; other site
517418004275	active site
517418004276	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
517418004277	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
517418004278	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
517418004279	putative NAD(P) binding site [chemical binding]; other site
517418004280	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
517418004281	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
517418004282	Walker A/P-loop; other site
517418004283	ATP binding site [chemical binding]; other site
517418004284	Q-loop/lid; other site
517418004285	ABC transporter signature motif; other site
517418004286	Walker B; other site
517418004287	D-loop; other site
517418004288	H-loop/switch region; other site
517418004289	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
517418004290	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004291	binding surface
517418004292	TPR motif; other site
517418004293	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004295	binding surface
517418004296	TPR motif; other site
517418004297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004298	binding surface
517418004299	TPR motif; other site
517418004300	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418004301	ligand binding site [chemical binding]; other site
517418004302	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
517418004303	active site
517418004304	ADP/pyrophosphate binding site [chemical binding]; other site
517418004305	dimerization interface [polypeptide binding]; other site
517418004306	allosteric effector site; other site
517418004307	fructose-1,6-bisphosphate binding site; other site
517418004308	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
517418004309	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
517418004310	active site
517418004311	substrate-binding site [chemical binding]; other site
517418004312	metal-binding site [ion binding]
517418004313	GTP binding site [chemical binding]; other site
517418004314	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418004315	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
517418004316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004318	binding surface
517418004319	TPR motif; other site
517418004320	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004322	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004323	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004324	binding surface
517418004325	TPR motif; other site
517418004326	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004327	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004328	binding surface
517418004329	TPR motif; other site
517418004330	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004331	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
517418004332	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517418004333	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517418004334	DNA binding residues [nucleotide binding]
517418004335	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
517418004336	Ferritin-like domain; Region: Ferritin; pfam00210
517418004337	diiron binding motif [ion binding]; other site
517418004338	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
517418004339	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
517418004340	FAD binding pocket [chemical binding]; other site
517418004341	FAD binding motif [chemical binding]; other site
517418004342	phosphate binding motif [ion binding]; other site
517418004343	beta-alpha-beta structure motif; other site
517418004344	NAD binding pocket [chemical binding]; other site
517418004345	Iron coordination center [ion binding]; other site
517418004346	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
517418004347	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
517418004348	catalytic residues [active]
517418004349	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
517418004350	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
517418004351	putative active site [active]
517418004352	oxyanion strand; other site
517418004353	catalytic triad [active]
517418004354	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
517418004355	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
517418004356	catalytic residues [active]
517418004357	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
517418004358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517418004359	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
517418004360	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418004361	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
517418004362	IMP binding site; other site
517418004363	dimer interface [polypeptide binding]; other site
517418004364	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418004365	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418004366	Walker A/P-loop; other site
517418004367	ATP binding site [chemical binding]; other site
517418004368	Q-loop/lid; other site
517418004369	ABC transporter signature motif; other site
517418004370	Walker B; other site
517418004371	D-loop; other site
517418004372	H-loop/switch region; other site
517418004373	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517418004374	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418004375	FtsX-like permease family; Region: FtsX; cl15850
517418004376	Motility related/secretion protein; Region: SprA_N; pfam14349
517418004377	Motility related/secretion protein; Region: SprA_N; pfam14349
517418004378	Motility related/secretion protein; Region: SprA_N; pfam14349
517418004379	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
517418004380	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
517418004381	GIY-YIG motif/motif A; other site
517418004382	active site
517418004383	catalytic site [active]
517418004384	putative DNA binding site [nucleotide binding]; other site
517418004385	metal binding site [ion binding]; metal-binding site
517418004386	UvrB/uvrC motif; Region: UVR; pfam02151
517418004387	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
517418004388	Predicted amidohydrolase [General function prediction only]; Region: COG0388
517418004389	Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577
517418004390	putative active site [active]
517418004391	catalytic triad [active]
517418004392	putative tetramer interface [polypeptide binding]; other site
517418004393	dimer interface [polypeptide binding]; other site
517418004394	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
517418004395	elongation factor G; Reviewed; Region: PRK12740
517418004396	G1 box; other site
517418004397	putative GEF interaction site [polypeptide binding]; other site
517418004398	GTP/Mg2+ binding site [chemical binding]; other site
517418004399	Switch I region; other site
517418004400	G2 box; other site
517418004401	G3 box; other site
517418004402	Switch II region; other site
517418004403	G4 box; other site
517418004404	G5 box; other site
517418004405	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
517418004406	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
517418004407	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
517418004408	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517418004409	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
517418004410	Ligand binding site; other site
517418004411	Putative Catalytic site; other site
517418004412	DXD motif; other site
517418004413	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
517418004414	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
517418004415	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
517418004416	DNA binding residues [nucleotide binding]
517418004417	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
517418004418	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517418004419	B12 binding site [chemical binding]; other site
517418004420	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
517418004421	active site
517418004422	intersubunit interactions; other site
517418004423	catalytic residue [active]
517418004424	Deoxyhypusine synthase; Region: DS; cl00826
517418004425	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
517418004426	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
517418004427	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
517418004428	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
517418004429	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
517418004430	TM-ABC transporter signature motif; other site
517418004431	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
517418004432	Phage Tail Collar Domain; Region: Collar; pfam07484
517418004433	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
517418004434	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418004435	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
517418004436	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
517418004437	Ligand Binding Site [chemical binding]; other site
517418004438	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
517418004439	nucleophile elbow; other site
517418004440	Surface antigen; Region: Bac_surface_Ag; cl03097
517418004441	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
517418004442	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
517418004443	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
517418004444	TPR repeat; Region: TPR_11; pfam13414
517418004445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004446	TPR motif; other site
517418004447	binding surface
517418004448	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
517418004449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004450	binding surface
517418004451	TPR motif; other site
517418004452	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517418004453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004454	binding surface
517418004455	TPR motif; other site
517418004456	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418004457	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004458	binding surface
517418004459	TPR repeat; Region: TPR_11; pfam13414
517418004460	TPR motif; other site
517418004461	TPR repeat; Region: TPR_11; pfam13414
517418004462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418004463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418004464	dimer interface [polypeptide binding]; other site
517418004465	conserved gate region; other site
517418004466	putative PBP binding loops; other site
517418004467	ABC-ATPase subunit interface; other site
517418004468	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
517418004469	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418004470	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
517418004471	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
517418004472	HIGH motif; other site
517418004473	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
517418004474	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517418004475	active site
517418004476	KMSKS motif; other site
517418004477	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
517418004478	tRNA binding surface [nucleotide binding]; other site
517418004479	YcfA-like protein; Region: YcfA; cl00752
517418004480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418004481	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
517418004482	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517418004483	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
517418004484	inhibitor-cofactor binding pocket; inhibition site
517418004485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418004486	catalytic residue [active]
517418004487	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
517418004488	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
517418004489	putative substrate binding site [chemical binding]; other site
517418004490	putative ATP binding site [chemical binding]; other site
517418004491	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
517418004492	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
517418004493	active site
517418004494	multimer interface [polypeptide binding]; other site
517418004495	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418004496	active site
517418004497	gamma-glutamyl kinase; Provisional; Region: PRK05429
517418004498	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
517418004499	nucleotide binding site [chemical binding]; other site
517418004500	homotetrameric interface [polypeptide binding]; other site
517418004501	putative phosphate binding site [ion binding]; other site
517418004502	putative allosteric binding site; other site
517418004503	PUA domain; Region: PUA; cl00607
517418004504	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
517418004505	aspartate racemase; Region: asp_race; TIGR00035
517418004506	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
517418004507	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
517418004508	Transposase [DNA replication, recombination, and repair]; Region: COG5433
517418004509	Transposase [DNA replication, recombination, and repair]; Region: COG5433
517418004510	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
517418004511	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
517418004512	Protein export membrane protein; Region: SecD_SecF; cl14618
517418004513	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
517418004514	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
517418004515	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
517418004516	putative catalytic cysteine [active]
517418004517	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418004518	Zn2+ binding site [ion binding]; other site
517418004519	Mg2+ binding site [ion binding]; other site
517418004520	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418004521	Zn2+ binding site [ion binding]; other site
517418004522	Mg2+ binding site [ion binding]; other site
517418004523	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
517418004524	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
517418004525	nudix motif; other site
517418004526	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
517418004527	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
517418004528	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
517418004529	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
517418004530	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
517418004531	active site
517418004532	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
517418004533	Double zinc ribbon; Region: DZR; pfam12773
517418004534	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
517418004535	TPR repeat; Region: TPR_11; pfam13414
517418004536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418004537	binding surface
517418004538	TPR repeat; Region: TPR_11; pfam13414
517418004539	TPR motif; other site
517418004540	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
517418004541	IHF dimer interface [polypeptide binding]; other site
517418004542	IHF - DNA interface [nucleotide binding]; other site
517418004543	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
517418004544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418004545	Walker B motif; other site
517418004546	arginine finger; other site
517418004547	Peptidase family M41; Region: Peptidase_M41; pfam01434
517418004548	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418004549	active site
517418004550	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
517418004551	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
517418004552	MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1.  In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249
517418004553	Walker A/P-loop; other site
517418004554	ATP binding site [chemical binding]; other site
517418004555	Q-loop/lid; other site
517418004556	ABC transporter signature motif; other site
517418004557	Walker B; other site
517418004558	D-loop; other site
517418004559	H-loop/switch region; other site
517418004560	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418004561	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
517418004562	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517418004563	Surface antigen; Region: Bac_surface_Ag; cl03097
517418004564	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
517418004565	spermidine synthase; Provisional; Region: PRK00811
517418004566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418004567	S-adenosylmethionine binding site [chemical binding]; other site
517418004568	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
517418004569	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
517418004570	catalytic triad [active]
517418004571	ABC-2 type transporter; Region: ABC2_membrane; cl11417
517418004572	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
517418004573	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
517418004574	Walker A/P-loop; other site
517418004575	ATP binding site [chemical binding]; other site
517418004576	Q-loop/lid; other site
517418004577	ABC transporter signature motif; other site
517418004578	Walker B; other site
517418004579	D-loop; other site
517418004580	H-loop/switch region; other site
517418004581	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418004582	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
517418004583	mce related protein; Region: MCE; pfam02470
517418004584	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
517418004585	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
517418004586	Int/Topo IB signature motif; other site
517418004587	active site
517418004588	Motility related/secretion protein; Region: SprA_N; pfam14349
517418004589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
517418004590	dimerization interface [polypeptide binding]; other site
517418004591	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
517418004592	cyclase homology domain; Region: CHD; cd07302
517418004593	nucleotidyl binding site; other site
517418004594	metal binding site [ion binding]; metal-binding site
517418004595	dimer interface [polypeptide binding]; other site
517418004596	Helix-turn-helix domains; Region: HTH; cl00088
517418004597	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
517418004598	TOBE domain; Region: TOBE_2; cl01440
517418004599	TOBE domain; Region: TOBE_2; cl01440
517418004600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418004601	PAS fold; Region: PAS_3; pfam08447
517418004602	putative active site [active]
517418004603	heme pocket [chemical binding]; other site
517418004604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418004605	dimer interface [polypeptide binding]; other site
517418004606	phosphorylation site [posttranslational modification]
517418004607	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
517418004608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418004609	ATP binding site [chemical binding]; other site
517418004610	G-X-G motif; other site
517418004611	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418004612	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
517418004613	oligomerisation interface [polypeptide binding]; other site
517418004614	mobile loop; other site
517418004615	roof hairpin; other site
517418004616	Quinolinate synthetase A protein; Region: NadA; cl00420
517418004617	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
517418004618	putative active site pocket [active]
517418004619	dimerization interface [polypeptide binding]; other site
517418004620	putative catalytic residue [active]
517418004621	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
517418004622	Domain of unknown function (DUF368); Region: DUF368; cl00893
517418004623	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
517418004624	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
517418004625	TPP-binding site [chemical binding]; other site
517418004626	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
517418004627	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
517418004628	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
517418004629	dimer interface [polypeptide binding]; other site
517418004630	PYR/PP interface [polypeptide binding]; other site
517418004631	TPP binding site [chemical binding]; other site
517418004632	substrate binding site [chemical binding]; other site
517418004633	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517418004634	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418004635	P loop; other site
517418004636	Nucleotide binding site [chemical binding]; other site
517418004637	DTAP/Switch II; other site
517418004638	Switch I; other site
517418004639	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
517418004640	Ligand Binding Site [chemical binding]; other site
517418004641	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
517418004642	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
517418004643	active site
517418004644	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517418004645	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
517418004646	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418004647	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
517418004648	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
517418004649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
517418004650	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
517418004651	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
517418004652	acetylornithine aminotransferase; Provisional; Region: PRK02627
517418004653	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
517418004654	inhibitor-cofactor binding pocket; inhibition site
517418004655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418004656	catalytic residue [active]
517418004657	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517418004658	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
517418004659	A new structural DNA glycosylase; Region: AlkD_like; cd06561
517418004660	active site
517418004661	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
517418004662	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
517418004663	dimer interface [polypeptide binding]; other site
517418004664	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418004665	catalytic residue [active]
517418004666	Family description; Region: VCBS; pfam13517
517418004667	Family description; Region: VCBS; pfam13517
517418004668	Family description; Region: VCBS; pfam13517
517418004669	Family description; Region: VCBS; pfam13517
517418004670	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
517418004671	active site
517418004672	catalytic residues [active]
517418004673	metal binding site [ion binding]; metal-binding site
517418004674	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
517418004675	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
517418004676	putative active site [active]
517418004677	substrate binding site [chemical binding]; other site
517418004678	putative cosubstrate binding site; other site
517418004679	catalytic site [active]
517418004680	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
517418004681	substrate binding site [chemical binding]; other site
517418004682	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517418004683	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
517418004684	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517418004685	catalytic residues [active]
517418004686	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
517418004687	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
517418004688	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
517418004689	putative tRNA-binding site [nucleotide binding]; other site
517418004690	B3/4 domain; Region: B3_4; cl11458
517418004691	tRNA synthetase B5 domain; Region: B5; cl08394
517418004692	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
517418004693	dimer interface [polypeptide binding]; other site
517418004694	motif 1; other site
517418004695	motif 3; other site
517418004696	motif 2; other site
517418004697	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
517418004698	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
517418004699	Cell division protein ZapA; Region: ZapA; cl01146
517418004700	phosphodiesterase; Provisional; Region: PRK12704
517418004701	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
517418004702	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
517418004703	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
517418004704	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
517418004705	GDP-binding site [chemical binding]; other site
517418004706	ACT binding site; other site
517418004707	IMP binding site; other site
517418004708	Predicted GTPase [General function prediction only]; Region: COG0218
517418004709	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
517418004710	G1 box; other site
517418004711	GTP/Mg2+ binding site [chemical binding]; other site
517418004712	Switch I region; other site
517418004713	G2 box; other site
517418004714	G3 box; other site
517418004715	Switch II region; other site
517418004716	G4 box; other site
517418004717	G5 box; other site
517418004718	Domain of unknown function (DUF309); Region: DUF309; cl00667
517418004719	Septum formation initiator; Region: DivIC; cl11433
517418004720	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
517418004721	1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821
517418004722	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
517418004723	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
517418004724	putative acyl-acceptor binding pocket; other site
517418004725	YceI-like domain; Region: YceI; cl01001
517418004726	adenylate kinase; Reviewed; Region: adk; PRK00279
517418004727	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
517418004728	AMP-binding site [chemical binding]; other site
517418004729	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
517418004730	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
517418004731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418004732	FeS/SAM binding site; other site
517418004733	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
517418004734	active site
517418004735	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
517418004736	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
517418004737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418004738	dimer interface [polypeptide binding]; other site
517418004739	phosphorylation site [posttranslational modification]
517418004740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418004741	ATP binding site [chemical binding]; other site
517418004742	Mg2+ binding site [ion binding]; other site
517418004743	G-X-G motif; other site
517418004744	FecR protein; Region: FecR; pfam04773
517418004745	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
517418004746	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
517418004747	polycystin cation channel protein; Region: PCC; TIGR00864
517418004748	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
517418004749	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
517418004750	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
517418004751	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
517418004752	16S rRNA methyltransferase B; Provisional; Region: PRK14901
517418004753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
517418004754	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
517418004755	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418004756	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
517418004757	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418004758	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
517418004759	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517418004760	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
517418004761	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
517418004762	Walker A/P-loop; other site
517418004763	ATP binding site [chemical binding]; other site
517418004764	Q-loop/lid; other site
517418004765	ABC transporter signature motif; other site
517418004766	Walker B; other site
517418004767	D-loop; other site
517418004768	H-loop/switch region; other site
517418004769	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
517418004770	Hexamer/Pentamer interface [polypeptide binding]; other site
517418004771	central pore; other site
517418004772	The GLUG motif; Region: Glug; pfam07581
517418004773	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418004774	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418004775	GTPase RsgA; Reviewed; Region: PRK00098
517418004776	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517418004777	RNA binding site [nucleotide binding]; other site
517418004778	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
517418004779	GTPase/Zn-binding domain interface [polypeptide binding]; other site
517418004780	GTP/Mg2+ binding site [chemical binding]; other site
517418004781	G4 box; other site
517418004782	G5 box; other site
517418004783	G1 box; other site
517418004784	Switch I region; other site
517418004785	G2 box; other site
517418004786	G3 box; other site
517418004787	Switch II region; other site
517418004788	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
517418004789	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
517418004790	generic binding surface II; other site
517418004791	ssDNA binding site; other site
517418004792	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517418004793	ATP binding site [chemical binding]; other site
517418004794	putative Mg++ binding site [ion binding]; other site
517418004795	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418004796	nucleotide binding region [chemical binding]; other site
517418004797	ATP-binding site [chemical binding]; other site
517418004798	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
517418004799	ribosome recycling factor; Reviewed; Region: frr; PRK00083
517418004800	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
517418004801	hinge region; other site
517418004802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418004803	PAS domain; Region: PAS_9; pfam13426
517418004804	PAS fold; Region: PAS_4; pfam08448
517418004805	PAS domain S-box; Region: sensory_box; TIGR00229
517418004806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418004807	putative active site [active]
517418004808	heme pocket [chemical binding]; other site
