-- dump date 20120504_134517 -- class Genbank::misc_feature -- table misc_feature_note -- id note 508765000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 508765000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 508765000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000004 Walker A motif; other site 508765000005 ATP binding site [chemical binding]; other site 508765000006 Walker B motif; other site 508765000007 arginine finger; other site 508765000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 508765000009 DnaA box-binding interface [nucleotide binding]; other site 508765000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 508765000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 508765000012 putative DNA binding surface [nucleotide binding]; other site 508765000013 dimer interface [polypeptide binding]; other site 508765000014 beta-clamp/clamp loader binding surface; other site 508765000015 beta-clamp/translesion DNA polymerase binding surface; other site 508765000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508765000017 recombination protein F; Reviewed; Region: recF; PRK00064 508765000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 508765000019 Walker A/P-loop; other site 508765000020 ATP binding site [chemical binding]; other site 508765000021 Q-loop/lid; other site 508765000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765000023 ABC transporter signature motif; other site 508765000024 Walker B; other site 508765000025 D-loop; other site 508765000026 H-loop/switch region; other site 508765000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 508765000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 508765000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 508765000030 anchoring element; other site 508765000031 dimer interface [polypeptide binding]; other site 508765000032 ATP binding site [chemical binding]; other site 508765000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 508765000034 active site 508765000035 putative metal-binding site [ion binding]; other site 508765000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 508765000037 DNA gyrase subunit A; Validated; Region: PRK05560 508765000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 508765000039 CAP-like domain; other site 508765000040 active site 508765000041 primary dimer interface [polypeptide binding]; other site 508765000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765000048 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765000049 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 508765000050 Helix-turn-helix domains; Region: HTH; cl00088 508765000051 3H domain; Region: 3H; pfam02829 508765000052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765000053 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 508765000054 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 508765000055 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 508765000056 T-box leader 508765000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 508765000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 508765000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 508765000060 dimer interface [polypeptide binding]; other site 508765000061 active site 508765000062 motif 1; other site 508765000063 motif 2; other site 508765000064 motif 3; other site 508765000065 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765000066 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765000067 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 508765000068 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 508765000069 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 508765000070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765000071 Family description; Region: UvrD_C_2; cl15862 508765000072 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 508765000073 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 508765000074 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 508765000075 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765000076 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508765000077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765000078 dimer interface [polypeptide binding]; other site 508765000079 phosphorylation site [posttranslational modification] 508765000080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000081 ATP binding site [chemical binding]; other site 508765000082 Mg2+ binding site [ion binding]; other site 508765000083 G-X-G motif; other site 508765000084 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 508765000085 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765000086 Int/Topo IB signature motif; other site 508765000087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765000088 non-specific DNA binding site [nucleotide binding]; other site 508765000089 salt bridge; other site 508765000090 sequence-specific DNA binding site [nucleotide binding]; other site 508765000091 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765000092 DNA binding residues [nucleotide binding] 508765000093 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 508765000094 Phage-related protein [Function unknown]; Region: COG4695; cl01923 508765000095 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 508765000096 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 508765000097 Phage capsid family; Region: Phage_capsid; pfam05065 508765000098 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 508765000099 oligomerization interface [polypeptide binding]; other site 508765000100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765000101 DNA binding site [nucleotide binding] 508765000102 Int/Topo IB signature motif; other site 508765000103 active site 508765000104 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 508765000105 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 508765000106 Phage Terminase; Region: Terminase_1; pfam03354 508765000107 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 508765000108 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765000109 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765000110 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 508765000111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765000112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765000113 DNA binding residues [nucleotide binding] 508765000114 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 508765000115 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 508765000116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765000117 Helix-turn-helix domains; Region: HTH; cl00088 508765000118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765000119 catalytic loop [active] 508765000120 iron binding site [ion binding]; other site 508765000121 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508765000122 4Fe-4S binding domain; Region: Fer4; cl02805 508765000123 4Fe-4S binding domain; Region: Fer4; cl02805 508765000124 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765000125 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 508765000126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765000127 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765000128 active site 508765000129 motif I; other site 508765000130 motif II; other site 508765000131 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765000132 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 508765000133 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765000134 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765000135 ABC transporter; Region: ABC_tran_2; pfam12848 508765000136 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765000137 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 508765000138 Haemolysin-III related; Region: HlyIII; cl03831 508765000139 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 508765000140 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 508765000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 508765000142 Nucleoside recognition; Region: Gate; cl00486 508765000143 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765000144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765000145 dimer interface [polypeptide binding]; other site 508765000146 putative CheW interface [polypeptide binding]; other site 508765000147 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 508765000148 nucleotide binding site [chemical binding]; other site 508765000149 homotetrameric interface [polypeptide binding]; other site 508765000150 putative phosphate binding site [ion binding]; other site 508765000151 putative allosteric binding site; other site 508765000152 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 508765000153 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 508765000154 putative catalytic cysteine [active] 508765000155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765000156 Coenzyme A binding pocket [chemical binding]; other site 508765000157 Predicted membrane protein [Function unknown]; Region: COG3428 508765000158 Bacterial PH domain; Region: DUF304; cl01348 508765000159 Bacterial PH domain; Region: DUF304; cl01348 508765000160 Predicted membrane protein [Function unknown]; Region: COG3428 508765000161 Bacterial PH domain; Region: DUF304; cl01348 508765000162 short chain dehydrogenase; Provisional; Region: PRK08251 508765000163 classical (c) SDRs; Region: SDR_c; cd05233 508765000164 NAD(P) binding site [chemical binding]; other site 508765000165 active site 508765000166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765000167 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765000168 active site 508765000169 motif I; other site 508765000170 motif II; other site 508765000171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765000172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765000173 dimer interface [polypeptide binding]; other site 508765000174 putative CheW interface [polypeptide binding]; other site 508765000175 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 508765000176 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 508765000177 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 508765000178 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 508765000179 catalytic site [active] 508765000180 subunit interface [polypeptide binding]; other site 508765000181 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 508765000182 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765000183 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765000184 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 508765000185 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765000186 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765000187 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 508765000188 IMP binding site; other site 508765000189 dimer interface [polypeptide binding]; other site 508765000190 interdomain contacts; other site 508765000191 partial ornithine binding site; other site 508765000192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765000193 Zn2+ binding site [ion binding]; other site 508765000194 Mg2+ binding site [ion binding]; other site 508765000195 glutamine synthetase, type I; Region: GlnA; TIGR00653 508765000196 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 508765000197 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 508765000198 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 508765000199 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 508765000200 active site 508765000201 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 508765000202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765000203 non-specific DNA binding site [nucleotide binding]; other site 508765000204 salt bridge; other site 508765000205 sequence-specific DNA binding site [nucleotide binding]; other site 508765000206 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 508765000207 Catalytic site [active] 508765000208 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765000209 active site 508765000210 catalytic triad [active] 508765000211 Stage II sporulation protein; Region: SpoIID; pfam08486 508765000212 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 508765000213 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 508765000214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765000215 FeS/SAM binding site; other site 508765000216 Uncharacterized membrane protein [Function unknown]; Region: COG3949 508765000217 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 508765000218 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 508765000219 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 508765000220 PUA domain; Region: PUA; cl00607 508765000221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765000222 S-adenosylmethionine binding site [chemical binding]; other site 508765000223 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765000224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765000225 active site 508765000226 phosphorylation site [posttranslational modification] 508765000227 intermolecular recognition site; other site 508765000228 dimerization interface [polypeptide binding]; other site 508765000229 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765000230 DNA binding site [nucleotide binding] 508765000231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765000232 dimer interface [polypeptide binding]; other site 508765000233 phosphorylation site [posttranslational modification] 508765000234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000235 ATP binding site [chemical binding]; other site 508765000236 Mg2+ binding site [ion binding]; other site 508765000237 G-X-G motif; other site 508765000238 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 508765000239 putative metal binding residues [ion binding]; other site 508765000240 signature motif; other site 508765000241 dimer interface [polypeptide binding]; other site 508765000242 polyP binding site; other site 508765000243 active site 508765000244 substrate binding site [chemical binding]; other site 508765000245 acceptor-phosphate pocket; other site 508765000246 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508765000247 MgtC family; Region: MgtC; pfam02308 508765000248 CotH protein; Region: CotH; pfam08757 508765000249 CotH protein; Region: CotH; pfam08757 508765000250 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 508765000251 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 508765000252 active site 508765000253 metal binding site [ion binding]; metal-binding site 508765000254 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508765000255 T-box leader 508765000256 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 508765000257 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 508765000258 HIGH motif; other site 508765000259 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 508765000260 active site 508765000261 KMSKS motif; other site 508765000262 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 508765000263 tRNA binding surface [nucleotide binding]; other site 508765000264 anticodon binding site; other site 508765000265 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 508765000266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765000267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765000268 DNA binding site [nucleotide binding] 508765000269 domain linker motif; other site 508765000270 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765000271 dimerization interface [polypeptide binding]; other site 508765000272 ligand binding site [chemical binding]; other site 508765000273 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765000274 MatE; Region: MatE; cl10513 508765000275 MatE; Region: MatE; cl10513 508765000276 Nucleoside recognition; Region: Gate; cl00486 508765000277 Nucleoside recognition; Region: Gate; cl00486 508765000278 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 508765000279 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765000280 Lysine riboswitch 508765000281 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 508765000282 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 508765000283 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 508765000284 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 508765000285 active site 508765000286 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 508765000287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000288 Walker A motif; other site 508765000289 ATP binding site [chemical binding]; other site 508765000290 Walker B motif; other site 508765000291 arginine finger; other site 508765000292 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508765000293 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765000294 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 508765000295 amphipathic channel; other site 508765000296 Asn-Pro-Ala signature motifs; other site 508765000297 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 508765000298 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 508765000299 DAK2 domain; Region: Dak2; cl03685 508765000300 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 508765000301 T-box leader 508765000302 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 508765000303 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 508765000304 HIGH motif; other site 508765000305 active site 508765000306 KMSKS motif; other site 508765000307 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 508765000308 tRNA binding surface [nucleotide binding]; other site 508765000309 anticodon binding site; other site 508765000310 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 508765000311 dimer interface [polypeptide binding]; other site 508765000312 putative tRNA-binding site [nucleotide binding]; other site 508765000313 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 508765000314 active site 508765000315 Domain of unknown function (DUF348); Region: DUF348; pfam03990 508765000316 G5 domain; Region: G5; pfam07501 508765000317 3D domain; Region: 3D; cl01439 508765000318 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 508765000319 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 508765000320 putative active site [active] 508765000321 putative metal binding site [ion binding]; other site 508765000322 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 508765000323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765000324 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 508765000325 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 508765000326 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 508765000327 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765000328 Helix-turn-helix domains; Region: HTH; cl00088 508765000329 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765000330 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 508765000331 ATP cone domain; Region: ATP-cone; pfam03477 508765000332 Class III ribonucleotide reductase; Region: RNR_III; cd01675 508765000333 effector binding site; other site 508765000334 active site 508765000335 Zn binding site [ion binding]; other site 508765000336 glycine loop; other site 508765000337 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 508765000338 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 508765000339 active site 508765000340 catalytic residues [active] 508765000341 metal binding site [ion binding]; metal-binding site 508765000342 aconitate hydratase; Validated; Region: PRK07229 508765000343 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 508765000344 substrate binding site [chemical binding]; other site 508765000345 ligand binding site [chemical binding]; other site 508765000346 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 508765000347 substrate binding site [chemical binding]; other site 508765000348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765000349 metal binding site [ion binding]; metal-binding site 508765000350 active site 508765000351 I-site; other site 508765000352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765000353 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 508765000354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765000355 FeS/SAM binding site; other site 508765000356 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 508765000357 active site 508765000358 DNA binding site [nucleotide binding] 508765000359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765000360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765000361 DNA binding site [nucleotide binding] 508765000362 domain linker motif; other site 508765000363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765000364 dimerization interface [polypeptide binding]; other site 508765000365 ligand binding site [chemical binding]; other site 508765000366 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765000367 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765000368 Ca binding site [ion binding]; other site 508765000369 active site 508765000370 catalytic site [active] 508765000371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765000372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765000373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765000374 dimer interface [polypeptide binding]; other site 508765000375 conserved gate region; other site 508765000376 putative PBP binding loops; other site 508765000377 ABC-ATPase subunit interface; other site 508765000378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765000379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765000380 dimer interface [polypeptide binding]; other site 508765000381 conserved gate region; other site 508765000382 putative PBP binding loops; other site 508765000383 ABC-ATPase subunit interface; other site 508765000384 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 508765000385 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 508765000386 putative active site [active] 508765000387 putative metal binding site [ion binding]; other site 508765000388 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 508765000389 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 508765000390 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 508765000391 putative dimer interface [polypeptide binding]; other site 508765000392 putative anticodon binding site; other site 508765000393 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 508765000394 homodimer interface [polypeptide binding]; other site 508765000395 motif 1; other site 508765000396 motif 2; other site 508765000397 active site 508765000398 motif 3; other site 508765000399 T-box leader 508765000400 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 508765000401 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765000402 active site 508765000403 metal binding site [ion binding]; metal-binding site 508765000404 homotetramer interface [polypeptide binding]; other site 508765000405 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 508765000406 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 508765000407 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 508765000408 active site 508765000409 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 508765000410 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508765000411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765000412 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765000413 pur operon repressor; Provisional; Region: PRK09213 508765000414 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 508765000415 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765000416 active site 508765000417 SpoVG; Region: SpoVG; cl00915 508765000418 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 508765000419 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 508765000420 Substrate binding site; other site 508765000421 Mg++ binding site; other site 508765000422 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 508765000423 active site 508765000424 substrate binding site [chemical binding]; other site 508765000425 CoA binding site [chemical binding]; other site 508765000426 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 508765000427 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 508765000428 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765000429 active site 508765000430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765000431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765000432 active site 508765000433 phosphorylation site [posttranslational modification] 508765000434 intermolecular recognition site; other site 508765000435 dimerization interface [polypeptide binding]; other site 508765000436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765000437 DNA binding site [nucleotide binding] 508765000438 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 508765000439 putative active site [active] 508765000440 catalytic residue [active] 508765000441 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 508765000442 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508765000443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765000444 ATP binding site [chemical binding]; other site 508765000445 putative Mg++ binding site [ion binding]; other site 508765000446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765000447 nucleotide binding region [chemical binding]; other site 508765000448 ATP-binding site [chemical binding]; other site 508765000449 TRCF domain; Region: TRCF; cl04088 508765000450 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 508765000451 SurA N-terminal domain; Region: SurA_N_3; cl07813 508765000452 PPIC-type PPIASE domain; Region: Rotamase; cl08278 508765000453 stage V sporulation protein T; Region: spore_V_T; TIGR02851 508765000454 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 508765000455 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508765000456 MatE; Region: MatE; cl10513 508765000457 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 508765000458 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765000459 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 508765000460 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 508765000461 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 508765000462 IHF dimer interface [polypeptide binding]; other site 508765000463 IHF - DNA interface [nucleotide binding]; other site 508765000464 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508765000465 YabP family; Region: YabP; cl06766 508765000466 Septum formation initiator; Region: DivIC; cl11433 508765000467 hypothetical protein; Provisional; Region: PRK05807 508765000468 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 508765000469 RNA binding site [nucleotide binding]; other site 508765000470 stage II sporulation protein E; Region: spore_II_E; TIGR02865 508765000471 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 508765000472 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 508765000473 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 508765000474 Ligand Binding Site [chemical binding]; other site 508765000475 B3/4 domain; Region: B3_4; cl11458 508765000476 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765000477 active site 508765000478 FtsH Extracellular; Region: FtsH_ext; pfam06480 508765000479 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 508765000480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000481 Walker A motif; other site 508765000482 ATP binding site [chemical binding]; other site 508765000483 Walker B motif; other site 508765000484 arginine finger; other site 508765000485 Peptidase family M41; Region: Peptidase_M41; pfam01434 508765000486 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 508765000487 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 508765000488 Potassium binding sites [ion binding]; other site 508765000489 Cesium cation binding sites [ion binding]; other site 508765000490 Type III pantothenate kinase; Region: Pan_kinase; cl09130 508765000491 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 508765000492 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 508765000493 FMN binding site [chemical binding]; other site 508765000494 active site 508765000495 catalytic residues [active] 508765000496 substrate binding site [chemical binding]; other site 508765000497 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 508765000498 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 508765000499 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 508765000500 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 508765000501 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 508765000502 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 508765000503 dimer interface [polypeptide binding]; other site 508765000504 putative anticodon binding site; other site 508765000505 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 508765000506 motif 1; other site 508765000507 active site 508765000508 motif 2; other site 508765000509 motif 3; other site 508765000510 T-box leader 508765000511 glycyl-tRNA synthetase; Provisional; Region: PRK04173 508765000512 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 508765000513 motif 1; other site 508765000514 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 508765000515 active site 508765000516 motif 2; other site 508765000517 motif 3; other site 508765000518 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 508765000519 anticodon binding site; other site 508765000520 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 508765000521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765000522 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765000523 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765000524 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 508765000525 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 508765000526 amidohydrolase; Region: amidohydrolases; TIGR01891 508765000527 metal binding site [ion binding]; metal-binding site 508765000528 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 508765000529 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 508765000530 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 508765000531 TMP-binding site; other site 508765000532 ATP-binding site [chemical binding]; other site 508765000533 Nitrogen regulatory protein P-II; Region: P-II; cl00412 508765000534 DNA polymerase III subunit delta'; Validated; Region: PRK05564 508765000535 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765000536 PSP1 C-terminal conserved region; Region: PSP1; cl00770 508765000537 hypothetical protein; Provisional; Region: PRK13795 508765000538 4Fe-4S binding domain; Region: Fer4; cl02805 508765000539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765000540 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 508765000541 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 508765000542 UvrB/uvrC motif; Region: UVR; pfam02151 508765000543 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 508765000544 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 508765000545 ADP binding site [chemical binding]; other site 508765000546 phosphagen binding site; other site 508765000547 substrate specificity loop; other site 508765000548 Clp protease ATP binding subunit; Region: clpC; CHL00095 508765000549 Clp amino terminal domain; Region: Clp_N; pfam02861 508765000550 Clp amino terminal domain; Region: Clp_N; pfam02861 508765000551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000552 Walker A motif; other site 508765000553 ATP binding site [chemical binding]; other site 508765000554 Walker B motif; other site 508765000555 arginine finger; other site 508765000556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765000557 Walker A motif; other site 508765000558 ATP binding site [chemical binding]; other site 508765000559 Walker B motif; other site 508765000560 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 508765000561 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 508765000562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765000563 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 508765000564 catalytic residues [active] 508765000565 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 508765000566 catalytic residues [active] 508765000567 DNA repair protein RadA; Provisional; Region: PRK11823 508765000568 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 508765000569 Walker A motif/ATP binding site; other site 508765000570 ATP binding site [chemical binding]; other site 508765000571 Walker B motif; other site 508765000572 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 508765000573 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 508765000574 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 508765000575 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 508765000576 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 508765000577 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 508765000578 putative active site [active] 508765000579 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 508765000580 substrate binding site; other site 508765000581 dimer interface; other site 508765000582 T-box leader 508765000583 prolyl-tRNA synthetase; Provisional; Region: PRK09194 508765000584 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 508765000585 dimer interface [polypeptide binding]; other site 508765000586 motif 1; other site 508765000587 active site 508765000588 motif 2; other site 508765000589 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 508765000590 putative deacylase active site [active] 508765000591 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 508765000592 active site 508765000593 motif 3; other site 508765000594 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 508765000595 anticodon binding site; other site 508765000596 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 508765000597 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 508765000598 active site 508765000599 HIGH motif; other site 508765000600 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 508765000601 KMSKS motif; other site 508765000602 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 508765000603 tRNA binding surface [nucleotide binding]; other site 508765000604 anticodon binding site; other site 508765000605 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 508765000606 dimerization interface [polypeptide binding]; other site 508765000607 active site 508765000608 metal binding site [ion binding]; metal-binding site 508765000609 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 508765000610 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 508765000611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 508765000612 YacP-like NYN domain; Region: NYN_YacP; cl01491 508765000613 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 508765000614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765000615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765000616 elongation factor Tu; Reviewed; Region: PRK00049 508765000617 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 508765000618 G1 box; other site 508765000619 GEF interaction site [polypeptide binding]; other site 508765000620 GTP/Mg2+ binding site [chemical binding]; other site 508765000621 Switch I region; other site 508765000622 G2 box; other site 508765000623 G3 box; other site 508765000624 Switch II region; other site 508765000625 G4 box; other site 508765000626 G5 box; other site 508765000627 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 508765000628 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 508765000629 Antibiotic Binding Site [chemical binding]; other site 508765000630 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 508765000631 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 508765000632 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 508765000633 putative homodimer interface [polypeptide binding]; other site 508765000634 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 508765000635 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 508765000636 23S rRNA interface [nucleotide binding]; other site 508765000637 L7/L12 interface [polypeptide binding]; other site 508765000638 putative thiostrepton binding site; other site 508765000639 L25 interface [polypeptide binding]; other site 508765000640 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 508765000641 mRNA/rRNA interface [nucleotide binding]; other site 508765000642 Ribosomal protein L10 leader 508765000643 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 508765000644 23S rRNA interface [nucleotide binding]; other site 508765000645 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 508765000646 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 508765000647 core dimer interface [polypeptide binding]; other site 508765000648 peripheral dimer interface [polypeptide binding]; other site 508765000649 L10 interface [polypeptide binding]; other site 508765000650 L11 interface [polypeptide binding]; other site 508765000651 putative EF-Tu interaction site [polypeptide binding]; other site 508765000652 putative EF-G interaction site [polypeptide binding]; other site 508765000653 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 508765000654 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 508765000655 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 508765000656 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 508765000657 RPB1 interaction site [polypeptide binding]; other site 508765000658 RPB10 interaction site [polypeptide binding]; other site 508765000659 RPB11 interaction site [polypeptide binding]; other site 508765000660 RPB3 interaction site [polypeptide binding]; other site 508765000661 RPB12 interaction site [polypeptide binding]; other site 508765000662 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 508765000663 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 508765000664 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 508765000665 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 508765000666 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 508765000667 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 508765000668 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 508765000669 G-loop; other site 508765000670 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 508765000671 DNA binding site [nucleotide binding] 508765000672 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 508765000673 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 508765000674 S17 interaction site [polypeptide binding]; other site 508765000675 S8 interaction site; other site 508765000676 16S rRNA interaction site [nucleotide binding]; other site 508765000677 streptomycin interaction site [chemical binding]; other site 508765000678 23S rRNA interaction site [nucleotide binding]; other site 508765000679 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 508765000680 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 508765000681 elongation factor G; Reviewed; Region: PRK00007 508765000682 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 508765000683 G1 box; other site 508765000684 putative GEF