-- dump date 20140619_041951 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290338000001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000002 D-galactonate transporter; Region: 2A0114; TIGR00893 290338000003 putative substrate translocation pore; other site 290338000004 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 290338000005 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 290338000006 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 290338000007 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290338000008 active site 290338000009 intersubunit interface [polypeptide binding]; other site 290338000010 catalytic residue [active] 290338000011 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 290338000012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000013 putative substrate translocation pore; other site 290338000014 regulatory protein UhpC; Provisional; Region: PRK11663 290338000015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000016 putative substrate translocation pore; other site 290338000017 sensory histidine kinase UhpB; Provisional; Region: PRK11644 290338000018 MASE1; Region: MASE1; pfam05231 290338000019 Histidine kinase; Region: HisKA_3; pfam07730 290338000020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338000021 ATP binding site [chemical binding]; other site 290338000022 Mg2+ binding site [ion binding]; other site 290338000023 G-X-G motif; other site 290338000024 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 290338000025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338000026 active site 290338000027 phosphorylation site [posttranslational modification] 290338000028 intermolecular recognition site; other site 290338000029 dimerization interface [polypeptide binding]; other site 290338000030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338000031 DNA binding residues [nucleotide binding] 290338000032 dimerization interface [polypeptide binding]; other site 290338000033 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 290338000034 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 290338000035 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290338000036 putative valine binding site [chemical binding]; other site 290338000037 dimer interface [polypeptide binding]; other site 290338000038 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 290338000039 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290338000040 PYR/PP interface [polypeptide binding]; other site 290338000041 dimer interface [polypeptide binding]; other site 290338000042 TPP binding site [chemical binding]; other site 290338000043 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290338000044 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290338000045 TPP-binding site [chemical binding]; other site 290338000046 dimer interface [polypeptide binding]; other site 290338000047 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 290338000048 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 290338000049 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 290338000050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000051 putative substrate translocation pore; other site 290338000052 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 290338000053 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 290338000054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338000055 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 290338000056 dimerization interface [polypeptide binding]; other site 290338000057 substrate binding pocket [chemical binding]; other site 290338000058 permease DsdX; Provisional; Region: PRK09921 290338000059 gluconate transporter; Region: gntP; TIGR00791 290338000060 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 290338000061 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 290338000062 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338000063 catalytic residue [active] 290338000064 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 290338000065 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 290338000066 Domain of unknown function (DUF202); Region: DUF202; pfam02656 290338000067 Predicted membrane protein [Function unknown]; Region: COG2149 290338000068 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290338000069 Sulfatase; Region: Sulfatase; pfam00884 290338000070 putative transporter; Provisional; Region: PRK10484 290338000071 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 290338000072 Na binding site [ion binding]; other site 290338000073 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338000074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338000075 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338000076 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290338000077 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 290338000078 NAD binding site [chemical binding]; other site 290338000079 sugar binding site [chemical binding]; other site 290338000080 divalent metal binding site [ion binding]; other site 290338000081 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 290338000082 dimer interface [polypeptide binding]; other site 290338000083 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 290338000084 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 290338000085 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338000086 active site turn [active] 290338000087 phosphorylation site [posttranslational modification] 290338000088 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290338000089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338000090 DNA-binding site [nucleotide binding]; DNA binding site 290338000091 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290338000092 putative transporter; Validated; Region: PRK03818 290338000093 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 290338000094 TrkA-C domain; Region: TrkA_C; pfam02080 290338000095 TrkA-C domain; Region: TrkA_C; pfam02080 290338000096 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 290338000097 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290338000098 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 290338000099 putative dimer interface [polypeptide binding]; other site 290338000100 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290338000101 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 290338000102 putative dimer interface [polypeptide binding]; other site 290338000103 hypothetical protein; Provisional; Region: PRK11616 290338000104 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 290338000105 Protein of unknown function, DUF399; Region: DUF399; pfam04187 290338000106 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 290338000107 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 290338000108 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 290338000109 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290338000110 Uncharacterized conserved protein [Function unknown]; Region: COG3391 290338000111 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 290338000112 sugar phosphate phosphatase; Provisional; Region: PRK10513 290338000113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338000114 active site 290338000115 motif I; other site 290338000116 motif II; other site 290338000117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338000118 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 290338000119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338000120 Mg2+ binding site [ion binding]; other site 290338000121 G-X-G motif; other site 290338000122 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290338000123 anchoring element; other site 290338000124 dimer interface [polypeptide binding]; other site 290338000125 ATP binding site [chemical binding]; other site 290338000126 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290338000127 active site 290338000128 putative metal-binding site [ion binding]; other site 290338000129 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290338000130 recF protein; Region: recf; TIGR00611 290338000131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338000132 Walker A/P-loop; other site 290338000133 ATP binding site [chemical binding]; other site 290338000134 Q-loop/lid; other site 290338000135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338000136 ABC transporter signature motif; other site 290338000137 Walker B; other site 290338000138 D-loop; other site 290338000139 H-loop/switch region; other site 290338000140 DNA polymerase III subunit beta; Validated; Region: PRK05643 290338000141 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290338000142 putative DNA binding surface [nucleotide binding]; other site 290338000143 dimer interface [polypeptide binding]; other site 290338000144 beta-clamp/clamp loader binding surface; other site 290338000145 beta-clamp/translesion DNA polymerase binding surface; other site 290338000146 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 290338000147 DnaA N-terminal domain; Region: DnaA_N; pfam11638 290338000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338000149 Walker A motif; other site 290338000150 ATP binding site [chemical binding]; other site 290338000151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290338000152 Walker B motif; other site 290338000153 arginine finger; other site 290338000154 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290338000155 DnaA box-binding interface [nucleotide binding]; other site 290338000156 ribonuclease P; Reviewed; Region: rnpA; PRK01732 290338000157 membrane protein insertase; Provisional; Region: PRK01318 290338000158 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 290338000159 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 290338000160 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 290338000161 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 290338000162 trmE is a tRNA modification GTPase; Region: trmE; cd04164 290338000163 G1 box; other site 290338000164 GTP/Mg2+ binding site [chemical binding]; other site 290338000165 Switch I region; other site 290338000166 G2 box; other site 290338000167 Switch II region; other site 290338000168 G3 box; other site 290338000169 G4 box; other site 290338000170 G5 box; other site 290338000171 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 290338000172 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 290338000173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000174 putative substrate translocation pore; other site 290338000175 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 290338000176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338000177 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 290338000178 substrate binding pocket [chemical binding]; other site 290338000179 dimerization interface [polypeptide binding]; other site 290338000180 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290338000181 Predicted flavoprotein [General function prediction only]; Region: COG0431 290338000182 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290338000183 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290338000184 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 290338000185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338000186 active site 290338000187 motif I; other site 290338000188 motif II; other site 290338000189 transcriptional regulator PhoU; Provisional; Region: PRK11115 290338000190 PhoU domain; Region: PhoU; pfam01895 290338000191 PhoU domain; Region: PhoU; pfam01895 290338000192 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 290338000193 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 290338000194 Walker A/P-loop; other site 290338000195 ATP binding site [chemical binding]; other site 290338000196 Q-loop/lid; other site 290338000197 ABC transporter signature motif; other site 290338000198 Walker B; other site 290338000199 D-loop; other site 290338000200 H-loop/switch region; other site 290338000201 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 290338000202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338000203 dimer interface [polypeptide binding]; other site 290338000204 conserved gate region; other site 290338000205 putative PBP binding loops; other site 290338000206 ABC-ATPase subunit interface; other site 290338000207 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 290338000208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338000209 dimer interface [polypeptide binding]; other site 290338000210 conserved gate region; other site 290338000211 putative PBP binding loops; other site 290338000212 ABC-ATPase subunit interface; other site 290338000213 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338000214 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290338000215 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290338000216 glutaminase active site [active] 290338000217 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290338000218 dimer interface [polypeptide binding]; other site 290338000219 active site 290338000220 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290338000221 dimer interface [polypeptide binding]; other site 290338000222 active site 290338000223 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 290338000224 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290338000225 Substrate binding site; other site 290338000226 Mg++ binding site; other site 290338000227 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 290338000228 active site 290338000229 substrate binding site [chemical binding]; other site 290338000230 CoA binding site [chemical binding]; other site 290338000231 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 290338000232 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 290338000233 gamma subunit interface [polypeptide binding]; other site 290338000234 epsilon subunit interface [polypeptide binding]; other site 290338000235 LBP interface [polypeptide binding]; other site 290338000236 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290338000237 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290338000238 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290338000239 alpha subunit interaction interface [polypeptide binding]; other site 290338000240 Walker A motif; other site 290338000241 ATP binding site [chemical binding]; other site 290338000242 Walker B motif; other site 290338000243 inhibitor binding site; inhibition site 290338000244 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290338000245 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 290338000246 core domain interface [polypeptide binding]; other site 290338000247 delta subunit interface [polypeptide binding]; other site 290338000248 epsilon subunit interface [polypeptide binding]; other site 290338000249 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290338000250 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290338000251 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290338000252 beta subunit interaction interface [polypeptide binding]; other site 290338000253 Walker A motif; other site 290338000254 ATP binding site [chemical binding]; other site 290338000255 Walker B motif; other site 290338000256 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290338000257 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 290338000258 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 290338000259 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 290338000260 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290338000261 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 290338000262 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 290338000263 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 290338000264 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 290338000265 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 290338000266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338000267 S-adenosylmethionine binding site [chemical binding]; other site 290338000268 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 290338000269 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 290338000270 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 290338000271 FMN-binding protein MioC; Provisional; Region: PRK09004 290338000272 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 290338000273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290338000274 putative DNA binding site [nucleotide binding]; other site 290338000275 putative Zn2+ binding site [ion binding]; other site 290338000276 AsnC family; Region: AsnC_trans_reg; pfam01037 290338000277 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 290338000278 dimer interface [polypeptide binding]; other site 290338000279 active site 290338000280 hypothetical protein; Provisional; Region: yieM; PRK10997 290338000281 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 290338000282 metal ion-dependent adhesion site (MIDAS); other site 290338000283 regulatory ATPase RavA; Provisional; Region: PRK13531 290338000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338000285 Walker A motif; other site 290338000286 ATP binding site [chemical binding]; other site 290338000287 Walker B motif; other site 290338000288 arginine finger; other site 290338000289 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 290338000290 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 290338000291 potassium uptake protein; Region: kup; TIGR00794 290338000292 D-ribose pyranase; Provisional; Region: PRK11797 290338000293 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 290338000294 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338000295 Walker A/P-loop; other site 290338000296 ATP binding site [chemical binding]; other site 290338000297 Q-loop/lid; other site 290338000298 ABC transporter signature motif; other site 290338000299 Walker B; other site 290338000300 D-loop; other site 290338000301 H-loop/switch region; other site 290338000302 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338000303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338000304 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338000305 TM-ABC transporter signature motif; other site 290338000306 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 290338000307 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 290338000308 ligand binding site [chemical binding]; other site 290338000309 dimerization interface [polypeptide binding]; other site 290338000310 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338000311 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290338000312 substrate binding site [chemical binding]; other site 290338000313 dimer interface [polypeptide binding]; other site 290338000314 ATP binding site [chemical binding]; other site 290338000315 transcriptional repressor RbsR; Provisional; Region: PRK10423 290338000316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338000317 DNA binding site [nucleotide binding] 290338000318 domain linker motif; other site 290338000319 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 290338000320 dimerization interface [polypeptide binding]; other site 290338000321 ligand binding site [chemical binding]; other site 290338000322 putative transporter; Provisional; Region: PRK10504 290338000323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000324 putative substrate translocation pore; other site 290338000325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290338000327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338000328 DNA-binding site [nucleotide binding]; DNA binding site 290338000329 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290338000330 transcriptional regulator HdfR; Provisional; Region: PRK03601 290338000331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338000332 LysR substrate binding domain; Region: LysR_substrate; pfam03466 290338000333 dimerization interface [polypeptide binding]; other site 290338000334 hypothetical protein; Provisional; Region: PRK11027 290338000335 putative ATP-dependent protease; Provisional; Region: PRK09862 290338000336 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290338000337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338000338 Walker A motif; other site 290338000339 ATP binding site [chemical binding]; other site 290338000340 Walker B motif; other site 290338000341 arginine finger; other site 290338000342 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290338000343 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 290338000344 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290338000345 PYR/PP interface [polypeptide binding]; other site 290338000346 dimer interface [polypeptide binding]; other site 290338000347 TPP binding site [chemical binding]; other site 290338000348 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290338000349 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290338000350 TPP-binding site [chemical binding]; other site 290338000351 dimer interface [polypeptide binding]; other site 290338000352 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 290338000353 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290338000354 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290338000355 homodimer interface [polypeptide binding]; other site 290338000356 substrate-cofactor binding pocket; other site 290338000357 catalytic residue [active] 290338000358 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 290338000359 threonine dehydratase; Reviewed; Region: PRK09224 290338000360 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 290338000361 tetramer interface [polypeptide binding]; other site 290338000362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338000363 catalytic residue [active] 290338000364 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 290338000365 putative Ile/Val binding site [chemical binding]; other site 290338000366 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 290338000367 putative Ile/Val binding site [chemical binding]; other site 290338000368 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 290338000369 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338000370 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 290338000371 putative dimerization interface [polypeptide binding]; other site 290338000372 ketol-acid reductoisomerase; Validated; Region: PRK05225 290338000373 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 290338000374 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290338000375 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290338000376 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 290338000377 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 290338000378 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 290338000379 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290338000380 ligand binding site [chemical binding]; other site 290338000381 flexible hinge region; other site 290338000382 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 290338000383 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 290338000384 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 290338000385 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 290338000386 Part of AAA domain; Region: AAA_19; pfam13245 290338000387 Family description; Region: UvrD_C_2; pfam13538 290338000388 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 290338000389 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290338000390 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 290338000391 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290338000392 ATP binding site [chemical binding]; other site 290338000393 Mg++ binding site [ion binding]; other site 290338000394 motif III; other site 290338000395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338000396 nucleotide binding region [chemical binding]; other site 290338000397 ATP-binding site [chemical binding]; other site 290338000398 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290338000399 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290338000400 catalytic residues [active] 290338000401 transcription termination factor Rho; Provisional; Region: rho; PRK09376 290338000402 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 290338000403 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 290338000404 RNA binding site [nucleotide binding]; other site 290338000405 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 290338000406 multimer interface [polypeptide binding]; other site 290338000407 Walker A motif; other site 290338000408 ATP binding site [chemical binding]; other site 290338000409 Walker B motif; other site 290338000410 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 290338000411 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 290338000412 Mg++ binding site [ion binding]; other site 290338000413 putative catalytic motif [active] 290338000414 substrate binding site [chemical binding]; other site 290338000415 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 290338000416 Chain length determinant protein; Region: Wzz; pfam02706 290338000417 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 290338000418 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 290338000419 active site 290338000420 homodimer interface [polypeptide binding]; other site 290338000421 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 290338000422 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290338000423 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290338000424 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290338000425 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 290338000426 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290338000427 NAD binding site [chemical binding]; other site 290338000428 substrate binding site [chemical binding]; other site 290338000429 homodimer interface [polypeptide binding]; other site 290338000430 active site 290338000431 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290338000432 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290338000433 substrate binding site; other site 290338000434 tetramer interface; other site 290338000435 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 290338000436 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290338000437 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290338000438 inhibitor-cofactor binding pocket; inhibition site 290338000439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338000440 catalytic residue [active] 290338000441 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 290338000442 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 290338000443 putative common antigen polymerase; Provisional; Region: PRK02975 290338000444 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290338000445 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290338000446 putative transport protein YifK; Provisional; Region: PRK10746 290338000447 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 290338000448 HemY protein N-terminus; Region: HemY_N; pfam07219 290338000449 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 290338000450 HemX; Region: HemX; pfam04375 290338000451 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 290338000452 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290338000453 active site 290338000454 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290338000455 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 290338000456 domain interfaces; other site 290338000457 active site 290338000458 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 290338000459 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 290338000460 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 290338000461 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 290338000462 putative iron binding site [ion binding]; other site 290338000463 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 290338000464 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290338000465 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290338000466 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290338000467 hypothetical protein; Provisional; Region: PRK10963 290338000468 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 290338000469 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290338000470 active site 290338000471 DNA binding site [nucleotide binding] 290338000472 Int/Topo IB signature motif; other site 290338000473 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 290338000474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338000475 motif II; other site 290338000476 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 290338000477 Part of AAA domain; Region: AAA_19; pfam13245 290338000478 Family description; Region: UvrD_C_2; pfam13538 290338000479 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290338000480 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 290338000481 Cl binding site [ion binding]; other site 290338000482 oligomer interface [polypeptide binding]; other site 290338000483 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 290338000484 EamA-like transporter family; Region: EamA; cl17759 290338000485 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290338000486 CoenzymeA binding site [chemical binding]; other site 290338000487 subunit interaction site [polypeptide binding]; other site 290338000488 PHB binding site; other site 290338000489 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 290338000490 dimerization interface [polypeptide binding]; other site 290338000491 substrate binding site [chemical binding]; other site 290338000492 active site 290338000493 calcium binding site [ion binding]; other site 290338000494 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 290338000495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338000496 ATP binding site [chemical binding]; other site 290338000497 putative Mg++ binding site [ion binding]; other site 290338000498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338000499 nucleotide binding region [chemical binding]; other site 290338000500 ATP-binding site [chemical binding]; other site 290338000501 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 290338000502 Helicase and RNase D C-terminal; Region: HRDC; smart00341 290338000503 threonine efflux system; Provisional; Region: PRK10229 290338000504 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 290338000505 lysophospholipase L2; Provisional; Region: PRK10749 290338000506 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290338000507 putative hydrolase; Provisional; Region: PRK10976 290338000508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338000509 active site 290338000510 motif I; other site 290338000511 motif II; other site 290338000512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338000513 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290338000514 EamA-like transporter family; Region: EamA; pfam00892 290338000515 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 290338000516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338000517 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 290338000518 putative dimerization interface [polypeptide binding]; other site 290338000519 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 290338000520 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 290338000521 THF binding site; other site 290338000522 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290338000523 substrate binding site [chemical binding]; other site 290338000524 THF binding site; other site 290338000525 zinc-binding site [ion binding]; other site 290338000526 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290338000527 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290338000528 uridine phosphorylase; Provisional; Region: PRK11178 290338000529 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 290338000530 DNA recombination protein RmuC; Provisional; Region: PRK10361 290338000531 RmuC family; Region: RmuC; pfam02646 290338000532 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 290338000533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338000534 S-adenosylmethionine binding site [chemical binding]; other site 290338000535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 290338000536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 290338000537 SCP-2 sterol transfer family; Region: SCP2; pfam02036 290338000538 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 290338000539 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 290338000540 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 290338000541 sec-independent translocase; Provisional; Region: PRK01770 290338000542 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 290338000543 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290338000544 active site 290338000545 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 290338000546 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 290338000547 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 290338000548 FMN reductase; Validated; Region: fre; PRK08051 290338000549 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 290338000550 FAD binding pocket [chemical binding]; other site 290338000551 FAD binding motif [chemical binding]; other site 290338000552 phosphate binding motif [ion binding]; other site 290338000553 beta-alpha-beta structure motif; other site 290338000554 NAD binding pocket [chemical binding]; other site 290338000555 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 290338000556 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290338000557 dimer interface [polypeptide binding]; other site 290338000558 active site 290338000559 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 290338000560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290338000561 substrate binding site [chemical binding]; other site 290338000562 oxyanion hole (OAH) forming residues; other site 290338000563 trimer interface [polypeptide binding]; other site 290338000564 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290338000565 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290338000566 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290338000567 proline dipeptidase; Provisional; Region: PRK13607 290338000568 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290338000569 active site 290338000570 hypothetical protein; Provisional; Region: PRK11568 290338000571 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 290338000572 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 290338000573 potassium transporter; Provisional; Region: PRK10750 290338000574 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290338000575 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 290338000576 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 290338000577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000578 putative substrate translocation pore; other site 290338000579 lipoprotein; Provisional; Region: PRK10759 290338000580 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 290338000581 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 290338000582 domain interface [polypeptide binding]; other site 290338000583 putative active site [active] 290338000584 catalytic site [active] 290338000585 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 290338000586 domain interface [polypeptide binding]; other site 290338000587 putative active site [active] 290338000588 catalytic site [active] 290338000589 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 290338000590 CoA binding domain; Region: CoA_binding_2; pfam13380 290338000591 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 290338000592 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 290338000593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290338000594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338000595 Coenzyme A binding pocket [chemical binding]; other site 290338000596 Uncharacterized conserved protein [Function unknown]; Region: COG3148 290338000597 thioredoxin 2; Provisional; Region: PRK10996 290338000598 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 290338000599 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290338000600 catalytic residues [active] 290338000601 putative methyltransferase; Provisional; Region: PRK10864 290338000602 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 290338000603 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290338000604 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 290338000605 ligand binding site [chemical binding]; other site 290338000606 active site 290338000607 UGI interface [polypeptide binding]; other site 290338000608 catalytic site [active] 290338000609 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 290338000610 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 290338000611 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290338000612 ATP binding site [chemical binding]; other site 290338000613 Mg++ binding site [ion binding]; other site 290338000614 motif III; other site 290338000615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338000616 nucleotide binding region [chemical binding]; other site 290338000617 ATP-binding site [chemical binding]; other site 290338000618 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 290338000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338000620 S-adenosylmethionine binding site [chemical binding]; other site 290338000621 L-aspartate oxidase; Provisional; Region: PRK09077 290338000622 L-aspartate oxidase; Provisional; Region: PRK06175 290338000623 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290338000624 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 290338000625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338000626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290338000627 DNA binding residues [nucleotide binding] 290338000628 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 290338000629 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 290338000630 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 290338000631 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 290338000632 anti-sigma E factor; Provisional; Region: rseB; PRK09455 290338000633 SoxR reducing system protein RseC; Provisional; Region: PRK10862 290338000634 GTP-binding protein LepA; Provisional; Region: PRK05433 290338000635 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290338000636 G1 box; other site 290338000637 putative GEF interaction site [polypeptide binding]; other site 290338000638 GTP/Mg2+ binding site [chemical binding]; other site 290338000639 Switch I region; other site 290338000640 G2 box; other site 290338000641 G3 box; other site 290338000642 Switch II region; other site 290338000643 G4 box; other site 290338000644 G5 box; other site 290338000645 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 290338000646 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290338000647 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290338000648 signal peptidase I; Provisional; Region: PRK10861 290338000649 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290338000650 Catalytic site [active] 290338000651 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290338000652 GTPase Era; Reviewed; Region: era; PRK00089 290338000653 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 290338000654 G1 box; other site 290338000655 GTP/Mg2+ binding site [chemical binding]; other site 290338000656 Switch I region; other site 290338000657 G2 box; other site 290338000658 Switch II region; other site 290338000659 G3 box; other site 290338000660 G4 box; other site 290338000661 G5 box; other site 290338000662 KH domain; Region: KH_2; pfam07650 290338000663 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290338000664 Recombination protein O N terminal; Region: RecO_N; pfam11967 290338000665 Recombination protein O C terminal; Region: RecO_C; pfam02565 290338000666 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 290338000667 active site 290338000668 hydrophilic channel; other site 290338000669 dimerization interface [polypeptide binding]; other site 290338000670 catalytic residues [active] 290338000671 active site lid [active] 290338000672 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 290338000673 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 290338000674 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338000675 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 290338000676 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338000677 putative active site [active] 290338000678 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 290338000679 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 290338000680 putative active site [active] 290338000681 hypothetical protein; Provisional; Region: PRK11590 290338000682 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290338000683 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290338000684 nucleoside/Zn binding site; other site 290338000685 dimer interface [polypeptide binding]; other site 290338000686 catalytic motif [active] 290338000687 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 290338000688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338000689 substrate binding pocket [chemical binding]; other site 290338000690 membrane-bound complex binding site; other site 290338000691 hinge residues; other site 290338000692 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338000693 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338000694 catalytic residue [active] 290338000695 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 290338000696 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290338000697 dimerization interface [polypeptide binding]; other site 290338000698 ATP binding site [chemical binding]; other site 290338000699 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 290338000700 dimerization interface [polypeptide binding]; other site 290338000701 ATP binding site [chemical binding]; other site 290338000702 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290338000703 putative active site [active] 290338000704 catalytic triad [active] 290338000705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290338000706 HAMP domain; Region: HAMP; pfam00672 290338000707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338000708 dimer interface [polypeptide binding]; other site 290338000709 phosphorylation site [posttranslational modification] 290338000710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338000711 ATP binding site [chemical binding]; other site 290338000712 Mg2+ binding site [ion binding]; other site 290338000713 G-X-G motif; other site 290338000714 hypothetical protein; Provisional; Region: PRK10722 290338000715 response regulator GlrR; Provisional; Region: PRK15115 290338000716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338000717 active site 290338000718 phosphorylation site [posttranslational modification] 290338000719 intermolecular recognition site; other site 290338000720 dimerization interface [polypeptide binding]; other site 290338000721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338000722 Walker A motif; other site 290338000723 ATP binding site [chemical binding]; other site 290338000724 Walker B motif; other site 290338000725 arginine finger; other site 290338000726 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 290338000727 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290338000728 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 290338000729 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 290338000730 heme-binding site [chemical binding]; other site 290338000731 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 290338000732 FAD binding pocket [chemical binding]; other site 290338000733 FAD binding motif [chemical binding]; other site 290338000734 phosphate binding motif [ion binding]; other site 290338000735 beta-alpha-beta structure motif; other site 290338000736 NAD binding pocket [chemical binding]; other site 290338000737 Heme binding pocket [chemical binding]; other site 290338000738 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290338000739 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290338000740 dimer interface [polypeptide binding]; other site 290338000741 active site 290338000742 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290338000743 folate binding site [chemical binding]; other site 290338000744 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290338000745 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290338000746 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338000747 nucleotide binding site [chemical binding]; other site 290338000748 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290338000749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338000750 binding surface 290338000751 TPR motif; other site 290338000752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338000753 binding surface 290338000754 TPR motif; other site 290338000755 TPR repeat; Region: TPR_11; pfam13414 290338000756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338000757 binding surface 290338000758 TPR motif; other site 290338000759 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 290338000760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000761 putative substrate translocation pore; other site 290338000762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000763 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 290338000764 active site 290338000765 catalytic residues [active] 290338000766 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 290338000767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000768 putative substrate translocation pore; other site 290338000769 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 290338000770 PRD domain; Region: PRD; pfam00874 290338000771 PRD domain; Region: PRD; pfam00874 290338000772 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 290338000773 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 290338000774 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290338000775 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290338000776 active site 290338000777 dimerization interface [polypeptide binding]; other site 290338000778 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 290338000779 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 290338000780 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 290338000781 Rrf2 family protein; Region: rrf2_super; TIGR00738 290338000782 cysteine desulfurase; Provisional; Region: PRK14012 290338000783 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290338000784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338000785 catalytic residue [active] 290338000786 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290338000787 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290338000788 trimerization site [polypeptide binding]; other site 290338000789 active site 290338000790 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 290338000791 co-chaperone HscB; Provisional; Region: hscB; PRK05014 290338000792 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290338000793 HSP70 interaction site [polypeptide binding]; other site 290338000794 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 290338000795 chaperone protein HscA; Provisional; Region: hscA; PRK05183 290338000796 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 290338000797 nucleotide binding site [chemical binding]; other site 290338000798 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290338000799 SBD interface [polypeptide binding]; other site 290338000800 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290338000801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290338000802 catalytic loop [active] 290338000803 iron binding site [ion binding]; other site 290338000804 hypothetical protein; Provisional; Region: PRK10721 290338000805 aminopeptidase B; Provisional; Region: PRK05015 290338000806 Peptidase; Region: DUF3663; pfam12404 290338000807 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290338000808 interface (dimer of trimers) [polypeptide binding]; other site 290338000809 Substrate-binding/catalytic site; other site 290338000810 Zn-binding sites [ion binding]; other site 290338000811 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 290338000812 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 290338000813 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290338000814 active site residue [active] 290338000815 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290338000816 active site residue [active] 290338000817 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 290338000818 MG2 domain; Region: A2M_N; pfam01835 290338000819 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 290338000820 surface patch; other site 290338000821 thioester region; other site 290338000822 penicillin-binding protein 1C; Provisional; Region: PRK11240 290338000823 Transglycosylase; Region: Transgly; pfam00912 290338000824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290338000825 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 290338000826 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290338000827 active site 290338000828 multimer interface [polypeptide binding]; other site 290338000829 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 290338000830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338000831 FeS/SAM binding site; other site 290338000832 cytoskeletal protein RodZ; Provisional; Region: PRK10856 290338000833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338000834 non-specific DNA binding site [nucleotide binding]; other site 290338000835 salt bridge; other site 290338000836 sequence-specific DNA binding site [nucleotide binding]; other site 290338000837 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 290338000838 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 290338000839 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290338000840 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290338000841 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 290338000842 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 290338000843 dimer interface [polypeptide binding]; other site 290338000844 motif 1; other site 290338000845 active site 290338000846 motif 2; other site 290338000847 motif 3; other site 290338000848 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290338000849 anticodon binding site; other site 290338000850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 290338000851 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 290338000852 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 290338000853 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 290338000854 Trp docking motif [polypeptide binding]; other site 290338000855 GTP-binding protein Der; Reviewed; Region: PRK00093 290338000856 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290338000857 G1 box; other site 290338000858 GTP/Mg2+ binding site [chemical binding]; other site 290338000859 Switch I region; other site 290338000860 G2 box; other site 290338000861 Switch II region; other site 290338000862 G3 box; other site 290338000863 G4 box; other site 290338000864 G5 box; other site 290338000865 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290338000866 G1 box; other site 290338000867 GTP/Mg2+ binding site [chemical binding]; other site 290338000868 Switch I region; other site 290338000869 G2 box; other site 290338000870 G3 box; other site 290338000871 Switch II region; other site 290338000872 G4 box; other site 290338000873 G5 box; other site 290338000874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338000875 putative substrate translocation pore; other site 290338000876 POT family; Region: PTR2; cl17359 290338000877 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 290338000878 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 290338000879 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290338000880 generic binding surface II; other site 290338000881 generic binding surface I; other site 290338000882 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290338000883 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290338000884 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 290338000885 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290338000886 active site 290338000887 GMP synthase; Reviewed; Region: guaA; PRK00074 290338000888 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290338000889 AMP/PPi binding site [chemical binding]; other site 290338000890 candidate oxyanion hole; other site 290338000891 catalytic triad [active] 290338000892 potential glutamine specificity residues [chemical binding]; other site 290338000893 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290338000894 ATP Binding subdomain [chemical binding]; other site 290338000895 Ligand Binding sites [chemical binding]; other site 290338000896 Dimerization subdomain; other site 290338000897 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 290338000898 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 290338000899 MASE1; Region: MASE1; pfam05231 290338000900 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338000901 diguanylate cyclase; Region: GGDEF; smart00267 290338000902 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338000903 exopolyphosphatase; Provisional; Region: PRK10854 290338000904 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338000905 nucleotide binding site [chemical binding]; other site 290338000906 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 290338000907 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290338000908 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290338000909 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 290338000910 putative active site [active] 290338000911 catalytic site [active] 290338000912 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 290338000913 domain interface [polypeptide binding]; other site 290338000914 active site 290338000915 catalytic site [active] 290338000916 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290338000917 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290338000918 active site 290338000919 substrate binding site [chemical binding]; other site 290338000920 cosubstrate binding site; other site 290338000921 catalytic site [active] 290338000922 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290338000923 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290338000924 dimerization interface [polypeptide binding]; other site 290338000925 putative ATP binding site [chemical binding]; other site 290338000926 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 290338000927 beta-galactosidase; Region: BGL; TIGR03356 290338000928 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338000929 active site 290338000930 uracil transporter; Provisional; Region: PRK10720 290338000931 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 290338000932 DNA replication initiation factor; Provisional; Region: PRK08084 290338000933 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 290338000934 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290338000935 interface (dimer of trimers) [polypeptide binding]; other site 290338000936 Substrate-binding/catalytic site; other site 290338000937 Zn-binding sites [ion binding]; other site 290338000938 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 290338000939 active site 290338000940 dimer interface [polypeptide binding]; other site 290338000941 catalytic nucleophile [active] 290338000942 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290338000943 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290338000944 Homeodomain-like domain; Region: HTH_23; pfam13384 290338000945 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 290338000946 ArsC family; Region: ArsC; pfam03960 290338000947 catalytic residues [active] 290338000948 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 290338000949 Peptidase family M48; Region: Peptidase_M48; cl12018 290338000950 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290338000951 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290338000952 Nucleoside recognition; Region: Gate; pfam07670 290338000953 hypothetical protein; Provisional; Region: PRK10519 290338000954 isoaspartyl dipeptidase; Provisional; Region: PRK10657 290338000955 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290338000956 active site 290338000957 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290338000958 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290338000959 catalytic triad [active] 290338000960 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290338000961 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290338000962 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290338000963 dihydrodipicolinate synthase; Region: dapA; TIGR00674 290338000964 dimer interface [polypeptide binding]; other site 290338000965 active site 290338000966 catalytic residue [active] 290338000967 lipoprotein; Provisional; Region: PRK11679 290338000968 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 290338000969 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 290338000970 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 290338000971 ATP binding site [chemical binding]; other site 290338000972 active site 290338000973 substrate binding site [chemical binding]; other site 290338000974 Predicted metalloprotease [General function prediction only]; Region: COG2321 290338000975 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 290338000976 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 290338000977 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 290338000978 Helicase; Region: Helicase_RecD; pfam05127 290338000979 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 290338000980 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 290338000981 putative hydrolase; Provisional; Region: PRK11460 290338000982 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 290338000983 hypothetical protein; Provisional; Region: PRK13664 290338000984 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 290338000985 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 290338000986 metal binding site [ion binding]; metal-binding site 290338000987 dimer interface [polypeptide binding]; other site 290338000988 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 290338000989 ArsC family; Region: ArsC; pfam03960 290338000990 putative catalytic residues [active] 290338000991 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 290338000992 Protein export membrane protein; Region: SecD_SecF; cl14618 290338000993 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 290338000994 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 290338000995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338000996 dimerization interface [polypeptide binding]; other site 290338000997 Histidine kinase; Region: HisKA_3; pfam07730 290338000998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338000999 ATP binding site [chemical binding]; other site 290338001000 Mg2+ binding site [ion binding]; other site 290338001001 G-X-G motif; other site 290338001002 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 290338001003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290338001004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338001005 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 290338001006 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290338001007 dimer interface [polypeptide binding]; other site 290338001008 ADP-ribose binding site [chemical binding]; other site 290338001009 active site 290338001010 nudix motif; other site 290338001011 metal binding site [ion binding]; metal-binding site 290338001012 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 290338001013 transketolase; Reviewed; Region: PRK12753 290338001014 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290338001015 TPP-binding site [chemical binding]; other site 290338001016 dimer interface [polypeptide binding]; other site 290338001017 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290338001018 PYR/PP interface [polypeptide binding]; other site 290338001019 dimer interface [polypeptide binding]; other site 290338001020 TPP binding site [chemical binding]; other site 290338001021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290338001022 transaldolase-like protein; Provisional; Region: PTZ00411 290338001023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 290338001024 active site 290338001025 dimer interface [polypeptide binding]; other site 290338001026 catalytic residue [active] 290338001027 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 290338001028 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290338001029 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 290338001030 putative NAD(P) binding site [chemical binding]; other site 290338001031 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 290338001032 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 290338001033 putative hexamer interface [polypeptide binding]; other site 290338001034 putative hexagonal pore; other site 290338001035 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290338001036 G1 box; other site 290338001037 GTP/Mg2+ binding site [chemical binding]; other site 290338001038 G2 box; other site 290338001039 Switch I region; other site 290338001040 G3 box; other site 290338001041 Switch II region; other site 290338001042 G4 box; other site 290338001043 G5 box; other site 290338001044 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 290338001045 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 290338001046 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 290338001047 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 290338001048 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 290338001049 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 290338001050 Hexamer interface [polypeptide binding]; other site 290338001051 Hexagonal pore residue; other site 290338001052 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 290338001053 Hexamer/Pentamer interface [polypeptide binding]; other site 290338001054 central pore; other site 290338001055 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 290338001056 putative catalytic cysteine [active] 290338001057 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 290338001058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338001059 nucleotide binding site [chemical binding]; other site 290338001060 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 290338001061 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 290338001062 active site 290338001063 metal binding site [ion binding]; metal-binding site 290338001064 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 290338001065 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 290338001066 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 290338001067 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 290338001068 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 290338001069 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 290338001070 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 290338001071 putative hexamer interface [polypeptide binding]; other site 290338001072 putative hexagonal pore; other site 290338001073 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 290338001074 putative hexamer interface [polypeptide binding]; other site 290338001075 putative hexagonal pore; other site 290338001076 carboxysome structural protein EutK; Provisional; Region: PRK15466 290338001077 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 290338001078 Hexamer interface [polypeptide binding]; other site 290338001079 Hexagonal pore residue; other site 290338001080 transcriptional regulator EutR; Provisional; Region: PRK10130 290338001081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338001082 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338001083 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 290338001084 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 290338001085 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 290338001086 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290338001087 active site 290338001088 metal binding site [ion binding]; metal-binding site 290338001089 putative acetyltransferase; Provisional; Region: PRK03624 290338001090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338001091 Coenzyme A binding pocket [chemical binding]; other site 290338001092 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 290338001093 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 290338001094 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 290338001095 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 290338001096 putative periplasmic esterase; Provisional; Region: PRK03642 290338001097 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290338001098 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 290338001099 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338001100 active site turn [active] 290338001101 phosphorylation site [posttranslational modification] 290338001102 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290338001103 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 290338001104 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 290338001105 putative active site [active] 290338001106 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 290338001107 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338001108 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338001109 trimer interface [polypeptide binding]; other site 290338001110 eyelet of channel; other site 290338001111 transcriptional regulator MurR; Provisional; Region: PRK15482 290338001112 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338001113 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338001114 putative active site [active] 290338001115 short chain dehydrogenase; Provisional; Region: PRK08226 290338001116 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 290338001117 NAD binding site [chemical binding]; other site 290338001118 homotetramer interface [polypeptide binding]; other site 290338001119 homodimer interface [polypeptide binding]; other site 290338001120 active site 290338001121 thiosulfate transporter subunit; Provisional; Region: PRK10852 290338001122 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290338001123 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290338001124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338001125 dimer interface [polypeptide binding]; other site 290338001126 conserved gate region; other site 290338001127 putative PBP binding loops; other site 290338001128 ABC-ATPase subunit interface; other site 290338001129 sulfate transport protein; Provisional; Region: cysT; CHL00187 290338001130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338001131 dimer interface [polypeptide binding]; other site 290338001132 conserved gate region; other site 290338001133 putative PBP binding loops; other site 290338001134 ABC-ATPase subunit interface; other site 290338001135 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 290338001136 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 290338001137 Walker A/P-loop; other site 290338001138 ATP binding site [chemical binding]; other site 290338001139 Q-loop/lid; other site 290338001140 ABC transporter signature motif; other site 290338001141 Walker B; other site 290338001142 D-loop; other site 290338001143 H-loop/switch region; other site 290338001144 TOBE-like domain; Region: TOBE_3; pfam12857 290338001145 cysteine synthase B; Region: cysM; TIGR01138 290338001146 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290338001147 dimer interface [polypeptide binding]; other site 290338001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338001149 catalytic residue [active] 290338001150 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290338001151 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290338001152 catalytic triad [active] 290338001153 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 290338001154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338001155 DNA-binding site [nucleotide binding]; DNA binding site 290338001156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338001157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338001158 homodimer interface [polypeptide binding]; other site 290338001159 catalytic residue [active] 290338001160 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 290338001161 dimer interface [polypeptide binding]; other site 290338001162 pyridoxamine kinase; Validated; Region: PRK05756 290338001163 pyridoxal binding site [chemical binding]; other site 290338001164 ATP binding site [chemical binding]; other site 290338001165 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 290338001166 HPr interaction site; other site 290338001167 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290338001168 active site 290338001169 phosphorylation site [posttranslational modification] 290338001170 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 290338001171 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290338001172 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290338001173 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290338001174 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290338001175 dimerization domain swap beta strand [polypeptide binding]; other site 290338001176 regulatory protein interface [polypeptide binding]; other site 290338001177 active site 290338001178 regulatory phosphorylation site [posttranslational modification]; other site 290338001179 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290338001180 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290338001181 dimer interface [polypeptide binding]; other site 290338001182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338001183 catalytic residue [active] 290338001184 putative sulfate transport protein CysZ; Validated; Region: PRK04949 290338001185 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 290338001186 cell division protein ZipA; Provisional; Region: PRK03427 290338001187 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 290338001188 FtsZ protein binding site [polypeptide binding]; other site 290338001189 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290338001190 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290338001191 nucleotide binding pocket [chemical binding]; other site 290338001192 K-X-D-G motif; other site 290338001193 catalytic site [active] 290338001194 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290338001195 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290338001196 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290338001197 Dimer interface [polypeptide binding]; other site 290338001198 BRCT sequence motif; other site 290338001199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 290338001200 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 290338001201 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 290338001202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338001203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338001204 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 290338001205 putative dimerization interface [polypeptide binding]; other site 290338001206 purine nucleoside phosphorylase; Provisional; Region: PRK08202 290338001207 nucleoside transporter; Region: 2A0110; TIGR00889 290338001208 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290338001209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338001210 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 290338001211 putative dimerization interface [polypeptide binding]; other site 290338001212 putative substrate binding pocket [chemical binding]; other site 290338001213 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290338001214 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290338001215 active site 290338001216 HIGH motif; other site 290338001217 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290338001218 active site 290338001219 KMSKS motif; other site 290338001220 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 290338001221 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 290338001222 MASE1; Region: MASE1; pfam05231 290338001223 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338001224 diguanylate cyclase; Region: GGDEF; smart00267 290338001225 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338001226 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 290338001227 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 290338001228 Nucleoside recognition; Region: Gate; pfam07670 290338001229 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 290338001230 manganese transport protein MntH; Reviewed; Region: PRK00701 290338001231 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 290338001232 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 290338001233 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338001234 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338001235 active site 290338001236 catalytic tetrad [active] 290338001237 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 290338001238 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 290338001239 dimer interface [polypeptide binding]; other site 290338001240 PYR/PP interface [polypeptide binding]; other site 290338001241 TPP binding site [chemical binding]; other site 290338001242 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290338001243 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 290338001244 TPP-binding site [chemical binding]; other site 290338001245 dimer interface [polypeptide binding]; other site 290338001246 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 290338001247 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 290338001248 Cl- selectivity filter; other site 290338001249 Cl- binding residues [ion binding]; other site 290338001250 pore gating glutamate residue; other site 290338001251 dimer interface [polypeptide binding]; other site 290338001252 glucokinase; Provisional; Region: glk; PRK00292 290338001253 glucokinase, proteobacterial type; Region: glk; TIGR00749 290338001254 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290338001255 active site 290338001256 P-loop; other site 290338001257 phosphorylation site [posttranslational modification] 290338001258 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290338001259 aminopeptidase; Provisional; Region: PRK09795 290338001260 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290338001261 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 290338001262 active site 290338001263 exoaminopeptidase; Provisional; Region: PRK09961 290338001264 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 290338001265 metal binding site [ion binding]; metal-binding site 290338001266 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290338001267 dimerization domain swap beta strand [polypeptide binding]; other site 290338001268 regulatory protein interface [polypeptide binding]; other site 290338001269 active site 290338001270 regulatory phosphorylation site [posttranslational modification]; other site 290338001271 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 290338001272 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290338001273 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290338001274 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290338001275 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338001276 active site 290338001277 phosphorylation site [posttranslational modification] 290338001278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338001279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338001280 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 290338001281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338001282 active site 290338001283 phosphorylation site [posttranslational modification] 290338001284 intermolecular recognition site; other site 290338001285 dimerization interface [polypeptide binding]; other site 290338001286 LytTr DNA-binding domain; Region: LytTR; pfam04397 290338001287 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 290338001288 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 290338001289 GAF domain; Region: GAF; pfam01590 290338001290 Histidine kinase; Region: His_kinase; pfam06580 290338001291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338001292 ATP binding site [chemical binding]; other site 290338001293 Mg2+ binding site [ion binding]; other site 290338001294 G-X-G motif; other site 290338001295 aminotransferase; Validated; Region: PRK08175 290338001296 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338001297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338001298 homodimer interface [polypeptide binding]; other site 290338001299 catalytic residue [active] 290338001300 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 290338001301 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290338001302 putative acyl-acceptor binding pocket; other site 290338001303 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 290338001304 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 290338001305 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290338001306 Autotransporter beta-domain; Region: Autotransporter; pfam03797 290338001307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338001308 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 290338001309 DNA binding residues [nucleotide binding] 290338001310 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290338001311 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290338001312 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338001313 Predicted membrane protein [Function unknown]; Region: COG2259 290338001314 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290338001315 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290338001316 active site 290338001317 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 290338001318 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 290338001319 Isochorismatase family; Region: Isochorismatase; pfam00857 290338001320 catalytic triad [active] 290338001321 dimer interface [polypeptide binding]; other site 290338001322 conserved cis-peptide bond; other site 290338001323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338001324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338001325 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290338001326 putative effector binding pocket; other site 290338001327 dimerization interface [polypeptide binding]; other site 290338001328 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 290338001329 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290338001330 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290338001331 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 290338001332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338001333 putative active site [active] 290338001334 heme pocket [chemical binding]; other site 290338001335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338001336 putative active site [active] 290338001337 heme pocket [chemical binding]; other site 290338001338 GAF domain; Region: GAF; cl17456 290338001339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338001340 metal binding site [ion binding]; metal-binding site 290338001341 active site 290338001342 I-site; other site 290338001343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338001344 Cache domain; Region: Cache_1; pfam02743 290338001345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338001346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338001347 metal binding site [ion binding]; metal-binding site 290338001348 active site 290338001349 I-site; other site 290338001350 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 290338001351 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 290338001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338001353 Transmembrane secretion effector; Region: MFS_3; pfam05977 290338001354 putative substrate translocation pore; other site 290338001355 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 290338001356 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 290338001357 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 290338001358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 290338001359 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 290338001360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290338001361 dimer interface [polypeptide binding]; other site 290338001362 active site 290338001363 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 290338001364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290338001365 substrate binding site [chemical binding]; other site 290338001366 oxyanion hole (OAH) forming residues; other site 290338001367 trimer interface [polypeptide binding]; other site 290338001368 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290338001369 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290338001370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290338001371 catalytic core [active] 290338001372 hypothetical protein; Provisional; Region: PRK04946 290338001373 Smr domain; Region: Smr; pfam01713 290338001374 HemK family putative methylases; Region: hemK_fam; TIGR00536 290338001375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338001376 S-adenosylmethionine binding site [chemical binding]; other site 290338001377 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 290338001378 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290338001379 Tetramer interface [polypeptide binding]; other site 290338001380 active site 290338001381 FMN-binding site [chemical binding]; other site 290338001382 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 290338001383 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 290338001384 hypothetical protein; Provisional; Region: PRK10621 290338001385 Predicted permeases [General function prediction only]; Region: COG0730 290338001386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 290338001387 YfcL protein; Region: YfcL; pfam08891 290338001388 Uncharacterized conserved protein [Function unknown]; Region: COG4121 290338001389 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 290338001390 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 290338001391 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290338001392 dimer interface [polypeptide binding]; other site 290338001393 active site 290338001394 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 290338001395 putative transporter; Provisional; Region: PRK12382 290338001396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338001397 putative substrate translocation pore; other site 290338001398 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 290338001399 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 290338001400 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 290338001401 ligand binding site [chemical binding]; other site 290338001402 NAD binding site [chemical binding]; other site 290338001403 catalytic site [active] 290338001404 homodimer interface [polypeptide binding]; other site 290338001405 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 290338001406 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290338001407 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290338001408 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 290338001409 dimerization interface 3.5A [polypeptide binding]; other site 290338001410 active site 290338001411 hypothetical protein; Provisional; Region: PRK10847 290338001412 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290338001413 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 290338001414 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290338001415 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 290338001416 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290338001417 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290338001418 cell division protein DedD; Provisional; Region: PRK11633 290338001419 Sporulation related domain; Region: SPOR; pfam05036 290338001420 colicin V production protein; Provisional; Region: PRK10845 290338001421 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 290338001422 amidophosphoribosyltransferase; Provisional; Region: PRK09246 290338001423 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290338001424 active site 290338001425 tetramer interface [polypeptide binding]; other site 290338001426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338001427 active site 290338001428 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 290338001429 Flavoprotein; Region: Flavoprotein; pfam02441 290338001430 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 290338001431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338001432 substrate binding pocket [chemical binding]; other site 290338001433 membrane-bound complex binding site; other site 290338001434 hinge residues; other site 290338001435 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 290338001436 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338001437 substrate binding pocket [chemical binding]; other site 290338001438 membrane-bound complex binding site; other site 290338001439 hinge residues; other site 290338001440 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338001441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338001442 dimer interface [polypeptide binding]; other site 290338001443 conserved gate region; other site 290338001444 putative PBP binding loops; other site 290338001445 ABC-ATPase subunit interface; other site 290338001446 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338001447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338001448 dimer interface [polypeptide binding]; other site 290338001449 conserved gate region; other site 290338001450 putative PBP binding loops; other site 290338001451 ABC-ATPase subunit interface; other site 290338001452 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 290338001453 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290338001454 Walker A/P-loop; other site 290338001455 ATP binding site [chemical binding]; other site 290338001456 Q-loop/lid; other site 290338001457 ABC transporter signature motif; other site 290338001458 Walker B; other site 290338001459 D-loop; other site 290338001460 H-loop/switch region; other site 290338001461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290338001462 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290338001463 Coenzyme A binding pocket [chemical binding]; other site 290338001464 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 290338001465 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 290338001466 putative NAD(P) binding site [chemical binding]; other site 290338001467 putative active site [active] 290338001468 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 290338001469 homooctamer interface [polypeptide binding]; other site 290338001470 active site 290338001471 glutathione S-transferase; Provisional; Region: PRK15113 290338001472 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290338001473 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 290338001474 N-terminal domain interface [polypeptide binding]; other site 290338001475 putative dimer interface [polypeptide binding]; other site 290338001476 putative substrate binding pocket (H-site) [chemical binding]; other site 290338001477 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290338001478 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 290338001479 active site 290338001480 metal binding site [ion binding]; metal-binding site 290338001481 homotetramer interface [polypeptide binding]; other site 290338001482 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 290338001483 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 290338001484 nudix motif; other site 290338001485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338001486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338001487 DNA binding site [nucleotide binding] 290338001488 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 290338001489 putative dimerization interface [polypeptide binding]; other site 290338001490 putative ligand binding site [chemical binding]; other site 290338001491 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338001492 active site 290338001493 phosphorylation site [posttranslational modification] 290338001494 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 290338001495 active site 290338001496 P-loop; other site 290338001497 phosphorylation site [posttranslational modification] 290338001498 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 290338001499 transketolase; Reviewed; Region: PRK05899 290338001500 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290338001501 TPP-binding site [chemical binding]; other site 290338001502 dimer interface [polypeptide binding]; other site 290338001503 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290338001504 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290338001505 PYR/PP interface [polypeptide binding]; other site 290338001506 dimer interface [polypeptide binding]; other site 290338001507 TPP binding site [chemical binding]; other site 290338001508 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290338001509 hypothetical protein; Provisional; Region: PRK11588 290338001510 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290338001511 phosphate acetyltransferase; Reviewed; Region: PRK05632 290338001512 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338001513 DRTGG domain; Region: DRTGG; pfam07085 290338001514 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 290338001515 propionate/acetate kinase; Provisional; Region: PRK12379 290338001516 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 290338001517 hypothetical protein; Provisional; Region: PRK01816 290338001518 hypothetical protein; Validated; Region: PRK05445 290338001519 putative phosphatase; Provisional; Region: PRK11587 290338001520 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290338001521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338001522 motif II; other site 290338001523 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 290338001524 transmembrane helices; other site 290338001525 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338001526 TrkA-C domain; Region: TrkA_C; pfam02080 290338001527 TrkA-C domain; Region: TrkA_C; pfam02080 290338001528 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290338001529 5'-nucleotidase; Provisional; Region: PRK03826 290338001530 aminotransferase AlaT; Validated; Region: PRK09265 290338001531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338001532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338001533 homodimer interface [polypeptide binding]; other site 290338001534 catalytic residue [active] 290338001535 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 290338001536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338001537 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 290338001538 putative dimerization interface [polypeptide binding]; other site 290338001539 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 290338001540 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 290338001541 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 290338001542 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 290338001543 NADH dehydrogenase subunit D; Validated; Region: PRK06075 290338001544 NADH dehydrogenase subunit E; Validated; Region: PRK07539 290338001545 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 290338001546 putative dimer interface [polypeptide binding]; other site 290338001547 [2Fe-2S] cluster binding site [ion binding]; other site 290338001548 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 290338001549 SLBB domain; Region: SLBB; pfam10531 290338001550 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 290338001551 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 290338001552 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290338001553 catalytic loop [active] 290338001554 iron binding site [ion binding]; other site 290338001555 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 290338001556 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 290338001557 [4Fe-4S] binding site [ion binding]; other site 290338001558 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 290338001559 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 290338001560 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 290338001561 4Fe-4S binding domain; Region: Fer4; pfam00037 290338001562 4Fe-4S binding domain; Region: Fer4; pfam00037 290338001563 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 290338001564 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 290338001565 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 290338001566 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 290338001567 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290338001568 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 290338001569 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290338001570 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 290338001571 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290338001572 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 290338001573 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290338001574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338001575 active site 290338001576 phosphorylation site [posttranslational modification] 290338001577 intermolecular recognition site; other site 290338001578 dimerization interface [polypeptide binding]; other site 290338001579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290338001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338001581 Coenzyme A binding pocket [chemical binding]; other site 290338001582 hypothetical protein; Provisional; Region: PRK10404 290338001583 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 290338001584 isochorismate synthases; Region: isochor_syn; TIGR00543 290338001585 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290338001586 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290338001587 dimer interface [polypeptide binding]; other site 290338001588 tetramer interface [polypeptide binding]; other site 290338001589 PYR/PP interface [polypeptide binding]; other site 290338001590 TPP binding site [chemical binding]; other site 290338001591 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290338001592 TPP-binding site; other site 290338001593 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 290338001594 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290338001595 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290338001596 substrate binding site [chemical binding]; other site 290338001597 oxyanion hole (OAH) forming residues; other site 290338001598 trimer interface [polypeptide binding]; other site 290338001599 O-succinylbenzoate synthase; Provisional; Region: PRK05105 290338001600 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290338001601 active site 290338001602 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 290338001603 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 290338001604 acyl-activating enzyme (AAE) consensus motif; other site 290338001605 putative AMP binding site [chemical binding]; other site 290338001606 putative active site [active] 290338001607 putative CoA binding site [chemical binding]; other site 290338001608 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 290338001609 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 290338001610 tetramer interface [polypeptide binding]; other site 290338001611 heme binding pocket [chemical binding]; other site 290338001612 NADPH binding site [chemical binding]; other site 290338001613 YfaZ precursor; Region: YfaZ; pfam07437 290338001614 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 290338001615 hypothetical protein; Provisional; Region: PRK03673 290338001616 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 290338001617 putative MPT binding site; other site 290338001618 Competence-damaged protein; Region: CinA; cl00666 290338001619 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 290338001620 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338001621 Cysteine-rich domain; Region: CCG; pfam02754 290338001622 Cysteine-rich domain; Region: CCG; pfam02754 290338001623 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 290338001624 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 290338001625 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 290338001626 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290338001627 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290338001628 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 290338001629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338001630 putative substrate translocation pore; other site 290338001631 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 290338001632 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 290338001633 active site 290338001634 catalytic site [active] 290338001635 metal binding site [ion binding]; metal-binding site 290338001636 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290338001637 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290338001638 catalytic loop [active] 290338001639 iron binding site [ion binding]; other site 290338001640 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290338001641 dimer interface [polypeptide binding]; other site 290338001642 putative radical transfer pathway; other site 290338001643 diiron center [ion binding]; other site 290338001644 tyrosyl radical; other site 290338001645 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 290338001646 ATP cone domain; Region: ATP-cone; pfam03477 290338001647 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290338001648 active site 290338001649 dimer interface [polypeptide binding]; other site 290338001650 catalytic residues [active] 290338001651 effector binding site; other site 290338001652 R2 peptide binding site; other site 290338001653 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 290338001654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338001655 S-adenosylmethionine binding site [chemical binding]; other site 290338001656 DNA gyrase subunit A; Validated; Region: PRK05560 290338001657 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290338001658 CAP-like domain; other site 290338001659 active site 290338001660 primary dimer interface [polypeptide binding]; other site 290338001661 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338001662 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338001663 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338001664 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338001665 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338001666 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338001667 putative acyltransferase; Provisional; Region: PRK05790 290338001668 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290338001669 dimer interface [polypeptide binding]; other site 290338001670 active site 290338001671 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 290338001672 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290338001673 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 290338001674 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 290338001675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338001676 active site 290338001677 phosphorylation site [posttranslational modification] 290338001678 intermolecular recognition site; other site 290338001679 dimerization interface [polypeptide binding]; other site 290338001680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338001681 Walker A motif; other site 290338001682 ATP binding site [chemical binding]; other site 290338001683 Walker B motif; other site 290338001684 arginine finger; other site 290338001685 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338001686 sensory histidine kinase AtoS; Provisional; Region: PRK11360 290338001687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338001688 putative active site [active] 290338001689 heme pocket [chemical binding]; other site 290338001690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338001691 dimer interface [polypeptide binding]; other site 290338001692 phosphorylation site [posttranslational modification] 290338001693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338001694 ATP binding site [chemical binding]; other site 290338001695 Mg2+ binding site [ion binding]; other site 290338001696 G-X-G motif; other site 290338001697 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 290338001698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338001699 dimer interface [polypeptide binding]; other site 290338001700 phosphorylation site [posttranslational modification] 290338001701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338001702 ATP binding site [chemical binding]; other site 290338001703 Mg2+ binding site [ion binding]; other site 290338001704 G-X-G motif; other site 290338001705 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 290338001706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338001707 active site 290338001708 phosphorylation site [posttranslational modification] 290338001709 intermolecular recognition site; other site 290338001710 dimerization interface [polypeptide binding]; other site 290338001711 transcriptional regulator RcsB; Provisional; Region: PRK10840 290338001712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338001713 active site 290338001714 phosphorylation site [posttranslational modification] 290338001715 intermolecular recognition site; other site 290338001716 dimerization interface [polypeptide binding]; other site 290338001717 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338001718 DNA binding residues [nucleotide binding] 290338001719 dimerization interface [polypeptide binding]; other site 290338001720 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 290338001721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338001722 ATP binding site [chemical binding]; other site 290338001723 G-X-G motif; other site 290338001724 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290338001725 putative binding surface; other site 290338001726 active site 290338001727 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338001728 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338001729 trimer interface [polypeptide binding]; other site 290338001730 eyelet of channel; other site 290338001731 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 290338001732 ApbE family; Region: ApbE; pfam02424 290338001733 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 290338001734 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 290338001735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338001736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338001737 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 290338001738 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290338001739 DNA binding site [nucleotide binding] 290338001740 active site 290338001741 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 290338001742 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 290338001743 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 290338001744 Walker A/P-loop; other site 290338001745 ATP binding site [chemical binding]; other site 290338001746 Q-loop/lid; other site 290338001747 ABC transporter signature motif; other site 290338001748 Walker B; other site 290338001749 D-loop; other site 290338001750 H-loop/switch region; other site 290338001751 MgtE intracellular N domain; Region: MgtE_N; cl15244 290338001752 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 290338001753 MgtE intracellular N domain; Region: MgtE_N; smart00924 290338001754 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290338001755 Divalent cation transporter; Region: MgtE; cl00786 290338001756 malate:quinone oxidoreductase; Validated; Region: PRK05257 290338001757 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 290338001758 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 290338001759 secondary substrate binding site; other site 290338001760 primary substrate binding site; other site 290338001761 inhibition loop; other site 290338001762 dimerization interface [polypeptide binding]; other site 290338001763 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 290338001764 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 290338001765 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290338001766 [4Fe-4S] binding site [ion binding]; other site 290338001767 molybdopterin cofactor binding site; other site 290338001768 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 290338001769 molybdopterin cofactor binding site; other site 290338001770 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 290338001771 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 290338001772 4Fe-4S binding domain; Region: Fer4_5; pfam12801 290338001773 4Fe-4S binding domain; Region: Fer4; cl02805 290338001774 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 290338001775 cytochrome c-type protein NapC; Provisional; Region: PRK10617 290338001776 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 290338001777 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 290338001778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338001779 Walker A/P-loop; other site 290338001780 ATP binding site [chemical binding]; other site 290338001781 Q-loop/lid; other site 290338001782 ABC transporter signature motif; other site 290338001783 Walker B; other site 290338001784 D-loop; other site 290338001785 H-loop/switch region; other site 290338001786 heme exporter protein CcmB; Region: ccmB; TIGR01190 290338001787 heme exporter protein CcmC; Region: ccmC; TIGR01191 290338001788 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 290338001789 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 290338001790 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 290338001791 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 290338001792 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290338001793 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 290338001794 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 290338001795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338001796 binding surface 290338001797 TPR motif; other site 290338001798 transcriptional regulator NarP; Provisional; Region: PRK10403 290338001799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338001800 active site 290338001801 phosphorylation site [posttranslational modification] 290338001802 intermolecular recognition site; other site 290338001803 dimerization interface [polypeptide binding]; other site 290338001804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338001805 DNA binding residues [nucleotide binding] 290338001806 dimerization interface [polypeptide binding]; other site 290338001807 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 290338001808 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 290338001809 Sulfatase; Region: Sulfatase; cl17466 290338001810 hypothetical protein; Provisional; Region: PRK13689 290338001811 Nucleoid-associated protein [General function prediction only]; Region: COG3081 290338001812 nucleoid-associated protein NdpA; Validated; Region: PRK00378 290338001813 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290338001814 