517418004809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418004810	PAS domain; Region: PAS_9; pfam13426
517418004811	putative active site [active]
517418004812	heme pocket [chemical binding]; other site
517418004813	GAF domain; Region: GAF_2; pfam13185
517418004814	histidine kinase; Provisional; Region: PRK13557
517418004815	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418004816	putative active site [active]
517418004817	heme pocket [chemical binding]; other site
517418004818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418004819	ATP binding site [chemical binding]; other site
517418004820	Mg2+ binding site [ion binding]; other site
517418004821	G-X-G motif; other site
517418004822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418004823	active site
517418004824	phosphorylation site [posttranslational modification]
517418004825	intermolecular recognition site; other site
517418004826	dimerization interface [polypeptide binding]; other site
517418004827	adenylosuccinate lyase; Provisional; Region: PRK07492
517418004828	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
517418004829	tetramer interface [polypeptide binding]; other site
517418004830	active site
517418004831	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
517418004832	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
517418004833	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
517418004834	purine monophosphate binding site [chemical binding]; other site
517418004835	dimer interface [polypeptide binding]; other site
517418004836	putative catalytic residues [active]
517418004837	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
517418004838	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
517418004839	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
517418004840	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
517418004841	active site
517418004842	substrate binding site [chemical binding]; other site
517418004843	cosubstrate binding site; other site
517418004844	catalytic site [active]
517418004845	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
517418004846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418004847	FeS/SAM binding site; other site
517418004848	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
517418004849	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
517418004850	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
517418004851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418004852	ATP binding site [chemical binding]; other site
517418004853	Mg2+ binding site [ion binding]; other site
517418004854	G-X-G motif; other site
517418004855	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
517418004856	anchoring element; other site
517418004857	dimer interface [polypeptide binding]; other site
517418004858	ATP binding site [chemical binding]; other site
517418004859	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
517418004860	active site
517418004861	putative metal-binding site [ion binding]; other site
517418004862	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
517418004863	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
517418004864	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
517418004865	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
517418004866	active site
517418004867	Dodecin; Region: Dodecin; cl01328
517418004868	Ion channel; Region: Ion_trans_2; cl11596
517418004869	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
517418004870	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418004871	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
517418004872	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
517418004873	Late embryogenesis abundant protein; Region: LEA_2; cl12118
517418004874	Isochorismatase family; Region: Isochorismatase; pfam00857
517418004875	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
517418004876	catalytic triad [active]
517418004877	dimer interface [polypeptide binding]; other site
517418004878	conserved cis-peptide bond; other site
517418004879	Phosphopantetheine attachment site; Region: PP-binding; cl09936
517418004880	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
517418004881	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
517418004882	dimer interface [polypeptide binding]; other site
517418004883	active site
517418004884	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
517418004885	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
517418004886	dimerization interface [polypeptide binding]; other site
517418004887	active site
517418004888	metal binding site [ion binding]; metal-binding site
517418004889	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
517418004890	dsRNA binding site [nucleotide binding]; other site
517418004891	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
517418004892	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
517418004893	tetramer interface [polypeptide binding]; other site
517418004894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418004895	catalytic residue [active]
517418004896	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
517418004897	Domain of unknown function DUF21; Region: DUF21; pfam01595
517418004898	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
517418004899	Transporter associated domain; Region: CorC_HlyC; cl08393
517418004900	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
517418004901	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
517418004902	Walker A/P-loop; other site
517418004903	ATP binding site [chemical binding]; other site
517418004904	Q-loop/lid; other site
517418004905	ABC transporter signature motif; other site
517418004906	Walker B; other site
517418004907	D-loop; other site
517418004908	H-loop/switch region; other site
517418004909	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
517418004910	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
517418004911	tandem repeat interface [polypeptide binding]; other site
517418004912	oligomer interface [polypeptide binding]; other site
517418004913	active site residues [active]
517418004914	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
517418004915	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
517418004916	tandem repeat interface [polypeptide binding]; other site
517418004917	oligomer interface [polypeptide binding]; other site
517418004918	active site residues [active]
517418004919	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
517418004920	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
517418004921	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
517418004922	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517418004923	active site
517418004924	HIGH motif; other site
517418004925	nucleotide binding site [chemical binding]; other site
517418004926	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
517418004927	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
517418004928	active site
517418004929	KMSKS motif; other site
517418004930	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
517418004931	tRNA binding surface [nucleotide binding]; other site
517418004932	anticodon binding site; other site
517418004933	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
517418004934	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
517418004935	Domain of unknown function (DUF955); Region: DUF955; cl01076
517418004936	Permease; Region: Permease; cl00510
517418004937	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
517418004938	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
517418004939	Walker A/P-loop; other site
517418004940	ATP binding site [chemical binding]; other site
517418004941	Q-loop/lid; other site
517418004942	ABC transporter signature motif; other site
517418004943	Walker B; other site
517418004944	D-loop; other site
517418004945	H-loop/switch region; other site
517418004946	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
517418004947	mce related protein; Region: MCE; pfam02470
517418004948	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
517418004949	putative active site [active]
517418004950	putative metal binding residues [ion binding]; other site
517418004951	signature motif; other site
517418004952	putative triphosphate binding site [ion binding]; other site
517418004953	dimer interface [polypeptide binding]; other site
517418004954	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
517418004955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418004956	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
517418004957	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418004958	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
517418004959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418004960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418004961	MoxR-like ATPases [General function prediction only]; Region: COG0714
517418004962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418004963	Walker A motif; other site
517418004964	ATP binding site [chemical binding]; other site
517418004965	Walker B motif; other site
517418004966	arginine finger; other site
517418004967	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418004968	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418004969	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418004970	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418004971	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
517418004972	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
517418004973	Response regulator receiver domain; Region: Response_reg; pfam00072
517418004974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418004975	active site
517418004976	phosphorylation site [posttranslational modification]
517418004977	intermolecular recognition site; other site
517418004978	dimerization interface [polypeptide binding]; other site
517418004979	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418004980	dimer interface [polypeptide binding]; other site
517418004981	phosphorylation site [posttranslational modification]
517418004982	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
517418004983	Found in ATP-dependent protease La (LON); Region: LON; smart00464
517418004984	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418004985	Walker A motif; other site
517418004986	ATP binding site [chemical binding]; other site
517418004987	Walker B motif; other site
517418004988	arginine finger; other site
517418004989	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
517418004990	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418004991	putative acyl-acceptor binding pocket; other site
517418004992	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
517418004993	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
517418004994	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
517418004995	active site
517418004996	metal binding site [ion binding]; metal-binding site
517418004997	Cation efflux family; Region: Cation_efflux; cl00316
517418004998	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
517418004999	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
517418005000	MatE; Region: MatE; cl10513
517418005001	MatE; Region: MatE; cl10513
517418005002	Predicted methyltransferase [General function prediction only]; Region: COG2520
517418005003	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005004	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
517418005005	classical (c) SDRs; Region: SDR_c; cd05233
517418005006	NAD(P) binding site [chemical binding]; other site
517418005007	active site
517418005008	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
517418005009	FAD binding domain; Region: FAD_binding_4; pfam01565
517418005010	Divergent PAP2 family; Region: DUF212; cl00855
517418005011	UbiA prenyltransferase family; Region: UbiA; cl00337
517418005012	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
517418005013	RNA/DNA binding site [nucleotide binding]; other site
517418005014	RRM dimerization site [polypeptide binding]; other site
517418005015	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
517418005016	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
517418005017	active site
517418005018	substrate binding site [chemical binding]; other site
517418005019	metal binding site [ion binding]; metal-binding site
517418005020	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
517418005021	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
517418005022	Proline dehydrogenase; Region: Pro_dh; cl03282
517418005023	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
517418005024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418005025	Walker A motif; other site
517418005026	ATP binding site [chemical binding]; other site
517418005027	Walker B motif; other site
517418005028	arginine finger; other site
517418005029	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418005030	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
517418005031	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
517418005032	active site
517418005033	lipoprotein signal peptidase; Provisional; Region: PRK14787
517418005034	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
517418005035	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
517418005036	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
517418005037	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
517418005038	shikimate binding site; other site
517418005039	NAD(P) binding site [chemical binding]; other site
517418005040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005041	binding surface
517418005042	TPR motif; other site
517418005043	TPR repeat; Region: TPR_11; pfam13414
517418005044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005045	binding surface
517418005046	TPR repeat; Region: TPR_11; pfam13414
517418005047	TPR motif; other site
517418005048	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005049	binding surface
517418005050	TPR repeat; Region: TPR_11; pfam13414
517418005051	TPR motif; other site
517418005052	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517418005053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418005054	TPR repeat; Region: TPR_11; pfam13414
517418005055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005056	binding surface
517418005057	TPR motif; other site
517418005058	TPR repeat; Region: TPR_11; pfam13414
517418005059	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
517418005060	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
517418005061	active site
517418005062	dimer interface [polypeptide binding]; other site
517418005063	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
517418005064	dimer interface [polypeptide binding]; other site
517418005065	active site
517418005066	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
517418005067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
517418005068	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418005069	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418005070	putative active site [active]
517418005071	heme pocket [chemical binding]; other site
517418005072	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418005073	PAS domain; Region: PAS_9; pfam13426
517418005074	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418005075	dimer interface [polypeptide binding]; other site
517418005076	phosphorylation site [posttranslational modification]
517418005077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418005078	ATP binding site [chemical binding]; other site
517418005079	Mg2+ binding site [ion binding]; other site
517418005080	G-X-G motif; other site
517418005081	Response regulator receiver domain; Region: Response_reg; pfam00072
517418005082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418005083	active site
517418005084	phosphorylation site [posttranslational modification]
517418005085	intermolecular recognition site; other site
517418005086	dimerization interface [polypeptide binding]; other site
517418005087	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
517418005088	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
517418005089	oligomerisation interface [polypeptide binding]; other site
517418005090	mobile loop; other site
517418005091	roof hairpin; other site
517418005092	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
517418005093	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
517418005094	ring oligomerisation interface [polypeptide binding]; other site
517418005095	ATP/Mg binding site [chemical binding]; other site
517418005096	stacking interactions; other site
517418005097	hinge regions; other site
517418005098	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
517418005099	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517418005100	RNA binding surface [nucleotide binding]; other site
517418005101	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
517418005102	active site
517418005103	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
517418005104	homotrimer interaction site [polypeptide binding]; other site
517418005105	putative active site [active]
517418005106	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
517418005107	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418005108	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517418005109	EamA-like transporter family; Region: EamA; cl01037
517418005110	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
517418005111	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
517418005112	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
517418005113	active site
517418005114	catalytic residues [active]
517418005115	metal binding site [ion binding]; metal-binding site
517418005116	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
517418005117	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
517418005118	substrate binding site [chemical binding]; other site
517418005119	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
517418005120	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
517418005121	substrate binding site [chemical binding]; other site
517418005122	ligand binding site [chemical binding]; other site
517418005123	2-isopropylmalate synthase; Validated; Region: PRK00915
517418005124	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
517418005125	active site
517418005126	catalytic residues [active]
517418005127	metal binding site [ion binding]; metal-binding site
517418005128	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
517418005129	tartrate dehydrogenase; Provisional; Region: PRK08194
517418005130	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
517418005131	ketol-acid reductoisomerase; Provisional; Region: PRK05479
517418005132	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005133	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
517418005134	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
517418005135	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
517418005136	putative valine binding site [chemical binding]; other site
517418005137	dimer interface [polypeptide binding]; other site
517418005138	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
517418005139	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
517418005140	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
517418005141	PYR/PP interface [polypeptide binding]; other site
517418005142	dimer interface [polypeptide binding]; other site
517418005143	TPP binding site [chemical binding]; other site
517418005144	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
517418005145	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
517418005146	TPP-binding site [chemical binding]; other site
517418005147	dimer interface [polypeptide binding]; other site
517418005148	Dehydratase family; Region: ILVD_EDD; cl00340
517418005149	Response regulator receiver domain; Region: Response_reg; pfam00072
517418005150	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418005151	active site
517418005152	phosphorylation site [posttranslational modification]
517418005153	intermolecular recognition site; other site
517418005154	dimerization interface [polypeptide binding]; other site
517418005155	DsrC like protein; Region: DsrC; cl01101
517418005156	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
517418005157	octamerization interface [polypeptide binding]; other site
517418005158	diferric-oxygen binding site [ion binding]; other site
517418005159	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
517418005160	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
517418005161	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
517418005162	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
517418005163	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418005164	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
517418005165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418005166	dimer interface [polypeptide binding]; other site
517418005167	conserved gate region; other site
517418005168	putative PBP binding loops; other site
517418005169	ABC-ATPase subunit interface; other site
517418005170	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
517418005171	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
517418005172	peptide binding site [polypeptide binding]; other site
517418005173	Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751
517418005174	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
517418005175	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418005176	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
517418005177	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418005178	motif II; other site
517418005179	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
517418005180	Predicted amidohydrolase [General function prediction only]; Region: COG0388
517418005181	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
517418005182	putative active site [active]
517418005183	catalytic triad [active]
517418005184	putative dimer interface [polypeptide binding]; other site
517418005185	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
517418005186	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418005187	motif II; other site
517418005188	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
517418005189	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418005190	N-terminal plug; other site
517418005191	ligand-binding site [chemical binding]; other site
517418005192	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
517418005193	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418005194	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
517418005195	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418005196	Gram-negative bacterial tonB protein; Region: TonB; cl10048
517418005197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517418005198	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418005199	dimer interface [polypeptide binding]; other site
517418005200	phosphorylation site [posttranslational modification]
517418005201	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418005202	ATP binding site [chemical binding]; other site
517418005203	Mg2+ binding site [ion binding]; other site
517418005204	G-X-G motif; other site
517418005205	Response regulator receiver domain; Region: Response_reg; pfam00072
517418005206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418005207	active site
517418005208	phosphorylation site [posttranslational modification]
517418005209	intermolecular recognition site; other site
517418005210	dimerization interface [polypeptide binding]; other site
517418005211	Response regulator receiver domain; Region: Response_reg; pfam00072
517418005212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418005213	active site
517418005214	phosphorylation site [posttranslational modification]
517418005215	intermolecular recognition site; other site
517418005216	dimerization interface [polypeptide binding]; other site
517418005217	CheB methylesterase; Region: CheB_methylest; pfam01339
517418005218	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
517418005219	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
517418005220	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005221	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
517418005222	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
517418005223	PAS domain; Region: PAS_10; pfam13596
517418005224	PAS fold; Region: PAS_3; pfam08447
517418005225	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418005226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418005227	putative active site [active]
517418005228	heme pocket [chemical binding]; other site
517418005229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418005230	dimer interface [polypeptide binding]; other site
517418005231	phosphorylation site [posttranslational modification]
517418005232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418005233	ATP binding site [chemical binding]; other site
517418005234	Mg2+ binding site [ion binding]; other site
517418005235	G-X-G motif; other site
517418005236	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
517418005237	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
517418005238	active site
517418005239	catalytic residues [active]
517418005240	metal binding site [ion binding]; metal-binding site
517418005241	Nif-specific regulatory protein; Region: nifA; TIGR01817
517418005242	GAF domain; Region: GAF; cl15785
517418005243	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418005244	Walker A motif; other site
517418005245	ATP binding site [chemical binding]; other site
517418005246	Walker B motif; other site
517418005247	arginine finger; other site
517418005248	Helix-turn-helix domains; Region: HTH; cl00088
517418005249	peroxiredoxin; Provisional; Region: PRK13189
517418005250	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
517418005251	dimer interface [polypeptide binding]; other site
517418005252	decamer (pentamer of dimers) interface [polypeptide binding]; other site
517418005253	catalytic triad [active]
517418005254	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
517418005255	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517418005256	catalytic residue [active]
517418005257	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
517418005258	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
517418005259	active site
517418005260	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
517418005261	active site
517418005262	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005263	PspC domain; Region: PspC; cl00864
517418005264	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
517418005265	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
517418005266	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418005267	FeS/SAM binding site; other site
517418005268	TRAM domain; Region: TRAM; cl01282
517418005269	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418005270	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517418005271	Cation efflux family; Region: Cation_efflux; cl00316
517418005272	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
517418005273	anti sigma factor interaction site; other site
517418005274	regulatory phosphorylation site [posttranslational modification]; other site
517418005275	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
517418005276	Bacterial Ig-like domain; Region: Big_5; cl01012
517418005277	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418005278	glycogen synthase; Provisional; Region: glgA; PRK00654
517418005279	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
517418005280	ADP-binding pocket [chemical binding]; other site
517418005281	homodimer interface [polypeptide binding]; other site
517418005282	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
517418005283	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418005284	active site
517418005285	motif I; other site
517418005286	motif II; other site
517418005287	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
517418005288	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
517418005289	generic binding surface II; other site
517418005290	generic binding surface I; other site
517418005291	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517418005292	DNA repair protein RadA; Provisional; Region: PRK11823
517418005293	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
517418005294	Walker A motif/ATP binding site; other site
517418005295	ATP binding site [chemical binding]; other site
517418005296	Walker B motif; other site
517418005297	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
517418005298	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
517418005299	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
517418005300	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418005301	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418005302	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418005303	Helix-turn-helix domains; Region: HTH; cl00088
517418005304	WHG domain; Region: WHG; pfam13305
517418005305	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
517418005306	ligand binding site [chemical binding]; other site
517418005307	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
517418005308	substrate binding site [chemical binding]; other site
517418005309	multimerization interface [polypeptide binding]; other site
517418005310	ATP binding site [chemical binding]; other site
517418005311	GTP-binding protein YchF; Reviewed; Region: PRK09601
517418005312	YchF GTPase; Region: YchF; cd01900
517418005313	G1 box; other site
517418005314	GTP/Mg2+ binding site [chemical binding]; other site
517418005315	Switch I region; other site
517418005316	G2 box; other site
517418005317	Switch II region; other site
517418005318	G3 box; other site
517418005319	G4 box; other site
517418005320	G5 box; other site
517418005321	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
517418005322	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517418005323	putative metal binding site [ion binding]; other site
517418005324	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
517418005325	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
517418005326	metal binding site [ion binding]; metal-binding site
517418005327	dimer interface [polypeptide binding]; other site
517418005328	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
517418005329	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