interaction site [polypeptide binding]; other site 508765000685 GTP/Mg2+ binding site [chemical binding]; other site 508765000686 Switch I region; other site 508765000687 G2 box; other site 508765000688 G3 box; other site 508765000689 Switch II region; other site 508765000690 G4 box; other site 508765000691 G5 box; other site 508765000692 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 508765000693 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 508765000694 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 508765000695 elongation factor Tu; Reviewed; Region: PRK00049 508765000696 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 508765000697 G1 box; other site 508765000698 GEF interaction site [polypeptide binding]; other site 508765000699 GTP/Mg2+ binding site [chemical binding]; other site 508765000700 Switch I region; other site 508765000701 G2 box; other site 508765000702 G3 box; other site 508765000703 Switch II region; other site 508765000704 G4 box; other site 508765000705 G5 box; other site 508765000706 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 508765000707 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 508765000708 Antibiotic Binding Site [chemical binding]; other site 508765000709 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 508765000710 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 508765000711 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 508765000712 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 508765000713 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 508765000714 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 508765000715 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 508765000716 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 508765000717 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 508765000718 putative translocon binding site; other site 508765000719 protein-rRNA interface [nucleotide binding]; other site 508765000720 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 508765000721 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 508765000722 G-X-X-G motif; other site 508765000723 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 508765000724 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 508765000725 23S rRNA interface [nucleotide binding]; other site 508765000726 5S rRNA interface [nucleotide binding]; other site 508765000727 putative antibiotic binding site [chemical binding]; other site 508765000728 L25 interface [polypeptide binding]; other site 508765000729 L27 interface [polypeptide binding]; other site 508765000730 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 508765000731 23S rRNA interface [nucleotide binding]; other site 508765000732 putative translocon interaction site; other site 508765000733 signal recognition particle (SRP54) interaction site; other site 508765000734 L23 interface [polypeptide binding]; other site 508765000735 trigger factor interaction site; other site 508765000736 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 508765000737 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 508765000738 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 508765000739 KOW motif; Region: KOW; cl00354 508765000740 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 508765000741 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 508765000742 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 508765000743 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 508765000744 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 508765000745 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 508765000746 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 508765000747 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 508765000748 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 508765000749 5S rRNA interface [nucleotide binding]; other site 508765000750 L27 interface [polypeptide binding]; other site 508765000751 23S rRNA interface [nucleotide binding]; other site 508765000752 L5 interface [polypeptide binding]; other site 508765000753 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 508765000754 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 508765000755 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 508765000756 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 508765000757 23S rRNA binding site [nucleotide binding]; other site 508765000758 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 508765000759 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 508765000760 SecY translocase; Region: SecY; pfam00344 508765000761 adenylate kinase; Reviewed; Region: adk; PRK00279 508765000762 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 508765000763 AMP-binding site [chemical binding]; other site 508765000764 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 508765000765 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 508765000766 active site 508765000767 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 508765000768 rRNA binding site [nucleotide binding]; other site 508765000769 predicted 30S ribosome binding site; other site 508765000770 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 508765000771 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 508765000772 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 508765000773 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 508765000774 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 508765000775 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 508765000776 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765000777 RNA binding surface [nucleotide binding]; other site 508765000778 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 508765000779 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 508765000780 alphaNTD homodimer interface [polypeptide binding]; other site 508765000781 alphaNTD - beta interaction site [polypeptide binding]; other site 508765000782 alphaNTD - beta' interaction site [polypeptide binding]; other site 508765000783 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 508765000784 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 508765000785 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 508765000786 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 508765000787 Walker A/P-loop; other site 508765000788 ATP binding site [chemical binding]; other site 508765000789 Q-loop/lid; other site 508765000790 ABC transporter signature motif; other site 508765000791 Walker B; other site 508765000792 D-loop; other site 508765000793 H-loop/switch region; other site 508765000794 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 508765000795 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 508765000796 Walker A/P-loop; other site 508765000797 ATP binding site [chemical binding]; other site 508765000798 Q-loop/lid; other site 508765000799 ABC transporter signature motif; other site 508765000800 Walker B; other site 508765000801 D-loop; other site 508765000802 H-loop/switch region; other site 508765000803 Cobalt transport protein; Region: CbiQ; cl00463 508765000804 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 508765000805 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 508765000806 dimerization interface 3.5A [polypeptide binding]; other site 508765000807 active site 508765000808 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 508765000809 23S rRNA interface [nucleotide binding]; other site 508765000810 L3 interface [polypeptide binding]; other site 508765000811 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 508765000812 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 508765000813 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765000814 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765000815 PhoU domain; Region: PhoU; pfam01895 508765000816 PhoU domain; Region: PhoU; pfam01895 508765000817 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765000818 active site 508765000819 metal binding site [ion binding]; metal-binding site 508765000820 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 508765000821 Fumarase C-terminus; Region: Fumerase_C; cl00795 508765000822 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508765000823 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765000824 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765000825 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 508765000826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765000827 TPR motif; other site 508765000828 TPR repeat; Region: TPR_11; pfam13414 508765000829 binding surface 508765000830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508765000831 binding surface 508765000832 TPR motif; other site 508765000833 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765000834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765000835 active site 508765000836 phosphorylation site [posttranslational modification] 508765000837 intermolecular recognition site; other site 508765000838 dimerization interface [polypeptide binding]; other site 508765000839 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765000840 DNA binding site [nucleotide binding] 508765000841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765000842 dimer interface [polypeptide binding]; other site 508765000843 phosphorylation site [posttranslational modification] 508765000844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765000845 ATP binding site [chemical binding]; other site 508765000846 Mg2+ binding site [ion binding]; other site 508765000847 G-X-G motif; other site 508765000848 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 508765000849 Class I ribonucleotide reductase; Region: RNR_I; cd01679 508765000850 active site 508765000851 dimer interface [polypeptide binding]; other site 508765000852 catalytic residues [active] 508765000853 effector binding site; other site 508765000854 R2 peptide binding site; other site 508765000855 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 508765000856 dimer interface [polypeptide binding]; other site 508765000857 putative radical transfer pathway; other site 508765000858 diiron center [ion binding]; other site 508765000859 tyrosyl radical; other site 508765000860 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 508765000861 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 508765000862 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 508765000863 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 508765000864 Chromate transporter; Region: Chromate_transp; pfam02417 508765000865 Chromate transporter; Region: Chromate_transp; pfam02417 508765000866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508765000867 binding surface 508765000868 TPR motif; other site 508765000869 isoaspartyl dipeptidase; Provisional; Region: PRK10657 508765000870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765000871 active site 508765000872 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 508765000873 Uncharacterized conserved protein [Function unknown]; Region: COG1624 508765000874 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 508765000875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 508765000876 YbbR-like protein; Region: YbbR; pfam07949 508765000877 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 508765000878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765000879 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 508765000880 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 508765000881 Acetokinase family; Region: Acetate_kinase; cl01029 508765000882 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 508765000883 Helix-turn-helix domains; Region: HTH; cl00088 508765000884 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 508765000885 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 508765000886 active site 508765000887 substrate binding site [chemical binding]; other site 508765000888 metal binding site [ion binding]; metal-binding site 508765000889 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508765000890 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 508765000891 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508765000892 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765000893 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 508765000894 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 508765000895 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 508765000896 active site 508765000897 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000898 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000899 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000900 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 508765000901 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 508765000902 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 508765000903 putative valine binding site [chemical binding]; other site 508765000904 dimer interface [polypeptide binding]; other site 508765000905 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 508765000906 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 508765000907 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 508765000908 substrate binding site [chemical binding]; other site 508765000909 ligand binding site [chemical binding]; other site 508765000910 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 508765000911 substrate binding site [chemical binding]; other site 508765000912 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 508765000913 tartrate dehydrogenase; Provisional; Region: PRK08194 508765000914 Dehydratase family; Region: ILVD_EDD; cl00340 508765000915 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 508765000916 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765000917 PYR/PP interface [polypeptide binding]; other site 508765000918 dimer interface [polypeptide binding]; other site 508765000919 TPP binding site [chemical binding]; other site 508765000920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 508765000921 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 508765000922 TPP-binding site [chemical binding]; other site 508765000923 dimer interface [polypeptide binding]; other site 508765000924 ketol-acid reductoisomerase; Provisional; Region: PRK05479 508765000925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765000926 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 508765000927 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 508765000928 GIY-YIG motif/motif A; other site 508765000929 putative active site [active] 508765000930 putative metal binding site [ion binding]; other site 508765000931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765000932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765000933 DNA binding site [nucleotide binding] 508765000934 domain linker motif; other site 508765000935 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 508765000936 putative dimerization interface [polypeptide binding]; other site 508765000937 putative ligand binding site [chemical binding]; other site 508765000938 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765000939 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765000940 Ca binding site [ion binding]; other site 508765000941 active site 508765000942 catalytic site [active] 508765000943 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 508765000944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765000945 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765000946 active site turn [active] 508765000947 phosphorylation site [posttranslational modification] 508765000948 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 508765000949 putative catalytic site [active] 508765000950 putative metal binding site [ion binding]; other site 508765000951 putative phosphate binding site [ion binding]; other site 508765000952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765000953 Helix-turn-helix domains; Region: HTH; cl00088 508765000954 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 508765000955 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 508765000956 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 508765000957 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 508765000958 Protein export membrane protein; Region: SecD_SecF; cl14618 508765000959 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 508765000960 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765000961 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765000962 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 508765000963 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 508765000964 glutaminase active site [active] 508765000965 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 508765000966 dimer interface [polypeptide binding]; other site 508765000967 active site 508765000968 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 508765000969 dimer interface [polypeptide binding]; other site 508765000970 active site 508765000971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765000972 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 508765000973 ligand binding site [chemical binding]; other site 508765000974 flexible hinge region; other site 508765000975 Helix-turn-helix domains; Region: HTH; cl00088 508765000976 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765000977 MatE; Region: MatE; cl10513 508765000978 MatE; Region: MatE; cl10513 508765000979 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 508765000980 active site 508765000981 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 508765000982 substrate binding site [chemical binding]; other site 508765000983 metal binding site [ion binding]; metal-binding site 508765000984 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 508765000985 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 508765000986 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 508765000987 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 508765000988 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 508765000989 active site clefts [active] 508765000990 zinc binding site [ion binding]; other site 508765000991 dimer interface [polypeptide binding]; other site 508765000992 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 508765000993 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 508765000994 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 508765000995 homodimer interface [polypeptide binding]; other site 508765000996 substrate-cofactor binding pocket; other site 508765000997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765000998 catalytic residue [active] 508765000999 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 508765001000 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 508765001001 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 508765001002 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 508765001003 active site 508765001004 dimer interface [polypeptide binding]; other site 508765001005 motif 1; other site 508765001006 motif 2; other site 508765001007 motif 3; other site 508765001008 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 508765001009 anticodon binding site; other site 508765001010 T-box leader 508765001011 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 508765001012 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 508765001013 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 508765001014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001015 putative substrate translocation pore; other site 508765001016 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 508765001017 homotrimer