5S rRNA interface [nucleotide binding]; other site 290338001815 CTC domain interface [polypeptide binding]; other site 290338001816 L16 interface [polypeptide binding]; other site 290338001817 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290338001818 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338001819 ATP binding site [chemical binding]; other site 290338001820 putative Mg++ binding site [ion binding]; other site 290338001821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338001822 nucleotide binding region [chemical binding]; other site 290338001823 ATP-binding site [chemical binding]; other site 290338001824 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 290338001825 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 290338001826 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338001827 RNA binding surface [nucleotide binding]; other site 290338001828 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 290338001829 active site 290338001830 uracil binding [chemical binding]; other site 290338001831 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 290338001832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338001833 putative substrate translocation pore; other site 290338001834 hypothetical protein; Provisional; Region: PRK11835 290338001835 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 290338001836 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338001837 Walker A/P-loop; other site 290338001838 ATP binding site [chemical binding]; other site 290338001839 Q-loop/lid; other site 290338001840 ABC transporter signature motif; other site 290338001841 Walker B; other site 290338001842 D-loop; other site 290338001843 H-loop/switch region; other site 290338001844 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338001845 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338001846 Walker A/P-loop; other site 290338001847 ATP binding site [chemical binding]; other site 290338001848 Q-loop/lid; other site 290338001849 ABC transporter signature motif; other site 290338001850 Walker B; other site 290338001851 D-loop; other site 290338001852 H-loop/switch region; other site 290338001853 microcin C ABC transporter permease; Provisional; Region: PRK15021 290338001854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338001855 dimer interface [polypeptide binding]; other site 290338001856 conserved gate region; other site 290338001857 ABC-ATPase subunit interface; other site 290338001858 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 290338001859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338001860 dimer interface [polypeptide binding]; other site 290338001861 conserved gate region; other site 290338001862 putative PBP binding loops; other site 290338001863 ABC-ATPase subunit interface; other site 290338001864 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 290338001865 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 290338001866 phage resistance protein; Provisional; Region: PRK10551 290338001867 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290338001868 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338001869 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 290338001870 NlpC/P60 family; Region: NLPC_P60; pfam00877 290338001871 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290338001872 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 290338001873 active site 290338001874 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 290338001875 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 290338001876 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 290338001877 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290338001878 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290338001879 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290338001880 mannonate dehydratase; Provisional; Region: PRK03906 290338001881 mannonate dehydratase; Region: uxuA; TIGR00695 290338001882 elongation factor P; Provisional; Region: PRK04542 290338001883 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290338001884 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290338001885 RNA binding site [nucleotide binding]; other site 290338001886 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290338001887 RNA binding site [nucleotide binding]; other site 290338001888 sugar efflux transporter B; Provisional; Region: PRK15011 290338001889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338001890 putative substrate translocation pore; other site 290338001891 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 290338001892 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338001893 active site 290338001894 phosphorylation site [posttranslational modification] 290338001895 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290338001896 dimerization domain swap beta strand [polypeptide binding]; other site 290338001897 regulatory protein interface [polypeptide binding]; other site 290338001898 active site 290338001899 regulatory phosphorylation site [posttranslational modification]; other site 290338001900 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290338001901 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290338001902 putative substrate binding site [chemical binding]; other site 290338001903 putative ATP binding site [chemical binding]; other site 290338001904 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 290338001905 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 290338001906 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290338001907 active site 290338001908 P-loop; other site 290338001909 phosphorylation site [posttranslational modification] 290338001910 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 290338001911 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 290338001912 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338001913 substrate binding site [chemical binding]; other site 290338001914 ATP binding site [chemical binding]; other site 290338001915 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 290338001916 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 290338001917 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 290338001918 Nucleoside recognition; Region: Gate; pfam07670 290338001919 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 290338001920 putative kinase; Provisional; Region: PRK09954 290338001921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290338001922 putative DNA binding site [nucleotide binding]; other site 290338001923 putative Zn2+ binding site [ion binding]; other site 290338001924 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 290338001925 substrate binding site [chemical binding]; other site 290338001926 ATP binding site [chemical binding]; other site 290338001927 endonuclease IV; Provisional; Region: PRK01060 290338001928 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 290338001929 AP (apurinic/apyrimidinic) site pocket; other site 290338001930 DNA interaction; other site 290338001931 Metal-binding active site; metal-binding site 290338001932 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 290338001933 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 290338001934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338001935 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 290338001936 putative dimerization interface [polypeptide binding]; other site 290338001937 lysine transporter; Provisional; Region: PRK10836 290338001938 putative outer membrane receptor; Provisional; Region: PRK13513 290338001939 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338001940 N-terminal plug; other site 290338001941 ligand-binding site [chemical binding]; other site 290338001942 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 290338001943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338001944 putative substrate translocation pore; other site 290338001945 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290338001946 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290338001947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338001948 motif II; other site 290338001949 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290338001950 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290338001951 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290338001952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338001953 non-specific DNA binding site [nucleotide binding]; other site 290338001954 salt bridge; other site 290338001955 sequence-specific DNA binding site [nucleotide binding]; other site 290338001956 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 290338001957 S-formylglutathione hydrolase; Region: PLN02442 290338001958 GTP cyclohydrolase I; Provisional; Region: PLN03044 290338001959 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290338001960 active site 290338001961 Predicted membrane protein [Function unknown]; Region: COG2311 290338001962 hypothetical protein; Provisional; Region: PRK10835 290338001963 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 290338001964 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338001965 DNA binding site [nucleotide binding] 290338001966 domain linker motif; other site 290338001967 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290338001968 dimerization interface (closed form) [polypeptide binding]; other site 290338001969 ligand binding site [chemical binding]; other site 290338001970 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 290338001971 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 290338001972 ligand binding site [chemical binding]; other site 290338001973 calcium binding site [ion binding]; other site 290338001974 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 290338001975 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338001976 Walker A/P-loop; other site 290338001977 ATP binding site [chemical binding]; other site 290338001978 Q-loop/lid; other site 290338001979 ABC transporter signature motif; other site 290338001980 Walker B; other site 290338001981 D-loop; other site 290338001982 H-loop/switch region; other site 290338001983 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338001984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338001985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338001986 TM-ABC transporter signature motif; other site 290338001987 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 290338001988 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290338001989 putative active site [active] 290338001990 cytidine deaminase; Provisional; Region: PRK09027 290338001991 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290338001992 active site 290338001993 catalytic motif [active] 290338001994 Zn binding site [ion binding]; other site 290338001995 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290338001996 active site 290338001997 catalytic motif [active] 290338001998 Zn binding site [ion binding]; other site 290338001999 hypothetical protein; Provisional; Region: PRK10711 290338002000 hypothetical protein; Provisional; Region: PRK01821 290338002001 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 290338002002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338002003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338002004 dimerization interface [polypeptide binding]; other site 290338002005 benzoate transport; Region: 2A0115; TIGR00895 290338002006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338002007 putative substrate translocation pore; other site 290338002008 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 290338002009 Cupin domain; Region: Cupin_2; pfam07883 290338002010 Cupin domain; Region: Cupin_2; pfam07883 290338002011 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290338002012 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290338002013 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 290338002014 maleylacetoacetate isomerase; Region: maiA; TIGR01262 290338002015 C-terminal domain interface [polypeptide binding]; other site 290338002016 GSH binding site (G-site) [chemical binding]; other site 290338002017 putative dimer interface [polypeptide binding]; other site 290338002018 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 290338002019 dimer interface [polypeptide binding]; other site 290338002020 N-terminal domain interface [polypeptide binding]; other site 290338002021 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 290338002022 salicylate hydroxylase; Provisional; Region: PRK08163 290338002023 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290338002024 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 290338002025 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290338002026 FMN binding site [chemical binding]; other site 290338002027 active site 290338002028 catalytic residues [active] 290338002029 substrate binding site [chemical binding]; other site 290338002030 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 290338002031 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 290338002032 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290338002033 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290338002034 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 290338002035 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 290338002036 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 290338002037 D-lactate dehydrogenase; Provisional; Region: PRK11183 290338002038 FAD binding domain; Region: FAD_binding_4; pfam01565 290338002039 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 290338002040 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 290338002041 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290338002042 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290338002043 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290338002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338002045 dimer interface [polypeptide binding]; other site 290338002046 conserved gate region; other site 290338002047 ABC-ATPase subunit interface; other site 290338002048 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290338002049 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290338002050 Walker A/P-loop; other site 290338002051 ATP binding site [chemical binding]; other site 290338002052 Q-loop/lid; other site 290338002053 ABC transporter signature motif; other site 290338002054 Walker B; other site 290338002055 D-loop; other site 290338002056 H-loop/switch region; other site 290338002057 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 290338002058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338002059 putative PBP binding loops; other site 290338002060 ABC-ATPase subunit interface; other site 290338002061 transcriptional regulator MirA; Provisional; Region: PRK15043 290338002062 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 290338002063 DNA binding residues [nucleotide binding] 290338002064 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 290338002065 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 290338002066 GAF domain; Region: GAF; pfam01590 290338002067 Histidine kinase; Region: His_kinase; pfam06580 290338002068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338002069 ATP binding site [chemical binding]; other site 290338002070 Mg2+ binding site [ion binding]; other site 290338002071 G-X-G motif; other site 290338002072 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 290338002073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338002074 active site 290338002075 phosphorylation site [posttranslational modification] 290338002076 intermolecular recognition site; other site 290338002077 dimerization interface [polypeptide binding]; other site 290338002078 LytTr DNA-binding domain; Region: LytTR; pfam04397 290338002079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 290338002080 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 290338002081 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 290338002082 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 290338002083 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290338002084 active site 290338002085 HIGH motif; other site 290338002086 KMSKS motif; other site 290338002087 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290338002088 tRNA binding surface [nucleotide binding]; other site 290338002089 anticodon binding site; other site 290338002090 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 290338002091 dimer interface [polypeptide binding]; other site 290338002092 putative tRNA-binding site [nucleotide binding]; other site 290338002093 antiporter inner membrane protein; Provisional; Region: PRK11670 290338002094 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290338002095 Walker A motif; other site 290338002096 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 290338002097 fimbrial chaperone protein; Provisional; Region: PRK15220 290338002098 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 290338002099 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338002100 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 290338002101 PapC N-terminal domain; Region: PapC_N; pfam13954 290338002102 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338002103 PapC C-terminal domain; Region: PapC_C; pfam13953 290338002104 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 290338002105 Predicted integral membrane protein [Function unknown]; Region: COG5455 290338002106 TPP riboswitch (THI element) 290338002107 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 290338002108 substrate binding site [chemical binding]; other site 290338002109 multimerization interface [polypeptide binding]; other site 290338002110 ATP binding site [chemical binding]; other site 290338002111 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290338002112 dimer interface [polypeptide binding]; other site 290338002113 substrate binding site [chemical binding]; other site 290338002114 ATP binding site [chemical binding]; other site 290338002115 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290338002116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338002117 DNA-binding site [nucleotide binding]; DNA binding site 290338002118 UTRA domain; Region: UTRA; pfam07702 290338002119 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338002120 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290338002121 substrate binding site [chemical binding]; other site 290338002122 ATP binding site [chemical binding]; other site 290338002123 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 290338002124 nucleoside transporter; Region: 2A0110; TIGR00889 290338002125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338002126 putative substrate translocation pore; other site 290338002127 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 290338002128 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 290338002129 putative active site; other site 290338002130 catalytic residue [active] 290338002131 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 290338002132 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 290338002133 N- and C-terminal domain interface [polypeptide binding]; other site 290338002134 active site 290338002135 MgATP binding site [chemical binding]; other site 290338002136 catalytic site [active] 290338002137 metal binding site [ion binding]; metal-binding site 290338002138 carbohydrate binding site [chemical binding]; other site 290338002139 putative homodimer interface [polypeptide binding]; other site 290338002140 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290338002141 classical (c) SDRs; Region: SDR_c; cd05233 290338002142 NAD(P) binding site [chemical binding]; other site 290338002143 active site 290338002144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338002145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338002146 DNA binding site [nucleotide binding] 290338002147 domain linker motif; other site 290338002148 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 290338002149 dimerization interface [polypeptide binding]; other site 290338002150 ligand binding site [chemical binding]; other site 290338002151 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 290338002152 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 290338002153 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 290338002154 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290338002155 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290338002156 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290338002157 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 290338002158 N- and C-terminal domain interface [polypeptide binding]; other site 290338002159 D-xylulose kinase; Region: XylB; TIGR01312 290338002160 active site 290338002161 MgATP binding site [chemical binding]; other site 290338002162 catalytic site [active] 290338002163 metal binding site [ion binding]; metal-binding site 290338002164 xylulose binding site [chemical binding]; other site 290338002165 homodimer interface [polypeptide binding]; other site 290338002166 polyol permease family; Region: 2A0118; TIGR00897 290338002167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338002168 putative substrate translocation pore; other site 290338002169 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 290338002170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338002171 active site 290338002172 motif I; other site 290338002173 motif II; other site 290338002174 lipid kinase; Reviewed; Region: PRK13054 290338002175 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290338002176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338002177 salt bridge; other site 290338002178 non-specific DNA binding site [nucleotide binding]; other site 290338002179 sequence-specific DNA binding site [nucleotide binding]; other site 290338002180 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 290338002181 putative protease; Provisional; Region: PRK15452 290338002182 Peptidase family U32; Region: Peptidase_U32; pfam01136 290338002183 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 290338002184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338002185 active site 290338002186 phosphorylation site [posttranslational modification] 290338002187 intermolecular recognition site; other site 290338002188 dimerization interface [polypeptide binding]; other site 290338002189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338002190 DNA binding site [nucleotide binding] 290338002191 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 290338002192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338002193 dimerization interface [polypeptide binding]; other site 290338002194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338002195 dimer interface [polypeptide binding]; other site 290338002196 phosphorylation site [posttranslational modification] 290338002197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338002198 ATP binding site [chemical binding]; other site 290338002199 Mg2+ binding site [ion binding]; other site 290338002200 G-X-G motif; other site 290338002201 putative transporter; Provisional; Region: PRK10504 290338002202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338002203 putative substrate translocation pore; other site 290338002204 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 290338002205 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 290338002206 Protein export membrane protein; Region: SecD_SecF; cl14618 290338002207 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 290338002208 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338002209 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338002210 putative chaperone; Provisional; Region: PRK11678 290338002211 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 290338002212 nucleotide binding site [chemical binding]; other site 290338002213 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290338002214 SBD interface [polypeptide binding]; other site 290338002215 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 290338002216 AlkA N-terminal domain; Region: AlkA_N; smart01009 290338002217 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290338002218 minor groove reading motif; other site 290338002219 helix-hairpin-helix signature motif; other site 290338002220 substrate binding pocket [chemical binding]; other site 290338002221 active site 290338002222 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 290338002223 putative diguanylate cyclase; Provisional; Region: PRK09776 290338002224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338002225 putative active site [active] 290338002226 heme pocket [chemical binding]; other site 290338002227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338002228 putative active site [active] 290338002229 heme pocket [chemical binding]; other site 290338002230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338002231 putative active site [active] 290338002232 heme pocket [chemical binding]; other site 290338002233 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338002234 metal binding site [ion binding]; metal-binding site 290338002235 active site 290338002236 I-site; other site 290338002237 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338002238 uridine/cytidine kinase; Provisional; Region: PRK05480 290338002239 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 290338002240 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290338002241 trimer interface [polypeptide binding]; other site 290338002242 active site 290338002243 putative assembly protein; Provisional; Region: PRK10833 290338002244 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290338002245 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290338002246 FOG: CBS domain [General function prediction only]; Region: COG0517 290338002247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290338002248 Transporter associated domain; Region: CorC_HlyC; smart01091 290338002249 polysaccharide export protein Wza; Provisional; Region: PRK15078 290338002250 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 290338002251 SLBB domain; Region: SLBB; pfam10531 290338002252 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290338002253 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290338002254 active site 290338002255 tyrosine kinase; Provisional; Region: PRK11519 290338002256 Chain length determinant protein; Region: Wzz; pfam02706 290338002257 Chain length determinant protein; Region: Wzz; cl15801 290338002258 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 290338002259 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338002260 putative glycosyl transferase; Provisional; Region: PRK10018 290338002261 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 290338002262 active site 290338002263 putative acyl transferase; Provisional; Region: PRK10191 290338002264 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290338002265 trimer interface [polypeptide binding]; other site 290338002266 active site 290338002267 substrate binding site [chemical binding]; other site 290338002268 CoA binding site [chemical binding]; other site 290338002269 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 290338002270 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290338002271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290338002272 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 290338002273 putative glycosyl transferase; Provisional; Region: PRK10063 290338002274 colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009 290338002275 active site 290338002276 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 290338002277 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 290338002278 putative trimer interface [polypeptide binding]; other site 290338002279 putative active site [active] 290338002280 putative substrate binding site [chemical binding]; other site 290338002281 putative CoA binding site [chemical binding]; other site 290338002282 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 290338002283 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 290338002284 NADP-binding site; other site 290338002285 homotetramer interface [polypeptide binding]; other site 290338002286 substrate binding site [chemical binding]; other site 290338002287 homodimer interface [polypeptide binding]; other site 290338002288 active site 290338002289 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 290338002290 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 290338002291 NADP binding site [chemical binding]; other site 290338002292 active site 290338002293 putative substrate binding site [chemical binding]; other site 290338002294 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 290338002295 active site 290338002296 GDP-Mannose binding site [chemical binding]; other site 290338002297 dimer interface [polypeptide binding]; other site 290338002298 modified nudix motif 290338002299 metal binding site [ion binding]; metal-binding site 290338002300 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 290338002301 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 290338002302 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 290338002303 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 290338002304 Substrate binding site; other site 290338002305 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 290338002306 phosphomannomutase CpsG; Provisional; Region: PRK15414 290338002307 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 290338002308 active site 290338002309 substrate binding site [chemical binding]; other site 290338002310 metal binding site [ion binding]; metal-binding site 290338002311 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 290338002312 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 290338002313 colanic acid exporter; Provisional; Region: PRK10459 290338002314 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 290338002315 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 290338002316 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 290338002317 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 290338002318 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290338002319 putative ADP-binding pocket [chemical binding]; other site 290338002320 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 290338002321 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 290338002322 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290338002323 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290338002324 active site 290338002325 tetramer interface; other site 290338002326 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 290338002327 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290338002328 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290338002329 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 290338002330 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 290338002331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290338002332 UDP-galactopyranose mutase; Region: GLF; pfam03275 290338002333 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 290338002334 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 290338002335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290338002336 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 290338002337 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 290338002338 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 290338002339 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290338002340 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290338002341 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290338002342 chain length determinant protein WzzB; Provisional; Region: PRK15471 290338002343 Chain length determinant protein; Region: Wzz; pfam02706 290338002344 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 290338002345 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 290338002346 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 290338002347 metal binding site [ion binding]; metal-binding site 290338002348 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290338002349 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290338002350 substrate binding site [chemical binding]; other site 290338002351 glutamase interaction surface [polypeptide binding]; other site 290338002352 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290338002353 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 290338002354 catalytic residues [active] 290338002355 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 290338002356 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290338002357 putative active site [active] 290338002358 oxyanion strand; other site 290338002359 catalytic triad [active] 290338002360 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 290338002361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338002362 active site 290338002363 motif I; other site 290338002364 motif II; other site 290338002365 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290338002366 putative active site pocket [active] 290338002367 4-fold oligomerization interface [polypeptide binding]; other site 290338002368 metal binding residues [ion binding]; metal-binding site 290338002369 3-fold/trimer interface [polypeptide binding]; other site 290338002370 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 290338002371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338002372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338002373 homodimer interface [polypeptide binding]; other site 290338002374 catalytic residue [active] 290338002375 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 290338002376 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290338002377 NAD binding site [chemical binding]; other site 290338002378 dimerization interface [polypeptide binding]; other site 290338002379 product binding site; other site 290338002380 substrate binding site [chemical binding]; other site 290338002381 zinc binding site [ion binding]; other site 290338002382 catalytic residues [active] 290338002383 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290338002384 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 290338002385 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 290338002386 histidine operon leader 290338002387 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290338002388 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290338002389 putative NAD(P) binding site [chemical binding]; other site 290338002390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338002391 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 290338002392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338002393 dimerization interface [polypeptide binding]; other site 290338002394 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290338002395 exonuclease I; Provisional; Region: sbcB; PRK11779 290338002396 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 290338002397 active site 290338002398 catalytic site [active] 290338002399 substrate binding site [chemical binding]; other site 290338002400 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 290338002401 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 290338002402 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 290338002403 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 290338002404 DNA gyrase inhibitor; Provisional; Region: PRK10016 290338002405 Predicted membrane protein [Function unknown]; Region: COG1289 290338002406 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290338002407 hypothetical protein; Provisional; Region: PRK05423 290338002408 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 290338002409 propionate kinase; Reviewed; Region: PRK12397 290338002410 propionate/acetate kinase; Provisional; Region: PRK12379 290338002411 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290338002412 G1 box; other site 290338002413 GTP/Mg2+ binding site [chemical binding]; other site 290338002414 G2 box; other site 290338002415 G3 box; other site 290338002416 Switch II region; other site 290338002417 G4 box; other site 290338002418 G5 box; other site 290338002419 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 290338002420 putative hexamer interface [polypeptide binding]; other site 290338002421 putative hexagonal pore; other site 290338002422 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 290338002423 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 290338002424 putative hexamer interface [polypeptide binding]; other site 290338002425 putative hexagonal pore; other site 290338002426 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 290338002427 putative hexamer interface [polypeptide binding]; other site 290338002428 putative hexagonal pore; other site 290338002429 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 290338002430 SLBB domain; Region: SLBB; pfam10531 290338002431 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 290338002432 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 290338002433 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 290338002434 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 290338002435 putative active site [active] 290338002436 metal binding site [ion binding]; metal-binding site 290338002437 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 290338002438 putative catalytic cysteine [active] 290338002439 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 290338002440 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 290338002441 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cl01889 290338002442 Hexamer/Pentamer interface [polypeptide binding]; other site 290338002443 central pore; other site 290338002444 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 290338002445 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 290338002446 Propanediol utilisation protein PduL; Region: PduL; pfam06130 290338002447 Propanediol utilisation protein PduL; Region: PduL; pfam06130 290338002448 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 290338002449 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 290338002450 Hexamer interface [polypeptide binding]; other site 290338002451 Hexagonal pore residue; other site 290338002452 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 290338002453 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 290338002454 Hexamer interface [polypeptide binding]; other site 290338002455 Putative hexagonal pore residue; other site 290338002456 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 290338002457 Cell division protein FtsA; Region: FtsA; cl17206 290338002458 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 290338002459 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 290338002460 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 290338002461 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 290338002462 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 290338002463 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 290338002464 alpha-beta subunit interface [polypeptide binding]; other site 290338002465 alpha-gamma subunit interface [polypeptide binding]; other site 290338002466 active site 290338002467 substrate and K+ binding site; other site 290338002468 K+ binding site [ion binding]; other site 290338002469 cobalamin binding site [chemical binding]; other site 290338002470 propanediol utilization protein PduB; Provisional; Region: PRK15415 290338002471 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 290338002472 putative hexamer interface [polypeptide binding]; other site 290338002473 putative hexagonal pore; other site 290338002474 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 290338002475 putative hexamer interface [polypeptide binding]; other site 290338002476 putative hexagonal pore; other site 290338002477 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 290338002478 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 290338002479 Hexamer interface [polypeptide binding]; other site 290338002480 Putative hexagonal pore residue; other site 290338002481 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290338002482 amphipathic channel; other site 290338002483 Asn-Pro-Ala signature motifs; other site 290338002484 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 290338002485 Sensory domain found in PocR; Region: PocR; pfam10114 290338002486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338002487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338002488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338002489 cobalamin riboswitch 290338002490 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 290338002491 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 290338002492 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 290338002493 catalytic triad [active] 290338002494 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 290338002495 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 290338002496 Precorrin-8X methylmutase; Region: CbiC; pfam02570 290338002497 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 290338002498 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 290338002499 active site 290338002500 putative homodimer interface [polypeptide binding]; other site 290338002501 SAM binding site [chemical binding]; other site 290338002502 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 290338002503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338002504 S-adenosylmethionine binding site [chemical binding]; other site 290338002505 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 290338002506 active site 290338002507 SAM binding site [chemical binding]; other site 290338002508 homodimer interface [polypeptide binding]; other site 290338002509 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 290338002510 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 290338002511 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 290338002512 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 290338002513 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 290338002514 active site 290338002515 SAM binding site [chemical binding]; other site 290338002516 homodimer interface [polypeptide binding]; other site 290338002517 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 290338002518 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 290338002519 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 290338002520 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 290338002521 active site 290338002522 C-terminal domain interface [polypeptide binding]; other site 290338002523 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 290338002524 active site 290338002525 N-terminal domain interface [polypeptide binding]; other site 290338002526 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 290338002527 active site 290338002528 SAM binding site [chemical binding]; other site 290338002529 homodimer interface [polypeptide binding]; other site 290338002530 cobalt transport protein CbiM; Validated; Region: PRK08319 290338002531 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 290338002532 cobalt transport protein CbiN; Provisional; Region: PRK02898 290338002533 cobalt transport protein CbiQ; Provisional; Region: PRK15485 290338002534 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 290338002535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290338002536 Walker A/P-loop; other site 290338002537 ATP binding site [chemical binding]; other site 290338002538 Q-loop/lid; other site 290338002539 ABC transporter signature motif; other site 290338002540 Walker B; other site 290338002541 D-loop; other site 290338002542 H-loop/switch region; other site 290338002543 cobyric acid synthase; Provisional; Region: PRK00784 290338002544 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338002545 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338002546 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 290338002547 catalytic triad [active] 290338002548 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 290338002549 homotrimer interface [polypeptide binding]; other site 290338002550 Walker A motif; other site 290338002551 GTP binding site [chemical binding]; other site 290338002552 Walker B motif; other site 290338002553 cobalamin synthase; Reviewed; Region: cobS; PRK00235 290338002554 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 290338002555 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 290338002556 putative dimer interface [polypeptide binding]; other site 290338002557 active site pocket [active] 290338002558 putative cataytic base [active] 290338002559 L,D-transpeptidase; Provisional; Region: PRK10190 290338002560 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338002561 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290338002562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338002563 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 290338002564 dimerization interface [polypeptide binding]; other site 290338002565 substrate binding pocket [chemical binding]; other site 290338002566 SnoaL-like domain; Region: SnoaL_4; pfam13577 290338002567 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 290338002568 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 290338002569 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 290338002570 NlpC/P60 family; Region: NLPC_P60; cl17555 290338002571 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 290338002572 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290338002573 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 290338002574 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290338002575 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338002576 ABC-ATPase subunit interface; other site 290338002577 dimer interface [polypeptide binding]; other site 290338002578 putative PBP binding regions; other site 290338002579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338002580 S-adenosylmethionine binding site [chemical binding]; other site 290338002581 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 290338002582 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290338002583 intersubunit interface [polypeptide binding]; other site 290338002584 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338002585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338002586 N-terminal plug; other site 290338002587 ligand-binding site [chemical binding]; other site 290338002588 MATE family multidrug exporter; Provisional; Region: PRK10189 290338002589 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 290338002590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 290338002591 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290338002592 DNA-binding site [nucleotide binding]; DNA binding site 290338002593 RNA-binding motif; other site 290338002594 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290338002595 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 290338002596 Walker A/P-loop; other site 290338002597 ATP binding site [chemical binding]; other site 290338002598 Q-loop/lid; other site 290338002599 ABC transporter signature motif; other site 290338002600 Walker B; other site 290338002601 D-loop; other site 290338002602 H-loop/switch region; other site 290338002603 Predicted transcriptional regulators [Transcription]; Region: COG1733 290338002604 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290338002605 SnoaL-like domain; Region: SnoaL_2; pfam12680 290338002606 short chain dehydrogenase; Provisional; Region: PRK06523 290338002607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338002608 NAD(P) binding site [chemical binding]; other site 290338002609 active site 290338002610 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290338002611 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290338002612 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 290338002613 active site 290338002614 AMP nucleosidase; Provisional; Region: PRK08292 290338002615 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 290338002616 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 290338002617 shikimate transporter; Provisional; Region: PRK09952 290338002618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338002619 putative substrate translocation pore; other site 290338002620 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290338002621 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338002622 Walker A/P-loop; other site 290338002623 ATP binding site [chemical binding]; other site 290338002624 Q-loop/lid; other site 290338002625 ABC transporter signature motif; other site 290338002626 Walker B; other site 290338002627 D-loop; other site 290338002628 H-loop/switch region; other site 290338002629 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 290338002630 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 290338002631 putative ligand binding residues [chemical binding]; other site 290338002632 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338002633 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338002634 ABC-ATPase subunit interface; other site 290338002635 dimer interface [polypeptide binding]; other site 290338002636 putative PBP binding regions; other site 290338002637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 290338002638 Integrase core domain; Region: rve; pfam00665 290338002639 Integrase core domain; Region: rve_3; pfam13683 290338002640 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290338002641 DNA-binding interface [nucleotide binding]; DNA binding site 290338002642 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 290338002643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338002644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338002645 DNA binding residues [nucleotide binding] 290338002646 dimerization interface [polypeptide binding]; other site 290338002647 Condensation domain; Region: Condensation; pfam00668 290338002648 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002649 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 290338002650 acyl-activating enzyme (AAE) consensus motif; other site 290338002651 AMP binding site [chemical binding]; other site 290338002652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002653 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338002654 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338002655 active site 290338002656 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338002657 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 290338002658 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 290338002659 KR domain; Region: KR; pfam08659 290338002660 putative NADP binding site [chemical binding]; other site 290338002661 active site 290338002662 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 290338002663 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 290338002664 Enoylreductase; Region: PKS_ER; smart00829 290338002665 NAD(P) binding site [chemical binding]; other site 290338002666 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002667 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338002668 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338002669 active site 290338002670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002671 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 290338002672 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290338002673 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290338002674 acyl carrier protein; Provisional; Region: PRK07081 290338002675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290338002676 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290338002677 active site 290338002678 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 290338002679 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338002680 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290338002681 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 290338002682 acyl-activating enzyme (AAE) consensus motif; other site 290338002683 AMP binding site [chemical binding]; other site 290338002684 Condensation domain; Region: Condensation; pfam00668 290338002685 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002686 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 290338002687 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290338002688 acyl-activating enzyme (AAE) consensus motif; other site 290338002689 AMP binding site [chemical binding]; other site 290338002690 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002691 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338002692 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338002693 active site 290338002694 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 290338002695 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338002696 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002697 Condensation domain; Region: Condensation; pfam00668 290338002698 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002699 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 290338002700 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 290338002701 acyl-activating enzyme (AAE) consensus motif; other site 290338002702 AMP binding site [chemical binding]; other site 290338002703 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002704 Condensation domain; Region: Condensation; pfam00668 290338002705 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002706 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338002707 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 290338002708 acyl-activating enzyme (AAE) consensus motif; other site 290338002709 AMP binding site [chemical binding]; other site 290338002710 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002711 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338002712 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338002713 active site 290338002714 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002715 Condensation domain; Region: Condensation; pfam00668 290338002716 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002717 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338002718 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 290338002719 acyl-activating enzyme (AAE) consensus motif; other site 290338002720 AMP binding site [chemical binding]; other site 290338002721 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 290338002722 putative FMN binding site [chemical binding]; other site 290338002723 NADPH bind site [chemical binding]; other site 290338002724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338002725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002726 amidase; Provisional; Region: PRK06170 290338002727 Amidase; Region: Amidase; cl11426 290338002728 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 290338002729 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 290338002730 Condensation domain; Region: Condensation; pfam00668 290338002731 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290338002732 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 290338002733 acyl-activating enzyme (AAE) consensus motif; other site 290338002734 AMP binding site [chemical binding]; other site 290338002735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002736 Condensation domain; Region: Condensation; pfam00668 290338002737 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 290338002738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338002739 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338002740 active site 290338002741 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290338002742 Beta-lactamase; Region: Beta-lactamase; pfam00144 290338002743 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 290338002744 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 290338002745 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 290338002746 AAA-like domain; Region: AAA_10; pfam12846 290338002747 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 290338002748 conjugal transfer protein TrbM; Provisional; Region: PRK13893 290338002749 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 290338002750 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 290338002751 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290338002752 Walker A motif; other site 290338002753 hexamer interface [polypeptide binding]; other site 290338002754 ATP binding site [chemical binding]; other site 290338002755 Walker B motif; other site 290338002756 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 290338002757 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 290338002758 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 290338002759 VirB7 interaction site; other site 290338002760 VirB8 protein; Region: VirB8; pfam04335 290338002761 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 290338002762 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 290338002763 Type IV secretion system proteins; Region: T4SS; pfam07996 290338002764 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 290338002765 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 290338002766 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 290338002767 TrbC/VIRB2 family; Region: TrbC; cl01583 290338002768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338002769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338002770 catalytic residue [active] 290338002771 Haemolysin expression modulating protein; Region: HHA; cl11501 290338002772 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 290338002773 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 290338002774 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338002775 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338002776 N-terminal plug; other site 290338002777 ligand-binding site [chemical binding]; other site 290338002778 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 290338002779 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 290338002780 acyl-activating enzyme (AAE) consensus motif; other site 290338002781 active site 290338002782 AMP binding site [chemical binding]; other site 290338002783 substrate binding site [chemical binding]; other site 290338002784 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 290338002785 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 290338002786 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338002787 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338002788 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338002789 active site 290338002790 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338002791 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 290338002792 Methyltransferase domain; Region: Methyltransf_12; pfam08242 290338002793 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 290338002794 KR domain; Region: KR; pfam08659 290338002795 NADP binding site [chemical binding]; other site 290338002796 active site 290338002797 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 290338002798 Condensation domain; Region: Condensation; pfam00668 290338002799 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002800 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338002801 Methyltransferase domain; Region: Methyltransf_12; pfam08242 290338002802 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002803 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 290338002804 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002805 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338002806 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002807 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 290338002808 Condensation domain; Region: Condensation; pfam00668 290338002809 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338002810 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338002811 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 290338002812 acyl-activating enzyme (AAE) consensus motif; other site 290338002813 AMP binding site [chemical binding]; other site 290338002814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338002815 S-adenosylmethionine binding site [chemical binding]; other site 290338002816 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338002817 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338002818 Condensation domain; Region: Condensation; pfam00668 290338002819 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338002820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338002821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338002822 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290338002823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338002824 Walker A/P-loop; other site 290338002825 ATP binding site [chemical binding]; other site 290338002826 Q-loop/lid; other site 290338002827 ABC transporter signature motif; other site 290338002828 Walker B; other site 290338002829 D-loop; other site 290338002830 H-loop/switch region; other site 290338002831 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290338002832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338002833 Walker A/P-loop; other site 290338002834 ATP binding site [chemical binding]; other site 290338002835 Q-loop/lid; other site 290338002836 ABC transporter signature motif; other site 290338002837 Walker B; other site 290338002838 D-loop; other site 290338002839 H-loop/switch region; other site 290338002840 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 290338002841 muropeptide transporter; Validated; Region: ampG; cl17669 290338002842 salicylate synthase Irp9; Reviewed; Region: PRK06772 290338002843 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290338002844 integrase; Provisional; Region: PRK09692 290338002845 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290338002846 active site 290338002847 Int/Topo IB signature motif; other site 290338002848 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 290338002849 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 290338002850 putative ligand binding residues [chemical binding]; other site 290338002851 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338002852 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338002853 ABC-ATPase subunit interface; other site 290338002854 dimer interface [polypeptide binding]; other site 290338002855 putative PBP binding regions; other site 290338002856 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290338002857 putative DNA binding helix; other site 290338002858 dimer interface [polypeptide binding]; other site 290338002859 structural Zn2+ binding site [ion binding]; other site 290338002860 metal binding site 1 [ion binding]; metal-binding site 290338002861 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 290338002862 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 290338002863 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 290338002864 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 290338002865 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 290338002866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290338002867 G1 box; other site 290338002868 GTP/Mg2+ binding site [chemical binding]; other site 290338002869 G2 box; other site 290338002870 Switch I region; other site 290338002871 G3 box; other site 290338002872 Switch II region; other site 290338002873 G4 box; other site 290338002874 G5 box; other site 290338002875 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 290338002876 Nucleoside recognition; Region: Gate; pfam07670 290338002877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290338002878 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290338002879 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290338002880 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290338002881 active site 290338002882 HIGH motif; other site 290338002883 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290338002884 KMSKS motif; other site 290338002885 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 290338002886 tRNA binding surface [nucleotide binding]; other site 290338002887 anticodon binding site; other site 290338002888 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 290338002889 metal binding site 2 [ion binding]; metal-binding site 290338002890 putative DNA binding helix; other site 290338002891 metal binding site 1 [ion binding]; metal-binding site 290338002892 dimer interface [polypeptide binding]; other site 290338002893 structural Zn2+ binding site [ion binding]; other site 290338002894 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 290338002895 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338002896 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 290338002897 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 290338002898 putative GTP cyclohydrolase; Provisional; Region: PRK13674 290338002899 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290338002900 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 290338002901 trimer interface [polypeptide binding]; other site 290338002902 active site 290338002903 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290338002904 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 290338002905 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338002906 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338002907 ABC-ATPase subunit interface; other site 290338002908 dimer interface [polypeptide binding]; other site 290338002909 putative PBP binding regions; other site 290338002910 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338002911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338002912 ABC-ATPase subunit interface; other site 290338002913 dimer interface [polypeptide binding]; other site 290338002914 putative PBP binding regions; other site 290338002915 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290338002916 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290338002917 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 290338002918 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290338002919 metal binding site [ion binding]; metal-binding site 290338002920 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 290338002921 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 290338002922 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 290338002923 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290338002924 active site 290338002925 dimer interface [polypeptide binding]; other site 290338002926 motif 1; other site 290338002927 motif 2; other site 290338002928 motif 3; other site 290338002929 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290338002930 anticodon binding site; other site 290338002931 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 290338002932 putative active site [active] 290338002933 Zn binding site [ion binding]; other site 290338002934 dihydroorotase; Reviewed; Region: PRK09236 290338002935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290338002936 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 290338002937 active site 290338002938 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 290338002939 dimer interface [polypeptide binding]; other site 290338002940 active site 290338002941 aspartate-rich active site metal binding site; other site 290338002942 allosteric magnesium binding site [ion binding]; other site 290338002943 Schiff base residues; other site 290338002944 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290338002945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290338002946 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290338002947 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290338002948 metal binding site [ion binding]; metal-binding site 290338002949 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338002950 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338002951 dimer interface [polypeptide binding]; other site 290338002952 putative PBP binding regions; other site 290338002953 ABC-ATPase subunit interface; other site 290338002954 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290338002955 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290338002956 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 290338002957 integrase; Provisional; Region: PRK09692 290338002958 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290338002959 active site 290338002960 Int/Topo IB signature motif; other site 290338002961 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 290338002962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338002963 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 290338002964 putative dimerization interface [polypeptide binding]; other site 290338002965 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 290338002966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338002967 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 290338002968 putative substrate binding site [chemical binding]; other site 290338002969 dimerization interface [polypeptide binding]; other site 290338002970 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 290338002971 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338002972 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338002973 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338002974 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338002975 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338002976 PapC N-terminal domain; Region: PapC_N; pfam13954 290338002977 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338002978 PapC C-terminal domain; Region: PapC_C; pfam13953 290338002979 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338002980 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338002981 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338002982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338002983 DNA binding residues [nucleotide binding] 290338002984 dimerization interface [polypeptide binding]; other site 290338002985 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 290338002986 Class I aldolases; Region: Aldolase_Class_I; cl17187 290338002987 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338002988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338002989 N-terminal plug; other site 290338002990 ligand-binding site [chemical binding]; other site 290338002991 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 290338002992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338002993 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 290338002994 IucA / IucC family; Region: IucA_IucC; pfam04183 290338002995 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290338002996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290338002997 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290338002998 IucA / IucC family; Region: IucA_IucC; pfam04183 290338002999 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290338003000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338003001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338003002 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290338003003 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290338003004 FAD binding pocket [chemical binding]; other site 290338003005 FAD binding motif [chemical binding]; other site 290338003006 phosphate binding motif [ion binding]; other site 290338003007 NAD binding pocket [chemical binding]; other site 290338003008 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338003009 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338003010 trimer interface [polypeptide binding]; other site 290338003011 eyelet of channel; other site 290338003012 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 290338003013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290338003014 Zn2+ binding site [ion binding]; other site 290338003015 Mg2+ binding site [ion binding]; other site 290338003016 DNA cytosine methylase; Provisional; Region: PRK10458 290338003017 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 290338003018 cofactor binding site; other site 290338003019 DNA binding site [nucleotide binding] 290338003020 substrate interaction site [chemical binding]; other site 290338003021 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 290338003022 additional DNA contacts [nucleotide binding]; other site 290338003023 mismatch recognition site; other site 290338003024 active site 290338003025 zinc binding site [ion binding]; other site 290338003026 DNA intercalation site [nucleotide binding]; other site 290338003027 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 290338003028 EamA-like transporter family; Region: EamA; cl17759 290338003029 EamA-like transporter family; Region: EamA; pfam00892 290338003030 hypothetical protein; Provisional; Region: PRK10062 290338003031 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 290338003032 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 290338003033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338003034 metal binding site [ion binding]; metal-binding site 290338003035 active site 290338003036 I-site; other site 290338003037 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 290338003038 hypothetical protein; Provisional; Region: PRK10708 290338003039 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 290338003040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338003041 DNA binding residues [nucleotide binding] 290338003042 dimerization interface [polypeptide binding]; other site 290338003043 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 290338003044 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 290338003045 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 290338003046 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 290338003047 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 290338003048 flagellar motor switch protein; Validated; Region: fliN; PRK05698 290338003049 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 290338003050 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 290338003051 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 290338003052 flagellar hook-length control protein; Provisional; Region: PRK10118 290338003053 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 290338003054 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 290338003055 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 290338003056 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 290338003057 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 290338003058 Walker A motif/ATP binding site; other site 290338003059 Walker B motif; other site 290338003060 flagellar assembly protein H; Validated; Region: fliH; PRK05687 290338003061 Flagellar assembly protein FliH; Region: FliH; pfam02108 290338003062 flagellar motor switch protein FliG; Region: fliG; TIGR00207 290338003063 FliG C-terminal domain; Region: FliG_C; pfam01706 290338003064 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 290338003065 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 290338003066 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 290338003067 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 290338003068 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 290338003069 CPxP motif; other site 290338003070 putative inner membrane protein; Provisional; Region: PRK11099 290338003071 lipoprotein; Provisional; Region: PRK10397 290338003072 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 290338003073 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 290338003074 active site 290338003075 Na/Ca binding site [ion binding]; other site 290338003076 catalytic site [active] 290338003077 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 290338003078 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 290338003079 flagellar protein FliS; Validated; Region: fliS; PRK05685 290338003080 flagellar capping protein; Reviewed; Region: fliD; PRK08032 290338003081 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 290338003082 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 290338003083 flagellin; Provisional; Region: PRK12802 290338003084 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290338003085 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 290338003086 Methyltransferase domain; Region: Methyltransf_12; pfam08242 290338003087 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 290338003088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338003089 binding surface 290338003090 TPR motif; other site 290338003091 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290338003092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338003093 TPR motif; other site 290338003094 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290338003095 binding surface 290338003096 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 290338003097 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290338003098 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 290338003099 WbqC-like protein family; Region: WbqC; pfam08889 290338003100 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290338003101 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290338003102 inhibitor-cofactor binding pocket; inhibition site 290338003103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338003104 catalytic residue [active] 290338003105 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 290338003106 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338003107 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290338003108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290338003109 DNA binding residues [nucleotide binding] 290338003110 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 290338003111 cystine transporter subunit; Provisional; Region: PRK11260 290338003112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338003113 substrate binding pocket [chemical binding]; other site 290338003114 membrane-bound complex binding site; other site 290338003115 hinge residues; other site 290338003116 D-cysteine desulfhydrase; Validated; Region: PRK03910 290338003117 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 290338003118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338003119 catalytic residue [active] 290338003120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338003121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338003122 dimer interface [polypeptide binding]; other site 290338003123 conserved gate region; other site 290338003124 putative PBP binding loops; other site 290338003125 ABC-ATPase subunit interface; other site 290338003126 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 290338003127 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290338003128 Walker A/P-loop; other site 290338003129 ATP binding site [chemical binding]; other site 290338003130 Q-loop/lid; other site 290338003131 ABC transporter signature motif; other site 290338003132 Walker B; other site 290338003133 D-loop; other site 290338003134 H-loop/switch region; other site 290338003135 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 290338003136 Autoinducer binding domain; Region: Autoind_bind; pfam03472 290338003137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338003138 DNA binding residues [nucleotide binding] 290338003139 dimerization interface [polypeptide binding]; other site 290338003140 hypothetical protein; Provisional; Region: PRK10613 290338003141 response regulator; Provisional; Region: PRK09483 290338003142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338003143 active site 290338003144 phosphorylation site [posttranslational modification] 290338003145 intermolecular recognition site; other site 290338003146 dimerization interface [polypeptide binding]; other site 290338003147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338003148 DNA binding residues [nucleotide binding] 290338003149 dimerization interface [polypeptide binding]; other site 290338003150 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 290338003151 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290338003152 GIY-YIG motif/motif A; other site 290338003153 active site 290338003154 catalytic site [active] 290338003155 putative DNA binding site [nucleotide binding]; other site 290338003156 metal binding site [ion binding]; metal-binding site 290338003157 UvrB/uvrC motif; Region: UVR; pfam02151 290338003158 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290338003159 Helix-hairpin-helix motif; Region: HHH; pfam00633 290338003160 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 290338003161 hypothetical protein; Provisional; Region: PRK10396 290338003162 yecA family protein; Region: ygfB_yecA; TIGR02292 290338003163 SEC-C motif; Region: SEC-C; pfam02810 290338003164 tyrosine transporter TyrP; Provisional; Region: PRK15132 290338003165 aromatic amino acid transport protein; Region: araaP; TIGR00837 290338003166 probable metal-binding protein; Region: matur_matur; TIGR03853 290338003167 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290338003168 Ferritin-like domain; Region: Ferritin; pfam00210 290338003169 ferroxidase diiron center [ion binding]; other site 290338003170 YecR-like lipoprotein; Region: YecR; pfam13992 290338003171 hypothetical protein; Provisional; Region: PRK09273 290338003172 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 290338003173 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 290338003174 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 290338003175 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290338003176 Ferritin-like domain; Region: Ferritin; pfam00210 290338003177 ferroxidase diiron center [ion binding]; other site 290338003178 DJ-1 family protein; Region: not_thiJ; TIGR01383 290338003179 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 290338003180 conserved cys residue [active] 290338003181 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 290338003182 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 290338003183 ligand binding site [chemical binding]; other site 290338003184 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 290338003185 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338003186 Walker A/P-loop; other site 290338003187 ATP binding site [chemical binding]; other site 290338003188 Q-loop/lid; other site 290338003189 ABC transporter signature motif; other site 290338003190 Walker B; other site 290338003191 D-loop; other site 290338003192 H-loop/switch region; other site 290338003193 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338003194 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338003195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338003196 TM-ABC transporter signature motif; other site 290338003197 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 290338003198 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 290338003199 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 290338003200 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 290338003201 active site 290338003202 homotetramer interface [polypeptide binding]; other site 290338003203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338003204 Ligand Binding Site [chemical binding]; other site 290338003205 transcriptional activator FlhD; Provisional; Region: PRK02909 290338003206 transcriptional activator FlhC; Provisional; Region: PRK12722 290338003207 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 290338003208 flagellar motor protein MotA; Validated; Region: PRK09110 290338003209 flagellar motor protein MotB; Validated; Region: motB; PRK09041 290338003210 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 290338003211 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290338003212 ligand binding site [chemical binding]; other site 290338003213 chemotaxis protein CheA; Provisional; Region: PRK10547 290338003214 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290338003215 putative binding surface; other site 290338003216 active site 290338003217 CheY binding; Region: CheY-binding; pfam09078 290338003218 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 290338003219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338003220 ATP binding site [chemical binding]; other site 290338003221 Mg2+ binding site [ion binding]; other site 290338003222 G-X-G motif; other site 290338003223 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 290338003224 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 290338003225 putative CheA interaction surface; other site 290338003226 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338003227 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 290338003228 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 290338003229 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290338003230 dimer interface [polypeptide binding]; other site 290338003231 ligand binding site [chemical binding]; other site 290338003232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338003233 dimerization interface [polypeptide binding]; other site 290338003234 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338003235 dimer interface [polypeptide binding]; other site 290338003236 putative CheW interface [polypeptide binding]; other site 290338003237 methyl-accepting protein IV; Provisional; Region: PRK09793 290338003238 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290338003239 dimer interface [polypeptide binding]; other site 290338003240 ligand binding site [chemical binding]; other site 290338003241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338003242 dimerization interface [polypeptide binding]; other site 290338003243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338003244 dimer interface [polypeptide binding]; other site 290338003245 putative CheW interface [polypeptide binding]; other site 290338003246 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 290338003247 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 290338003248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003249 S-adenosylmethionine binding site [chemical binding]; other site 290338003250 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 290338003251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338003252 active site 290338003253 phosphorylation site [posttranslational modification] 290338003254 intermolecular recognition site; other site 290338003255 dimerization interface [polypeptide binding]; other site 290338003256 CheB methylesterase; Region: CheB_methylest; pfam01339 290338003257 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 290338003258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338003259 active site 290338003260 phosphorylation site [posttranslational modification] 290338003261 intermolecular recognition site; other site 290338003262 dimerization interface [polypeptide binding]; other site 290338003263 chemotaxis regulator CheZ; Provisional; Region: PRK11166 290338003264 Fimbrial protein; Region: Fimbrial; cl01416 290338003265 Fimbrial protein; Region: Fimbrial; pfam00419 290338003266 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338003267 PapC N-terminal domain; Region: PapC_N; pfam13954 290338003268 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338003269 PapC C-terminal domain; Region: PapC_C; pfam13953 290338003270 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338003271 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338003272 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338003273 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338003274 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 290338003275 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 290338003276 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 290338003277 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 290338003278 FHIPEP family; Region: FHIPEP; pfam00771 290338003279 Flagellar protein FlhE; Region: FlhE; pfam06366 290338003280 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290338003281 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290338003282 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 290338003283 penicillin-binding protein 2; Provisional; Region: PRK10795 290338003284 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290338003285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290338003286 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 290338003287 arginyl-tRNA synthetase; Region: argS; TIGR00456 290338003288 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290338003289 active site 290338003290 HIGH motif; other site 290338003291 KMSK motif region; other site 290338003292 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 290338003293 tRNA binding surface [nucleotide binding]; other site 290338003294 anticodon binding site; other site 290338003295 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 290338003296 putative metal binding site [ion binding]; other site 290338003297 copper homeostasis protein CutC; Provisional; Region: PRK11572 290338003298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003299 S-adenosylmethionine binding site [chemical binding]; other site 290338003300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003301 S-adenosylmethionine binding site [chemical binding]; other site 290338003302 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 290338003303 hypothetical protein; Provisional; Region: PRK10302 290338003304 Isochorismatase family; Region: Isochorismatase; pfam00857 290338003305 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 290338003306 catalytic triad [active] 290338003307 conserved cis-peptide bond; other site 290338003308 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290338003309 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290338003310 dimer interface [polypeptide binding]; other site 290338003311 anticodon binding site; other site 290338003312 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 290338003313 homodimer interface [polypeptide binding]; other site 290338003314 motif 1; other site 290338003315 active site 290338003316 motif 2; other site 290338003317 GAD domain; Region: GAD; pfam02938 290338003318 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290338003319 active site 290338003320 motif 3; other site 290338003321 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 290338003322 nudix motif; other site 290338003323 hypothetical protein; Validated; Region: PRK00110 290338003324 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 290338003325 active site 290338003326 putative DNA-binding cleft [nucleotide binding]; other site 290338003327 dimer interface [polypeptide binding]; other site 290338003328 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290338003329 RuvA N terminal domain; Region: RuvA_N; pfam01330 290338003330 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 290338003331 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290338003332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338003333 Walker A motif; other site 290338003334 ATP binding site [chemical binding]; other site 290338003335 Walker B motif; other site 290338003336 arginine finger; other site 290338003337 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290338003338 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338003339 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338003340 ABC-ATPase subunit interface; other site 290338003341 dimer interface [polypeptide binding]; other site 290338003342 putative PBP binding regions; other site 290338003343 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 290338003344 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290338003345 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 290338003346 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 290338003347 metal binding site [ion binding]; metal-binding site 290338003348 putative peptidase; Provisional; Region: PRK11649 290338003349 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338003350 Peptidase family M23; Region: Peptidase_M23; pfam01551 290338003351 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 290338003352 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290338003353 putative acyl-acceptor binding pocket; other site 290338003354 pyruvate kinase; Provisional; Region: PRK05826 290338003355 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 290338003356 domain interfaces; other site 290338003357 active site 290338003358 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 290338003359 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338003360 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338003361 putative active site [active] 290338003362 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290338003363 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290338003364 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290338003365 phosphogluconate dehydratase; Validated; Region: PRK09054 290338003366 6-phosphogluconate dehydratase; Region: edd; TIGR01196 290338003367 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 290338003368 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290338003369 active site 290338003370 intersubunit interface [polypeptide binding]; other site 290338003371 catalytic residue [active] 290338003372 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 290338003373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338003374 ATP-grasp domain; Region: ATP-grasp; pfam02222 290338003375 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 290338003376 hypothetical protein; Provisional; Region: PRK13680 290338003377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 290338003378 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 290338003379 putative metal binding site [ion binding]; other site 290338003380 protease 2; Provisional; Region: PRK10115 290338003381 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290338003382 exodeoxyribonuclease X; Provisional; Region: PRK07983 290338003383 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290338003384 active site 290338003385 catalytic site [active] 290338003386 substrate binding site [chemical binding]; other site 290338003387 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290338003388 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 290338003389 catalytic triad [active] 290338003390 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 290338003391 hypothetical protein; Provisional; Region: PRK10301 290338003392 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 290338003393 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 290338003394 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 290338003395 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 290338003396 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338003397 N-terminal plug; other site 290338003398 ligand-binding site [chemical binding]; other site 290338003399 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 290338003400 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 290338003401 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 290338003402 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 290338003403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003404 S-adenosylmethionine binding site [chemical binding]; other site 290338003405 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 290338003406 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 290338003407 mce related protein; Region: MCE; pfam02470 290338003408 mce related protein; Region: MCE; pfam02470 290338003409 mce related protein; Region: MCE; pfam02470 290338003410 mce related protein; Region: MCE; pfam02470 290338003411 mce related protein; Region: MCE; pfam02470 290338003412 mce related protein; Region: MCE; pfam02470 290338003413 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 290338003414 Paraquat-inducible protein A; Region: PqiA; pfam04403 290338003415 Paraquat-inducible protein A; Region: PqiA; pfam04403 290338003416 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 290338003417 ProP expression regulator; Provisional; Region: PRK04950 290338003418 ProQ/FINO family; Region: ProQ; pfam04352 290338003419 carboxy-terminal protease; Provisional; Region: PRK11186 290338003420 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290338003421 protein binding site [polypeptide binding]; other site 290338003422 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290338003423 Catalytic dyad [active] 290338003424 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 290338003425 heat shock protein HtpX; Provisional; Region: PRK05457 290338003426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338003427 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338003428 putative substrate translocation pore; other site 290338003429 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 290338003430 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290338003431 dimerization interface [polypeptide binding]; other site 290338003432 putative Zn2+ binding site [ion binding]; other site 290338003433 putative DNA binding site [nucleotide binding]; other site 290338003434 Bacterial transcriptional regulator; Region: IclR; pfam01614 290338003435 YobH-like protein; Region: YobH; pfam13996 290338003436 PhoPQ regulatory protein; Provisional; Region: PRK10299 290338003437 YebO-like protein; Region: YebO; pfam13974 290338003438 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290338003439 DNA-binding site [nucleotide binding]; DNA binding site 290338003440 RNA-binding motif; other site 290338003441 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 290338003442 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290338003443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290338003444 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 290338003445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003446 S-adenosylmethionine binding site [chemical binding]; other site 290338003447 hypothetical protein; Provisional; Region: PRK11469 290338003448 Domain of unknown function DUF; Region: DUF204; pfam02659 290338003449 Domain of unknown function DUF; Region: DUF204; pfam02659 290338003450 yybp-ykoy leader 290338003451 hypothetical protein; Provisional; Region: PRK02913 290338003452 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 290338003453 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 290338003454 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 290338003455 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 290338003456 active pocket/dimerization site; other site 290338003457 active site 290338003458 phosphorylation site [posttranslational modification] 290338003459 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 290338003460 active site 290338003461 phosphorylation site [posttranslational modification] 290338003462 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290338003463 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290338003464 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290338003465 Transporter associated domain; Region: CorC_HlyC; smart01091 290338003466 phage resistance protein; Provisional; Region: PRK10551 290338003467 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290338003468 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338003469 L-serine deaminase; Provisional; Region: PRK15023 290338003470 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290338003471 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290338003472 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 290338003473 putative active site [active] 290338003474 putative CoA binding site [chemical binding]; other site 290338003475 nudix motif; other site 290338003476 metal binding site [ion binding]; metal-binding site 290338003477 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 290338003478 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290338003479 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 290338003480 hypothetical protein; Provisional; Region: PRK05114 290338003481 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 290338003482 homotrimer interaction site [polypeptide binding]; other site 290338003483 putative active site [active] 290338003484 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 290338003485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290338003486 DEAD_2; Region: DEAD_2; pfam06733 290338003487 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 290338003488 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 290338003489 Glycoprotease family; Region: Peptidase_M22; pfam00814 290338003490 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 290338003491 ribonuclease D; Provisional; Region: PRK10829 290338003492 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 290338003493 catalytic site [active] 290338003494 putative active site [active] 290338003495 putative substrate binding site [chemical binding]; other site 290338003496 Helicase and RNase D C-terminal; Region: HRDC; smart00341 290338003497 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 290338003498 tartrate dehydrogenase; Region: TTC; TIGR02089 290338003499 transcriptional activator TtdR; Provisional; Region: PRK09801 290338003500 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338003501 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 290338003502 putative effector binding pocket; other site 290338003503 putative dimerization interface [polypeptide binding]; other site 290338003504 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 290338003505 cell division inhibitor MinD; Provisional; Region: PRK10818 290338003506 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 290338003507 Switch I; other site 290338003508 Switch II; other site 290338003509 septum formation inhibitor; Reviewed; Region: minC; PRK03511 290338003510 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 290338003511 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 290338003512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 290338003513 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290338003514 hypothetical protein; Provisional; Region: PRK10691 290338003515 hypothetical protein; Provisional; Region: PRK05170 290338003516 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 290338003517 disulfide bond formation protein B; Provisional; Region: PRK01749 290338003518 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 290338003519 fatty acid metabolism regulator; Provisional; Region: PRK04984 290338003520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338003521 DNA-binding site [nucleotide binding]; DNA binding site 290338003522 FadR C-terminal domain; Region: FadR_C; pfam07840 290338003523 SpoVR family protein; Provisional; Region: PRK11767 290338003524 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 290338003525 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 290338003526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338003527 alanine racemase; Reviewed; Region: dadX; PRK03646 290338003528 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 290338003529 active site 290338003530 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290338003531 substrate binding site [chemical binding]; other site 290338003532 catalytic residues [active] 290338003533 dimer interface [polypeptide binding]; other site 290338003534 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 290338003535 TrkA-C domain; Region: TrkA_C; pfam02080 290338003536 Transporter associated domain; Region: CorC_HlyC; smart01091 290338003537 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 290338003538 dimer interface [polypeptide binding]; other site 290338003539 catalytic triad [active] 290338003540 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 290338003541 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338003542 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338003543 catalytic residue [active] 290338003544 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 290338003545 Flagellar regulator YcgR; Region: YcgR; pfam07317 290338003546 PilZ domain; Region: PilZ; pfam07238 290338003547 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 290338003548 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 290338003549 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338003550 N-terminal plug; other site 290338003551 ligand-binding site [chemical binding]; other site 290338003552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 290338003553 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338003554 N-terminal plug; other site 290338003555 ligand-binding site [chemical binding]; other site 290338003556 molybdenum transport protein ModD; Provisional; Region: PRK06096 290338003557 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 290338003558 dimerization interface [polypeptide binding]; other site 290338003559 active site 290338003560 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290338003561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003562 S-adenosylmethionine binding site [chemical binding]; other site 290338003563 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290338003564 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338003565 Walker A/P-loop; other site 290338003566 ATP binding site [chemical binding]; other site 290338003567 Q-loop/lid; other site 290338003568 ABC transporter signature motif; other site 290338003569 Walker B; other site 290338003570 D-loop; other site 290338003571 H-loop/switch region; other site 290338003572 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338003573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338003574 ABC-ATPase subunit interface; other site 290338003575 dimer interface [polypeptide binding]; other site 290338003576 putative PBP binding regions; other site 290338003577 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 290338003578 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 290338003579 putative metal binding site [ion binding]; other site 290338003580 trehalase; Provisional; Region: treA; PRK13271 290338003581 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 290338003582 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 290338003583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 290338003584 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290338003585 dimerization domain swap beta strand [polypeptide binding]; other site 290338003586 regulatory protein interface [polypeptide binding]; other site 290338003587 active site 290338003588 regulatory phosphorylation site [posttranslational modification]; other site 290338003589 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290338003590 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290338003591 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 290338003592 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 290338003593 Dak1 domain; Region: Dak1; pfam02733 290338003594 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290338003595 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 290338003596 flexible hinge region; other site 290338003597 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 290338003598 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338003599 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338003600 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338003601 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338003602 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338003603 PapC N-terminal domain; Region: PapC_N; pfam13954 290338003604 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338003605 PapC C-terminal domain; Region: PapC_C; pfam13953 290338003606 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338003607 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338003608 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 