517418005330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005331	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418005332	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
517418005333	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
517418005334	primosome assembly protein PriA; Validated; Region: PRK05580
517418005335	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517418005336	ATP binding site [chemical binding]; other site
517418005337	putative Mg++ binding site [ion binding]; other site
517418005338	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418005339	ATP-binding site [chemical binding]; other site
517418005340	phytoene desaturase; Region: phytoene_desat; TIGR02731
517418005341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005343	magnesium chelatase, H subunit; Region: BchH; TIGR02025
517418005344	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
517418005345	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418005346	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418005347	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517418005348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005349	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
517418005350	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
517418005351	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
517418005352	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
517418005353	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
517418005354	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517418005355	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
517418005356	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005357	Walker A/P-loop; other site
517418005358	ATP binding site [chemical binding]; other site
517418005359	Q-loop/lid; other site
517418005360	ABC transporter signature motif; other site
517418005361	Walker B; other site
517418005362	D-loop; other site
517418005363	H-loop/switch region; other site
517418005364	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005366	binding surface
517418005367	TPR motif; other site
517418005368	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005369	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
517418005370	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
517418005371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418005372	dimer interface [polypeptide binding]; other site
517418005373	phosphorylation site [posttranslational modification]
517418005374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418005375	ATP binding site [chemical binding]; other site
517418005376	Mg2+ binding site [ion binding]; other site
517418005377	G-X-G motif; other site
517418005378	Response regulator receiver domain; Region: Response_reg; pfam00072
517418005379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418005380	active site
517418005381	phosphorylation site [posttranslational modification]
517418005382	intermolecular recognition site; other site
517418005383	dimerization interface [polypeptide binding]; other site
517418005384	Response regulator receiver domain; Region: Response_reg; pfam00072
517418005385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418005386	active site
517418005387	phosphorylation site [posttranslational modification]
517418005388	intermolecular recognition site; other site
517418005389	dimerization interface [polypeptide binding]; other site
517418005390	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
517418005391	active site
517418005392	catalytic site [active]
517418005393	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
517418005394	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
517418005395	dimer interface [polypeptide binding]; other site
517418005396	catalytic residue [active]
517418005397	metal binding site [ion binding]; metal-binding site
517418005398	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
517418005399	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
517418005400	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005401	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
517418005402	Uncharacterized conserved protein [Function unknown]; Region: COG1912
517418005403	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
517418005404	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005405	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
517418005406	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
517418005407	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
517418005408	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_1; cd03400
517418005409	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418005410	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418005411	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418005412	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418005413	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418005414	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418005415	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
517418005416	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005417	Walker A/P-loop; other site
517418005418	ATP binding site [chemical binding]; other site
517418005419	Q-loop/lid; other site
517418005420	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005421	ABC transporter signature motif; other site
517418005422	Walker B; other site
517418005423	D-loop; other site
517418005424	H-loop/switch region; other site
517418005425	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
517418005426	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
517418005427	radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089
517418005428	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
517418005429	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
517418005430	active site
517418005431	catalytic triad [active]
517418005432	Family description; Region: VCBS; pfam13517
517418005433	Family description; Region: VCBS; pfam13517
517418005434	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
517418005435	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418005436	Domain of unknown function (DUF386); Region: DUF386; cl01047
517418005437	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005438	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517418005440	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005442	binding surface
517418005443	TPR motif; other site
517418005444	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005446	binding surface
517418005447	TPR motif; other site
517418005448	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418005449	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418005450	metal binding site [ion binding]; metal-binding site
517418005451	active site
517418005452	I-site; other site
517418005453	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
517418005454	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
517418005455	active site
517418005456	HIGH motif; other site
517418005457	KMSKS motif; other site
517418005458	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
517418005459	tRNA binding surface [nucleotide binding]; other site
517418005460	anticodon binding site; other site
517418005461	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
517418005462	dimer interface [polypeptide binding]; other site
517418005463	putative tRNA-binding site [nucleotide binding]; other site
517418005464	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
517418005465	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
517418005466	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005467	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
517418005468	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
517418005469	Predicted transcriptional regulator [Transcription]; Region: COG2378
517418005470	WYL domain; Region: WYL; cl14852
517418005471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
517418005472	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
517418005473	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
517418005474	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418005475	Gram-negative bacterial tonB protein; Region: TonB; cl10048
517418005476	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418005477	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
517418005478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418005479	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418005480	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
517418005481	AIR carboxylase; Region: AIRC; cl00310
517418005482	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
517418005483	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418005484	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
517418005485	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
517418005486	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
517418005487	ligand binding site [chemical binding]; other site
517418005488	IncA protein; Region: IncA; pfam04156
517418005489	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
517418005490	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
517418005491	putative NADP binding site [chemical binding]; other site
517418005492	putative substrate binding site [chemical binding]; other site
517418005493	active site
517418005494	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
517418005495	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418005496	ligand binding site [chemical binding]; other site
517418005497	flexible hinge region; other site
517418005498	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
517418005499	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
517418005500	metal binding triad; other site
517418005501	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
517418005502	active site
517418005503	substrate binding site [chemical binding]; other site
517418005504	catalytic site [active]
517418005505	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418005506	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
517418005507	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
517418005508	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
517418005509	SLBB domain; Region: SLBB; pfam10531
517418005510	4Fe-4S binding domain; Region: Fer4; cl02805
517418005511	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
517418005512	FMN-binding domain; Region: FMN_bind; cl01081
517418005513	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
517418005514	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
517418005515	ApbE family; Region: ApbE; cl00643
517418005516	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
517418005517	ferredoxin; Validated; Region: PRK07118
517418005518	Putative Fe-S cluster; Region: FeS; pfam04060
517418005519	4Fe-4S binding domain; Region: Fer4; cl02805
517418005520	4Fe-4S binding domain; Region: Fer4; cl02805
517418005521	recombination factor protein RarA; Reviewed; Region: PRK13342
517418005522	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418005523	Walker A motif; other site
517418005524	ATP binding site [chemical binding]; other site
517418005525	Walker B motif; other site
517418005526	arginine finger; other site
517418005527	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
517418005528	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
517418005529	homodimer interface [polypeptide binding]; other site
517418005530	NAD synthase; Region: NAD_synthase; pfam02540
517418005531	NAD binding pocket [chemical binding]; other site
517418005532	ATP binding pocket [chemical binding]; other site
517418005533	Mg binding site [ion binding]; other site
517418005534	active-site loop [active]
517418005535	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
517418005536	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
517418005537	putative ribose interaction site [chemical binding]; other site
517418005538	putative ADP binding site [chemical binding]; other site
517418005539	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
517418005540	active site
517418005541	catalytic triad [active]
517418005542	oxyanion hole [active]
517418005543	switch loop; other site
517418005544	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418005545	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418005546	Walker A/P-loop; other site
517418005547	ATP binding site [chemical binding]; other site
517418005548	Q-loop/lid; other site
517418005549	ABC transporter signature motif; other site
517418005550	Walker B; other site
517418005551	D-loop; other site
517418005552	H-loop/switch region; other site
517418005553	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
517418005554	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418005555	FtsX-like permease family; Region: FtsX; cl15850
517418005556	competence damage-inducible protein A; Provisional; Region: PRK00549
517418005557	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
517418005558	putative MPT binding site; other site
517418005559	Competence-damaged protein; Region: CinA; cl00666
517418005560	GAF domain; Region: GAF_2; pfam13185
517418005561	GAF domain; Region: GAF; cl15785
517418005562	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
517418005563	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418005564	GAF domain; Region: GAF; cl15785
517418005565	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
517418005566	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418005567	alanine racemase; Reviewed; Region: alr; PRK00053
517418005568	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
517418005569	active site
517418005570	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517418005571	dimer interface [polypeptide binding]; other site
517418005572	substrate binding site [chemical binding]; other site
517418005573	catalytic residues [active]
517418005574	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
517418005575	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418005576	Predicted esterase [General function prediction only]; Region: COG0627
517418005577	Predicted ATPase [General function prediction only]; Region: COG4637
517418005578	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005579	Walker A/P-loop; other site
517418005580	ATP binding site [chemical binding]; other site
517418005581	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005582	ABC transporter signature motif; other site
517418005583	Walker B; other site
517418005584	D-loop; other site
517418005585	H-loop/switch region; other site
517418005586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005587	binding surface
517418005588	TPR repeat; Region: TPR_11; pfam13414
517418005589	TPR motif; other site
517418005590	TPR repeat; Region: TPR_11; pfam13414
517418005591	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005592	binding surface
517418005593	TPR motif; other site
517418005594	TPR repeat; Region: TPR_11; pfam13414
517418005595	TPR repeat; Region: TPR_11; pfam13414
517418005596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005597	TPR motif; other site
517418005598	binding surface
517418005599	TPR repeat; Region: TPR_11; pfam13414
517418005600	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
517418005601	putative dimer interface [polypeptide binding]; other site
517418005602	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
517418005603	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
517418005604	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418005605	metal ion-dependent adhesion site (MIDAS); other site
517418005606	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
517418005607	CHAT domain; Region: CHAT; pfam12770
517418005608	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
517418005609	Prephenate dehydratase; Region: PDT; pfam00800
517418005610	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
517418005611	putative L-Phe binding site [chemical binding]; other site
517418005612	Transcriptional regulator; Region: Transcrip_reg; cl00361
517418005613	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
517418005614	active site
517418005615	putative DNA-binding cleft [nucleotide binding]; other site
517418005616	dimer interface [polypeptide binding]; other site
517418005617	TspO/MBR family; Region: TspO_MBR; cl01379
517418005618	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
517418005619	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
517418005620	NAD binding site [chemical binding]; other site
517418005621	substrate binding site [chemical binding]; other site
517418005622	homodimer interface [polypeptide binding]; other site
517418005623	active site
517418005624	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
517418005625	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005626	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
517418005627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005628	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
517418005629	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
517418005630	Substrate binding site; other site
517418005631	Mg++ binding site; other site
517418005632	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
517418005633	tetramerization interface [polypeptide binding]; other site
517418005634	active site
517418005635	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
517418005636	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
517418005637	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
517418005638	periplasmic chaperone; Provisional; Region: PRK10780
517418005639	Bifunctional nuclease; Region: DNase-RNase; cl00553
517418005640	UvrB/uvrC motif; Region: UVR; pfam02151
517418005641	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
517418005642	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
517418005643	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
517418005644	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
517418005645	Ligand binding site [chemical binding]; other site
517418005646	Ion transport protein; Region: Ion_trans; pfam00520
517418005647	Ion channel; Region: Ion_trans_2; cl11596
517418005648	Double zinc ribbon; Region: DZR; pfam12773
517418005649	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
517418005650	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418005651	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418005652	Walker A/P-loop; other site
517418005653	ATP binding site [chemical binding]; other site
517418005654	Q-loop/lid; other site
517418005655	ABC transporter signature motif; other site
517418005656	Walker B; other site
517418005657	D-loop; other site
517418005658	H-loop/switch region; other site
517418005659	Protein of unknown function (DUF541); Region: SIMPL; cl01077
517418005660	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
517418005661	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
517418005662	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
517418005663	Ligand binding site; other site
517418005664	Putative Catalytic site; other site
517418005665	DXD motif; other site
517418005666	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
517418005667	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
517418005668	active site
517418005669	substrate binding site [chemical binding]; other site
517418005670	Mg2+ binding site [ion binding]; other site
517418005671	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
517418005672	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
517418005673	GatB domain; Region: GatB_Yqey; cl11497
517418005674	Clp amino terminal domain; Region: Clp_N; pfam02861
517418005675	Clp amino terminal domain; Region: Clp_N; pfam02861
517418005676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418005677	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
517418005678	Walker A motif; other site
517418005679	ATP binding site [chemical binding]; other site
517418005680	Walker B motif; other site
517418005681	arginine finger; other site
517418005682	DoxX-like family; Region: DoxX_3; pfam13781
517418005683	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
517418005684	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
517418005685	Substrate binding site; other site
517418005686	Cupin domain; Region: Cupin_2; cl09118
517418005687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005688	TPR motif; other site
517418005689	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517418005690	binding surface
517418005691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005692	TPR motif; other site
517418005693	TPR repeat; Region: TPR_11; pfam13414
517418005694	binding surface
517418005695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005696	binding surface
517418005697	TPR motif; other site
517418005698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
517418005699	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
517418005700	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
517418005701	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
517418005702	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
517418005703	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418005704	ligand binding site [chemical binding]; other site
517418005705	flexible hinge region; other site
517418005706	pteridine reductase; Provisional; Region: PRK09135
517418005707	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005708	NAD(P) binding site [chemical binding]; other site
517418005709	active site
517418005710	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418005711	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
517418005712	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418005713	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
517418005714	HrcA protein C terminal domain; Region: HrcA; pfam01628
517418005715	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
517418005716	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
517418005717	dimer interface [polypeptide binding]; other site
517418005718	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
517418005719	chaperone protein DnaJ; Provisional; Region: PRK14281
517418005720	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
517418005721	HSP70 interaction site [polypeptide binding]; other site
517418005722	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
517418005723	Zn binding sites [ion binding]; other site
517418005724	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
517418005725	dimer interface [polypeptide binding]; other site
517418005726	HupF/HypC family; Region: HupF_HypC; cl00394
517418005727	Hydrogenase formation hypA family; Region: HypD; cl12072
517418005728	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
517418005729	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
517418005730	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
517418005731	nitrogenase reductase; Reviewed; Region: nifH; PRK13233
517418005732	Nucleotide-binding sites [chemical binding]; other site
517418005733	Walker A motif; other site
517418005734	Switch I region of nucleotide binding site; other site
517418005735	Fe4S4 binding sites [ion binding]; other site
517418005736	Switch II region of nucleotide binding site; other site
517418005737	Nitrogen regulatory protein P-II; Region: P-II; cl00412
517418005738	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517418005739	Nitrogen regulatory protein P-II; Region: P-II; cl00412
517418005740	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517418005741	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
517418005742	Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of,  the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977
517418005743	Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910
517418005744	Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of  the VFe protein of the vanadium-dependent (V-) nitrogenase.  Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973
517418005745	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
517418005746	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
517418005747	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582
517418005748	Fe-only nitrogenase accessory protein AnfO; Region: anfO_nitrog; TIGR02940
517418005749	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418005750	Nif-specific regulatory protein; Region: nifA; TIGR01817
517418005751	GAF domain; Region: GAF; cl15785
517418005752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418005753	Walker A motif; other site
517418005754	ATP binding site [chemical binding]; other site
517418005755	Walker B motif; other site
517418005756	arginine finger; other site
517418005757	Helix-turn-helix domains; Region: HTH; cl00088
517418005758	Transcriptional regulator [Transcription]; Region: LysR; COG0583
517418005759	Helix-turn-helix domains; Region: HTH; cl00088
517418005760	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
517418005761	putative dimerization interface [polypeptide binding]; other site
517418005762	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
517418005763	dimerization interface [polypeptide binding]; other site
517418005764	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
517418005765	ATP binding site [chemical binding]; other site
517418005766	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
517418005767	active site
517418005768	dimerization interface [polypeptide binding]; other site
517418005769	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
517418005770	active site
517418005771	hydrophilic channel; other site
517418005772	dimerization interface [polypeptide binding]; other site
517418005773	catalytic residues [active]
517418005774	active site lid [active]
517418005775	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
517418005776	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
517418005777	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
517418005778	Polysulphide reductase, NrfD; Region: NrfD; cl01295
517418005779	tetrathionate reductase subunit B; Provisional; Region: PRK14993
517418005780	4Fe-4S binding domain; Region: Fer4; cl02805
517418005781	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517418005782	molybdopterin cofactor binding site; other site
517418005783	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517418005784	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517418005785	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
517418005786	putative molybdopterin cofactor binding site; other site
517418005787	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
517418005788	putative active site [active]
517418005789	dimerization interface [polypeptide binding]; other site
517418005790	putative tRNAtyr binding site [nucleotide binding]; other site
517418005791	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
517418005792	Ligand binding site; other site
517418005793	oligomer interface; other site
517418005794	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
517418005795	homotrimer interaction site [polypeptide binding]; other site
517418005796	putative active site [active]
517418005797	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
517418005798	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418005799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418005800	S-adenosylmethionine binding site [chemical binding]; other site
517418005801	fumarate hydratase; Reviewed; Region: fumC; PRK00485
517418005802	Class II fumarases; Region: Fumarase_classII; cd01362
517418005803	active site
517418005804	tetramer interface [polypeptide binding]; other site
517418005805	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
517418005806	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005807	Walker A/P-loop; other site
517418005808	ATP binding site [chemical binding]; other site
517418005809	Q-loop/lid; other site
517418005810	ABC transporter signature motif; other site
517418005811	Walker B; other site
517418005812	D-loop; other site
517418005813	H-loop/switch region; other site
517418005814	ABC transporter; Region: ABC_tran_2; pfam12848
517418005815	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
517418005816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
517418005817	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517418005818	catalytic core [active]
517418005819	polyphosphate kinase; Provisional; Region: PRK05443
517418005820	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
517418005821	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
517418005822	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
517418005823	domain interface [polypeptide binding]; other site
517418005824	active site
517418005825	catalytic site [active]
517418005826	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
517418005827	domain interface [polypeptide binding]; other site
517418005828	active site
517418005829	catalytic site [active]
517418005830	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
517418005831	Ferritin-like domain; Region: Ferritin; pfam00210
517418005832	ferroxidase diiron center [ion binding]; other site
517418005833	Preprotein translocase SecG subunit; Region: SecG; cl09123
517418005834	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
517418005835	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
517418005836	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
517418005837	putative active site pocket [active]
517418005838	4-fold oligomerization interface [polypeptide binding]; other site
517418005839	metal binding residues [ion binding]; metal-binding site
517418005840	3-fold/trimer interface [polypeptide binding]; other site
517418005841	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
517418005842	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517418005843	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005844	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418005845	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
517418005846	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
517418005847	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418005848	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418005849	ligand binding site [chemical binding]; other site
517418005850	flexible hinge region; other site
517418005851	NHL repeat; Region: NHL; pfam01436
517418005852	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
517418005853	N-acetyl-D-glucosamine binding site [chemical binding]; other site