interaction site [polypeptide binding]; other site 508765001018 zinc binding site [ion binding]; other site 508765001019 CDP-binding sites; other site 508765001020 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 508765001021 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 508765001022 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 508765001023 putative active site [active] 508765001024 putative metal binding site [ion binding]; other site 508765001025 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508765001026 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508765001027 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765001028 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765001029 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 508765001030 biotin synthase; Provisional; Region: PRK07094 508765001031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765001032 FeS/SAM binding site; other site 508765001033 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 508765001034 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 508765001035 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765001036 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765001037 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765001038 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765001039 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765001040 Transcriptional regulators [Transcription]; Region: FadR; COG2186 508765001041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765001042 DNA-binding site [nucleotide binding]; DNA binding site 508765001043 FCD domain; Region: FCD; cl11656 508765001044 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508765001045 Ligand binding site [chemical binding]; other site 508765001046 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508765001047 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 508765001048 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765001049 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508765001050 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765001051 FAD binding domain; Region: FAD_binding_4; pfam01565 508765001052 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 508765001053 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 508765001054 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 508765001055 active site 508765001056 nucleophile elbow; other site 508765001057 transcription termination factor Rho; Provisional; Region: rho; PRK09376 508765001058 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 508765001059 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 508765001060 Substrate binding site; other site 508765001061 Cupin domain; Region: Cupin_2; cl09118 508765001062 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 508765001063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765001064 dimerization interface [polypeptide binding]; other site 508765001065 putative DNA binding site [nucleotide binding]; other site 508765001066 putative Zn2+ binding site [ion binding]; other site 508765001067 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765001068 metal-binding site [ion binding] 508765001069 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508765001070 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765001071 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765001072 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 508765001073 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 508765001074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001075 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 508765001076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 508765001077 substrate binding site [chemical binding]; other site 508765001078 oxyanion hole (OAH) forming residues; other site 508765001079 trimer interface [polypeptide binding]; other site 508765001080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765001081 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765001082 FAD binding site [chemical binding]; other site 508765001083 homotetramer interface [polypeptide binding]; other site 508765001084 substrate binding pocket [chemical binding]; other site 508765001085 catalytic base [active] 508765001086 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508765001087 Ligand binding site [chemical binding]; other site 508765001088 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508765001089 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765001090 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508765001091 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765001092 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 508765001093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001094 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 508765001095 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 508765001096 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 508765001097 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 508765001098 endonuclease III; Region: ENDO3c; smart00478 508765001099 minor groove reading motif; other site 508765001100 helix-hairpin-helix signature motif; other site 508765001101 substrate binding pocket [chemical binding]; other site 508765001102 active site 508765001103 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 508765001104 4Fe-4S binding domain; Region: Fer4; cl02805 508765001105 4Fe-4S binding domain; Region: Fer4; cl02805 508765001106 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765001107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765001108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765001109 active site 508765001110 phosphorylation site [posttranslational modification] 508765001111 intermolecular recognition site; other site 508765001112 dimerization interface [polypeptide binding]; other site 508765001113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765001114 DNA binding site [nucleotide binding] 508765001115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765001116 dimerization interface [polypeptide binding]; other site 508765001117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 508765001118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765001119 dimer interface [polypeptide binding]; other site 508765001120 phosphorylation site [posttranslational modification] 508765001121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765001122 ATP binding site [chemical binding]; other site 508765001123 Mg2+ binding site [ion binding]; other site 508765001124 G-X-G motif; other site 508765001125 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 508765001126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765001127 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508765001128 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 508765001129 oligomerisation interface [polypeptide binding]; other site 508765001130 mobile loop; other site 508765001131 roof hairpin; other site 508765001132 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 508765001133 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 508765001134 ring oligomerisation interface [polypeptide binding]; other site 508765001135 ATP/Mg binding site [chemical binding]; other site 508765001136 stacking interactions; other site 508765001137 hinge regions; other site 508765001138 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 508765001139 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 508765001140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 508765001141 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 508765001142 active site 508765001143 GMP synthase; Reviewed; Region: guaA; PRK00074 508765001144 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 508765001145 AMP/PPi binding site [chemical binding]; other site 508765001146 candidate oxyanion hole; other site 508765001147 catalytic triad [active] 508765001148 potential glutamine specificity residues [chemical binding]; other site 508765001149 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 508765001150 ATP Binding subdomain [chemical binding]; other site 508765001151 Ligand Binding sites [chemical binding]; other site 508765001152 Dimerization subdomain; other site 508765001153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765001154 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 508765001155 putative active site [active] 508765001156 putative metal binding site [ion binding]; other site 508765001157 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508765001158 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508765001159 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 508765001160 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508765001161 Helix-turn-helix domains; Region: HTH; cl00088 508765001162 PRD domain; Region: PRD; cl15445 508765001163 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 508765001164 P-loop; other site 508765001165 active site 508765001166 phosphorylation site [posttranslational modification] 508765001167 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765001168 active site 508765001169 phosphorylation site [posttranslational modification] 508765001170 Glucitol operon activator protein (GutM); Region: GutM; cl01890 508765001171 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 508765001172 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 508765001173 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 508765001174 classical (c) SDRs; Region: SDR_c; cd05233 508765001175 NAD(P) binding site [chemical binding]; other site 508765001176 active site 508765001177 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508765001178 active site 508765001179 intersubunit interactions; other site 508765001180 catalytic residue [active] 508765001181 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 508765001182 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 508765001183 active site 508765001184 dimer interface [polypeptide binding]; other site 508765001185 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 508765001186 dimer interface [polypeptide binding]; other site 508765001187 active site 508765001188 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 508765001189 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 508765001190 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765001191 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765001192 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765001193 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 508765001194 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765001195 catalytic residue [active] 508765001196 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765001197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765001198 RNA binding surface [nucleotide binding]; other site 508765001199 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 508765001200 active site 508765001201 uracil binding [chemical binding]; other site 508765001202 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 508765001203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001204 Family description; Region: UvrD_C_2; cl15862 508765001205 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 508765001206 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 508765001207 nucleotide binding pocket [chemical binding]; other site 508765001208 K-X-D-G motif; other site 508765001209 catalytic site [active] 508765001210 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 508765001211 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 508765001212 Dimer interface [polypeptide binding]; other site 508765001213 BRCT sequence motif; other site 508765001214 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 508765001215 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 508765001216 Amidase; Region: Amidase; cl11426 508765001217 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 508765001218 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 508765001219 GatB domain; Region: GatB_Yqey; cl11497 508765001220 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 508765001221 ribonuclease PH; Reviewed; Region: rph; PRK00173 508765001222 Ribonuclease PH; Region: RNase_PH_bact; cd11362 508765001223 hexamer interface [polypeptide binding]; other site 508765001224 active site 508765001225 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 508765001226 active site 508765001227 dimerization interface [polypeptide binding]; other site 508765001228 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 508765001229 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765001230 active site 508765001231 metal binding site [ion binding]; metal-binding site 508765001232 homotetramer interface [polypeptide binding]; other site 508765001233 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765001234 NodB motif; other site 508765001235 active site 508765001236 catalytic site [active] 508765001237 Zn binding site [ion binding]; other site 508765001238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765001239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765001240 active site 508765001241 phosphorylation site [posttranslational modification] 508765001242 intermolecular recognition site; other site 508765001243 dimerization interface [polypeptide binding]; other site 508765001244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765001245 DNA binding site [nucleotide binding] 508765001246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765001247 dimerization interface [polypeptide binding]; other site 508765001248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765001249 dimer interface [polypeptide binding]; other site 508765001250 phosphorylation site [posttranslational modification] 508765001251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765001252 ATP binding site [chemical binding]; other site 508765001253 Mg2+ binding site [ion binding]; other site 508765001254 G-X-G motif; other site 508765001255 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 508765001256 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 508765001257 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 508765001258 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 508765001259 Sulfatase; Region: Sulfatase; cl10460 508765001260 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 508765001261 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 508765001262 CPxP motif; other site 508765001263 DsrE/DsrF-like family; Region: DrsE; cl00672 508765001264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508765001265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001266 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 508765001267 active site 508765001268 catalytic triad [active] 508765001269 oxyanion hole [active] 508765001270 Endodeoxyribonuclease RusA; Region: RusA; cl01885 508765001271 UGMP family protein; Validated; Region: PRK09604 508765001272 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 508765001273 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765001274 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 508765001275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508765001276 protein binding site [polypeptide binding]; other site 508765001277 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 508765001278 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 508765001279 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765001280 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765001281 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 508765001282 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001283 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765001284 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001285 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765001287 active site 508765001288 ATP binding site [chemical binding]; other site 508765001289 substrate binding site [chemical binding]; other site 508765001290 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 508765001291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765001292 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765001293 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 508765001294 substrate binding site [chemical binding]; other site 508765001295 YabG peptidase U57; Region: Peptidase_U57; cl05250 508765001296 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 508765001297 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765001298 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765001299 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765001300 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 508765001301 putative peptidoglycan binding site; other site 508765001302 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 508765001303 proposed catalytic triad [active] 508765001304 active site nucleophile [active] 508765001305 cyanophycin synthetase; Provisional; Region: PRK14016 508765001306 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765001307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765001308 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765001309 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 508765001310 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 508765001311 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 508765001312 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 508765001313 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 508765001314 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 508765001315 Ligand Binding Site [chemical binding]; other site 508765001316 Domain of unknown function (DUF814); Region: DUF814; pfam05670 508765001317 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 508765001318 CTP synthetase; Validated; Region: pyrG; PRK05380 508765001319 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 508765001320 Catalytic site [active] 508765001321 active site 508765001322 UTP binding site [chemical binding]; other site 508765001323 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 508765001324 active site 508765001325 putative oxyanion hole; other site 508765001326 catalytic triad [active] 508765001327 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 508765001328 transcription termination factor Rho; Provisional; Region: PRK12608 508765001329 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 508765001330 RNA binding site [nucleotide binding]; other site 508765001331 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 508765001332 multimer interface [polypeptide binding]; other site 508765001333 Walker A motif; other site 508765001334 ATP binding site [chemical binding]; other site 508765001335 Walker B motif; other site 508765001336 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 508765001337 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 508765001338 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765001339 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 508765001340 thymidine kinase; Provisional; Region: PRK04296 508765001341 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 508765001342 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 508765001343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765001344 S-adenosylmethionine binding site [chemical binding]; other site 508765001345 peptide chain release factor 1; Validated; Region: prfA; PRK00591 508765001346 RF-1 domain; Region: RF-1; cl02875 508765001347 RF-1 domain; Region: RF-1; cl02875 508765001348 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 508765001349 