290338003609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338003610 DNA binding residues [nucleotide binding] 290338003611 dimerization interface [polypeptide binding]; other site 290338003612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338003613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338003614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290338003615 dimerization interface [polypeptide binding]; other site 290338003616 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290338003617 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290338003618 putative molybdopterin cofactor binding site [chemical binding]; other site 290338003619 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290338003620 putative molybdopterin cofactor binding site; other site 290338003621 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 290338003622 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290338003623 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290338003624 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 290338003625 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 290338003626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338003627 FeS/SAM binding site; other site 290338003628 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290338003629 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 290338003630 Uncharacterized conserved protein [Function unknown]; Region: COG3268 290338003631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338003632 NAD(P) binding site [chemical binding]; other site 290338003633 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 290338003634 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 290338003635 NAD(P) binding site [chemical binding]; other site 290338003636 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 290338003637 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290338003638 putative NAD(P) binding site [chemical binding]; other site 290338003639 putative active site [active] 290338003640 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 290338003641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290338003642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338003643 Coenzyme A binding pocket [chemical binding]; other site 290338003644 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290338003645 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290338003646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 290338003647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290338003648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338003649 Coenzyme A binding pocket [chemical binding]; other site 290338003650 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338003651 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338003652 N-terminal plug; other site 290338003653 ligand-binding site [chemical binding]; other site 290338003654 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 290338003655 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 290338003656 acyl-activating enzyme (AAE) consensus motif; other site 290338003657 active site 290338003658 AMP binding site [chemical binding]; other site 290338003659 substrate binding site [chemical binding]; other site 290338003660 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 290338003661 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 290338003662 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338003663 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 290338003664 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 290338003665 active site 290338003666 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338003667 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 290338003668 Methyltransferase domain; Region: Methyltransf_12; pfam08242 290338003669 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 290338003670 KR domain; Region: KR; pfam08659 290338003671 NADP binding site [chemical binding]; other site 290338003672 active site 290338003673 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 290338003674 Condensation domain; Region: Condensation; pfam00668 290338003675 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338003676 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338003677 Methyltransferase domain; Region: Methyltransf_12; pfam08242 290338003678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338003679 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 290338003680 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 290338003681 Condensation domain; Region: Condensation; pfam00668 290338003682 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338003683 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338003684 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 290338003685 acyl-activating enzyme (AAE) consensus motif; other site 290338003686 AMP binding site [chemical binding]; other site 290338003687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003688 S-adenosylmethionine binding site [chemical binding]; other site 290338003689 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338003690 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338003691 Condensation domain; Region: Condensation; pfam00668 290338003692 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290338003693 Nonribosomal peptide synthase; Region: NRPS; pfam08415 290338003694 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338003695 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338003696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338003697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338003698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290338003699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338003700 Walker A/P-loop; other site 290338003701 ATP binding site [chemical binding]; other site 290338003702 Q-loop/lid; other site 290338003703 ABC transporter signature motif; other site 290338003704 Walker B; other site 290338003705 D-loop; other site 290338003706 H-loop/switch region; other site 290338003707 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290338003708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338003709 Walker A/P-loop; other site 290338003710 ATP binding site [chemical binding]; other site 290338003711 Q-loop/lid; other site 290338003712 ABC transporter signature motif; other site 290338003713 Walker B; other site 290338003714 D-loop; other site 290338003715 H-loop/switch region; other site 290338003716 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 290338003717 muropeptide transporter; Validated; Region: ampG; cl17669 290338003718 salicylate synthase Irp9; Reviewed; Region: PRK06772 290338003719 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290338003720 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 290338003721 GTP-binding protein YchF; Reviewed; Region: PRK09601 290338003722 YchF GTPase; Region: YchF; cd01900 290338003723 G1 box; other site 290338003724 GTP/Mg2+ binding site [chemical binding]; other site 290338003725 Switch I region; other site 290338003726 G2 box; other site 290338003727 Switch II region; other site 290338003728 G3 box; other site 290338003729 G4 box; other site 290338003730 G5 box; other site 290338003731 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290338003732 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290338003733 putative active site [active] 290338003734 catalytic residue [active] 290338003735 hypothetical protein; Provisional; Region: PRK10692 290338003736 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 290338003737 cytochrome b; Provisional; Region: CYTB; MTH00191 290338003738 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 290338003739 heme bH binding site [chemical binding]; other site 290338003740 Qi binding site; other site 290338003741 intrachain domain interface; other site 290338003742 heme bL binding site [chemical binding]; other site 290338003743 interchain domain interface [polypeptide binding]; other site 290338003744 Qo binding site; other site 290338003745 intrachain domain interface; other site 290338003746 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 290338003747 Qo binding site; other site 290338003748 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 290338003749 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 290338003750 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 290338003751 [2Fe-2S] cluster binding site [ion binding]; other site 290338003752 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 290338003753 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 290338003754 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290338003755 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338003756 Walker A/P-loop; other site 290338003757 ATP binding site [chemical binding]; other site 290338003758 Q-loop/lid; other site 290338003759 ABC transporter signature motif; other site 290338003760 Walker B; other site 290338003761 D-loop; other site 290338003762 H-loop/switch region; other site 290338003763 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338003764 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338003765 ABC-ATPase subunit interface; other site 290338003766 dimer interface [polypeptide binding]; other site 290338003767 putative PBP binding regions; other site 290338003768 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 290338003769 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 290338003770 putative ligand binding residues [chemical binding]; other site 290338003771 cobalamin riboswitch 290338003772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338003773 Coenzyme A binding pocket [chemical binding]; other site 290338003774 putative transporter; Provisional; Region: PRK11660 290338003775 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290338003776 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290338003777 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290338003778 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 290338003779 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290338003780 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338003781 active site 290338003782 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 290338003783 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290338003784 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290338003785 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 290338003786 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 290338003787 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290338003788 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 290338003789 tRNA; other site 290338003790 putative tRNA binding site [nucleotide binding]; other site 290338003791 putative NADP binding site [chemical binding]; other site 290338003792 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290338003793 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290338003794 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290338003795 RF-1 domain; Region: RF-1; pfam00472 290338003796 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290338003797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338003798 hypothetical protein; Provisional; Region: PRK10278 290338003799 hypothetical protein; Provisional; Region: PRK10941 290338003800 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 290338003801 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 290338003802 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290338003803 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 290338003804 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290338003805 cation transport regulator; Reviewed; Region: chaB; PRK09582 290338003806 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 290338003807 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 290338003808 putative active site pocket [active] 290338003809 dimerization interface [polypeptide binding]; other site 290338003810 putative catalytic residue [active] 290338003811 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 290338003812 Cache domain; Region: Cache_1; pfam02743 290338003813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338003814 dimerization interface [polypeptide binding]; other site 290338003815 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338003816 dimer interface [polypeptide binding]; other site 290338003817 putative CheW interface [polypeptide binding]; other site 290338003818 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 290338003819 Nitrate and nitrite sensing; Region: NIT; pfam08376 290338003820 ANTAR domain; Region: ANTAR; pfam03861 290338003821 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290338003822 NMT1-like family; Region: NMT1_2; pfam13379 290338003823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290338003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338003825 dimer interface [polypeptide binding]; other site 290338003826 conserved gate region; other site 290338003827 putative PBP binding loops; other site 290338003828 ABC-ATPase subunit interface; other site 290338003829 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290338003830 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290338003831 Walker A/P-loop; other site 290338003832 ATP binding site [chemical binding]; other site 290338003833 Q-loop/lid; other site 290338003834 ABC transporter signature motif; other site 290338003835 Walker B; other site 290338003836 D-loop; other site 290338003837 H-loop/switch region; other site 290338003838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290338003839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338003840 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290338003841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338003842 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290338003843 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290338003844 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290338003845 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290338003846 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 290338003847 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290338003848 [4Fe-4S] binding site [ion binding]; other site 290338003849 molybdopterin cofactor binding site; other site 290338003850 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 290338003851 molybdopterin cofactor binding site; other site 290338003852 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290338003853 putative invasin; Provisional; Region: PRK10177 290338003854 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 290338003855 transcriptional regulator NarL; Provisional; Region: PRK10651 290338003856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338003857 active site 290338003858 phosphorylation site [posttranslational modification] 290338003859 intermolecular recognition site; other site 290338003860 dimerization interface [polypeptide binding]; other site 290338003861 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338003862 DNA binding residues [nucleotide binding] 290338003863 dimerization interface [polypeptide binding]; other site 290338003864 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 290338003865 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 290338003866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338003867 dimerization interface [polypeptide binding]; other site 290338003868 Histidine kinase; Region: HisKA_3; pfam07730 290338003869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338003870 ATP binding site [chemical binding]; other site 290338003871 Mg2+ binding site [ion binding]; other site 290338003872 G-X-G motif; other site 290338003873 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 290338003874 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 290338003875 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 290338003876 [4Fe-4S] binding site [ion binding]; other site 290338003877 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338003878 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338003879 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338003880 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 290338003881 molybdopterin cofactor binding site; other site 290338003882 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 290338003883 4Fe-4S binding domain; Region: Fer4; cl02805 290338003884 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 290338003885 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 290338003886 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290338003887 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290338003888 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290338003889 putative active site [active] 290338003890 putative substrate binding site [chemical binding]; other site 290338003891 putative cosubstrate binding site; other site 290338003892 catalytic site [active] 290338003893 hypothetical protein; Provisional; Region: PRK01617 290338003894 hypothetical protein; Provisional; Region: PRK10279 290338003895 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 290338003896 active site 290338003897 nucleophile elbow; other site 290338003898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338003899 active site 290338003900 response regulator of RpoS; Provisional; Region: PRK10693 290338003901 phosphorylation site [posttranslational modification] 290338003902 intermolecular recognition site; other site 290338003903 dimerization interface [polypeptide binding]; other site 290338003904 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290338003905 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290338003906 active site 290338003907 tetramer interface; other site 290338003908 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 290338003909 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 290338003910 thymidine kinase; Provisional; Region: PRK04296 290338003911 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 290338003912 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 290338003913 putative catalytic cysteine [active] 290338003914 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 290338003915 putative active site [active] 290338003916 metal binding site [ion binding]; metal-binding site 290338003917 hypothetical protein; Provisional; Region: PRK11111 290338003918 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 290338003919 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 290338003920 peptide binding site [polypeptide binding]; other site 290338003921 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 290338003922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338003923 dimer interface [polypeptide binding]; other site 290338003924 conserved gate region; other site 290338003925 putative PBP binding loops; other site 290338003926 ABC-ATPase subunit interface; other site 290338003927 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 290338003928 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290338003929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338003930 dimer interface [polypeptide binding]; other site 290338003931 conserved gate region; other site 290338003932 ABC-ATPase subunit interface; other site 290338003933 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 290338003934 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338003935 Walker A/P-loop; other site 290338003936 ATP binding site [chemical binding]; other site 290338003937 Q-loop/lid; other site 290338003938 ABC transporter signature motif; other site 290338003939 Walker B; other site 290338003940 D-loop; other site 290338003941 H-loop/switch region; other site 290338003942 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290338003943 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 290338003944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338003945 Walker A/P-loop; other site 290338003946 ATP binding site [chemical binding]; other site 290338003947 Q-loop/lid; other site 290338003948 ABC transporter signature motif; other site 290338003949 Walker B; other site 290338003950 D-loop; other site 290338003951 H-loop/switch region; other site 290338003952 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290338003953 dsDNA-mimic protein; Reviewed; Region: PRK05094 290338003954 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290338003955 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290338003956 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290338003957 putative active site [active] 290338003958 catalytic site [active] 290338003959 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290338003960 putative active site [active] 290338003961 catalytic site [active] 290338003962 YciI-like protein; Reviewed; Region: PRK11370 290338003963 transport protein TonB; Provisional; Region: PRK10819 290338003964 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 290338003965 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290338003966 intracellular septation protein A; Reviewed; Region: PRK00259 290338003967 hypothetical protein; Provisional; Region: PRK02868 290338003968 outer membrane protein W; Provisional; Region: PRK10959 290338003969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338003970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338003971 metal binding site [ion binding]; metal-binding site 290338003972 active site 290338003973 I-site; other site 290338003974 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 290338003975 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290338003976 substrate binding site [chemical binding]; other site 290338003977 active site 290338003978 catalytic residues [active] 290338003979 heterodimer interface [polypeptide binding]; other site 290338003980 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 290338003981 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290338003982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338003983 catalytic residue [active] 290338003984 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 290338003985 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290338003986 active site 290338003987 ribulose/triose binding site [chemical binding]; other site 290338003988 phosphate binding site [ion binding]; other site 290338003989 substrate (anthranilate) binding pocket [chemical binding]; other site 290338003990 product (indole) binding pocket [chemical binding]; other site 290338003991 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 290338003992 active site 290338003993 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 290338003994 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290338003995 glutamine binding [chemical binding]; other site 290338003996 catalytic triad [active] 290338003997 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290338003998 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290338003999 anthranilate synthase component I; Provisional; Region: PRK13564 290338004000 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290338004001 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290338004002 tryptophan operon leader 290338004003 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290338004004 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290338004005 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290338004006 hypothetical protein; Provisional; Region: PRK11630 290338004007 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 290338004008 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338004009 RNA binding surface [nucleotide binding]; other site 290338004010 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 290338004011 probable active site [active] 290338004012 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 290338004013 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 290338004014 homodimer interface [polypeptide binding]; other site 290338004015 Walker A motif; other site 290338004016 ATP binding site [chemical binding]; other site 290338004017 hydroxycobalamin binding site [chemical binding]; other site 290338004018 Walker B motif; other site 290338004019 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 290338004020 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 290338004021 NADP binding site [chemical binding]; other site 290338004022 homodimer interface [polypeptide binding]; other site 290338004023 active site 290338004024 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 290338004025 putative inner membrane peptidase; Provisional; Region: PRK11778 290338004026 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 290338004027 tandem repeat interface [polypeptide binding]; other site 290338004028 oligomer interface [polypeptide binding]; other site 290338004029 active site residues [active] 290338004030 hypothetical protein; Provisional; Region: PRK11037 290338004031 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 290338004032 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290338004033 active site 290338004034 interdomain interaction site; other site 290338004035 putative metal-binding site [ion binding]; other site 290338004036 nucleotide binding site [chemical binding]; other site 290338004037 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290338004038 domain I; other site 290338004039 DNA binding groove [nucleotide binding] 290338004040 phosphate binding site [ion binding]; other site 290338004041 domain II; other site 290338004042 domain III; other site 290338004043 nucleotide binding site [chemical binding]; other site 290338004044 catalytic site [active] 290338004045 domain IV; other site 290338004046 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290338004047 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290338004048 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 290338004049 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 290338004050 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 290338004051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338004052 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 290338004053 substrate binding site [chemical binding]; other site 290338004054 putative dimerization interface [polypeptide binding]; other site 290338004055 aconitate hydratase; Validated; Region: PRK09277 290338004056 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 290338004057 substrate binding site [chemical binding]; other site 290338004058 ligand binding site [chemical binding]; other site 290338004059 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290338004060 substrate binding site [chemical binding]; other site 290338004061 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 290338004062 dimerization interface [polypeptide binding]; other site 290338004063 active site 290338004064 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290338004065 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 290338004066 active site 290338004067 Predicted membrane protein [Function unknown]; Region: COG3771 290338004068 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 290338004069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290338004070 TPR motif; other site 290338004071 binding surface 290338004072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338004073 binding surface 290338004074 TPR motif; other site 290338004075 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 290338004076 active site 290338004077 dimer interface [polypeptide binding]; other site 290338004078 translation initiation factor Sui1; Validated; Region: PRK06824 290338004079 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 290338004080 putative rRNA binding site [nucleotide binding]; other site 290338004081 lipoprotein; Provisional; Region: PRK10540 290338004082 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290338004083 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290338004084 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338004085 hypothetical protein; Provisional; Region: PRK13658 290338004086 RNase II stability modulator; Provisional; Region: PRK10060 290338004087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338004088 putative active site [active] 290338004089 heme pocket [chemical binding]; other site 290338004090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338004091 metal binding site [ion binding]; metal-binding site 290338004092 active site 290338004093 I-site; other site 290338004094 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338004095 exoribonuclease II; Provisional; Region: PRK05054 290338004096 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 290338004097 RNB domain; Region: RNB; pfam00773 290338004098 S1 RNA binding domain; Region: S1; pfam00575 290338004099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 290338004100 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290338004101 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 290338004102 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 290338004103 NAD binding site [chemical binding]; other site 290338004104 homotetramer interface [polypeptide binding]; other site 290338004105 homodimer interface [polypeptide binding]; other site 290338004106 substrate binding site [chemical binding]; other site 290338004107 active site 290338004108 SdiA-regulated; Region: SdiA-regulated; pfam06977 290338004109 SdiA-regulated; Region: SdiA-regulated; cd09971 290338004110 putative active site [active] 290338004111 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 290338004112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338004113 Walker A/P-loop; other site 290338004114 ATP binding site [chemical binding]; other site 290338004115 Q-loop/lid; other site 290338004116 ABC transporter signature motif; other site 290338004117 Walker B; other site 290338004118 D-loop; other site 290338004119 H-loop/switch region; other site 290338004120 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 290338004121 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338004122 Walker A/P-loop; other site 290338004123 ATP binding site [chemical binding]; other site 290338004124 Q-loop/lid; other site 290338004125 ABC transporter signature motif; other site 290338004126 Walker B; other site 290338004127 D-loop; other site 290338004128 H-loop/switch region; other site 290338004129 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338004130 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 290338004131 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290338004132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004133 dimer interface [polypeptide binding]; other site 290338004134 conserved gate region; other site 290338004135 putative PBP binding loops; other site 290338004136 ABC-ATPase subunit interface; other site 290338004137 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 290338004138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004139 dimer interface [polypeptide binding]; other site 290338004140 conserved gate region; other site 290338004141 putative PBP binding loops; other site 290338004142 ABC-ATPase subunit interface; other site 290338004143 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 290338004144 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290338004145 peptide binding site [polypeptide binding]; other site 290338004146 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 290338004147 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 290338004148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338004149 Walker A motif; other site 290338004150 ATP binding site [chemical binding]; other site 290338004151 Walker B motif; other site 290338004152 arginine finger; other site 290338004153 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338004154 phage shock protein PspA; Provisional; Region: PRK10698 290338004155 phage shock protein B; Provisional; Region: pspB; PRK09458 290338004156 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 290338004157 phage shock protein C; Region: phageshock_pspC; TIGR02978 290338004158 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 290338004159 Predicted ATPase [General function prediction only]; Region: COG3106 290338004160 hypothetical protein; Provisional; Region: PRK05415 290338004161 TIGR01620 family protein; Region: hyp_HI0043 290338004162 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 290338004163 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290338004164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338004165 Walker A motif; other site 290338004166 ATP binding site [chemical binding]; other site 290338004167 Walker B motif; other site 290338004168 arginine finger; other site 290338004169 galactoside permease; Reviewed; Region: lacY; PRK09528 290338004170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004171 putative substrate translocation pore; other site 290338004172 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 290338004173 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338004174 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290338004175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338004176 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 290338004177 dimer interface [polypeptide binding]; other site 290338004178 catalytic triad [active] 290338004179 peroxidatic and resolving cysteines [active] 290338004180 Glucan phosphorylase [Carbohydrate transport and metabolism]; Region: GlgP; COG0058 290338004181 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 290338004182 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 290338004183 active site 290338004184 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 290338004185 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 290338004186 putative active site [active] 290338004187 Zn binding site [ion binding]; other site 290338004188 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 290338004189 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 290338004190 peptide binding site [polypeptide binding]; other site 290338004191 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290338004192 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290338004193 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 290338004194 universal stress protein UspE; Provisional; Region: PRK11175 290338004195 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338004196 Ligand Binding Site [chemical binding]; other site 290338004197 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338004198 Ligand Binding Site [chemical binding]; other site 290338004199 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 290338004200 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290338004201 ligand binding site [chemical binding]; other site 290338004202 flexible hinge region; other site 290338004203 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290338004204 putative switch regulator; other site 290338004205 non-specific DNA interactions [nucleotide binding]; other site 290338004206 DNA binding site [nucleotide binding] 290338004207 sequence specific DNA binding site [nucleotide binding]; other site 290338004208 putative cAMP binding site [chemical binding]; other site 290338004209 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 290338004210 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 290338004211 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290338004212 DNA binding site [nucleotide binding] 290338004213 active site 290338004214 AbgT putative transporter family; Region: ABG_transport; cl17431 290338004215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 290338004216 Smr domain; Region: Smr; pfam01713 290338004217 PAS domain S-box; Region: sensory_box; TIGR00229 290338004218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338004219 putative active site [active] 290338004220 heme pocket [chemical binding]; other site 290338004221 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338004222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338004223 metal binding site [ion binding]; metal-binding site 290338004224 active site 290338004225 I-site; other site 290338004226 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290338004227 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 290338004228 Cl binding site [ion binding]; other site 290338004229 oligomer interface [polypeptide binding]; other site 290338004230 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 290338004231 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290338004232 ATP binding site [chemical binding]; other site 290338004233 Mg++ binding site [ion binding]; other site 290338004234 motif III; other site 290338004235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338004236 nucleotide binding region [chemical binding]; other site 290338004237 ATP-binding site [chemical binding]; other site 290338004238 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 290338004239 putative RNA binding site [nucleotide binding]; other site 290338004240 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 290338004241 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 290338004242 Ligand Binding Site [chemical binding]; other site 290338004243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338004244 Ligand Binding Site [chemical binding]; other site 290338004245 KTSC domain; Region: KTSC; pfam13619 290338004246 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338004247 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338004248 trimer interface [polypeptide binding]; other site 290338004249 eyelet of channel; other site 290338004250 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 290338004251 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290338004252 dimer interface [polypeptide binding]; other site 290338004253 PYR/PP interface [polypeptide binding]; other site 290338004254 TPP binding site [chemical binding]; other site 290338004255 substrate binding site [chemical binding]; other site 290338004256 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 290338004257 Domain of unknown function; Region: EKR; smart00890 290338004258 4Fe-4S binding domain; Region: Fer4_6; pfam12837 290338004259 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338004260 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 290338004261 TPP-binding site [chemical binding]; other site 290338004262 dimer interface [polypeptide binding]; other site 290338004263 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 290338004264 Domain of unknown function (DUF333); Region: DUF333; pfam03891 290338004265 heat-inducible protein; Provisional; Region: PRK10449 290338004266 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 290338004267 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290338004268 putative ligand binding site [chemical binding]; other site 290338004269 putative NAD binding site [chemical binding]; other site 290338004270 catalytic site [active] 290338004271 YadA-like C-terminal region; Region: YadA; pfam03895 290338004272 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338004273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338004274 DNA binding residues [nucleotide binding] 290338004275 dimerization interface [polypeptide binding]; other site 290338004276 Protein of unknown function, DUF417; Region: DUF417; cl01162 290338004277 hypothetical protein; Provisional; Region: PRK10695 290338004278 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 290338004279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 290338004280 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338004281 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338004282 active site 290338004283 catalytic tetrad [active] 290338004284 azoreductase; Reviewed; Region: PRK00170 290338004285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290338004286 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 290338004287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338004288 ATP binding site [chemical binding]; other site 290338004289 putative Mg++ binding site [ion binding]; other site 290338004290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338004291 nucleotide binding region [chemical binding]; other site 290338004292 ATP-binding site [chemical binding]; other site 290338004293 Helicase associated domain (HA2); Region: HA2; pfam04408 290338004294 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 290338004295 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 290338004296 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 290338004297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338004298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338004299 dimerization interface [polypeptide binding]; other site 290338004300 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290338004301 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290338004302 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 290338004303 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338004304 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338004305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004306 putative substrate translocation pore; other site 290338004307 Uncharacterized conserved protein [Function unknown]; Region: COG1434 290338004308 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290338004309 putative active site [active] 290338004310 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 290338004311 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290338004312 NAD binding site [chemical binding]; other site 290338004313 catalytic residues [active] 290338004314 substrate binding site [chemical binding]; other site 290338004315 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290338004316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290338004317 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 290338004318 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290338004319 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290338004320 cytochrome b561; Provisional; Region: PRK11513 290338004321 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 290338004322 putative metal binding site [ion binding]; other site 290338004323 putative homodimer interface [polypeptide binding]; other site 290338004324 putative homotetramer interface [polypeptide binding]; other site 290338004325 putative homodimer-homodimer interface [polypeptide binding]; other site 290338004326 putative allosteric switch controlling residues; other site 290338004327 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 290338004328 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 290338004329 substrate binding site [chemical binding]; other site 290338004330 catalytic Zn binding site [ion binding]; other site 290338004331 NAD binding site [chemical binding]; other site 290338004332 structural Zn binding site [ion binding]; other site 290338004333 dimer interface [polypeptide binding]; other site 290338004334 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290338004335 dimer interface [polypeptide binding]; other site 290338004336 ligand binding site [chemical binding]; other site 290338004337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290338004338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338004339 dimer interface [polypeptide binding]; other site 290338004340 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 290338004341 putative CheW interface [polypeptide binding]; other site 290338004342 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 290338004343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338004344 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 290338004345 putative dimerization interface [polypeptide binding]; other site 290338004346 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 290338004347 DHH family; Region: DHH; pfam01368 290338004348 DHHA2 domain; Region: DHHA2; pfam02833 290338004349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 290338004350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 290338004351 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 290338004352 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 290338004353 substrate binding pocket [chemical binding]; other site 290338004354 catalytic triad [active] 290338004355 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 290338004356 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 290338004357 hypothetical protein; Provisional; Region: PRK11415 290338004358 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290338004359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338004360 Coenzyme A binding pocket [chemical binding]; other site 290338004361 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290338004362 putative trimer interface [polypeptide binding]; other site 290338004363 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290338004364 putative trimer interface [polypeptide binding]; other site 290338004365 putative CoA binding site [chemical binding]; other site 290338004366 putative CoA binding site [chemical binding]; other site 290338004367 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 290338004368 putative trimer interface [polypeptide binding]; other site 290338004369 putative CoA binding site [chemical binding]; other site 290338004370 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 290338004371 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 290338004372 gating phenylalanine in ion channel; other site 290338004373 tellurite resistance protein TehB; Provisional; Region: PRK11207 290338004374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338004375 S-adenosylmethionine binding site [chemical binding]; other site 290338004376 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 290338004377 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290338004378 EamA-like transporter family; Region: EamA; pfam00892 290338004379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338004380 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338004381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338004382 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 290338004383 benzoate transporter; Region: benE; TIGR00843 290338004384 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290338004385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338004386 non-specific DNA binding site [nucleotide binding]; other site 290338004387 salt bridge; other site 290338004388 sequence-specific DNA binding site [nucleotide binding]; other site 290338004389 Cupin domain; Region: Cupin_2; pfam07883 290338004390 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290338004391 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290338004392 Peptidase family U32; Region: Peptidase_U32; pfam01136 290338004393 Collagenase; Region: DUF3656; pfam12392 290338004394 YcfA-like protein; Region: YcfA; pfam07927 290338004395 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 290338004396 non-specific DNA binding site [nucleotide binding]; other site 290338004397 salt bridge; other site 290338004398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290338004399 sequence-specific DNA binding site [nucleotide binding]; other site 290338004400 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290338004401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338004402 DNA-binding site [nucleotide binding]; DNA binding site 290338004403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338004404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338004405 homodimer interface [polypeptide binding]; other site 290338004406 catalytic residue [active] 290338004407 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290338004408 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290338004409 tetrameric interface [polypeptide binding]; other site 290338004410 NAD binding site [chemical binding]; other site 290338004411 catalytic residues [active] 290338004412 substrate binding site [chemical binding]; other site 290338004413 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 290338004414 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 290338004415 Virulence factor SrfB; Region: SrfB; pfam07520 290338004416 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290338004417 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290338004418 peptide binding site [polypeptide binding]; other site 290338004419 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 290338004420 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 290338004421 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 290338004422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338004423 Coenzyme A binding pocket [chemical binding]; other site 290338004424 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290338004425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338004426 sequence-specific DNA binding site [nucleotide binding]; other site 290338004427 salt bridge; other site 290338004428 Cupin domain; Region: Cupin_2; pfam07883 290338004429 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 290338004430 Prostaglandin dehydrogenases; Region: PGDH; cd05288 290338004431 NAD(P) binding site [chemical binding]; other site 290338004432 substrate binding site [chemical binding]; other site 290338004433 dimer interface [polypeptide binding]; other site 290338004434 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 290338004435 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338004436 N-terminal plug; other site 290338004437 ligand-binding site [chemical binding]; other site 290338004438 Uncharacterized conserved protein [Function unknown]; Region: COG3391 290338004439 L-asparagine permease; Provisional; Region: PRK15049 290338004440 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 290338004441 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 290338004442 C-terminal domain interface [polypeptide binding]; other site 290338004443 GSH binding site (G-site) [chemical binding]; other site 290338004444 dimer interface [polypeptide binding]; other site 290338004445 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 290338004446 dimer interface [polypeptide binding]; other site 290338004447 N-terminal domain interface [polypeptide binding]; other site 290338004448 substrate binding pocket (H-site) [chemical binding]; other site 290338004449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338004450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338004451 metal binding site [ion binding]; metal-binding site 290338004452 active site 290338004453 I-site; other site 290338004454 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 290338004455 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 290338004456 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 290338004457 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 290338004458 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 290338004459 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 290338004460 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 290338004461 [4Fe-4S] binding site [ion binding]; other site 290338004462 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338004463 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338004464 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338004465 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 290338004466 molybdopterin cofactor binding site; other site 290338004467 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 290338004468 TetR family transcriptional regulator; Provisional; Region: PRK14996 290338004469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338004470 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 290338004471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004472 putative substrate translocation pore; other site 290338004473 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338004474 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338004475 trimer interface [polypeptide binding]; other site 290338004476 eyelet of channel; other site 290338004477 aromatic amino acid exporter; Provisional; Region: PRK11689 290338004478 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 290338004479 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 290338004480 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 290338004481 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 290338004482 malate dehydrogenase; Provisional; Region: PRK13529 290338004483 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290338004484 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 290338004485 NAD(P) binding site [chemical binding]; other site 290338004486 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 290338004487 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290338004488 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338004489 Walker A/P-loop; other site 290338004490 ATP binding site [chemical binding]; other site 290338004491 Q-loop/lid; other site 290338004492 ABC transporter signature motif; other site 290338004493 Walker B; other site 290338004494 D-loop; other site 290338004495 H-loop/switch region; other site 290338004496 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338004497 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290338004498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338004499 Walker A/P-loop; other site 290338004500 ATP binding site [chemical binding]; other site 290338004501 Q-loop/lid; other site 290338004502 ABC transporter signature motif; other site 290338004503 Walker B; other site 290338004504 D-loop; other site 290338004505 H-loop/switch region; other site 290338004506 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338004507 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 290338004508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004509 dimer interface [polypeptide binding]; other site 290338004510 conserved gate region; other site 290338004511 putative PBP binding loops; other site 290338004512 ABC-ATPase subunit interface; other site 290338004513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290338004514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004515 dimer interface [polypeptide binding]; other site 290338004516 conserved gate region; other site 290338004517 putative PBP binding loops; other site 290338004518 ABC-ATPase subunit interface; other site 290338004519 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 290338004520 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290338004521 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 290338004522 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290338004523 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338004524 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290338004525 Cache domain; Region: Cache_1; pfam02743 290338004526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338004527 dimerization interface [polypeptide binding]; other site 290338004528 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338004529 dimer interface [polypeptide binding]; other site 290338004530 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 290338004531 putative CheW interface [polypeptide binding]; other site 290338004532 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290338004533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338004534 non-specific DNA binding site [nucleotide binding]; other site 290338004535 salt bridge; other site 290338004536 sequence-specific DNA binding site [nucleotide binding]; other site 290338004537 HipA N-terminal domain; Region: Couple_hipA; cl11853 290338004538 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290338004539 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290338004540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 290338004541 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 290338004542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338004543 Walker A/P-loop; other site 290338004544 ATP binding site [chemical binding]; other site 290338004545 Q-loop/lid; other site 290338004546 ABC transporter signature motif; other site 290338004547 Walker B; other site 290338004548 D-loop; other site 290338004549 H-loop/switch region; other site 290338004550 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 290338004551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338004552 Walker A/P-loop; other site 290338004553 ATP binding site [chemical binding]; other site 290338004554 Q-loop/lid; other site 290338004555 ABC transporter signature motif; other site 290338004556 Walker B; other site 290338004557 D-loop; other site 290338004558 H-loop/switch region; other site 290338004559 enolase; Provisional; Region: eno; PRK00077 290338004560 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290338004561 dimer interface [polypeptide binding]; other site 290338004562 metal binding site [ion binding]; metal-binding site 290338004563 substrate binding pocket [chemical binding]; other site 290338004564 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338004565 Ligand Binding Site [chemical binding]; other site 290338004566 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 290338004567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338004568 active site 290338004569 motif I; other site 290338004570 motif II; other site 290338004571 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290338004572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338004573 Coenzyme A binding pocket [chemical binding]; other site 290338004574 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290338004575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290338004576 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 290338004577 altronate oxidoreductase; Provisional; Region: PRK03643 290338004578 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290338004579 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290338004580 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 290338004581 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 290338004582 glutaminase; Provisional; Region: PRK00971 290338004583 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 290338004584 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290338004585 dimer interface [polypeptide binding]; other site 290338004586 ligand binding site [chemical binding]; other site 290338004587 HAMP domain; Region: HAMP; pfam00672 290338004588 dimerization interface [polypeptide binding]; other site 290338004589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338004590 dimer interface [polypeptide binding]; other site 290338004591 putative CheW interface [polypeptide binding]; other site 290338004592 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 290338004593 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 290338004594 NAD(P) binding site [chemical binding]; other site 290338004595 catalytic residues [active] 290338004596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338004597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338004598 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 290338004599 putative dimerization interface [polypeptide binding]; other site 290338004600 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 290338004601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290338004602 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 290338004603 NAD binding site [chemical binding]; other site 290338004604 dimer interface [polypeptide binding]; other site 290338004605 substrate binding site [chemical binding]; other site 290338004606 putative arabinose transporter; Provisional; Region: PRK03545 290338004607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004608 putative substrate translocation pore; other site 290338004609 inner membrane protein; Provisional; Region: PRK10995 290338004610 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 290338004611 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290338004612 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 290338004613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338004614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338004615 MarB protein; Region: MarB; pfam13999 290338004616 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 290338004617 EamA-like transporter family; Region: EamA; pfam00892 290338004618 EamA-like transporter family; Region: EamA; pfam00892 290338004619 putative transporter; Provisional; Region: PRK10054 290338004620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004621 putative substrate translocation pore; other site 290338004622 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 290338004623 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290338004624 Walker A/P-loop; other site 290338004625 ATP binding site [chemical binding]; other site 290338004626 Q-loop/lid; other site 290338004627 ABC transporter signature motif; other site 290338004628 Walker B; other site 290338004629 D-loop; other site 290338004630 H-loop/switch region; other site 290338004631 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 290338004632 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290338004633 Walker A/P-loop; other site 290338004634 ATP binding site [chemical binding]; other site 290338004635 Q-loop/lid; other site 290338004636 ABC transporter signature motif; other site 290338004637 Walker B; other site 290338004638 D-loop; other site 290338004639 H-loop/switch region; other site 290338004640 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 290338004641 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290338004642 TM-ABC transporter signature motif; other site 290338004643 HEAT repeats; Region: HEAT_2; pfam13646 290338004644 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290338004645 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338004646 TM-ABC transporter signature motif; other site 290338004647 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 290338004648 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 290338004649 putative ligand binding site [chemical binding]; other site 290338004650 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290338004651 substrate binding site [chemical binding]; other site 290338004652 THF binding site; other site 290338004653 zinc-binding site [ion binding]; other site 290338004654 diguanylate cyclase; Provisional; Region: PRK09894 290338004655 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 290338004656 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338004657 metal binding site [ion binding]; metal-binding site 290338004658 active site 290338004659 I-site; other site 290338004660 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290338004661 Beta-lactamase; Region: Beta-lactamase; pfam00144 290338004662 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 290338004663 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 290338004664 active site 290338004665 Zn binding site [ion binding]; other site 290338004666 malonic semialdehyde reductase; Provisional; Region: PRK10538 290338004667 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 290338004668 putative NAD(P) binding site [chemical binding]; other site 290338004669 homodimer interface [polypeptide binding]; other site 290338004670 homotetramer interface [polypeptide binding]; other site 290338004671 active site 290338004672 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290338004673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338004674 DNA-binding site [nucleotide binding]; DNA binding site 290338004675 FCD domain; Region: FCD; pfam07729 290338004676 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290338004677 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290338004678 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290338004679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004680 metabolite-proton symporter; Region: 2A0106; TIGR00883 290338004681 putative substrate translocation pore; other site 290338004682 putative oxidoreductase; Provisional; Region: PRK10083 290338004683 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 290338004684 putative NAD(P) binding site [chemical binding]; other site 290338004685 catalytic Zn binding site [ion binding]; other site 290338004686 structural Zn binding site [ion binding]; other site 290338004687 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 290338004688 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 290338004689 putative active site pocket [active] 290338004690 putative metal binding site [ion binding]; other site 290338004691 hypothetical protein; Provisional; Region: PRK02237 290338004692 hypothetical protein; Provisional; Region: PRK13659 290338004693 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 290338004694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338004695 Coenzyme A binding pocket [chemical binding]; other site 290338004696 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 290338004697 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 290338004698 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 290338004699 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 290338004700 putative [Fe4-S4] binding site [ion binding]; other site 290338004701 putative molybdopterin cofactor binding site [chemical binding]; other site 290338004702 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 290338004703 putative molybdopterin cofactor binding site; other site 290338004704 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 290338004705 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 290338004706 putative [Fe4-S4] binding site [ion binding]; other site 290338004707 putative molybdopterin cofactor binding site [chemical binding]; other site 290338004708 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 290338004709 putative molybdopterin cofactor binding site; other site 290338004710 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 290338004711 4Fe-4S binding domain; Region: Fer4; pfam00037 290338004712 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 290338004713 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 290338004714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004715 dimer interface [polypeptide binding]; other site 290338004716 conserved gate region; other site 290338004717 putative PBP binding loops; other site 290338004718 ABC-ATPase subunit interface; other site 290338004719 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 290338004720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004721 dimer interface [polypeptide binding]; other site 290338004722 conserved gate region; other site 290338004723 ABC-ATPase subunit interface; other site 290338004724 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290338004725 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290338004726 Walker A/P-loop; other site 290338004727 ATP binding site [chemical binding]; other site 290338004728 Q-loop/lid; other site 290338004729 ABC transporter signature motif; other site 290338004730 Walker B; other site 290338004731 D-loop; other site 290338004732 H-loop/switch region; other site 290338004733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 290338004734 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 290338004735 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 290338004736 Cl- selectivity filter; other site 290338004737 Cl- binding residues [ion binding]; other site 290338004738 pore gating glutamate residue; other site 290338004739 dimer interface [polypeptide binding]; other site 290338004740 putative dithiobiotin synthetase; Provisional; Region: PRK12374 290338004741 AAA domain; Region: AAA_26; pfam13500 290338004742 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290338004743 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290338004744 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338004745 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 290338004746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338004747 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 290338004748 dimerization interface [polypeptide binding]; other site 290338004749 substrate binding pocket [chemical binding]; other site 290338004750 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290338004751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004752 putative substrate translocation pore; other site 290338004753 CAAX protease self-immunity; Region: Abi; pfam02517 290338004754 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 290338004755 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 290338004756 active site 290338004757 Zn binding site [ion binding]; other site 290338004758 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 290338004759 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 290338004760 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 290338004761 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 290338004762 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290338004763 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 290338004764 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 290338004765 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 290338004766 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 290338004767 ligand binding site [chemical binding]; other site 290338004768 homodimer interface [polypeptide binding]; other site 290338004769 NAD(P) binding site [chemical binding]; other site 290338004770 trimer interface B [polypeptide binding]; other site 290338004771 trimer interface A [polypeptide binding]; other site 290338004772 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 290338004773 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338004774 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338004775 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338004776 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 290338004777 Spore germination protein; Region: Spore_permease; cl17796 290338004778 dihydromonapterin reductase; Provisional; Region: PRK06483 290338004779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338004780 NAD(P) binding site [chemical binding]; other site 290338004781 active site 290338004782 GlpM protein; Region: GlpM; pfam06942 290338004783 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 290338004784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338004785 active site 290338004786 phosphorylation site [posttranslational modification] 290338004787 intermolecular recognition site; other site 290338004788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338004789 DNA binding site [nucleotide binding] 290338004790 sensor protein RstB; Provisional; Region: PRK10604 290338004791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338004792 dimerization interface [polypeptide binding]; other site 290338004793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338004794 dimer interface [polypeptide binding]; other site 290338004795 phosphorylation site [posttranslational modification] 290338004796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338004797 ATP binding site [chemical binding]; other site 290338004798 Mg2+ binding site [ion binding]; other site 290338004799 G-X-G motif; other site 290338004800 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 290338004801 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290338004802 Class II fumarases; Region: Fumarase_classII; cd01362 290338004803 active site 290338004804 tetramer interface [polypeptide binding]; other site 290338004805 fumarate hydratase; Provisional; Region: PRK15389 290338004806 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 290338004807 Fumarase C-terminus; Region: Fumerase_C; pfam05683 290338004808 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 290338004809 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290338004810 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290338004811 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 290338004812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 290338004813 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 290338004814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338004815 DNA binding site [nucleotide binding] 290338004816 domain linker motif; other site 290338004817 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290338004818 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 290338004819 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 290338004820 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338004821 active site turn [active] 290338004822 phosphorylation site [posttranslational modification] 290338004823 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 290338004824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338004825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338004826 homodimer interface [polypeptide binding]; other site 290338004827 catalytic residue [active] 290338004828 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290338004829 adenosine deaminase; Provisional; Region: PRK09358 290338004830 active site 290338004831 putative oxidoreductase; Provisional; Region: PRK11579 290338004832 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338004833 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290338004834 Haemolysin expression modulating protein; Region: HHA; cl11501 290338004835 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 290338004836 electron transport complex protein RsxA; Provisional; Region: PRK05151 290338004837 electron transport complex protein RnfB; Provisional; Region: PRK05113 290338004838 Putative Fe-S cluster; Region: FeS; pfam04060 290338004839 4Fe-4S binding domain; Region: Fer4; pfam00037 290338004840 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 290338004841 SLBB domain; Region: SLBB; pfam10531 290338004842 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 290338004843 electron transport complex protein RnfG; Validated; Region: PRK01908 290338004844 electron transport complex RsxE subunit; Provisional; Region: PRK12405 290338004845 endonuclease III; Provisional; Region: PRK10702 290338004846 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290338004847 minor groove reading motif; other site 290338004848 helix-hairpin-helix signature motif; other site 290338004849 substrate binding pocket [chemical binding]; other site 290338004850 active site 290338004851 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 290338004852 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 290338004853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004854 putative substrate translocation pore; other site 290338004855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004856 glutathionine S-transferase; Provisional; Region: PRK10542 290338004857 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 290338004858 C-terminal domain interface [polypeptide binding]; other site 290338004859 GSH binding site (G-site) [chemical binding]; other site 290338004860 dimer interface [polypeptide binding]; other site 290338004861 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 290338004862 N-terminal domain interface [polypeptide binding]; other site 290338004863 dimer interface [polypeptide binding]; other site 290338004864 substrate binding pocket (H-site) [chemical binding]; other site 290338004865 pyridoxamine kinase; Validated; Region: PRK05756 290338004866 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 290338004867 dimer interface [polypeptide binding]; other site 290338004868 pyridoxal binding site [chemical binding]; other site 290338004869 ATP binding site [chemical binding]; other site 290338004870 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290338004871 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290338004872 active site 290338004873 HIGH motif; other site 290338004874 dimer interface [polypeptide binding]; other site 290338004875 KMSKS motif; other site 290338004876 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338004877 RNA binding surface [nucleotide binding]; other site 290338004878 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 290338004879 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290338004880 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 290338004881 lysozyme inhibitor; Provisional; Region: PRK11372 290338004882 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 290338004883 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 290338004884 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 290338004885 transcriptional regulator SlyA; Provisional; Region: PRK03573 290338004886 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 290338004887 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 290338004888 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 290338004889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338004890 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338004891 Fusaric acid resistance protein family; Region: FUSC; pfam04632 290338004892 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290338004893 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 290338004894 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 290338004895 E-class dimer interface [polypeptide binding]; other site 290338004896 P-class dimer interface [polypeptide binding]; other site 290338004897 active site 290338004898 Cu2+ binding site [ion binding]; other site 290338004899 Zn2+ binding site [ion binding]; other site 290338004900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338004901 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338004902 active site 290338004903 catalytic tetrad [active] 290338004904 Predicted Fe-S protein [General function prediction only]; Region: COG3313 290338004905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290338004906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338004907 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290338004908 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290338004909 FMN binding site [chemical binding]; other site 290338004910 active site 290338004911 substrate binding site [chemical binding]; other site 290338004912 catalytic residue [active] 290338004913 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 290338004914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290338004915 dimer interface [polypeptide binding]; other site 290338004916 active site 290338004917 glutathione binding site [chemical binding]; other site 290338004918 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 290338004919 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 290338004920 dimer interface [polypeptide binding]; other site 290338004921 catalytic site [active] 290338004922 putative active site [active] 290338004923 putative substrate binding site [chemical binding]; other site 290338004924 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 290338004925 putative GSH binding site [chemical binding]; other site 290338004926 catalytic residues [active] 290338004927 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290338004928 NlpC/P60 family; Region: NLPC_P60; pfam00877 290338004929 superoxide dismutase; Provisional; Region: PRK10543 290338004930 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290338004931 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290338004932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004933 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338004934 putative substrate translocation pore; other site 290338004935 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 290338004936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338004937 DNA binding site [nucleotide binding] 290338004938 domain linker motif; other site 290338004939 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 290338004940 dimerization interface [polypeptide binding]; other site 290338004941 ligand binding site [chemical binding]; other site 290338004942 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 290338004943 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338004944 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338004945 dimerization interface [polypeptide binding]; other site 290338004946 putative transporter; Provisional; Region: PRK11043 290338004947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338004948 putative substrate translocation pore; other site 290338004949 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 290338004950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338004951 S-adenosylmethionine binding site [chemical binding]; other site 290338004952 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 290338004953 Lumazine binding domain; Region: Lum_binding; pfam00677 290338004954 Lumazine binding domain; Region: Lum_binding; pfam00677 290338004955 multidrug efflux protein; Reviewed; Region: PRK01766 290338004956 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 290338004957 cation binding site [ion binding]; other site 290338004958 outer membrane receptor FepA; Provisional; Region: PRK13524 290338004959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338004960 N-terminal plug; other site 290338004961 ligand-binding site [chemical binding]; other site 290338004962 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290338004963 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290338004964 putative catalytic site [active] 290338004965 putative phosphate binding site [ion binding]; other site 290338004966 putative metal binding site [ion binding]; other site 290338004967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290338004968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338004969 substrate binding pocket [chemical binding]; other site 290338004970 membrane-bound complex binding site; other site 290338004971 hinge residues; other site 290338004972 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290338004973 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290338004974 Walker A/P-loop; other site 290338004975 ATP binding site [chemical binding]; other site 290338004976 Q-loop/lid; other site 290338004977 ABC transporter signature motif; other site 290338004978 Walker B; other site 290338004979 D-loop; other site 290338004980 H-loop/switch region; other site 290338004981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004982 dimer interface [polypeptide binding]; other site 290338004983 conserved gate region; other site 290338004984 putative PBP binding loops; other site 290338004985 ABC-ATPase subunit interface; other site 290338004986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338004987 dimer interface [polypeptide binding]; other site 290338004988 conserved gate region; other site 290338004989 putative PBP binding loops; other site 290338004990 ABC-ATPase subunit interface; other site 290338004991 hypothetical protein; Provisional; Region: PRK09946 290338004992 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 290338004993 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 290338004994 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 290338004995 4Fe-4S binding domain; Region: Fer4; cl02805 290338004996 hypothetical protein; Provisional; Region: PRK09947 290338004997 putative oxidoreductase; Provisional; Region: PRK09849 290338004998 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 290338004999 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 290338005000 hypothetical protein; Provisional; Region: PRK09898 290338005001 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338005002 hypothetical protein; Provisional; Region: PRK10292 290338005003 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 290338005004 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 290338005005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005006 dimer interface [polypeptide binding]; other site 290338005007 conserved gate region; other site 290338005008 putative PBP binding loops; other site 290338005009 ABC-ATPase subunit interface; other site 290338005010 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290338005011 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290338005012 Walker A/P-loop; other site 290338005013 ATP binding site [chemical binding]; other site 290338005014 Q-loop/lid; other site 290338005015 ABC transporter signature motif; other site 290338005016 Walker B; other site 290338005017 D-loop; other site 290338005018 H-loop/switch region; other site 290338005019 NIL domain; Region: NIL; pfam09383 290338005020 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290338005021 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290338005022 dimer interface [polypeptide binding]; other site 290338005023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338005024 catalytic residue [active] 290338005025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290338005026 FOG: CBS domain [General function prediction only]; Region: COG0517 290338005027 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 290338005028 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290338005029 homodimer interface [polypeptide binding]; other site 290338005030 substrate-cofactor binding pocket; other site 290338005031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338005032 catalytic residue [active] 290338005033 pyruvate kinase; Provisional; Region: PRK09206 290338005034 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 290338005035 domain interfaces; other site 290338005036 active site 290338005037 murein lipoprotein; Provisional; Region: PRK15396 290338005038 L,D-transpeptidase; Provisional; Region: PRK10190 290338005039 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338005040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338005041 cysteine desufuration protein SufE; Provisional; Region: PRK09296 290338005042 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290338005043 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290338005044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338005045 catalytic residue [active] 290338005046 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 290338005047 FeS assembly protein SufD; Region: sufD; TIGR01981 290338005048 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 290338005049 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 290338005050 Walker A/P-loop; other site 290338005051 ATP binding site [chemical binding]; other site 290338005052 Q-loop/lid; other site 290338005053 ABC transporter signature motif; other site 290338005054 Walker B; other site 290338005055 D-loop; other site 290338005056 H-loop/switch region; other site 290338005057 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 290338005058 putative ABC transporter; Region: ycf24; CHL00085 290338005059 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 290338005060 transcriptional regulator; Provisional; Region: PRK10632 290338005061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338005062 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290338005063 putative effector binding pocket; other site 290338005064 dimerization interface [polypeptide binding]; other site 290338005065 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290338005066 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290338005067 CoenzymeA binding site [chemical binding]; other site 290338005068 subunit interaction site [polypeptide binding]; other site 290338005069 PHB binding site; other site 290338005070 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290338005071 FAD binding domain; Region: FAD_binding_4; pfam01565 290338005072 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290338005073 putative inner membrane protein; Provisional; Region: PRK10983 290338005074 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290338005075 phosphoenolpyruvate synthase; Validated; Region: PRK06464 290338005076 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290338005077 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290338005078 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290338005079 PEP synthetase regulatory protein; Provisional; Region: PRK05339 290338005080 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 290338005081 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290338005082 hypothetical protein; Provisional; Region: PRK10183 290338005083 Uncharacterized conserved protein [Function unknown]; Region: COG0397 290338005084 hypothetical protein; Validated; Region: PRK00029 290338005085 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 290338005086 NlpC/P60 family; Region: NLPC_P60; pfam00877 290338005087 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 290338005088 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338005089 Walker A/P-loop; other site 290338005090 ATP binding site [chemical binding]; other site 290338005091 Q-loop/lid; other site 290338005092 ABC transporter signature motif; other site 290338005093 Walker B; other site 290338005094 D-loop; other site 290338005095 H-loop/switch region; other site 290338005096 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 290338005097 catalytic residues [active] 290338005098 dimer interface [polypeptide binding]; other site 290338005099 beta-lactamase TEM; Provisional; Region: PRK15442 290338005100 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 290338005101 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338005102 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338005103 ABC-ATPase subunit interface; other site 290338005104 dimer interface [polypeptide binding]; other site 290338005105 putative PBP binding regions; other site 290338005106 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290338005107 IHF dimer interface [polypeptide binding]; other site 290338005108 IHF - DNA interface [nucleotide binding]; other site 290338005109 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290338005110 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290338005111 putative tRNA-binding site [nucleotide binding]; other site 290338005112 B3/4 domain; Region: B3_4; pfam03483 290338005113 tRNA synthetase B5 domain; Region: B5; smart00874 290338005114 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290338005115 dimer interface [polypeptide binding]; other site 290338005116 motif 1; other site 290338005117 motif 3; other site 290338005118 motif 2; other site 290338005119 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 290338005120 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290338005121 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290338005122 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290338005123 dimer interface [polypeptide binding]; other site 290338005124 motif 1; other site 290338005125 active site 290338005126 motif 2; other site 290338005127 motif 3; other site 290338005128 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290338005129 23S rRNA binding site [nucleotide binding]; other site 290338005130 L21 binding site [polypeptide binding]; other site 290338005131 L13 binding site [polypeptide binding]; other site 290338005132 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 290338005133 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290338005134 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290338005135 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 290338005136 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 290338005137 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 290338005138 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290338005139 active site 290338005140 dimer interface [polypeptide binding]; other site 290338005141 motif 1; other site 290338005142 motif 2; other site 290338005143 motif 3; other site 290338005144 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290338005145 anticodon binding site; other site 290338005146 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 290338005147 6-phosphofructokinase 2; Provisional; Region: PRK10294 290338005148 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290338005149 putative substrate binding site [chemical binding]; other site 290338005150 putative ATP binding site [chemical binding]; other site 290338005151 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 290338005152 Phosphotransferase enzyme family; Region: APH; pfam01636 290338005153 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 290338005154 active site 290338005155 ATP binding site [chemical binding]; other site 290338005156 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290338005157 YniB-like protein; Region: YniB; pfam14002 290338005158 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 290338005159 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290338005160 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338005161 motif II; other site 290338005162 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 290338005163 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290338005164 NADP binding site [chemical binding]; other site 290338005165 homodimer interface [polypeptide binding]; other site 290338005166 active site 290338005167 inner membrane protein; Provisional; Region: PRK11648 290338005168 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 290338005169 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338005170 cell division modulator; Provisional; Region: PRK10113 290338005171 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 290338005172 putative active site [active] 290338005173 YdjC motif; other site 290338005174 Mg binding site [ion binding]; other site 290338005175 putative homodimer interface [polypeptide binding]; other site 290338005176 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290338005177 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 290338005178 NAD binding site [chemical binding]; other site 290338005179 sugar binding site [chemical binding]; other site 290338005180 divalent metal binding site [ion binding]; other site 290338005181 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290338005182 dimer interface [polypeptide binding]; other site 290338005183 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 290338005184 Cupin domain; Region: Cupin_2; pfam07883 290338005185 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338005186 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 290338005187 methionine cluster; other site 290338005188 active site 290338005189 phosphorylation site [posttranslational modification] 290338005190 metal binding site [ion binding]; metal-binding site 290338005191 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 290338005192 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290338005193 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 290338005194 active site 290338005195 P-loop; other site 290338005196 phosphorylation site [posttranslational modification] 290338005197 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 290338005198 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 290338005199 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290338005200 homodimer interface [polypeptide binding]; other site 290338005201 NAD binding pocket [chemical binding]; other site 290338005202 ATP binding pocket [chemical binding]; other site 290338005203 Mg binding site [ion binding]; other site 290338005204 active-site loop [active] 290338005205 hypothetical protein; Provisional; Region: PRK11396 290338005206 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 290338005207 dimer interface [polypeptide binding]; other site 290338005208 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 290338005209 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 290338005210 putative active site [active] 290338005211 Zn binding site [ion binding]; other site 290338005212 succinylarginine dihydrolase; Provisional; Region: PRK13281 290338005213 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 290338005214 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 290338005215 NAD(P) binding site [chemical binding]; other site 290338005216 catalytic residues [active] 290338005217 arginine succinyltransferase; Provisional; Region: PRK10456 290338005218 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 290338005219 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 290338005220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338005221 inhibitor-cofactor binding pocket; inhibition site 290338005222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338005223 catalytic residue [active] 290338005224 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 290338005225 putative catalytic site [active] 290338005226 putative phosphate binding site [ion binding]; other site 290338005227 active site 290338005228 metal binding site A [ion binding]; metal-binding site 290338005229 DNA binding site [nucleotide binding] 290338005230 putative AP binding site [nucleotide binding]; other site 290338005231 putative metal binding site B [ion binding]; other site 290338005232 Uncharacterized conserved protein [Function unknown]; Region: COG0398 290338005233 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290338005234 hypothetical protein; Provisional; Region: PRK11622 290338005235 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 290338005236 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 290338005237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005238 ABC-ATPase subunit interface; other site 290338005239 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 290338005240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338005241 Walker A/P-loop; other site 290338005242 ATP binding site [chemical binding]; other site 290338005243 Q-loop/lid; other site 290338005244 ABC transporter signature motif; other site 290338005245 Walker B; other site 290338005246 D-loop; other site 290338005247 H-loop/switch region; other site 290338005248 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290338005249 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290338005250 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290338005251 active site residue [active] 290338005252 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290338005253 active site residue [active] 290338005254 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290338005255 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290338005256 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290338005257 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290338005258 active site 290338005259 8-oxo-dGMP binding site [chemical binding]; other site 290338005260 nudix motif; other site 290338005261 metal binding site [ion binding]; metal-binding site 290338005262 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 290338005263 glutamate dehydrogenase; Provisional; Region: PRK09414 290338005264 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 290338005265 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 290338005266 NAD(P) binding site [chemical binding]; other site 290338005267 DNA topoisomerase III; Provisional; Region: PRK07726 290338005268 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 290338005269 active site 290338005270 putative interdomain interaction site [polypeptide binding]; other site 290338005271 putative metal-binding site [ion binding]; other site 290338005272 putative nucleotide binding site [chemical binding]; other site 290338005273 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290338005274 domain I; other site 290338005275 DNA binding groove [nucleotide binding] 290338005276 phosphate binding site [ion binding]; other site 290338005277 domain II; other site 290338005278 domain III; other site 290338005279 nucleotide binding site [chemical binding]; other site 290338005280 catalytic site [active] 290338005281 domain IV; other site 290338005282 selenophosphate synthetase; Provisional; Region: PRK00943 290338005283 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 290338005284 dimerization interface [polypeptide binding]; other site 290338005285 putative ATP binding site [chemical binding]; other site 290338005286 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 290338005287 putative FMN binding site [chemical binding]; other site 290338005288 protease 4; Provisional; Region: PRK10949 290338005289 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 290338005290 tandem repeat interface [polypeptide binding]; other site 290338005291 oligomer interface [polypeptide binding]; other site 290338005292 active site residues [active] 290338005293 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 290338005294 tandem repeat interface [polypeptide binding]; other site 290338005295 oligomer interface [polypeptide binding]; other site 290338005296 active site residues [active] 290338005297 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 290338005298 active site 290338005299 homodimer interface [polypeptide binding]; other site 290338005300 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 290338005301 Isochorismatase family; Region: Isochorismatase; pfam00857 290338005302 catalytic triad [active] 290338005303 metal binding site [ion binding]; metal-binding site 290338005304 conserved cis-peptide bond; other site 290338005305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 290338005306 methionine sulfoxide reductase B; Provisional; Region: PRK00222 290338005307 SelR domain; Region: SelR; pfam01641 290338005308 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 290338005309 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 290338005310 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290338005311 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 290338005312 active site 290338005313 phosphate binding residues; other site 290338005314 catalytic residues [active] 290338005315 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 290338005316 flagellar assembly protein J; Reviewed; Region: PRK06041 290338005317 PrkA family serine protein kinase; Provisional; Region: PRK15455 290338005318 AAA ATPase domain; Region: AAA_16; pfam13191 290338005319 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 290338005320 hypothetical protein; Provisional; Region: PRK05325 290338005321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338005322 S-adenosylmethionine binding site [chemical binding]; other site 290338005323 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 290338005324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338005325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338005326 metal binding site [ion binding]; metal-binding site 290338005327 active site 290338005328 I-site; other site 290338005329 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 290338005330 putative deacylase active site [active] 290338005331 Predicted membrane protein [Function unknown]; Region: COG2707 290338005332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338005333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338005334 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290338005335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338005336 hypothetical protein; Validated; Region: PRK06186 290338005337 conserved cys residue [active] 290338005338 Uncharacterized conserved protein [Function unknown]; Region: COG3189 290338005339 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 290338005340 Domain of unknown function (DUF333); Region: DUF333; pfam03891 290338005341 hypothetical protein; Provisional; Region: PRK10457 290338005342 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 290338005343 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 290338005344 [4Fe-4S] binding site [ion binding]; other site 290338005345 molybdopterin cofactor binding site; other site 290338005346 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 290338005347 molybdopterin cofactor binding site; other site 290338005348 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 290338005349 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 290338005350 leucine export protein LeuE; Provisional; Region: PRK10958 290338005351 zinc/cadmium-binding protein; Provisional; Region: PRK10306 290338005352 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 290338005353 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 290338005354 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 290338005355 molybdopterin cofactor binding site [chemical binding]; other site 290338005356 substrate binding site [chemical binding]; other site 290338005357 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 290338005358 molybdopterin cofactor binding site; other site 290338005359 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 290338005360 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 290338005361 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338005362 Ligand Binding Site [chemical binding]; other site 290338005363 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290338005364 putative acyl-acceptor binding pocket; other site 290338005365 isocitrate dehydrogenase; Validated; Region: PRK07362 290338005366 isocitrate dehydrogenase; Reviewed; Region: PRK07006 290338005367 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 290338005368 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 290338005369 probable active site [active] 290338005370 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 290338005371 nudix motif; other site 290338005372 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290338005373 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 290338005374 putative lysogenization regulator; Reviewed; Region: PRK00218 290338005375 adenylosuccinate lyase; Provisional; Region: PRK09285 290338005376 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 290338005377 tetramer interface [polypeptide binding]; other site 290338005378 active site 290338005379 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290338005380 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290338005381 active site 290338005382 DNA binding site [nucleotide binding] 290338005383 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290338005384 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 290338005385 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290338005386 Catalytic site [active] 290338005387 Predicted membrane protein [Function unknown]; Region: COG2246 290338005388 GtrA-like protein; Region: GtrA; pfam04138 290338005389 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 290338005390 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290338005391 Ligand binding site; other site 290338005392 Putative Catalytic site; other site 290338005393 DXD motif; other site 290338005394 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 290338005395 homoaconitase; Region: h_aconitase; TIGR00139 290338005396 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 290338005397 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 290338005398 Phage-related minor tail protein [Function unknown]; Region: COG5281 290338005399 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 290338005400 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 290338005401 Bacterial Ig-like domain 2; Region: BID_2; smart00635 290338005402 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 290338005403 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 290338005404 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 290338005405 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 290338005406 Phage terminase large subunit; Region: Terminase_3; cl12054 290338005407 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 290338005408 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 290338005409 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 290338005410 catalytic residues [active] 290338005411 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 