517418005854	catalytic residue [active]
517418005855	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
517418005856	putative peptidoglycan binding site; other site
517418005857	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
517418005858	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
517418005859	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
517418005860	glutamine binding [chemical binding]; other site
517418005861	catalytic triad [active]
517418005862	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
517418005863	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
517418005864	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
517418005865	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
517418005866	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
517418005867	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
517418005868	Cytochrome c; Region: Cytochrom_C; cl11414
517418005869	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
517418005870	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
517418005871	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
517418005872	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
517418005873	Hexamer interface [polypeptide binding]; other site
517418005874	Hexagonal pore residue; other site
517418005875	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
517418005876	Hexamer interface [polypeptide binding]; other site
517418005877	Putative hexagonal pore residue; other site
517418005878	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
517418005879	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
517418005880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418005881	S-adenosylmethionine binding site [chemical binding]; other site
517418005882	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
517418005883	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
517418005884	active site
517418005885	metal binding site [ion binding]; metal-binding site
517418005886	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418005887	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418005888	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418005889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005890	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
517418005891	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
517418005892	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
517418005893	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517418005894	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517418005895	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517418005896	Two component regulator propeller; Region: Reg_prop; pfam07494
517418005897	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
517418005898	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
517418005899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517418005900	Peroxisomal biogenesis factor 11 (PEX11); Region: PEX11; pfam05648
517418005901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418005902	dimer interface [polypeptide binding]; other site
517418005903	phosphorylation site [posttranslational modification]
517418005904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418005905	ATP binding site [chemical binding]; other site
517418005906	Mg2+ binding site [ion binding]; other site
517418005907	G-X-G motif; other site
517418005908	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
517418005909	Sodium:solute symporter family; Region: SSF; cl00456
517418005910	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
517418005911	GAF domain; Region: GAF_2; pfam13185
517418005912	GAF domain; Region: GAF; cl15785
517418005913	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
517418005914	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418005915	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
517418005916	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005917	Walker A/P-loop; other site
517418005918	ATP binding site [chemical binding]; other site
517418005919	Q-loop/lid; other site
517418005920	ABC transporter signature motif; other site
517418005921	Walker B; other site
517418005922	D-loop; other site
517418005923	H-loop/switch region; other site
517418005924	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
517418005925	Helix-turn-helix domain; Region: HTH_18; pfam12833
517418005926	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418005927	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
517418005928	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418005929	diaminopimelate decarboxylase; Region: lysA; TIGR01048
517418005930	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841
517418005931	dimer interface [polypeptide binding]; other site
517418005932	active site
517418005933	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517418005934	catalytic residues [active]
517418005935	substrate binding site [chemical binding]; other site
517418005936	Urea transporter; Region: UT; cl01829
517418005937	Peptidase family M23; Region: Peptidase_M23; pfam01551
517418005938	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
517418005939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418005940	binding surface
517418005941	TPR motif; other site
517418005942	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517418005943	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
517418005944	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418005945	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418005946	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418005947	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418005948	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418005949	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
517418005950	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
517418005951	Surface antigen; Region: Bac_surface_Ag; cl03097
517418005952	Uncharacterized conserved protein [Function unknown]; Region: COG5276
517418005953	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
517418005954	Cadherin repeat-like domain; Region: CA_like; cl15786
517418005955	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
517418005956	S-adenosylmethionine synthetase; Validated; Region: PRK05250
517418005957	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
517418005958	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
517418005959	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
517418005960	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
517418005961	S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401
517418005962	oligomerization interface [polypeptide binding]; other site
517418005963	active site
517418005964	NAD+ binding site [chemical binding]; other site
517418005965	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
517418005966	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
517418005967	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
517418005968	generic binding surface II; other site
517418005969	generic binding surface I; other site
517418005970	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517418005971	catalytic residues [active]
517418005972	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
517418005973	catalytic residues [active]
517418005974	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
517418005975	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418005976	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418005977	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
517418005978	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
517418005979	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
517418005980	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
517418005981	Tetratricopeptide repeat; Region: TPR_6; pfam13174
517418005982	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
517418005983	tol-pal system protein YbgF; Provisional; Region: PRK10803
517418005984	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
517418005985	Sodium:solute symporter family; Region: SSF; cl00456
517418005986	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
517418005987	anti sigma factor interaction site; other site
517418005988	regulatory phosphorylation site [posttranslational modification]; other site
517418005989	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
517418005990	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
517418005991	Transposase [DNA replication, recombination, and repair]; Region: COG5433
517418005992	Transposase [DNA replication, recombination, and repair]; Region: COG5433
517418005993	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517418005994	ligand binding site [chemical binding]; other site
517418005995	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
517418005996	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418005997	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517418005998	catalytic core [active]
517418005999	Maf-like protein; Region: Maf; pfam02545
517418006000	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
517418006001	active site
517418006002	dimer interface [polypeptide binding]; other site
517418006003	Sodium:solute symporter family; Region: SSF; cl00456
517418006004	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
517418006005	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
517418006006	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
517418006007	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
517418006008	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
517418006009	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
517418006010	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
517418006011	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
517418006012	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006013	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
517418006014	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
517418006015	putative acyl-acceptor binding pocket; other site
517418006016	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517418006017	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
517418006018	active site
517418006019	HIGH motif; other site
517418006020	nucleotide binding site [chemical binding]; other site
517418006021	Family of unknown function (DUF490); Region: DUF490; pfam04357
517418006022	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
517418006023	Flavoprotein; Region: Flavoprotein; cl08021
517418006024	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
517418006025	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
517418006026	Fe-S cluster binding site [ion binding]; other site
517418006027	active site
517418006028	replicative DNA helicase; Region: DnaB; TIGR00665
517418006029	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
517418006030	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
517418006031	Walker A motif; other site
517418006032	ATP binding site [chemical binding]; other site
517418006033	Walker B motif; other site
517418006034	DNA binding loops [nucleotide binding]
517418006035	SusE outer membrane protein; Region: SusE; pfam14292
517418006036	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
517418006037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418006038	active site
517418006039	phosphorylation site [posttranslational modification]
517418006040	intermolecular recognition site; other site
517418006041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418006042	Walker A motif; other site
517418006043	ATP binding site [chemical binding]; other site
517418006044	Walker B motif; other site
517418006045	arginine finger; other site
517418006046	Helix-turn-helix domains; Region: HTH; cl00088
517418006047	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
517418006048	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
517418006049	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
517418006050	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517418006051	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517418006052	putative active site [active]
517418006053	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418006054	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418006055	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
517418006056	putative catalytic residue [active]
517418006057	fructokinase; Reviewed; Region: PRK09557
517418006058	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
517418006059	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
517418006060	Protein of unknown function; Region: DUF3971; pfam13116
517418006061	AsmA-like C-terminal region; Region: AsmA_2; cl15864
517418006062	AsmA-like C-terminal region; Region: AsmA_2; cl15864
517418006063	proline aminopeptidase P II; Provisional; Region: PRK10879
517418006064	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
517418006065	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
517418006066	active site
517418006067	TRAM domain; Region: TRAM; cl01282
517418006068	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
517418006069	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006070	S-adenosylmethionine binding site [chemical binding]; other site
517418006071	UbiA prenyltransferase family; Region: UbiA; cl00337
517418006072	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
517418006073	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
517418006074	dimer interface [polypeptide binding]; other site
517418006075	glycine-pyridoxal phosphate binding site [chemical binding]; other site
517418006076	active site
517418006077	folate binding site [chemical binding]; other site
517418006078	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
517418006079	pyruvate kinase; Provisional; Region: PRK05826
517418006080	domain interfaces; other site
517418006081	active site
517418006082	YibE/F-like protein; Region: YibE_F; cl02259
517418006083	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
517418006084	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
517418006085	dimer interface [polypeptide binding]; other site
517418006086	active site
517418006087	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
517418006088	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
517418006089	putative NAD(P) binding site [chemical binding]; other site
517418006090	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517418006091	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
517418006092	homotrimer interface [polypeptide binding]; other site
517418006093	Walker A motif; other site
517418006094	GTP binding site [chemical binding]; other site
517418006095	Walker B motif; other site
517418006096	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
517418006097	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
517418006098	putative dimer interface [polypeptide binding]; other site
517418006099	[2Fe-2S] cluster binding site [ion binding]; other site
517418006100	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
517418006101	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
517418006102	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
517418006103	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
517418006104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006105	S-adenosylmethionine binding site [chemical binding]; other site
517418006106	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006107	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
517418006108	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
517418006109	nucleotide binding site/active site [active]
517418006110	HIT family signature motif; other site
517418006111	catalytic residue [active]
517418006112	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
517418006113	GIY-YIG motif/motif A; other site
517418006114	putative active site [active]
517418006115	putative metal binding site [ion binding]; other site
517418006116	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780
517418006117	hypothetical protein; Reviewed; Region: PRK09588
517418006118	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
517418006119	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
517418006120	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418006121	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517418006122	protein binding site [polypeptide binding]; other site
517418006123	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
517418006124	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
517418006125	Walker A/P-loop; other site
517418006126	ATP binding site [chemical binding]; other site
517418006127	Q-loop/lid; other site
517418006128	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
517418006129	Q-loop/lid; other site
517418006130	ABC transporter signature motif; other site
517418006131	Walker B; other site
517418006132	D-loop; other site
517418006133	H-loop/switch region; other site
517418006134	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
517418006135	dihydrodipicolinate synthase; Region: dapA; TIGR00674
517418006136	dimer interface [polypeptide binding]; other site
517418006137	active site
517418006138	catalytic residue [active]
517418006139	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006140	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
517418006141	putative FMN binding site [chemical binding]; other site
517418006142	putative dimer interface [polypeptide binding]; other site
517418006143	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
517418006144	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
517418006145	tetramer interface [polypeptide binding]; other site
517418006146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418006147	catalytic residue [active]
517418006148	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
517418006149	lipoyl attachment site [posttranslational modification]; other site
517418006150	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
517418006151	AMP-binding enzyme; Region: AMP-binding; cl15778
517418006152	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
517418006153	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
517418006154	active site
517418006155	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
517418006156	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
517418006157	substrate binding site [chemical binding]; other site
517418006158	oxyanion hole (OAH) forming residues; other site
517418006159	trimer interface [polypeptide binding]; other site
517418006160	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418006161	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
517418006162	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
517418006163	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
517418006164	dimer interface [polypeptide binding]; other site
517418006165	tetramer interface [polypeptide binding]; other site
517418006166	PYR/PP interface [polypeptide binding]; other site
517418006167	TPP binding site [chemical binding]; other site
517418006168	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
517418006169	TPP-binding site; other site
517418006170	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
517418006171	chorismate binding enzyme; Region: Chorismate_bind; cl10555
517418006172	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
517418006173	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006174	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
517418006175	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
517418006176	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
517418006177	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
517418006178	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
517418006179	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
517418006180	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
517418006181	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
517418006182	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006183	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
517418006184	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
517418006185	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
517418006186	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
517418006187	active site
517418006188	dimer interface [polypeptide binding]; other site
517418006189	motif 1; other site
517418006190	motif 2; other site
517418006191	motif 3; other site
517418006192	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
517418006193	anticodon binding site; other site
517418006194	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
517418006195	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
517418006196	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
517418006197	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
517418006198	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
517418006199	23S rRNA binding site [nucleotide binding]; other site
517418006200	L21 binding site [polypeptide binding]; other site
517418006201	L13 binding site [polypeptide binding]; other site
517418006202	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
517418006203	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
517418006204	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
517418006205	dimer interface [polypeptide binding]; other site
517418006206	motif 1; other site
517418006207	active site
517418006208	motif 2; other site
517418006209	motif 3; other site
517418006210	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
517418006211	active site
517418006212	catalytic triad [active]
517418006213	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006214	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
517418006215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006216	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951
517418006217	Predicted acetyltransferase [General function prediction only]; Region: COG3153
517418006218	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517418006219	Coenzyme A binding pocket [chemical binding]; other site
517418006220	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
517418006221	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
517418006222	SLBB domain; Region: SLBB; pfam10531
517418006223	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
517418006224	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
517418006225	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
517418006226	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
517418006227	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517418006228	NADH dehydrogenase subunit G; Validated; Region: PRK08166
517418006229	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517418006230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006231	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418006232	putative active site [active]
517418006233	heme pocket [chemical binding]; other site
517418006234	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006235	putative active site [active]
517418006236	heme pocket [chemical binding]; other site
517418006237	PAS domain S-box; Region: sensory_box; TIGR00229
517418006238	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006239	putative active site [active]
517418006240	heme pocket [chemical binding]; other site
517418006241	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418006242	dimer interface [polypeptide binding]; other site
517418006243	phosphorylation site [posttranslational modification]
517418006244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418006245	ATP binding site [chemical binding]; other site
517418006246	Mg2+ binding site [ion binding]; other site
517418006247	G-X-G motif; other site
517418006248	Response regulator receiver domain; Region: Response_reg; pfam00072
517418006249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418006250	active site
517418006251	phosphorylation site [posttranslational modification]
517418006252	intermolecular recognition site; other site
517418006253	dimerization interface [polypeptide binding]; other site
517418006254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418006255	dimer interface [polypeptide binding]; other site
517418006256	conserved gate region; other site
517418006257	putative PBP binding loops; other site
517418006258	ABC-ATPase subunit interface; other site
517418006259	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
517418006260	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418006261	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
517418006262	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418006263	Walker A/P-loop; other site
517418006264	ATP binding site [chemical binding]; other site
517418006265	Q-loop/lid; other site
517418006266	ABC transporter signature motif; other site
517418006267	Walker B; other site
517418006268	D-loop; other site
517418006269	H-loop/switch region; other site
517418006270	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418006271	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418006272	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418006273	MatE; Region: MatE; cl10513
517418006274	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
517418006275	Methyltransferase domain; Region: Methyltransf_31; pfam13847
517418006276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006277	S-adenosylmethionine binding site [chemical binding]; other site
517418006278	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
517418006279	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
517418006280	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
517418006281	active site
517418006282	dimer interface [polypeptide binding]; other site
517418006283	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
517418006284	Ligand Binding Site [chemical binding]; other site
517418006285	Molecular Tunnel; other site
517418006286	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
517418006287	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
517418006288	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
517418006289	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
517418006290	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
517418006291	RNA binding site [nucleotide binding]; other site
517418006292	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517418006293	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006294	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
517418006295	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418006296	ferric uptake regulator; Provisional; Region: fur; PRK09462
517418006297	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
517418006298	metal binding site 2 [ion binding]; metal-binding site
517418006299	putative DNA binding helix; other site
517418006300	metal binding site 1 [ion binding]; metal-binding site
517418006301	dimer interface [polypeptide binding]; other site
517418006302	structural Zn2+ binding site [ion binding]; other site
517418006303	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
517418006304	Peptidase family M48; Region: Peptidase_M48; cl12018
517418006305	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
517418006306	UbiA prenyltransferase family; Region: UbiA; cl00337
517418006307	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
517418006308	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
517418006309	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
517418006310	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
517418006311	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
517418006312	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
517418006313	catalytic residue [active]
517418006314	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
517418006315	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
517418006316	MgtE intracellular N domain; Region: MgtE_N; cl15244
517418006317	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
517418006318	Divalent cation transporter; Region: MgtE; cl00786
517418006319	OpgC protein; Region: OpgC_C; cl00792
517418006320	Acyltransferase family; Region: Acyl_transf_3; pfam01757
517418006321	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
517418006322	dimer interface [polypeptide binding]; other site
517418006323	substrate binding site [chemical binding]; other site
517418006324	ATP binding site [chemical binding]; other site
517418006325	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
517418006326	thiamine phosphate binding site [chemical binding]; other site
517418006327	active site
517418006328	pyrophosphate binding site [ion binding]; other site
517418006329	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
517418006330	thiamine phosphate binding site [chemical binding]; other site
517418006331	active site
517418006332	pyrophosphate binding site [ion binding]; other site
517418006333	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
517418006334	putative active site [active]
517418006335	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
517418006336	ThiS interaction site; other site
517418006337	putative active site [active]
517418006338	tetramer interface [polypeptide binding]; other site
517418006339	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
517418006340	thiS-thiF/thiG interaction site; other site
517418006341	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
517418006342	tryptophan 5-monooxygenase, tetrameric; Region: Trp_5_monoox; TIGR01270
517418006343	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006344	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418006345	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
517418006346	GIY-YIG motif/motif A; other site
517418006347	putative active site [active]
517418006348	putative metal binding site [ion binding]; other site
517418006349	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
517418006350	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
517418006351	catalytic triad [active]
517418006352	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
517418006353	putative active site [active]
517418006354	catalytic triad [active]
517418006355	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006356	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
517418006357	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