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 508765001350 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 508765001351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765001352 active site 508765001353 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 508765001354 catalytic motif [active] 508765001355 Zn binding site [ion binding]; other site 508765001356 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 508765001357 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508765001358 active site 508765001359 homodimer interface [polypeptide binding]; other site 508765001360 putative acyltransferase; Provisional; Region: PRK05790 508765001361 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 508765001362 dimer interface [polypeptide binding]; other site 508765001363 active site 508765001364 ATP synthase A chain; Region: ATP-synt_A; cl00413 508765001365 ATP synthase subunit C; Region: ATP-synt_C; cl00466 508765001366 Plant ATP synthase F0; Region: YMF19; cl07975 508765001367 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 508765001368 Plant ATP synthase F0; Region: YMF19; cl07975 508765001369 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 508765001370 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 508765001371 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 508765001372 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 508765001373 beta subunit interaction interface [polypeptide binding]; other site 508765001374 Walker A motif; other site 508765001375 ATP binding site [chemical binding]; other site 508765001376 Walker B motif; other site 508765001377 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765001378 ATP synthase; Region: ATP-synt; cl00365 508765001379 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 508765001380 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 508765001381 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 508765001382 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 508765001383 alpha subunit interaction interface [polypeptide binding]; other site 508765001384 Walker A motif; other site 508765001385 ATP binding site [chemical binding]; other site 508765001386 Walker B motif; other site 508765001387 inhibitor binding site; inhibition site 508765001388 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765001389 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 508765001390 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 508765001391 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 508765001392 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 508765001393 hinge; other site 508765001394 active site 508765001395 stage II sporulation protein D; Region: spore_II_D; TIGR02870 508765001396 Stage II sporulation protein; Region: SpoIID; pfam08486 508765001397 Peptidase family M23; Region: Peptidase_M23; pfam01551 508765001398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765001399 rod shape-determining protein Mbl; Provisional; Region: PRK13928 508765001400 Cell division protein FtsA; Region: FtsA; cl11496 508765001401 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 508765001402 S-adenosylmethionine synthetase; Validated; Region: PRK05250 508765001403 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 508765001404 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 508765001405 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 508765001406 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 508765001407 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 508765001408 DNA binding site [nucleotide binding] 508765001409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001410 Family description; Region: UvrD_C_2; cl15862 508765001411 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 508765001412 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 508765001413 30S subunit binding site; other site 508765001414 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 508765001415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001416 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 508765001417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765001418 nucleotide binding region [chemical binding]; other site 508765001419 ATP-binding site [chemical binding]; other site 508765001420 SEC-C motif; Region: SEC-C; pfam02810 508765001421 peptide chain release factor 2; Provisional; Region: PRK05589 508765001422 RF-1 domain; Region: RF-1; cl02875 508765001423 RF-1 domain; Region: RF-1; cl02875 508765001424 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 508765001425 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 508765001426 metal binding site [ion binding]; metal-binding site 508765001427 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 508765001428 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 508765001429 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 508765001430 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 508765001431 RNA binding site [nucleotide binding]; other site 508765001432 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765001433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001434 EamA-like transporter family; Region: EamA; cl01037 508765001435 EamA-like transporter family; Region: EamA; cl01037 508765001436 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765001437 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 508765001438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765001439 Coenzyme A binding pocket [chemical binding]; other site 508765001440 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 508765001441 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 508765001442 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508765001443 intersubunit interface [polypeptide binding]; other site 508765001444 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765001445 Sensory domain found in PocR; Region: PocR; pfam10114 508765001446 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765001447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765001448 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508765001449 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 508765001450 dimer interface [polypeptide binding]; other site 508765001451 active site 508765001452 metal binding site [ion binding]; metal-binding site 508765001453 dihydroxyacetone kinase; Provisional; Region: PRK14479 508765001454 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 508765001455 DAK2 domain; Region: Dak2; cl03685 508765001456 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 508765001457 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765001458 active site 508765001459 catalytic triad [active] 508765001460 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765001461 active site 508765001462 catalytic triad [active] 508765001463 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 508765001464 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 508765001465 FMN binding site [chemical binding]; other site 508765001466 substrate binding site [chemical binding]; other site 508765001467 putative catalytic residue [active] 508765001468 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765001469 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765001470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765001471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765001472 DNA binding residues [nucleotide binding] 508765001473 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765001474 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 508765001475 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765001476 active site 508765001477 metal binding site [ion binding]; metal-binding site 508765001478 DNA binding site [nucleotide binding] 508765001479 AAA domain; Region: AAA_27; pfam13514 508765001480 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 508765001481 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 508765001482 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 508765001483 metal binding site [ion binding]; metal-binding site 508765001484 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 508765001485 MutS-like homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess...; Region: ABC_MutS-like; cd03283 508765001486 Walker A/P-loop; other site 508765001487 ATP binding site [chemical binding]; other site 508765001488 Q-loop/lid; other site 508765001489 ABC transporter signature motif; other site 508765001490 Walker B; other site 508765001491 D-loop; other site 508765001492 H-loop/switch region; other site 508765001493 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 508765001494 active site 508765001495 substrate binding site [chemical binding]; other site 508765001496 catalytic site [active] 508765001497 FOG: CBS domain [General function prediction only]; Region: COG0517 508765001498 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 508765001499 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 508765001500 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 508765001501 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 508765001502 RNA binding site [nucleotide binding]; other site 508765001503 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 508765001504 RNA binding site [nucleotide binding]; other site 508765001505 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508765001506 RNA binding site [nucleotide binding]; other site 508765001507 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 508765001508 RNA binding site [nucleotide binding]; other site 508765001509 domain interface; other site 508765001510 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 508765001511 pyruvate kinase; Provisional; Region: PRK05826 508765001512 domain interfaces; other site 508765001513 active site 508765001514 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 508765001515 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 508765001516 metal binding site [ion binding]; metal-binding site 508765001517 dimer interface [polypeptide binding]; other site 508765001518 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765001519 Sporulation related domain; Region: SPOR; cl10051 508765001520 Maf-like protein; Region: Maf; pfam02545 508765001521 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 508765001522 active site 508765001523 dimer interface [polypeptide binding]; other site 508765001524 hypothetical protein; Reviewed; Region: PRK00024 508765001525 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 508765001526 MPN+ (JAMM) motif; other site 508765001527 Zinc-binding site [ion binding]; other site 508765001528 rod shape-determining protein MreB; Provisional; Region: PRK13927 508765001529 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 508765001530 ATP binding site [chemical binding]; other site 508765001531 Cell division protein FtsA; Region: FtsA; cl11496 508765001532 rod shape-determining protein MreC; Provisional; Region: PRK13922 508765001533 rod shape-determining protein MreC; Region: MreC; pfam04085 508765001534 rod shape-determining protein MreD; Region: MreD; cl01087 508765001535 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 508765001536 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765001537 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 508765001538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765001539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765001540 septum formation inhibitor; Reviewed; Region: minC; PRK00513 508765001541 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 508765001542 septum site-determining protein MinD; Region: minD_bact; TIGR01968 508765001543 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 508765001544 Switch I; other site 508765001545 Switch II; other site 508765001546 Septum formation topological specificity factor MinE; Region: MinE; cl00538 508765001547 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508765001548 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 508765001549 active site 508765001550 dimer interfaces [polypeptide binding]; other site 508765001551 catalytic residues [active] 508765001552 Peptidase family M23; Region: Peptidase_M23; pfam01551 508765001553 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 508765001554 active site 508765001555 putative substrate binding region [chemical binding]; other site 508765001556 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 508765001557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765001558 FeS/SAM binding site; other site 508765001559 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 508765001560 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 508765001561 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 508765001562 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 508765001563 homodimer interface [polypeptide binding]; other site 508765001564 oligonucleotide binding site [chemical binding]; other site 508765001565 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 508765001566 Protein of unknown function (DUF464); Region: DUF464; cl01080 508765001567 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 508765001568 GTPase CgtA; Reviewed; Region: obgE; PRK12297 508765001569 GTP1/OBG; Region: GTP1_OBG; pfam01018 508765001570 Obg GTPase; Region: Obg; cd01898 508765001571 G1 box; other site 508765001572 GTP/Mg2+ binding site [chemical binding]; other site 508765001573 Switch I region; other site 508765001574 G2 box; other site 508765001575 G3 box; other site 508765001576 Switch II region; other site 508765001577 G4 box; other site 508765001578 G5 box; other site 508765001579 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 508765001580 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 508765001581 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 508765001582 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 508765001583 active site 508765001584 (T/H)XGH motif; other site 508765001585 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 508765001586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765001587 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 508765001588 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 508765001589 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508765001590 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 508765001591 active site 508765001592 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508765001593 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765001594 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 508765001595 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 508765001596 SLBB domain; Region: SLBB; pfam10531 508765001597 comEA protein; Region: comE; TIGR01259 508765001598 TRAM domain; Region: TRAM; cl01282 508765001599 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 508765001600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765001601 S-adenosylmethionine binding site [chemical binding]; other site 508765001602 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 508765001603 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765001604 Int/Topo IB signature motif; other site 508765001605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765001606 non-specific DNA binding site [nucleotide binding]; other site 508765001607 salt bridge; other site 508765001608 sequence-specific DNA binding site [nucleotide binding]; other site 508765001609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765001610 non-specific DNA binding site [nucleotide binding]; other site 508765001611 salt bridge; other site 508765001612 sequence-specific DNA binding site [nucleotide binding]; other site 508765001613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765001614 non-specific DNA binding site [nucleotide binding]; other site 508765001615 salt bridge; other site 508765001616 sequence-specific DNA binding site [nucleotide binding]; other site 508765001617 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765001618 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 508765001619 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765001620 YvrJ protein family; Region: YvrJ; pfam12841 508765001621 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 508765001622 putative active site [active] 508765001623 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 508765001624 putative active site [active] 508765001625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765001626 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 508765001627 cofactor binding site; other site 508765001628 DNA binding site [nucleotide binding] 508765001629 substrate interaction site [chemical binding]; other site 508765001630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765001631 DNA binding site [nucleotide binding] 508765001632 substrate interaction site [chemical binding]; other site 508765001633 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 508765001634 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765001635 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765001636 active site 508765001637 metal binding site [ion binding]; metal-binding site 508765001638 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 508765001639 putative peptidoglycan binding site; other site 508765001640 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765001641 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 508765001642 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 508765001643 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 508765001644 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 508765001645 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765001646 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765001647 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765001648 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765001649 metal binding site [ion binding]; metal-binding site 508765001650 active site 508765001651 I-site; other site 508765001652 Glyco_18 domain; Region: Glyco_18; smart00636 508765001653 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 508765001654 active site 508765001655 Chitinase C; Region: ChiC; pfam06483 508765001656 GAF domain; Region: GAF; cl15785 508765001657 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 508765001658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765001659 Walker A motif; other site 508765001660 ATP binding site [chemical binding]; other site 508765001661 Walker B motif; other site 508765001662 arginine finger; other site 508765001663 Helix-turn-helix domains; Region: HTH; cl00088 508765001664 peptidase; Reviewed; Region: PRK13004 508765001665 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 508765001666 putative metal binding site [ion binding]; other site 508765001667 putative dimer interface [polypeptide binding]; other site 508765001668 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 508765001669 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508765001670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001671 carbamate kinase; Reviewed; Region: PRK12686 508765001672 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 508765001673 putative substrate binding site [chemical binding]; other site 508765001674 nucleotide binding site [chemical binding]; other site 508765001675 nucleotide binding site [chemical binding]; other site 508765001676 homodimer interface [polypeptide binding]; other site 508765001677 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 508765001678 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 508765001679 