290338005412 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 290338005413 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 290338005414 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 290338005415 DinI-like family; Region: DinI; cl11630 290338005416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338005417 S-adenosylmethionine binding site [chemical binding]; other site 290338005418 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290338005419 Ligand Binding Site [chemical binding]; other site 290338005420 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290338005421 Active Sites [active] 290338005422 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 290338005423 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 290338005424 Replication protein P; Region: Phage_lambda_P; pfam06992 290338005425 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 290338005426 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 290338005427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338005428 transcriptional repressor DicA; Reviewed; Region: PRK09706 290338005429 sequence-specific DNA binding site [nucleotide binding]; other site 290338005430 salt bridge; other site 290338005431 Protein of unknown function (DUF2767); Region: DUF2767; pfam10965 290338005432 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 290338005433 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 290338005434 exonuclease VIII; Reviewed; Region: PRK09709 290338005435 RecT family; Region: RecT; pfam03837 290338005436 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 290338005437 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 290338005438 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 290338005439 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 290338005440 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290338005441 active site 290338005442 DNA binding site [nucleotide binding] 290338005443 Int/Topo IB signature motif; other site 290338005444 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 290338005445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338005446 active site 290338005447 phosphorylation site [posttranslational modification] 290338005448 intermolecular recognition site; other site 290338005449 dimerization interface [polypeptide binding]; other site 290338005450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338005451 DNA binding site [nucleotide binding] 290338005452 sensor protein PhoQ; Provisional; Region: PRK10815 290338005453 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 290338005454 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 290338005455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338005456 ATP binding site [chemical binding]; other site 290338005457 Mg2+ binding site [ion binding]; other site 290338005458 G-X-G motif; other site 290338005459 Uncharacterized conserved protein [Function unknown]; Region: COG2850 290338005460 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 290338005461 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 290338005462 metal binding site [ion binding]; metal-binding site 290338005463 dimer interface [polypeptide binding]; other site 290338005464 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 290338005465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338005466 Walker A/P-loop; other site 290338005467 ATP binding site [chemical binding]; other site 290338005468 Q-loop/lid; other site 290338005469 ABC transporter signature motif; other site 290338005470 Walker B; other site 290338005471 D-loop; other site 290338005472 H-loop/switch region; other site 290338005473 TOBE domain; Region: TOBE_2; pfam08402 290338005474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005475 dimer interface [polypeptide binding]; other site 290338005476 conserved gate region; other site 290338005477 putative PBP binding loops; other site 290338005478 ABC-ATPase subunit interface; other site 290338005479 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290338005480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005481 dimer interface [polypeptide binding]; other site 290338005482 conserved gate region; other site 290338005483 putative PBP binding loops; other site 290338005484 ABC-ATPase subunit interface; other site 290338005485 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 290338005486 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 290338005487 NAD-dependent deacetylase; Provisional; Region: PRK00481 290338005488 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 290338005489 NAD+ binding site [chemical binding]; other site 290338005490 substrate binding site [chemical binding]; other site 290338005491 Zn binding site [ion binding]; other site 290338005492 fructokinase; Reviewed; Region: PRK09557 290338005493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338005494 nucleotide binding site [chemical binding]; other site 290338005495 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 290338005496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290338005497 FtsX-like permease family; Region: FtsX; pfam02687 290338005498 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 290338005499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290338005500 Walker A/P-loop; other site 290338005501 ATP binding site [chemical binding]; other site 290338005502 Q-loop/lid; other site 290338005503 ABC transporter signature motif; other site 290338005504 Walker B; other site 290338005505 D-loop; other site 290338005506 H-loop/switch region; other site 290338005507 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 290338005508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290338005509 FtsX-like permease family; Region: FtsX; pfam02687 290338005510 Predicted membrane protein [Function unknown]; Region: COG4763 290338005511 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290338005512 transcription-repair coupling factor; Provisional; Region: PRK10689 290338005513 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 290338005514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338005515 ATP binding site [chemical binding]; other site 290338005516 putative Mg++ binding site [ion binding]; other site 290338005517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338005518 nucleotide binding region [chemical binding]; other site 290338005519 ATP-binding site [chemical binding]; other site 290338005520 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 290338005521 L,D-transpeptidase; Provisional; Region: PRK10190 290338005522 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338005523 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338005524 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338005525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290338005526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338005527 hypothetical protein; Provisional; Region: PRK11280 290338005528 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290338005529 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338005530 hypothetical protein; Provisional; Region: PRK04940 290338005531 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290338005532 beta-hexosaminidase; Provisional; Region: PRK05337 290338005533 thiamine kinase; Provisional; Region: thiK; PRK10271 290338005534 substrate binding site [chemical binding]; other site 290338005535 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 290338005536 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 290338005537 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 290338005538 putative dimer interface [polypeptide binding]; other site 290338005539 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 290338005540 nucleotide binding site/active site [active] 290338005541 HIT family signature motif; other site 290338005542 catalytic residue [active] 290338005543 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 290338005544 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338005545 N-terminal plug; other site 290338005546 ligand-binding site [chemical binding]; other site 290338005547 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 290338005548 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290338005549 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338005550 active site turn [active] 290338005551 phosphorylation site [posttranslational modification] 290338005552 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290338005553 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 290338005554 active site 290338005555 DNA polymerase III subunit delta'; Validated; Region: PRK07993 290338005556 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 290338005557 thymidylate kinase; Validated; Region: tmk; PRK00698 290338005558 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290338005559 TMP-binding site; other site 290338005560 ATP-binding site [chemical binding]; other site 290338005561 conserved hypothetical protein, YceG family; Region: TIGR00247 290338005562 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 290338005563 dimerization interface [polypeptide binding]; other site 290338005564 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290338005565 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 290338005566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338005567 catalytic residue [active] 290338005568 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 290338005569 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290338005570 dimer interface [polypeptide binding]; other site 290338005571 active site 290338005572 acyl carrier protein; Provisional; Region: acpP; PRK00982 290338005573 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290338005574 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 290338005575 NAD(P) binding site [chemical binding]; other site 290338005576 homotetramer interface [polypeptide binding]; other site 290338005577 homodimer interface [polypeptide binding]; other site 290338005578 active site 290338005579 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 290338005580 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338005581 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290338005582 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290338005583 dimer interface [polypeptide binding]; other site 290338005584 active site 290338005585 CoA binding pocket [chemical binding]; other site 290338005586 putative phosphate acyltransferase; Provisional; Region: PRK05331 290338005587 hypothetical protein; Provisional; Region: PRK11193 290338005588 Maf-like protein; Region: Maf; pfam02545 290338005589 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290338005590 active site 290338005591 dimer interface [polypeptide binding]; other site 290338005592 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 290338005593 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338005594 RNA binding surface [nucleotide binding]; other site 290338005595 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290338005596 active site 290338005597 RNase E 5' utr element 290338005598 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 290338005599 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290338005600 homodimer interface [polypeptide binding]; other site 290338005601 oligonucleotide binding site [chemical binding]; other site 290338005602 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 290338005603 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 290338005604 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290338005605 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 290338005606 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338005607 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 290338005608 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 290338005609 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 290338005610 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 290338005611 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 290338005612 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 290338005613 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 290338005614 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 290338005615 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 290338005616 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338005617 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290338005618 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 290338005619 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338005620 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 290338005621 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 290338005622 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338005623 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 290338005624 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290338005625 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 290338005626 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 290338005627 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 290338005628 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 290338005629 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338005630 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290338005631 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 290338005632 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 290338005633 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 290338005634 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290338005635 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 290338005636 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 290338005637 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 290338005638 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 290338005639 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 290338005640 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290338005641 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338005642 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290338005643 hypothetical protein; Provisional; Region: PRK11239 290338005644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 290338005645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290338005646 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290338005647 multidrug resistance protein MdtH; Provisional; Region: PRK11646 290338005648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338005649 putative substrate translocation pore; other site 290338005650 glutaredoxin 2; Provisional; Region: PRK10387 290338005651 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290338005652 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 290338005653 N-terminal domain interface [polypeptide binding]; other site 290338005654 lipoprotein; Provisional; Region: PRK10598 290338005655 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 290338005656 active site 290338005657 substrate binding pocket [chemical binding]; other site 290338005658 dimer interface [polypeptide binding]; other site 290338005659 DNA damage-inducible protein I; Provisional; Region: PRK10597 290338005660 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 290338005661 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 290338005662 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290338005663 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 290338005664 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 290338005665 hypothetical protein; Provisional; Region: PRK03757 290338005666 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 290338005667 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 290338005668 active site residue [active] 290338005669 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 290338005670 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290338005671 putative acyl-acceptor binding pocket; other site 290338005672 drug efflux system protein MdtG; Provisional; Region: PRK09874 290338005673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338005674 putative substrate translocation pore; other site 290338005675 secY/secA suppressor protein; Provisional; Region: PRK11467 290338005676 lipoprotein; Provisional; Region: PRK10175 290338005677 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290338005678 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 290338005679 Ligand binding site; other site 290338005680 DXD motif; other site 290338005681 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 290338005682 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 290338005683 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 290338005684 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290338005685 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 290338005686 PLD-like domain; Region: PLDc_2; pfam13091 290338005687 putative active site [active] 290338005688 catalytic site [active] 290338005689 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 290338005690 PLD-like domain; Region: PLDc_2; pfam13091 290338005691 putative active site [active] 290338005692 catalytic site [active] 290338005693 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 290338005694 putative ADP-ribose binding site [chemical binding]; other site 290338005695 putative active site [active] 290338005696 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338005697 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 290338005698 major curlin subunit; Provisional; Region: csgA; PRK10051 290338005699 Curlin associated repeat; Region: Curlin_rpt; pfam07012 290338005700 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 290338005701 Curlin associated repeat; Region: Curlin_rpt; pfam07012 290338005702 Curlin associated repeat; Region: Curlin_rpt; pfam07012 290338005703 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 290338005704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338005705 DNA binding residues [nucleotide binding] 290338005706 dimerization interface [polypeptide binding]; other site 290338005707 curli assembly protein CsgE; Provisional; Region: PRK10386 290338005708 curli assembly protein CsgF; Provisional; Region: PRK10050 290338005709 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 290338005710 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 290338005711 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 290338005712 putative hydrolase; Validated; Region: PRK09248 290338005713 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 290338005714 active site 290338005715 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 290338005716 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 290338005717 putative ligand binding site [chemical binding]; other site 290338005718 NAD binding site [chemical binding]; other site 290338005719 dimerization interface [polypeptide binding]; other site 290338005720 catalytic site [active] 290338005721 hypothetical protein; Provisional; Region: PRK10536 290338005722 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290338005723 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 290338005724 Na binding site [ion binding]; other site 290338005725 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 290338005726 Predicted transcriptional regulator [Transcription]; Region: COG3905 290338005727 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 290338005728 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 290338005729 Glutamate binding site [chemical binding]; other site 290338005730 NAD binding site [chemical binding]; other site 290338005731 catalytic residues [active] 290338005732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 290338005733 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 290338005734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338005735 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 290338005736 General stress protein [General function prediction only]; Region: GsiB; COG3729 290338005737 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 290338005738 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290338005739 hypothetical protein; Provisional; Region: PRK10174 290338005740 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 290338005741 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 290338005742 catalytic core [active] 290338005743 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 290338005744 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290338005745 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290338005746 catalytic residues [active] 290338005747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290338005748 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290338005749 Walker A/P-loop; other site 290338005750 ATP binding site [chemical binding]; other site 290338005751 Q-loop/lid; other site 290338005752 ABC transporter signature motif; other site 290338005753 Walker B; other site 290338005754 D-loop; other site 290338005755 H-loop/switch region; other site 290338005756 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290338005757 FtsX-like permease family; Region: FtsX; pfam02687 290338005758 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290338005759 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290338005760 FtsX-like permease family; Region: FtsX; pfam02687 290338005761 Predicted membrane protein [Function unknown]; Region: COG4393 290338005762 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 290338005763 Uncharacterized conserved protein [Function unknown]; Region: COG3350 290338005764 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 290338005765 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 290338005766 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 290338005767 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 290338005768 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 290338005769 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290338005770 catalytic residues [active] 290338005771 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 290338005772 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290338005773 catalytic residues [active] 290338005774 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 290338005775 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290338005776 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290338005777 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 290338005778 DsbD alpha interface [polypeptide binding]; other site 290338005779 catalytic residues [active] 290338005780 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 290338005781 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290338005782 HSP70 interaction site [polypeptide binding]; other site 290338005783 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290338005784 substrate binding site [polypeptide binding]; other site 290338005785 dimer interface [polypeptide binding]; other site 290338005786 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 290338005787 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 290338005788 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 290338005789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338005790 non-specific DNA binding site [nucleotide binding]; other site 290338005791 salt bridge; other site 290338005792 sequence-specific DNA binding site [nucleotide binding]; other site 290338005793 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 290338005794 4Fe-4S binding domain; Region: Fer4_5; pfam12801 290338005795 4Fe-4S binding domain; Region: Fer4_5; pfam12801 290338005796 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 290338005797 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338005798 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 290338005799 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290338005800 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290338005801 Walker A/P-loop; other site 290338005802 ATP binding site [chemical binding]; other site 290338005803 Q-loop/lid; other site 290338005804 ABC transporter signature motif; other site 290338005805 Walker B; other site 290338005806 D-loop; other site 290338005807 H-loop/switch region; other site 290338005808 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290338005809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005810 dimer interface [polypeptide binding]; other site 290338005811 conserved gate region; other site 290338005812 putative PBP binding loops; other site 290338005813 ABC-ATPase subunit interface; other site 290338005814 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 290338005815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338005816 substrate binding pocket [chemical binding]; other site 290338005817 membrane-bound complex binding site; other site 290338005818 aspartate racemase; Region: asp_race; TIGR00035 290338005819 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290338005820 D-cysteine desulfhydrase; Validated; Region: PRK03910 290338005821 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290338005822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338005823 catalytic residue [active] 290338005824 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 290338005825 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 290338005826 NMT1-like family; Region: NMT1_2; pfam13379 290338005827 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290338005828 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290338005829 Walker A/P-loop; other site 290338005830 ATP binding site [chemical binding]; other site 290338005831 Q-loop/lid; other site 290338005832 ABC transporter signature motif; other site 290338005833 Walker B; other site 290338005834 D-loop; other site 290338005835 H-loop/switch region; other site 290338005836 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290338005837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005838 putative PBP binding loops; other site 290338005839 dimer interface [polypeptide binding]; other site 290338005840 ABC-ATPase subunit interface; other site 290338005841 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290338005842 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; pfam10707 290338005843 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 290338005844 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338005845 N-terminal plug; other site 290338005846 ligand-binding site [chemical binding]; other site 290338005847 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290338005848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338005849 active site 290338005850 phosphorylation site [posttranslational modification] 290338005851 intermolecular recognition site; other site 290338005852 dimerization interface [polypeptide binding]; other site 290338005853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290338005854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290338005855 Walker A motif; other site 290338005856 ATP binding site [chemical binding]; other site 290338005857 Walker B motif; other site 290338005858 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338005859 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 290338005860 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 290338005861 dimerization interface [polypeptide binding]; other site 290338005862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338005863 dimer interface [polypeptide binding]; other site 290338005864 phosphorylation site [posttranslational modification] 290338005865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338005866 ATP binding site [chemical binding]; other site 290338005867 Mg2+ binding site [ion binding]; other site 290338005868 G-X-G motif; other site 290338005869 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 290338005870 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290338005871 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 290338005872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338005873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338005874 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 290338005875 YccA-like proteins; Region: YccA_like; cd10433 290338005876 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 290338005877 sulfur transfer protein TusE; Provisional; Region: PRK11508 290338005878 acylphosphatase; Provisional; Region: PRK14426 290338005879 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 290338005880 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 290338005881 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 290338005882 putative RNA binding site [nucleotide binding]; other site 290338005883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338005884 S-adenosylmethionine binding site [chemical binding]; other site 290338005885 heat shock protein HspQ; Provisional; Region: PRK14129 290338005886 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 290338005887 hypothetical protein; Provisional; Region: PRK03641 290338005888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 290338005889 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 290338005890 active site 290338005891 dimer interfaces [polypeptide binding]; other site 290338005892 catalytic residues [active] 290338005893 DNA helicase IV; Provisional; Region: helD; PRK11054 290338005894 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 290338005895 Part of AAA domain; Region: AAA_19; pfam13245 290338005896 Family description; Region: UvrD_C_2; pfam13538 290338005897 hypothetical protein; Provisional; Region: PRK11770 290338005898 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290338005899 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290338005900 TIGR01666 family membrane protein; Region: YCCS 290338005901 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 290338005902 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290338005903 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 290338005904 TfoX C-terminal domain; Region: TfoX_C; pfam04994 290338005905 cell division inhibitor SulA; Region: sula; TIGR00623 290338005906 outer membrane protein A; Reviewed; Region: PRK10808 290338005907 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 290338005908 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290338005909 ligand binding site [chemical binding]; other site 290338005910 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 290338005911 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 290338005912 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290338005913 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 290338005914 active site 1 [active] 290338005915 dimer interface [polypeptide binding]; other site 290338005916 active site 2 [active] 290338005917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 290338005918 Protein of unknown function (DUF330); Region: DUF330; pfam03886 290338005919 paraquat-inducible protein B; Provisional; Region: PRK10807 290338005920 mce related protein; Region: MCE; pfam02470 290338005921 mce related protein; Region: MCE; pfam02470 290338005922 mce related protein; Region: MCE; pfam02470 290338005923 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 290338005924 Paraquat-inducible protein A; Region: PqiA; pfam04403 290338005925 Paraquat-inducible protein A; Region: PqiA; pfam04403 290338005926 ABC transporter ATPase component; Reviewed; Region: PRK11147 290338005927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338005928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338005929 Walker A/P-loop; other site 290338005930 Walker A/P-loop; other site 290338005931 ATP binding site [chemical binding]; other site 290338005932 ATP binding site [chemical binding]; other site 290338005933 Q-loop/lid; other site 290338005934 Q-loop/lid; other site 290338005935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338005936 ABC transporter signature motif; other site 290338005937 Walker B; other site 290338005938 D-loop; other site 290338005939 ABC transporter; Region: ABC_tran_2; pfam12848 290338005940 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338005941 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 290338005942 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 290338005943 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 290338005944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338005945 S-adenosylmethionine binding site [chemical binding]; other site 290338005946 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 290338005947 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 290338005948 MOSC domain; Region: MOSC; pfam03473 290338005949 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290338005950 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290338005951 catalytic loop [active] 290338005952 iron binding site [ion binding]; other site 290338005953 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 290338005954 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 290338005955 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 290338005956 quinone interaction residues [chemical binding]; other site 290338005957 active site 290338005958 catalytic residues [active] 290338005959 FMN binding site [chemical binding]; other site 290338005960 substrate binding site [chemical binding]; other site 290338005961 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 290338005962 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290338005963 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 290338005964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338005965 substrate binding pocket [chemical binding]; other site 290338005966 membrane-bound complex binding site; other site 290338005967 hinge residues; other site 290338005968 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 290338005969 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 290338005970 active site 290338005971 dimer interface [polypeptide binding]; other site 290338005972 non-prolyl cis peptide bond; other site 290338005973 insertion regions; other site 290338005974 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290338005975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338005976 dimer interface [polypeptide binding]; other site 290338005977 conserved gate region; other site 290338005978 putative PBP binding loops; other site 290338005979 ABC-ATPase subunit interface; other site 290338005980 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 290338005981 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290338005982 Walker A/P-loop; other site 290338005983 ATP binding site [chemical binding]; other site 290338005984 Q-loop/lid; other site 290338005985 ABC transporter signature motif; other site 290338005986 Walker B; other site 290338005987 D-loop; other site 290338005988 H-loop/switch region; other site 290338005989 aminopeptidase N; Provisional; Region: pepN; PRK14015 290338005990 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 290338005991 active site 290338005992 Zn binding site [ion binding]; other site 290338005993 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 290338005994 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 290338005995 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 290338005996 active site 290338005997 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 290338005998 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 290338005999 putative dimer interface [polypeptide binding]; other site 290338006000 putative anticodon binding site; other site 290338006001 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 290338006002 homodimer interface [polypeptide binding]; other site 290338006003 motif 1; other site 290338006004 motif 2; other site 290338006005 active site 290338006006 motif 3; other site 290338006007 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338006008 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338006009 trimer interface [polypeptide binding]; other site 290338006010 eyelet of channel; other site 290338006011 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 290338006012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338006013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338006014 homodimer interface [polypeptide binding]; other site 290338006015 catalytic residue [active] 290338006016 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290338006017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 290338006018 Peptidase M15; Region: Peptidase_M15_3; cl01194 290338006019 murein L,D-transpeptidase; Provisional; Region: PRK10594 290338006020 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290338006021 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338006022 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338006023 cell division protein MukB; Provisional; Region: mukB; PRK04863 290338006024 P-loop containing region of AAA domain; Region: AAA_29; cl17516 290338006025 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290338006026 condesin subunit E; Provisional; Region: PRK05256 290338006027 condesin subunit F; Provisional; Region: PRK05260 290338006028 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290338006029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338006030 S-adenosylmethionine binding site [chemical binding]; other site 290338006031 Uncharacterized conserved protein [Function unknown]; Region: COG1434 290338006032 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290338006033 putative active site [active] 290338006034 hypothetical protein; Provisional; Region: PRK10593 290338006035 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 290338006036 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 290338006037 Ligand binding site; other site 290338006038 oligomer interface; other site 290338006039 hypothetical protein; Provisional; Region: PRK11827 290338006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 290338006041 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290338006042 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 290338006043 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 290338006044 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 290338006045 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338006046 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 290338006047 Walker A/P-loop; other site 290338006048 ATP binding site [chemical binding]; other site 290338006049 Q-loop/lid; other site 290338006050 ABC transporter signature motif; other site 290338006051 Walker B; other site 290338006052 D-loop; other site 290338006053 H-loop/switch region; other site 290338006054 ComEC family competence protein; Provisional; Region: PRK11539 290338006055 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 290338006056 Competence protein; Region: Competence; pfam03772 290338006057 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 290338006058 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290338006059 IHF dimer interface [polypeptide binding]; other site 290338006060 IHF - DNA interface [nucleotide binding]; other site 290338006061 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 290338006062 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 290338006063 RNA binding site [nucleotide binding]; other site 290338006064 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290338006065 RNA binding site [nucleotide binding]; other site 290338006066 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 290338006067 RNA binding site [nucleotide binding]; other site 290338006068 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 290338006069 RNA binding site [nucleotide binding]; other site 290338006070 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290338006071 RNA binding site [nucleotide binding]; other site 290338006072 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 290338006073 RNA binding site [nucleotide binding]; other site 290338006074 cytidylate kinase; Provisional; Region: cmk; PRK00023 290338006075 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290338006076 CMP-binding site; other site 290338006077 The sites determining sugar specificity; other site 290338006078 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 290338006079 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 290338006080 putative active site [active] 290338006081 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 290338006082 homodimer interface [polypeptide binding]; other site 290338006083 substrate-cofactor binding pocket; other site 290338006084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338006085 catalytic residue [active] 290338006086 uncharacterized domain; Region: TIGR00702 290338006087 YcaO-like family; Region: YcaO; pfam02624 290338006088 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 290338006089 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 290338006090 Pyruvate formate lyase 1; Region: PFL1; cd01678 290338006091 coenzyme A binding site [chemical binding]; other site 290338006092 active site 290338006093 catalytic residues [active] 290338006094 glycine loop; other site 290338006095 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 290338006096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338006097 FeS/SAM binding site; other site 290338006098 putative MFS family transporter protein; Provisional; Region: PRK03633 290338006099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338006100 putative substrate translocation pore; other site 290338006101 Isochorismatase family; Region: Isochorismatase; pfam00857 290338006102 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 290338006103 catalytic triad [active] 290338006104 dimer interface [polypeptide binding]; other site 290338006105 conserved cis-peptide bond; other site 290338006106 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 290338006107 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 290338006108 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 290338006109 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 290338006110 putative [Fe4-S4] binding site [ion binding]; other site 290338006111 putative molybdopterin cofactor binding site [chemical binding]; other site 290338006112 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 290338006113 putative molybdopterin cofactor binding site; other site 290338006114 seryl-tRNA synthetase; Provisional; Region: PRK05431 290338006115 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290338006116 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 290338006117 dimer interface [polypeptide binding]; other site 290338006118 active site 290338006119 motif 1; other site 290338006120 motif 2; other site 290338006121 motif 3; other site 290338006122 recombination factor protein RarA; Reviewed; Region: PRK13342 290338006123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338006124 Walker A motif; other site 290338006125 ATP binding site [chemical binding]; other site 290338006126 Walker B motif; other site 290338006127 arginine finger; other site 290338006128 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290338006129 periplasmic chaperone LolA; Region: lolA; TIGR00547 290338006130 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 290338006131 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 290338006132 DNA translocase FtsK; Provisional; Region: PRK10263 290338006133 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290338006134 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 290338006135 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 290338006136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290338006137 putative DNA binding site [nucleotide binding]; other site 290338006138 putative Zn2+ binding site [ion binding]; other site 290338006139 AsnC family; Region: AsnC_trans_reg; pfam01037 290338006140 thioredoxin reductase; Provisional; Region: PRK10262 290338006141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338006142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338006143 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 290338006144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338006145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006146 Walker A/P-loop; other site 290338006147 ATP binding site [chemical binding]; other site 290338006148 Q-loop/lid; other site 290338006149 ABC transporter signature motif; other site 290338006150 Walker B; other site 290338006151 D-loop; other site 290338006152 H-loop/switch region; other site 290338006153 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 290338006154 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338006155 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 290338006156 Walker A/P-loop; other site 290338006157 ATP binding site [chemical binding]; other site 290338006158 Q-loop/lid; other site 290338006159 ABC transporter signature motif; other site 290338006160 Walker B; other site 290338006161 D-loop; other site 290338006162 H-loop/switch region; other site 290338006163 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 290338006164 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290338006165 rRNA binding site [nucleotide binding]; other site 290338006166 predicted 30S ribosome binding site; other site 290338006167 LysR family transcriptional regulator; Provisional; Region: PRK14997 290338006168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338006169 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 290338006170 putative effector binding pocket; other site 290338006171 putative dimerization interface [polypeptide binding]; other site 290338006172 Pirin-related protein [General function prediction only]; Region: COG1741 290338006173 Pirin; Region: Pirin; pfam02678 290338006174 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 290338006175 Isochorismatase family; Region: Isochorismatase; pfam00857 290338006176 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 290338006177 catalytic triad [active] 290338006178 dimer interface [polypeptide binding]; other site 290338006179 conserved cis-peptide bond; other site 290338006180 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 290338006181 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 290338006182 Clp amino terminal domain; Region: Clp_N; pfam02861 290338006183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338006184 Walker A motif; other site 290338006185 ATP binding site [chemical binding]; other site 290338006186 Walker B motif; other site 290338006187 arginine finger; other site 290338006188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338006189 Walker A motif; other site 290338006190 ATP binding site [chemical binding]; other site 290338006191 Walker B motif; other site 290338006192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290338006193 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 290338006194 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290338006195 DNA-binding site [nucleotide binding]; DNA binding site 290338006196 RNA-binding motif; other site 290338006197 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 290338006198 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290338006199 Walker A/P-loop; other site 290338006200 ATP binding site [chemical binding]; other site 290338006201 Q-loop/lid; other site 290338006202 ABC transporter signature motif; other site 290338006203 Walker B; other site 290338006204 D-loop; other site 290338006205 H-loop/switch region; other site 290338006206 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290338006207 FtsX-like permease family; Region: FtsX; pfam02687 290338006208 macrolide transporter subunit MacA; Provisional; Region: PRK11578 290338006209 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338006210 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338006211 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 290338006212 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 290338006213 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 290338006214 putative active site [active] 290338006215 putative metal-binding site [ion binding]; other site 290338006216 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290338006217 amphipathic channel; other site 290338006218 Asn-Pro-Ala signature motifs; other site 290338006219 Predicted membrane protein [Function unknown]; Region: COG2431 290338006220 hybrid cluster protein; Provisional; Region: PRK05290 290338006221 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338006222 ACS interaction site; other site 290338006223 CODH interaction site; other site 290338006224 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 290338006225 hybrid metal cluster; other site 290338006226 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 290338006227 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 290338006228 FAD binding pocket [chemical binding]; other site 290338006229 FAD binding motif [chemical binding]; other site 290338006230 phosphate binding motif [ion binding]; other site 290338006231 beta-alpha-beta structure motif; other site 290338006232 NAD binding pocket [chemical binding]; other site 290338006233 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290338006234 catalytic loop [active] 290338006235 iron binding site [ion binding]; other site 290338006236 DoxX; Region: DoxX; pfam07681 290338006237 pyruvate dehydrogenase; Provisional; Region: PRK09124 290338006238 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290338006239 PYR/PP interface [polypeptide binding]; other site 290338006240 dimer interface [polypeptide binding]; other site 290338006241 tetramer interface [polypeptide binding]; other site 290338006242 TPP binding site [chemical binding]; other site 290338006243 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290338006244 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 290338006245 TPP-binding site [chemical binding]; other site 290338006246 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 290338006247 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290338006248 tetramer interface [polypeptide binding]; other site 290338006249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338006250 catalytic residue [active] 290338006251 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290338006252 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 290338006253 putative NAD(P) binding site [chemical binding]; other site 290338006254 putative active site [active] 290338006255 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 290338006256 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290338006257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338006258 NAD(P) binding site [chemical binding]; other site 290338006259 active site 290338006260 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 290338006261 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 290338006262 putative sugar binding site [chemical binding]; other site 290338006263 catalytic residues [active] 290338006264 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 290338006265 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 290338006266 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290338006267 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 290338006268 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338006269 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338006270 catalytic residue [active] 290338006271 N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848 290338006272 Glyco_18 domain; Region: Glyco_18; smart00636 290338006273 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 290338006274 active site 290338006275 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 290338006276 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290338006277 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 290338006278 aromatic chitin/cellulose binding site residues [chemical binding]; other site 290338006279 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 290338006280 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 290338006281 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 290338006282 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 290338006283 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 290338006284 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 290338006285 GspL periplasmic domain; Region: GspL_C; cl14909 290338006286 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 290338006287 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 290338006288 type II secretion system protein J; Region: gspJ; TIGR01711 290338006289 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 290338006290 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 290338006291 type II secretion system protein I; Region: gspI; TIGR01707 290338006292 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 290338006293 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 290338006294 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 290338006295 Type II transport protein GspH; Region: GspH; pfam12019 290338006296 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 290338006297 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 290338006298 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 290338006299 type II secretion system protein F; Region: GspF; TIGR02120 290338006300 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290338006301 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290338006302 type II secretion system protein E; Region: type_II_gspE; TIGR02533 290338006303 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 290338006304 Walker A motif; other site 290338006305 ATP binding site [chemical binding]; other site 290338006306 Walker B motif; other site 290338006307 type II secretion system protein D; Region: type_II_gspD; TIGR02517 290338006308 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 290338006309 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 290338006310 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 290338006311 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 290338006312 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 290338006313 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 290338006314 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290338006315 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 290338006316 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290338006317 ligand binding site [chemical binding]; other site 290338006318 flexible hinge region; other site 290338006319 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 290338006320 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 290338006321 amidase catalytic site [active] 290338006322 Zn binding residues [ion binding]; other site 290338006323 substrate binding site [chemical binding]; other site 290338006324 hypothetical protein; Provisional; Region: PRK02877 290338006325 putative lipoprotein; Provisional; Region: PRK10533 290338006326 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 290338006327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006328 Walker A/P-loop; other site 290338006329 ATP binding site [chemical binding]; other site 290338006330 Q-loop/lid; other site 290338006331 ABC transporter signature motif; other site 290338006332 Walker B; other site 290338006333 D-loop; other site 290338006334 H-loop/switch region; other site 290338006335 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 290338006336 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338006337 substrate binding pocket [chemical binding]; other site 290338006338 membrane-bound complex binding site; other site 290338006339 hinge residues; other site 290338006340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338006341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006342 dimer interface [polypeptide binding]; other site 290338006343 conserved gate region; other site 290338006344 putative PBP binding loops; other site 290338006345 ABC-ATPase subunit interface; other site 290338006346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290338006347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006348 dimer interface [polypeptide binding]; other site 290338006349 conserved gate region; other site 290338006350 putative PBP binding loops; other site 290338006351 ABC-ATPase subunit interface; other site 290338006352 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290338006353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338006354 substrate binding pocket [chemical binding]; other site 290338006355 membrane-bound complex binding site; other site 290338006356 hinge residues; other site 290338006357 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 290338006358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338006359 dimer interface [polypeptide binding]; other site 290338006360 phosphorylation site [posttranslational modification] 290338006361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338006362 ATP binding site [chemical binding]; other site 290338006363 Mg2+ binding site [ion binding]; other site 290338006364 G-X-G motif; other site 290338006365 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290338006366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338006367 active site 290338006368 phosphorylation site [posttranslational modification] 290338006369 intermolecular recognition site; other site 290338006370 dimerization interface [polypeptide binding]; other site 290338006371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338006372 DNA binding site [nucleotide binding] 290338006373 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 290338006374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338006375 S-adenosylmethionine binding site [chemical binding]; other site 290338006376 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 290338006377 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290338006378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006379 putative PBP binding loops; other site 290338006380 dimer interface [polypeptide binding]; other site 290338006381 ABC-ATPase subunit interface; other site 290338006382 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290338006383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006384 dimer interface [polypeptide binding]; other site 290338006385 conserved gate region; other site 290338006386 putative PBP binding loops; other site 290338006387 ABC-ATPase subunit interface; other site 290338006388 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 290338006389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006390 Walker A/P-loop; other site 290338006391 ATP binding site [chemical binding]; other site 290338006392 Q-loop/lid; other site 290338006393 ABC transporter signature motif; other site 290338006394 Walker B; other site 290338006395 D-loop; other site 290338006396 H-loop/switch region; other site 290338006397 TOBE domain; Region: TOBE_2; pfam08402 290338006398 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 290338006399 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290338006400 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 290338006401 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 290338006402 RimK-like ATP-grasp domain; Region: RimK; pfam08443 290338006403 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 290338006404 dimer interface [polypeptide binding]; other site 290338006405 FMN binding site [chemical binding]; other site 290338006406 NADPH bind site [chemical binding]; other site 290338006407 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 290338006408 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 290338006409 GSH binding site [chemical binding]; other site 290338006410 catalytic residues [active] 290338006411 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 290338006412 putative transporter; Provisional; Region: PRK04972 290338006413 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 290338006414 TrkA-C domain; Region: TrkA_C; pfam02080 290338006415 TrkA-C domain; Region: TrkA_C; pfam02080 290338006416 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 290338006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 290338006418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338006419 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290338006420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338006421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338006422 putative substrate translocation pore; other site 290338006423 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 290338006424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338006425 active site 290338006426 motif I; other site 290338006427 motif II; other site 290338006428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338006429 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 290338006430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338006431 putative substrate translocation pore; other site 290338006432 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290338006433 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 290338006434 active site 290338006435 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 290338006436 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290338006437 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338006438 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 290338006439 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 290338006440 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 290338006441 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 290338006442 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 290338006443 putative C-terminal domain interface [polypeptide binding]; other site 290338006444 putative GSH binding site (G-site) [chemical binding]; other site 290338006445 putative dimer interface [polypeptide binding]; other site 290338006446 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 290338006447 putative N-terminal domain interface [polypeptide binding]; other site 290338006448 putative dimer interface [polypeptide binding]; other site 290338006449 putative substrate binding pocket (H-site) [chemical binding]; other site 290338006450 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 290338006451 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 290338006452 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 290338006453 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 290338006454 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 290338006455 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290338006456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006457 dimer interface [polypeptide binding]; other site 290338006458 conserved gate region; other site 290338006459 putative PBP binding loops; other site 290338006460 ABC-ATPase subunit interface; other site 290338006461 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 290338006462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006463 dimer interface [polypeptide binding]; other site 290338006464 conserved gate region; other site 290338006465 putative PBP binding loops; other site 290338006466 ABC-ATPase subunit interface; other site 290338006467 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 290338006468 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 290338006469 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 290338006470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338006471 Walker A/P-loop; other site 290338006472 ATP binding site [chemical binding]; other site 290338006473 Q-loop/lid; other site 290338006474 ABC transporter signature motif; other site 290338006475 Walker B; other site 290338006476 D-loop; other site 290338006477 H-loop/switch region; other site 290338006478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338006479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338006480 Walker A/P-loop; other site 290338006481 ATP binding site [chemical binding]; other site 290338006482 Q-loop/lid; other site 290338006483 ABC transporter signature motif; other site 290338006484 Walker B; other site 290338006485 D-loop; other site 290338006486 H-loop/switch region; other site 290338006487 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290338006488 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 290338006489 catalytic nucleophile [active] 290338006490 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 290338006491 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290338006492 dimer interface [polypeptide binding]; other site 290338006493 putative functional site; other site 290338006494 putative MPT binding site; other site 290338006495 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 290338006496 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290338006497 ATP binding site [chemical binding]; other site 290338006498 substrate interface [chemical binding]; other site 290338006499 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 290338006500 active site 290338006501 intersubunit interactions; other site 290338006502 catalytic residue [active] 290338006503 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 290338006504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338006505 FeS/SAM binding site; other site 290338006506 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 290338006507 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 290338006508 dimer interface [polypeptide binding]; other site 290338006509 active site 290338006510 glycine loop; other site 290338006511 Protein of unknown function (DUF796); Region: DUF796; cl01226 290338006512 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 290338006513 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 290338006514 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 290338006515 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 290338006516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338006517 active site 290338006518 motif I; other site 290338006519 motif II; other site 290338006520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338006521 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 290338006522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338006523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338006524 DNA binding site [nucleotide binding] 290338006525 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290338006526 ligand binding site [chemical binding]; other site 290338006527 dimerization interface [polypeptide binding]; other site 290338006528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338006529 D-galactonate transporter; Region: 2A0114; TIGR00893 290338006530 putative substrate translocation pore; other site 290338006531 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 290338006532 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290338006533 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 290338006534 putative active site [active] 290338006535 putative catalytic site [active] 290338006536 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 290338006537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338006538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006539 Walker A/P-loop; other site 290338006540 ATP binding site [chemical binding]; other site 290338006541 ABC transporter signature motif; other site 290338006542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338006543 Walker B; other site 290338006544 ABC transporter; Region: ABC_tran_2; pfam12848 290338006545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338006546 L,D-transpeptidase; Provisional; Region: PRK10260 290338006547 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338006548 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 290338006549 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338006550 transmembrane helices; other site 290338006551 manganese transport regulator MntR; Provisional; Region: PRK11050 290338006552 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290338006553 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290338006554 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 290338006555 Sulfatase; Region: Sulfatase; pfam00884 290338006556 outer membrane protein X; Provisional; Region: ompX; PRK09408 290338006557 threonine and homoserine efflux system; Provisional; Region: PRK10532 290338006558 EamA-like transporter family; Region: EamA; pfam00892 290338006559 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 290338006560 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 290338006561 dimerization interface [polypeptide binding]; other site 290338006562 DPS ferroxidase diiron center [ion binding]; other site 290338006563 ion pore; other site 290338006564 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 290338006565 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338006566 substrate binding pocket [chemical binding]; other site 290338006567 membrane-bound complex binding site; other site 290338006568 hinge residues; other site 290338006569 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338006570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006571 dimer interface [polypeptide binding]; other site 290338006572 conserved gate region; other site 290338006573 putative PBP binding loops; other site 290338006574 ABC-ATPase subunit interface; other site 290338006575 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 290338006576 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290338006577 Walker A/P-loop; other site 290338006578 ATP binding site [chemical binding]; other site 290338006579 Q-loop/lid; other site 290338006580 ABC transporter signature motif; other site 290338006581 Walker B; other site 290338006582 D-loop; other site 290338006583 H-loop/switch region; other site 290338006584 putative mechanosensitive channel protein; Provisional; Region: PRK11465 290338006585 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290338006586 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 290338006587 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 290338006588 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 290338006589 hypothetical protein; Provisional; Region: PRK11019 290338006590 hypothetical protein; Provisional; Region: PRK10259 290338006591 glycosyl transferase family protein; Provisional; Region: PRK08136 290338006592 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290338006593 Fimbrial protein; Region: Fimbrial; cl01416 290338006594 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338006595 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338006596 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338006597 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338006598 PapC N-terminal domain; Region: PapC_N; pfam13954 290338006599 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338006600 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338006601 PapC C-terminal domain; Region: PapC_C; pfam13953 290338006602 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338006603 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338006604 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 290338006605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290338006606 DEAD_2; Region: DEAD_2; pfam06733 290338006607 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 290338006608 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 290338006609 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290338006610 ATP binding site [chemical binding]; other site 290338006611 Mg++ binding site [ion binding]; other site 290338006612 motif III; other site 290338006613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338006614 nucleotide binding region [chemical binding]; other site 290338006615 ATP-binding site [chemical binding]; other site 290338006616 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 290338006617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338006618 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 290338006619 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 290338006620 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338006621 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338006622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290338006623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290338006624 Walker A/P-loop; other site 290338006625 ATP binding site [chemical binding]; other site 290338006626 Q-loop/lid; other site 290338006627 ABC transporter signature motif; other site 290338006628 Walker B; other site 290338006629 D-loop; other site 290338006630 H-loop/switch region; other site 290338006631 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290338006632 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290338006633 Walker A/P-loop; other site 290338006634 ATP binding site [chemical binding]; other site 290338006635 Q-loop/lid; other site 290338006636 ABC transporter signature motif; other site 290338006637 Walker B; other site 290338006638 D-loop; other site 290338006639 H-loop/switch region; other site 290338006640 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290338006641 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 290338006642 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290338006643 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 290338006644 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 290338006645 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 290338006646 putative catalytic site [active] 290338006647 putative metal binding site [ion binding]; other site 290338006648 putative phosphate binding site [ion binding]; other site 290338006649 cardiolipin synthase 2; Provisional; Region: PRK11263 290338006650 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 290338006651 putative active site [active] 290338006652 catalytic site [active] 290338006653 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 290338006654 putative active site [active] 290338006655 catalytic site [active] 290338006656 Predicted integral membrane protein [Function unknown]; Region: COG0392 290338006657 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 290338006658 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 290338006659 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 290338006660 MoaE homodimer interface [polypeptide binding]; other site 290338006661 MoaD interaction [polypeptide binding]; other site 290338006662 active site residues [active] 290338006663 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 290338006664 MoaE interaction surface [polypeptide binding]; other site 290338006665 MoeB interaction surface [polypeptide binding]; other site 290338006666 thiocarboxylated glycine; other site 290338006667 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 290338006668 trimer interface [polypeptide binding]; other site 290338006669 dimer interface [polypeptide binding]; other site 290338006670 putative active site [active] 290338006671 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290338006672 MPT binding site; other site 290338006673 trimer interface [polypeptide binding]; other site 290338006674 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 290338006675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338006676 FeS/SAM binding site; other site 290338006677 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290338006678 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 290338006679 dimer interface [polypeptide binding]; other site 290338006680 phosphate binding site [ion binding]; other site 290338006681 excinuclease ABC subunit B; Provisional; Region: PRK05298 290338006682 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338006683 ATP binding site [chemical binding]; other site 290338006684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338006685 nucleotide binding region [chemical binding]; other site 290338006686 ATP-binding site [chemical binding]; other site 290338006687 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290338006688 UvrB/uvrC motif; Region: UVR; pfam02151 290338006689 AAA domain; Region: AAA_26; pfam13500 290338006690 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 290338006691 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 290338006692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338006693 S-adenosylmethionine binding site [chemical binding]; other site 290338006694 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290338006695 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 290338006696 substrate-cofactor binding pocket; other site 290338006697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338006698 catalytic residue [active] 290338006699 biotin synthase; Provisional; Region: PRK15108 290338006700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338006701 FeS/SAM binding site; other site 290338006702 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 290338006703 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 290338006704 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338006705 inhibitor-cofactor binding pocket; inhibition site 290338006706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338006707 catalytic residue [active] 290338006708 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 290338006709 substrate binding site [chemical binding]; other site 290338006710 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290338006711 active sites [active] 290338006712 tetramer interface [polypeptide binding]; other site 290338006713 urocanate hydratase; Provisional; Region: PRK05414 290338006714 histidine utilization repressor; Provisional; Region: PRK14999 290338006715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338006716 DNA-binding site [nucleotide binding]; DNA binding site 290338006717 UTRA domain; Region: UTRA; pfam07702 290338006718 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 290338006719 putative active site [active] 290338006720 putative metal binding site [ion binding]; other site 290338006721 imidazolonepropionase; Validated; Region: PRK09356 290338006722 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 290338006723 active site 290338006724 acyl-CoA thioesterase; Provisional; Region: PRK10531 290338006725 putative pectinesterase; Region: PLN02432; cl01911 290338006726 putative hydratase; Provisional; Region: PRK11413 290338006727 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290338006728 substrate binding site [chemical binding]; other site 290338006729 ligand binding site [chemical binding]; other site 290338006730 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 290338006731 substrate binding site [chemical binding]; other site 290338006732 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338006733 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 290338006734 transmembrane helices; other site 290338006735 PrpF protein; Region: PrpF; pfam04303 290338006736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338006737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338006738 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 290338006739 putative dimerization interface [polypeptide binding]; other site 290338006740 6-phosphogluconolactonase; Provisional; Region: PRK11028 290338006741 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 290338006742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338006743 motif II; other site 290338006744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338006745 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 290338006746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006747 Walker A/P-loop; other site 290338006748 ATP binding site [chemical binding]; other site 290338006749 Q-loop/lid; other site 290338006750 ABC transporter signature motif; other site 290338006751 Walker B; other site 290338006752 D-loop; other site 290338006753 H-loop/switch region; other site 290338006754 molybdenum-pterin binding domain; Region: Mop; TIGR00638 290338006755 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290338006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338006757 dimer interface [polypeptide binding]; other site 290338006758 conserved gate region; other site 290338006759 putative PBP binding loops; other site 290338006760 ABC-ATPase subunit interface; other site 290338006761 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 290338006762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338006763 substrate binding pocket [chemical binding]; other site 290338006764 membrane-bound complex binding site; other site 290338006765 hinge residues; other site 290338006766 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 290338006767 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 290338006768 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 290338006769 molybdenum-pterin binding domain; Region: Mop; TIGR00638 290338006770 TOBE domain; Region: TOBE; pfam03459 290338006771 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 290338006772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006773 Walker A/P-loop; other site 290338006774 ATP binding site [chemical binding]; other site 290338006775 Q-loop/lid; other site 290338006776 ABC transporter signature motif; other site 290338006777 Walker B; other site 290338006778 D-loop; other site 290338006779 H-loop/switch region; other site 290338006780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338006781 Walker A/P-loop; other site 290338006782 ATP binding site [chemical binding]; other site 290338006783 Q-loop/lid; other site 290338006784 ABC transporter signature motif; other site 290338006785 Walker B; other site 290338006786 D-loop; other site 290338006787 H-loop/switch region; other site 290338006788 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 290338006789 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290338006790 NAD binding site [chemical binding]; other site 290338006791 homodimer interface [polypeptide binding]; other site 290338006792 active site 290338006793 substrate binding site [chemical binding]; other site 290338006794 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 290338006795 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 290338006796 dimer interface [polypeptide binding]; other site 290338006797 active site 290338006798 galactokinase; Provisional; Region: PRK05101 290338006799 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 290338006800 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290338006801 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 290338006802 active site 290338006803 catalytic residues [active] 290338006804 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290338006805 catalytic core [active] 290338006806 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290338006807 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290338006808 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338006809 Walker A/P-loop; other site 290338006810 ATP binding site [chemical binding]; other site 290338006811 Q-loop/lid; other site 290338006812 ABC transporter signature motif; other site 290338006813 Walker B; other site 290338006814 D-loop; other site 290338006815 H-loop/switch region; other site 290338006816 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338006817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338006818 dimer interface [polypeptide binding]; other site 290338006819 putative PBP binding regions; other site 290338006820 ABC-ATPase subunit interface; other site 290338006821 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 290338006822 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290338006823 putative ligand binding residues [chemical binding]; other site 290338006824 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338006825 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338006826 N-terminal plug; other site 290338006827 ligand-binding site [chemical binding]; other site 290338006828 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 290338006829 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290338006830 YbgS-like protein; Region: YbgS; pfam13985 290338006831 zinc transporter ZitB; Provisional; Region: PRK03557 290338006832 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 290338006833 quinolinate synthetase; Provisional; Region: PRK09375 290338006834 tol-pal system protein YbgF; Provisional; Region: PRK10803 290338006835 Tetratricopeptide repeat; Region: TPR_6; pfam13174 290338006836 Tetratricopeptide repeat; Region: TPR_6; pfam13174 290338006837 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 290338006838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290338006839 ligand binding site [chemical binding]; other site 290338006840 translocation protein TolB; Provisional; Region: tolB; PRK03629 290338006841 TolB amino-terminal domain; Region: TolB_N; pfam04052 290338006842 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290338006843 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290338006844 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290338006845 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 290338006846 TolA C-terminal; Region: TolA; pfam06519 290338006847 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 290338006848 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 290338006849 colicin uptake protein TolR; Provisional; Region: PRK11024 290338006850 colicin uptake protein TolQ; Provisional; Region: PRK10801 290338006851 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290338006852 active site 290338006853 hypothetical protein; Provisional; Region: PRK10588 290338006854 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 290338006855 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 290338006856 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 290338006857 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 290338006858 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 290338006859 alpha-mannosidase; Provisional; Region: PRK09819 290338006860 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 290338006861 active site 290338006862 metal binding site [ion binding]; metal-binding site 290338006863 catalytic site [active] 290338006864 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 290338006865 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 290338006866 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338006867 active site 290338006868 phosphorylation site [posttranslational modification] 290338006869 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290338006870 active site 290338006871 P-loop; other site 290338006872 phosphorylation site [posttranslational modification] 290338006873 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290338006874 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 290338006875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338006876 DNA-binding site [nucleotide binding]; DNA binding site 290338006877 UTRA domain; Region: UTRA; pfam07702 290338006878 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 290338006879 B12 binding site [chemical binding]; other site 290338006880 heterodimer interface [polypeptide binding]; other site 290338006881 cobalt ligand [ion binding]; other site 290338006882 conserved hypothetical protein; Region: glmL_fam; TIGR01319 290338006883 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 290338006884 substrate binding site [chemical binding]; other site 290338006885 B12 cofactor binding site [chemical binding]; other site 290338006886 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 290338006887 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 290338006888 Methylaspartate ammonia-lyase [Amino acid transport and metabolism]; Region: Mal; COG3799 290338006889 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 290338006890 dimer interface [polypeptide binding]; other site 290338006891 active site 290338006892 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 290338006893 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 290338006894 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338006895 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290338006896 putative fumarate hydratase; Provisional; Region: PRK15392 290338006897 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 290338006898 Fumarase C-terminus; Region: Fumerase_C; pfam05683 290338006899 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 290338006900 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 290338006901 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 290338006902 homodimer interface [polypeptide binding]; other site 290338006903 Walker A motif; other site 290338006904 ATP binding site [chemical binding]; other site 290338006905 hydroxycobalamin binding site [chemical binding]; other site 290338006906 Walker B motif; other site 290338006907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338006908 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 290338006909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338006910 dimerization interface [polypeptide binding]; other site 290338006911 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290338006912 CoA binding domain; Region: CoA_binding; smart00881 290338006913 CoA-ligase; Region: Ligase_CoA; pfam00549 290338006914 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290338006915 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290338006916 CoA-ligase; Region: Ligase_CoA; pfam00549 290338006917 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 290338006918 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290338006919 E3 interaction surface; other site 290338006920 lipoyl attachment site [posttranslational modification]; other site 290338006921 e3 binding domain; Region: E3_binding; pfam02817 290338006922 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290338006923 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 290338006924 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290338006925 TPP-binding site [chemical binding]; other site 290338006926 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 290338006927 dimer interface [polypeptide binding]; other site 290338006928 PYR/PP interface [polypeptide binding]; other site 290338006929 TPP binding site [chemical binding]; other site 290338006930 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 290338006931 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290338006932 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 290338006933 L-aspartate oxidase; Provisional; Region: PRK06175 290338006934 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290338006935 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 290338006936 SdhC subunit interface [polypeptide binding]; other site 290338006937 proximal heme binding site [chemical binding]; other site 290338006938 cardiolipin binding site; other site 290338006939 Iron-sulfur protein interface; other site 290338006940 proximal quinone binding site [chemical binding]; other site 290338006941 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 290338006942 Iron-sulfur protein interface; other site 290338006943 proximal quinone binding site [chemical binding]; other site 290338006944 SdhD (CybS) interface [polypeptide binding]; other site 290338006945 proximal heme binding site [chemical binding]; other site 290338006946 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 290338006947 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 290338006948 dimer interface [polypeptide binding]; other site 290338006949 active site 290338006950 citrylCoA binding site [chemical binding]; other site 290338006951 NADH binding [chemical binding]; other site 290338006952 cationic pore residues; other site 290338006953 oxalacetate/citrate binding site [chemical binding]; other site 290338006954 coenzyme A binding site [chemical binding]; other site 290338006955 catalytic triad [active] 290338006956 Protein of unknown function (DUF796); Region: DUF796; cl01226 290338006957 S-type Pyocin; Region: Pyocin_S; pfam06958 290338006958 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 290338006959 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 290338006960 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 290338006961 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 290338006962 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 290338006963 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 290338006964 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 290338006965 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 290338006966 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 290338006967 galactoside permease; Reviewed; Region: lacY; PRK09528 290338006968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338006969 putative substrate translocation pore; other site 290338006970 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 290338006971 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338006972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338006973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338006974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338006975 endonuclease VIII; Provisional; Region: PRK10445 290338006976 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 290338006977 DNA binding site [nucleotide binding] 290338006978 catalytic residue [active] 290338006979 putative catalytic residues [active] 290338006980 H2TH interface [polypeptide binding]; other site 290338006981 intercalation triad [nucleotide binding]; other site 290338006982 substrate specificity determining residue; other site 290338006983 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290338006984 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290338006985 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 290338006986 putative substrate binding pocket [chemical binding]; other site 290338006987 AC domain interface; other site 290338006988 catalytic triad [active] 290338006989 AB domain interface; other site 290338006990 interchain disulfide; other site 290338006991 Predicted membrane protein [Function unknown]; Region: COG3817 290338006992 Protein of unknown function (DUF979); Region: DUF979; pfam06166 290338006993 Protein of unknown function (DUF969); Region: DUF969; pfam06149 290338006994 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 290338006995 putative active site [active] 290338006996 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 290338006997 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290338006998 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 290338006999 Uncharacterized conserved protein [Function unknown]; Region: COG0327 290338007000 metal-binding protein; Provisional; Region: PRK10799 290338007001 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 290338007002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007003 putative substrate translocation pore; other site 290338007004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007005 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 290338007006 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 290338007007 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 290338007008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290338007009 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 290338007010 sensor protein KdpD; Provisional; Region: PRK10490 290338007011 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 290338007012 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 290338007013 Ligand Binding Site [chemical binding]; other site 290338007014 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 290338007015 GAF domain; Region: GAF_3; pfam13492 290338007016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338007017 dimer interface [polypeptide binding]; other site 290338007018 phosphorylation site [posttranslational modification] 290338007019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338007020 ATP binding site [chemical binding]; other site 290338007021 Mg2+ binding site [ion binding]; other site 290338007022 G-X-G motif; other site 290338007023 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 290338007024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338007025 active site 290338007026 phosphorylation site [posttranslational modification] 290338007027 intermolecular recognition site; other site 290338007028 dimerization interface [polypeptide binding]; other site 290338007029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338007030 DNA binding site [nucleotide binding] 290338007031 ornithine decarboxylase; Provisional; Region: PRK13578 290338007032 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 290338007033 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 290338007034 homodimer interface [polypeptide binding]; other site 290338007035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338007036 catalytic residue [active] 290338007037 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 290338007038 putrescine transporter; Provisional; Region: potE; PRK10655 290338007039 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 290338007040 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 290338007041 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 290338007042 active site 290338007043 substrate binding site [chemical binding]; other site 290338007044 metal binding site [ion binding]; metal-binding site 290338007045 replication initiation regulator SeqA; Provisional; Region: PRK11187 290338007046 acyl-CoA esterase; Provisional; Region: PRK10673 290338007047 PGAP1-like protein; Region: PGAP1; pfam07819 290338007048 LexA regulated protein; Provisional; Region: PRK11675 290338007049 flavodoxin FldA; Validated; Region: PRK09267 290338007050 ferric uptake regulator; Provisional; Region: fur; PRK09462 290338007051 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290338007052 metal binding site 2 [ion binding]; metal-binding site 290338007053 putative DNA binding helix; other site 290338007054 metal binding site 1 [ion binding]; metal-binding site 290338007055 dimer interface [polypeptide binding]; other site 290338007056 structural Zn2+ binding site [ion binding]; other site 290338007057 YbfN-like lipoprotein; Region: YbfN; pfam13982 290338007058 outer membrane porin, OprD family; Region: OprD; pfam03573 290338007059 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 290338007060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290338007061 active site 290338007062 HIGH motif; other site 290338007063 nucleotide binding site [chemical binding]; other site 290338007064 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 290338007065 KMSKS motif; other site 290338007066 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 290338007067 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 290338007068 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290338007069 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338007070 active site turn [active] 290338007071 phosphorylation site [posttranslational modification] 290338007072 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 290338007073 HPr interaction site; other site 290338007074 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290338007075 active site 290338007076 phosphorylation site [posttranslational modification] 290338007077 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290338007078 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290338007079 active site 290338007080 trimer interface [polypeptide binding]; other site 290338007081 allosteric site; other site 290338007082 active site lid [active] 290338007083 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290338007084 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 290338007085 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 290338007086 active site 290338007087 dimer interface [polypeptide binding]; other site 290338007088 MarR family; Region: MarR; pfam01047 290338007089 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290338007090 ROK family; Region: ROK; pfam00480 290338007091 UMP phosphatase; Provisional; Region: PRK10444 290338007092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338007093 active site 290338007094 motif I; other site 290338007095 motif II; other site 290338007096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338007097 asparagine synthetase B; Provisional; Region: asnB; PRK09431 290338007098 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 290338007099 active site 290338007100 dimer interface [polypeptide binding]; other site 290338007101 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 290338007102 Ligand Binding Site [chemical binding]; other site 290338007103 Molecular Tunnel; other site 290338007104 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 290338007105 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290338007106 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 290338007107 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290338007108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338007109 FeS/SAM binding site; other site 290338007110 TRAM domain; Region: TRAM; pfam01938 290338007111 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290338007112 PhoH-like protein; Region: PhoH; pfam02562 290338007113 metal-binding heat shock protein; Provisional; Region: PRK00016 290338007114 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 290338007115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290338007116 Transporter associated domain; Region: CorC_HlyC; smart01091 290338007117 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 290338007118 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 290338007119 putative active site [active] 290338007120 catalytic triad [active] 290338007121 putative dimer interface [polypeptide binding]; other site 290338007122 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 290338007123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338007124 substrate binding pocket [chemical binding]; other site 290338007125 membrane-bound complex binding site; other site 290338007126 hinge residues; other site 290338007127 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338007128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338007129 dimer interface [polypeptide binding]; other site 290338007130 conserved gate region; other site 290338007131 putative PBP binding loops; other site 290338007132 ABC-ATPase subunit interface; other site 290338007133 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290338007134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338007135 dimer interface [polypeptide binding]; other site 290338007136 conserved gate region; other site 290338007137 putative PBP binding loops; other site 290338007138 ABC-ATPase subunit interface; other site 290338007139 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290338007140 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290338007141 Walker A/P-loop; other site 290338007142 ATP binding site [chemical binding]; other site 290338007143 Q-loop/lid; other site 290338007144 ABC transporter signature motif; other site 290338007145 Walker B; other site 290338007146 D-loop; other site 290338007147 H-loop/switch region; other site 290338007148 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 290338007149 active site 290338007150 tetramer interface [polypeptide binding]; other site 290338007151 hypothetical protein; Provisional; Region: PRK11032 290338007152 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290338007153 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290338007154 HIGH motif; other site 290338007155 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290338007156 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290338007157 active site 290338007158 KMSKS motif; other site 290338007159 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290338007160 tRNA binding surface [nucleotide binding]; other site 290338007161 Lipopolysaccharide-assembly; Region: LptE; cl01125 290338007162 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 290338007163 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 290338007164 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290338007165 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290338007166 active site 290338007167 (T/H)XGH motif; other site 290338007168 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 290338007169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338007170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338007171 homodimer interface [polypeptide binding]; other site 290338007172 catalytic residue [active] 290338007173 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290338007174 catalytic core [active] 290338007175 ribosome-associated protein; Provisional; Region: PRK11538 290338007176 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 290338007177 penicillin-binding protein 2; Provisional; Region: PRK10795 290338007178 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290338007179 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290338007180 cell wall shape-determining protein; Provisional; Region: PRK10794 290338007181 rare lipoprotein A; Provisional; Region: PRK10672 290338007182 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 290338007183 Sporulation related domain; Region: SPOR; pfam05036 290338007184 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 290338007185 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 290338007186 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 290338007187 hypothetical protein; Provisional; Region: PRK04998 290338007188 lipoate-protein ligase B; Provisional; Region: PRK14342 290338007189 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 290338007190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338007191 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 290338007192 substrate binding pocket [chemical binding]; other site 290338007193 dimerization interface [polypeptide binding]; other site 290338007194 lipoyl synthase; Provisional; Region: PRK05481 290338007195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338007196 FeS/SAM binding site; other site 290338007197 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 290338007198 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290338007199 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 290338007200 putative active site [active] 290338007201 catalytic triad [active] 290338007202 putative dimer interface [polypeptide binding]; other site 290338007203 chromosome condensation membrane protein; Provisional; Region: PRK14196 290338007204 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290338007205 DNA-binding site [nucleotide binding]; DNA binding site 290338007206 RNA-binding motif; other site 290338007207 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 290338007208 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 290338007209 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290338007210 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 290338007211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338007212 active site 290338007213 phosphorylation site [posttranslational modification] 290338007214 intermolecular recognition site; other site 290338007215 dimerization interface [polypeptide binding]; other site 290338007216 Transcriptional regulator; Region: CitT; pfam12431 290338007217 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 290338007218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338007219 putative active site [active] 290338007220 heme pocket [chemical binding]; other site 290338007221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338007222 ATP binding site [chemical binding]; other site 290338007223 Mg2+ binding site [ion binding]; other site 290338007224 G-X-G motif; other site 290338007225 