517418006358	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418006359	Zn2+ binding site [ion binding]; other site
517418006360	Mg2+ binding site [ion binding]; other site
517418006361	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
517418006362	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
517418006363	chorismate binding enzyme; Region: Chorismate_bind; cl10555
517418006364	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
517418006365	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
517418006366	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418006367	protein binding site [polypeptide binding]; other site
517418006368	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418006369	protein binding site [polypeptide binding]; other site
517418006370	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418006371	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418006372	TPR motif; other site
517418006373	binding surface
517418006374	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418006375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418006376	binding surface
517418006377	TPR motif; other site
517418006378	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418006379	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418006380	metal binding site [ion binding]; metal-binding site
517418006381	active site
517418006382	I-site; other site
517418006383	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
517418006384	NeuB family; Region: NeuB; cl00496
517418006385	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
517418006386	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
517418006387	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
517418006388	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
517418006389	SLBB domain; Region: SLBB; pfam10531
517418006390	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
517418006391	SLBB domain; Region: SLBB; pfam10531
517418006392	Chain length determinant protein; Region: Wzz; cl15801
517418006393	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
517418006394	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
517418006395	Mg++ binding site [ion binding]; other site
517418006396	putative catalytic motif [active]
517418006397	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
517418006398	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
517418006399	substrate binding site; other site
517418006400	tetramer interface; other site
517418006401	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
517418006402	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
517418006403	NADP-binding site; other site
517418006404	homotetramer interface [polypeptide binding]; other site
517418006405	substrate binding site [chemical binding]; other site
517418006406	homodimer interface [polypeptide binding]; other site
517418006407	active site
517418006408	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
517418006409	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
517418006410	NADP binding site [chemical binding]; other site
517418006411	active site
517418006412	putative substrate binding site [chemical binding]; other site
517418006413	MatE; Region: MatE; cl10513
517418006414	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418006415	active site
517418006416	Protein of unknown function (DUF616); Region: DUF616; pfam04765
517418006417	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
517418006418	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
517418006419	Ligand binding site; other site
517418006420	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
517418006421	Probable Catalytic site; other site
517418006422	metal-binding site
517418006423	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
517418006424	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418006425	Walker A motif; other site
517418006426	ATP binding site [chemical binding]; other site
517418006427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418006428	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
517418006429	Walker A motif; other site
517418006430	ATP binding site [chemical binding]; other site
517418006431	Walker B motif; other site
517418006432	arginine finger; other site
517418006433	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
517418006434	metal ion-dependent adhesion site (MIDAS); other site
517418006435	The GLUG motif; Region: Glug; pfam07581
517418006436	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006437	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006438	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
517418006439	Lumazine binding domain; Region: Lum_binding; pfam00677
517418006440	Lumazine binding domain; Region: Lum_binding; pfam00677
517418006441	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
517418006442	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
517418006443	catalytic motif [active]
517418006444	Zn binding site [ion binding]; other site
517418006445	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
517418006446	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
517418006447	catalytic motif [active]
517418006448	Zn binding site [ion binding]; other site
517418006449	Protein of unknown function, DUF547; Region: DUF547; pfam04784
517418006450	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
517418006451	Domain of unknown function (DUF814); Region: DUF814; pfam05670
517418006452	Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278
517418006453	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
517418006454	AMP-binding enzyme; Region: AMP-binding; cl15778
517418006455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006456	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
517418006457	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418006458	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
517418006459	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
517418006460	ligand binding site; other site
517418006461	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
517418006462	TPP-binding site [chemical binding]; other site
517418006463	dimer interface [polypeptide binding]; other site
517418006464	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
517418006465	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
517418006466	PYR/PP interface [polypeptide binding]; other site
517418006467	dimer interface [polypeptide binding]; other site
517418006468	TPP binding site [chemical binding]; other site
517418006469	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517418006470	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
517418006471	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
517418006472	inhibitor-cofactor binding pocket; inhibition site
517418006473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418006474	catalytic residue [active]
517418006475	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
517418006476	active site
517418006477	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
517418006478	DHH family; Region: DHH; pfam01368
517418006479	DHHA1 domain; Region: DHHA1; pfam02272
517418006480	multifunctional aminopeptidase A; Provisional; Region: PRK00913
517418006481	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
517418006482	interface (dimer of trimers) [polypeptide binding]; other site
517418006483	Substrate-binding/catalytic site; other site
517418006484	Zn-binding sites [ion binding]; other site
517418006485	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
517418006486	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418006487	7-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK08416
517418006488	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
517418006489	putative NAD(P) binding site [chemical binding]; other site
517418006490	active site
517418006491	phosphodiesterase; Provisional; Region: PRK12704
517418006492	Uncharacterized conserved protein [Function unknown]; Region: COG3586
517418006493	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
517418006494	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
517418006495	active site
517418006496	catalytic residues [active]
517418006497	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
517418006498	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
517418006499	Zn binding site [ion binding]; other site
517418006500	ApbE family; Region: ApbE; cl00643
517418006501	NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910
517418006502	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
517418006503	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
517418006504	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517418006505	catalytic residues [active]
517418006506	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
517418006507	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
517418006508	Putative zinc ribbon domain; Region: DUF164; pfam02591
517418006509	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
517418006510	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418006511	Walker A/P-loop; other site
517418006512	ATP binding site [chemical binding]; other site
517418006513	Q-loop/lid; other site
517418006514	ABC transporter signature motif; other site
517418006515	Walker B; other site
517418006516	D-loop; other site
517418006517	H-loop/switch region; other site
517418006518	FOG: WD40 repeat [General function prediction only]; Region: COG2319
517418006519	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418006520	structural tetrad; other site
517418006521	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
517418006522	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
517418006523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418006524	FeS/SAM binding site; other site
517418006525	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
517418006526	TM-ABC transporter signature motif; other site
517418006527	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418006528	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
517418006529	Uncharacterized conserved protein [Function unknown]; Region: COG3391
517418006530	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418006531	Walker A motif; other site
517418006532	ATP binding site [chemical binding]; other site
517418006533	Walker B motif; other site
517418006534	Surface antigen; Region: Bac_surface_Ag; cl03097
517418006535	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
517418006536	nucleoside/Zn binding site; other site
517418006537	dimer interface [polypeptide binding]; other site
517418006538	catalytic motif [active]
517418006539	Domain of unknown function (DUF955); Region: DUF955; cl01076
517418006540	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
517418006541	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517418006542	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517418006543	DNA binding residues [nucleotide binding]
517418006544	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517418006545	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
517418006546	active site
517418006547	metal binding site [ion binding]; metal-binding site
517418006548	Bacterial sugar transferase; Region: Bac_transf; cl00939
517418006549	chain length determinant protein EpsF; Region: EpsF; TIGR03017
517418006550	Chain length determinant protein; Region: Wzz; cl15801
517418006551	6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625
517418006552	Chain length determinant protein; Region: Wzz; cl15801
517418006553	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
517418006554	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418006555	P loop; other site
517418006556	Nucleotide binding site [chemical binding]; other site
517418006557	DTAP/Switch II; other site
517418006558	Switch I; other site
517418006559	colanic acid exporter; Provisional; Region: PRK10459
517418006560	MatE; Region: MatE; cl10513
517418006561	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
517418006562	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517418006563	inhibitor-cofactor binding pocket; inhibition site
517418006564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418006565	catalytic residue [active]
517418006566	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418006567	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517418006568	extended (e) SDRs; Region: SDR_e; cd08946
517418006569	NAD(P) binding site [chemical binding]; other site
517418006570	substrate binding site [chemical binding]; other site
517418006571	active site
517418006572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006573	S-adenosylmethionine binding site [chemical binding]; other site
517418006574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006575	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
517418006576	active site
517418006577	catalytic residues [active]
517418006578	metal binding site [ion binding]; metal-binding site
517418006579	Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135
517418006580	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
517418006581	Ligand binding site; other site
517418006582	oligomer interface; other site
517418006583	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
517418006584	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
517418006585	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418006586	active site
517418006587	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418006588	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
517418006589	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
517418006590	putative NAD(P) binding site [chemical binding]; other site
517418006591	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517418006592	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006593	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
517418006594	putative glycosyl transferase; Provisional; Region: PRK10307
517418006595	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
517418006596	Bacterial sugar transferase; Region: Bac_transf; cl00939
517418006597	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651
517418006598	putative active site [active]
517418006599	putative substrate binding site [chemical binding]; other site
517418006600	putative cosubstrate binding site; other site
517418006601	catalytic site [active]
517418006602	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
517418006603	active site
517418006604	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
517418006605	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
517418006606	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
517418006607	putative trimer interface [polypeptide binding]; other site
517418006608	putative CoA binding site [chemical binding]; other site
517418006609	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
517418006610	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517418006611	inhibitor-cofactor binding pocket; inhibition site
517418006612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418006613	catalytic residue [active]
517418006614	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
517418006615	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006616	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
517418006617	NAD(P) binding site [chemical binding]; other site
517418006618	homodimer interface [polypeptide binding]; other site
517418006619	substrate binding site [chemical binding]; other site
517418006620	active site
517418006621	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
517418006622	acetyl-CoA synthetase; Provisional; Region: PRK00174
517418006623	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
517418006624	AMP-binding enzyme; Region: AMP-binding; cl15778
517418006625	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
517418006626	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
517418006627	FMN binding site [chemical binding]; other site
517418006628	substrate binding site [chemical binding]; other site
517418006629	putative catalytic residue [active]
517418006630	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517418006631	catalytic core [active]
517418006632	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
517418006633	substrate binding pocket [chemical binding]; other site
517418006634	Ion channel; Region: Ion_trans_2; cl11596
517418006635	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
517418006636	membrane-bound complex binding site; other site
517418006637	hinge residues; other site
517418006638	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
517418006639	isocitrate dehydrogenase; Validated; Region: PRK06451
517418006640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418006641	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
517418006642	active site
517418006643	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006644	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
517418006645	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006646	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
517418006647	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
517418006648	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
517418006649	active site
517418006650	dimer interface [polypeptide binding]; other site
517418006651	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
517418006652	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
517418006653	active site
517418006654	FMN binding site [chemical binding]; other site
517418006655	substrate binding site [chemical binding]; other site
517418006656	3Fe-4S cluster binding site [ion binding]; other site
517418006657	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
517418006658	domain interface; other site
517418006659	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
517418006660	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006661	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418006662	Transglycosylase; Region: Transgly; cl07896
517418006663	Permease; Region: Permease; cl00510
517418006664	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
517418006665	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418006666	Walker A/P-loop; other site
517418006667	ATP binding site [chemical binding]; other site
517418006668	Q-loop/lid; other site
517418006669	ABC transporter signature motif; other site
517418006670	Walker B; other site
517418006671	D-loop; other site
517418006672	H-loop/switch region; other site
517418006673	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
517418006674	mce related protein; Region: MCE; pfam02470
517418006675	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517418006676	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418006677	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
517418006678	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
517418006679	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
517418006680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006681	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
517418006682	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418006684	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
517418006685	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
517418006686	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
517418006687	PAS domain S-box; Region: sensory_box; TIGR00229
517418006688	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006689	putative active site [active]
517418006690	heme pocket [chemical binding]; other site
517418006691	PAS fold; Region: PAS_3; pfam08447
517418006692	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006693	PAS domain; Region: PAS_9; pfam13426
517418006694	putative active site [active]
517418006695	heme pocket [chemical binding]; other site
517418006696	PAS domain S-box; Region: sensory_box; TIGR00229
517418006697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006698	putative active site [active]
517418006699	heme pocket [chemical binding]; other site
517418006700	PAS domain S-box; Region: sensory_box; TIGR00229
517418006701	PAS domain S-box; Region: sensory_box; TIGR00229
517418006702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006703	putative active site [active]
517418006704	heme pocket [chemical binding]; other site
517418006705	putative diguanylate cyclase; Provisional; Region: PRK09776
517418006706	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418006707	PAS domain; Region: PAS_9; pfam13426
517418006708	PAS fold; Region: PAS_3; pfam08447
517418006709	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418006710	PAS domain S-box; Region: sensory_box; TIGR00229
517418006711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006712	putative active site [active]
517418006713	heme pocket [chemical binding]; other site
517418006714	PAS domain S-box; Region: sensory_box; TIGR00229
517418006715	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418006716	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
517418006717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006718	putative active site [active]
517418006719	heme pocket [chemical binding]; other site
517418006720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418006721	dimer interface [polypeptide binding]; other site
517418006722	phosphorylation site [posttranslational modification]
517418006723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418006724	ATP binding site [chemical binding]; other site
517418006725	Mg2+ binding site [ion binding]; other site
517418006726	G-X-G motif; other site
517418006727	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676
517418006729	BCCT family transporter; Region: BCCT; cl00569
517418006730	phosphoethanolamine N-methyltransferase; Region: PLN02336
517418006731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006732	S-adenosylmethionine binding site [chemical binding]; other site
517418006733	Methyltransferase domain; Region: Methyltransf_31; pfam13847
517418006734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006735	S-adenosylmethionine binding site [chemical binding]; other site
517418006736	CHASE3 domain; Region: CHASE3; cl05000
517418006737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
517418006738	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418006739	metal binding site [ion binding]; metal-binding site
517418006740	active site
517418006741	I-site; other site
517418006742	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517418006743	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418006744	FtsX-like permease family; Region: FtsX; cl15850
517418006745	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517418006746	FtsX-like permease family; Region: FtsX; cl15850
517418006747	Cation efflux family; Region: Cation_efflux; cl00316
517418006748	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
517418006749	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418006750	ligand binding site [chemical binding]; other site
517418006751	flexible hinge region; other site
517418006752	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517418006753	catalytic loop [active]
517418006754	iron binding site [ion binding]; other site
517418006755	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
517418006756	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
517418006757	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
517418006758	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517418006759	helix-hairpin-helix signature motif; other site
517418006760	substrate binding pocket [chemical binding]; other site
517418006761	active site
517418006762	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
517418006763	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517418006764	minor groove reading motif; other site
517418006765	helix-hairpin-helix signature motif; other site
517418006766	substrate binding pocket [chemical binding]; other site
517418006767	active site
517418006768	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
517418006769	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
517418006770	active site
517418006771	8-oxo-dGMP binding site [chemical binding]; other site
517418006772	nudix motif; other site
517418006773	metal binding site [ion binding]; metal-binding site
517418006774	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
517418006775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418006776	motif II; other site
517418006777	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517418006778	NADH(P)-binding; Region: NAD_binding_10; pfam13460
517418006779	NAD(P) binding site [chemical binding]; other site
517418006780	putative active site [active]
517418006781	lipoyl synthase; Provisional; Region: PRK05481
517418006782	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
517418006783	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
517418006784	E3 interaction surface; other site
517418006785	lipoyl attachment site [posttranslational modification]; other site
517418006786	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
517418006787	Protein of unknown function (DUF419); Region: DUF419; cl15265
517418006788	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
517418006789	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
517418006790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418006791	S-adenosylmethionine binding site [chemical binding]; other site
517418006792	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517418006793	catalytic residues [active]
517418006794	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
517418006795	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
517418006796	DNA binding site [nucleotide binding]
517418006797	Int/Topo IB signature motif; other site
517418006798	active site
517418006799	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
517418006800	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418006801	N-terminal plug; other site
517418006802	ligand-binding site [chemical binding]; other site
517418006803	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
517418006804	CbiD; Region: CbiD; cl00828
517418006805	FG-GAP repeat; Region: FG-GAP; cl15299
517418006806	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
517418006807	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
517418006808	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
517418006809	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
517418006810	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
517418006811	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418006812	TIR domain; Region: TIR_2; cl15770
517418006813	FOG: WD40 repeat [General function prediction only]; Region: COG2319
517418006814	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
517418006815	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418006816	structural tetrad; other site
517418006817	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
517418006818	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418006819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
517418006820	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
517418006821	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418006822	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
517418006823	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
517418006824	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418006825	Precorrin-8X methylmutase; Region: CbiC; pfam02570
517418006826	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
517418006827	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418006828	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
517418006829	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
517418006830	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
517418006831	putative active site [active]
517418006832	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
517418006833	putative active site [active]
517418006834	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
517418006835	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
517418006836	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
517418006837	putative FMN binding site [chemical binding]; other site
517418006838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006839	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517418006840	NAD(P) binding site [chemical binding]; other site
517418006841	active site
517418006842	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
517418006843	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
517418006844	Walker A/P-loop; other site
517418006845	ATP binding site [chemical binding]; other site
517418006846	Q-loop/lid; other site
517418006847	ABC transporter signature motif; other site
517418006848	Walker B; other site
517418006849	D-loop; other site
517418006850	H-loop/switch region; other site
517418006851	Cobalt transport protein; Region: CbiQ; cl00463
517418006852	Cobalt transport protein component CbiN; Region: CbiN; cl00842
517418006853	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
517418006854	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
517418006855	Predicted amidohydrolase [General function prediction only]; Region: COG0388
517418006856	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
517418006857	active site
517418006858	catalytic triad [active]
517418006859	dimer interface [polypeptide binding]; other site
517418006860	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
517418006861	dimer interface [polypeptide binding]; other site
517418006862	active site
517418006863	Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808
517418006864	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
517418006865	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
517418006866	putative ligand binding site [chemical binding]; other site
517418006867	Sensory domain found in PocR; Region: PocR; pfam10114
517418006868	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
517418006869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006870	PAS domain; Region: PAS_9; pfam13426
517418006871	putative active site [active]
517418006872	heme pocket [chemical binding]; other site
517418006873	PAS fold; Region: PAS_3; pfam08447
517418006874	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
517418006875	PAS fold; Region: PAS_4; pfam08448
517418006876	PAS domain S-box; Region: sensory_box; TIGR00229
517418006877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418006878	putative active site [active]