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765001680 catalytic residue [active] 508765001681 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 508765001682 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508765001683 active site 508765001684 putative substrate binding pocket [chemical binding]; other site 508765001685 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765001686 Predicted membrane protein [Function unknown]; Region: COG2364 508765001687 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 508765001688 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508765001689 active site 508765001690 putative substrate binding pocket [chemical binding]; other site 508765001691 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 508765001692 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 508765001693 active site 508765001694 FMN binding site [chemical binding]; other site 508765001695 substrate binding site [chemical binding]; other site 508765001696 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 508765001697 4Fe-4S binding domain; Region: Fer4; cl02805 508765001698 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 508765001699 homotrimer interaction site [polypeptide binding]; other site 508765001700 putative active site [active] 508765001701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001702 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 508765001703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 508765001704 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 508765001705 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765001706 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 508765001707 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765001708 phenylhydantoinase; Validated; Region: PRK08323 508765001709 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 508765001710 tetramer interface [polypeptide binding]; other site 508765001711 active site 508765001712 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 508765001713 nucleoside/Zn binding site; other site 508765001714 dimer interface [polypeptide binding]; other site 508765001715 catalytic motif [active] 508765001716 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 508765001717 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 508765001718 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765001719 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 508765001720 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 508765001721 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 508765001722 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 508765001723 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765001724 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 508765001725 xanthine permease; Region: pbuX; TIGR03173 508765001726 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 508765001727 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508765001728 intersubunit interface [polypeptide binding]; other site 508765001729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765001730 ABC-ATPase subunit interface; other site 508765001731 dimer interface [polypeptide binding]; other site 508765001732 putative PBP binding regions; other site 508765001733 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508765001734 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765001735 Walker A/P-loop; other site 508765001736 ATP binding site [chemical binding]; other site 508765001737 Q-loop/lid; other site 508765001738 ABC transporter signature motif; other site 508765001739 Walker B; other site 508765001740 D-loop; other site 508765001741 H-loop/switch region; other site 508765001742 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 508765001743 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 508765001744 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 508765001745 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 508765001746 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 508765001747 CPxP motif; other site 508765001748 DsrE/DsrF-like family; Region: DrsE; cl00672 508765001749 selenophosphate synthetase; Provisional; Region: PRK00943 508765001750 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 508765001751 dimerization interface [polypeptide binding]; other site 508765001752 putative ATP binding site [chemical binding]; other site 508765001753 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765001754 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508765001755 Ligand binding site; other site 508765001756 metal-binding site 508765001757 XdhC Rossmann domain; Region: XdhC_C; pfam13478 508765001758 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 508765001759 Cobalt transport protein; Region: CbiQ; cl00463 508765001760 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 508765001761 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 508765001762 Walker A/P-loop; other site 508765001763 ATP binding site [chemical binding]; other site 508765001764 Q-loop/lid; other site 508765001765 ABC transporter signature motif; other site 508765001766 Walker B; other site 508765001767 D-loop; other site 508765001768 H-loop/switch region; other site 508765001769 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 508765001770 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765001771 Cobalt transport protein component CbiN; Region: CbiN; cl00842 508765001772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765001773 Helix-turn-helix domains; Region: HTH; cl00088 508765001774 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 508765001775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001776 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 508765001777 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 508765001778 FAD binding pocket [chemical binding]; other site 508765001779 FAD binding motif [chemical binding]; other site 508765001780 phosphate binding motif [ion binding]; other site 508765001781 beta-alpha-beta structure motif; other site 508765001782 NAD binding pocket [chemical binding]; other site 508765001783 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 508765001784 catalytic loop [active] 508765001785 iron binding site [ion binding]; other site 508765001786 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 508765001787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 508765001788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765001789 Walker A motif; other site 508765001790 ATP binding site [chemical binding]; other site 508765001791 Walker B motif; other site 508765001792 arginine finger; other site 508765001793 Helix-turn-helix domains; Region: HTH; cl00088 508765001794 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508765001795 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 508765001796 putative NAD(P) binding site [chemical binding]; other site 508765001797 catalytic Zn binding site [ion binding]; other site 508765001798 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508765001799 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508765001800 FAD binding pocket [chemical binding]; other site 508765001801 FAD binding motif [chemical binding]; other site 508765001802 phosphate binding motif [ion binding]; other site 508765001803 beta-alpha-beta structure motif; other site 508765001804 NAD binding pocket [chemical binding]; other site 508765001805 Iron coordination center [ion binding]; other site 508765001806 putative oxidoreductase; Provisional; Region: PRK12831 508765001807 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765001808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001810 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765001811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765001812 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765001813 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765001814 dimer interface [polypeptide binding]; other site 508765001815 putative CheW interface [polypeptide binding]; other site 508765001816 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 508765001817 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 508765001818 active site 508765001819 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 508765001820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765001821 short chain dehydrogenase; Provisional; Region: PRK06701 508765001822 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 508765001823 NAD binding site [chemical binding]; other site 508765001824 metal binding site [ion binding]; metal-binding site 508765001825 active site 508765001826 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765001827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765001828 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765001829 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 508765001830 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 508765001831 active site 508765001832 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 508765001833 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 508765001834 homotrimer interaction site [polypeptide binding]; other site 508765001835 putative active site [active] 508765001836 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 508765001837 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765001838 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 508765001839 Walker A/P-loop; other site 508765001840 ATP binding site [chemical binding]; other site 508765001841 Q-loop/lid; other site 508765001842 ABC transporter signature motif; other site 508765001843 Walker B; other site 508765001844 D-loop; other site 508765001845 H-loop/switch region; other site 508765001846 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765001847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765001848 DNA-binding site [nucleotide binding]; DNA binding site 508765001849 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 508765001850 4Fe-4S binding domain; Region: Fer4; cl02805 508765001851 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 508765001852 DltD central region; Region: DltD_M; pfam04918 508765001853 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 508765001854 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 508765001855 AMP-binding enzyme; Region: AMP-binding; cl15778 508765001856 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 508765001857 Phosphopantetheine attachment site; Region: PP-binding; cl09936 508765001858 Cupin domain; Region: Cupin_2; cl09118 508765001859 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 508765001860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765001861 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 508765001862 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765001863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001864 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765001865 putative substrate translocation pore; other site 508765001866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001867 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765001868 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765001869 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765001870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001871 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508765001872 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765001873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765001874 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765001875 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765001876 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765001877 ligand binding site [chemical binding]; other site 508765001878 flexible hinge region; other site 508765001879 Helix-turn-helix domains; Region: HTH; cl00088 508765001880 putative switch regulator; other site 508765001881 non-specific DNA interactions [nucleotide binding]; other site 508765001882 DNA binding site [nucleotide binding] 508765001883 sequence specific DNA binding site [nucleotide binding]; other site 508765001884 putative cAMP binding site [chemical binding]; other site 508765001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765001886 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765001887 putative substrate translocation pore; other site 508765001888 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765001889 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 508765001890 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 508765001891 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765001892 catalytic residue [active] 508765001893 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 508765001894 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765001895 Zn2+ binding site [ion binding]; other site 508765001896 Mg2+ binding site [ion binding]; other site 508765001897 endonuclease IV; Provisional; Region: PRK01060 508765001898 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 508765001899 AP (apurinic/apyrimidinic) site pocket; other site 508765001900 DNA interaction; other site 508765001901 Metal-binding active site; metal-binding site 508765001902 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 508765001903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765001904 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765001905 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765001906 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 508765001907 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765001908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765001909 DNA-binding site [nucleotide binding]; DNA binding site 508765001910 UTRA domain; Region: UTRA; cl01230 508765001911 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 508765001912 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 508765001913 active site 508765001914 dimer interface [polypeptide binding]; other site 508765001915 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 508765001916 active site 508765001917 trimer interface [polypeptide binding]; other site 508765001918 allosteric site; other site 508765001919 active site lid [active] 508765001920 hexamer (dimer of trimers) interface [polypeptide binding]; other site 508765001921 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 508765001922 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765001923 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765001924 active site turn [active] 508765001925 phosphorylation site [posttranslational modification] 508765001926 CutC family; Region: CutC; cl01218 508765001927 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765001928 biotin synthase; Region: bioB; TIGR00433 508765001929 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765001930 FeS/SAM binding site; other site 508765001931 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 508765001932 AAA domain; Region: AAA_26; pfam13500 508765001933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001934 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001935 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765001936 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 508765001937 DNA binding residues [nucleotide binding] 508765001938 dimer interface [polypeptide binding]; other site 508765001939 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765001940 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765001941 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 508765001942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765001943 Walker A/P-loop; other site 508765001944 ATP binding site [chemical binding]; other site 508765001945 Q-loop/lid; other site 508765001946 ABC transporter signature motif; other site 508765001947 Walker B; other site 508765001948 D-loop; other site 508765001949 H-loop/switch region; other site 508765001950 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 508765001951 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765001952 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 508765001953 Walker A/P-loop; other site 508765001954 ATP binding site [chemical binding]; other site 508765001955 Q-loop/lid; other site 508765001956 ABC transporter signature motif; other site 508765001957 Walker B; other site 508765001958 D-loop; other site 508765001959 H-loop/switch region; other site 508765001960 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 508765001961 putative valine binding site [chemical binding]; other site 508765001962 dimer interface [polypeptide binding]; other site 508765001963 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 508765001964 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765001965 PYR/PP interface [polypeptide binding]; other site 508765001966 dimer interface [polypeptide binding]; other site 508765001967 TPP binding site [chemical binding]; other site 508765001968 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 508765001969 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 508765001970 TPP-binding site [chemical binding]; other site 508765001971 dimer interface [polypeptide binding]; other site 508765001972 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508765001973 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765001974 Predicted membrane protein [Function unknown]; Region: COG1289 508765001975 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 508765001976 T-box leader 508765001977 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 508765001978 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765001979 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765001980 ligand binding site [chemical binding]; other site 508765001981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765001982 Helix-turn-helix domains; Region: HTH; cl00088 508765001983 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765001984 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 508765001985 intersubunit interface [polypeptide binding]; other site 508765001986 active site 508765001987 catalytic residue [active] 508765001988 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 508765001989 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 508765001990 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 508765001991 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 508765001992 hybrid cluster protein; Provisional; Region: PRK05290 508765001993 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765001994 ACS interaction site; other site 508765001995 CODH interaction site; other site 508765001996 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 508765001997 hybrid metal cluster; other site 508765001998 Predicted membrane protein [Function unknown]; Region: COG2364 508765001999 Accessory gene regulator B; Region: AgrB; cl01873 508765002000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 508765002001 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 508765002002 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 508765002003 Walker A/P-loop; other site 508765002004 ATP binding site [chemical binding]; other site 508765002005 Q-loop/lid; other site 508765002006 ABC transporter signature motif; other site 508765002007 Walker B; other site 508765002008 D-loop; other site 508765002009 H-loop/switch region; other site 508765002010 NIL domain; Region: NIL; cl09633 508765002011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002012 dimer interface [polypeptide binding]; other site 508765002013 conserved gate region; other site 508765002014 ABC-ATPase subunit interface; other site 508765002015 NMT1-like family; Region: NMT1_2; cl15260 