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 290338007226 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 290338007227 putative active site [active] 290338007228 (T/H)XGH motif; other site 290338007229 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 290338007230 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290338007231 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 290338007232 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 290338007233 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 290338007234 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 290338007235 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338007236 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 290338007237 transmembrane helices; other site 290338007238 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 290338007239 B1 nucleotide binding pocket [chemical binding]; other site 290338007240 B2 nucleotide binding pocket [chemical binding]; other site 290338007241 CAS motifs; other site 290338007242 active site 290338007243 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 290338007244 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290338007245 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 290338007246 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 290338007247 catalytic residue [active] 290338007248 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 290338007249 catalytic residues [active] 290338007250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338007251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338007252 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 290338007253 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 290338007254 dimer interface [polypeptide binding]; other site 290338007255 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290338007256 catalytic triad [active] 290338007257 peroxidatic and resolving cysteines [active] 290338007258 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 290338007259 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 290338007260 dimerization domain [polypeptide binding]; other site 290338007261 dimer interface [polypeptide binding]; other site 290338007262 catalytic residues [active] 290338007263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338007264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338007265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338007266 dimerization interface [polypeptide binding]; other site 290338007267 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 290338007268 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290338007269 Active Sites [active] 290338007270 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 290338007271 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 290338007272 ParB-like nuclease domain; Region: ParBc; pfam02195 290338007273 methionine aminotransferase; Validated; Region: PRK09082 290338007274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338007275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338007276 homodimer interface [polypeptide binding]; other site 290338007277 catalytic residue [active] 290338007278 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 290338007279 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 290338007280 putative active site [active] 290338007281 metal binding site [ion binding]; metal-binding site 290338007282 Uncharacterized small protein [Function unknown]; Region: COG2879 290338007283 carbon starvation protein A; Provisional; Region: PRK15015 290338007284 Carbon starvation protein CstA; Region: CstA; pfam02554 290338007285 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290338007286 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290338007287 CoenzymeA binding site [chemical binding]; other site 290338007288 subunit interaction site [polypeptide binding]; other site 290338007289 PHB binding site; other site 290338007290 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 290338007291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338007292 NAD(P) binding site [chemical binding]; other site 290338007293 active site 290338007294 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 290338007295 hydrophobic substrate binding pocket; other site 290338007296 Isochorismatase family; Region: Isochorismatase; pfam00857 290338007297 active site 290338007298 conserved cis-peptide bond; other site 290338007299 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 290338007300 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 290338007301 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 290338007302 acyl-activating enzyme (AAE) consensus motif; other site 290338007303 active site 290338007304 AMP binding site [chemical binding]; other site 290338007305 substrate binding site [chemical binding]; other site 290338007306 isochorismate synthase EntC; Provisional; Region: PRK15016 290338007307 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290338007308 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290338007309 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290338007310 siderophore binding site; other site 290338007311 enterobactin exporter EntS; Provisional; Region: PRK10489 290338007312 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338007313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338007314 ABC-ATPase subunit interface; other site 290338007315 dimer interface [polypeptide binding]; other site 290338007316 putative PBP binding regions; other site 290338007317 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290338007318 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338007319 ABC-ATPase subunit interface; other site 290338007320 dimer interface [polypeptide binding]; other site 290338007321 putative PBP binding regions; other site 290338007322 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 290338007323 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338007324 Walker A/P-loop; other site 290338007325 ATP binding site [chemical binding]; other site 290338007326 Q-loop/lid; other site 290338007327 ABC transporter signature motif; other site 290338007328 Walker B; other site 290338007329 D-loop; other site 290338007330 H-loop/switch region; other site 290338007331 LPS O-antigen length regulator; Provisional; Region: PRK10381 290338007332 Chain length determinant protein; Region: Wzz; pfam02706 290338007333 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 290338007334 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 290338007335 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290338007336 acyl-activating enzyme (AAE) consensus motif; other site 290338007337 AMP binding site [chemical binding]; other site 290338007338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290338007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 290338007340 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 290338007341 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 290338007342 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290338007343 outer membrane receptor FepA; Provisional; Region: PRK13524 290338007344 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338007345 N-terminal plug; other site 290338007346 ligand-binding site [chemical binding]; other site 290338007347 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 290338007348 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 290338007349 choline transport protein BetT; Provisional; Region: PRK09928 290338007350 transcriptional regulator BetI; Validated; Region: PRK00767 290338007351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338007352 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290338007353 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 290338007354 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290338007355 NAD(P) binding site [chemical binding]; other site 290338007356 catalytic residues [active] 290338007357 choline dehydrogenase; Validated; Region: PRK02106 290338007358 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290338007359 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 290338007360 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290338007361 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 290338007362 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 290338007363 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 290338007364 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290338007365 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 290338007366 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338007367 N-terminal plug; other site 290338007368 ligand-binding site [chemical binding]; other site 290338007369 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 290338007370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338007371 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290338007372 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 290338007373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290338007374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338007375 hypothetical protein; Provisional; Region: PRK10250 290338007376 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 290338007377 dimer interface [polypeptide binding]; other site 290338007378 FMN binding site [chemical binding]; other site 290338007379 Helix-turn-helix domain; Region: HTH_31; pfam13560 290338007380 putative transporter; Provisional; Region: PRK10504 290338007381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007382 putative substrate translocation pore; other site 290338007383 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290338007384 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290338007385 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338007386 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338007387 DNA binding site [nucleotide binding] 290338007388 domain linker motif; other site 290338007389 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 290338007390 dimerization interface [polypeptide binding]; other site 290338007391 ligand binding site [chemical binding]; other site 290338007392 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290338007393 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338007394 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290338007395 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290338007396 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290338007397 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 290338007398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007399 putative substrate translocation pore; other site 290338007400 phenylalanine transporter; Provisional; Region: PRK10249 290338007401 PQQ-like domain; Region: PQQ_2; pfam13360 290338007402 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 290338007403 active site 290338007404 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 290338007405 PilZ domain; Region: PilZ; pfam07238 290338007406 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 290338007407 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 290338007408 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338007409 periplasmic copper-binding protein; Provisional; Region: PRK09838 290338007410 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 290338007411 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 290338007412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338007413 active site 290338007414 phosphorylation site [posttranslational modification] 290338007415 intermolecular recognition site; other site 290338007416 dimerization interface [polypeptide binding]; other site 290338007417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338007418 DNA binding site [nucleotide binding] 290338007419 sensor kinase CusS; Provisional; Region: PRK09835 290338007420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338007421 dimerization interface [polypeptide binding]; other site 290338007422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338007423 dimer interface [polypeptide binding]; other site 290338007424 phosphorylation site [posttranslational modification] 290338007425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338007426 ATP binding site [chemical binding]; other site 290338007427 Mg2+ binding site [ion binding]; other site 290338007428 G-X-G motif; other site 290338007429 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 290338007430 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338007431 dimerization interface [polypeptide binding]; other site 290338007432 DNA binding residues [nucleotide binding] 290338007433 EAL domain; Region: EAL; pfam00563 290338007434 transcriptional regulator FimZ; Provisional; Region: PRK09935 290338007435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338007436 active site 290338007437 phosphorylation site [posttranslational modification] 290338007438 intermolecular recognition site; other site 290338007439 dimerization interface [polypeptide binding]; other site 290338007440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338007441 DNA binding residues [nucleotide binding] 290338007442 dimerization interface [polypeptide binding]; other site 290338007443 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 290338007444 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 290338007445 outer membrane usher protein FimD; Provisional; Region: PRK15198 290338007446 PapC N-terminal domain; Region: PapC_N; pfam13954 290338007447 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338007448 PapC C-terminal domain; Region: PapC_C; pfam13953 290338007449 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 290338007450 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338007451 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338007452 fimbrial protein FimI; Provisional; Region: PRK15200 290338007453 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 290338007454 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 290338007455 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290338007456 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290338007457 homodimer interface [polypeptide binding]; other site 290338007458 NADP binding site [chemical binding]; other site 290338007459 substrate binding site [chemical binding]; other site 290338007460 ribosome-associated protein; Provisional; Region: PRK11507 290338007461 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290338007462 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290338007463 active site 290338007464 HIGH motif; other site 290338007465 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290338007466 KMSKS motif; other site 290338007467 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 290338007468 tRNA binding surface [nucleotide binding]; other site 290338007469 anticodon binding site; other site 290338007470 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14321 290338007471 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 290338007472 substrate binding site [chemical binding]; other site 290338007473 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 290338007474 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290338007475 putative active site [active] 290338007476 putative metal binding site [ion binding]; other site 290338007477 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 290338007478 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 290338007479 ATP-grasp domain; Region: ATP-grasp; pfam02222 290338007480 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 290338007481 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 290338007482 active site residue [active] 290338007483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338007484 dimer interface [polypeptide binding]; other site 290338007485 conserved gate region; other site 290338007486 ABC-ATPase subunit interface; other site 290338007487 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 290338007488 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290338007489 Walker A/P-loop; other site 290338007490 ATP binding site [chemical binding]; other site 290338007491 Q-loop/lid; other site 290338007492 ABC transporter signature motif; other site 290338007493 Walker B; other site 290338007494 D-loop; other site 290338007495 H-loop/switch region; other site 290338007496 NIL domain; Region: NIL; pfam09383 290338007497 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 290338007498 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 290338007499 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338007500 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338007501 eyelet of channel; other site 290338007502 trimer interface [polypeptide binding]; other site 290338007503 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 290338007504 FtsX-like permease family; Region: FtsX; pfam02687 290338007505 FtsX-like permease family; Region: FtsX; pfam02687 290338007506 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 290338007507 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290338007508 Walker A/P-loop; other site 290338007509 ATP binding site [chemical binding]; other site 290338007510 Q-loop/lid; other site 290338007511 ABC transporter signature motif; other site 290338007512 Walker B; other site 290338007513 D-loop; other site 290338007514 H-loop/switch region; other site 290338007515 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 290338007516 active site 290338007517 catalytic triad [active] 290338007518 oxyanion hole [active] 290338007519 switch loop; other site 290338007520 oxidoreductase; Provisional; Region: PRK08017 290338007521 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290338007522 NADP binding site [chemical binding]; other site 290338007523 active site 290338007524 steroid binding site; other site 290338007525 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 290338007526 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 290338007527 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 290338007528 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 290338007529 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 290338007530 Walker A/P-loop; other site 290338007531 ATP binding site [chemical binding]; other site 290338007532 Q-loop/lid; other site 290338007533 ABC transporter signature motif; other site 290338007534 Walker B; other site 290338007535 D-loop; other site 290338007536 H-loop/switch region; other site 290338007537 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 290338007538 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290338007539 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 290338007540 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 290338007541 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 290338007542 DNA binding residues [nucleotide binding] 290338007543 dimer interface [polypeptide binding]; other site 290338007544 copper binding site [ion binding]; other site 290338007545 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 290338007546 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338007547 N-terminal plug; other site 290338007548 ligand-binding site [chemical binding]; other site 290338007549 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 290338007550 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 290338007551 putative hemin binding site; other site 290338007552 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 290338007553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338007554 FeS/SAM binding site; other site 290338007555 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 290338007556 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290338007557 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290338007558 NAD(P) binding site [chemical binding]; other site 290338007559 putative active site [active] 290338007560 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338007561 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338007562 ABC-ATPase subunit interface; other site 290338007563 dimer interface [polypeptide binding]; other site 290338007564 putative PBP binding regions; other site 290338007565 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 290338007566 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338007567 Walker A/P-loop; other site 290338007568 ATP binding site [chemical binding]; other site 290338007569 Q-loop/lid; other site 290338007570 ABC transporter signature motif; other site 290338007571 Walker B; other site 290338007572 D-loop; other site 290338007573 H-loop/switch region; other site 290338007574 metabolite-proton symporter; Region: 2A0106; TIGR00883 290338007575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007576 putative substrate translocation pore; other site 290338007577 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338007578 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290338007579 ligand binding site [chemical binding]; other site 290338007580 dimerization interface [polypeptide binding]; other site 290338007581 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 290338007582 active site 290338007583 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 290338007584 MgtC family; Region: MgtC; pfam02308 290338007585 copper exporting ATPase; Provisional; Region: copA; PRK10671 290338007586 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290338007587 metal-binding site [ion binding] 290338007588 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290338007589 metal-binding site [ion binding] 290338007590 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290338007591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338007592 motif II; other site 290338007593 TraB family; Region: TraB; cl12050 290338007594 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 290338007595 putative deacylase active site [active] 290338007596 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 290338007597 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 290338007598 active site 290338007599 metal binding site [ion binding]; metal-binding site 290338007600 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290338007601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338007603 putative substrate translocation pore; other site 290338007604 putative cation:proton antiport protein; Provisional; Region: PRK10669 290338007605 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 290338007606 TrkA-N domain; Region: TrkA_N; pfam02254 290338007607 inosine/guanosine kinase; Provisional; Region: PRK15074 290338007608 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338007609 acetyl esterase; Provisional; Region: PRK10162 290338007610 ferrochelatase; Reviewed; Region: hemH; PRK00035 290338007611 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290338007612 C-terminal domain interface [polypeptide binding]; other site 290338007613 active site 290338007614 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290338007615 active site 290338007616 N-terminal domain interface [polypeptide binding]; other site 290338007617 adenylate kinase; Reviewed; Region: adk; PRK00279 290338007618 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290338007619 AMP-binding site [chemical binding]; other site 290338007620 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290338007621 heat shock protein 90; Provisional; Region: PRK05218 290338007622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338007623 ATP binding site [chemical binding]; other site 290338007624 Mg2+ binding site [ion binding]; other site 290338007625 G-X-G motif; other site 290338007626 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 290338007627 RecR protein; Region: RecR; pfam02132 290338007628 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290338007629 putative active site [active] 290338007630 putative metal-binding site [ion binding]; other site 290338007631 tetramer interface [polypeptide binding]; other site 290338007632 hypothetical protein; Validated; Region: PRK00153 290338007633 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 290338007634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338007635 Walker A motif; other site 290338007636 ATP binding site [chemical binding]; other site 290338007637 Walker B motif; other site 290338007638 DNA polymerase III subunit delta'; Validated; Region: PRK08485 290338007639 arginine finger; other site 290338007640 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 290338007641 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 290338007642 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 290338007643 DNAX ribosomal frameshifting element 290338007644 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338007645 active site 290338007646 hypothetical protein; Provisional; Region: PRK10527 290338007647 primosomal replication protein N''; Provisional; Region: PRK10093 290338007648 hypothetical protein; Provisional; Region: PRK11038 290338007649 putative transposase; Provisional; Region: PRK09857 290338007650 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 290338007651 hypothetical protein; Provisional; Region: PRK11281 290338007652 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 290338007653 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 290338007654 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290338007655 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 290338007656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338007657 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 290338007658 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 290338007659 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338007660 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 290338007661 Protein export membrane protein; Region: SecD_SecF; cl14618 290338007662 Protein export membrane protein; Region: SecD_SecF; cl14618 290338007663 Hha toxicity attenuator; Provisional; Region: PRK10667 290338007664 gene expression modulator; Provisional; Region: PRK10945 290338007665 maltose O-acetyltransferase; Provisional; Region: PRK10092 290338007666 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 290338007667 active site 290338007668 substrate binding site [chemical binding]; other site 290338007669 trimer interface [polypeptide binding]; other site 290338007670 CoA binding site [chemical binding]; other site 290338007671 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 290338007672 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 290338007673 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 290338007674 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290338007675 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290338007676 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338007677 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 290338007678 Predicted membrane protein [Function unknown]; Region: COG2364 290338007679 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 290338007680 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290338007681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338007682 DNA-binding site [nucleotide binding]; DNA binding site 290338007683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338007684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338007685 homodimer interface [polypeptide binding]; other site 290338007686 catalytic residue [active] 290338007687 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 290338007688 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290338007689 DNA binding site [nucleotide binding] 290338007690 active site 290338007691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 290338007692 acyl-CoA thioesterase II; Provisional; Region: PRK10526 290338007693 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290338007694 active site 290338007695 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290338007696 catalytic triad [active] 290338007697 dimer interface [polypeptide binding]; other site 290338007698 ammonium transporter; Provisional; Region: PRK10666 290338007699 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 290338007700 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290338007701 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 290338007702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338007703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338007704 Walker A/P-loop; other site 290338007705 ATP binding site [chemical binding]; other site 290338007706 Q-loop/lid; other site 290338007707 ABC transporter signature motif; other site 290338007708 Walker B; other site 290338007709 D-loop; other site 290338007710 H-loop/switch region; other site 290338007711 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 290338007712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290338007713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338007714 Walker A/P-loop; other site 290338007715 ATP binding site [chemical binding]; other site 290338007716 Q-loop/lid; other site 290338007717 ABC transporter signature motif; other site 290338007718 Walker B; other site 290338007719 D-loop; other site 290338007720 H-loop/switch region; other site 290338007721 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290338007722 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290338007723 AsnC family; Region: AsnC_trans_reg; pfam01037 290338007724 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290338007725 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290338007726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338007727 catalytic residue [active] 290338007728 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 290338007729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338007730 active site 290338007731 motif I; other site 290338007732 motif II; other site 290338007733 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290338007734 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 290338007735 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 290338007736 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 290338007737 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 290338007738 Ligand Binding Site [chemical binding]; other site 290338007739 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290338007740 active site 290338007741 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 290338007742 periplasmic folding chaperone; Provisional; Region: PRK10788 290338007743 SurA N-terminal domain; Region: SurA_N_3; cl07813 290338007744 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 290338007745 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290338007746 IHF dimer interface [polypeptide binding]; other site 290338007747 IHF - DNA interface [nucleotide binding]; other site 290338007748 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 290338007749 Found in ATP-dependent protease La (LON); Region: LON; smart00464 290338007750 Found in ATP-dependent protease La (LON); Region: LON; smart00464 290338007751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338007752 Walker A motif; other site 290338007753 ATP binding site [chemical binding]; other site 290338007754 Walker B motif; other site 290338007755 arginine finger; other site 290338007756 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290338007757 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290338007758 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 290338007759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338007760 Walker A motif; other site 290338007761 ATP binding site [chemical binding]; other site 290338007762 Walker B motif; other site 290338007763 Iron permease FTR1 family; Region: FTR1; cl00475 290338007764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290338007765 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 290338007766 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290338007767 oligomer interface [polypeptide binding]; other site 290338007768 active site residues [active] 290338007769 trigger factor; Provisional; Region: tig; PRK01490 290338007770 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290338007771 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290338007772 transcriptional regulator BolA; Provisional; Region: PRK11628 290338007773 hypothetical protein; Provisional; Region: PRK11627 290338007774 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 290338007775 muropeptide transporter; Reviewed; Region: ampG; PRK11902 290338007776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007777 putative substrate translocation pore; other site 290338007778 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 290338007779 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 290338007780 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 290338007781 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 290338007782 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 290338007783 D-pathway; other site 290338007784 Putative ubiquinol binding site [chemical binding]; other site 290338007785 Low-spin heme (heme b) binding site [chemical binding]; other site 290338007786 Putative water exit pathway; other site 290338007787 Binuclear center (heme o3/CuB) [ion binding]; other site 290338007788 K-pathway; other site 290338007789 Putative proton exit pathway; other site 290338007790 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 290338007791 Subunit I/III interface [polypeptide binding]; other site 290338007792 Subunit III/IV interface [polypeptide binding]; other site 290338007793 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 290338007794 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 290338007795 UbiA prenyltransferase family; Region: UbiA; pfam01040 290338007796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338007798 putative substrate translocation pore; other site 290338007799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 290338007800 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 290338007801 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 290338007802 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290338007803 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290338007804 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 290338007805 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 290338007806 conserved cys residue [active] 290338007807 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 290338007808 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 290338007809 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 290338007810 Ligand Binding Site [chemical binding]; other site 290338007811 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290338007812 active site residue [active] 290338007813 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 290338007814 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290338007815 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290338007816 substrate binding pocket [chemical binding]; other site 290338007817 chain length determination region; other site 290338007818 substrate-Mg2+ binding site; other site 290338007819 catalytic residues [active] 290338007820 aspartate-rich region 1; other site 290338007821 active site lid residues [active] 290338007822 aspartate-rich region 2; other site 290338007823 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 290338007824 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 290338007825 TPP-binding site; other site 290338007826 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290338007827 PYR/PP interface [polypeptide binding]; other site 290338007828 dimer interface [polypeptide binding]; other site 290338007829 TPP binding site [chemical binding]; other site 290338007830 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290338007831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338007832 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338007833 active site 290338007834 catalytic tetrad [active] 290338007835 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 290338007836 tetramer interfaces [polypeptide binding]; other site 290338007837 binuclear metal-binding site [ion binding]; other site 290338007838 thiamine monophosphate kinase; Provisional; Region: PRK05731 290338007839 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290338007840 ATP binding site [chemical binding]; other site 290338007841 dimerization interface [polypeptide binding]; other site 290338007842 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 290338007843 putative RNA binding site [nucleotide binding]; other site 290338007844 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290338007845 homopentamer interface [polypeptide binding]; other site 290338007846 active site 290338007847 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 290338007848 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290338007849 catalytic motif [active] 290338007850 Zn binding site [ion binding]; other site 290338007851 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 290338007852 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 290338007853 ATP cone domain; Region: ATP-cone; pfam03477 290338007854 hypothetical protein; Provisional; Region: PRK11530 290338007855 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 290338007856 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290338007857 active site 290338007858 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 290338007859 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290338007860 Protein export membrane protein; Region: SecD_SecF; pfam02355 290338007861 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 290338007862 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 290338007863 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290338007864 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 290338007865 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 290338007866 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 290338007867 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 290338007868 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 290338007869 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 290338007870 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 290338007871 peroxidase; Provisional; Region: PRK15000 290338007872 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 290338007873 dimer interface [polypeptide binding]; other site 290338007874 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290338007875 catalytic triad [active] 290338007876 peroxidatic and resolving cysteines [active] 290338007877 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 290338007878 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 290338007879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338007880 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 290338007881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338007882 dimerization interface [polypeptide binding]; other site 290338007883 maltodextrin glucosidase; Provisional; Region: PRK10785 290338007884 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 290338007885 homodimer interface [polypeptide binding]; other site 290338007886 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 290338007887 active site 290338007888 homodimer interface [polypeptide binding]; other site 290338007889 catalytic site [active] 290338007890 putative proline-specific permease; Provisional; Region: proY; PRK10580 290338007891 Spore germination protein; Region: Spore_permease; cl17796 290338007892 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 290338007893 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 290338007894 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 290338007895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338007896 putative active site [active] 290338007897 heme pocket [chemical binding]; other site 290338007898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338007899 dimer interface [polypeptide binding]; other site 290338007900 phosphorylation site [posttranslational modification] 290338007901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338007902 ATP binding site [chemical binding]; other site 290338007903 Mg2+ binding site [ion binding]; other site 290338007904 G-X-G motif; other site 290338007905 transcriptional regulator PhoB; Provisional; Region: PRK10161 290338007906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338007907 active site 290338007908 phosphorylation site [posttranslational modification] 290338007909 intermolecular recognition site; other site 290338007910 dimerization interface [polypeptide binding]; other site 290338007911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338007912 DNA binding site [nucleotide binding] 290338007913 exonuclease subunit SbcD; Provisional; Region: PRK10966 290338007914 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290338007915 active site 290338007916 metal binding site [ion binding]; metal-binding site 290338007917 DNA binding site [nucleotide binding] 290338007918 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290338007919 exonuclease subunit SbcC; Provisional; Region: PRK10246 290338007920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338007921 Walker A/P-loop; other site 290338007922 ATP binding site [chemical binding]; other site 290338007923 Q-loop/lid; other site 290338007924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338007925 ABC transporter signature motif; other site 290338007926 Walker B; other site 290338007927 D-loop; other site 290338007928 H-loop/switch region; other site 290338007929 fructokinase; Reviewed; Region: PRK09557 290338007930 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338007931 nucleotide binding site [chemical binding]; other site 290338007932 recombination associated protein; Reviewed; Region: rdgC; PRK00321 290338007933 hypothetical protein; Provisional; Region: PRK10579 290338007934 hypothetical protein; Provisional; Region: PRK10481 290338007935 hypothetical protein; Provisional; Region: PRK10380 290338007936 Shikimate kinase; Region: SKI; pfam01202 290338007937 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290338007938 magnesium binding site [ion binding]; other site 290338007939 putative shikimate binding site; other site 290338007940 hypothetical protein; Validated; Region: PRK00124 290338007941 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 290338007942 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 290338007943 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 290338007944 MASE2 domain; Region: MASE2; pfam05230 290338007945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338007946 metal binding site [ion binding]; metal-binding site 290338007947 active site 290338007948 I-site; other site 290338007949 hypothetical protein; Provisional; Region: PRK11505 290338007950 psiF repeat; Region: PsiF_repeat; pfam07769 290338007951 psiF repeat; Region: PsiF_repeat; pfam07769 290338007952 alkaline phosphatase; Provisional; Region: PRK10518 290338007953 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 290338007954 dimer interface [polypeptide binding]; other site 290338007955 active site 290338007956 anti-RssB factor; Provisional; Region: PRK10244 290338007957 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 290338007958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338007959 DNA binding site [nucleotide binding] 290338007960 domain linker motif; other site 290338007961 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 290338007962 putative dimerization interface [polypeptide binding]; other site 290338007963 putative ligand binding site [chemical binding]; other site 290338007964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007965 D-galactonate transporter; Region: 2A0114; TIGR00893 290338007966 putative substrate translocation pore; other site 290338007967 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 290338007968 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290338007969 NADP binding site [chemical binding]; other site 290338007970 homodimer interface [polypeptide binding]; other site 290338007971 active site 290338007972 drug efflux system protein MdtG; Provisional; Region: PRK09874 290338007973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338007974 putative substrate translocation pore; other site 290338007975 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 290338007976 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290338007977 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290338007978 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 290338007979 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 290338007980 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 290338007981 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 290338007982 microcin B17 transporter; Reviewed; Region: PRK11098 290338007983 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 290338007984 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290338007985 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 290338007986 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 290338007987 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 290338007988 Autotransporter beta-domain; Region: Autotransporter; pfam03797 290338007989 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 290338007990 dimer interface [polypeptide binding]; other site 290338007991 active site 290338007992 Schiff base residues; other site 290338007993 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 290338007994 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290338007995 putative acyl-acceptor binding pocket; other site 290338007996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 290338007997 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 290338007998 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 290338007999 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290338008000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338008001 dimer interface [polypeptide binding]; other site 290338008002 conserved gate region; other site 290338008003 putative PBP binding loops; other site 290338008004 ABC-ATPase subunit interface; other site 290338008005 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 290338008006 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290338008007 Walker A/P-loop; other site 290338008008 ATP binding site [chemical binding]; other site 290338008009 Q-loop/lid; other site 290338008010 ABC transporter signature motif; other site 290338008011 Walker B; other site 290338008012 D-loop; other site 290338008013 H-loop/switch region; other site 290338008014 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 290338008015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338008016 substrate binding pocket [chemical binding]; other site 290338008017 membrane-bound complex binding site; other site 290338008018 hinge residues; other site 290338008019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338008020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338008021 active site 290338008022 phosphorylation site [posttranslational modification] 290338008023 intermolecular recognition site; other site 290338008024 dimerization interface [polypeptide binding]; other site 290338008025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338008026 DNA binding residues [nucleotide binding] 290338008027 dimerization interface [polypeptide binding]; other site 290338008028 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 290338008029 MASE1; Region: MASE1; pfam05231 290338008030 Histidine kinase; Region: HisKA_3; pfam07730 290338008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338008032 ATP binding site [chemical binding]; other site 290338008033 Mg2+ binding site [ion binding]; other site 290338008034 G-X-G motif; other site 290338008035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338008036 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 290338008037 putative substrate translocation pore; other site 290338008038 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 290338008039 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290338008040 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290338008041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338008042 dimer interface [polypeptide binding]; other site 290338008043 conserved gate region; other site 290338008044 putative PBP binding loops; other site 290338008045 ABC-ATPase subunit interface; other site 290338008046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338008047 dimer interface [polypeptide binding]; other site 290338008048 conserved gate region; other site 290338008049 putative PBP binding loops; other site 290338008050 ABC-ATPase subunit interface; other site 290338008051 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 290338008052 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 290338008053 Walker A/P-loop; other site 290338008054 ATP binding site [chemical binding]; other site 290338008055 Q-loop/lid; other site 290338008056 ABC transporter signature motif; other site 290338008057 Walker B; other site 290338008058 D-loop; other site 290338008059 H-loop/switch region; other site 290338008060 TOBE domain; Region: TOBE_2; pfam08402 290338008061 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 290338008062 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 290338008063 lac repressor; Reviewed; Region: lacI; PRK09526 290338008064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338008065 DNA binding site [nucleotide binding] 290338008066 domain linker motif; other site 290338008067 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290338008068 ligand binding site [chemical binding]; other site 290338008069 dimerization interface (open form) [polypeptide binding]; other site 290338008070 dimerization interface (closed form) [polypeptide binding]; other site 290338008071 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 290338008072 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 290338008073 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 290338008074 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 290338008075 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 290338008076 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 290338008077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338008078 acyl-activating enzyme (AAE) consensus motif; other site 290338008079 AMP binding site [chemical binding]; other site 290338008080 active site 290338008081 CoA binding site [chemical binding]; other site 290338008082 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 290338008083 2-methylcitrate dehydratase; Region: prpD; TIGR02330 290338008084 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 290338008085 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 290338008086 dimer interface [polypeptide binding]; other site 290338008087 active site 290338008088 citrylCoA binding site [chemical binding]; other site 290338008089 oxalacetate/citrate binding site [chemical binding]; other site 290338008090 coenzyme A binding site [chemical binding]; other site 290338008091 catalytic triad [active] 290338008092 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290338008093 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290338008094 tetramer interface [polypeptide binding]; other site 290338008095 active site 290338008096 Mg2+/Mn2+ binding site [ion binding]; other site 290338008097 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 290338008098 Propionate catabolism activator; Region: PrpR_N; pfam06506 290338008099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338008100 Walker A motif; other site 290338008101 ATP binding site [chemical binding]; other site 290338008102 Walker B motif; other site 290338008103 arginine finger; other site 290338008104 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338008105 hypothetical protein; Provisional; Region: PRK09929 290338008106 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 290338008107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338008108 putative substrate translocation pore; other site 290338008109 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290338008110 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 290338008111 Protein export membrane protein; Region: SecD_SecF; cl14618 290338008112 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 290338008113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338008114 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338008115 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 290338008116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338008117 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290338008118 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290338008119 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338008120 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338008121 putative active site [active] 290338008122 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290338008123 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290338008124 siderophore binding site; other site 290338008125 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 290338008126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338008127 ABC-ATPase subunit interface; other site 290338008128 dimer interface [polypeptide binding]; other site 290338008129 putative PBP binding regions; other site 290338008130 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338008131 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338008132 ABC-ATPase subunit interface; other site 290338008133 dimer interface [polypeptide binding]; other site 290338008134 putative PBP binding regions; other site 290338008135 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290338008136 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338008137 Walker A/P-loop; other site 290338008138 ATP binding site [chemical binding]; other site 290338008139 Q-loop/lid; other site 290338008140 ABC transporter signature motif; other site 290338008141 Walker B; other site 290338008142 D-loop; other site 290338008143 H-loop/switch region; other site 290338008144 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338008145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338008146 N-terminal plug; other site 290338008147 ligand-binding site [chemical binding]; other site 290338008148 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 290338008149 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 290338008150 substrate binding site [chemical binding]; other site 290338008151 tetramer interface [polypeptide binding]; other site 290338008152 catalytic residue [active] 290338008153 tryptophan permease; Provisional; Region: PRK10483 290338008154 aromatic amino acid transport protein; Region: araaP; TIGR00837 290338008155 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 290338008156 Mg binding site [ion binding]; other site 290338008157 nucleotide binding site [chemical binding]; other site 290338008158 putative protofilament interface [polypeptide binding]; other site 290338008159 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290338008160 NlpC/P60 family; Region: NLPC_P60; pfam00877 290338008161 hypothetical protein; Validated; Region: PRK06778 290338008162 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 290338008163 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290338008164 ligand binding site [chemical binding]; other site 290338008165 flagellar motor protein MotA; Provisional; Region: PRK12482 290338008166 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 290338008167 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 290338008168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338008169 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290338008170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290338008171 DNA binding residues [nucleotide binding] 290338008172 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 290338008173 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 290338008174 Flagellar protein FliS; Region: FliS; cl00654 290338008175 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 290338008176 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 290338008177 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 290338008178 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290338008179 flagellin; Provisional; Region: PRK12804 290338008180 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 290338008181 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290338008182 flagellin; Provisional; Region: PRK12804 290338008183 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 290338008184 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 290338008185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290338008186 DNA binding site [nucleotide binding] 290338008187 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 290338008188 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 290338008189 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 290338008190 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338008191 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 290338008192 peptidoglycan hydrolase; Reviewed; Region: flgJ; PRK12708 290338008193 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 290338008194 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 290338008195 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 290338008196 Flagellar L-ring protein; Region: FlgH; pfam02107 290338008197 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 290338008198 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338008199 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290338008200 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 290338008201 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338008202 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 290338008203 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 290338008204 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338008205 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 290338008206 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 290338008207 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290338008208 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 290338008209 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 290338008210 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 290338008211 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 290338008212 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 290338008213 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 290338008214 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 290338008215 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 290338008216 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 290338008217 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290338008218 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 290338008219 FlgN protein; Region: FlgN; pfam05130 290338008220 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290338008221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338008222 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290338008223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290338008224 active site 290338008225 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290338008226 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290338008227 putative active site [active] 290338008228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290338008229 active site 290338008230 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 290338008231 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 290338008232 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 290338008233 Walker A motif/ATP binding site; other site 290338008234 Walker B motif; other site 290338008235 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 290338008236 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 290338008237 Flagellar assembly protein FliH; Region: FliH; pfam02108 290338008238 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 290338008239 MgtE intracellular N domain; Region: MgtE_N; smart00924 290338008240 FliG C-terminal domain; Region: FliG_C; pfam01706 290338008241 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 290338008242 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 290338008243 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 290338008244 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 290338008245 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 290338008246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338008247 Walker A motif; other site 290338008248 ATP binding site [chemical binding]; other site 290338008249 Walker B motif; other site 290338008250 arginine finger; other site 290338008251 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338008252 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 290338008253 flagellar motor switch protein FliN; Region: fliN; TIGR02480 290338008254 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 290338008255 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 290338008256 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 290338008257 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 290338008258 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 290338008259 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 290338008260 FHIPEP family; Region: FHIPEP; pfam00771 290338008261 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 290338008262 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290338008263 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290338008264 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338008265 anti-adapter protein IraM; Provisional; Region: PRK09919 290338008266 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338008267 Helix-turn-helix domain; Region: HTH_18; pfam12833 290338008268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338008269 SnoaL-like domain; Region: SnoaL_2; pfam12680 290338008270 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338008271 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338008272 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338008273 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338008274 PapC N-terminal domain; Region: PapC_N; pfam13954 290338008275 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338008276 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338008277 PapC C-terminal domain; Region: PapC_C; pfam13953 290338008278 Fimbrial protein; Region: Fimbrial; pfam00419 290338008279 EAL domain; Region: EAL; pfam00563 290338008280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 290338008281 DNA binding residues [nucleotide binding] 290338008282 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290338008283 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 290338008284 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290338008285 active sites [active] 290338008286 tetramer interface [polypeptide binding]; other site 290338008287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338008288 dimer interface [polypeptide binding]; other site 290338008289 conserved gate region; other site 290338008290 ABC-ATPase subunit interface; other site 290338008291 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 290338008292 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290338008293 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290338008294 Walker A/P-loop; other site 290338008295 ATP binding site [chemical binding]; other site 290338008296 Q-loop/lid; other site 290338008297 ABC transporter signature motif; other site 290338008298 Walker B; other site 290338008299 D-loop; other site 290338008300 H-loop/switch region; other site 290338008301 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 290338008302 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 290338008303 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 290338008304 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 290338008305 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 290338008306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338008307 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 290338008308 dimerization interface [polypeptide binding]; other site 290338008309 substrate binding pocket [chemical binding]; other site 290338008310 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338008311 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290338008312 TM-ABC transporter signature motif; other site 290338008313 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 290338008314 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290338008315 TM-ABC transporter signature motif; other site 290338008316 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 290338008317 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290338008318 Walker A/P-loop; other site 290338008319 ATP binding site [chemical binding]; other site 290338008320 Q-loop/lid; other site 290338008321 ABC transporter signature motif; other site 290338008322 Walker B; other site 290338008323 D-loop; other site 290338008324 H-loop/switch region; other site 290338008325 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 290338008326 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290338008327 Walker A/P-loop; other site 290338008328 ATP binding site [chemical binding]; other site 290338008329 Q-loop/lid; other site 290338008330 ABC transporter signature motif; other site 290338008331 Walker B; other site 290338008332 D-loop; other site 290338008333 H-loop/switch region; other site 290338008334 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290338008335 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 290338008336 dimerization interface [polypeptide binding]; other site 290338008337 ligand binding site [chemical binding]; other site 290338008338 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 290338008339 allantoate amidohydrolase; Reviewed; Region: PRK12893 290338008340 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 290338008341 active site 290338008342 metal binding site [ion binding]; metal-binding site 290338008343 dimer interface [polypeptide binding]; other site 290338008344 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 290338008345 methionine synthase; Provisional; Region: PRK01207 290338008346 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290338008347 substrate binding site [chemical binding]; other site 290338008348 THF binding site; other site 290338008349 zinc-binding site [ion binding]; other site 290338008350 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290338008351 putative binding surface; other site 290338008352 active site 290338008353 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 290338008354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338008355 DNA binding site [nucleotide binding] 290338008356 domain linker motif; other site 290338008357 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 290338008358 dimerization interface [polypeptide binding]; other site 290338008359 ligand binding site [chemical binding]; other site 290338008360 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 290338008361 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290338008362 substrate binding [chemical binding]; other site 290338008363 active site 290338008364 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290338008365 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 290338008366 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338008367 active site turn [active] 290338008368 phosphorylation site [posttranslational modification] 290338008369 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290338008370 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 290338008371 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 290338008372 trimer interface; other site 290338008373 sugar binding site [chemical binding]; other site 290338008374 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338008375 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290338008376 putative substrate binding site [chemical binding]; other site 290338008377 putative ATP binding site [chemical binding]; other site 290338008378 Y-family of DNA polymerases; Region: PolY; cl12025 290338008379 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290338008380 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290338008381 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290338008382 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290338008383 putative catalytic cysteine [active] 290338008384 gamma-glutamyl kinase; Provisional; Region: PRK05429 290338008385 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290338008386 nucleotide binding site [chemical binding]; other site 290338008387 homotetrameric interface [polypeptide binding]; other site 290338008388 putative phosphate binding site [ion binding]; other site 290338008389 putative allosteric binding site; other site 290338008390 PUA domain; Region: PUA; pfam01472 290338008391 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338008392 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338008393 trimer interface [polypeptide binding]; other site 290338008394 eyelet of channel; other site 290338008395 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 290338008396 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 290338008397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338008398 active site 290338008399 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 290338008400 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 290338008401 metal binding site [ion binding]; metal-binding site 290338008402 dimer interface [polypeptide binding]; other site 290338008403 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290338008404 active site 290338008405 DNA polymerase IV; Validated; Region: PRK02406 290338008406 DNA binding site [nucleotide binding] 290338008407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 290338008408 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290338008409 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 290338008410 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 290338008411 putative active site [active] 290338008412 putative dimer interface [polypeptide binding]; other site 290338008413 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290338008414 dimer interface [polypeptide binding]; other site 290338008415 active site 290338008416 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 290338008417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290338008418 active site 290338008419 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 290338008420 C-N hydrolase family amidase; Provisional; Region: PRK10438 290338008421 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 290338008422 putative active site [active] 290338008423 catalytic triad [active] 290338008424 dimer interface [polypeptide binding]; other site 290338008425 multimer interface [polypeptide binding]; other site 290338008426 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 290338008427 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 290338008428 active site 290338008429 catalytic site [active] 290338008430 substrate binding site [chemical binding]; other site 290338008431 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290338008432 RNA/DNA hybrid binding site [nucleotide binding]; other site 290338008433 active site 290338008434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338008435 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 290338008436 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 290338008437 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338008438 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338008439 catalytic residue [active] 290338008440 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338008441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338008442 hypothetical protein; Provisional; Region: PRK08317 290338008443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338008444 S-adenosylmethionine binding site [chemical binding]; other site 290338008445 hypothetical protein; Provisional; Region: PRK05421 290338008446 putative catalytic site [active] 290338008447 putative metal binding site [ion binding]; other site 290338008448 putative phosphate binding site [ion binding]; other site 290338008449 putative catalytic site [active] 290338008450 putative phosphate binding site [ion binding]; other site 290338008451 putative metal binding site [ion binding]; other site 290338008452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338008453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338008454 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 290338008455 putative effector binding pocket; other site 290338008456 dimerization interface [polypeptide binding]; other site 290338008457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338008458 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338008459 active site 290338008460 catalytic tetrad [active] 290338008461 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290338008462 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290338008463 purine monophosphate binding site [chemical binding]; other site 290338008464 dimer interface [polypeptide binding]; other site 290338008465 putative catalytic residues [active] 290338008466 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 290338008467 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 290338008468 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290338008469 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290338008470 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 290338008471 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290338008472 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 290338008473 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290338008474 IHF dimer interface [polypeptide binding]; other site 290338008475 IHF - DNA interface [nucleotide binding]; other site 290338008476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 290338008477 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 290338008478 Active_site [active] 290338008479 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290338008480 substrate binding site [chemical binding]; other site 290338008481 active site 290338008482 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 290338008483 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 290338008484 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 290338008485 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 290338008486 putative NADH binding site [chemical binding]; other site 290338008487 putative active site [active] 290338008488 nudix motif; other site 290338008489 putative metal binding site [ion binding]; other site 290338008490 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 290338008491 TPP riboswitch (THI element) 290338008492 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290338008493 ThiC-associated domain; Region: ThiC-associated; pfam13667 290338008494 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 290338008495 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290338008496 thiamine phosphate binding site [chemical binding]; other site 290338008497 active site 290338008498 pyrophosphate binding site [ion binding]; other site 290338008499 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290338008500 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 290338008501 ATP binding site [chemical binding]; other site 290338008502 substrate interface [chemical binding]; other site 290338008503 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290338008504 thiS-thiF/thiG interaction site; other site 290338008505 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290338008506 ThiS interaction site; other site 290338008507 putative active site [active] 290338008508 tetramer interface [polypeptide binding]; other site 290338008509 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 290338008510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338008511 FeS/SAM binding site; other site 290338008512 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 290338008513 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 290338008514 active site 290338008515 P-loop; other site 290338008516 phosphorylation site [posttranslational modification] 290338008517 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 290338008518 active site 290338008519 methionine cluster; other site 290338008520 phosphorylation site [posttranslational modification] 290338008521 metal binding site [ion binding]; metal-binding site 290338008522 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290338008523 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 290338008524 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 290338008525 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290338008526 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290338008527 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 290338008528 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290338008529 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290338008530 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290338008531 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290338008532 DNA binding site [nucleotide binding] 290338008533 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290338008534 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 290338008535 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290338008536 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 290338008537 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290338008538 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 290338008539 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290338008540 RPB3 interaction site [polypeptide binding]; other site 290338008541 RPB1 interaction site [polypeptide binding]; other site 290338008542 RPB11 interaction site [polypeptide binding]; other site 290338008543 RPB10 interaction site [polypeptide binding]; other site 290338008544 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290338008545 core dimer interface [polypeptide binding]; other site 290338008546 peripheral dimer interface [polypeptide binding]; other site 290338008547 L10 interface [polypeptide binding]; other site 290338008548 L11 interface [polypeptide binding]; other site 290338008549 putative EF-Tu interaction site [polypeptide binding]; other site 290338008550 putative EF-G interaction site [polypeptide binding]; other site 290338008551 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290338008552 23S rRNA interface [nucleotide binding]; other site 290338008553 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 290338008554 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290338008555 mRNA/rRNA interface [nucleotide binding]; other site 290338008556 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290338008557 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290338008558 23S rRNA interface [nucleotide binding]; other site 290338008559 L7/L12 interface [polypeptide binding]; other site 290338008560 putative thiostrepton binding site; other site 290338008561 L25 interface [polypeptide binding]; other site 290338008562 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290338008563 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290338008564 putative homodimer interface [polypeptide binding]; other site 290338008565 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 290338008566 heterodimer interface [polypeptide binding]; other site 290338008567 homodimer interface [polypeptide binding]; other site 290338008568 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 290338008569 elongation factor Tu; Reviewed; Region: PRK00049 290338008570 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290338008571 G1 box; other site 290338008572 GEF interaction site [polypeptide binding]; other site 290338008573 GTP/Mg2+ binding site [chemical binding]; other site 290338008574 Switch I region; other site 290338008575 G2 box; other site 290338008576 G3 box; other site 290338008577 Switch II region; other site 290338008578 G4 box; other site 290338008579 G5 box; other site 290338008580 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290338008581 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290338008582 Antibiotic Binding Site [chemical binding]; other site 290338008583 pantothenate kinase; Provisional; Region: PRK05439 290338008584 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 290338008585 ATP-binding site [chemical binding]; other site 290338008586 CoA-binding site [chemical binding]; other site 290338008587 Mg2+-binding site [ion binding]; other site 290338008588 Biotin operon repressor [Transcription]; Region: BirA; COG1654 290338008589 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 290338008590 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 290338008591 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 290338008592 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 290338008593 FAD binding domain; Region: FAD_binding_4; pfam01565 290338008594 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 290338008595 glutamate racemase; Provisional; Region: PRK00865 290338008596 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 290338008597 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338008598 N-terminal plug; other site 290338008599 ligand-binding site [chemical binding]; other site 290338008600 cobalamin riboswitch 290338008601 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 290338008602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338008603 S-adenosylmethionine binding site [chemical binding]; other site 290338008604 hypothetical protein; Provisional; Region: PRK11056 290338008605 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 290338008606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338008607 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 290338008608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338008609 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290338008610 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 290338008611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338008612 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 290338008613 dimerization interface [polypeptide binding]; other site 290338008614 argininosuccinate lyase; Provisional; Region: PRK04833 290338008615 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290338008616 active sites [active] 290338008617 tetramer interface [polypeptide binding]; other site 290338008618 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 290338008619 nucleotide binding site [chemical binding]; other site 290338008620 N-acetyl-L-glutamate binding site [chemical binding]; other site 290338008621 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290338008622 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290338008623 acetylornithine deacetylase; Provisional; Region: PRK05111 290338008624 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 290338008625 metal binding site [ion binding]; metal-binding site 290338008626 putative dimer interface [polypeptide binding]; other site 290338008627 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 290338008628 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290338008629 hypothetical protein; Provisional; Region: PRK10649 290338008630 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 290338008631 Sulfatase; Region: Sulfatase; pfam00884 290338008632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338008633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338008634 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290338008635 active site 290338008636 P-loop; other site 290338008637 phosphorylation site [posttranslational modification] 290338008638 pyruvate formate lyase II activase; Provisional; Region: PRK10076 290338008639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338008640 FeS/SAM binding site; other site 290338008641 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 290338008642 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 290338008643 dimer interface [polypeptide binding]; other site 290338008644 active site 290338008645 glycine loop; other site 290338008646 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290338008647 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 290338008648 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 290338008649 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290338008650 dimerization domain swap beta strand [polypeptide binding]; other site 290338008651 regulatory protein interface [polypeptide binding]; other site 290338008652 active site 290338008653 regulatory phosphorylation site [posttranslational modification]; other site 290338008654 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290338008655 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 290338008656 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290338008657 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290338008658 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338008659 active site 290338008660 phosphorylation site [posttranslational modification] 290338008661 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 290338008662 active site 290338008663 intersubunit interactions; other site 290338008664 catalytic residue [active] 290338008665 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 290338008666 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 290338008667 dimer interface [polypeptide binding]; other site 290338008668 active site 290338008669 metal binding site [ion binding]; metal-binding site 290338008670 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 290338008671 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 290338008672 heme binding site [chemical binding]; other site 290338008673 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 290338008674 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 290338008675 FAD binding site [chemical binding]; other site 290338008676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338008677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338008678 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 290338008679 dimerization interface [polypeptide binding]; other site 290338008680 substrate binding pocket [chemical binding]; other site 290338008681 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 290338008682 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 290338008683 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 290338008684 putative catalytic residues [active] 290338008685 putative nucleotide binding site [chemical binding]; other site 290338008686 putative aspartate binding site [chemical binding]; other site 290338008687 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 290338008688 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290338008689 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290338008690 cystathionine gamma-synthase; Provisional; Region: PRK08045 290338008691 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290338008692 homodimer interface [polypeptide binding]; other site 290338008693 substrate-cofactor binding pocket; other site 290338008694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338008695 catalytic residue [active] 290338008696 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 290338008697 dimerization interface [polypeptide binding]; other site 290338008698 DNA binding site [nucleotide binding] 290338008699 corepressor binding sites; other site 290338008700 primosome assembly protein PriA; Validated; Region: PRK05580 290338008701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338008702 ATP binding site [chemical binding]; other site 290338008703 putative Mg++ binding site [ion binding]; other site 290338008704 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290338008705 ATP-binding site [chemical binding]; other site 290338008706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338008707 DNA binding site [nucleotide binding] 290338008708 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 290338008709 domain linker motif; other site 290338008710 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 290338008711 dimerization interface [polypeptide binding]; other site 290338008712 ligand binding site [chemical binding]; other site 290338008713 cell division protein FtsN; Provisional; Region: PRK12757 290338008714 Sporulation related domain; Region: SPOR; cl10051 290338008715 Sporulation related domain; Region: SPOR; cl10051 290338008716 cell division protein FtsN; Provisional; Region: PRK12757 290338008717 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 290338008718 active site 290338008719 HslU subunit interaction site [polypeptide binding]; other site 290338008720 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 290338008721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338008722 Walker A motif; other site 290338008723 ATP binding site [chemical binding]; other site 290338008724 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 290338008725 Walker B motif; other site 290338008726 arginine finger; other site 290338008727 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290338008728 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 290338008729 UbiA prenyltransferase family; Region: UbiA; pfam01040 290338008730 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 290338008731 septal ring assembly protein ZapB; Provisional; Region: PRK15422 290338008732 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290338008733 amphipathic channel; other site 290338008734 Asn-Pro-Ala signature motifs; other site 290338008735 glycerol kinase; Provisional; Region: glpK; PRK00047 290338008736 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 290338008737 N- and C-terminal domain interface [polypeptide binding]; other site 290338008738 active site 290338008739 MgATP binding site [chemical binding]; other site 290338008740 catalytic site [active] 290338008741 metal binding site [ion binding]; metal-binding site 290338008742 glycerol binding site [chemical binding]; other site 290338008743 homotetramer interface [polypeptide binding]; other site 290338008744 homodimer interface [polypeptide binding]; other site 290338008745 FBP binding site [chemical binding]; other site 290338008746 protein IIAGlc interface [polypeptide binding]; other site 290338008747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338008748 non-specific DNA binding site [nucleotide binding]; other site 290338008749 salt bridge; other site 290338008750 sequence-specific DNA binding site [nucleotide binding]; other site 290338008751 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 290338008752 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 290338008753 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 290338008754 putative active site [active] 290338008755 ferredoxin-NADP reductase; Provisional; Region: PRK10926 290338008756 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 290338008757 FAD binding pocket [chemical binding]; other site 290338008758 FAD binding motif [chemical binding]; other site 290338008759 phosphate binding motif [ion binding]; other site 290338008760 beta-alpha-beta structure motif; other site 290338008761 NAD binding pocket [chemical binding]; other site 290338008762 Predicted membrane protein [Function unknown]; Region: COG3152 290338008763 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 290338008764 triosephosphate isomerase; Provisional; Region: PRK14567 290338008765 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290338008766 substrate binding site [chemical binding]; other site 290338008767 dimer interface [polypeptide binding]; other site 290338008768 catalytic triad [active] 290338008769 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338008770 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 290338008771 transmembrane helices; other site 290338008772 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 290338008773 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290338008774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338008775 substrate binding pocket [chemical binding]; other site 290338008776 membrane-bound complex binding site; other site 290338008777 hinge residues; other site 290338008778 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 290338008779 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 290338008780 active site 290338008781 ADP/pyrophosphate binding site [chemical binding]; other site 290338008782 dimerization interface [polypeptide binding]; other site 290338008783 allosteric effector site; other site 290338008784 fructose-1,6-bisphosphate binding site; other site 290338008785 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 290338008786 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290338008787 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 290338008788 dimer interface [polypeptide binding]; other site 290338008789 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 290338008790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338008791 active site 290338008792 intermolecular recognition site; other site 290338008793 dimerization interface [polypeptide binding]; other site 290338008794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338008795 DNA binding site [nucleotide binding] 290338008796 two-component sensor protein; Provisional; Region: cpxA; PRK09470 290338008797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338008798 dimerization interface [polypeptide binding]; other site 290338008799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338008800 dimer interface [polypeptide binding]; other site 290338008801 phosphorylation site [posttranslational modification] 290338008802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338008803 ATP binding site [chemical binding]; other site 290338008804 Mg2+ binding site [ion binding]; other site 290338008805 G-X-G motif; other site 290338008806 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 290338008807 MOSC domain; Region: MOSC; pfam03473 290338008808 3-alpha domain; Region: 3-alpha; pfam03475 290338008809 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290338008810 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290338008811 active site 290338008812 inhibitor site; inhibition site 290338008813 dimer interface [polypeptide binding]; other site 290338008814 catalytic residue [active] 290338008815 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 290338008816 superoxide dismutase; Provisional; Region: PRK10925 290338008817 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290338008818 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290338008819 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 290338008820 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 290338008821 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338008822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338008823 transcriptional activator RhaS; Provisional; Region: PRK13503 290338008824 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338008825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338008826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338008827 rhamnulokinase; Provisional; Region: rhaB; PRK10640 290338008828 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 290338008829 N- and C-terminal domain interface [polypeptide binding]; other site 290338008830 active site 290338008831 carbohydrate binding site [chemical binding]; other site 290338008832 ATP binding site [chemical binding]; other site 290338008833 L-rhamnose isomerase; Provisional; Region: PRK01076 290338008834 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290338008835 intersubunit interface [polypeptide binding]; other site 290338008836 active site 290338008837 Zn2+ binding site [ion binding]; other site 290338008838 lactaldehyde reductase; Region: lactal_redase; TIGR02638 290338008839 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 290338008840 dimer interface [polypeptide binding]; other site 290338008841 active site 290338008842 metal binding site [ion binding]; metal-binding site 290338008843 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 290338008844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338008845 non-specific DNA binding site [nucleotide binding]; other site 290338008846 salt bridge; other site 290338008847 sequence-specific DNA binding site [nucleotide binding]; other site 290338008848 Cupin domain; Region: Cupin_2; cl17218 290338008849 AzlC protein; Region: AzlC; cl00570 290338008850 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 290338008851 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 290338008852 hypothetical protein; Provisional; Region: PRK15301 290338008853 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 290338008854 PapC N-terminal domain; Region: PapC_N; pfam13954 290338008855 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338008856 PapC C-terminal domain; Region: PapC_C; pfam13953 290338008857 putative fimbrial chaperone protein; Provisional; Region: PRK09918 290338008858 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338008859 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290338008860 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338008861 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338008862 molybdopterin cofactor binding site; other site 290338008863 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 290338008864 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 290338008865 molybdopterin cofactor binding site; other site 290338008866 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 290338008867 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 290338008868 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 290338008869 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 290338008870 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 290338008871 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 290338008872 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 290338008873 oligomeric interface; other site 290338008874 putative active site [active] 290338008875 homodimer interface [polypeptide binding]; other site 290338008876 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 290338008877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338008878 Coenzyme A binding pocket [chemical binding]; other site 290338008879 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 290338008880 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 290338008881 putative active site [active] 290338008882 dimerization interface [polypeptide binding]; other site 290338008883 putative tRNAtyr binding site [nucleotide binding]; other site 290338008884 hypothetical protein; Reviewed; Region: PRK01637 290338008885 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 290338008886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338008887 motif II; other site 290338008888 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 290338008889 Autotransporter beta-domain; Region: Autotransporter; pfam03797 290338008890 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290338008891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290338008892 putative DNA binding site [nucleotide binding]; other site 290338008893 putative Zn2+ binding site [ion binding]; other site 290338008894 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338008895 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338008896 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 290338008897 substrate binding site [chemical binding]; other site 290338008898 ATP binding site [chemical binding]; other site 290338008899 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 290338008900 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290338008901 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 290338008902 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 290338008903 dimerization interface [polypeptide binding]; other site 290338008904 putative active cleft [active] 290338008905 alpha-glucosidase; Provisional; Region: PRK10426 290338008906 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 290338008907 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 290338008908 putative active site [active] 290338008909 putative catalytic site [active] 290338008910 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 290338008911 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290338008912 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 290338008913 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 290338008914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338008915 putative substrate translocation pore; other site 290338008916 outer membrane porin L; Provisional; Region: ompL; PRK09980 290338008917 GTP-binding protein; Provisional; Region: PRK10218 290338008918 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290338008919 G1 box; other site 290338008920 putative GEF interaction site [polypeptide binding]; other site 290338008921 GTP/Mg2+ binding site [chemical binding]; other site 290338008922 Switch I region; other site 290338008923 G2 box; other site 290338008924 G3 box; other site 290338008925 Switch II region; other site 290338008926 G4 box; other site 290338008927 G5 box; other site 290338008928 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 290338008929 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290338008930 glutamine synthetase; Provisional; Region: glnA; PRK09469 290338008931 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290338008932 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290338008933 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 290338008934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 290338008935 putative active site [active] 290338008936 heme pocket [chemical binding]; other site 290338008937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338008938 dimer interface [polypeptide binding]; other site 290338008939 phosphorylation site [posttranslational modification] 290338008940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338008941 ATP binding site [chemical binding]; other site 290338008942 Mg2+ binding site [ion binding]; other site 290338008943 G-X-G motif; other site 290338008944 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 290338008945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338008946 active site 290338008947 phosphorylation site [posttranslational modification] 290338008948 intermolecular recognition site; other site 290338008949 dimerization interface [polypeptide binding]; other site 290338008950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338008951 Walker A motif; other site 290338008952 ATP binding site [chemical binding]; other site 290338008953 Walker B motif; other site 290338008954 arginine finger; other site 290338008955 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338008956 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 290338008957 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338008958 FeS/SAM binding site; other site 290338008959 HemN C-terminal domain; Region: HemN_C; pfam06969 290338008960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 290338008961 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 290338008962 G1 box; other site 290338008963 GTP/Mg2+ binding site [chemical binding]; other site 290338008964 Switch I region; other site 290338008965 G2 box; other site 290338008966 G3 box; other site 290338008967 Switch II region; other site 290338008968 G4 box; other site 290338008969 G5 box; other site 290338008970 DNA polymerase I; Provisional; Region: PRK05755 290338008971 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290338008972 active site 290338008973 metal binding site 1 [ion binding]; metal-binding site 290338008974 putative 5' ssDNA interaction site; other site 290338008975 metal binding site 3; metal-binding site 290338008976 metal binding site 2 [ion binding]; metal-binding site 290338008977 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290338008978 putative DNA binding site [nucleotide binding]; other site 290338008979 putative metal binding site [ion binding]; other site 290338008980 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 290338008981 active site 290338008982 catalytic site [active] 290338008983 substrate binding site [chemical binding]; other site 290338008984 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290338008985 active site 290338008986 DNA binding site [nucleotide binding] 290338008987 catalytic site [active] 290338008988 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290338008989 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 290338008990 putative acyl-acceptor binding pocket; other site 290338008991 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 290338008992 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290338008993 catalytic residues [active] 290338008994 hinge region; other site 290338008995 alpha helical domain; other site 290338008996 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 290338008997 serine/threonine protein kinase; Provisional; Region: PRK11768 290338008998 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 290338008999 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 290338009000 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 290338009001 GTP binding site; other site 290338009002 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 290338009003 Walker A motif; other site 290338009004 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 290338009005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338009006 active site 290338009007 motif I; other site 290338009008 motif II; other site 290338009009 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290338009010 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290338009011 Walker A/P-loop; other site 290338009012 ATP binding site [chemical binding]; other site 290338009013 Q-loop/lid; other site 290338009014 ABC transporter signature motif; other site 290338009015 Walker B; other site 290338009016 D-loop; other site 290338009017 H-loop/switch region; other site 290338009018 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 290338009019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338009020 dimer interface [polypeptide binding]; other site 290338009021 conserved gate region; other site 290338009022 ABC-ATPase subunit interface; other site 290338009023 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 290338009024 lipoprotein, YaeC family; Region: TIGR00363 290338009025 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 290338009026 Uncharacterized conserved protein [Function unknown]; Region: COG1720 290338009027 homodimer interaction site [polypeptide binding]; other site 290338009028 cofactor binding site; other site 290338009029 prolyl-tRNA synthetase; Provisional; Region: PRK09194 290338009030 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 290338009031 dimer interface [polypeptide binding]; other site 290338009032 motif 1; other site 290338009033 active site 290338009034 motif 2; other site 290338009035 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 290338009036 putative deacylase active site [active] 290338009037 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290338009038 active site 290338009039 motif 3; other site 290338009040 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 