517418006879	heme pocket [chemical binding]; other site
517418006880	PAS domain S-box; Region: sensory_box; TIGR00229
517418006881	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418006882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418006883	dimer interface [polypeptide binding]; other site
517418006884	phosphorylation site [posttranslational modification]
517418006885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418006886	ATP binding site [chemical binding]; other site
517418006887	Mg2+ binding site [ion binding]; other site
517418006888	G-X-G motif; other site
517418006889	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
517418006890	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418006891	active site
517418006892	phosphorylation site [posttranslational modification]
517418006893	intermolecular recognition site; other site
517418006894	dimerization interface [polypeptide binding]; other site
517418006895	DNA primase; Validated; Region: dnaG; PRK05667
517418006896	CHC2 zinc finger; Region: zf-CHC2; cl15369
517418006897	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
517418006898	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
517418006899	active site
517418006900	metal binding site [ion binding]; metal-binding site
517418006901	interdomain interaction site; other site
517418006902	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
517418006903	putative peptidase; Provisional; Region: PRK11649
517418006904	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
517418006905	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418006906	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418006907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418006908	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
517418006909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418006910	active site
517418006911	phosphorylation site [posttranslational modification]
517418006912	intermolecular recognition site; other site
517418006913	dimerization interface [polypeptide binding]; other site
517418006914	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
517418006915	DNA binding site [nucleotide binding]
517418006916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
517418006917	dimerization interface [polypeptide binding]; other site
517418006918	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418006919	dimer interface [polypeptide binding]; other site
517418006920	phosphorylation site [posttranslational modification]
517418006921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418006922	ATP binding site [chemical binding]; other site
517418006923	Mg2+ binding site [ion binding]; other site
517418006924	G-X-G motif; other site
517418006925	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
517418006926	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
517418006927	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
517418006928	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
517418006929	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
517418006930	Sulphur transport; Region: Sulf_transp; cl01018
517418006931	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
517418006932	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
517418006933	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418006934	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
517418006935	putative active site [active]
517418006936	putative metal binding site [ion binding]; other site
517418006937	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
517418006938	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
517418006939	Cl- selectivity filter; other site
517418006940	Cl- binding residues [ion binding]; other site
517418006941	pore gating glutamate residue; other site
517418006942	dimer interface [polypeptide binding]; other site
517418006943	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
517418006944	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
517418006945	CoenzymeA binding site [chemical binding]; other site
517418006946	subunit interaction site [polypeptide binding]; other site
517418006947	PHB binding site; other site
517418006948	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
517418006949	AMP-binding enzyme; Region: AMP-binding; cl15778
517418006950	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
517418006951	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418006952	N-terminal plug; other site
517418006953	ligand-binding site [chemical binding]; other site
517418006954	Cytochrome c; Region: Cytochrom_C; cl11414
517418006955	Surface antigen; Region: Bac_surface_Ag; cl03097
517418006956	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418006957	Lamin Tail Domain; Region: LTD; pfam00932
517418006958	Lamin Tail Domain; Region: LTD; pfam00932
517418006959	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418006960	GAF domain; Region: GAF; cl15785
517418006961	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
517418006962	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
517418006963	dimer interface [polypeptide binding]; other site
517418006964	decamer (pentamer of dimers) interface [polypeptide binding]; other site
517418006965	catalytic triad [active]
517418006966	peroxidatic and resolving cysteines [active]
517418006967	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
517418006968	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
517418006969	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
517418006970	DHH family; Region: DHH; pfam01368
517418006971	DHHA1 domain; Region: DHHA1; pfam02272
517418006972	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
517418006973	AMP binding site [chemical binding]; other site
517418006974	metal binding site [ion binding]; metal-binding site
517418006975	active site
517418006976	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
517418006977	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
517418006978	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418006979	CoA-ligase; Region: Ligase_CoA; cl02894
517418006980	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418006981	carboxy-terminal protease; Provisional; Region: PRK11186
517418006982	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517418006983	protein binding site [polypeptide binding]; other site
517418006984	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
517418006985	Catalytic dyad [active]
517418006986	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
517418006987	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418006988	ligand binding site [chemical binding]; other site
517418006989	flexible hinge region; other site
517418006990	LPP20 lipoprotein; Region: LPP20; cl15824
517418006991	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418006992	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006993	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006994	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006995	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418006996	NifZ domain; Region: NifZ; pfam04319
517418006997	NifZ domain; Region: NifZ; pfam04319
517418006998	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
517418006999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007000	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
517418007001	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
517418007002	heterotetramer interface [polypeptide binding]; other site
517418007003	active site pocket [active]
517418007004	cleavage site
517418007005	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
517418007006	feedback inhibition sensing region; other site
517418007007	homohexameric interface [polypeptide binding]; other site
517418007008	nucleotide binding site [chemical binding]; other site
517418007009	N-acetyl-L-glutamate binding site [chemical binding]; other site
517418007010	ornithine carbamoyltransferase; Provisional; Region: PRK00779
517418007011	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
517418007012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007013	Arginine repressor [Transcription]; Region: ArgR; COG1438
517418007014	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
517418007015	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
517418007016	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
517418007017	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
517418007018	ANP binding site [chemical binding]; other site
517418007019	Substrate Binding Site II [chemical binding]; other site
517418007020	Substrate Binding Site I [chemical binding]; other site
517418007021	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
517418007022	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
517418007023	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
517418007024	trimer interface [polypeptide binding]; other site
517418007025	active site
517418007026	UDP-GlcNAc binding site [chemical binding]; other site
517418007027	lipid binding site [chemical binding]; lipid-binding site
517418007028	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
517418007029	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
517418007030	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418007031	active site
517418007032	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
517418007033	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
517418007034	5S rRNA interface [nucleotide binding]; other site
517418007035	CTC domain interface [polypeptide binding]; other site
517418007036	L16 interface [polypeptide binding]; other site
517418007037	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007039	active site
517418007040	phosphorylation site [posttranslational modification]
517418007041	intermolecular recognition site; other site
517418007042	dimerization interface [polypeptide binding]; other site
517418007043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418007044	dimer interface [polypeptide binding]; other site
517418007045	conserved gate region; other site
517418007046	putative PBP binding loops; other site
517418007047	ABC-ATPase subunit interface; other site
517418007048	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
517418007049	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
517418007050	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
517418007051	tRNA; other site
517418007052	putative tRNA binding site [nucleotide binding]; other site
517418007053	putative NADP binding site [chemical binding]; other site
517418007054	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
517418007055	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
517418007056	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
517418007057	domain interfaces; other site
517418007058	active site
517418007059	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
517418007060	active site
517418007061	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
517418007062	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
517418007063	active site
517418007064	nucleophile elbow; other site
517418007065	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
517418007066	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
517418007067	Transposase [DNA replication, recombination, and repair]; Region: COG5433
517418007068	Transposase [DNA replication, recombination, and repair]; Region: COG5433
517418007069	Methyltransferase domain; Region: Methyltransf_31; pfam13847
517418007070	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418007071	S-adenosylmethionine binding site [chemical binding]; other site
517418007072	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
517418007073	active site
517418007074	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
517418007075	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
517418007076	tetramer interface [polypeptide binding]; other site
517418007077	TPP-binding site [chemical binding]; other site
517418007078	heterodimer interface [polypeptide binding]; other site
517418007079	phosphorylation loop region [posttranslational modification]
517418007080	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
517418007081	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
517418007082	PYR/PP interface [polypeptide binding]; other site
517418007083	dimer interface [polypeptide binding]; other site
517418007084	TPP binding site [chemical binding]; other site
517418007085	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517418007086	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
517418007087	dimer interface [polypeptide binding]; other site
517418007088	allosteric magnesium binding site [ion binding]; other site
517418007089	active site
517418007090	aspartate-rich active site metal binding site; other site
517418007091	Schiff base residues; other site
517418007092	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
517418007093	Tetramer interface [polypeptide binding]; other site
517418007094	active site
517418007095	FMN-binding site [chemical binding]; other site
517418007096	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
517418007097	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
517418007098	SmpB-tmRNA interface; other site
517418007099	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
517418007100	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
517418007101	active site
517418007102	HIGH motif; other site
517418007103	dimer interface [polypeptide binding]; other site
517418007104	KMSKS motif; other site
517418007105	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
517418007106	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
517418007107	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
517418007108	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517418007109	B12 binding site [chemical binding]; other site
517418007110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418007111	FeS/SAM binding site; other site
517418007112	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418007113	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
517418007114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
517418007115	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
517418007116	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
517418007117	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
517418007118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517418007119	Walker A motif; other site
517418007120	ATP binding site [chemical binding]; other site
517418007121	Walker B motif; other site
517418007122	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
517418007123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418007124	hypothetical protein; Provisional; Region: PRK13560
517418007125	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007126	putative active site [active]
517418007127	heme pocket [chemical binding]; other site
517418007128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418007129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007130	PAS domain; Region: PAS_9; pfam13426
517418007131	putative active site [active]
517418007132	heme pocket [chemical binding]; other site
517418007133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007134	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418007135	putative active site [active]
517418007136	heme pocket [chemical binding]; other site
517418007137	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007138	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418007139	putative active site [active]
517418007140	heme pocket [chemical binding]; other site
517418007141	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007142	putative active site [active]
517418007143	heme pocket [chemical binding]; other site
517418007144	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418007145	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
517418007146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418007147	dimer interface [polypeptide binding]; other site
517418007148	phosphorylation site [posttranslational modification]
517418007149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418007150	ATP binding site [chemical binding]; other site
517418007151	Mg2+ binding site [ion binding]; other site
517418007152	G-X-G motif; other site
517418007153	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007155	active site
517418007156	phosphorylation site [posttranslational modification]
517418007157	intermolecular recognition site; other site
517418007158	dimerization interface [polypeptide binding]; other site
517418007159	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007160	binding surface
517418007161	TPR motif; other site
517418007162	TPR repeat; Region: TPR_11; pfam13414
517418007163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007164	binding surface
517418007165	TPR motif; other site
517418007166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007167	binding surface
517418007168	TPR repeat; Region: TPR_11; pfam13414
517418007169	TPR motif; other site
517418007170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007171	binding surface
517418007172	TPR motif; other site
517418007173	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
517418007174	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
517418007175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007176	thymidine kinase; Provisional; Region: PRK04296
517418007177	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
517418007178	active site
517418007179	catalytic motif [active]
517418007180	Zn binding site [ion binding]; other site
517418007181	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
517418007182	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
517418007183	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
517418007184	active site
517418007185	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
517418007186	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
517418007187	NAD(P) binding site [chemical binding]; other site
517418007188	catalytic residues [active]
517418007189	Low molecular weight phosphatase family; Region: LMWPc; cd00115
517418007190	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
517418007191	active site
517418007192	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
517418007193	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
517418007194	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
517418007195	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
517418007196	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
517418007197	Cu(I) binding site [ion binding]; other site
517418007198	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
517418007199	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
517418007200	Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702
517418007201	Gram-negative bacterial tonB protein; Region: TonB; cl10048
517418007202	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
517418007203	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
517418007204	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
517418007205	Ferrochelatase; Region: Ferrochelatase; pfam00762
517418007206	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
517418007207	active site
517418007208	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
517418007209	active site
517418007210	N-terminal domain interface [polypeptide binding]; other site
517418007211	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418007212	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418007213	Uncharacterized conserved protein [Function unknown]; Region: COG1262
517418007214	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
517418007215	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
517418007216	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
517418007217	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
517418007218	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007219	GTP/Mg2+ binding site [chemical binding]; other site
517418007220	G5 box; other site
517418007221	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007222	G1 box; other site
517418007223	G1 box; other site
517418007224	GTP/Mg2+ binding site [chemical binding]; other site
517418007225	G2 box; other site
517418007226	Switch I region; other site
517418007227	G3 box; other site
517418007228	Switch II region; other site
517418007229	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
517418007230	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
517418007231	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007232	Dynamin family; Region: Dynamin_N; pfam00350
517418007233	G1 box; other site
517418007234	GTP/Mg2+ binding site [chemical binding]; other site
517418007235	G2 box; other site
517418007236	Switch I region; other site
517418007237	G3 box; other site
517418007238	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
517418007239	G3 box; other site
517418007240	Switch II region; other site
517418007241	GTP/Mg2+ binding site [chemical binding]; other site
517418007242	G4 box; other site
517418007243	G5 box; other site
517418007244	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
517418007245	putative active site [active]
517418007246	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
517418007247	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
517418007248	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
517418007249	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
517418007250	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
517418007251	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517418007252	protein binding site [polypeptide binding]; other site
517418007253	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
517418007254	Catalytic dyad [active]
517418007255	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418007256	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418007257	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
517418007258	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
517418007259	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
517418007260	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
517418007261	dimer interface [polypeptide binding]; other site
517418007262	putative CheW interface [polypeptide binding]; other site
517418007263	AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271
517418007264	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
517418007265	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
517418007266	putative binding surface; other site
517418007267	active site
517418007268	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
517418007269	putative binding surface; other site
517418007270	active site
517418007271	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
517418007272	putative binding surface; other site
517418007273	active site
517418007274	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
517418007275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418007276	ATP binding site [chemical binding]; other site
517418007277	Mg2+ binding site [ion binding]; other site
517418007278	G-X-G motif; other site
517418007279	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
517418007280	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007282	active site
517418007283	phosphorylation site [posttranslational modification]
517418007284	intermolecular recognition site; other site
517418007285	dimerization interface [polypeptide binding]; other site
517418007286	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
517418007287	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
517418007288	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007290	active site
517418007291	phosphorylation site [posttranslational modification]
517418007292	intermolecular recognition site; other site
517418007293	dimerization interface [polypeptide binding]; other site
517418007294	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
517418007295	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
517418007296	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
517418007297	G1 box; other site
517418007298	GTP/Mg2+ binding site [chemical binding]; other site
517418007299	G2 box; other site
517418007300	Switch I region; other site
517418007301	G3 box; other site
517418007302	Switch II region; other site
517418007303	G4 box; other site
517418007304	G5 box; other site
517418007305	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
517418007306	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
517418007307	putative active site; other site
517418007308	catalytic residue [active]
517418007309	Sensors of blue-light using FAD; Region: BLUF; cl04855
517418007310	circadian clock protein KaiC; Reviewed; Region: PRK09302
517418007311	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
517418007312	Walker A motif; other site
517418007313	ATP binding site [chemical binding]; other site
517418007314	Walker B motif; other site
517418007315	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007316	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007317	Walker A motif; other site
517418007318	ATP binding site [chemical binding]; other site
517418007319	Walker B motif; other site
517418007320	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
517418007321	tetramer interface [polypeptide binding]; other site
517418007322	dimer interface [polypeptide binding]; other site
517418007323	GAF domain; Region: GAF; cl15785
517418007324	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
517418007325	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418007326	Haemolysin-III related; Region: HlyIII; cl03831
517418007327	Lamin Tail Domain; Region: LTD; pfam00932
517418007328	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
517418007329	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418007330	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
517418007331	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
517418007332	CoA-binding site [chemical binding]; other site
517418007333	ATP-binding [chemical binding]; other site
517418007334	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
517418007335	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
517418007336	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
517418007337	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
517418007338	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
517418007339	PUA domain; Region: PUA; cl00607
517418007340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418007341	S-adenosylmethionine binding site [chemical binding]; other site
517418007342	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
517418007343	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
517418007344	dimer interface [polypeptide binding]; other site
517418007345	NAD binding site [chemical binding]; other site
517418007346	substrate binding site [chemical binding]; other site
517418007347	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517418007348	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
517418007349	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
517418007350	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517418007351	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517418007352	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517418007353	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
517418007354	LytTr DNA-binding domain; Region: LytTR; cl04498
517418007355	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
517418007356	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
517418007357	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
517418007358	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
517418007359	active site
517418007360	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
517418007361	Uncharacterized conserved protein [Function unknown]; Region: COG2308
517418007362	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
517418007363	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
517418007364	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
517418007365	substrate binding pocket [chemical binding]; other site
517418007366	chain length determination region; other site
517418007367	substrate-Mg2+ binding site; other site
517418007368	catalytic residues [active]
517418007369	aspartate-rich region 1; other site
517418007370	active site lid residues [active]
517418007371	aspartate-rich region 2; other site
517418007372	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
517418007373	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
517418007374	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418007375	FeS/SAM binding site; other site
517418007376	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007378	active site
517418007379	phosphorylation site [posttranslational modification]
517418007380	intermolecular recognition site; other site
517418007381	dimerization interface [polypeptide binding]; other site
517418007382	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
517418007383	LPP20 lipoprotein; Region: LPP20; cl15824
517418007384	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
517418007385	ThiC-associated domain; Region: ThiC-associated; pfam13667
517418007386	ThiC family; Region: ThiC; cl08031
517418007387	PUCC protein; Region: PUCC; pfam03209
517418007388	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
517418007389	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
517418007390	iron-sulfur cluster [ion binding]; other site
517418007391	[2Fe-2S] cluster binding site [ion binding]; other site
517418007392	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
517418007393	Predicted esterase [General function prediction only]; Region: COG0400
517418007394	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418007395	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
517418007396	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
517418007397	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
517418007398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007399	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418007400	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
517418007401	FeS/SAM binding site; other site
517418007402	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
517418007403	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