508765002016 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 508765002017 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 508765002018 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 508765002019 RNA/DNA hybrid binding site [nucleotide binding]; other site 508765002020 active site 508765002021 YtxH-like protein; Region: YtxH; cl02079 508765002022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765002023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765002026 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002027 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765002028 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765002029 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 508765002030 Clp amino terminal domain; Region: Clp_N; pfam02861 508765002031 Clp amino terminal domain; Region: Clp_N; pfam02861 508765002032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765002033 Walker A motif; other site 508765002034 ATP binding site [chemical binding]; other site 508765002035 Walker B motif; other site 508765002036 arginine finger; other site 508765002037 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 508765002038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765002039 Walker A motif; other site 508765002040 ATP binding site [chemical binding]; other site 508765002041 Walker B motif; other site 508765002042 arginine finger; other site 508765002043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 508765002044 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765002045 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 508765002046 putative active site pocket [active] 508765002047 cleavage site 508765002048 Predicted membrane protein [Function unknown]; Region: COG4684 508765002049 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765002050 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 508765002051 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 508765002052 Ligand Binding Site [chemical binding]; other site 508765002053 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 508765002054 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765002055 metal binding site [ion binding]; metal-binding site 508765002056 active site 508765002057 I-site; other site 508765002058 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765002059 T-box leader 508765002060 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765002061 NodB motif; other site 508765002062 active site 508765002063 catalytic site [active] 508765002064 Zn binding site [ion binding]; other site 508765002065 Predicted ATPase [General function prediction only]; Region: COG3899 508765002066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765002067 metal binding site [ion binding]; metal-binding site 508765002068 active site 508765002069 I-site; other site 508765002070 GAF domain; Region: GAF; cl15785 508765002071 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 508765002072 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 508765002073 trimer interface [polypeptide binding]; other site 508765002074 active site 508765002075 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765002076 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765002077 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765002078 ABC transporter; Region: ABC_tran_2; pfam12848 508765002079 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765002080 Helix-turn-helix domains; Region: HTH; cl00088 508765002081 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 508765002082 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 508765002083 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508765002084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765002085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765002086 catalytic residue [active] 508765002087 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 508765002088 active site 508765002089 ADP/pyrophosphate binding site [chemical binding]; other site 508765002090 dimerization interface [polypeptide binding]; other site 508765002091 allosteric effector site; other site 508765002092 fructose-1,6-bisphosphate binding site; other site 508765002093 ferric uptake regulator; Provisional; Region: fur; PRK09462 508765002094 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508765002095 metal binding site 2 [ion binding]; metal-binding site 508765002096 putative DNA binding helix; other site 508765002097 metal binding site 1 [ion binding]; metal-binding site 508765002098 dimer interface [polypeptide binding]; other site 508765002099 structural Zn2+ binding site [ion binding]; other site 508765002100 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765002101 ABC-ATPase subunit interface; other site 508765002102 dimer interface [polypeptide binding]; other site 508765002103 putative PBP binding regions; other site 508765002104 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 508765002105 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 508765002106 oligoendopeptidase F; Region: pepF; TIGR00181 508765002107 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 508765002108 active site 508765002109 Zn binding site [ion binding]; other site 508765002110 Rhomboid family; Region: Rhomboid; cl11446 508765002111 glutamate dehydrogenase; Provisional; Region: PRK09414 508765002112 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 508765002113 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 508765002114 NAD(P) binding site [chemical binding]; other site 508765002115 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 508765002116 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 508765002117 DXD motif; other site 508765002118 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 508765002119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002120 ATP binding site [chemical binding]; other site 508765002121 Mg2+ binding site [ion binding]; other site 508765002122 G-X-G motif; other site 508765002123 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 508765002124 anchoring element; other site 508765002125 dimer interface [polypeptide binding]; other site 508765002126 ATP binding site [chemical binding]; other site 508765002127 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 508765002128 active site 508765002129 metal binding site [ion binding]; metal-binding site 508765002130 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 508765002131 DNA topoisomerase IV subunit A; Provisional; Region: PRK13979 508765002132 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 508765002133 CAP-like domain; other site 508765002134 active site 508765002135 primary dimer interface [polypeptide binding]; other site 508765002136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 508765002137 DJ-1 family protein; Region: not_thiJ; TIGR01383 508765002138 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 508765002139 conserved cys residue [active] 508765002140 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 508765002141 DHH family; Region: DHH; pfam01368 508765002142 DHHA1 domain; Region: DHHA1; pfam02272 508765002143 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 508765002144 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 508765002145 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765002146 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765002147 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 508765002148 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 508765002149 active site 508765002150 homodimer interface [polypeptide binding]; other site 508765002151 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765002152 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 508765002153 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 508765002154 dimer interface [polypeptide binding]; other site 508765002155 PYR/PP interface [polypeptide binding]; other site 508765002156 TPP binding site [chemical binding]; other site 508765002157 substrate binding site [chemical binding]; other site 508765002158 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 508765002159 Domain of unknown function; Region: EKR; cl11037 508765002160 4Fe-4S binding domain; Region: Fer4; cl02805 508765002161 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765002162 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 508765002163 TPP-binding site [chemical binding]; other site 508765002164 dimer interface [polypeptide binding]; other site 508765002165 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 508765002166 aspartate aminotransferase; Provisional; Region: PRK05764 508765002167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765002168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002169 homodimer interface [polypeptide binding]; other site 508765002170 catalytic residue [active] 508765002171 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765002172 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 508765002173 homodimer interface [polypeptide binding]; other site 508765002174 substrate-cofactor binding pocket; other site 508765002175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002176 catalytic residue [active] 508765002177 Protein of unknown function (DUF342); Region: DUF342; pfam03961 508765002178 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 508765002179 CheD chemotactic sensory transduction; Region: CheD; cl00810 508765002180 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 508765002181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765002182 active site 508765002183 phosphorylation site [posttranslational modification] 508765002184 intermolecular recognition site; other site 508765002185 dimerization interface [polypeptide binding]; other site 508765002186 CheB methylesterase; Region: CheB_methylest; pfam01339 508765002187 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 508765002188 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 508765002189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002190 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 508765002191 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 508765002192 putative binding surface; other site 508765002193 active site 508765002194 P2 response regulator binding domain; Region: P2; pfam07194 508765002195 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 508765002196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002197 ATP binding site [chemical binding]; other site 508765002198 Mg2+ binding site [ion binding]; other site 508765002199 G-X-G motif; other site 508765002200 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 508765002201 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 508765002202 Chemotaxis phosphatase CheX; Region: CheX; cl15816 508765002203 Chemotaxis phosphatase CheX; Region: CheX; cl15816 508765002204 Response regulator receiver domain; Region: Response_reg; pfam00072 508765002205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765002206 active site 508765002207 phosphorylation site [posttranslational modification] 508765002208 intermolecular recognition site; other site 508765002209 dimerization interface [polypeptide binding]; other site 508765002210 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 508765002211 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 508765002212 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 508765002213 flagellar motor switch protein; Validated; Region: PRK08119 508765002214 Chemotaxis phosphatase CheX; Region: CheX; cl15816 508765002215 Chemotaxis phosphatase CheX; Region: CheX; cl15816 508765002216 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 508765002217 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 508765002218 FlgN protein; Region: FlgN; cl09176 508765002219 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 508765002220 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 508765002221 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 508765002222 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 508765002223 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002224 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002225 FliW protein; Region: FliW; cl00740 508765002226 Global regulator protein family; Region: CsrA; cl00670 508765002227 FlaG protein; Region: FlaG; cl00591 508765002228 Flagellar protein FliS; Region: FliS; cl00654 508765002229 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 508765002230 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 508765002231 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 508765002232 Putative motility protein; Region: YjfB_motility; pfam14070 508765002233 flagellin; Provisional; Region: PRK12804 508765002234 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002235 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002236 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 508765002237 putative metal binding site; other site 508765002238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765002239 binding surface 508765002240 TPR motif; other site 508765002241 TPR repeat; Region: TPR_11; pfam13414 508765002242 flagellin; Provisional; Region: PRK12804 508765002243 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002244 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508765002246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508765002247 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 508765002248 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765002249 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 508765002250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002251 motif II; other site 508765002252 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 508765002253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002254 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 508765002255 ligand binding site; other site 508765002256 Sulfatase; Region: Sulfatase; cl10460 508765002257 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 508765002258 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765002259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765002260 catalytic residue [active] 508765002261 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508765002262 active site 508765002263 metal-binding site 508765002264 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 508765002265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765002266 pseudaminic acid synthase; Region: PseI; TIGR03586 508765002267 NeuB family; Region: NeuB; cl00496 508765002268 SAF domain; Region: SAF; cl00555 508765002269 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 508765002270 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 508765002271 NAD(P) binding site [chemical binding]; other site 508765002272 homodimer interface [polypeptide binding]; other site 508765002273 substrate binding site [chemical binding]; other site 508765002274 active site 508765002275 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 508765002276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002277 NAD(P) binding site [chemical binding]; other site 508765002278 active site 508765002279 flagellin; Provisional; Region: PRK12804 508765002280 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765002281 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765002282 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 508765002283 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 508765002284 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12630 508765002285 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 508765002286 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 508765002287 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 508765002288 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 508765002289 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 508765002290 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 508765002291 FliG C-terminal domain; Region: FliG_C; pfam01706 508765002292 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 508765002293 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 508765002294 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 508765002295 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 508765002296 Walker A motif/ATP binding site; other site 508765002297 Walker B motif; other site 508765002298 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 508765002299 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 508765002300 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 508765002301 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12812 508765002302 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 508765002303 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 508765002304 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 508765002305 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 508765002306 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 508765002307 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 508765002308 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 508765002309 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 508765002310 Flagellar protein (FlbD); Region: FlbD; cl00683 508765002311 flagellar motor protein MotP; Reviewed; Region: PRK06926 508765002312 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 508765002313 flagellar motor protein MotS; Reviewed; Region: PRK06925 508765002314 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 508765002315 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 508765002316 ligand binding site [chemical binding]; other site 508765002317 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 508765002318 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 508765002319 FliP family; Region: FliP; cl00593 508765002320 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 508765002321 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 508765002322 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 508765002323 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 508765002324 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 508765002325 FHIPEP family; Region: FHIPEP; pfam00771 508765002326 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 508765002327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765002328 GTP/Mg2+ binding site [chemical binding]; other site 508765002329 G5 box; other site 508765002330 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765002331 G1 box; other site 508765002332 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 508765002333 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 508765002334 P-loop; other site 508765002335 Flagellar protein YcgR; Region: YcgR_2; pfam12945 508765002336 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 508765002337 PilZ domain; Region: PilZ; cl01260 508765002338 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 508765002339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765002340 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765002341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765002342 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 508765002343 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 508765002344 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 508765002345 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 508765002346 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 508765002347 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 508765002348 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508765002349 DRTGG domain; Region: DRTGG; cl12147 508765002350 