290338009041 anticodon binding site; other site 290338009042 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 290338009043 NlpE N-terminal domain; Region: NlpE; pfam04170 290338009044 hypothetical protein; Provisional; Region: PRK09256 290338009045 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 290338009046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 290338009047 hypothetical protein; Provisional; Region: PRK04964 290338009048 Rho-binding antiterminator; Provisional; Region: PRK11625 290338009049 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 290338009050 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290338009051 Ligand Binding Site [chemical binding]; other site 290338009052 TilS substrate binding domain; Region: TilS; pfam09179 290338009053 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 290338009054 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 290338009055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290338009056 putative metal binding site [ion binding]; other site 290338009057 lysine decarboxylase LdcC; Provisional; Region: PRK15399 290338009058 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 290338009059 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 290338009060 homodimer interface [polypeptide binding]; other site 290338009061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338009062 catalytic residue [active] 290338009063 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 290338009064 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 290338009065 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 290338009066 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290338009067 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 290338009068 putative active site [active] 290338009069 putative PHP Thumb interface [polypeptide binding]; other site 290338009070 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290338009071 generic binding surface II; other site 290338009072 generic binding surface I; other site 290338009073 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290338009074 RNA/DNA hybrid binding site [nucleotide binding]; other site 290338009075 active site 290338009076 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 290338009077 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 290338009078 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 290338009079 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290338009080 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290338009081 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 290338009082 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 290338009083 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 290338009084 trimer interface [polypeptide binding]; other site 290338009085 active site 290338009086 UDP-GlcNAc binding site [chemical binding]; other site 290338009087 lipid binding site [chemical binding]; lipid-binding site 290338009088 periplasmic chaperone; Provisional; Region: PRK10780 290338009089 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 290338009090 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 290338009091 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290338009092 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290338009093 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290338009094 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290338009095 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290338009096 Surface antigen; Region: Bac_surface_Ag; pfam01103 290338009097 zinc metallopeptidase RseP; Provisional; Region: PRK10779 290338009098 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290338009099 active site 290338009100 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290338009101 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290338009102 protein binding site [polypeptide binding]; other site 290338009103 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290338009104 putative substrate binding region [chemical binding]; other site 290338009105 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 290338009106 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 290338009107 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 290338009108 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290338009109 catalytic residue [active] 290338009110 putative FPP diphosphate binding site; other site 290338009111 putative FPP binding hydrophobic cleft; other site 290338009112 dimer interface [polypeptide binding]; other site 290338009113 putative IPP diphosphate binding site; other site 290338009114 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290338009115 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290338009116 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290338009117 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290338009118 ribosome recycling factor; Reviewed; Region: frr; PRK00083 290338009119 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 290338009120 hinge region; other site 290338009121 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290338009122 putative nucleotide binding site [chemical binding]; other site 290338009123 uridine monophosphate binding site [chemical binding]; other site 290338009124 homohexameric interface [polypeptide binding]; other site 290338009125 elongation factor Ts; Provisional; Region: tsf; PRK09377 290338009126 UBA/TS-N domain; Region: UBA; pfam00627 290338009127 Elongation factor TS; Region: EF_TS; pfam00889 290338009128 Elongation factor TS; Region: EF_TS; pfam00889 290338009129 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290338009130 rRNA interaction site [nucleotide binding]; other site 290338009131 S8 interaction site; other site 290338009132 putative laminin-1 binding site; other site 290338009133 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290338009134 active site 290338009135 PII uridylyl-transferase; Provisional; Region: PRK05007 290338009136 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290338009137 metal binding triad; other site 290338009138 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290338009139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290338009140 Zn2+ binding site [ion binding]; other site 290338009141 Mg2+ binding site [ion binding]; other site 290338009142 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 290338009143 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 290338009144 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 290338009145 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 290338009146 trimer interface [polypeptide binding]; other site 290338009147 active site 290338009148 substrate binding site [chemical binding]; other site 290338009149 CoA binding site [chemical binding]; other site 290338009150 hypothetical protein; Provisional; Region: PRK13677 290338009151 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 290338009152 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 290338009153 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290338009154 serine endoprotease; Provisional; Region: PRK10942 290338009155 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290338009156 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290338009157 protein binding site [polypeptide binding]; other site 290338009158 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290338009159 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 290338009160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290338009161 Zn2+ binding site [ion binding]; other site 290338009162 Mg2+ binding site [ion binding]; other site 290338009163 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 290338009164 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 290338009165 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 290338009166 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 290338009167 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 290338009168 cobalamin binding residues [chemical binding]; other site 290338009169 putative BtuC binding residues; other site 290338009170 dimer interface [polypeptide binding]; other site 290338009171 hypothetical protein; Provisional; Region: PRK10578 290338009172 UPF0126 domain; Region: UPF0126; pfam03458 290338009173 UPF0126 domain; Region: UPF0126; pfam03458 290338009174 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 290338009175 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 290338009176 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 290338009177 Cl- selectivity filter; other site 290338009178 Cl- binding residues [ion binding]; other site 290338009179 pore gating glutamate residue; other site 290338009180 dimer interface [polypeptide binding]; other site 290338009181 H+/Cl- coupling transport residue; other site 290338009182 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338009183 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290338009184 inhibitor-cofactor binding pocket; inhibition site 290338009185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338009186 catalytic residue [active] 290338009187 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338009188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338009189 ABC-ATPase subunit interface; other site 290338009190 dimer interface [polypeptide binding]; other site 290338009191 putative PBP binding regions; other site 290338009192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338009193 ABC-ATPase subunit interface; other site 290338009194 dimer interface [polypeptide binding]; other site 290338009195 putative PBP binding regions; other site 290338009196 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290338009197 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290338009198 siderophore binding site; other site 290338009199 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 290338009200 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338009201 Walker A/P-loop; other site 290338009202 ATP binding site [chemical binding]; other site 290338009203 Q-loop/lid; other site 290338009204 ABC transporter signature motif; other site 290338009205 Walker B; other site 290338009206 D-loop; other site 290338009207 H-loop/switch region; other site 290338009208 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 290338009209 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338009210 N-terminal plug; other site 290338009211 ligand-binding site [chemical binding]; other site 290338009212 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 290338009213 Transglycosylase; Region: Transgly; pfam00912 290338009214 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290338009215 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 290338009216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338009217 ATP binding site [chemical binding]; other site 290338009218 putative Mg++ binding site [ion binding]; other site 290338009219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338009220 nucleotide binding region [chemical binding]; other site 290338009221 ATP-binding site [chemical binding]; other site 290338009222 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 290338009223 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 290338009224 2'-5' RNA ligase; Provisional; Region: PRK15124 290338009225 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290338009226 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290338009227 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 290338009228 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 290338009229 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 290338009230 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 290338009231 active site 290338009232 HIGH motif; other site 290338009233 nucleotide binding site [chemical binding]; other site 290338009234 KMSKS motif; other site 290338009235 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 290338009236 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290338009237 active site 290338009238 NTP binding site [chemical binding]; other site 290338009239 metal binding triad [ion binding]; metal-binding site 290338009240 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290338009241 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 290338009242 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290338009243 catalytic center binding site [active] 290338009244 ATP binding site [chemical binding]; other site 290338009245 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290338009246 oligomerization interface [polypeptide binding]; other site 290338009247 active site 290338009248 metal binding site [ion binding]; metal-binding site 290338009249 pantoate--beta-alanine ligase; Region: panC; TIGR00018 290338009250 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290338009251 active site 290338009252 ATP-binding site [chemical binding]; other site 290338009253 pantoate-binding site; other site 290338009254 HXXH motif; other site 290338009255 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290338009256 tetramerization interface [polypeptide binding]; other site 290338009257 active site 290338009258 major fimbrial protein StkA; Provisional; Region: PRK15307 290338009259 putative chaperone protein EcpD; Provisional; Region: PRK09926 290338009260 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338009261 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338009262 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 290338009263 PapC N-terminal domain; Region: PapC_N; pfam13954 290338009264 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338009265 PapC C-terminal domain; Region: PapC_C; pfam13953 290338009266 Fimbrial protein; Region: Fimbrial; cl01416 290338009267 putative fimbrial protein StaE; Provisional; Region: PRK15263 290338009268 putative fimbrial protein StaF; Provisional; Region: PRK15262 290338009269 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338009270 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 290338009271 active pocket/dimerization site; other site 290338009272 active site 290338009273 phosphorylation site [posttranslational modification] 290338009274 inner membrane transport permease; Provisional; Region: PRK15066 290338009275 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290338009276 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290338009277 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290338009278 Walker A/P-loop; other site 290338009279 ATP binding site [chemical binding]; other site 290338009280 Q-loop/lid; other site 290338009281 ABC transporter signature motif; other site 290338009282 Walker B; other site 290338009283 D-loop; other site 290338009284 H-loop/switch region; other site 290338009285 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 290338009286 active site clefts [active] 290338009287 zinc binding site [ion binding]; other site 290338009288 dimer interface [polypeptide binding]; other site 290338009289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338009290 active site 290338009291 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 290338009292 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 290338009293 Trp docking motif [polypeptide binding]; other site 290338009294 putative active site [active] 290338009295 multicopper oxidase; Provisional; Region: PRK10965 290338009296 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290338009297 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290338009298 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 290338009299 spermidine synthase; Provisional; Region: PRK00811 290338009300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338009301 S-adenosylmethionine binding site [chemical binding]; other site 290338009302 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 290338009303 hypothetical protein; Provisional; Region: PRK05248 290338009304 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 290338009305 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 290338009306 substrate binding site [chemical binding]; other site 290338009307 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 290338009308 substrate binding site [chemical binding]; other site 290338009309 ligand binding site [chemical binding]; other site 290338009310 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 290338009311 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 290338009312 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 290338009313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290338009314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338009315 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290338009316 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 290338009317 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290338009318 E3 interaction surface; other site 290338009319 lipoyl attachment site [posttranslational modification]; other site 290338009320 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290338009321 E3 interaction surface; other site 290338009322 lipoyl attachment site [posttranslational modification]; other site 290338009323 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290338009324 E3 interaction surface; other site 290338009325 lipoyl attachment site [posttranslational modification]; other site 290338009326 e3 binding domain; Region: E3_binding; pfam02817 290338009327 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290338009328 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290338009329 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290338009330 dimer interface [polypeptide binding]; other site 290338009331 TPP-binding site [chemical binding]; other site 290338009332 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290338009333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338009334 DNA-binding site [nucleotide binding]; DNA binding site 290338009335 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290338009336 aromatic amino acid transporter; Provisional; Region: PRK10238 290338009337 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290338009338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338009339 putative substrate translocation pore; other site 290338009340 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 290338009341 active site 290338009342 regulatory protein AmpE; Provisional; Region: PRK10987 290338009343 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 290338009344 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 290338009345 amidase catalytic site [active] 290338009346 substrate binding site [chemical binding]; other site 290338009347 Zn binding residues [ion binding]; other site 290338009348 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 290338009349 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290338009350 dimerization interface [polypeptide binding]; other site 290338009351 active site 290338009352 putative major pilin subunit; Provisional; Region: PRK10574 290338009353 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 290338009354 Pilin (bacterial filament); Region: Pilin; pfam00114 290338009355 hypothetical protein; Provisional; Region: PRK10436 290338009356 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 290338009357 Walker A motif; other site 290338009358 ATP binding site [chemical binding]; other site 290338009359 Walker B motif; other site 290338009360 type IV pilin biogenesis protein; Provisional; Region: PRK10573 290338009361 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290338009362 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290338009363 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 290338009364 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290338009365 active site 290338009366 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 290338009367 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290338009368 CoA-binding site [chemical binding]; other site 290338009369 ATP-binding [chemical binding]; other site 290338009370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 290338009371 DNA gyrase inhibitor; Reviewed; Region: PRK00418 290338009372 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290338009373 active site 290338009374 8-oxo-dGMP binding site [chemical binding]; other site 290338009375 nudix motif; other site 290338009376 metal binding site [ion binding]; metal-binding site 290338009377 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 290338009378 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 290338009379 SEC-C motif; Region: SEC-C; pfam02810 290338009380 SecA regulator SecM; Provisional; Region: PRK02943 290338009381 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 290338009382 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 290338009383 cell division protein FtsZ; Validated; Region: PRK09330 290338009384 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290338009385 nucleotide binding site [chemical binding]; other site 290338009386 SulA interaction site; other site 290338009387 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 290338009388 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338009389 Cell division protein FtsA; Region: FtsA; pfam14450 290338009390 cell division protein FtsQ; Provisional; Region: PRK10775 290338009391 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290338009392 Cell division protein FtsQ; Region: FtsQ; pfam03799 290338009393 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 290338009394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290338009395 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 290338009396 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290338009397 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290338009398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290338009399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290338009400 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 290338009401 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290338009402 active site 290338009403 homodimer interface [polypeptide binding]; other site 290338009404 cell division protein FtsW; Provisional; Region: PRK10774 290338009405 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 290338009406 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290338009407 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290338009408 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290338009409 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290338009410 Mg++ binding site [ion binding]; other site 290338009411 putative catalytic motif [active] 290338009412 putative substrate binding site [chemical binding]; other site 290338009413 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 290338009414 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290338009415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290338009416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290338009417 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290338009418 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290338009419 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290338009420 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290338009421 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 290338009422 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290338009423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290338009424 cell division protein FtsL; Provisional; Region: PRK10772 290338009425 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 290338009426 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 290338009427 mraZ protein; Region: TIGR00242 290338009428 MraZ protein; Region: MraZ; pfam02381 290338009429 MraZ protein; Region: MraZ; pfam02381 290338009430 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 290338009431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338009432 DNA binding site [nucleotide binding] 290338009433 domain linker motif; other site 290338009434 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 290338009435 dimerization interface [polypeptide binding]; other site 290338009436 ligand binding site [chemical binding]; other site 290338009437 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290338009438 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290338009439 putative valine binding site [chemical binding]; other site 290338009440 dimer interface [polypeptide binding]; other site 290338009441 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290338009442 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 290338009443 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290338009444 PYR/PP interface [polypeptide binding]; other site 290338009445 dimer interface [polypeptide binding]; other site 290338009446 TPP binding site [chemical binding]; other site 290338009447 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290338009448 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290338009449 TPP-binding site [chemical binding]; other site 290338009450 dimer interface [polypeptide binding]; other site 290338009451 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 290338009452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338009453 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 290338009454 putative substrate binding pocket [chemical binding]; other site 290338009455 putative dimerization interface [polypeptide binding]; other site 290338009456 leucine operon leader 290338009457 2-isopropylmalate synthase; Validated; Region: PRK00915 290338009458 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 290338009459 active site 290338009460 catalytic residues [active] 290338009461 metal binding site [ion binding]; metal-binding site 290338009462 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 290338009463 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 290338009464 tartrate dehydrogenase; Region: TTC; TIGR02089 290338009465 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290338009466 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290338009467 substrate binding site [chemical binding]; other site 290338009468 ligand binding site [chemical binding]; other site 290338009469 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 290338009470 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290338009471 substrate binding site [chemical binding]; other site 290338009472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338009473 sugar efflux transporter; Region: 2A0120; TIGR00899 290338009474 putative substrate translocation pore; other site 290338009475 transcriptional regulator SgrR; Provisional; Region: PRK13626 290338009476 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 290338009477 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 290338009478 TPP riboswitch (THI element) 290338009479 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 290338009480 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 290338009481 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 290338009482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338009483 dimer interface [polypeptide binding]; other site 290338009484 conserved gate region; other site 290338009485 putative PBP binding loops; other site 290338009486 ABC-ATPase subunit interface; other site 290338009487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338009488 dimer interface [polypeptide binding]; other site 290338009489 conserved gate region; other site 290338009490 putative PBP binding loops; other site 290338009491 ABC-ATPase subunit interface; other site 290338009492 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 290338009493 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 290338009494 Walker A/P-loop; other site 290338009495 ATP binding site [chemical binding]; other site 290338009496 Q-loop/lid; other site 290338009497 ABC transporter signature motif; other site 290338009498 Walker B; other site 290338009499 D-loop; other site 290338009500 H-loop/switch region; other site 290338009501 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290338009502 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290338009503 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 290338009504 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338009505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338009506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338009507 ribulokinase; Provisional; Region: PRK04123 290338009508 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 290338009509 N- and C-terminal domain interface [polypeptide binding]; other site 290338009510 active site 290338009511 MgATP binding site [chemical binding]; other site 290338009512 catalytic site [active] 290338009513 metal binding site [ion binding]; metal-binding site 290338009514 carbohydrate binding site [chemical binding]; other site 290338009515 homodimer interface [polypeptide binding]; other site 290338009516 L-arabinose isomerase; Provisional; Region: PRK02929 290338009517 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 290338009518 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 290338009519 trimer interface [polypeptide binding]; other site 290338009520 putative substrate binding site [chemical binding]; other site 290338009521 putative metal binding site [ion binding]; other site 290338009522 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 290338009523 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290338009524 intersubunit interface [polypeptide binding]; other site 290338009525 active site 290338009526 Zn2+ binding site [ion binding]; other site 290338009527 DNA polymerase II; Reviewed; Region: PRK05762 290338009528 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 290338009529 active site 290338009530 catalytic site [active] 290338009531 substrate binding site [chemical binding]; other site 290338009532 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 290338009533 active site 290338009534 metal-binding site 290338009535 ATP-dependent helicase HepA; Validated; Region: PRK04914 290338009536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338009537 ATP binding site [chemical binding]; other site 290338009538 putative Mg++ binding site [ion binding]; other site 290338009539 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338009540 nucleotide binding region [chemical binding]; other site 290338009541 ATP-binding site [chemical binding]; other site 290338009542 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290338009543 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290338009544 active site 290338009545 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 290338009546 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 290338009547 putative metal binding site [ion binding]; other site 290338009548 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290338009549 HSP70 interaction site [polypeptide binding]; other site 290338009550 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 290338009551 OstA-like protein; Region: OstA; pfam03968 290338009552 Organic solvent tolerance protein; Region: OstA_C; pfam04453 290338009553 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 290338009554 SurA N-terminal domain; Region: SurA_N; pfam09312 290338009555 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290338009556 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290338009557 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 290338009558 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 290338009559 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 290338009560 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 290338009561 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 290338009562 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 290338009563 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 290338009564 active site 290338009565 metal binding site [ion binding]; metal-binding site 290338009566 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290338009567 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 290338009568 folate binding site [chemical binding]; other site 290338009569 NADP+ binding site [chemical binding]; other site 290338009570 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 290338009571 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 290338009572 TrkA-N domain; Region: TrkA_N; pfam02254 290338009573 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 290338009574 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 290338009575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338009576 benzoate transport; Region: 2A0115; TIGR00895 290338009577 putative substrate translocation pore; other site 290338009578 ferredoxin-like protein FixX; Provisional; Region: PRK15449 290338009579 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 290338009580 putative oxidoreductase FixC; Provisional; Region: PRK10157 290338009581 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 290338009582 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 290338009583 Ligand binding site [chemical binding]; other site 290338009584 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290338009585 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 290338009586 Ligand binding site [chemical binding]; other site 290338009587 Electron transfer flavoprotein domain; Region: ETF; pfam01012 290338009588 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 290338009589 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 290338009590 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 290338009591 active site 290338009592 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 290338009593 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290338009594 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 290338009595 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338009596 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 290338009597 acyl-activating enzyme (AAE) consensus motif; other site 290338009598 putative AMP binding site [chemical binding]; other site 290338009599 putative active site [active] 290338009600 putative CoA binding site [chemical binding]; other site 290338009601 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 290338009602 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290338009603 substrate binding site [chemical binding]; other site 290338009604 oxyanion hole (OAH) forming residues; other site 290338009605 trimer interface [polypeptide binding]; other site 290338009606 carnitine operon protein CaiE; Provisional; Region: PRK13627 290338009607 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 290338009608 putative trimer interface [polypeptide binding]; other site 290338009609 putative metal binding site [ion binding]; other site 290338009610 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 290338009611 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 290338009612 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290338009613 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290338009614 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290338009615 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290338009616 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290338009617 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290338009618 IMP binding site; other site 290338009619 dimer interface [polypeptide binding]; other site 290338009620 interdomain contacts; other site 290338009621 partial ornithine binding site; other site 290338009622 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290338009623 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 290338009624 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290338009625 catalytic site [active] 290338009626 subunit interface [polypeptide binding]; other site 290338009627 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 290338009628 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 290338009629 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290338009630 alanine-tRNA ligase; Region: PLN02961 290338009631 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 290338009632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338009633 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338009634 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290338009635 putative effector binding pocket; other site 290338009636 dimerization interface [polypeptide binding]; other site 290338009637 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 290338009638 active site 290338009639 tetramer interface [polypeptide binding]; other site 290338009640 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290338009641 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290338009642 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 290338009643 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290338009644 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338009645 putative active site [active] 290338009646 heme pocket [chemical binding]; other site 290338009647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338009648 ATP binding site [chemical binding]; other site 290338009649 Mg2+ binding site [ion binding]; other site 290338009650 G-X-G motif; other site 290338009651 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290338009652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338009653 active site 290338009654 phosphorylation site [posttranslational modification] 290338009655 intermolecular recognition site; other site 290338009656 dimerization interface [polypeptide binding]; other site 290338009657 Transcriptional regulator; Region: CitT; pfam12431 290338009658 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 290338009659 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 290338009660 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 290338009661 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290338009662 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 290338009663 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 290338009664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290338009665 active site 290338009666 HIGH motif; other site 290338009667 nucleotide binding site [chemical binding]; other site 290338009668 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290338009669 active site 290338009670 KMSKS motif; other site 290338009671 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 290338009672 tRNA binding surface [nucleotide binding]; other site 290338009673 anticodon binding site; other site 290338009674 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290338009675 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290338009676 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290338009677 active site 290338009678 Riboflavin kinase; Region: Flavokinase; smart00904 290338009679 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 290338009680 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 290338009681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338009682 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 290338009683 putative dimerization interface [polypeptide binding]; other site 290338009684 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 290338009685 chaperone protein DnaJ; Provisional; Region: PRK10767 290338009686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290338009687 HSP70 interaction site [polypeptide binding]; other site 290338009688 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 290338009689 substrate binding site [polypeptide binding]; other site 290338009690 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290338009691 Zn binding sites [ion binding]; other site 290338009692 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290338009693 dimer interface [polypeptide binding]; other site 290338009694 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 290338009695 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290338009696 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290338009697 nucleotide binding site [chemical binding]; other site 290338009698 hypothetical protein; Provisional; Region: PRK10659 290338009699 metabolite-proton symporter; Region: 2A0106; TIGR00883 290338009700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338009701 putative substrate translocation pore; other site 290338009702 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290338009703 MPT binding site; other site 290338009704 trimer interface [polypeptide binding]; other site 290338009705 transaldolase-like protein; Provisional; Region: PTZ00411 290338009706 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 290338009707 active site 290338009708 dimer interface [polypeptide binding]; other site 290338009709 catalytic residue [active] 290338009710 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 290338009711 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 290338009712 hypothetical protein; Validated; Region: PRK02101 290338009713 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 290338009714 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 290338009715 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 290338009716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338009717 catalytic residue [active] 290338009718 homoserine kinase; Provisional; Region: PRK01212 290338009719 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290338009720 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 290338009721 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 290338009722 putative catalytic residues [active] 290338009723 putative nucleotide binding site [chemical binding]; other site 290338009724 putative aspartate binding site [chemical binding]; other site 290338009725 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 290338009726 dimer interface [polypeptide binding]; other site 290338009727 putative threonine allosteric regulatory site; other site 290338009728 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 290338009729 putative threonine allosteric regulatory site; other site 290338009730 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290338009731 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290338009732 threonine operon leader 290338009733 putative RNA methyltransferase; Provisional; Region: PRK10433 290338009734 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 290338009735 two-component response regulator; Provisional; Region: PRK11173 290338009736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338009737 active site 290338009738 phosphorylation site [posttranslational modification] 290338009739 intermolecular recognition site; other site 290338009740 dimerization interface [polypeptide binding]; other site 290338009741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338009742 DNA binding site [nucleotide binding] 290338009743 hypothetical protein; Provisional; Region: PRK10756 290338009744 CreA protein; Region: CreA; pfam05981 290338009745 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 290338009746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338009747 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 290338009748 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290338009749 catalytic core [active] 290338009750 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 290338009751 Trp operon repressor; Provisional; Region: PRK01381 290338009752 lytic murein transglycosylase; Provisional; Region: PRK11619 290338009753 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338009754 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338009755 catalytic residue [active] 290338009756 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 290338009757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338009758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338009759 ABC transporter; Region: ABC_tran_2; pfam12848 290338009760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338009761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338009762 non-specific DNA binding site [nucleotide binding]; other site 290338009763 salt bridge; other site 290338009764 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 290338009765 sequence-specific DNA binding site [nucleotide binding]; other site 290338009766 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 290338009767 active site 290338009768 (T/H)XGH motif; other site 290338009769 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 290338009770 DNA repair protein RadA; Region: sms; TIGR00416 290338009771 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 290338009772 Walker A motif/ATP binding site; other site 290338009773 ATP binding site [chemical binding]; other site 290338009774 Walker B motif; other site 290338009775 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290338009776 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 290338009777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338009778 motif II; other site 290338009779 hypothetical protein; Provisional; Region: PRK11246 290338009780 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 290338009781 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290338009782 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 290338009783 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 290338009784 putative fimbrial chaperone protein; Provisional; Region: PRK09918 290338009785 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338009786 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338009787 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 290338009788 PapC N-terminal domain; Region: PapC_N; pfam13954 290338009789 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338009790 PapC C-terminal domain; Region: PapC_C; pfam13953 290338009791 hypothetical protein; Provisional; Region: PRK15301 290338009792 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 290338009793 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 290338009794 phosphopentomutase; Provisional; Region: PRK05362 290338009795 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 290338009796 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 290338009797 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290338009798 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290338009799 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 290338009800 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 290338009801 intersubunit interface [polypeptide binding]; other site 290338009802 active site 290338009803 catalytic residue [active] 290338009804 hypothetical protein; Provisional; Region: PRK10977 290338009805 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 290338009806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338009807 FeS/SAM binding site; other site 290338009808 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290338009809 active site 290338009810 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 290338009811 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 290338009812 active site 290338009813 nucleophile elbow; other site 290338009814 periplasmic protein; Provisional; Region: PRK10568 290338009815 BON domain; Region: BON; pfam04972 290338009816 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 290338009817 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 290338009818 G1 box; other site 290338009819 putative GEF interaction site [polypeptide binding]; other site 290338009820 GTP/Mg2+ binding site [chemical binding]; other site 290338009821 Switch I region; other site 290338009822 G2 box; other site 290338009823 G3 box; other site 290338009824 Switch II region; other site 290338009825 G4 box; other site 290338009826 G5 box; other site 290338009827 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 290338009828 dUMP phosphatase; Provisional; Region: PRK09449 290338009829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338009830 motif II; other site 290338009831 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 290338009832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338009833 Coenzyme A binding pocket [chemical binding]; other site 290338009834 DNA polymerase III subunit psi; Validated; Region: PRK06856 290338009835 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 290338009836 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 290338009837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338009838 S-adenosylmethionine binding site [chemical binding]; other site 290338009839 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 290338009840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290338009841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338009842 metal binding site [ion binding]; metal-binding site 290338009843 active site 290338009844 I-site; other site 290338009845 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 290338009846 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290338009847 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 290338009848 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 290338009849 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 290338009850 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 290338009851 putative deacylase active site [active] 290338009852 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 290338009853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338009854 DNA binding residues [nucleotide binding] 290338009855 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338009856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338009857 DNA binding residues [nucleotide binding] 290338009858 dimerization interface [polypeptide binding]; other site 290338009859 Uncharacterized conserved protein [Function unknown]; Region: COG2966 290338009860 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 290338009861 hypothetical protein; Provisional; Region: PRK09917 290338009862 primosomal protein DnaI; Provisional; Region: PRK02854 290338009863 DNA replication protein DnaC; Validated; Region: PRK07952 290338009864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338009865 Walker A motif; other site 290338009866 ATP binding site [chemical binding]; other site 290338009867 Walker B motif; other site 290338009868 hypothetical protein; Provisional; Region: PRK11667 290338009869 phosphoglycerol transferase I; Provisional; Region: PRK03776 290338009870 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 290338009871 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290338009872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338009873 Coenzyme A binding pocket [chemical binding]; other site 290338009874 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290338009875 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290338009876 dimer interface [polypeptide binding]; other site 290338009877 ligand binding site [chemical binding]; other site 290338009878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338009879 dimerization interface [polypeptide binding]; other site 290338009880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338009881 dimer interface [polypeptide binding]; other site 290338009882 putative CheW interface [polypeptide binding]; other site 290338009883 carbon starvation protein A; Provisional; Region: PRK15015 290338009884 Carbon starvation protein CstA; Region: CstA; pfam02554 290338009885 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290338009886 Uncharacterized small protein [Function unknown]; Region: COG2879 290338009887 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 290338009888 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 290338009889 P-loop, Walker A motif; other site 290338009890 Base recognition motif; other site 290338009891 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 290338009892 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 290338009893 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 290338009894 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338009895 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338009896 transcriptional regulator SlyA; Provisional; Region: PRK03573 290338009897 MarR family; Region: MarR; pfam01047 290338009898 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 290338009899 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290338009900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338009901 DNA-binding site [nucleotide binding]; DNA binding site 290338009902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338009903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338009904 homodimer interface [polypeptide binding]; other site 290338009905 catalytic residue [active] 290338009906 putative transposase; Provisional; Region: PRK09857 290338009907 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 290338009908 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 290338009909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338009910 putative substrate translocation pore; other site 290338009911 cystathionine beta-lyase; Provisional; Region: PRK08114 290338009912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290338009913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338009914 catalytic residue [active] 290338009915 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 290338009916 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338009917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338009918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338009919 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290338009920 putative effector binding pocket; other site 290338009921 dimerization interface [polypeptide binding]; other site 290338009922 Predicted membrane protein [Function unknown]; Region: COG2733 290338009923 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 290338009924 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 290338009925 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 290338009926 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 290338009927 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 290338009928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338009929 putative substrate translocation pore; other site 290338009930 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290338009931 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290338009932 active site 290338009933 HIGH motif; other site 290338009934 dimer interface [polypeptide binding]; other site 290338009935 KMSKS motif; other site 290338009936 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 290338009937 aromatic amino acid transport protein; Region: araaP; TIGR00837 290338009938 tyrosine phenol-lyase; Provisional; Region: PRK13237 290338009939 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 290338009940 substrate binding site [chemical binding]; other site 290338009941 tetramer interface [polypeptide binding]; other site 290338009942 catalytic residue [active] 290338009943 Fic family protein [Function unknown]; Region: COG3177 290338009944 Fic/DOC family; Region: Fic; pfam02661 290338009945 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 290338009946 DNA binding site [nucleotide binding] 290338009947 EcoRII C terminal; Region: EcoRII-C; pfam09019 290338009948 DNA cytosine methylase; Provisional; Region: PRK10458 290338009949 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 290338009950 cofactor binding site; other site 290338009951 DNA binding site [nucleotide binding] 290338009952 substrate interaction site [chemical binding]; other site 290338009953 Part of AAA domain; Region: AAA_19; pfam13245 290338009954 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290338009955 AAA domain; Region: AAA_12; pfam13087 290338009956 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 290338009957 putative active site [active] 290338009958 catalytic site [active] 290338009959 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 290338009960 HNH endonuclease; Region: HNH_2; pfam13391 290338009961 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 290338009962 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 290338009963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290338009964 Walker A motif; other site 290338009965 ATP binding site [chemical binding]; other site 290338009966 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 290338009967 TraU protein; Region: TraU; cl06067 290338009968 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 290338009969 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 290338009970 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 290338009971 Protein of unknown function DUF262; Region: DUF262; pfam03235 290338009972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338009973 AAA domain; Region: AAA_21; pfam13304 290338009974 Walker A/P-loop; other site 290338009975 ATP binding site [chemical binding]; other site 290338009976 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 290338009977 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 290338009978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338009979 Walker A/P-loop; other site 290338009980 ATP binding site [chemical binding]; other site 290338009981 hypothetical protein; Provisional; Region: PRK06850 290338009982 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290338009983 Active Sites [active] 290338009984 DNA-sulfur modification-associated; Region: DndB; pfam14072 290338009985 DGQHR domain; Region: DGQHR; TIGR03187 290338009986 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 290338009987 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 290338009988 Putative helicase; Region: TraI_2; pfam07514 290338009989 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290338009990 Zn2+ binding site [ion binding]; other site 290338009991 Mg2+ binding site [ion binding]; other site 290338009992 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 290338009993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290338009994 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290338009995 DNA binding site [nucleotide binding] 290338009996 active site 290338009997 Int/Topo IB signature motif; other site 290338009998 catalytic residues [active] 290338009999 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290338010000 Ligand Binding Site [chemical binding]; other site 290338010001 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 290338010002 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 290338010003 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 290338010004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338010005 FeS/SAM binding site; other site 290338010006 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 290338010007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338010008 FeS/SAM binding site; other site 290338010009 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 290338010010 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290338010011 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 290338010012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 290338010013 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290338010014 active site 290338010015 catalytic residues [active] 290338010016 DNA binding site [nucleotide binding] 290338010017 Int/Topo IB signature motif; other site 290338010018 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290338010019 active site 290338010020 catalytic residues [active] 290338010021 DNA binding site [nucleotide binding] 290338010022 Int/Topo IB signature motif; other site 290338010023 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 290338010024 integrase; Provisional; Region: PRK09692 290338010025 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290338010026 active site 290338010027 Int/Topo IB signature motif; other site 290338010028 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290338010029 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290338010030 putative NAD(P) binding site [chemical binding]; other site 290338010031 putative substrate binding site [chemical binding]; other site 290338010032 catalytic Zn binding site [ion binding]; other site 290338010033 structural Zn binding site [ion binding]; other site 290338010034 dimer interface [polypeptide binding]; other site 290338010035 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 290338010036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290338010037 Walker A motif; other site 290338010038 ATP binding site [chemical binding]; other site 290338010039 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 290338010040 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290338010041 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 290338010042 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290338010043 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290338010044 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290338010045 interface (dimer of trimers) [polypeptide binding]; other site 290338010046 Substrate-binding/catalytic site; other site 290338010047 Zn-binding sites [ion binding]; other site 290338010048 DNA polymerase III subunit chi; Validated; Region: PRK05728 290338010049 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 290338010050 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290338010051 HIGH motif; other site 290338010052 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290338010053 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290338010054 active site 290338010055 KMSKS motif; other site 290338010056 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290338010057 tRNA binding surface [nucleotide binding]; other site 290338010058 anticodon binding site; other site 290338010059 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 290338010060 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 290338010061 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 290338010062 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 290338010063 Protein of unknown function (DUF3289); Region: DUF3289; pfam11692 290338010064 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290338010065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338010066 Coenzyme A binding pocket [chemical binding]; other site 290338010067 RNase E inhibitor protein; Provisional; Region: PRK11191 290338010068 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 290338010069 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 290338010070 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290338010071 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290338010072 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 290338010073 arginine deiminase; Provisional; Region: PRK01388 290338010074 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 290338010075 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 290338010076 putative substrate binding site [chemical binding]; other site 290338010077 nucleotide binding site [chemical binding]; other site 290338010078 nucleotide binding site [chemical binding]; other site 290338010079 homodimer interface [polypeptide binding]; other site 290338010080 ornithine carbamoyltransferase; Validated; Region: PRK02102 290338010081 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290338010082 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290338010083 Predicted membrane protein [Function unknown]; Region: COG1288 290338010084 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290338010085 Arginine repressor [Transcription]; Region: ArgR; COG1438 290338010086 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290338010087 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290338010088 pyrBI operon leader peptide; Provisional; Region: PRK10224 290338010089 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 290338010090 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290338010091 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290338010092 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 290338010093 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 290338010094 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 290338010095 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290338010096 homotrimer interaction site [polypeptide binding]; other site 290338010097 putative active site [active] 290338010098 DctM-like transporters; Region: DctM; pfam06808 290338010099 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 290338010100 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 290338010101 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 290338010102 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 290338010103 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290338010104 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290338010105 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 290338010106 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290338010107 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290338010108 trehalose repressor; Provisional; Region: treR; PRK09492 290338010109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338010110 DNA binding site [nucleotide binding] 290338010111 domain linker motif; other site 290338010112 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 290338010113 dimerization interface [polypeptide binding]; other site 290338010114 ligand binding site [chemical binding]; other site 290338010115 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 290338010116 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338010117 active site turn [active] 290338010118 phosphorylation site [posttranslational modification] 290338010119 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290338010120 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 290338010121 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 290338010122 Ca binding site [ion binding]; other site 290338010123 active site 290338010124 catalytic site [active] 290338010125 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290338010126 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 290338010127 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290338010128 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338010129 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338010130 putative active site [active] 290338010131 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290338010132 active site 290338010133 P-loop; other site 290338010134 phosphorylation site [posttranslational modification] 290338010135 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290338010136 alpha-mannosidase; Provisional; Region: PRK09819 290338010137 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 290338010138 active site 290338010139 metal binding site [ion binding]; metal-binding site 290338010140 catalytic site [active] 290338010141 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 290338010142 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 290338010143 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 290338010144 active site 290338010145 homodimer interface [polypeptide binding]; other site 290338010146 catalytic site [active] 290338010147 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338010148 active site 290338010149 phosphorylation site [posttranslational modification] 290338010150 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 290338010151 ATP cone domain; Region: ATP-cone; pfam03477 290338010152 Class III ribonucleotide reductase; Region: RNR_III; cd01675 290338010153 effector binding site; other site 290338010154 active site 290338010155 Zn binding site [ion binding]; other site 290338010156 glycine loop; other site 290338010157 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 290338010158 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338010159 FeS/SAM binding site; other site 290338010160 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 290338010161 HTH domain; Region: HTH_11; pfam08279 290338010162 Mga helix-turn-helix domain; Region: Mga; pfam05043 290338010163 PRD domain; Region: PRD; pfam00874 290338010164 PRD domain; Region: PRD; pfam00874 290338010165 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 290338010166 active site 290338010167 P-loop; other site 290338010168 phosphorylation site [posttranslational modification] 290338010169 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338010170 active site 290338010171 phosphorylation site [posttranslational modification] 290338010172 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 290338010173 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 290338010174 dihydroorotase; Provisional; Region: PRK09237 290338010175 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 290338010176 active site 290338010177 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 290338010178 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 290338010179 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 290338010180 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 290338010181 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 290338010182 cytochrome b562; Provisional; Region: PRK15058 290338010183 peptidase PmbA; Provisional; Region: PRK11040 290338010184 hypothetical protein; Provisional; Region: PRK05255 290338010185 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 290338010186 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290338010187 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290338010188 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290338010189 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 290338010190 AMP binding site [chemical binding]; other site 290338010191 metal binding site [ion binding]; metal-binding site 290338010192 active site 290338010193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338010194 dimerization interface [polypeptide binding]; other site 290338010195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290338010196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338010197 dimer interface [polypeptide binding]; other site 290338010198 putative CheW interface [polypeptide binding]; other site 290338010199 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338010200 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338010201 TM-ABC transporter signature motif; other site 290338010202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338010203 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338010204 TM-ABC transporter signature motif; other site 290338010205 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290338010206 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338010207 Walker A/P-loop; other site 290338010208 ATP binding site [chemical binding]; other site 290338010209 Q-loop/lid; other site 290338010210 ABC transporter signature motif; other site 290338010211 Walker B; other site 290338010212 D-loop; other site 290338010213 H-loop/switch region; other site 290338010214 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338010215 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 290338010216 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290338010217 putative ligand binding site [chemical binding]; other site 290338010218 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 290338010219 dimer interface [polypeptide binding]; other site 290338010220 substrate binding site [chemical binding]; other site 290338010221 metal binding sites [ion binding]; metal-binding site 290338010222 Protein of unknown function (DUF796); Region: DUF796; cl01226 290338010223 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 290338010224 putative active site pocket [active] 290338010225 dimerization interface [polypeptide binding]; other site 290338010226 putative catalytic residue [active] 290338010227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 290338010228 Family of unknown function (DUF490); Region: DUF490; pfam04357 290338010229 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 290338010230 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290338010231 Surface antigen; Region: Bac_surface_Ag; pfam01103 290338010232 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 290338010233 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290338010234 Domain of unknown function DUF21; Region: DUF21; pfam01595 290338010235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290338010236 Transporter associated domain; Region: CorC_HlyC; smart01091 290338010237 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 290338010238 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 290338010239 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 290338010240 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290338010241 active site 290338010242 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 290338010243 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 290338010244 active site 290338010245 metal binding site [ion binding]; metal-binding site 290338010246 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290338010247 Predicted transcriptional regulators [Transcription]; Region: COG1733 290338010248 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290338010249 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290338010250 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 290338010251 NADP binding site [chemical binding]; other site 290338010252 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290338010253 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290338010254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338010255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338010256 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290338010257 EamA-like transporter family; Region: EamA; pfam00892 290338010258 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290338010259 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 290338010260 dimer interface [polypeptide binding]; other site 290338010261 ligand binding site [chemical binding]; other site 290338010262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338010263 dimerization interface [polypeptide binding]; other site 290338010264 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338010265 dimer interface [polypeptide binding]; other site 290338010266 putative CheW interface [polypeptide binding]; other site 290338010267 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 290338010268 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 290338010269 Hemerythrin-like domain; Region: Hr-like; cd12108 290338010270 Fe binding site [ion binding]; other site 290338010271 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290338010272 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 290338010273 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 290338010274 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290338010275 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 290338010276 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 290338010277 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290338010278 EamA-like transporter family; Region: EamA; pfam00892 290338010279 EamA-like transporter family; Region: EamA; pfam00892 290338010280 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290338010281 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290338010282 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290338010283 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 290338010284 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290338010285 dimer interface [polypeptide binding]; other site 290338010286 ssDNA binding site [nucleotide binding]; other site 290338010287 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290338010288 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 290338010289 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338010290 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 290338010291 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290338010292 intersubunit interface [polypeptide binding]; other site 290338010293 active site 290338010294 Zn2+ binding site [ion binding]; other site 290338010295 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 290338010296 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 290338010297 AP (apurinic/apyrimidinic) site pocket; other site 290338010298 DNA interaction; other site 290338010299 Metal-binding active site; metal-binding site 290338010300 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 290338010301 active site 290338010302 dimer interface [polypeptide binding]; other site 290338010303 magnesium binding site [ion binding]; other site 290338010304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338010305 active site 290338010306 phosphorylation site [posttranslational modification] 290338010307 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 290338010308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 290338010309 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 290338010310 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 290338010311 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290338010312 transcriptional repressor UlaR; Provisional; Region: PRK13509 290338010313 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290338010314 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338010315 esterase; Provisional; Region: PRK10566 290338010316 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290338010317 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 290338010318 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338010319 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 290338010320 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 290338010321 FAD binding site [chemical binding]; other site 290338010322 substrate binding site [chemical binding]; other site 290338010323 catalytic residues [active] 290338010324 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 290338010325 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 290338010326 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290338010327 exoribonuclease R; Provisional; Region: PRK11642 290338010328 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 290338010329 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290338010330 RNB domain; Region: RNB; pfam00773 290338010331 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 290338010332 RNA binding site [nucleotide binding]; other site 290338010333 Predicted transcriptional regulator [Transcription]; Region: COG1959 290338010334 transcriptional repressor NsrR; Provisional; Region: PRK11014 290338010335 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290338010336 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290338010337 GDP-binding site [chemical binding]; other site 290338010338 ACT binding site; other site 290338010339 IMP binding site; other site 290338010340 FtsH protease regulator HflC; Provisional; Region: PRK11029 290338010341 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 290338010342 FtsH protease regulator HflK; Provisional; Region: PRK10930 290338010343 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 290338010344 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 290338010345 GTPase HflX; Provisional; Region: PRK11058 290338010346 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290338010347 HflX GTPase family; Region: HflX; cd01878 290338010348 G1 box; other site 290338010349 GTP/Mg2+ binding site [chemical binding]; other site 290338010350 Switch I region; other site 290338010351 G2 box; other site 290338010352 G3 box; other site 290338010353 Switch II region; other site 290338010354 G4 box; other site 290338010355 G5 box; other site 290338010356 bacterial Hfq-like; Region: Hfq; cd01716 290338010357 hexamer interface [polypeptide binding]; other site 290338010358 Sm1 motif; other site 290338010359 RNA binding site [nucleotide binding]; other site 290338010360 Sm2 motif; other site 290338010361 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 290338010362 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290338010363 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 290338010364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338010365 ATP binding site [chemical binding]; other site 290338010366 Mg2+ binding site [ion binding]; other site 290338010367 G-X-G motif; other site 290338010368 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 290338010369 ATP binding site [chemical binding]; other site 290338010370 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 290338010371 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 290338010372 AMIN domain; Region: AMIN; pfam11741 290338010373 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290338010374 active site 290338010375 metal binding site [ion binding]; metal-binding site 290338010376 ADP-binding protein; Provisional; Region: PRK10646 290338010377 putative carbohydrate kinase; Provisional; Region: PRK10565 290338010378 Uncharacterized conserved protein [Function unknown]; Region: COG0062 290338010379 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290338010380 putative substrate binding site [chemical binding]; other site 290338010381 putative ATP binding site [chemical binding]; other site 290338010382 epoxyqueuosine reductase; Region: TIGR00276 290338010383 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 290338010384 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 290338010385 catalytic site [active] 290338010386 putative active site [active] 290338010387 putative substrate binding site [chemical binding]; other site 290338010388 dimer interface [polypeptide binding]; other site 290338010389 GTPase RsgA; Reviewed; Region: PRK12288 290338010390 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290338010391 RNA binding site [nucleotide binding]; other site 290338010392 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290338010393 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290338010394 GTP/Mg2+ binding site [chemical binding]; other site 290338010395 G4 box; other site 290338010396 G5 box; other site 290338010397 G1 box; other site 290338010398 Switch I region; other site 290338010399 G2 box; other site 290338010400 G3 box; other site 290338010401 Switch II region; other site 290338010402 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 290338010403 putative mechanosensitive channel protein; Provisional; Region: PRK10929 290338010404 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 290338010405 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290338010406 inner membrane transporter YjeM; Provisional; Region: PRK15238 290338010407 poxB regulator PoxA; Provisional; Region: PRK09350 290338010408 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290338010409 motif 1; other site 290338010410 dimer interface [polypeptide binding]; other site 290338010411 active site 290338010412 motif 2; other site 290338010413 motif 3; other site 290338010414 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 290338010415 L-aspartate oxidase; Provisional; Region: PRK06175 290338010416 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290338010417 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 290338010418 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290338010419 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 290338010420 D-subunit interface [polypeptide binding]; other site 290338010421 Iron-sulfur protein interface; other site 290338010422 proximal quinone binding site [chemical binding]; other site 290338010423 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 290338010424 Iron-sulfur protein interface; other site 290338010425 proximal quinone binding site [chemical binding]; other site 290338010426 C-subunit interface; other site 290338010427 distal quinone binding site; other site 290338010428 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 290338010429 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 290338010430 multidrug efflux system protein; Provisional; Region: PRK11431 290338010431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338010432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338010433 DNA binding residues [nucleotide binding] 290338010434 dimerization interface [polypeptide binding]; other site 290338010435 entericidin A; Provisional; Region: PRK09810 290338010436 elongation factor P; Validated; Region: PRK00529 290338010437 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290338010438 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290338010439 RNA binding site [nucleotide binding]; other site 290338010440 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290338010441 RNA binding site [nucleotide binding]; other site 290338010442 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 290338010443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338010444 FeS/SAM binding site; other site 290338010445 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 290338010446 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290338010447 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290338010448 ring oligomerisation interface [polypeptide binding]; other site 290338010449 ATP/Mg binding site [chemical binding]; other site 290338010450 stacking interactions; other site 290338010451 hinge regions; other site 290338010452 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290338010453 oligomerisation interface [polypeptide binding]; other site 290338010454 mobile loop; other site 290338010455 roof hairpin; other site 290338010456 putative transporter; Provisional; Region: PRK11021 290338010457 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 290338010458 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290338010459 Aspartase; Region: Aspartase; cd01357 290338010460 active sites [active] 290338010461 tetramer interface [polypeptide binding]; other site 290338010462 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 290338010463 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 290338010464 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 290338010465 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 290338010466 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 290338010467 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290338010468 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 290338010469 DsbD alpha interface [polypeptide binding]; other site 290338010470 catalytic residues [active] 290338010471 putative transcriptional regulator; Provisional; Region: PRK11640 290338010472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338010473 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 290338010474 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 290338010475 Int/Topo IB signature motif; other site 290338010476 tyrosine recombinase; Provisional; Region: PRK09871 290338010477 active site 290338010478 DNA binding site [nucleotide binding] 290338010479 Int/Topo IB signature motif; other site 290338010480 Fimbrial protein; Region: Fimbrial; cl01416 290338010481 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338010482 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 290338010483 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338010484 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338010485 outer membrane usher protein; Provisional; Region: PRK15193 290338010486 PapC N-terminal domain; Region: PapC_N; pfam13954 290338010487 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338010488 PapC C-terminal domain; Region: PapC_C; pfam13953 290338010489 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338010490 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338010491 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 290338010492 mannosyl binding site [chemical binding]; other site 290338010493 Fimbrial protein; Region: Fimbrial; cl01416 290338010494 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338010495 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290338010496 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338010497 dimer interface [polypeptide binding]; other site 290338010498 putative CheW interface [polypeptide binding]; other site 290338010499 malate dehydrogenase; Provisional; Region: PRK13529 290338010500 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290338010501 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 290338010502 NAD(P) binding site [chemical binding]; other site 290338010503 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 290338010504 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 290338010505 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290338010506 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338010507 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338010508 putative active site [active] 290338010509 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 290338010510 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 290338010511 tetramer interface [polypeptide binding]; other site 290338010512 active site 290338010513 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 290338010514 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 290338010515 trimer interface [polypeptide binding]; other site 290338010516 eyelet of channel; other site 290338010517 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 290338010518 active site 290338010519 catalytic triad [active] 290338010520 oxyanion hole [active] 290338010521 2-isopropylmalate synthase; Region: PLN02321 290338010522 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 290338010523 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338010524 N-terminal plug; other site 290338010525 ligand-binding site [chemical binding]; other site 290338010526 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338010527 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338010528 DNA binding site [nucleotide binding] 290338010529 domain linker motif; other site 290338010530 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290338010531 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 290338010532 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290338010533 classical (c) SDRs; Region: SDR_c; cd05233 290338010534 NAD(P) binding site [chemical binding]; other site 290338010535 active site 290338010536 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 290338010537 DctM-like transporters; Region: DctM; pfam06808 290338010538 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 290338010539 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 290338010540 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 290338010541 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290338010542 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290338010543 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290338010544 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 290338010545 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 290338010546 Glucuronate isomerase; Region: UxaC; pfam02614 290338010547 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 290338010548 mannonate dehydratase; Provisional; Region: PRK03906 290338010549 mannonate dehydratase; Region: uxuA; TIGR00695 290338010550 Hemin uptake protein hemP; Region: hemP; cl10043 290338010551 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 290338010552 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338010553 N-terminal plug; other site 290338010554 ligand-binding site [chemical binding]; other site 290338010555 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 290338010556 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 290338010557 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 290338010558 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 290338010559 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290338010560 putative hemin binding site; other site 290338010561 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338010562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338010563 ABC-ATPase subunit interface; other site 290338010564 dimer interface [polypeptide binding]; other site 290338010565 putative PBP binding regions; other site 290338010566 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 290338010567 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338010568 Walker A/P-loop; other site 290338010569 ATP binding site [chemical binding]; other site 290338010570 Q-loop/lid; other site 290338010571 ABC transporter signature motif; other site 290338010572 Walker B; other site 290338010573 D-loop; other site 290338010574 H-loop/switch region; other site 290338010575 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 290338010576 sensory histidine kinase DcuS; Provisional; Region: PRK11086 290338010577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338010578 ATP binding site [chemical binding]; other site 290338010579 Mg2+ binding site [ion binding]; other site 290338010580 G-X-G motif; other site 290338010581 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 290338010582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338010583 active site 290338010584 phosphorylation site [posttranslational modification] 290338010585 intermolecular recognition site; other site 290338010586 dimerization interface [polypeptide binding]; other site 290338010587 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 290338010588 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 290338010589 fumarate hydratase; Provisional; Region: PRK15389 290338010590 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 290338010591 Fumarase C-terminus; Region: Fumerase_C; pfam05683 290338010592 putative metal dependent hydrolase; Provisional; Region: PRK11598 290338010593 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 290338010594 Sulfatase; Region: Sulfatase; pfam00884 290338010595 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 290338010596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338010597 active site 290338010598 phosphorylation site [posttranslational modification] 290338010599 intermolecular recognition site; other site 290338010600 dimerization interface [polypeptide binding]; other site 290338010601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338010602 DNA binding site [nucleotide binding] 290338010603 sensor protein BasS/PmrB; Provisional; Region: PRK10755 290338010604 HAMP domain; Region: HAMP; pfam00672 290338010605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338010606 dimer interface [polypeptide binding]; other site 290338010607 phosphorylation site [posttranslational modification] 290338010608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338010609 ATP binding site [chemical binding]; other site 290338010610 Mg2+ binding site [ion binding]; other site 290338010611 G-X-G motif; other site 290338010612 proline/glycine betaine transporter; Provisional; Region: PRK10642 290338010613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338010614 putative substrate translocation pore; other site 290338010615 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 290338010616 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 290338010617 YjcZ-like protein; Region: YjcZ; pfam13990 290338010618 hypothetical protein; Provisional; Region: PRK09866 290338010619 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290338010620 G1 box; other site 290338010621 GTP/Mg2+ binding site [chemical binding]; other site 290338010622 G2 box; other site 290338010623 Switch I region; other site 290338010624 G3 box; other site 290338010625 Switch II region; other site 290338010626 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 290338010627 G2 box; other site 290338010628 Switch I region; other site 290338010629 G3 box; other site 290338010630 Switch II region; other site 290338010631 G4 box; other site 290338010632 G5 box; other site 290338010633 hypothetical protein; Provisional; Region: PRK10220 290338010634 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 290338010635 PhnA protein; Region: PhnA; pfam03831 290338010636 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290338010637 dimer interface [polypeptide binding]; other site 290338010638 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290338010639 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 290338010640 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 290338010641 Walker A/P-loop; other site 290338010642 ATP binding site [chemical binding]; other site 290338010643 Q-loop/lid; other site 290338010644 ABC transporter signature motif; other site 290338010645 Walker B; other site 290338010646 D-loop; other site 290338010647 H-loop/switch region; other site 290338010648 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 290338010649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338010650 substrate binding pocket [chemical binding]; other site 290338010651 membrane-bound complex binding site; other site 290338010652 hinge residues; other site 290338010653 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 290338010654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338010655 dimer interface [polypeptide binding]; other site 290338010656 conserved gate region; other site 290338010657 putative PBP binding loops; other site 290338010658 ABC-ATPase subunit interface; other site 290338010659 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 290338010660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338010661 DNA-binding site [nucleotide binding]; DNA binding site 290338010662 UTRA domain; Region: UTRA; pfam07702 290338010663 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 290338010664 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 290338010665 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 290338010666 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 290338010667 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 290338010668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338010669 Walker A/P-loop; other site 290338010670 ATP binding site [chemical binding]; other site 290338010671 Q-loop/lid; other site 290338010672 ABC transporter signature motif; other site 290338010673 Walker B; other site 290338010674 D-loop; other site 290338010675 H-loop/switch region; other site 290338010676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338010677 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 290338010678 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290338010679 Walker A/P-loop; other site 290338010680 ATP binding site [chemical binding]; other site 290338010681 Q-loop/lid; other site 290338010682 ABC transporter signature motif; other site 290338010683 Walker B; other site 290338010684 D-loop; other site 290338010685 H-loop/switch region; other site 290338010686 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 290338010687 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290338010688 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 290338010689 active site 290338010690 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 290338010691 active site 290338010692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338010693 Coenzyme A binding pocket [chemical binding]; other site 290338010694 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290338010695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 290338010696 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 290338010697 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 290338010698 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338010699 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338010700 putative active site [active] 290338010701 D-allose transporter subunit; Provisional; Region: PRK09701 290338010702 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290338010703 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 290338010704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338010705 Walker A/P-loop; other site 290338010706 ATP binding site [chemical binding]; other site 290338010707 Q-loop/lid; other site 290338010708 ABC transporter signature motif; other site 290338010709 Walker B; other site 290338010710 D-loop; other site 290338010711 H-loop/switch region; other site 290338010712 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338010713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338010714 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338010715 TM-ABC transporter signature motif; other site 290338010716 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 290338010717 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290338010718 hexamer interface [polypeptide binding]; other site 290338010719 metal binding site [ion binding]; metal-binding site 290338010720 substrate binding site [chemical binding]; other site 290338010721 D-allose kinase; Provisional; Region: PRK09698 290338010722 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338010723 nucleotide binding site [chemical binding]; other site 290338010724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290338010725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338010726 dimerization interface [polypeptide binding]; other site 290338010727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338010728 dimer interface [polypeptide binding]; other site 290338010729 phosphorylation site [posttranslational modification] 290338010730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338010731 ATP binding site [chemical binding]; other site 290338010732 Mg2+ binding site [ion binding]; other site 290338010733 G-X-G motif; other site 290338010734 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290338010735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338010736 active site 290338010737 phosphorylation site [posttranslational modification] 290338010738 intermolecular recognition site; other site 290338010739 dimerization interface [polypeptide binding]; other site 290338010740 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290338010741 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338010742 Walker A/P-loop; other site 290338010743 ATP binding site [chemical binding]; other site 290338010744 Q-loop/lid; other site 290338010745 ABC transporter signature motif; other site 290338010746 Walker B; other site 290338010747 D-loop; other site 290338010748 H-loop/switch region; other site 290338010749 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338010750 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338010751 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338010752 TM-ABC transporter signature motif; other site 290338010753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 290338010754 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 290338010755 putative ligand binding site [chemical binding]; other site 290338010756 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 290338010757 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290338010758 intersubunit interface [polypeptide binding]; other site 290338010759 active site 290338010760 zinc binding site [ion binding]; other site 290338010761 Na+ binding site [ion binding]; other site 290338010762 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 290338010763 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338010764 substrate binding site [chemical binding]; other site 290338010765 ATP binding site [chemical binding]; other site 290338010766 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290338010767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338010768 active site 290338010769 phosphorylation site [posttranslational modification] 290338010770 intermolecular recognition site; other site 290338010771 dimerization interface [polypeptide binding]; other site 290338010772 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338010773 DNA binding site [nucleotide binding] 290338010774 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338010775 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338010776 molybdopterin cofactor binding site; other site 290338010777 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 290338010778 molybdopterin cofactor binding site; other site 290338010779 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 290338010780 Sel1-like repeats; Region: SEL1; smart00671 290338010781 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 290338010782 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338010783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 290338010784 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 290338010785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338010786 TPR motif; other site 290338010787 binding surface 290338010788 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 290338010789 heme lyase subunit NrfE; Provisional; Region: PRK10369 290338010790 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 290338010791 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 290338010792 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 290338010793 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 290338010794 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 290338010795 acetyl-CoA synthetase; Provisional; Region: PRK00174 290338010796 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290338010797 active site 290338010798 CoA binding site [chemical binding]; other site 290338010799 acyl-activating enzyme (AAE) consensus motif; other site 290338010800 AMP binding site [chemical binding]; other site 290338010801 acetate binding site [chemical binding]; other site 290338010802 Predicted membrane protein [Function unknown]; Region: COG3162 290338010803 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290338010804 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290338010805 Na binding site [ion binding]; other site 290338010806 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 290338010807 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 290338010808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338010809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338010810 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 290338010811 putative dimerization interface [polypeptide binding]; other site 290338010812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 290338010813 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 290338010814 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290338010815 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290338010816 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 290338010817 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 290338010818 putative C-terminal domain interface [polypeptide binding]; other site 290338010819 putative GSH binding site (G-site) [chemical binding]; other site 290338010820 putative dimer interface [polypeptide binding]; other site 290338010821 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 290338010822 putative N-terminal domain interface [polypeptide binding]; other site 290338010823 putative dimer interface [polypeptide binding]; other site 290338010824 putative substrate binding pocket (H-site) [chemical binding]; other site 290338010825 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 290338010826 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 290338010827 DNA binding residues [nucleotide binding] 290338010828 dimer interface [polypeptide binding]; other site 290338010829 [2Fe-2S] cluster binding site [ion binding]; other site 290338010830 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 290338010831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338010832 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 290338010833 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 290338010834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338010835 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 290338010836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338010837 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 