517418007404	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517418007405	FtsX-like permease family; Region: FtsX; cl15850
517418007406	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418007407	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418007408	Walker A/P-loop; other site
517418007409	ATP binding site [chemical binding]; other site
517418007410	Q-loop/lid; other site
517418007411	ABC transporter signature motif; other site
517418007412	Walker B; other site
517418007413	D-loop; other site
517418007414	H-loop/switch region; other site
517418007415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418007416	S-adenosylmethionine binding site [chemical binding]; other site
517418007417	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
517418007418	DNA photolyase; Region: DNA_photolyase; pfam00875
517418007419	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
517418007420	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007422	active site
517418007423	phosphorylation site [posttranslational modification]
517418007424	intermolecular recognition site; other site
517418007425	dimerization interface [polypeptide binding]; other site
517418007426	PAS domain S-box; Region: sensory_box; TIGR00229
517418007427	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007428	putative active site [active]
517418007429	heme pocket [chemical binding]; other site
517418007430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
517418007431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418007432	ATP binding site [chemical binding]; other site
517418007433	Mg2+ binding site [ion binding]; other site
517418007434	G-X-G motif; other site
517418007435	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007437	active site
517418007438	phosphorylation site [posttranslational modification]
517418007439	intermolecular recognition site; other site
517418007440	dimerization interface [polypeptide binding]; other site
517418007441	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
517418007442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
517418007443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517418007444	dimer interface [polypeptide binding]; other site
517418007445	conserved gate region; other site
517418007446	putative PBP binding loops; other site
517418007447	ABC-ATPase subunit interface; other site
517418007448	rod shape-determining protein MreC; Provisional; Region: PRK13922
517418007449	rod shape-determining protein MreC; Region: MreC; pfam04085
517418007450	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
517418007451	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
517418007452	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
517418007453	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
517418007454	FAD binding domain; Region: FAD_binding_4; pfam01565
517418007455	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
517418007456	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
517418007457	active site
517418007458	Ca binding site [ion binding]; other site
517418007459	catalytic site [active]
517418007460	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
517418007461	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517418007462	ligand binding site [chemical binding]; other site
517418007463	flexible hinge region; other site
517418007464	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
517418007465	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517418007466	NAD(P) binding site [chemical binding]; other site
517418007467	putative active site [active]
517418007468	TIR domain; Region: TIR_2; cl15770
517418007469	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
517418007470	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
517418007471	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517418007472	protein binding site [polypeptide binding]; other site
517418007473	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418007474	active site
517418007475	VanZ like family; Region: VanZ; cl01971
517418007476	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
517418007477	Peptidase family M23; Region: Peptidase_M23; pfam01551
517418007478	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418007479	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
517418007480	Gram-negative bacterial tonB protein; Region: TonB; cl10048
517418007481	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
517418007482	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
517418007483	hinge; other site
517418007484	active site
517418007485	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418007486	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418007487	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418007488	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
517418007489	metal binding site 2 [ion binding]; metal-binding site
517418007490	putative DNA binding helix; other site
517418007491	metal binding site 1 [ion binding]; metal-binding site
517418007492	dimer interface [polypeptide binding]; other site
517418007493	structural Zn2+ binding site [ion binding]; other site
517418007494	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418007495	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
517418007496	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418007497	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
517418007498	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007499	Walker A motif; other site
517418007500	ATP binding site [chemical binding]; other site
517418007501	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007502	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
517418007503	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007504	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
517418007505	metal ion-dependent adhesion site (MIDAS); other site
517418007506	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
517418007507	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418007508	N-terminal plug; other site
517418007509	ligand-binding site [chemical binding]; other site
517418007510	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418007511	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
517418007512	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517418007513	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
517418007514	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517418007515	FeS/SAM binding site; other site
517418007516	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
517418007517	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
517418007518	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
517418007519	intersubunit interface [polypeptide binding]; other site
517418007520	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418007521	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
517418007522	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418007523	N-terminal plug; other site
517418007524	ligand-binding site [chemical binding]; other site
517418007525	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418007526	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
517418007527	Walker A/P-loop; other site
517418007528	ATP binding site [chemical binding]; other site
517418007529	Q-loop/lid; other site
517418007530	ABC transporter signature motif; other site
517418007531	Walker B; other site
517418007532	D-loop; other site
517418007533	H-loop/switch region; other site
517418007534	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
517418007535	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
517418007536	ABC-ATPase subunit  interface; other site
517418007537	dimer interface [polypeptide binding]; other site
517418007538	putative PBP binding regions; other site
517418007539	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
517418007540	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
517418007541	putative ligand binding site [chemical binding]; other site
517418007542	argininosuccinate lyase; Provisional; Region: PRK00855
517418007543	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
517418007544	active sites [active]
517418007545	tetramer interface [polypeptide binding]; other site
517418007546	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
517418007547	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
517418007548	substrate binding site [chemical binding]; other site
517418007549	ligand binding site [chemical binding]; other site
517418007550	Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578
517418007551	substrate binding site [chemical binding]; other site
517418007552	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
517418007553	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
517418007554	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
517418007555	dimerization interface [polypeptide binding]; other site
517418007556	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
517418007557	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
517418007558	dimer interface [polypeptide binding]; other site
517418007559	putative CheW interface [polypeptide binding]; other site
517418007560	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
517418007561	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007562	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007563	active site
517418007564	phosphorylation site [posttranslational modification]
517418007565	intermolecular recognition site; other site
517418007566	dimerization interface [polypeptide binding]; other site
517418007567	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
517418007568	Response regulator receiver domain; Region: Response_reg; pfam00072
517418007569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007570	active site
517418007571	phosphorylation site [posttranslational modification]
517418007572	intermolecular recognition site; other site
517418007573	dimerization interface [polypeptide binding]; other site
517418007574	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
517418007575	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
517418007576	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
517418007577	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
517418007578	RimM N-terminal domain; Region: RimM; pfam01782
517418007579	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
517418007580	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
517418007581	signal recognition particle protein; Provisional; Region: PRK10867
517418007582	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
517418007583	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
517418007584	P loop; other site
517418007585	GTP binding site [chemical binding]; other site
517418007586	Signal peptide binding domain; Region: SRP_SPB; pfam02978
517418007587	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418007588	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418007589	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418007590	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418007591	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418007592	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418007593	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
517418007594	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
517418007595	Walker A/P-loop; other site
517418007596	ATP binding site [chemical binding]; other site
517418007597	Q-loop/lid; other site
517418007598	ABC transporter signature motif; other site
517418007599	Walker B; other site
517418007600	D-loop; other site
517418007601	H-loop/switch region; other site
517418007602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418007603	metal binding site [ion binding]; metal-binding site
517418007604	active site
517418007605	I-site; other site
517418007606	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418007607	YoaP-like; Region: YoaP; pfam14268
517418007608	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
517418007609	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
517418007610	dimer interface [polypeptide binding]; other site
517418007611	active site
517418007612	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
517418007613	dimer interface [polypeptide binding]; other site
517418007614	active site
517418007615	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
517418007616	substrate binding site; other site
517418007617	dimer interface; other site
517418007618	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
517418007619	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
517418007620	TPR repeat; Region: TPR_11; pfam13414
517418007621	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007622	binding surface
517418007623	TPR motif; other site
517418007624	TPR repeat; Region: TPR_11; pfam13414
517418007625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007626	binding surface
517418007627	TPR motif; other site
517418007628	thymidylate kinase; Validated; Region: tmk; PRK00698
517418007629	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
517418007630	TMP-binding site; other site
517418007631	ATP-binding site [chemical binding]; other site
517418007632	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418007633	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
517418007634	putative ADP-binding pocket [chemical binding]; other site
517418007635	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418007636	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
517418007637	putative ADP-binding pocket [chemical binding]; other site
517418007638	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517418007639	putative active site [active]
517418007640	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
517418007641	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
517418007642	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
517418007643	Walker A/P-loop; other site
517418007644	ATP binding site [chemical binding]; other site
517418007645	Q-loop/lid; other site
517418007646	ABC transporter signature motif; other site
517418007647	Walker B; other site
517418007648	D-loop; other site
517418007649	H-loop/switch region; other site
517418007650	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517418007651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007652	NAD(P) binding site [chemical binding]; other site
517418007653	active site
517418007654	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
517418007655	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
517418007656	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
517418007657	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
517418007658	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
517418007659	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
517418007660	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
517418007661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418007662	putative active site [active]
517418007663	heme pocket [chemical binding]; other site
517418007664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418007665	dimer interface [polypeptide binding]; other site
517418007666	phosphorylation site [posttranslational modification]
517418007667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418007668	ATP binding site [chemical binding]; other site
517418007669	Mg2+ binding site [ion binding]; other site
517418007670	G-X-G motif; other site
517418007671	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418007672	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
517418007673	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
517418007674	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
517418007675	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
517418007676	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
517418007677	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
517418007678	zinc binding site [ion binding]; other site
517418007679	putative ligand binding site [chemical binding]; other site
517418007680	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418007681	structural tetrad; other site
517418007682	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
517418007683	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
517418007684	dimerization interface [polypeptide binding]; other site
517418007685	putative ATP binding site [chemical binding]; other site
517418007686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007687	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
517418007688	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
517418007689	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
517418007690	dimerization interface [polypeptide binding]; other site
517418007691	active site
517418007692	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
517418007693	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
517418007694	Catalytic site [active]
517418007695	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
517418007696	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
517418007697	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
517418007698	GTP-binding protein LepA; Provisional; Region: PRK05433
517418007699	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
517418007700	G1 box; other site
517418007701	putative GEF interaction site [polypeptide binding]; other site
517418007702	GTP/Mg2+ binding site [chemical binding]; other site
517418007703	Switch I region; other site
517418007704	G2 box; other site
517418007705	G3 box; other site
517418007706	Switch II region; other site
517418007707	G4 box; other site
517418007708	G5 box; other site
517418007709	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
517418007710	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
517418007711	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
517418007712	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
517418007713	Helix-turn-helix domains; Region: HTH; cl00088
517418007714	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418007715	metal ion-dependent adhesion site (MIDAS); other site
517418007716	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
517418007717	Protein of unknown function (DUF489); Region: DUF489; cl01097
517418007718	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517418007719	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007720	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
517418007721	putative binding surface; other site
517418007722	active site
517418007723	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517418007724	Ligand Binding Site [chemical binding]; other site
517418007725	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517418007726	catalytic residues [active]
517418007727	OsmC-like protein; Region: OsmC; cl00767
517418007728	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
517418007729	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
517418007730	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
517418007731	metal-binding site
517418007732	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
517418007733	metal-binding site
517418007734	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418007735	active site
517418007736	putative glycosyl transferase; Provisional; Region: PRK10125
517418007737	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
517418007738	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007740	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
517418007741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007742	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
517418007743	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
517418007744	Walker A/P-loop; other site
517418007745	ATP binding site [chemical binding]; other site
517418007746	Q-loop/lid; other site
517418007747	ABC transporter signature motif; other site
517418007748	Walker B; other site
517418007749	D-loop; other site
517418007750	H-loop/switch region; other site
517418007751	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
517418007752	putative carbohydrate binding site [chemical binding]; other site
517418007753	ABC-2 type transporter; Region: ABC2_membrane; cl11417
517418007754	Right handed beta helix region; Region: Beta_helix; pfam13229
517418007755	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
517418007756	Chain length determinant protein; Region: Wzz; cl15801
517418007757	Chain length determinant protein; Region: Wzz; cl15801
517418007758	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
517418007759	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517418007760	Nucleotide binding site [chemical binding]; other site
517418007761	DTAP/Switch II; other site
517418007762	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
517418007763	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
517418007764	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
517418007765	Probable Catalytic site; other site
517418007766	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418007767	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
517418007768	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
517418007769	substrate binding site [chemical binding]; other site
517418007770	active site
517418007771	catalytic residues [active]
517418007772	heterodimer interface [polypeptide binding]; other site
517418007773	UbiA prenyltransferase family; Region: UbiA; cl00337
517418007774	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
517418007775	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
517418007776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418007777	active site
517418007778	phosphorylation site [posttranslational modification]
517418007779	intermolecular recognition site; other site
517418007780	dimerization interface [polypeptide binding]; other site
517418007781	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517418007782	Zn2+ binding site [ion binding]; other site
517418007783	Mg2+ binding site [ion binding]; other site
517418007784	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
517418007785	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517418007786	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517418007787	ligand binding site [chemical binding]; other site
517418007788	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
517418007789	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
517418007790	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
517418007791	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
517418007792	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
517418007793	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
517418007794	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007795	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
517418007796	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517418007797	nucleotide binding region [chemical binding]; other site
517418007798	ATP-binding site [chemical binding]; other site
517418007799	SEC-C motif; Region: SEC-C; pfam02810
517418007800	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
517418007801	active site
517418007802	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418007803	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
517418007804	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
517418007805	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
517418007806	dimerization interface [polypeptide binding]; other site
517418007807	ATP binding site [chemical binding]; other site
517418007808	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
517418007809	dimerization interface [polypeptide binding]; other site
517418007810	ATP binding site [chemical binding]; other site
517418007811	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
517418007812	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517418007813	DNA binding residues [nucleotide binding]
517418007814	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
517418007815	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
517418007816	NADP binding site [chemical binding]; other site
517418007817	homopentamer interface [polypeptide binding]; other site
517418007818	substrate binding site [chemical binding]; other site
517418007819	active site
517418007820	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418007821	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
517418007822	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
517418007823	iron-sulfur cluster [ion binding]; other site
517418007824	[2Fe-2S] cluster binding site [ion binding]; other site
517418007825	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
517418007826	aminodeoxychorismate synthase; Provisional; Region: PRK07508
517418007827	chorismate binding enzyme; Region: Chorismate_bind; cl10555
517418007828	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
517418007829	homodimer interface [polypeptide binding]; other site
517418007830	substrate-cofactor binding pocket; other site
517418007831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517418007832	catalytic residue [active]
517418007833	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
517418007834	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
517418007835	dimer interface [polypeptide binding]; other site
517418007836	catalytic triad [active]
517418007837	peroxidatic and resolving cysteines [active]
517418007838	ATP citrate (pro-S)-lyase; Region: PLN02522
517418007839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007840	CoA-ligase; Region: Ligase_CoA; cl02894
517418007841	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
517418007842	active site
517418007843	oxalacetate binding site [chemical binding]; other site
517418007844	citrylCoA binding site [chemical binding]; other site
517418007845	coenzyme A binding site [chemical binding]; other site
517418007846	catalytic triad [active]
517418007847	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418007848	ATP citrate (pro-S)-lyase; Region: PLN02235
517418007849	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
517418007850	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
517418007851	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
517418007852	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
517418007853	hydrogenase 4 subunit D; Validated; Region: PRK06525
517418007854	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
517418007855	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
517418007856	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
517418007857	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
517418007858	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
517418007859	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
517418007860	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
517418007861	4Fe-4S binding domain; Region: Fer4; cl02805
517418007862	NADH dehydrogenase; Region: NADHdh; cl00469
517418007863	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
517418007864	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
517418007865	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
517418007866	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
517418007867	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
517418007868	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
517418007869	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
517418007870	aromatic arch; other site
517418007871	DCoH dimer interaction site [polypeptide binding]; other site
517418007872	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
517418007873	DCoH tetramer interaction site [polypeptide binding]; other site
517418007874	substrate binding site [chemical binding]; other site
517418007875	TPR repeat; Region: TPR_11; pfam13414
517418007876	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007877	binding surface
517418007878	TPR motif; other site
517418007879	TPR repeat; Region: TPR_11; pfam13414
517418007880	TPR repeat; Region: TPR_11; pfam13414
517418007881	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007882	binding surface
517418007883	TPR motif; other site
517418007884	TPR repeat; Region: TPR_11; pfam13414
517418007885	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007886	binding surface
517418007887	TPR motif; other site
517418007888	TPR repeat; Region: TPR_11; pfam13414
517418007889	TPR repeat; Region: TPR_11; pfam13414
517418007890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007891	binding surface
517418007892	TPR motif; other site
517418007893	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
517418007894	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
517418007895	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
517418007896	TPP-binding site [chemical binding]; other site
517418007897	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
517418007898	Ferrochelatase; Region: Ferrochelatase; pfam00762
517418007899	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
517418007900	C-terminal domain interface [polypeptide binding]; other site
517418007901	active site
517418007902	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
517418007903	active site
517418007904	N-terminal domain interface [polypeptide binding]; other site
517418007905	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517418007906	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
517418007907	active site
517418007908	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
517418007909	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
517418007910	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
517418007911	NeuB family; Region: NeuB; cl00496
517418007912	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
517418007913	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
517418007914	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
517418007915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007916	NAD(P) binding site [chemical binding]; other site
517418007917	active site
517418007918	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517418007919	putative catalytic site [active]
517418007920	putative metal binding site [ion binding]; other site
517418007921	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517418007922	putative catalytic site [active]
517418007923	putative phosphate binding site [ion binding]; other site
517418007924	putative phosphate binding site [ion binding]; other site
517418007925	putative metal binding site [ion binding]; other site