290338010838 fec operon regulator FecR; Reviewed; Region: PRK09774 290338010839 FecR protein; Region: FecR; pfam04773 290338010840 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 290338010841 Secretin and TonB N terminus short domain; Region: STN; smart00965 290338010842 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290338010843 N-terminal plug; other site 290338010844 ligand-binding site [chemical binding]; other site 290338010845 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 290338010846 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 290338010847 siderophore binding site; other site 290338010848 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338010849 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338010850 dimer interface [polypeptide binding]; other site 290338010851 ABC-ATPase subunit interface; other site 290338010852 putative PBP binding regions; other site 290338010853 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290338010854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338010855 ABC-ATPase subunit interface; other site 290338010856 dimer interface [polypeptide binding]; other site 290338010857 putative PBP binding regions; other site 290338010858 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 290338010859 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290338010860 Walker A/P-loop; other site 290338010861 ATP binding site [chemical binding]; other site 290338010862 Q-loop/lid; other site 290338010863 ABC transporter signature motif; other site 290338010864 Walker B; other site 290338010865 D-loop; other site 290338010866 H-loop/switch region; other site 290338010867 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 290338010868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290338010869 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290338010870 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290338010871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338010872 motif II; other site 290338010873 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290338010874 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338010875 Ligand Binding Site [chemical binding]; other site 290338010876 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290338010877 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290338010878 dimer interface [polypeptide binding]; other site 290338010879 ssDNA binding site [nucleotide binding]; other site 290338010880 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290338010881 putative single-stranded DNA-binding protein; Region: PHA01740 290338010882 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290338010883 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290338010884 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290338010885 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290338010886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 290338010887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338010888 active site 290338010889 motif I; other site 290338010890 motif II; other site 290338010891 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 290338010892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 290338010893 dimer interface [polypeptide binding]; other site 290338010894 phosphorylation site [posttranslational modification] 290338010895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338010896 ATP binding site [chemical binding]; other site 290338010897 Mg2+ binding site [ion binding]; other site 290338010898 G-X-G motif; other site 290338010899 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290338010900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338010901 active site 290338010902 phosphorylation site [posttranslational modification] 290338010903 intermolecular recognition site; other site 290338010904 dimerization interface [polypeptide binding]; other site 290338010905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338010906 Walker A motif; other site 290338010907 ATP binding site [chemical binding]; other site 290338010908 Walker B motif; other site 290338010909 arginine finger; other site 290338010910 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338010911 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 290338010912 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290338010913 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338010914 transmembrane helices; other site 290338010915 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290338010916 CoA binding domain; Region: CoA_binding; smart00881 290338010917 CoA-ligase; Region: Ligase_CoA; pfam00549 290338010918 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290338010919 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290338010920 CoA-ligase; Region: Ligase_CoA; pfam00549 290338010921 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 290338010922 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 290338010923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338010924 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290338010925 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 290338010926 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290338010927 E3 interaction surface; other site 290338010928 lipoyl attachment site [posttranslational modification]; other site 290338010929 e3 binding domain; Region: E3_binding; pfam02817 290338010930 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290338010931 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 290338010932 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290338010933 TPP-binding site [chemical binding]; other site 290338010934 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 290338010935 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 290338010936 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338010937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338010938 homodimer interface [polypeptide binding]; other site 290338010939 catalytic residue [active] 290338010940 alanine racemase; Reviewed; Region: alr; PRK00053 290338010941 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 290338010942 active site 290338010943 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290338010944 substrate binding site [chemical binding]; other site 290338010945 catalytic residues [active] 290338010946 dimer interface [polypeptide binding]; other site 290338010947 replicative DNA helicase; Provisional; Region: PRK08006 290338010948 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290338010949 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290338010950 Walker A motif; other site 290338010951 ATP binding site [chemical binding]; other site 290338010952 Walker B motif; other site 290338010953 DNA binding loops [nucleotide binding] 290338010954 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 290338010955 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 290338010956 NADP binding site [chemical binding]; other site 290338010957 dimer interface [polypeptide binding]; other site 290338010958 phage shock protein G; Reviewed; Region: pspG; PRK09459 290338010959 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 290338010960 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290338010961 FMN binding site [chemical binding]; other site 290338010962 active site 290338010963 catalytic residues [active] 290338010964 substrate binding site [chemical binding]; other site 290338010965 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 290338010966 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 290338010967 Protein of unknown function (DUF796); Region: DUF796; cl01226 290338010968 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 290338010969 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290338010970 metal binding site 2 [ion binding]; metal-binding site 290338010971 putative DNA binding helix; other site 290338010972 metal binding site 1 [ion binding]; metal-binding site 290338010973 dimer interface [polypeptide binding]; other site 290338010974 structural Zn2+ binding site [ion binding]; other site 290338010975 hypothetical protein; Provisional; Region: PRK10428 290338010976 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 290338010977 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 290338010978 LexA repressor; Validated; Region: PRK00215 290338010979 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 290338010980 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290338010981 Catalytic site [active] 290338010982 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 290338010983 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 290338010984 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 290338010985 putative acyl-acceptor binding pocket; other site 290338010986 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 290338010987 UbiA prenyltransferase family; Region: UbiA; pfam01040 290338010988 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 290338010989 maltose regulon periplasmic protein; Provisional; Region: PRK10564 290338010990 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 290338010991 trimer interface; other site 290338010992 sugar binding site [chemical binding]; other site 290338010993 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 290338010994 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290338010995 Walker A/P-loop; other site 290338010996 ATP binding site [chemical binding]; other site 290338010997 Q-loop/lid; other site 290338010998 ABC transporter signature motif; other site 290338010999 Walker B; other site 290338011000 D-loop; other site 290338011001 H-loop/switch region; other site 290338011002 TOBE domain; Region: TOBE_2; pfam08402 290338011003 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 290338011004 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 290338011005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290338011006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338011007 dimer interface [polypeptide binding]; other site 290338011008 conserved gate region; other site 290338011009 putative PBP binding loops; other site 290338011010 ABC-ATPase subunit interface; other site 290338011011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290338011012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338011013 dimer interface [polypeptide binding]; other site 290338011014 conserved gate region; other site 290338011015 putative PBP binding loops; other site 290338011016 ABC-ATPase subunit interface; other site 290338011017 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 290338011018 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 290338011019 putative trimer interface [polypeptide binding]; other site 290338011020 putative active site [active] 290338011021 putative substrate binding site [chemical binding]; other site 290338011022 putative CoA binding site [chemical binding]; other site 290338011023 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 290338011024 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 290338011025 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 290338011026 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 290338011027 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 290338011028 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290338011029 active site 290338011030 dimer interface [polypeptide binding]; other site 290338011031 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 290338011032 dimer interface [polypeptide binding]; other site 290338011033 active site 290338011034 aspartate kinase III; Validated; Region: PRK09084 290338011035 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 290338011036 nucleotide binding site [chemical binding]; other site 290338011037 substrate binding site [chemical binding]; other site 290338011038 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290338011039 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 290338011040 dimer interface [polypeptide binding]; other site 290338011041 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 290338011042 Sodium Bile acid symporter family; Region: SBF; pfam01758 290338011043 hypothetical protein; Provisional; Region: PRK10515 290338011044 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 290338011045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338011046 RNA binding surface [nucleotide binding]; other site 290338011047 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 290338011048 probable active site [active] 290338011049 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 290338011050 active site pocket [active] 290338011051 oxyanion hole [active] 290338011052 catalytic triad [active] 290338011053 active site nucleophile [active] 290338011054 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 290338011055 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290338011056 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 290338011057 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 290338011058 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 290338011059 substrate binding pocket [chemical binding]; other site 290338011060 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 290338011061 B12 binding site [chemical binding]; other site 290338011062 cobalt ligand [ion binding]; other site 290338011063 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 290338011064 transcriptional repressor IclR; Provisional; Region: PRK11569 290338011065 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290338011066 Bacterial transcriptional regulator; Region: IclR; pfam01614 290338011067 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 290338011068 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 290338011069 isocitrate lyase; Provisional; Region: PRK15063 290338011070 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290338011071 tetramer interface [polypeptide binding]; other site 290338011072 active site 290338011073 Mg2+/Mn2+ binding site [ion binding]; other site 290338011074 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290338011075 malate synthase A; Region: malate_syn_A; TIGR01344 290338011076 active site 290338011077 homoserine O-succinyltransferase; Provisional; Region: PRK05368 290338011078 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 290338011079 proposed active site lysine [active] 290338011080 conserved cys residue [active] 290338011081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290338011082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338011083 Coenzyme A binding pocket [chemical binding]; other site 290338011084 protein disaggregation chaperone; Provisional; Region: PRK10865 290338011085 Clp amino terminal domain; Region: Clp_N; pfam02861 290338011086 Clp amino terminal domain; Region: Clp_N; pfam02861 290338011087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338011088 Walker A motif; other site 290338011089 ATP binding site [chemical binding]; other site 290338011090 Walker B motif; other site 290338011091 arginine finger; other site 290338011092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338011093 Walker A motif; other site 290338011094 ATP binding site [chemical binding]; other site 290338011095 Walker B motif; other site 290338011096 arginine finger; other site 290338011097 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290338011098 hypothetical protein; Provisional; Region: PRK10723 290338011099 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 290338011100 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 290338011101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338011102 RNA binding surface [nucleotide binding]; other site 290338011103 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290338011104 active site 290338011105 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 290338011106 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 290338011107 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290338011108 30S subunit binding site; other site 290338011109 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 290338011110 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 290338011111 Prephenate dehydratase; Region: PDT; pfam00800 290338011112 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290338011113 putative L-Phe binding site [chemical binding]; other site 290338011114 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 290338011115 Chorismate mutase type II; Region: CM_2; cl00693 290338011116 prephenate dehydrogenase; Validated; Region: PRK08507 290338011117 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 290338011118 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290338011119 lipoprotein; Provisional; Region: PRK11443 290338011120 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 290338011121 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 290338011122 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 290338011123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338011124 metal binding site [ion binding]; metal-binding site 290338011125 active site 290338011126 I-site; other site 290338011127 putative outer membrane lipoprotein; Provisional; Region: PRK09967 290338011128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290338011129 ligand binding site [chemical binding]; other site 290338011130 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 290338011131 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 290338011132 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 290338011133 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 290338011134 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 290338011135 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 290338011136 RimM N-terminal domain; Region: RimM; pfam01782 290338011137 PRC-barrel domain; Region: PRC; pfam05239 290338011138 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 290338011139 signal recognition particle protein; Provisional; Region: PRK10867 290338011140 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 290338011141 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290338011142 P loop; other site 290338011143 GTP binding site [chemical binding]; other site 290338011144 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290338011145 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 290338011146 hypothetical protein; Provisional; Region: PRK11573 290338011147 Domain of unknown function DUF21; Region: DUF21; pfam01595 290338011148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290338011149 Transporter associated domain; Region: CorC_HlyC; smart01091 290338011150 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 290338011151 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290338011152 dimer interface [polypeptide binding]; other site 290338011153 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290338011154 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 290338011155 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 290338011156 recombination and repair protein; Provisional; Region: PRK10869 290338011157 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290338011158 Walker A/P-loop; other site 290338011159 ATP binding site [chemical binding]; other site 290338011160 Q-loop/lid; other site 290338011161 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290338011162 Q-loop/lid; other site 290338011163 ABC transporter signature motif; other site 290338011164 Walker B; other site 290338011165 D-loop; other site 290338011166 H-loop/switch region; other site 290338011167 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 290338011168 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 290338011169 hypothetical protein; Validated; Region: PRK01777 290338011170 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 290338011171 putative coenzyme Q binding site [chemical binding]; other site 290338011172 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290338011173 SmpB-tmRNA interface; other site 290338011174 integrase; Provisional; Region: PRK09692 290338011175 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 290338011176 active site 290338011177 Int/Topo IB signature motif; other site 290338011178 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290338011179 Part of AAA domain; Region: AAA_19; pfam13245 290338011180 Family description; Region: UvrD_C_2; pfam13538 290338011181 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 290338011182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338011183 Walker A/P-loop; other site 290338011184 ATP binding site [chemical binding]; other site 290338011185 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 290338011186 putative active site [active] 290338011187 putative metal-binding site [ion binding]; other site 290338011188 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 290338011189 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290338011190 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290338011191 lipoprotein NlpI; Provisional; Region: PRK11189 290338011192 nucleotide kinase; Region: PLN02842 290338011193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 290338011194 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290338011195 active site 290338011196 catalytic residues [active] 290338011197 DNA binding site [nucleotide binding] 290338011198 Int/Topo IB signature motif; other site 290338011199 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290338011200 active site 290338011201 catalytic residues [active] 290338011202 DNA binding site [nucleotide binding] 290338011203 Int/Topo IB signature motif; other site 290338011204 DinI-like family; Region: DinI; pfam06183 290338011205 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 290338011206 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 290338011207 intersubunit interface [polypeptide binding]; other site 290338011208 active site 290338011209 Zn2+ binding site [ion binding]; other site 290338011210 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 290338011211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338011212 motif II; other site 290338011213 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 290338011214 Cupin domain; Region: Cupin_2; cl17218 290338011215 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 290338011216 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 290338011217 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 290338011218 Phosphotransferase enzyme family; Region: APH; pfam01636 290338011219 Uncharacterized conserved protein [Function unknown]; Region: COG5276 290338011220 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 290338011221 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290338011222 putative ligand binding site [chemical binding]; other site 290338011223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338011224 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338011225 TM-ABC transporter signature motif; other site 290338011226 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290338011227 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338011228 Walker A/P-loop; other site 290338011229 ATP binding site [chemical binding]; other site 290338011230 Q-loop/lid; other site 290338011231 ABC transporter signature motif; other site 290338011232 Walker B; other site 290338011233 D-loop; other site 290338011234 H-loop/switch region; other site 290338011235 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338011236 PAS fold; Region: PAS_3; pfam08447 290338011237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338011238 putative active site [active] 290338011239 heme pocket [chemical binding]; other site 290338011240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290338011241 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290338011242 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338011243 dimer interface [polypeptide binding]; other site 290338011244 putative CheW interface [polypeptide binding]; other site 290338011245 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 290338011246 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290338011247 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338011248 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290338011249 substrate binding site [chemical binding]; other site 290338011250 ATP binding site [chemical binding]; other site 290338011251 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 290338011252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 290338011253 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290338011254 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338011255 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338011256 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338011257 TM-ABC transporter signature motif; other site 290338011258 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290338011259 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338011260 Walker A/P-loop; other site 290338011261 ATP binding site [chemical binding]; other site 290338011262 Q-loop/lid; other site 290338011263 ABC transporter signature motif; other site 290338011264 Walker B; other site 290338011265 D-loop; other site 290338011266 H-loop/switch region; other site 290338011267 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338011268 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290338011269 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290338011270 ligand binding site [chemical binding]; other site 290338011271 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290338011272 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338011273 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290338011274 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 290338011275 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290338011276 PYR/PP interface [polypeptide binding]; other site 290338011277 dimer interface [polypeptide binding]; other site 290338011278 TPP binding site [chemical binding]; other site 290338011279 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290338011280 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 290338011281 TPP-binding site; other site 290338011282 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290338011283 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290338011284 tetrameric interface [polypeptide binding]; other site 290338011285 NAD binding site [chemical binding]; other site 290338011286 catalytic residues [active] 290338011287 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290338011288 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338011289 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338011290 putative active site [active] 290338011291 RloB-like protein; Region: RloB; pfam13707 290338011292 AAA domain; Region: AAA_21; pfam13304 290338011293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 290338011294 ABC transporter signature motif; other site 290338011295 Walker B; other site 290338011296 D-loop; other site 290338011297 H-loop/switch region; other site 290338011298 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 290338011299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290338011300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 290338011301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338011302 dimer interface [polypeptide binding]; other site 290338011303 phosphorylation site [posttranslational modification] 290338011304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338011305 ATP binding site [chemical binding]; other site 290338011306 Mg2+ binding site [ion binding]; other site 290338011307 G-X-G motif; other site 290338011308 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 290338011309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338011310 active site 290338011311 phosphorylation site [posttranslational modification] 290338011312 intermolecular recognition site; other site 290338011313 dimerization interface [polypeptide binding]; other site 290338011314 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338011315 DNA binding site [nucleotide binding] 290338011316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 290338011317 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 290338011318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 290338011319 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 290338011320 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 290338011321 substrate binding pocket [chemical binding]; other site 290338011322 active site 290338011323 iron coordination sites [ion binding]; other site 290338011324 Predicted dehydrogenase [General function prediction only]; Region: COG0579 290338011325 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290338011326 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 290338011327 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290338011328 tetramerization interface [polypeptide binding]; other site 290338011329 NAD(P) binding site [chemical binding]; other site 290338011330 catalytic residues [active] 290338011331 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 290338011332 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338011333 inhibitor-cofactor binding pocket; inhibition site 290338011334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338011335 catalytic residue [active] 290338011336 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 290338011337 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 290338011338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338011339 DNA-binding site [nucleotide binding]; DNA binding site 290338011340 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290338011341 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 290338011342 bacterial OsmY and nodulation domain; Region: BON; smart00749 290338011343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338011344 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290338011345 active site residue [active] 290338011346 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 290338011347 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 290338011348 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 290338011349 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 290338011350 hypothetical protein; Provisional; Region: PRK10556 290338011351 hypothetical protein; Provisional; Region: PRK10132 290338011352 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290338011353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338011354 DNA-binding site [nucleotide binding]; DNA binding site 290338011355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338011356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338011357 homodimer interface [polypeptide binding]; other site 290338011358 catalytic residue [active] 290338011359 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290338011360 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290338011361 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290338011362 catalytic residues [active] 290338011363 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 290338011364 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 290338011365 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 290338011366 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290338011367 active site 290338011368 dimer interface [polypeptide binding]; other site 290338011369 catalytic residues [active] 290338011370 effector binding site; other site 290338011371 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290338011372 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 290338011373 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290338011374 dimer interface [polypeptide binding]; other site 290338011375 putative radical transfer pathway; other site 290338011376 diiron center [ion binding]; other site 290338011377 tyrosyl radical; other site 290338011378 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 290338011379 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 290338011380 Walker A/P-loop; other site 290338011381 ATP binding site [chemical binding]; other site 290338011382 Q-loop/lid; other site 290338011383 ABC transporter signature motif; other site 290338011384 Walker B; other site 290338011385 D-loop; other site 290338011386 H-loop/switch region; other site 290338011387 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 290338011388 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 290338011389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338011390 dimer interface [polypeptide binding]; other site 290338011391 conserved gate region; other site 290338011392 putative PBP binding loops; other site 290338011393 ABC-ATPase subunit interface; other site 290338011394 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 290338011395 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290338011396 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290338011397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011398 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 290338011399 putative L-valine exporter; Provisional; Region: PRK10408 290338011400 transcriptional repressor MprA; Provisional; Region: PRK10870 290338011401 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290338011402 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 290338011403 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338011404 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338011405 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290338011406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011407 putative substrate translocation pore; other site 290338011408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011409 S-ribosylhomocysteinase; Provisional; Region: PRK02260 290338011410 glutamate--cysteine ligase; Provisional; Region: PRK02107 290338011411 Predicted membrane protein [Function unknown]; Region: COG1238 290338011412 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 290338011413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338011414 motif II; other site 290338011415 carbon storage regulator; Provisional; Region: PRK01712 290338011416 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290338011417 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 290338011418 motif 1; other site 290338011419 active site 290338011420 motif 2; other site 290338011421 motif 3; other site 290338011422 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 290338011423 DHHA1 domain; Region: DHHA1; pfam02272 290338011424 recombination regulator RecX; Reviewed; Region: recX; PRK00117 290338011425 recombinase A; Provisional; Region: recA; PRK09354 290338011426 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290338011427 hexamer interface [polypeptide binding]; other site 290338011428 Walker A motif; other site 290338011429 ATP binding site [chemical binding]; other site 290338011430 Walker B motif; other site 290338011431 hypothetical protein; Validated; Region: PRK03661 290338011432 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 290338011433 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290338011434 metal binding site [ion binding]; metal-binding site 290338011435 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338011436 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338011437 ABC-ATPase subunit interface; other site 290338011438 dimer interface [polypeptide binding]; other site 290338011439 putative PBP binding regions; other site 290338011440 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290338011441 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290338011442 Transglycosylase SLT domain; Region: SLT_2; pfam13406 290338011443 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338011444 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338011445 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 290338011446 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 290338011447 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 290338011448 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 290338011449 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 290338011450 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 290338011451 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 290338011452 putative NAD(P) binding site [chemical binding]; other site 290338011453 active site 290338011454 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 290338011455 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 290338011456 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290338011457 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338011458 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 290338011459 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 290338011460 putative active site [active] 290338011461 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 290338011462 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 290338011463 GAF domain; Region: GAF; pfam01590 290338011464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338011465 Walker A motif; other site 290338011466 ATP binding site [chemical binding]; other site 290338011467 Walker B motif; other site 290338011468 arginine finger; other site 290338011469 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 290338011470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290338011471 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 290338011472 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290338011473 iron binding site [ion binding]; other site 290338011474 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 290338011475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338011476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338011477 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 290338011478 Acylphosphatase; Region: Acylphosphatase; pfam00708 290338011479 HypF finger; Region: zf-HYPF; pfam07503 290338011480 HypF finger; Region: zf-HYPF; pfam07503 290338011481 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 290338011482 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 290338011483 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 290338011484 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338011485 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338011486 DNA binding site [nucleotide binding] 290338011487 domain linker motif; other site 290338011488 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290338011489 dimerization interface (closed form) [polypeptide binding]; other site 290338011490 ligand binding site [chemical binding]; other site 290338011491 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 290338011492 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338011493 active site turn [active] 290338011494 phosphorylation site [posttranslational modification] 290338011495 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 290338011496 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 290338011497 beta-galactosidase; Region: BGL; TIGR03356 290338011498 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 290338011499 nickel binding site [ion binding]; other site 290338011500 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 290338011501 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 290338011502 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 290338011503 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338011504 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 290338011505 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 290338011506 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 290338011507 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 290338011508 NADH dehydrogenase; Region: NADHdh; cl00469 290338011509 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 290338011510 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290338011511 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 290338011512 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 290338011513 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 290338011514 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 290338011515 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 290338011516 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 290338011517 hydrogenase assembly chaperone; Provisional; Region: PRK10409 290338011518 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 290338011519 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 290338011520 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 290338011521 dimerization interface [polypeptide binding]; other site 290338011522 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 290338011523 ATP binding site [chemical binding]; other site 290338011524 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 290338011525 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290338011526 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290338011527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338011528 Walker A motif; other site 290338011529 ATP binding site [chemical binding]; other site 290338011530 Walker B motif; other site 290338011531 arginine finger; other site 290338011532 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 290338011533 molybdenum-pterin binding domain; Region: Mop; TIGR00638 290338011534 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 290338011535 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 290338011536 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290338011537 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290338011538 metal binding site [ion binding]; metal-binding site 290338011539 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 290338011540 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290338011541 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338011542 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338011543 ABC-ATPase subunit interface; other site 290338011544 dimer interface [polypeptide binding]; other site 290338011545 putative PBP binding regions; other site 290338011546 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290338011547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290338011548 ABC-ATPase subunit interface; other site 290338011549 dimer interface [polypeptide binding]; other site 290338011550 putative PBP binding regions; other site 290338011551 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 290338011552 MutS domain I; Region: MutS_I; pfam01624 290338011553 MutS domain II; Region: MutS_II; pfam05188 290338011554 MutS domain III; Region: MutS_III; pfam05192 290338011555 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 290338011556 Walker A/P-loop; other site 290338011557 ATP binding site [chemical binding]; other site 290338011558 Q-loop/lid; other site 290338011559 ABC transporter signature motif; other site 290338011560 Walker B; other site 290338011561 D-loop; other site 290338011562 H-loop/switch region; other site 290338011563 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 290338011564 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 290338011565 Flavoprotein; Region: Flavoprotein; pfam02441 290338011566 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290338011567 MarR family; Region: MarR; pfam01047 290338011568 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 290338011569 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290338011570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338011571 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290338011572 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290338011573 DNA binding residues [nucleotide binding] 290338011574 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290338011575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290338011576 Peptidase family M23; Region: Peptidase_M23; pfam01551 290338011577 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 290338011578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338011579 S-adenosylmethionine binding site [chemical binding]; other site 290338011580 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 290338011581 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 290338011582 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 290338011583 Permutation of conserved domain; other site 290338011584 active site 290338011585 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 290338011586 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 290338011587 homotrimer interaction site [polypeptide binding]; other site 290338011588 zinc binding site [ion binding]; other site 290338011589 CDP-binding sites; other site 290338011590 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290338011591 substrate binding site; other site 290338011592 dimer interface; other site 290338011593 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 290338011594 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 290338011595 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 290338011596 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 290338011597 ligand-binding site [chemical binding]; other site 290338011598 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 290338011599 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 290338011600 CysD dimerization site [polypeptide binding]; other site 290338011601 G1 box; other site 290338011602 putative GEF interaction site [polypeptide binding]; other site 290338011603 GTP/Mg2+ binding site [chemical binding]; other site 290338011604 Switch I region; other site 290338011605 G2 box; other site 290338011606 G3 box; other site 290338011607 Switch II region; other site 290338011608 G4 box; other site 290338011609 G5 box; other site 290338011610 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 290338011611 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 290338011612 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 290338011613 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290338011614 Active Sites [active] 290338011615 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 290338011616 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 290338011617 metal binding site [ion binding]; metal-binding site 290338011618 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 290338011619 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290338011620 Active Sites [active] 290338011621 sulfite reductase subunit beta; Provisional; Region: PRK13504 290338011622 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290338011623 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290338011624 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 290338011625 Flavodoxin; Region: Flavodoxin_1; pfam00258 290338011626 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 290338011627 FAD binding pocket [chemical binding]; other site 290338011628 FAD binding motif [chemical binding]; other site 290338011629 catalytic residues [active] 290338011630 NAD binding pocket [chemical binding]; other site 290338011631 phosphate binding motif [ion binding]; other site 290338011632 beta-alpha-beta structure motif; other site 290338011633 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290338011634 active site 290338011635 oxidoreductase; Provisional; Region: PRK10015 290338011636 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 290338011637 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 290338011638 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 290338011639 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290338011640 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 290338011641 Ligand Binding Site [chemical binding]; other site 290338011642 Electron transfer flavoprotein domain; Region: ETF; pfam01012 290338011643 benzoate transport; Region: 2A0115; TIGR00895 290338011644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011645 putative substrate translocation pore; other site 290338011646 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290338011647 FAD binding domain; Region: FAD_binding_4; pfam01565 290338011648 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 290338011649 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290338011650 NADP binding site [chemical binding]; other site 290338011651 homodimer interface [polypeptide binding]; other site 290338011652 active site 290338011653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290338011654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011655 putative substrate translocation pore; other site 290338011656 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 290338011657 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290338011658 nucleotide binding site [chemical binding]; other site 290338011659 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 290338011660 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 290338011661 enolase; Provisional; Region: eno; PRK00077 290338011662 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290338011663 dimer interface [polypeptide binding]; other site 290338011664 metal binding site [ion binding]; metal-binding site 290338011665 substrate binding pocket [chemical binding]; other site 290338011666 CTP synthetase; Validated; Region: pyrG; PRK05380 290338011667 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290338011668 Catalytic site [active] 290338011669 active site 290338011670 UTP binding site [chemical binding]; other site 290338011671 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290338011672 active site 290338011673 putative oxyanion hole; other site 290338011674 catalytic triad [active] 290338011675 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 290338011676 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 290338011677 homodimer interface [polypeptide binding]; other site 290338011678 metal binding site [ion binding]; metal-binding site 290338011679 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 290338011680 homodimer interface [polypeptide binding]; other site 290338011681 active site 290338011682 putative chemical substrate binding site [chemical binding]; other site 290338011683 metal binding site [ion binding]; metal-binding site 290338011684 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 290338011685 HD domain; Region: HD_4; pfam13328 290338011686 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290338011687 synthetase active site [active] 290338011688 NTP binding site [chemical binding]; other site 290338011689 metal binding site [ion binding]; metal-binding site 290338011690 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290338011691 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290338011692 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 290338011693 TRAM domain; Region: TRAM; pfam01938 290338011694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338011695 S-adenosylmethionine binding site [chemical binding]; other site 290338011696 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 290338011697 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 290338011698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338011699 dimerization interface [polypeptide binding]; other site 290338011700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338011701 dimer interface [polypeptide binding]; other site 290338011702 phosphorylation site [posttranslational modification] 290338011703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338011704 ATP binding site [chemical binding]; other site 290338011705 Mg2+ binding site [ion binding]; other site 290338011706 G-X-G motif; other site 290338011707 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 290338011708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338011709 active site 290338011710 phosphorylation site [posttranslational modification] 290338011711 intermolecular recognition site; other site 290338011712 dimerization interface [polypeptide binding]; other site 290338011713 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290338011714 putative binding surface; other site 290338011715 active site 290338011716 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 290338011717 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 290338011718 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 290338011719 active site 290338011720 tetramer interface [polypeptide binding]; other site 290338011721 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 290338011722 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 290338011723 active site 290338011724 tetramer interface [polypeptide binding]; other site 290338011725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011726 D-galactonate transporter; Region: 2A0114; TIGR00893 290338011727 putative substrate translocation pore; other site 290338011728 flavodoxin; Provisional; Region: PRK08105 290338011729 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290338011730 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 290338011731 probable active site [active] 290338011732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 290338011733 SecY interacting protein Syd; Provisional; Region: PRK04968 290338011734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 290338011735 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 290338011736 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 290338011737 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 290338011738 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 290338011739 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290338011740 serine transporter; Region: stp; TIGR00814 290338011741 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290338011742 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290338011743 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290338011744 flap endonuclease-like protein; Provisional; Region: PRK09482 290338011745 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290338011746 active site 290338011747 metal binding site 1 [ion binding]; metal-binding site 290338011748 putative 5' ssDNA interaction site; other site 290338011749 metal binding site 3; metal-binding site 290338011750 metal binding site 2 [ion binding]; metal-binding site 290338011751 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290338011752 putative DNA binding site [nucleotide binding]; other site 290338011753 putative metal binding site [ion binding]; other site 290338011754 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 290338011755 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 290338011756 dimer interface [polypeptide binding]; other site 290338011757 active site 290338011758 metal binding site [ion binding]; metal-binding site 290338011759 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 290338011760 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290338011761 intersubunit interface [polypeptide binding]; other site 290338011762 active site 290338011763 Zn2+ binding site [ion binding]; other site 290338011764 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 290338011765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011766 putative substrate translocation pore; other site 290338011767 L-fucose isomerase; Provisional; Region: fucI; PRK10991 290338011768 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 290338011769 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290338011770 trimer interface [polypeptide binding]; other site 290338011771 substrate binding site [chemical binding]; other site 290338011772 Mn binding site [ion binding]; other site 290338011773 L-fuculokinase; Provisional; Region: PRK10331 290338011774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290338011775 nucleotide binding site [chemical binding]; other site 290338011776 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 290338011777 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 290338011778 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290338011779 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338011780 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 290338011781 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 290338011782 hypothetical protein; Provisional; Region: PRK10873 290338011783 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 290338011784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338011785 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 290338011786 dimerization interface [polypeptide binding]; other site 290338011787 substrate binding pocket [chemical binding]; other site 290338011788 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 290338011789 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290338011790 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290338011791 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338011792 catalytic residue [active] 290338011793 CsdA-binding activator; Provisional; Region: PRK15019 290338011794 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 290338011795 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 290338011796 putative ATP binding site [chemical binding]; other site 290338011797 putative substrate interface [chemical binding]; other site 290338011798 murein transglycosylase A; Provisional; Region: mltA; PRK11162 290338011799 MltA specific insert domain; Region: MltA; pfam03562 290338011800 3D domain; Region: 3D; pfam06725 290338011801 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 290338011802 AMIN domain; Region: AMIN; pfam11741 290338011803 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290338011804 active site 290338011805 metal binding site [ion binding]; metal-binding site 290338011806 N-acetylglutamate synthase; Validated; Region: PRK05279 290338011807 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 290338011808 putative nucleotide binding site [chemical binding]; other site 290338011809 putative substrate binding site [chemical binding]; other site 290338011810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338011811 Coenzyme A binding pocket [chemical binding]; other site 290338011812 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 290338011813 AAA domain; Region: AAA_30; pfam13604 290338011814 Family description; Region: UvrD_C_2; pfam13538 290338011815 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 290338011816 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 290338011817 protease3; Provisional; Region: PRK15101 290338011818 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290338011819 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290338011820 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290338011821 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 290338011822 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 290338011823 hypothetical protein; Provisional; Region: PRK10332 290338011824 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 290338011825 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 290338011826 hypothetical protein; Provisional; Region: PRK11521 290338011827 hypothetical protein; Provisional; Region: PRK10557 290338011828 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 290338011829 hypothetical protein; Provisional; Region: PRK10506 290338011830 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 290338011831 thymidylate synthase; Reviewed; Region: thyA; PRK01827 290338011832 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 290338011833 dimerization interface [polypeptide binding]; other site 290338011834 active site 290338011835 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290338011836 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 290338011837 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290338011838 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290338011839 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290338011840 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290338011841 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 290338011842 putative active site [active] 290338011843 Ap4A binding site [chemical binding]; other site 290338011844 nudix motif; other site 290338011845 putative metal binding site [ion binding]; other site 290338011846 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 290338011847 putative DNA-binding cleft [nucleotide binding]; other site 290338011848 putative DNA clevage site; other site 290338011849 molecular lever; other site 290338011850 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290338011851 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 290338011852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338011853 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338011854 active site 290338011855 catalytic tetrad [active] 290338011856 lysophospholipid transporter LplT; Provisional; Region: PRK11195 290338011857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338011858 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 290338011859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290338011860 putative acyl-acceptor binding pocket; other site 290338011861 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 290338011862 acyl-activating enzyme (AAE) consensus motif; other site 290338011863 putative AMP binding site [chemical binding]; other site 290338011864 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 290338011865 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338011866 DNA binding site [nucleotide binding] 290338011867 domain linker motif; other site 290338011868 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290338011869 dimerization interface (closed form) [polypeptide binding]; other site 290338011870 ligand binding site [chemical binding]; other site 290338011871 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338011872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338011873 DNA binding site [nucleotide binding] 290338011874 domain linker motif; other site 290338011875 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 290338011876 dimerization interface (closed form) [polypeptide binding]; other site 290338011877 ligand binding site [chemical binding]; other site 290338011878 diaminopimelate decarboxylase; Provisional; Region: PRK11165 290338011879 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290338011880 active site 290338011881 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290338011882 substrate binding site [chemical binding]; other site 290338011883 catalytic residues [active] 290338011884 dimer interface [polypeptide binding]; other site 290338011885 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 290338011886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338011887 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 290338011888 putative dimerization interface [polypeptide binding]; other site 290338011889 putative racemase; Provisional; Region: PRK10200 290338011890 aspartate racemase; Region: asp_race; TIGR00035 290338011891 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 290338011892 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 290338011893 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290338011894 NADP binding site [chemical binding]; other site 290338011895 homodimer interface [polypeptide binding]; other site 290338011896 active site 290338011897 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 290338011898 putative acyltransferase; Provisional; Region: PRK05790 290338011899 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290338011900 dimer interface [polypeptide binding]; other site 290338011901 active site 290338011902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338011903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338011904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290338011905 dimerization interface [polypeptide binding]; other site 290338011906 Predicted membrane protein [Function unknown]; Region: COG4125 290338011907 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 290338011908 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 290338011909 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290338011910 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 290338011911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 290338011912 DNA binding site [nucleotide binding] 290338011913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 290338011914 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 290338011915 putative metal binding site [ion binding]; other site 290338011916 putative homodimer interface [polypeptide binding]; other site 290338011917 putative homotetramer interface [polypeptide binding]; other site 290338011918 putative homodimer-homodimer interface [polypeptide binding]; other site 290338011919 putative allosteric switch controlling residues; other site 290338011920 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 290338011921 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338011922 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 290338011923 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338011924 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338011925 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 290338011926 PapC N-terminal domain; Region: PapC_N; pfam13954 290338011927 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338011928 PapC C-terminal domain; Region: PapC_C; pfam13953 290338011929 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 290338011930 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338011931 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338011932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338011933 Coenzyme A binding pocket [chemical binding]; other site 290338011934 Uncharacterized conserved protein [Function unknown]; Region: COG3592 290338011935 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 290338011936 L-lactate permease; Region: Lactate_perm; cl00701 290338011937 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290338011938 Cysteine-rich domain; Region: CCG; pfam02754 290338011939 Cysteine-rich domain; Region: CCG; pfam02754 290338011940 iron-sulfur cluster-binding protein; Region: TIGR00273 290338011941 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 290338011942 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338011943 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 290338011944 Uncharacterized conserved protein [Function unknown]; Region: COG1556 290338011945 Peptidase family M23; Region: Peptidase_M23; pfam01551 290338011946 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 290338011947 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 290338011948 active site 290338011949 metal binding site [ion binding]; metal-binding site 290338011950 nudix motif; other site 290338011951 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 290338011952 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290338011953 dimer interface [polypeptide binding]; other site 290338011954 putative anticodon binding site; other site 290338011955 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 290338011956 motif 1; other site 290338011957 active site 290338011958 motif 2; other site 290338011959 motif 3; other site 290338011960 peptide chain release factor 2; Provisional; Region: PRK08787 290338011961 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290338011962 RF-1 domain; Region: RF-1; pfam00472 290338011963 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 290338011964 DHH family; Region: DHH; pfam01368 290338011965 DHHA1 domain; Region: DHHA1; pfam02272 290338011966 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 290338011967 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 290338011968 dimerization domain [polypeptide binding]; other site 290338011969 dimer interface [polypeptide binding]; other site 290338011970 catalytic residues [active] 290338011971 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 290338011972 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290338011973 active site 290338011974 Int/Topo IB signature motif; other site 290338011975 flavodoxin FldB; Provisional; Region: PRK12359 290338011976 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 290338011977 hypothetical protein; Provisional; Region: PRK10878 290338011978 putative global regulator; Reviewed; Region: PRK09559 290338011979 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 290338011980 hemolysin; Provisional; Region: PRK15087 290338011981 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 290338011982 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 290338011983 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290338011984 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290338011985 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290338011986 putative active site [active] 290338011987 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 290338011988 beta-galactosidase; Region: BGL; TIGR03356 290338011989 glycine dehydrogenase; Provisional; Region: PRK05367 290338011990 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290338011991 tetramer interface [polypeptide binding]; other site 290338011992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338011993 catalytic residue [active] 290338011994 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290338011995 tetramer interface [polypeptide binding]; other site 290338011996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338011997 catalytic residue [active] 290338011998 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290338011999 lipoyl attachment site [posttranslational modification]; other site 290338012000 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290338012001 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290338012002 oxidoreductase; Provisional; Region: PRK08013 290338012003 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 290338012004 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 290338012005 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 290338012006 proline aminopeptidase P II; Provisional; Region: PRK10879 290338012007 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 290338012008 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290338012009 active site 290338012010 hypothetical protein; Reviewed; Region: PRK01736 290338012011 Z-ring-associated protein; Provisional; Region: PRK10972 290338012012 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 290338012013 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 290338012014 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 290338012015 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 290338012016 ligand binding site [chemical binding]; other site 290338012017 NAD binding site [chemical binding]; other site 290338012018 tetramer interface [polypeptide binding]; other site 290338012019 catalytic site [active] 290338012020 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 290338012021 L-serine binding site [chemical binding]; other site 290338012022 ACT domain interface; other site 290338012023 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 290338012024 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290338012025 active site 290338012026 dimer interface [polypeptide binding]; other site 290338012027 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 290338012028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338012029 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 290338012030 putative dimerization interface [polypeptide binding]; other site 290338012031 Uncharacterized conserved protein [Function unknown]; Region: COG2968 290338012032 oxidative stress defense protein; Provisional; Region: PRK11087 290338012033 arginine exporter protein; Provisional; Region: PRK09304 290338012034 mechanosensitive channel MscS; Provisional; Region: PRK10334 290338012035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290338012036 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 290338012037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338012038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338012039 dimerization interface [polypeptide binding]; other site 290338012040 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 290338012041 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 290338012042 membrane protein FdrA; Validated; Region: PRK06091 290338012043 CoA binding domain; Region: CoA_binding; pfam02629 290338012044 CoA-ligase; Region: Ligase_CoA; pfam00549 290338012045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338012046 D-galactonate transporter; Region: 2A0114; TIGR00893 290338012047 putative substrate translocation pore; other site 290338012048 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 290338012049 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 290338012050 putative substrate binding site [chemical binding]; other site 290338012051 nucleotide binding site [chemical binding]; other site 290338012052 nucleotide binding site [chemical binding]; other site 290338012053 homodimer interface [polypeptide binding]; other site 290338012054 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290338012055 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 290338012056 active site 290338012057 intersubunit interface [polypeptide binding]; other site 290338012058 zinc binding site [ion binding]; other site 290338012059 Na+ binding site [ion binding]; other site 290338012060 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 290338012061 Phosphoglycerate kinase; Region: PGK; pfam00162 290338012062 substrate binding site [chemical binding]; other site 290338012063 hinge regions; other site 290338012064 ADP binding site [chemical binding]; other site 290338012065 catalytic site [active] 290338012066 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 290338012067 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290338012068 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290338012069 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 290338012070 trimer interface [polypeptide binding]; other site 290338012071 putative Zn binding site [ion binding]; other site 290338012072 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 290338012073 hypothetical protein; Provisional; Region: PRK09609 290338012074 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 290338012075 AAA domain; Region: AAA_23; pfam13476 290338012076 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290338012077 Walker A/P-loop; other site 290338012078 ATP binding site [chemical binding]; other site 290338012079 ABC transporter; Region: ABC_tran; pfam00005 290338012080 Q-loop/lid; other site 290338012081 ABC transporter signature motif; other site 290338012082 Walker B; other site 290338012083 D-loop; other site 290338012084 H-loop/switch region; other site 290338012085 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290338012086 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290338012087 Walker A/P-loop; other site 290338012088 ATP binding site [chemical binding]; other site 290338012089 Q-loop/lid; other site 290338012090 ABC transporter signature motif; other site 290338012091 Walker B; other site 290338012092 D-loop; other site 290338012093 H-loop/switch region; other site 290338012094 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 290338012095 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 290338012096 active site 290338012097 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 290338012098 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 290338012099 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 290338012100 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 290338012101 putative active site [active] 290338012102 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 290338012103 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290338012104 putative NAD(P) binding site [chemical binding]; other site 290338012105 catalytic Zn binding site [ion binding]; other site 290338012106 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 290338012107 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 290338012108 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 290338012109 active site 290338012110 P-loop; other site 290338012111 phosphorylation site [posttranslational modification] 290338012112 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338012113 active site 290338012114 phosphorylation site [posttranslational modification] 290338012115 transketolase; Reviewed; Region: PRK12753 290338012116 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290338012117 TPP-binding site [chemical binding]; other site 290338012118 dimer interface [polypeptide binding]; other site 290338012119 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290338012120 PYR/PP interface [polypeptide binding]; other site 290338012121 dimer interface [polypeptide binding]; other site 290338012122 TPP binding site [chemical binding]; other site 290338012123 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290338012124 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 290338012125 outer membrane porin, OprD family; Region: OprD; pfam03573 290338012126 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 290338012127 agmatinase; Region: agmatinase; TIGR01230 290338012128 oligomer interface [polypeptide binding]; other site 290338012129 putative active site [active] 290338012130 Mn binding site [ion binding]; other site 290338012131 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 290338012132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 290338012133 dimer interface [polypeptide binding]; other site 290338012134 active site 290338012135 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290338012136 catalytic residues [active] 290338012137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 290338012138 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290338012139 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290338012140 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290338012141 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290338012142 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 290338012143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338012144 putative substrate translocation pore; other site 290338012145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338012146 hypothetical protein; Provisional; Region: PRK04860 290338012147 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 290338012148 DNA-specific endonuclease I; Provisional; Region: PRK15137 290338012149 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 290338012150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 290338012151 RNA methyltransferase, RsmE family; Region: TIGR00046 290338012152 glutathione synthetase; Provisional; Region: PRK05246 290338012153 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 290338012154 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 290338012155 hypothetical protein; Validated; Region: PRK00228 290338012156 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 290338012157 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 290338012158 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 290338012159 Walker A motif; other site 290338012160 ATP binding site [chemical binding]; other site 290338012161 Walker B motif; other site 290338012162 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 290338012163 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290338012164 catalytic residue [active] 290338012165 YGGT family; Region: YGGT; pfam02325 290338012166 Predicted integral membrane protein [Function unknown]; Region: COG0762 290338012167 hypothetical protein; Validated; Region: PRK05090 290338012168 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290338012169 active site 290338012170 dimerization interface [polypeptide binding]; other site 290338012171 HemN family oxidoreductase; Provisional; Region: PRK05660 290338012172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290338012173 FeS/SAM binding site; other site 290338012174 HemN C-terminal domain; Region: HemN_C; pfam06969 290338012175 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 290338012176 active site 290338012177 homodimer interface [polypeptide binding]; other site 290338012178 hypothetical protein; Provisional; Region: PRK10626 290338012179 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 290338012180 hypothetical protein; Provisional; Region: PRK11702 290338012181 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 290338012182 adenine DNA glycosylase; Provisional; Region: PRK10880 290338012183 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290338012184 minor groove reading motif; other site 290338012185 helix-hairpin-helix signature motif; other site 290338012186 substrate binding pocket [chemical binding]; other site 290338012187 active site 290338012188 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 290338012189 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 290338012190 DNA binding and oxoG recognition site [nucleotide binding] 290338012191 oxidative damage protection protein; Provisional; Region: PRK05408 290338012192 murein transglycosylase C; Provisional; Region: mltC; PRK11671 290338012193 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 290338012194 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290338012195 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290338012196 catalytic residue [active] 290338012197 nucleoside transporter; Region: 2A0110; TIGR00889 290338012198 ornithine decarboxylase; Provisional; Region: PRK13578 290338012199 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 290338012200 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 290338012201 homodimer interface [polypeptide binding]; other site 290338012202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338012203 catalytic residue [active] 290338012204 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 290338012205 Protein of unknown function (DUF554); Region: DUF554; pfam04474 290338012206 Transposase; Region: HTH_Tnp_1; pfam01527 290338012207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290338012208 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 290338012209 ParB-like nuclease domain; Region: ParBc; cl02129 290338012210 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 290338012211 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 290338012212 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 290338012213 Protein of unknown function (DUF796); Region: DUF796; cl01226 290338012214 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 290338012215 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 290338012216 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 290338012217 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 290338012218 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 290338012219 PapC N-terminal domain; Region: PapC_N; pfam13954 290338012220 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338012221 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 290338012222 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338012223 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338012224 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338012225 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 290338012226 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 290338012227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338012228 active site 290338012229 phosphorylation site [posttranslational modification] 290338012230 intermolecular recognition site; other site 290338012231 dimerization interface [polypeptide binding]; other site 290338012232 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338012233 DNA binding residues [nucleotide binding] 290338012234 dimerization interface [polypeptide binding]; other site 290338012235 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 290338012236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338012237 substrate binding pocket [chemical binding]; other site 290338012238 membrane-bound complex binding site; other site 290338012239 hinge residues; other site 290338012240 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290338012241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338012242 substrate binding pocket [chemical binding]; other site 290338012243 membrane-bound complex binding site; other site 290338012244 hinge residues; other site 290338012245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338012246 dimer interface [polypeptide binding]; other site 290338012247 phosphorylation site [posttranslational modification] 290338012248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338012249 ATP binding site [chemical binding]; other site 290338012250 Mg2+ binding site [ion binding]; other site 290338012251 G-X-G motif; other site 290338012252 Response regulator receiver domain; Region: Response_reg; pfam00072 290338012253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338012254 active site 290338012255 phosphorylation site [posttranslational modification] 290338012256 intermolecular recognition site; other site 290338012257 dimerization interface [polypeptide binding]; other site 290338012258 Hpt domain; Region: Hpt; pfam01627 290338012259 putative binding surface; other site 290338012260 active site 290338012261 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338012262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290338012263 DNA binding residues [nucleotide binding] 290338012264 dimerization interface [polypeptide binding]; other site 290338012265 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338012266 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338012267 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338012268 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338012269 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338012270 PapC N-terminal domain; Region: PapC_N; pfam13954 290338012271 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338012272 PapC C-terminal domain; Region: PapC_C; pfam13953 290338012273 Fimbrial protein; Region: Fimbrial; pfam00419 290338012274 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290338012275 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 290338012276 DNA binding residues [nucleotide binding] 290338012277 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290338012278 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290338012279 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 290338012280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338012281 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338012282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338012283 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290338012284 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290338012285 putative NAD(P) binding site [chemical binding]; other site 290338012286 putative substrate binding site [chemical binding]; other site 290338012287 catalytic Zn binding site [ion binding]; other site 290338012288 structural Zn binding site [ion binding]; other site 290338012289 dimer interface [polypeptide binding]; other site 290338012290 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 290338012291 CHAP domain; Region: CHAP; pfam05257 290338012292 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 290338012293 putative oxidoreductase; Provisional; Region: PRK09939 290338012294 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290338012295 putative molybdopterin cofactor binding site [chemical binding]; other site 290338012296 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290338012297 putative molybdopterin cofactor binding site; other site 290338012298 putative S-transferase; Provisional; Region: PRK11752 290338012299 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 290338012300 C-terminal domain interface [polypeptide binding]; other site 290338012301 GSH binding site (G-site) [chemical binding]; other site 290338012302 dimer interface [polypeptide binding]; other site 290338012303 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 290338012304 dimer interface [polypeptide binding]; other site 290338012305 N-terminal domain interface [polypeptide binding]; other site 290338012306 active site 290338012307 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290338012308 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 290338012309 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 290338012310 putative ligand binding residues [chemical binding]; other site 290338012311 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290338012312 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 290338012313 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 290338012314 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 290338012315 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 290338012316 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 290338012317 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 290338012318 putative substrate-binding site; other site 290338012319 nickel binding site [ion binding]; other site 290338012320 hydrogenase 2 large subunit; Provisional; Region: PRK10467 290338012321 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 290338012322 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 290338012323 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 290338012324 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 290338012325 4Fe-4S binding domain; Region: Fer4_6; pfam12837 290338012326 hydrogenase 2 small subunit; Provisional; Region: PRK10468 290338012327 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 290338012328 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 290338012329 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 290338012330 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 290338012331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338012332 dimer interface [polypeptide binding]; other site 290338012333 putative CheW interface [polypeptide binding]; other site 290338012334 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290338012335 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290338012336 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338012337 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338012338 active site 290338012339 catalytic tetrad [active] 290338012340 biopolymer transport protein ExbD; Provisional; Region: PRK11267 290338012341 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 290338012342 biopolymer transport protein ExbB; Provisional; Region: PRK10414 290338012343 cystathionine beta-lyase; Provisional; Region: PRK08114 290338012344 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290338012345 homodimer interface [polypeptide binding]; other site 290338012346 substrate-cofactor binding pocket; other site 290338012347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338012348 catalytic residue [active] 290338012349 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290338012350 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290338012351 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 290338012352 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290338012353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338012354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338012355 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 290338012356 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 290338012357 dimer interface [polypeptide binding]; other site 290338012358 active site 290338012359 metal binding site [ion binding]; metal-binding site 290338012360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290338012361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290338012362 active site 290338012363 catalytic tetrad [active] 290338012364 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 290338012365 nucleotide binding site/active site [active] 290338012366 hypothetical protein; Provisional; Region: PRK01254 290338012367 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 290338012368 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 290338012369 FtsI repressor; Provisional; Region: PRK10883 290338012370 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290338012371 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290338012372 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 290338012373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290338012374 putative acyl-acceptor binding pocket; other site 290338012375 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 290338012376 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290338012377 CAP-like domain; other site 290338012378 active site 290338012379 primary dimer interface [polypeptide binding]; other site 290338012380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290338012381 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 290338012382 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 290338012383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338012384 active site 290338012385 phosphorylation site [posttranslational modification] 290338012386 intermolecular recognition site; other site 290338012387 dimerization interface [polypeptide binding]; other site 290338012388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338012389 DNA binding site [nucleotide binding] 290338012390 sensor protein QseC; Provisional; Region: PRK10337 290338012391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338012392 dimer interface [polypeptide binding]; other site 290338012393 phosphorylation site [posttranslational modification] 290338012394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338012395 ATP binding site [chemical binding]; other site 290338012396 Mg2+ binding site [ion binding]; other site 290338012397 G-X-G motif; other site 290338012398 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 290338012399 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290338012400 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 290338012401 galactoside permease; Reviewed; Region: lacY; PRK09528 290338012402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338012403 putative substrate translocation pore; other site 290338012404 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 290338012405 Cupin domain; Region: Cupin_2; pfam07883 290338012406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338012407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338012408 sequence-specific DNA binding site [nucleotide binding]; other site 290338012409 salt bridge; other site 290338012410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338012411 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 290338012412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338012413 ATP binding site [chemical binding]; other site 290338012414 Mg2+ binding site [ion binding]; other site 290338012415 G-X-G motif; other site 290338012416 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290338012417 anchoring element; other site 290338012418 dimer interface [polypeptide binding]; other site 290338012419 ATP binding site [chemical binding]; other site 290338012420 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290338012421 active site 290338012422 metal binding site [ion binding]; metal-binding site 290338012423 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290338012424 esterase YqiA; Provisional; Region: PRK11071 290338012425 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290338012426 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 290338012427 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290338012428 active site 290338012429 metal binding site [ion binding]; metal-binding site 290338012430 hexamer interface [polypeptide binding]; other site 290338012431 putative dehydrogenase; Provisional; Region: PRK11039 290338012432 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 290338012433 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290338012434 dimer interface [polypeptide binding]; other site 290338012435 ADP-ribose binding site [chemical binding]; other site 290338012436 active site 290338012437 nudix motif; other site 290338012438 metal binding site [ion binding]; metal-binding site 290338012439 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 290338012440 hypothetical protein; Provisional; Region: PRK11653 290338012441 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 290338012442 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 290338012443 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 290338012444 putative active site [active] 290338012445 metal binding site [ion binding]; metal-binding site 290338012446 zinc transporter ZupT; Provisional; Region: PRK04201 290338012447 ZIP Zinc transporter; Region: Zip; pfam02535 290338012448 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 290338012449 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 290338012450 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 290338012451 FMN riboswitch (RFN element) 290338012452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 290338012453 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 290338012454 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 290338012455 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 290338012456 putative ribose interaction site [chemical binding]; other site 290338012457 putative ADP binding site [chemical binding]; other site 290338012458 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290338012459 active site 290338012460 nucleotide binding site [chemical binding]; other site 290338012461 HIGH motif; other site 290338012462 KMSKS motif; other site 290338012463 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 290338012464 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290338012465 metal binding triad; other site 290338012466 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290338012467 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290338012468 metal binding triad; other site 290338012469 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290338012470 Uncharacterized conserved protein [Function unknown]; Region: COG3025 290338012471 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 290338012472 putative active site [active] 290338012473 putative metal binding residues [ion binding]; other site 290338012474 signature motif; other site 290338012475 putative triphosphate binding site [ion binding]; other site 290338012476 CHAD domain; Region: CHAD; pfam05235 290338012477 SH3 domain-containing protein; Provisional; Region: PRK10884 290338012478 Bacterial SH3 domain homologues; Region: SH3b; smart00287 290338012479 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 290338012480 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290338012481 active site 290338012482 NTP binding site [chemical binding]; other site 290338012483 metal binding triad [ion binding]; metal-binding site 290338012484 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290338012485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290338012486 Zn2+ binding site [ion binding]; other site 290338012487 Mg2+ binding site [ion binding]; other site 290338012488 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 290338012489 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 290338012490 homooctamer interface [polypeptide binding]; other site 290338012491 active site 290338012492 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 290338012493 transcriptional activator TtdR; Provisional; Region: PRK09801 290338012494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338012495 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 290338012496 putative effector binding pocket; other site 290338012497 putative dimerization interface [polypeptide binding]; other site 290338012498 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 290338012499 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 290338012500 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 290338012501 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290338012502 transmembrane helices; other site 290338012503 UreD urease accessory protein; Region: UreD; cl00530 290338012504 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 290338012505 alpha-gamma subunit interface [polypeptide binding]; other site 290338012506 beta-gamma subunit interface [polypeptide binding]; other site 290338012507 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 290338012508 gamma-beta subunit interface [polypeptide binding]; other site 290338012509 alpha-beta subunit interface [polypeptide binding]; other site 290338012510 urease subunit alpha; Reviewed; Region: ureC; PRK13207 290338012511 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 290338012512 subunit interactions [polypeptide binding]; other site 290338012513 active site 290338012514 flap region; other site 290338012515 UreE urease accessory protein, C-terminal domain; Region: UreE_C; pfam05194 290338012516 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 290338012517 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 290338012518 UreF; Region: UreF; pfam01730 290338012519 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338012520 UGMP family protein; Validated; Region: PRK09604 290338012521 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 290338012522 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 290338012523 DNA primase; Validated; Region: dnaG; PRK05667 290338012524 CHC2 zinc finger; Region: zf-CHC2; pfam01807 290338012525 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290338012526 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290338012527 active site 290338012528 metal binding site [ion binding]; metal-binding site 290338012529 interdomain interaction site; other site 290338012530 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290338012531 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 290338012532 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 290338012533 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 290338012534 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290338012535 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 290338012536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338012537 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290338012538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290338012539 DNA binding residues [nucleotide binding] 290338012540 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 290338012541 active site 290338012542 SUMO-1 interface [polypeptide binding]; other site 290338012543 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 290338012544 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 290338012545 PAS domain; Region: PAS; smart00091 290338012546 putative active site [active] 290338012547 heme pocket [chemical binding]; other site 290338012548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338012549 Walker A motif; other site 290338012550 ATP binding site [chemical binding]; other site 290338012551 Walker B motif; other site 290338012552 arginine finger; other site 290338012553 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290338012554 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 290338012555 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 290338012556 dimer interface [polypeptide binding]; other site 290338012557 active site 290338012558 metal binding site [ion binding]; metal-binding site 290338012559 chaperone protein dnaJ-related; Provisional; Region: PLN03165 290338012560 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 290338012561 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290338012562 DAK2 domain; Region: Dak2; pfam02734 290338012563 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290338012564 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290338012565 FAD binding pocket [chemical binding]; other site 290338012566 FAD binding motif [chemical binding]; other site 290338012567 phosphate binding motif [ion binding]; other site 290338012568 NAD binding pocket [chemical binding]; other site 290338012569 Predicted transcriptional regulators [Transcription]; Region: COG1695 290338012570 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290338012571 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 290338012572 CHASE3 domain; Region: CHASE3; cl05000 290338012573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338012574 dimerization interface [polypeptide binding]; other site 290338012575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338012576 dimer interface [polypeptide binding]; other site 290338012577 putative CheW interface [polypeptide binding]; other site 290338012578 PAS fold; Region: PAS_3; pfam08447 290338012579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338012580 putative active site [active] 290338012581 heme pocket [chemical binding]; other site 290338012582 HAMP domain; Region: HAMP; pfam00672 290338012583 dimerization interface [polypeptide binding]; other site 290338012584 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 290338012585 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 290338012586 dimer interface [polypeptide binding]; other site 290338012587 putative CheW interface [polypeptide binding]; other site 290338012588 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 290338012589 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338012590 inhibitor-cofactor binding pocket; inhibition site 290338012591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338012592 catalytic residue [active] 290338012593 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290338012594 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 290338012595 active site 290338012596 FMN binding site [chemical binding]; other site 290338012597 2,4-decadienoyl-CoA binding site; other site 290338012598 catalytic residue [active] 290338012599 4Fe-4S cluster binding site [ion binding]; other site 290338012600 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290338012601 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 290338012602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338012603 S-adenosylmethionine binding site [chemical binding]; other site 290338012604 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 290338012605 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290338012606 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338012607 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290338012608 serine/threonine transporter SstT; Provisional; Region: PRK13628 290338012609 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338012610 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 290338012611 galactarate dehydratase; Region: galactar-dH20; TIGR03248 290338012612 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 290338012613 Glucuronate isomerase; Region: UxaC; pfam02614 290338012614 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 290338012615 D-galactonate transporter; Region: 2A0114; TIGR00893 290338012616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338012617 putative substrate translocation pore; other site 290338012618 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 290338012619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338012620 DNA-binding site [nucleotide binding]; DNA binding site 290338012621 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290338012622 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290338012623 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290338012624 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 290338012625 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 290338012626 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 290338012627 Predicted membrane protein [Function unknown]; Region: COG5393 290338012628 YqjK-like protein; Region: YqjK; pfam13997 290338012629 Predicted membrane protein [Function unknown]; Region: COG2259 290338012630 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 290338012631 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 290338012632 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 290338012633 putative dimer interface [polypeptide binding]; other site 290338012634 N-terminal domain interface [polypeptide binding]; other site 290338012635 putative substrate binding pocket (H-site) [chemical binding]; other site 290338012636 Predicted membrane protein [Function unknown]; Region: COG3152 290338012637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338012638 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 290338012639 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290338012640 dimerization interface [polypeptide binding]; other site 290338012641 Pirin-related protein [General function prediction only]; Region: COG1741 290338012642 Pirin; Region: Pirin; pfam02678 290338012643 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 290338012644 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290338012645 serine transporter; Region: stp; TIGR00814 290338012646 L-serine dehydratase TdcG; Provisional; Region: PRK15040 290338012647 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290338012648 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290338012649 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 290338012650 homotrimer interaction site [polypeptide binding]; other site 290338012651 putative active site [active] 290338012652 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 290338012653 Pyruvate formate lyase 1; Region: PFL1; cd01678 290338012654 coenzyme A binding site [chemical binding]; other site 290338012655 active site 290338012656 catalytic residues [active] 290338012657 glycine loop; other site 290338012658 propionate/acetate kinase; Provisional; Region: PRK12379 290338012659 Acetokinase family; Region: Acetate_kinase; cl17229 290338012660 threonine/serine transporter TdcC; Provisional; Region: PRK13629 290338012661 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290338012662 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 290338012663 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 290338012664 tetramer interface [polypeptide binding]; other site 290338012665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338012666 catalytic residue [active] 290338012667 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 290338012668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338012669 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 290338012670 putative substrate binding pocket [chemical binding]; other site 290338012671 putative dimerization interface [polypeptide binding]; other site 290338012672 glycerate kinase I; Provisional; Region: PRK10342 290338012673 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 290338012674 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290338012675 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 290338012676 galactarate dehydratase; Region: galactar-dH20; TIGR03248 290338012677 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 290338012678 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 290338012679 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 290338012680 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290338012681 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338012682 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 290338012683 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 290338012684 active site 290338012685 phosphorylation site [posttranslational modification] 290338012686 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 290338012687 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 290338012688 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 290338012689 active pocket/dimerization site; other site 290338012690 active site 290338012691 phosphorylation site [posttranslational modification] 290338012692 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 290338012693 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 290338012694 active site 290338012695 dimer interface [polypeptide binding]; other site 290338012696 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 290338012697 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290338012698 dimer interface [polypeptide binding]; other site 290338012699 active site 290338012700 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 290338012701 putative active site [active] 290338012702 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290338012703 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290338012704 intersubunit interface [polypeptide binding]; other site 290338012705 active site 290338012706 zinc binding site [ion binding]; other site 290338012707 Na+ binding site [ion binding]; other site 290338012708 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 290338012709 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290338012710 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290338012711 active site turn [active] 290338012712 phosphorylation site [posttranslational modification] 290338012713 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 290338012714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338012715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338012716 homodimer interface [polypeptide binding]; other site 290338012717 catalytic residue [active] 290338012718 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 290338012719 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 290338012720 putative SAM binding site [chemical binding]; other site 290338012721 putative homodimer interface [polypeptide binding]; other site 290338012722 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 290338012723 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290338012724 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 290338012725 putative ligand binding site [chemical binding]; other site 290338012726 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 290338012727 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290338012728 dimer interface [polypeptide binding]; other site 290338012729 active site 290338012730 outer membrane lipoprotein; Provisional; Region: PRK11023 290338012731 BON domain; Region: BON; pfam04972 290338012732 BON domain; Region: BON; pfam04972 290338012733 Predicted permease; Region: DUF318; pfam03773 290338012734 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 290338012735 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290338012736 NAD binding site [chemical binding]; other site 290338012737 active site 290338012738 hypothetical protein; Provisional; Region: PRK03467 290338012739 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 290338012740 GIY-YIG motif/motif A; other site 290338012741 putative active site [active] 290338012742 putative metal binding site [ion binding]; other site 290338012743 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290338012744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338012745 Coenzyme A binding pocket [chemical binding]; other site 290338012746 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 290338012747 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290338012748 Peptidase family U32; Region: Peptidase_U32; pfam01136 290338012749 putative protease; Provisional; Region: PRK15447 290338012750 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290338012751 hypothetical protein; Provisional; Region: PRK10508 290338012752 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290338012753 tryptophan permease; Provisional; Region: PRK10483 290338012754 aromatic amino acid transport protein; Region: araaP; TIGR00837 290338012755 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 290338012756 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290338012757 ATP binding site [chemical binding]; other site 290338012758 Mg++ binding site [ion binding]; other site 290338012759 motif III; other site 290338012760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338012761 nucleotide binding region [chemical binding]; other site 290338012762 ATP-binding site [chemical binding]; other site 290338012763 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 290338012764 putative RNA binding site [nucleotide binding]; other site 290338012765 lipoprotein NlpI; Provisional; Region: PRK11189 290338012766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338012767 binding surface 290338012768 TPR motif; other site 290338012769 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 290338012770 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 290338012771 RNase E interface [polypeptide binding]; other site 290338012772 trimer interface [polypeptide binding]; other site 290338012773 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 290338012774 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290338012775 RNase E interface [polypeptide binding]; other site 290338012776 trimer interface [polypeptide binding]; other site 290338012777 active site 290338012778 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290338012779 putative nucleic acid binding region [nucleotide binding]; other site 290338012780 G-X-X-G motif; other site 290338012781 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290338012782 RNA binding site [nucleotide binding]; other site 290338012783 domain interface; other site 290338012784 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290338012785 16S/18S rRNA binding site [nucleotide binding]; other site 290338012786 S13e-L30e interaction site [polypeptide binding]; other site 290338012787 25S rRNA binding site [nucleotide binding]; other site 290338012788 ribosomal s15 leader 290338012789 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 290338012790 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 290338012791 RNA binding site [nucleotide binding]; other site 290338012792 active site 290338012793 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 290338012794 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 290338012795 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290338012796 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 290338012797 translation initiation factor IF-2; Region: IF-2; TIGR00487 290338012798 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290338012799 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 290338012800 G1 box; other site 290338012801 putative GEF interaction site [polypeptide binding]; other site 290338012802 GTP/Mg2+ binding site [chemical binding]; other site 290338012803 Switch I region; other site 290338012804 G2 box; other site 290338012805 G3 box; other site 290338012806 Switch II region; other site 290338012807 G4 box; other site 290338012808 G5 box; other site 290338012809 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290338012810 Translation-initiation factor 2; Region: IF-2; pfam11987 290338012811 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290338012812 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 290338012813 NusA N-terminal domain; Region: NusA_N; pfam08529 290338012814 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 290338012815 RNA binding site [nucleotide binding]; other site 290338012816 homodimer interface [polypeptide binding]; other site 290338012817 NusA-like KH domain; Region: KH_5; pfam13184 290338012818 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290338012819 G-X-X-G motif; other site 290338012820 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 290338012821 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 290338012822 ribosome maturation protein RimP; Reviewed; Region: PRK00092 290338012823 Sm and related proteins; Region: Sm_like; cl00259 290338012824 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 290338012825 putative oligomer interface [polypeptide binding]; other site 290338012826 putative RNA binding site [nucleotide binding]; other site 290338012827 argininosuccinate synthase; Validated; Region: PRK05370 290338012828 Preprotein translocase SecG subunit; Region: SecG; pfam03840 290338012829 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 290338012830 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 290338012831 active site 290338012832 substrate binding site [chemical binding]; other site 290338012833 metal binding site [ion binding]; metal-binding site 290338012834 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290338012835 dihydropteroate synthase; Region: DHPS; TIGR01496 290338012836 substrate binding pocket [chemical binding]; other site 290338012837 dimer interface [polypeptide binding]; other site 290338012838 inhibitor binding site; inhibition site 290338012839 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 290338012840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338012841 Walker A motif; other site 290338012842 ATP binding site [chemical binding]; other site 290338012843 Walker B motif; other site 290338012844 arginine finger; other site 290338012845 Peptidase family M41; Region: Peptidase_M41; pfam01434 290338012846 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 290338012847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338012848 S-adenosylmethionine binding site [chemical binding]; other site 290338012849 RNA-binding protein YhbY; Provisional; Region: PRK10343 290338012850 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290338012851 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290338012852 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290338012853 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 290338012854 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 290338012855 GTPase CgtA; Reviewed; Region: obgE; PRK12298 290338012856 GTP1/OBG; Region: GTP1_OBG; pfam01018 290338012857 Obg GTPase; Region: Obg; cd01898 290338012858 G1 box; other site 290338012859 GTP/Mg2+ binding site [chemical binding]; other site 290338012860 Switch I region; other site 290338012861 G2 box; other site 290338012862 G3 box; other site 290338012863 Switch II region; other site 290338012864 G4 box; other site 290338012865 G5 box; other site 290338012866 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290338012867 EamA-like transporter family; Region: EamA; pfam00892 290338012868 EamA-like transporter family; Region: EamA; cl17759 290338012869 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 290338012870 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290338012871 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290338012872 substrate binding pocket [chemical binding]; other site 290338012873 chain length determination region; other site 290338012874 substrate-Mg2+ binding site; other site 290338012875 catalytic residues [active] 290338012876 aspartate-rich region 1; other site 290338012877 active site lid residues [active] 290338012878 aspartate-rich region 2; other site 290338012879 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 290338012880 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290338012881 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290338012882 hinge; other site 290338012883 active site 290338012884 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 290338012885 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290338012886 anti sigma factor interaction site; other site 290338012887 regulatory phosphorylation site [posttranslational modification]; other site 290338012888 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 290338012889 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 290338012890 mce related protein; Region: MCE; pfam02470 290338012891 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 290338012892 conserved hypothetical integral membrane protein; Region: TIGR00056 290338012893 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 290338012894 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 290338012895 Walker A/P-loop; other site 290338012896 ATP binding site [chemical binding]; other site 290338012897 Q-loop/lid; other site 290338012898 ABC transporter signature motif; other site 290338012899 Walker B; other site 290338012900 D-loop; other site 290338012901 H-loop/switch region; other site 290338012902 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 290338012903 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290338012904 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290338012905 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 290338012906 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 290338012907 putative active site [active] 290338012908 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 290338012909 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 290338012910 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 290338012911 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 290338012912 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 290338012913 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 290338012914 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 290338012915 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 290338012916 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 290338012917 Walker A/P-loop; other site 290338012918 ATP binding site [chemical binding]; other site 290338012919 Q-loop/lid; other site 290338012920 ABC transporter signature motif; other site 290338012921 Walker B; other site 290338012922 D-loop; other site 290338012923 H-loop/switch region; other site 290338012924 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 290338012925 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 290338012926 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 290338012927 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 290338012928 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290338012929 30S subunit binding site; other site 290338012930 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338012931 active site 290338012932 phosphorylation site [posttranslational modification] 290338012933 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 290338012934 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290338012935 dimerization domain swap beta strand [polypeptide binding]; other site 290338012936 regulatory protein interface [polypeptide binding]; other site 290338012937 active site 290338012938 regulatory phosphorylation site [posttranslational modification]; other site 290338012939 hypothetical protein; Provisional; Region: PRK10345 290338012940 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 290338012941 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 290338012942 Transglycosylase; Region: Transgly; cl17702 290338012943 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 290338012944 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 290338012945 conserved cys residue [active] 290338012946 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 290338012947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290338012948 putative active site [active] 290338012949 heme pocket [chemical binding]; other site 290338012950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338012951 dimer interface [polypeptide binding]; other site 290338012952 phosphorylation site [posttranslational modification] 290338012953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338012954 ATP binding site [chemical binding]; other site 290338012955 Mg2+ binding site [ion binding]; other site 290338012956 G-X-G motif; other site 290338012957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338012958 active site 290338012959 phosphorylation site [posttranslational modification] 290338012960 intermolecular recognition site; other site 290338012961 dimerization interface [polypeptide binding]; other site 290338012962 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290338012963 putative binding surface; other site 290338012964 active site 290338012965 radical SAM protein, TIGR01212 family; Region: TIGR01212 290338012966 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290338012967 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290338012968 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290338012969 active site 290338012970 dimer interface [polypeptide binding]; other site 290338012971 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290338012972 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290338012973 active site 290338012974 FMN binding site [chemical binding]; other site 290338012975 substrate binding site [chemical binding]; other site 290338012976 3Fe-4S cluster binding site [ion binding]; other site 290338012977 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290338012978 domain interface; other site 290338012979 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 290338012980 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290338012981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338012982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338012983 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 290338012984 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290338012985 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 290338012986 N-acetylmannosamine kinase; Provisional; Region: PRK05082 290338012987 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290338012988 nucleotide binding site [chemical binding]; other site 290338012989 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 290338012990 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 290338012991 putative active site cavity [active] 290338012992 putative sialic acid transporter; Provisional; Region: PRK03893 290338012993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338012994 putative substrate translocation pore; other site 290338012995 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 290338012996 N-acetylneuraminate lyase; Provisional; Region: PRK04147 290338012997 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 290338012998 inhibitor site; inhibition site 290338012999 active site 290338013000 dimer interface [polypeptide binding]; other site 290338013001 catalytic residue [active] 290338013002 transcriptional regulator NanR; Provisional; Region: PRK03837 290338013003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338013004 DNA-binding site [nucleotide binding]; DNA binding site 290338013005 FCD domain; Region: FCD; pfam07729 290338013006 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 290338013007 stringent starvation protein A; Provisional; Region: sspA; PRK09481 290338013008 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 290338013009 C-terminal domain interface [polypeptide binding]; other site 290338013010 putative GSH binding site (G-site) [chemical binding]; other site 290338013011 dimer interface [polypeptide binding]; other site 290338013012 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 290338013013 dimer interface [polypeptide binding]; other site 290338013014 N-terminal domain interface [polypeptide binding]; other site 290338013015 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 290338013016 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290338013017 23S rRNA interface [nucleotide binding]; other site 290338013018 L3 interface [polypeptide binding]; other site 290338013019 Predicted ATPase [General function prediction only]; Region: COG1485 290338013020 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 290338013021 hypothetical protein; Provisional; Region: PRK11677 290338013022 serine endoprotease; Provisional; Region: PRK10139 290338013023 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290338013024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290338013025 protein binding site [polypeptide binding]; other site 290338013026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290338013027 serine endoprotease; Provisional; Region: PRK10898 290338013028 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290338013029 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290338013030 malate dehydrogenase; Provisional; Region: PRK05086 290338013031 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 290338013032 NAD binding site [chemical binding]; other site 290338013033 dimerization interface [polypeptide binding]; other site 290338013034 Substrate binding site [chemical binding]; other site 290338013035 arginine repressor; Provisional; Region: PRK05066 290338013036 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290338013037 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290338013038 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 290338013039 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 290338013040 RNAase interaction site [polypeptide binding]; other site 290338013041 succinic semialdehyde dehydrogenase; Region: PLN02278 290338013042 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290338013043 tetramerization interface [polypeptide binding]; other site 290338013044 NAD(P) binding site [chemical binding]; other site 290338013045 catalytic residues [active] 290338013046 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 290338013047 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290338013048 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 290338013049 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338013050 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338013051 efflux system membrane protein; Provisional; Region: PRK11594 290338013052 transcriptional regulator; Provisional; Region: PRK10632 290338013053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338013054 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290338013055 putative effector binding pocket; other site 290338013056 dimerization interface [polypeptide binding]; other site 290338013057 protease TldD; Provisional; Region: tldD; PRK10735 290338013058 hypothetical protein; Provisional; Region: PRK10899 290338013059 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290338013060 ribonuclease G; Provisional; Region: PRK11712 290338013061 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290338013062 homodimer interface [polypeptide binding]; other site 290338013063 oligonucleotide binding site [chemical binding]; other site 290338013064 Maf-like protein; Region: Maf; pfam02545 290338013065 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290338013066 active site 290338013067 dimer interface [polypeptide binding]; other site 290338013068 rod shape-determining protein MreD; Provisional; Region: PRK11060 290338013069 rod shape-determining protein MreC; Region: mreC; TIGR00219 290338013070 rod shape-determining protein MreC; Region: MreC; pfam04085 290338013071 rod shape-determining protein MreB; Provisional; Region: PRK13927 290338013072 MreB and similar proteins; Region: MreB_like; cd10225 290338013073 nucleotide binding site [chemical binding]; other site 290338013074 Mg binding site [ion binding]; other site 290338013075 putative protofilament interaction site [polypeptide binding]; other site 290338013076 RodZ interaction site [polypeptide binding]; other site 290338013077 regulatory protein CsrD; Provisional; Region: PRK11059 290338013078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338013079 metal binding site [ion binding]; metal-binding site 290338013080 active site 290338013081 I-site; other site 290338013082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338013083 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 290338013084 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 290338013085 NADP binding site [chemical binding]; other site 290338013086 dimer interface [polypeptide binding]; other site 290338013087 TMAO/DMSO reductase; Reviewed; Region: PRK05363 290338013088 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 290338013089 Moco binding site; other site 290338013090 metal coordination site [ion binding]; other site 290338013091 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 290338013092 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290338013093 Dehydroquinase class II; Region: DHquinase_II; pfam01220 290338013094 active site 290338013095 trimer interface [polypeptide binding]; other site 290338013096 dimer interface [polypeptide binding]; other site 290338013097 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 290338013098 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290338013099 carboxyltransferase (CT) interaction site; other site 290338013100 biotinylation site [posttranslational modification]; other site 290338013101 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290338013102 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290338013103 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290338013104 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290338013105 hypothetical protein; Provisional; Region: PRK10633 290338013106 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 290338013107 Na binding site [ion binding]; other site 290338013108 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 290338013109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290338013110 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 290338013111 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 290338013112 active site 290338013113 zinc binding site [ion binding]; other site 290338013114 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 290338013115 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290338013116 FMN binding site [chemical binding]; other site 290338013117 active site 290338013118 catalytic residues [active] 290338013119 substrate binding site [chemical binding]; other site 290338013120 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 290338013121 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 290338013122 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290338013123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338013124 DNA methylase; Region: N6_N4_Mtase; pfam01555 290338013125 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 290338013126 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 290338013127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338013128 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 290338013129 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 290338013130 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338013131 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338013132 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 290338013133 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 290338013134 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 290338013135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290338013136 substrate binding pocket [chemical binding]; other site 290338013137 membrane-bound complex binding site; other site 290338013138 hinge residues; other site 290338013139 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 290338013140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290338013141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013142 dimer interface [polypeptide binding]; other site 290338013143 ABC-ATPase subunit interface; other site 290338013144 putative PBP binding loops; other site 290338013145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013146 dimer interface [polypeptide binding]; other site 290338013147 conserved gate region; other site 290338013148 putative PBP binding loops; other site 290338013149 ABC-ATPase subunit interface; other site 290338013150 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290338013151 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290338013152 Walker A/P-loop; other site 290338013153 ATP binding site [chemical binding]; other site 290338013154 Q-loop/lid; other site 290338013155 ABC transporter signature motif; other site 290338013156 Walker B; other site 290338013157 D-loop; other site 290338013158 H-loop/switch region; other site 290338013159 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290338013160 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290338013161 trimer interface [polypeptide binding]; other site 290338013162 putative metal binding site [ion binding]; other site 290338013163 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 290338013164 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290338013165 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290338013166 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290338013167 shikimate binding site; other site 290338013168 NAD(P) binding site [chemical binding]; other site 290338013169 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 290338013170 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290338013171 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 290338013172 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290338013173 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290338013174 hypothetical protein; Validated; Region: PRK03430 290338013175 hypothetical protein; Provisional; Region: PRK10736 290338013176 DNA protecting protein DprA; Region: dprA; TIGR00732 290338013177 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290338013178 active site 290338013179 catalytic residues [active] 290338013180 metal binding site [ion binding]; metal-binding site 290338013181 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290338013182 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290338013183 putative active site [active] 290338013184 putative cosubstrate binding site; other site 290338013185 substrate binding site [chemical binding]; other site 290338013186 catalytic site [active] 290338013187 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290338013188 substrate binding site [chemical binding]; other site 290338013189 16S rRNA methyltransferase B; Provisional; Region: PRK10901 290338013190 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 290338013191 putative RNA binding site [nucleotide binding]; other site 290338013192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338013193 S-adenosylmethionine binding site [chemical binding]; other site 290338013194 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 290338013195 TrkA-N domain; Region: TrkA_N; pfam02254 290338013196 TrkA-C domain; Region: TrkA_C; pfam02080 290338013197 TrkA-N domain; Region: TrkA_N; pfam02254 290338013198 TrkA-C domain; Region: TrkA_C; pfam02080 290338013199 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290338013200 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 290338013201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 290338013202 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 290338013203 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290338013204 DNA binding residues [nucleotide binding] 290338013205 dimer interface [polypeptide binding]; other site 290338013206 metal binding site [ion binding]; metal-binding site 290338013207 hypothetical protein; Provisional; Region: PRK10203 290338013208 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 290338013209 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290338013210 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290338013211 alphaNTD homodimer interface [polypeptide binding]; other site 290338013212 alphaNTD - beta interaction site [polypeptide binding]; other site 290338013213 alphaNTD - beta' interaction site [polypeptide binding]; other site 290338013214 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 290338013215 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290338013216 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290338013217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338013218 RNA binding surface [nucleotide binding]; other site 290338013219 30S ribosomal protein S11; Validated; Region: PRK05309 290338013220 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 290338013221 30S ribosomal protein S13; Region: bact_S13; TIGR03631 290338013222 alpha operon ribosome binding site 290338013223 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290338013224 SecY translocase; Region: SecY; pfam00344 290338013225 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 290338013226 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290338013227 23S rRNA binding site [nucleotide binding]; other site 290338013228 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290338013229 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290338013230 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290338013231 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290338013232 23S rRNA interface [nucleotide binding]; other site 290338013233 5S rRNA interface [nucleotide binding]; other site 290338013234 L27 interface [polypeptide binding]; other site 290338013235 L5 interface [polypeptide binding]; other site 290338013236 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290338013237 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290338013238 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290338013239 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 290338013240 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 290338013241 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290338013242 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290338013243 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290338013244 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 290338013245 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 290338013246 RNA binding site [nucleotide binding]; other site 290338013247 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 290338013248 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 290338013249 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290338013250 23S rRNA interface [nucleotide binding]; other site 290338013251 putative translocon interaction site; other site 290338013252 signal recognition particle (SRP54) interaction site; other site 290338013253 L23 interface [polypeptide binding]; other site 290338013254 trigger factor interaction site; other site 290338013255 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290338013256 23S rRNA interface [nucleotide binding]; other site 290338013257 5S rRNA interface [nucleotide binding]; other site 290338013258 putative antibiotic binding site [chemical binding]; other site 290338013259 L25 interface [polypeptide binding]; other site 290338013260 L27 interface [polypeptide binding]; other site 290338013261 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290338013262 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290338013263 G-X-X-G motif; other site 290338013264 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290338013265 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290338013266 protein-rRNA interface [nucleotide binding]; other site 290338013267 putative translocon binding site; other site 290338013268 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 290338013269 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290338013270 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290338013271 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290338013272 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 290338013273 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 290338013274 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 290338013275 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 290338013276 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 290338013277 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 290338013278 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 290338013279 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 290338013280 heme binding site [chemical binding]; other site 290338013281 ferroxidase pore; other site 290338013282 ferroxidase diiron center [ion binding]; other site 290338013283 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 290338013284 elongation factor Tu; Reviewed; Region: PRK00049 290338013285 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290338013286 G1 box; other site 290338013287 GEF interaction site [polypeptide binding]; other site 290338013288 GTP/Mg2+ binding site [chemical binding]; other site 290338013289 Switch I region; other site 290338013290 G2 box; other site 290338013291 G3 box; other site 290338013292 Switch II region; other site 290338013293 G4 box; other site 290338013294 G5 box; other site 290338013295 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290338013296 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290338013297 Antibiotic Binding Site [chemical binding]; other site 290338013298 elongation factor G; Reviewed; Region: PRK00007 290338013299 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290338013300 G1 box; other site 290338013301 putative GEF interaction site [polypeptide binding]; other site 290338013302 GTP/Mg2+ binding site [chemical binding]; other site 290338013303 Switch I region; other site 290338013304 G2 box; other site 290338013305 G3 box; other site 290338013306 Switch II region; other site 290338013307 G4 box; other site 290338013308 G5 box; other site 290338013309 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290338013310 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290338013311 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290338013312 30S ribosomal protein S7; Validated; Region: PRK05302 290338013313 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290338013314 S17 interaction site [polypeptide binding]; other site 290338013315 S8 interaction site; other site 290338013316 16S rRNA interaction site [nucleotide binding]; other site 290338013317 streptomycin interaction site [chemical binding]; other site 290338013318 23S rRNA interaction site [nucleotide binding]; other site 290338013319 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290338013320 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 290338013321 sulfur relay protein TusC; Validated; Region: PRK00211 290338013322 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 290338013323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 290338013324 YheO-like PAS domain; Region: PAS_6; pfam08348 290338013325 HTH domain; Region: HTH_22; pfam13309 290338013326 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 290338013327 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 290338013328 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290338013329 phi X174 lysis protein; Provisional; Region: PRK02793 290338013330 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 290338013331 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290338013332 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 290338013333 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 290338013334 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 290338013335 TrkA-N domain; Region: TrkA_N; pfam02254 290338013336 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 290338013337 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 290338013338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338013339 Walker A/P-loop; other site 290338013340 ATP binding site [chemical binding]; other site 290338013341 Q-loop/lid; other site 290338013342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338013343 ABC transporter signature motif; other site 290338013344 Walker B; other site 290338013345 D-loop; other site 290338013346 ABC transporter; Region: ABC_tran_2; pfam12848 290338013347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290338013348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338013349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338013350 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 290338013351 putative dimerization interface [polypeptide binding]; other site 290338013352 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290338013353 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 290338013354 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 290338013355 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 290338013356 Membrane transport protein; Region: Mem_trans; cl09117 290338013357 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 290338013358 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 290338013359 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 290338013360 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 290338013361 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 290338013362 Coenzyme A transferase; Region: CoA_trans; cl17247 290338013363 putative hydrolase; Provisional; Region: PRK10985 290338013364 hypothetical protein; Provisional; Region: PRK04966 290338013365 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 290338013366 active site 290338013367 hypothetical protein; Provisional; Region: PRK10738 290338013368 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 290338013369 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290338013370 ligand binding site [chemical binding]; other site 290338013371 flexible hinge region; other site 290338013372 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290338013373 putative switch regulator; other site 290338013374 non-specific DNA interactions [nucleotide binding]; other site 290338013375 DNA binding site [nucleotide binding] 290338013376 sequence specific DNA binding site [nucleotide binding]; other site 290338013377 putative cAMP binding site [chemical binding]; other site 290338013378 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 290338013379 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 290338013380 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290338013381 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 290338013382 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338013383 inhibitor-cofactor binding pocket; inhibition site 290338013384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338013385 catalytic residue [active] 290338013386 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 290338013387 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290338013388 glutamine binding [chemical binding]; other site 290338013389 catalytic triad [active] 290338013390 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 290338013391 cell filamentation protein Fic; Provisional; Region: PRK10347 290338013392 hypothetical protein; Provisional; Region: PRK10204 290338013393 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 290338013394 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 290338013395 substrate binding site [chemical binding]; other site 290338013396 putative transporter; Provisional; Region: PRK03699 290338013397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338013398 putative substrate translocation pore; other site 290338013399 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290338013400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338013401 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290338013402 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290338013403 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290338013404 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290338013405 nitrite transporter NirC; Provisional; Region: PRK11562 290338013406 siroheme synthase; Provisional; Region: cysG; PRK10637 290338013407 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 290338013408 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 290338013409 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290338013410 active site 290338013411 SAM binding site [chemical binding]; other site 290338013412 homodimer interface [polypeptide binding]; other site 290338013413 Autotransporter beta-domain; Region: Autotransporter; pfam03797 290338013414 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 290338013415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290338013416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290338013417 catalytic residue [active] 290338013418 Protein of unknown function; Region: YhfT; pfam10797 290338013419 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 290338013420 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 290338013421 active site 290338013422 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 290338013423 substrate binding pocket [chemical binding]; other site 290338013424 homodimer interaction site [polypeptide binding]; other site 290338013425 putative mutase; Provisional; Region: PRK12383 290338013426 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 290338013427 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 290338013428 dimer interface [polypeptide binding]; other site 290338013429 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 290338013430 active site 290338013431 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290338013432 substrate binding site [chemical binding]; other site 290338013433 catalytic residue [active] 290338013434 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290338013435 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290338013436 active site 290338013437 HIGH motif; other site 290338013438 dimer interface [polypeptide binding]; other site 290338013439 KMSKS motif; other site 290338013440 phosphoglycolate phosphatase; Provisional; Region: PRK13222 290338013441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338013442 motif II; other site 290338013443 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290338013444 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 290338013445 substrate binding site [chemical binding]; other site 290338013446 hexamer interface [polypeptide binding]; other site 290338013447 metal binding site [ion binding]; metal-binding site 290338013448 DNA adenine methylase; Provisional; Region: PRK10904 290338013449 cell division protein DamX; Validated; Region: PRK10905 290338013450 cell division protein DamX; Validated; Region: PRK10905 290338013451 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290338013452 active site 290338013453 dimer interface [polypeptide binding]; other site 290338013454 metal binding site [ion binding]; metal-binding site 290338013455 shikimate kinase; Reviewed; Region: aroK; PRK00131 290338013456 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290338013457 ADP binding site [chemical binding]; other site 290338013458 magnesium binding site [ion binding]; other site 290338013459 putative shikimate binding site; other site 290338013460 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 290338013461 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 290338013462 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 290338013463 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 290338013464 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 290338013465 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 290338013466 Transglycosylase; Region: Transgly; pfam00912 290338013467 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290338013468 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 290338013469 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290338013470 ADP-ribose binding site [chemical binding]; other site 290338013471 dimer interface [polypeptide binding]; other site 290338013472 active site 290338013473 nudix motif; other site 290338013474 metal binding site [ion binding]; metal-binding site 290338013475 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 290338013476 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 290338013477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290338013478 motif II; other site 290338013479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290338013480 RNA binding surface [nucleotide binding]; other site 290338013481 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 290338013482 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 290338013483 dimerization interface [polypeptide binding]; other site 290338013484 domain crossover interface; other site 290338013485 redox-dependent activation switch; other site 290338013486 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 290338013487 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 290338013488 active site 290338013489 substrate-binding site [chemical binding]; other site 290338013490 metal-binding site [ion binding] 290338013491 ATP binding site [chemical binding]; other site 290338013492 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 290338013493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290338013494 dimerization interface [polypeptide binding]; other site 290338013495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290338013496 dimer interface [polypeptide binding]; other site 290338013497 phosphorylation site [posttranslational modification] 290338013498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290338013499 ATP binding site [chemical binding]; other site 290338013500 Mg2+ binding site [ion binding]; other site 290338013501 G-X-G motif; other site 290338013502 osmolarity response regulator; Provisional; Region: ompR; PRK09468 290338013503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290338013504 active site 290338013505 phosphorylation site [posttranslational modification] 290338013506 intermolecular recognition site; other site 290338013507 dimerization interface [polypeptide binding]; other site 290338013508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290338013509 DNA binding site [nucleotide binding] 290338013510 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 290338013511 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290338013512 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290338013513 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 290338013514 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 290338013515 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 290338013516 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 290338013517 RNA binding site [nucleotide binding]; other site 290338013518 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 290338013519 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 290338013520 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 290338013521 G1 box; other site 290338013522 GTP/Mg2+ binding site [chemical binding]; other site 290338013523 Switch I region; other site 290338013524 G2 box; other site 290338013525 G3 box; other site 290338013526 Switch II region; other site 290338013527 G4 box; other site 290338013528 G5 box; other site 290338013529 Nucleoside recognition; Region: Gate; pfam07670 290338013530 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 290338013531 Nucleoside recognition; Region: Gate; pfam07670 290338013532 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 290338013533 carboxylesterase BioH; Provisional; Region: PRK10349 290338013534 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 290338013535 DNA utilization protein GntX; Provisional; Region: PRK11595 290338013536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338013537 active site 290338013538 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 290338013539 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 290338013540 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 290338013541 high-affinity gluconate transporter; Provisional; Region: PRK14984 290338013542 gluconate transporter; Region: gntP; TIGR00791 290338013543 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 290338013544 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 290338013545 maltodextrin phosphorylase; Provisional; Region: PRK14985 290338013546 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 290338013547 active site pocket [active] 290338013548 transcriptional regulator MalT; Provisional; Region: PRK04841 290338013549 AAA ATPase domain; Region: AAA_16; pfam13191 290338013550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290338013551 DNA binding residues [nucleotide binding] 290338013552 dimerization interface [polypeptide binding]; other site 290338013553 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 290338013554 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 290338013555 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290338013556 intramembrane serine protease GlpG; Provisional; Region: PRK10907 290338013557 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 290338013558 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 290338013559 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 290338013560 active site residue [active] 290338013561 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 290338013562 glycogen phosphorylase; Provisional; Region: PRK14986 290338013563 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 290338013564 homodimer interface [polypeptide binding]; other site 290338013565 active site pocket [active] 290338013566 glycogen synthase; Provisional; Region: glgA; PRK00654 290338013567 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 290338013568 ADP-binding pocket [chemical binding]; other site 290338013569 homodimer interface [polypeptide binding]; other site 290338013570 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 290338013571 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 290338013572 ligand binding site; other site 290338013573 oligomer interface; other site 290338013574 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290338013575 dimer interface [polypeptide binding]; other site 290338013576 N-terminal domain interface [polypeptide binding]; other site 290338013577 sulfate 1 binding site; other site 290338013578 glycogen debranching enzyme; Provisional; Region: PRK03705 290338013579 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290338013580 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290338013581 active site 290338013582 catalytic site [active] 290338013583 glycogen branching enzyme; Provisional; Region: PRK05402 290338013584 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 290338013585 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 290338013586 active site 290338013587 catalytic site [active] 290338013588 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 290338013589 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 290338013590 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290338013591 putative antibiotic transporter; Provisional; Region: PRK10739 290338013592 low affinity gluconate transporter; Provisional; Region: PRK10472 290338013593 gluconate transporter; Region: gntP; TIGR00791 290338013594 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290338013595 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 290338013596 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338013597 DNA binding site [nucleotide binding] 290338013598 domain linker motif; other site 290338013599 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 290338013600 putative ligand binding site [chemical binding]; other site 290338013601 putative dimerization interface [polypeptide binding]; other site 290338013602 Pirin-related protein [General function prediction only]; Region: COG1741 290338013603 Pirin; Region: Pirin; pfam02678 290338013604 putative oxidoreductase; Provisional; Region: PRK10206 290338013605 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290338013606 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290338013607 putative acetyltransferase YhhY; Provisional; Region: PRK10140 290338013608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338013609 Coenzyme A binding pocket [chemical binding]; other site 290338013610 Protein of unknown function (DUF796); Region: DUF796; cl01226 290338013611 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 290338013612 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 290338013613 Protein of unknown function (DUF2756); Region: DUF2756; pfam10956 290338013614 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 290338013615 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 290338013616 putative active site [active] 290338013617 catalytic site [active] 290338013618 putative metal binding site [ion binding]; other site 290338013619 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290338013620 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290338013621 Walker A/P-loop; other site 290338013622 ATP binding site [chemical binding]; other site 290338013623 Q-loop/lid; other site 290338013624 ABC transporter signature motif; other site 290338013625 Walker B; other site 290338013626 D-loop; other site 290338013627 H-loop/switch region; other site 290338013628 TOBE domain; Region: TOBE_2; pfam08402 290338013629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290338013630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013631 dimer interface [polypeptide binding]; other site 290338013632 conserved gate region; other site 290338013633 putative PBP binding loops; other site 290338013634 ABC-ATPase subunit interface; other site 290338013635 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290338013636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013637 dimer interface [polypeptide binding]; other site 290338013638 putative PBP binding loops; other site 290338013639 ABC-ATPase subunit interface; other site 290338013640 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 290338013641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290338013642 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 290338013643 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290338013644 Walker A/P-loop; other site 290338013645 ATP binding site [chemical binding]; other site 290338013646 Q-loop/lid; other site 290338013647 ABC transporter signature motif; other site 290338013648 Walker B; other site 290338013649 D-loop; other site 290338013650 H-loop/switch region; other site 290338013651 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 290338013652 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290338013653 Walker A/P-loop; other site 290338013654 ATP binding site [chemical binding]; other site 290338013655 Q-loop/lid; other site 290338013656 ABC transporter signature motif; other site 290338013657 Walker B; other site 290338013658 D-loop; other site 290338013659 H-loop/switch region; other site 290338013660 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 290338013661 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 290338013662 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290338013663 TM-ABC transporter signature motif; other site 290338013664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338013665 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290338013666 TM-ABC transporter signature motif; other site 290338013667 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290338013668 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 290338013669 dimerization interface [polypeptide binding]; other site 290338013670 ligand binding site [chemical binding]; other site 290338013671 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 290338013672 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290338013673 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 290338013674 dimerization interface [polypeptide binding]; other site 290338013675 ligand binding site [chemical binding]; other site 290338013676 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 290338013677 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290338013678 inhibitor-cofactor binding pocket; inhibition site 290338013679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338013680 catalytic residue [active] 290338013681 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 290338013682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290338013683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290338013684 DNA binding residues [nucleotide binding] 290338013685 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 290338013686 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 290338013687 cell division protein FtsE; Provisional; Region: PRK10908 290338013688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338013689 Walker A/P-loop; other site 290338013690 ATP binding site [chemical binding]; other site 290338013691 Q-loop/lid; other site 290338013692 ABC transporter signature motif; other site 290338013693 Walker B; other site 290338013694 D-loop; other site 290338013695 H-loop/switch region; other site 290338013696 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290338013697 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 290338013698 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290338013699 P loop; other site 290338013700 GTP binding site [chemical binding]; other site 290338013701 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 290338013702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338013703 S-adenosylmethionine binding site [chemical binding]; other site 290338013704 hypothetical protein; Provisional; Region: PRK10910 290338013705 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 290338013706 Predicted membrane protein [Function unknown]; Region: COG3714 290338013707 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 290338013708 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290338013709 metal-binding site [ion binding] 290338013710 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290338013711 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 290338013712 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 290338013713 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 290338013714 CPxP motif; other site 290338013715 hypothetical protein; Provisional; Region: PRK11212 290338013716 hypothetical protein; Provisional; Region: PRK11615 290338013717 major facilitator superfamily transporter; Provisional; Region: PRK05122 290338013718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338013719 putative substrate translocation pore; other site 290338013720 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 290338013721 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290338013722 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 290338013723 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290338013724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338013725 S-adenosylmethionine binding site [chemical binding]; other site 290338013726 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 290338013727 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290338013728 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290338013729 putative acyl-acceptor binding pocket; other site 290338013730 Phosphopantetheine attachment site; Region: PP-binding; cl09936 290338013731 acyl carrier protein; Provisional; Region: PRK05350 290338013732 Predicted membrane protein [Function unknown]; Region: COG4648 290338013733 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 290338013734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338013735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290338013736 AMP binding site [chemical binding]; other site 290338013737 active site 290338013738 acyl-activating enzyme (AAE) consensus motif; other site 290338013739 acyl-activating enzyme (AAE) consensus motif; other site 290338013740 CoA binding site [chemical binding]; other site 290338013741 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290338013742 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290338013743 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 290338013744 Ligand binding site; other site 290338013745 Putative Catalytic site; other site 290338013746 DXD motif; other site 290338013747 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290338013748 putative acyl-acceptor binding pocket; other site 290338013749 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290338013750 active site 290338013751 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 290338013752 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 290338013753 Predicted exporter [General function prediction only]; Region: COG4258 290338013754 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 290338013755 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 290338013756 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290338013757 dimer interface [polypeptide binding]; other site 290338013758 active site 290338013759 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 290338013760 putative active site 1 [active] 290338013761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338013762 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 290338013763 NAD(P) binding site [chemical binding]; other site 290338013764 active site 290338013765 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 290338013766 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290338013767 dimer interface [polypeptide binding]; other site 290338013768 active site 290338013769 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 290338013770 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 290338013771 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 290338013772 substrate binding site [chemical binding]; other site 290338013773 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290338013774 nickel transporter permease NikB; Provisional; Region: PRK10352 290338013775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013776 dimer interface [polypeptide binding]; other site 290338013777 conserved gate region; other site 290338013778 putative PBP binding loops; other site 290338013779 ABC-ATPase subunit interface; other site 290338013780 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 290338013781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013782 dimer interface [polypeptide binding]; other site 290338013783 conserved gate region; other site 290338013784 putative PBP binding loops; other site 290338013785 ABC-ATPase subunit interface; other site 290338013786 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 290338013787 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338013788 ATP binding site [chemical binding]; other site 290338013789 Q-loop/lid; other site 290338013790 ABC transporter signature motif; other site 290338013791 Walker B; other site 290338013792 D-loop; other site 290338013793 H-loop/switch region; other site 290338013794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290338013795 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 290338013796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338013797 Walker A/P-loop; other site 290338013798 ATP binding site [chemical binding]; other site 290338013799 Q-loop/lid; other site 290338013800 ABC transporter signature motif; other site 290338013801 Walker B; other site 290338013802 D-loop; other site 290338013803 H-loop/switch region; other site 290338013804 nickel responsive regulator; Provisional; Region: PRK02967 290338013805 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 290338013806 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 290338013807 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290338013808 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 290338013809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290338013810 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290338013811 Walker A/P-loop; other site 290338013812 ATP binding site [chemical binding]; other site 290338013813 Q-loop/lid; other site 290338013814 ABC transporter signature motif; other site 290338013815 Walker B; other site 290338013816 D-loop; other site 290338013817 H-loop/switch region; other site 290338013818 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290338013819 Walker A/P-loop; other site 290338013820 ATP binding site [chemical binding]; other site 290338013821 Q-loop/lid; other site 290338013822 ABC transporter signature motif; other site 290338013823 Walker B; other site 290338013824 D-loop; other site 290338013825 H-loop/switch region; other site 290338013826 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290338013827 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 290338013828 HlyD family secretion protein; Region: HlyD; pfam00529 290338013829 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338013830 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338013831 FOG: CBS domain [General function prediction only]; Region: COG0517 290338013832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290338013833 Divalent cation transporter; Region: MgtE; pfam01769 290338013834 Predicted flavoproteins [General function prediction only]; Region: COG2081 290338013835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338013836 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290338013837 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290338013838 universal stress protein UspB; Provisional; Region: PRK04960 290338013839 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290338013840 Ligand Binding Site [chemical binding]; other site 290338013841 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 290338013842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338013843 putative substrate translocation pore; other site 290338013844 POT family; Region: PTR2; pfam00854 290338013845 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 290338013846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338013847 non-specific DNA binding site [nucleotide binding]; other site 290338013848 salt bridge; other site 290338013849 sequence-specific DNA binding site [nucleotide binding]; other site 290338013850 Predicted transcriptional regulator [Transcription]; Region: COG1959 290338013851 Transcriptional regulator; Region: Rrf2; pfam02082 290338013852 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290338013853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338013854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338013855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290338013856 S-adenosylmethionine binding site [chemical binding]; other site 290338013857 oligopeptidase A; Provisional; Region: PRK10911 290338013858 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 290338013859 active site 290338013860 Zn binding site [ion binding]; other site 290338013861 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 290338013862 glutathione reductase; Validated; Region: PRK06116 290338013863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290338013864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290338013865 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290338013866 Haem-binding domain; Region: Haem_bd; pfam14376 290338013867 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 290338013868 trehalase; Provisional; Region: treF; PRK13270 290338013869 Trehalase; Region: Trehalase; pfam01204 290338013870 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290338013871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290338013872 NAD(P) binding site [chemical binding]; other site 290338013873 active site 290338013874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338013875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338013876 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 290338013877 putative effector binding pocket; other site 290338013878 putative dimerization interface [polypeptide binding]; other site 290338013879 inner membrane protein YhjD; Region: TIGR00766 290338013880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338013881 metabolite-proton symporter; Region: 2A0106; TIGR00883 290338013882 putative substrate translocation pore; other site 290338013883 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 290338013884 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 290338013885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338013886 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338013887 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290338013888 substrate binding site [chemical binding]; other site 290338013889 ATP binding site [chemical binding]; other site 290338013890 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290338013891 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290338013892 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 290338013893 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290338013894 putative diguanylate cyclase; Provisional; Region: PRK13561 290338013895 HAMP domain; Region: HAMP; pfam00672 290338013896 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290338013897 metal binding site [ion binding]; metal-binding site 290338013898 I-site; other site 290338013899 active site 290338013900 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290338013901 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 290338013902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338013903 TPR motif; other site 290338013904 binding surface 290338013905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338013906 TPR motif; other site 290338013907 binding surface 290338013908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290338013909 binding surface 290338013910 TPR motif; other site 290338013911 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 290338013912 endo-1,4-D-glucanase; Provisional; Region: PRK11097 290338013913 cellulose synthase regulator protein; Provisional; Region: PRK11114 290338013914 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 290338013915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290338013916 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 290338013917 DXD motif; other site 290338013918 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290338013919 PilZ domain; Region: PilZ; pfam07238 290338013920 cell division protein; Provisional; Region: PRK10037 290338013921 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290338013922 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 290338013923 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 290338013924 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 290338013925 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 290338013926 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 290338013927 methionine gamma-lyase; Provisional; Region: PRK06234 290338013928 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290338013929 homodimer interface [polypeptide binding]; other site 290338013930 substrate-cofactor binding pocket; other site 290338013931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338013932 catalytic residue [active] 290338013933 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 290338013934 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 290338013935 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 290338013936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338013937 Walker A motif; other site 290338013938 ATP binding site [chemical binding]; other site 290338013939 Walker B motif; other site 290338013940 arginine finger; other site 290338013941 Helix-turn-helix domain; Region: HTH_38; pfam13936 290338013942 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 290338013943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338013944 Walker A/P-loop; other site 290338013945 ATP binding site [chemical binding]; other site 290338013946 Q-loop/lid; other site 290338013947 ABC transporter signature motif; other site 290338013948 Walker B; other site 290338013949 D-loop; other site 290338013950 H-loop/switch region; other site 290338013951 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290338013952 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 290338013953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290338013954 Walker A/P-loop; other site 290338013955 ATP binding site [chemical binding]; other site 290338013956 Q-loop/lid; other site 290338013957 ABC transporter signature motif; other site 290338013958 Walker B; other site 290338013959 D-loop; other site 290338013960 H-loop/switch region; other site 290338013961 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290338013962 dipeptide transporter; Provisional; Region: PRK10913 290338013963 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290338013964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013965 dimer interface [polypeptide binding]; other site 290338013966 conserved gate region; other site 290338013967 putative PBP binding loops; other site 290338013968 ABC-ATPase subunit interface; other site 290338013969 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290338013970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290338013971 dimer interface [polypeptide binding]; other site 290338013972 conserved gate region; other site 290338013973 putative PBP binding loops; other site 290338013974 ABC-ATPase subunit interface; other site 290338013975 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290338013976 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290338013977 peptide binding site [polypeptide binding]; other site 290338013978 phosphoethanolamine transferase; Provisional; Region: PRK11560 290338013979 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 290338013980 Sulfatase; Region: Sulfatase; pfam00884 290338013981 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 290338013982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338013983 putative substrate translocation pore; other site 290338013984 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 290338013985 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 290338013986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290338013987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290338013988 Coenzyme A binding pocket [chemical binding]; other site 290338013989 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290338013990 molybdopterin cofactor binding site; other site 290338013991 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 290338013992 molybdopterin cofactor binding site; other site 290338013993 putative outer membrane lipoprotein; Provisional; Region: PRK10510 290338013994 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290338013995 ligand binding site [chemical binding]; other site 290338013996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338013997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290338013998 DNA binding site [nucleotide binding] 290338013999 domain linker motif; other site 290338014000 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 290338014001 putative dimerization interface [polypeptide binding]; other site 290338014002 putative ligand binding site [chemical binding]; other site 290338014003 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290338014004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290338014005 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290338014006 substrate binding site [chemical binding]; other site 290338014007 ATP binding site [chemical binding]; other site 290338014008 D-galactonate transporter; Region: 2A0114; TIGR00893 290338014009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338014010 putative substrate translocation pore; other site 290338014011 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 290338014012 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 290338014013 dimerization interface [polypeptide binding]; other site 290338014014 ligand binding site [chemical binding]; other site 290338014015 NADP binding site [chemical binding]; other site 290338014016 catalytic site [active] 290338014017 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 290338014018 Predicted transcriptional regulator [Transcription]; Region: COG2944 290338014019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290338014020 salt bridge; other site 290338014021 non-specific DNA binding site [nucleotide binding]; other site 290338014022 sequence-specific DNA binding site [nucleotide binding]; other site 290338014023 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290338014024 DNA-binding site [nucleotide binding]; DNA binding site 290338014025 RNA-binding motif; other site 290338014026 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 290338014027 DALR anticodon binding domain; Region: DALR_1; pfam05746 290338014028 anticodon binding site; other site 290338014029 tRNA binding surface [nucleotide binding]; other site 290338014030 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 290338014031 dimer interface [polypeptide binding]; other site 290338014032 motif 1; other site 290338014033 active site 290338014034 motif 2; other site 290338014035 motif 3; other site 290338014036 YsaB-like lipoprotein; Region: YsaB; pfam13983 290338014037 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 290338014038 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290338014039 Predicted membrane protein [Function unknown]; Region: COG4682 290338014040 yiaA/B two helix domain; Region: YiaAB; pfam05360 290338014041 xylulokinase; Provisional; Region: PRK15027 290338014042 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 290338014043 N- and C-terminal domain interface [polypeptide binding]; other site 290338014044 active site 290338014045 MgATP binding site [chemical binding]; other site 290338014046 catalytic site [active] 290338014047 metal binding site [ion binding]; metal-binding site 290338014048 xylulose binding site [chemical binding]; other site 290338014049 homodimer interface [polypeptide binding]; other site 290338014050 xylose isomerase; Provisional; Region: PRK05474 290338014051 xylose isomerase; Region: xylose_isom_A; TIGR02630 290338014052 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 290338014053 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290338014054 putative ligand binding site [chemical binding]; other site 290338014055 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 290338014056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290338014057 Walker A/P-loop; other site 290338014058 ATP binding site [chemical binding]; other site 290338014059 Q-loop/lid; other site 290338014060 ABC transporter signature motif; other site 290338014061 Walker B; other site 290338014062 D-loop; other site 290338014063 H-loop/switch region; other site 290338014064 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290338014065 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290338014066 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290338014067 TM-ABC transporter signature motif; other site 290338014068 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 290338014069 putative dimerization interface [polypeptide binding]; other site 290338014070 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290338014071 putative ligand binding site [chemical binding]; other site 290338014072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338014073 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290338014074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290338014075 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 290338014076 hypothetical protein; Provisional; Region: PRK10356 290338014077 alpha-amylase; Reviewed; Region: malS; PRK09505 290338014078 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290338014079 active site 290338014080 catalytic site [active] 290338014081 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 290338014082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290338014083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338014084 homodimer interface [polypeptide binding]; other site 290338014085 catalytic residue [active] 290338014086 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 290338014087 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290338014088 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290338014089 Bacterial transcriptional regulator; Region: IclR; pfam01614 290338014090 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 290338014091 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 290338014092 D-galactonate transporter; Region: 2A0114; TIGR00893 290338014093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338014094 putative substrate translocation pore; other site 290338014095 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 290338014096 putative N- and C-terminal domain interface [polypeptide binding]; other site 290338014097 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 290338014098 putative active site [active] 290338014099 MgATP binding site [chemical binding]; other site 290338014100 catalytic site [active] 290338014101 metal binding site [ion binding]; metal-binding site 290338014102 putative xylulose binding site [chemical binding]; other site 290338014103 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 290338014104 active site 290338014105 dimer interface [polypeptide binding]; other site 290338014106 magnesium binding site [ion binding]; other site 290338014107 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 290338014108 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 290338014109 AP (apurinic/apyrimidinic) site pocket; other site 290338014110 DNA interaction; other site 290338014111 Metal-binding active site; metal-binding site 290338014112 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 290338014113 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 290338014114 intersubunit interface [polypeptide binding]; other site 290338014115 active site 290338014116 Zn2+ binding site [ion binding]; other site 290338014117 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290338014118 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290338014119 NAD(P) binding site [chemical binding]; other site 290338014120 catalytic residues [active] 290338014121 putative alcohol dehydrogenase; Provisional; Region: PRK09860 290338014122 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 290338014123 dimer interface [polypeptide binding]; other site 290338014124 active site 290338014125 metal binding site [ion binding]; metal-binding site 290338014126 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 290338014127 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 290338014128 G1 box; other site 290338014129 putative GEF interaction site [polypeptide binding]; other site 290338014130 GTP/Mg2+ binding site [chemical binding]; other site 290338014131 Switch I region; other site 290338014132 G2 box; other site 290338014133 G3 box; other site 290338014134 Switch II region; other site 290338014135 G4 box; other site 290338014136 G5 box; other site 290338014137 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 290338014138 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 290338014139 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 290338014140 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 290338014141 selenocysteine synthase; Provisional; Region: PRK04311 290338014142 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 290338014143 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 290338014144 putative glutathione S-transferase; Provisional; Region: PRK10357 290338014145 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 290338014146 putative C-terminal domain interface [polypeptide binding]; other site 290338014147 putative GSH binding site (G-site) [chemical binding]; other site 290338014148 putative dimer interface [polypeptide binding]; other site 290338014149 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 290338014150 dimer interface [polypeptide binding]; other site 290338014151 N-terminal domain interface [polypeptide binding]; other site 290338014152 putative substrate binding pocket (H-site) [chemical binding]; other site 290338014153 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 290338014154 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290338014155 HlyD family secretion protein; Region: HlyD_3; pfam13437 290338014156 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 290338014157 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 290338014158 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 290338014159 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 290338014160 active site 290338014161 P-loop; other site 290338014162 phosphorylation site [posttranslational modification] 290338014163 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290338014164 active site 290338014165 phosphorylation site [posttranslational modification] 290338014166 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 290338014167 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290338014168 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290338014169 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 290338014170 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 290338014171 hypothetical protein; Provisional; Region: PRK11020 290338014172 L-lactate permease; Provisional; Region: PRK10420 290338014173 glycolate transporter; Provisional; Region: PRK09695 290338014174 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 290338014175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290338014176 DNA-binding site [nucleotide binding]; DNA binding site 290338014177 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290338014178 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 290338014179 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 290338014180 active site 290338014181 substrate binding site [chemical binding]; other site 290338014182 FMN binding site [chemical binding]; other site 290338014183 putative catalytic residues [active] 290338014184 putative rRNA methylase; Provisional; Region: PRK10358 290338014185 serine acetyltransferase; Provisional; Region: cysE; PRK11132 290338014186 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 290338014187 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290338014188 trimer interface [polypeptide binding]; other site 290338014189 active site 290338014190 substrate binding site [chemical binding]; other site 290338014191 CoA binding site [chemical binding]; other site 290338014192 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290338014193 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290338014194 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290338014195 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 290338014196 SecA binding site; other site 290338014197 Preprotein binding site; other site 290338014198 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 290338014199 GSH binding site [chemical binding]; other site 290338014200 catalytic residues [active] 290338014201 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290338014202 active site residue [active] 290338014203 phosphoglyceromutase; Provisional; Region: PRK05434 290338014204 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 290338014205 AmiB activator; Provisional; Region: PRK11637 290338014206 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 290338014207 Peptidase family M23; Region: Peptidase_M23; pfam01551 290338014208 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 290338014209 putative active site [active] 290338014210 NodB motif; other site 290338014211 putative glycosyl transferase; Provisional; Region: PRK10073 290338014212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290338014213 active site 290338014214 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 290338014215 active site 290338014216 ATP binding site [chemical binding]; other site 290338014217 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290338014218 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290338014219 NAD(P) binding site [chemical binding]; other site 290338014220 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290338014221 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 290338014222 substrate-cofactor binding pocket; other site 290338014223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290338014224 catalytic residue [active] 290338014225 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 290338014226 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 290338014227 NADP binding site [chemical binding]; other site 290338014228 homopentamer interface [polypeptide binding]; other site 290338014229 substrate binding site [chemical binding]; other site 290338014230 active site 290338014231 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290338014232 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290338014233 putative active site [active] 290338014234 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290338014235 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290338014236 putative active site [active] 290338014237 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 290338014238 O-Antigen ligase; Region: Wzy_C; pfam04932 290338014239 putative glycosyl transferase; Provisional; Region: PRK10073 290338014240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290338014241 active site 290338014242 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 290338014243 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290338014244 putative active site [active] 290338014245 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 290338014246 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 290338014247 Ligand binding site; other site 290338014248 metal-binding site 290338014249 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 290338014250 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 290338014251 Ligand binding site; other site 290338014252 metal-binding site 290338014253 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 290338014254 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 290338014255 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 290338014256 Ligand binding site; other site 290338014257 metal-binding site 290338014258 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 290338014259 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 290338014260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290338014261 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290338014262 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 290338014263 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 290338014264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290338014265 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290338014266 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290338014267 active site 290338014268 (T/H)XGH motif; other site 290338014269 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 290338014270 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 290338014271 DNA binding site [nucleotide binding] 290338014272 catalytic residue [active] 290338014273 H2TH interface [polypeptide binding]; other site 290338014274 putative catalytic residues [active] 290338014275 turnover-facilitating residue; other site 290338014276 intercalation triad [nucleotide binding]; other site 290338014277 8OG recognition residue [nucleotide binding]; other site 290338014278 putative reading head residues; other site 290338014279 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290338014280 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290338014281 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 290338014282 hypothetical protein; Reviewed; Region: PRK00024 290338014283 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 290338014284 MPN+ (JAMM) motif; other site 290338014285 Zinc-binding site [ion binding]; other site 290338014286 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290338014287 Flavoprotein; Region: Flavoprotein; pfam02441 290338014288 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 290338014289 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290338014290 trimer interface [polypeptide binding]; other site 290338014291 active site 290338014292 division inhibitor protein; Provisional; Region: slmA; PRK09480 290338014293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290338014294 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290338014295 active site 290338014296 ribonuclease PH; Reviewed; Region: rph; PRK00173 290338014297 Ribonuclease PH; Region: RNase_PH_bact; cd11362 290338014298 hexamer interface [polypeptide binding]; other site 290338014299 active site 290338014300 hypothetical protein; Provisional; Region: PRK11820 290338014301 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 290338014302 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 290338014303 Predicted membrane protein [Function unknown]; Region: COG2860 290338014304 UPF0126 domain; Region: UPF0126; pfam03458 290338014305 UPF0126 domain; Region: UPF0126; pfam03458 290338014306 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 290338014307 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 290338014308 nucleotide binding pocket [chemical binding]; other site 290338014309 K-X-D-G motif; other site 290338014310 catalytic site [active] 290338014311 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290338014312 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290338014313 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290338014314 catalytic site [active] 290338014315 G-X2-G-X-G-K; other site 290338014316 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 290338014317 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 290338014318 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290338014319 Zn2+ binding site [ion binding]; other site 290338014320 Mg2+ binding site [ion binding]; other site 290338014321 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290338014322 synthetase active site [active] 290338014323 NTP binding site [chemical binding]; other site 290338014324 metal binding site [ion binding]; metal-binding site 290338014325 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290338014326 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290338014327 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 290338014328 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290338014329 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 290338014330 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290338014331 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290338014332 generic binding surface II; other site 290338014333 ssDNA binding site; other site 290338014334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290338014335 ATP binding site [chemical binding]; other site 290338014336 putative Mg++ binding site [ion binding]; other site 290338014337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290338014338 nucleotide binding region [chemical binding]; other site 290338014339 ATP-binding site [chemical binding]; other site 290338014340 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 290338014341 AsmA family; Region: AsmA; pfam05170 290338014342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290338014343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290338014344 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 290338014345 putative effector binding pocket; other site 290338014346 dimerization interface [polypeptide binding]; other site 290338014347 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 290338014348 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 290338014349 putative NAD(P) binding site [chemical binding]; other site 290338014350 dimer interface [polypeptide binding]; other site 290338014351 Predicted ATPase [General function prediction only]; Region: COG4637 290338014352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338014353 Walker A/P-loop; other site 290338014354 ATP binding site [chemical binding]; other site 290338014355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290338014356 ABC transporter signature motif; other site 290338014357 Walker B; other site 290338014358 D-loop; other site 290338014359 H-loop/switch region; other site 290338014360 EamA-like transporter family; Region: EamA; pfam00892 290338014361 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 290338014362 EamA-like transporter family; Region: EamA; pfam00892 290338014363 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 290338014364 DNA binding residues [nucleotide binding] 290338014365 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 290338014366 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338014367 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338014368 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338014369 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 290338014370 PapC N-terminal domain; Region: PapC_N; pfam13954 290338014371 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 290338014372 PapC C-terminal domain; Region: PapC_C; pfam13953 290338014373 putative chaperone protein EcpD; Provisional; Region: PRK09926 290338014374 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290338014375 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 290338014376 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 290338014377 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 290338014378 lipoprotein, YaeC family; Region: TIGR00363 290338014379 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 290338014380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290338014381 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 290338014382 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 290338014383 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 290338014384 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 290338014385 active site 290338014386 phosphorylation site [posttranslational modification] 290338014387 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 290338014388 active pocket/dimerization site; other site 290338014389 active site 290338014390 phosphorylation site [posttranslational modification] 290338014391 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 290338014392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290338014393 Walker A motif; other site 290338014394 ATP binding site [chemical binding]; other site 290338014395 Walker B motif; other site 290338014396 arginine finger; other site 290338014397 Transcriptional antiterminator [Transcription]; Region: COG3933 290338014398 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 290338014399 active site 290338014400 active pocket/dimerization site; other site 290338014401 phosphorylation site [posttranslational modification] 290338014402 PRD domain; Region: PRD; pfam00874 290338014403 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 290338014404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290338014405 putative substrate translocation pore; other site 290338014406 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 290338014407 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290338014408 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290338014409 Bacterial transcriptional regulator; Region: IclR; pfam01614 290338014410 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290338014411 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290338014412 inhibitor site; inhibition site 290338014413 active site 290338014414 dimer interface [polypeptide binding]; other site 290338014415 catalytic residue [active] 290338014416 Rop protein; Region: Rop; pfam01815 290338014417 Replication-relaxation; Region: Replic_Relax; pfam13814 290338014418 AAA-like domain; Region: AAA_10; pfam12846 290338014419 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 290338014420 Lysis protein; Region: Lysis_col; pfam02402 290338014421 Cloacin immunity protein; Region: Cloacin_immun; pfam03513 290338014422 Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515 290338014423 Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570 290338014424 Cytotoxic; Region: Cytotoxic; pfam09000 290338014425 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 290338014426 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 290338014427 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290338014428 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 290338014429 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026