517418007926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418007927	Major Facilitator Superfamily; Region: MFS_1; pfam07690
517418007928	putative substrate translocation pore; other site
517418007929	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
517418007930	putative acyl-acceptor binding pocket; other site
517418007931	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
517418007932	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
517418007933	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
517418007934	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517418007935	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007936	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
517418007937	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
517418007938	active site
517418007939	dimer interface [polypeptide binding]; other site
517418007940	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
517418007941	Ligand Binding Site [chemical binding]; other site
517418007942	Molecular Tunnel; other site
517418007943	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
517418007944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517418007945	Coenzyme A binding pocket [chemical binding]; other site
517418007946	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418007947	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
517418007948	active site
517418007949	catalytic triad [active]
517418007950	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
517418007951	Interdomain contacts; other site
517418007952	Cytokine receptor motif; other site
517418007953	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
517418007954	Interdomain contacts; other site
517418007955	Cytokine receptor motif; other site
517418007956	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
517418007957	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418007958	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
517418007959	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
517418007960	putative oligomer interface [polypeptide binding]; other site
517418007961	putative active site [active]
517418007962	metal binding site [ion binding]; metal-binding site
517418007963	Membrane protein of unknown function; Region: DUF360; cl00850
517418007964	heat shock protein 90; Provisional; Region: PRK05218
517418007965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
517418007966	PspA/IM30 family; Region: PspA_IM30; pfam04012
517418007967	Tir chaperone protein (CesT) family; Region: CesT; cl08444
517418007968	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
517418007969	HSP70 interaction site [polypeptide binding]; other site
517418007970	TPR repeat; Region: TPR_11; pfam13414
517418007971	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418007972	binding surface
517418007973	TPR motif; other site
517418007974	Bacterial SH3 domain; Region: SH3_3; cl02551
517418007975	Oxygen tolerance; Region: BatD; pfam13584
517418007976	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418007977	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
517418007978	TPR repeat; Region: TPR_11; pfam13414
517418007979	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
517418007980	metal ion-dependent adhesion site (MIDAS); other site
517418007981	Protein of unknown function DUF45; Region: DUF45; cl00636
517418007982	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
517418007983	Helix-turn-helix domains; Region: HTH; cl00088
517418007984	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
517418007985	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
517418007986	polyphosphate kinase; Provisional; Region: PRK05443
517418007987	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
517418007988	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
517418007989	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
517418007990	putative domain interface [polypeptide binding]; other site
517418007991	putative active site [active]
517418007992	catalytic site [active]
517418007993	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
517418007994	putative domain interface [polypeptide binding]; other site
517418007995	putative active site [active]
517418007996	catalytic site [active]
517418007997	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
517418007998	FOG: CBS domain [General function prediction only]; Region: COG0517
517418007999	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
517418008000	Protein of unknown function (DUF3623); Region: DUF3623; cl11843
517418008001	UbiA prenyltransferase family; Region: UbiA; cl00337
517418008002	CAAX protease self-immunity; Region: Abi; cl00558
517418008003	Response regulator receiver domain; Region: Response_reg; pfam00072
517418008004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008005	active site
517418008006	phosphorylation site [posttranslational modification]
517418008007	intermolecular recognition site; other site
517418008008	dimerization interface [polypeptide binding]; other site
517418008009	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
517418008010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008011	active site
517418008012	phosphorylation site [posttranslational modification]
517418008013	intermolecular recognition site; other site
517418008014	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418008015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008016	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517418008017	putative active site [active]
517418008018	heme pocket [chemical binding]; other site
517418008019	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008020	putative active site [active]
517418008021	heme pocket [chemical binding]; other site
517418008022	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
517418008023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418008024	dimer interface [polypeptide binding]; other site
517418008025	phosphorylation site [posttranslational modification]
517418008026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418008027	ATP binding site [chemical binding]; other site
517418008028	Mg2+ binding site [ion binding]; other site
517418008029	G-X-G motif; other site
517418008030	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
517418008031	serine acetyltransferase; Provisional; Region: cysE; PRK11132
517418008032	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
517418008033	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
517418008034	trimer interface [polypeptide binding]; other site
517418008035	active site
517418008036	substrate binding site [chemical binding]; other site
517418008037	CoA binding site [chemical binding]; other site
517418008038	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
517418008039	active site
517418008040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418008041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418008042	S-adenosylmethionine binding site [chemical binding]; other site
517418008043	GAF domain; Region: GAF_2; pfam13185
517418008044	GAF domain; Region: GAF; cl15785
517418008045	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
517418008046	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517418008047	metal binding site [ion binding]; metal-binding site
517418008048	active site
517418008049	I-site; other site
517418008050	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
517418008051	Hexamer/Pentamer interface [polypeptide binding]; other site
517418008052	central pore; other site
517418008053	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
517418008054	Hexamer/Pentamer interface [polypeptide binding]; other site
517418008055	central pore; other site
517418008056	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
517418008057	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
517418008058	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517418008059	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
517418008060	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517418008061	DNA binding residues [nucleotide binding]
517418008062	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517418008063	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517418008064	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517418008065	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
517418008066	Cation transport protein; Region: TrkH; cl10514
517418008067	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
517418008068	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
517418008069	Walker A/P-loop; other site
517418008070	ATP binding site [chemical binding]; other site
517418008071	Q-loop/lid; other site
517418008072	ABC transporter signature motif; other site
517418008073	Walker B; other site
517418008074	D-loop; other site
517418008075	H-loop/switch region; other site
517418008076	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
517418008077	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
517418008078	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
517418008079	Response regulator receiver domain; Region: Response_reg; pfam00072
517418008080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008081	active site
517418008082	phosphorylation site [posttranslational modification]
517418008083	intermolecular recognition site; other site
517418008084	dimerization interface [polypeptide binding]; other site
517418008085	Response regulator receiver domain; Region: Response_reg; pfam00072
517418008086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008087	active site
517418008088	phosphorylation site [posttranslational modification]
517418008089	intermolecular recognition site; other site
517418008090	dimerization interface [polypeptide binding]; other site
517418008091	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517418008092	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418008093	Walker A/P-loop; other site
517418008094	ATP binding site [chemical binding]; other site
517418008095	Q-loop/lid; other site
517418008096	ABC transporter signature motif; other site
517418008097	Walker B; other site
517418008098	D-loop; other site
517418008099	H-loop/switch region; other site
517418008100	ribonuclease R; Region: RNase_R; TIGR02063
517418008101	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517418008102	RNB domain; Region: RNB; pfam00773
517418008103	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
517418008104	RNA binding site [nucleotide binding]; other site
517418008105	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
517418008106	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517418008107	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
517418008108	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517418008109	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517418008110	Surface antigen; Region: Bac_surface_Ag; cl03097
517418008111	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
517418008112	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418008113	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
517418008114	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418008115	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
517418008116	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
517418008117	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
517418008118	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
517418008119	DNA polymerase I; Provisional; Region: PRK05755
517418008120	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
517418008121	active site
517418008122	metal binding site 1 [ion binding]; metal-binding site
517418008123	putative 5' ssDNA interaction site; other site
517418008124	metal binding site 3; metal-binding site
517418008125	metal binding site 2 [ion binding]; metal-binding site
517418008126	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
517418008127	putative DNA binding site [nucleotide binding]; other site
517418008128	putative metal binding site [ion binding]; other site
517418008129	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
517418008130	active site
517418008131	catalytic site [active]
517418008132	substrate binding site [chemical binding]; other site
517418008133	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
517418008134	active site
517418008135	DNA binding site [nucleotide binding]
517418008136	catalytic site [active]
517418008137	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
517418008138	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
517418008139	active site
517418008140	catalytic residues [active]
517418008141	metal binding site [ion binding]; metal-binding site
517418008142	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
517418008143	carboxyltransferase (CT) interaction site; other site
517418008144	biotinylation site [posttranslational modification]; other site
517418008145	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
517418008146	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517418008147	ATP-grasp domain; Region: ATP-grasp_4; cl03087
517418008148	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
517418008149	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
517418008150	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
517418008151	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
517418008152	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
517418008153	Ligand Binding Site [chemical binding]; other site
517418008154	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
517418008155	classical (c) SDRs; Region: SDR_c; cd05233
517418008156	NAD(P) binding site [chemical binding]; other site
517418008157	active site
517418008158	RF-1 domain; Region: RF-1; cl02875
517418008159	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
517418008160	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
517418008161	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
517418008162	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517418008163	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
517418008164	active site
517418008165	DNA binding site [nucleotide binding]
517418008166	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
517418008167	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
517418008168	P-loop; other site
517418008169	Magnesium ion binding site [ion binding]; other site
517418008170	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
517418008171	Magnesium ion binding site [ion binding]; other site
517418008172	ParB-like nuclease domain; Region: ParBc; cl02129
517418008173	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
517418008174	dihydrodipicolinate reductase; Provisional; Region: PRK00048
517418008175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418008176	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
517418008177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517418008178	putative substrate translocation pore; other site
517418008179	PUCC protein; Region: PUCC; pfam03209
517418008180	TRL-like protein family; Region: TRL; pfam13146
517418008181	cyclase homology domain; Region: CHD; cd07302
517418008182	nucleotidyl binding site; other site
517418008183	metal binding site [ion binding]; metal-binding site
517418008184	dimer interface [polypeptide binding]; other site
517418008185	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
517418008186	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
517418008187	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
517418008188	active site
517418008189	catalytic site [active]
517418008190	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
517418008191	Malic enzyme, N-terminal domain; Region: malic; pfam00390
517418008192	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
517418008193	putative NAD(P) binding site [chemical binding]; other site
517418008194	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
517418008195	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
517418008196	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
517418008197	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
517418008198	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
517418008199	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
517418008200	prolyl-tRNA synthetase; Provisional; Region: PRK08661
517418008201	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
517418008202	dimer interface [polypeptide binding]; other site
517418008203	motif 1; other site
517418008204	active site
517418008205	motif 2; other site
517418008206	motif 3; other site
517418008207	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
517418008208	anticodon binding site; other site
517418008209	zinc-binding site [ion binding]; other site
517418008210	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
517418008211	active site
517418008212	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517418008213	putative catalytic site [active]
517418008214	putative metal binding site [ion binding]; other site
517418008215	putative phosphate binding site [ion binding]; other site
517418008216	FlgD Ig-like domain; Region: FlgD_ig; cl15790
517418008217	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
517418008218	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
517418008219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517418008220	motif II; other site
517418008221	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
517418008222	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
517418008223	Glycerate kinase family; Region: Gly_kinase; cl00841
517418008224	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418008225	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
517418008226	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418008227	N-terminal plug; other site
517418008228	ligand-binding site [chemical binding]; other site
517418008229	RES domain; Region: RES; cl02411
517418008230	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
517418008231	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
517418008232	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
517418008233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517418008234	CoA-ligase; Region: Ligase_CoA; cl02894
517418008235	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
517418008236	Amidase; Region: Amidase; cl11426
517418008237	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
517418008238	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
517418008239	catalytic residue [active]
517418008240	putative FPP diphosphate  binding site; other site
517418008241	putative FPP binding hydrophobic cleft; other site
517418008242	dimer interface [polypeptide binding]; other site
517418008243	putative IPP diphosphate binding site; other site
517418008244	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
517418008245	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
517418008246	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
517418008247	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
517418008248	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
517418008249	Surface antigen; Region: Bac_surface_Ag; cl03097
517418008250	NAD-dependent deacetylase; Provisional; Region: PRK00481
517418008251	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
517418008252	NAD+ binding site [chemical binding]; other site
517418008253	substrate binding site [chemical binding]; other site
517418008254	Zn binding site [ion binding]; other site
517418008255	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
517418008256	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
517418008257	active site
517418008258	HIGH motif; other site
517418008259	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
517418008260	active site
517418008261	KMSKS motif; other site
517418008262	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
517418008263	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
517418008264	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
517418008265	trimerization site [polypeptide binding]; other site
517418008266	active site
517418008267	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
517418008268	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
517418008269	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
517418008270	catalytic residue [active]
517418008271	Rrf2 family protein; Region: rrf2_super; TIGR00738
517418008272	Helix-turn-helix domains; Region: HTH; cl00088
517418008273	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517418008274	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
517418008275	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
517418008276	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
517418008277	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008278	active site
517418008279	phosphorylation site [posttranslational modification]
517418008280	intermolecular recognition site; other site
517418008281	dimerization interface [polypeptide binding]; other site
517418008282	Helix-turn-helix domains; Region: HTH; cl00088
517418008283	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
517418008284	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
517418008285	DNA binding residues [nucleotide binding]
517418008286	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
517418008287	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
517418008288	NADP binding site [chemical binding]; other site
517418008289	active site
517418008290	putative substrate binding site [chemical binding]; other site
517418008291	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517418008292	structural tetrad; other site
517418008293	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
517418008294	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
517418008295	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418008296	Family description; Region: UvrD_C_2; cl15862
517418008297	Response regulator receiver domain; Region: Response_reg; pfam00072
517418008298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008299	active site
517418008300	phosphorylation site [posttranslational modification]
517418008301	dimerization interface [polypeptide binding]; other site
517418008302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008303	PAS fold; Region: PAS_3; pfam08447
517418008304	putative active site [active]
517418008305	heme pocket [chemical binding]; other site
517418008306	PAS domain S-box; Region: sensory_box; TIGR00229
517418008307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008308	putative active site [active]
517418008309	heme pocket [chemical binding]; other site
517418008310	PAS domain S-box; Region: sensory_box; TIGR00229
517418008311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008312	putative active site [active]
517418008313	heme pocket [chemical binding]; other site
517418008314	PAS domain S-box; Region: sensory_box; TIGR00229
517418008315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008316	putative active site [active]
517418008317	heme pocket [chemical binding]; other site
517418008318	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
517418008319	GAF domain; Region: GAF; cl15785
517418008320	PAS fold; Region: PAS_4; pfam08448
517418008321	PAS domain S-box; Region: sensory_box; TIGR00229
517418008322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418008323	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008324	PAS domain; Region: PAS_9; pfam13426
517418008325	putative active site [active]
517418008326	heme pocket [chemical binding]; other site
517418008327	PAS fold; Region: PAS_4; pfam08448
517418008328	PAS domain S-box; Region: sensory_box; TIGR00229
517418008329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008330	putative active site [active]
517418008331	heme pocket [chemical binding]; other site
517418008332	hypothetical protein; Provisional; Region: PRK13560
517418008333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008334	putative active site [active]
517418008335	heme pocket [chemical binding]; other site
517418008336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008337	putative active site [active]
517418008338	heme pocket [chemical binding]; other site
517418008339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418008340	Histidine kinase; Region: HisKA_2; cl06527
517418008341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418008342	ATP binding site [chemical binding]; other site
517418008343	Mg2+ binding site [ion binding]; other site
517418008344	G-X-G motif; other site
517418008345	Response regulator receiver domain; Region: Response_reg; pfam00072
517418008346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008347	active site
517418008348	phosphorylation site [posttranslational modification]
517418008349	intermolecular recognition site; other site
517418008350	dimerization interface [polypeptide binding]; other site
517418008351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517418008352	PAS domain; Region: PAS_9; pfam13426
517418008353	putative active site [active]
517418008354	heme pocket [chemical binding]; other site
517418008355	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
517418008356	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418008357	dimer interface [polypeptide binding]; other site
517418008358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418008359	ATP binding site [chemical binding]; other site
517418008360	G-X-G motif; other site
517418008361	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
517418008362	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
517418008363	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
517418008364	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517418008365	Protein export membrane protein; Region: SecD_SecF; cl14618
517418008366	Protein export membrane protein; Region: SecD_SecF; cl14618
517418008367	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418008368	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418008369	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418008370	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517418008371	Domain of unknown function DUF302; Region: DUF302; cl01364
517418008372	RNA ligase, T4 RnlA family; Region: RNA_lig_T4_1; TIGR02308
517418008373	Domain of unknown function DUF302; Region: DUF302; cl01364
517418008374	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517418008375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517418008376	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
517418008377	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
517418008378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517418008379	active site
517418008380	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517418008381	binding surface
517418008382	TPR motif; other site
517418008383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517418008384	S-adenosylmethionine binding site [chemical binding]; other site
517418008385	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418008386	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
517418008387	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
517418008388	peptide binding site [polypeptide binding]; other site
517418008389	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353
517418008390	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
517418008391	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
517418008392	putative NAD(P) binding site [chemical binding]; other site
517418008393	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
517418008394	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
517418008395	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
517418008396	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
517418008397	Helix-turn-helix domains; Region: HTH; cl00088
517418008398	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517418008399	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418008400	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
517418008401	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517418008402	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517418008403	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
517418008404	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
517418008405	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517418008406	N-terminal plug; other site
517418008407	ligand-binding site [chemical binding]; other site
517418008408	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418008409	PAS domain; Region: PAS_9; pfam13426
517418008410	PAS domain S-box; Region: sensory_box; TIGR00229
517418008411	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418008412	putative active site [active]
517418008413	heme pocket [chemical binding]; other site
517418008414	PAS domain S-box; Region: sensory_box; TIGR00229
517418008415	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
517418008416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
517418008417	putative active site [active]
517418008418	heme pocket [chemical binding]; other site
517418008419	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517418008420	dimer interface [polypeptide binding]; other site
517418008421	phosphorylation site [posttranslational modification]
517418008422	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517418008423	ATP binding site [chemical binding]; other site
517418008424	Mg2+ binding site [ion binding]; other site
517418008425	G-X-G motif; other site
517418008426	Response regulator receiver domain; Region: Response_reg; pfam00072
517418008427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517418008428	active site
517418008429	phosphorylation site [posttranslational modification]
517418008430	intermolecular recognition site; other site
517418008431	dimerization interface [polypeptide binding]; other site
517418008432	Domain of unknown function DUF77; Region: DUF77; cl00307
517418008433	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
517418008434	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
517418008435	active site
517418008436	membrane protein insertase; Provisional; Region: PRK01318
517418008437	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
517418008438	Haemolytic domain; Region: Haemolytic; cl00506
517418008439	Ribonuclease P; Region: Ribonuclease_P; cl00457
517418008440	Ribosomal protein L34; Region: Ribosomal_L34; cl00370