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508765002351 DHHA2 domain; Region: DHHA2; pfam02833 508765002352 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 508765002353 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765002354 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765002355 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765002356 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765002357 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765002358 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 508765002359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002360 DNA binding residues [nucleotide binding] 508765002361 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508765002362 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 508765002363 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 508765002364 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 508765002365 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 508765002366 anti sigma factor interaction site; other site 508765002367 regulatory phosphorylation site [posttranslational modification]; other site 508765002368 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 508765002369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002370 ATP binding site [chemical binding]; other site 508765002371 Mg2+ binding site [ion binding]; other site 508765002372 G-X-G motif; other site 508765002373 sporulation sigma factor SigF; Validated; Region: PRK05572 508765002374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765002375 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765002376 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002377 DNA binding residues [nucleotide binding] 508765002378 SpoVA protein; Region: SpoVA; cl04298 508765002379 stage V sporulation protein AD; Validated; Region: PRK08304 508765002380 stage V sporulation protein AD; Provisional; Region: PRK12404 508765002381 SpoVA protein; Region: SpoVA; cl04298 508765002382 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 508765002383 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765002384 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 508765002385 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765002386 Competence protein; Region: Competence; cl00471 508765002387 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 508765002388 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 508765002389 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 508765002390 Germination protease; Region: Peptidase_A25; cl04057 508765002391 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 508765002392 stage II sporulation protein P; Region: spore_II_P; TIGR02867 508765002393 GTP-binding protein LepA; Provisional; Region: PRK05433 508765002394 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 508765002395 G1 box; other site 508765002396 putative GEF interaction site [polypeptide binding]; other site 508765002397 GTP/Mg2+ binding site [chemical binding]; other site 508765002398 Switch I region; other site 508765002399 G2 box; other site 508765002400 G3 box; other site 508765002401 Switch II region; other site 508765002402 G4 box; other site 508765002403 G5 box; other site 508765002404 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 508765002405 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 508765002406 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 508765002407 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 508765002408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002409 FeS/SAM binding site; other site 508765002410 HemN C-terminal domain; Region: HemN_C; pfam06969 508765002411 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 508765002412 Helix-turn-helix domains; Region: HTH; cl00088 508765002413 HrcA protein C terminal domain; Region: HrcA; pfam01628 508765002414 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 508765002415 dimer interface [polypeptide binding]; other site 508765002416 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 508765002417 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 508765002418 StbA protein; Region: StbA; pfam06406 508765002419 chaperone protein DnaJ; Provisional; Region: PRK14297 508765002420 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508765002421 HSP70 interaction site [polypeptide binding]; other site 508765002422 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 508765002423 substrate binding site [polypeptide binding]; other site 508765002424 dimer interface [polypeptide binding]; other site 508765002425 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 508765002426 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765002428 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 508765002429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765002430 S-adenosylmethionine binding site [chemical binding]; other site 508765002431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 508765002432 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 508765002433 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 508765002434 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508765002435 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 508765002436 nucleotide binding site/active site [active] 508765002437 HIT family signature motif; other site 508765002438 catalytic residue [active] 508765002439 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 508765002440 GatB domain; Region: GatB_Yqey; cl11497 508765002441 YabP family; Region: YabP; cl06766 508765002442 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 508765002443 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 508765002444 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 508765002445 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 508765002446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765002447 Zn2+ binding site [ion binding]; other site 508765002448 Mg2+ binding site [ion binding]; other site 508765002449 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 508765002450 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 508765002451 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 508765002452 active site 508765002453 GTPase Era; Reviewed; Region: era; PRK00089 508765002454 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 508765002455 G1 box; other site 508765002456 GTP/Mg2+ binding site [chemical binding]; other site 508765002457 Switch I region; other site 508765002458 G2 box; other site 508765002459 Switch II region; other site 508765002460 G3 box; other site 508765002461 G4 box; other site 508765002462 G5 box; other site 508765002463 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 508765002464 Recombination protein O N terminal; Region: RecO_N; cl15812 508765002465 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 508765002466 Recombination protein O C terminal; Region: RecO_C; pfam02565 508765002467 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 508765002468 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 508765002469 Helix-turn-helix domains; Region: HTH; cl00088 508765002470 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 508765002471 FOG: CBS domain [General function prediction only]; Region: COG0517 508765002472 pyruvate phosphate dikinase; Provisional; Region: PRK09279 508765002473 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 508765002474 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 508765002475 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 508765002476 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 508765002477 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765002478 active site 508765002479 ATP binding site [chemical binding]; other site 508765002480 substrate binding site [chemical binding]; other site 508765002481 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 508765002482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765002483 Zn2+ binding site [ion binding]; other site 508765002484 Mg2+ binding site [ion binding]; other site 508765002485 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 508765002486 DNA primase; Validated; Region: dnaG; PRK05667 508765002487 CHC2 zinc finger; Region: zf-CHC2; cl15369 508765002488 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 508765002489 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 508765002490 active site 508765002491 metal binding site [ion binding]; metal-binding site 508765002492 interdomain interaction site; other site 508765002493 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 508765002494 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508765002495 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 508765002496 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 508765002497 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 508765002498 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765002499 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765002500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765002501 DNA binding residues [nucleotide binding] 508765002502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002503 Uncharacterized conserved protein [Function unknown]; Region: COG0327 508765002504 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 508765002505 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 508765002506 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765002507 Int/Topo IB signature motif; other site 508765002508 Domain of unknown function (DUF955); Region: DUF955; cl01076 508765002509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002510 non-specific DNA binding site [nucleotide binding]; other site 508765002511 salt bridge; other site 508765002512 sequence-specific DNA binding site [nucleotide binding]; other site 508765002513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765002514 ORF6N domain; Region: ORF6N; pfam10543 508765002515 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765002516 AntA/AntB antirepressor; Region: AntA; cl01430 508765002517 ORF6C domain; Region: ORF6C; pfam10552 508765002518 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508765002519 replicative DNA helicase; Region: DnaB; TIGR00665 508765002520 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 508765002521 Walker A motif; other site 508765002522 ATP binding site [chemical binding]; other site 508765002523 Walker B motif; other site 508765002524 DNA binding loops [nucleotide binding] 508765002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765002526 cofactor binding site; other site 508765002527 DNA binding site [nucleotide binding] 508765002528 substrate interaction site [chemical binding]; other site 508765002529 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765002530 DNA binding site [nucleotide binding] 508765002531 Int/Topo IB signature motif; other site 508765002532 active site 508765002533 Helix-turn-helix domains; Region: HTH; cl00088 508765002534 Phage terminase, small subunit; Region: Terminase_4; cl01525 508765002535 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 508765002536 Phage Terminase; Region: Terminase_1; pfam03354 508765002537 Phage-related protein [Function unknown]; Region: COG4695; cl01923 508765002538 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 508765002539 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 508765002540 Phage capsid family; Region: Phage_capsid; pfam05065 508765002541 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 508765002542 oligomerization interface [polypeptide binding]; other site 508765002543 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 508765002544 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 508765002545 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 508765002546 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 508765002547 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 508765002548 Phage-related protein [Function unknown]; Region: COG5412 508765002549 Phage-related protein [Function unknown]; Region: COG4722; cl15832 508765002550 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 508765002551 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 508765002552 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 508765002553 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508765002554 active site 508765002555 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508765002556 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765002557 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 508765002558 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 508765002559 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 508765002560 Walker A/P-loop; other site 508765002561 ATP binding site [chemical binding]; other site 508765002562 Q-loop/lid; other site 508765002563 ABC transporter signature motif; other site 508765002564 Walker B; other site 508765002565 D-loop; other site 508765002566 H-loop/switch region; other site 508765002567 TOBE domain; Region: TOBE_2; cl01440 508765002568 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 508765002569 Helix-turn-helix domains; Region: HTH; cl00088 508765002570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765002571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765002572 DNA binding site [nucleotide binding] 508765002573 domain linker motif; other site 508765002574 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765002575 dimerization interface [polypeptide binding]; other site 508765002576 ligand binding site [chemical binding]; other site 508765002577 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 508765002578 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 508765002579 homodimer interface [polypeptide binding]; other site 508765002580 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 508765002581 active site pocket [active] 508765002582 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 508765002583 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 508765002584 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765002585 K+-transporting ATPase, c chain; Region: KdpC; cl00944 508765002586 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 508765002587 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 508765002588 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 508765002589 Ligand Binding Site [chemical binding]; other site 508765002590 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 508765002591 GAF domain; Region: GAF; cl15785 508765002592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765002593 dimer interface [polypeptide binding]; other site 508765002594 phosphorylation site [posttranslational modification] 508765002595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002596 ATP binding site [chemical binding]; other site 508765002597 G-X-G motif; other site 508765002598 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 508765002599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765002600 active site 508765002601 phosphorylation site [posttranslational modification] 508765002602 intermolecular recognition site; other site 508765002603 dimerization interface [polypeptide binding]; other site 508765002604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765002605 DNA binding site [nucleotide binding] 508765002606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 508765002607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765002608 S-adenosylmethionine binding site [chemical binding]; other site 508765002609 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 508765002610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002612 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765002613 active site 508765002614 motif I; other site 508765002615 motif II; other site 508765002616 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765002617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002618 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765002619 active site 508765002620 motif I; other site 508765002621 motif II; other site 508765002622 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765002623 putative hydrolase; Validated; Region: PRK09248 508765002624 RNase P subunit p30; Region: RNase_P_p30; cl03389 508765002625 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 508765002626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765002627 Coenzyme A binding pocket [chemical binding]; other site 508765002628 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 508765002629 active site 508765002630 multimer interface [polypeptide binding]; other site 508765002631 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 508765002632 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765002633 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 508765002634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002635 dimer interface [polypeptide binding]; other site 508765002636 conserved gate region; other site 508765002637 putative PBP binding loops; other site 508765002638 ABC-ATPase subunit interface; other site 508765002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002640 dimer interface [polypeptide binding]; other site 508765002641 conserved gate region; other site 508765002642 putative PBP binding loops; other site 508765002643 ABC-ATPase subunit interface; other site 508765002644 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508765002645 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 508765002646 Walker A/P-loop; other site 508765002647 ATP binding site [chemical binding]; other site 508765002648 Q-loop/lid; other site 508765002649 ABC transporter signature motif; other site 508765002650 Walker B; other site 508765002651 D-loop; other site 508765002652 H-loop/switch region; other site 508765002653 TOBE domain; Region: TOBE_2; cl01440 508765002654 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 508765002655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765002656 non-specific DNA binding site [nucleotide binding]; other site 508765002657 salt bridge; other site 508765002658 sequence-specific DNA binding site [nucleotide binding]; other site 508765002659 Cupin domain; Region: Cupin_2; cl09118 508765002660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765002661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765002662 Coenzyme A binding pocket [chemical binding]; other site 508765002663 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 508765002664 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 508765002665 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 508765002666 Transglycosylase; Region: Transgly; cl07896 508765002667 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 508765002668 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765002669 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 508765002670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765002671 active site 508765002672 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 508765002673 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 508765002674 HflX GTPase family; Region: HflX; cd01878 508765002675 G1 box; other site 508765002676 GTP/Mg2+ binding site [chemical binding]; other site 508765002677 Switch I region; other site 508765002678 G2 box; other site 508765002679 G3 box; other site 508765002680 Switch II region; other site 508765002681 G4 box; other site 508765002682 G5 box; other site 508765002683 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 508765002684 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 508765002685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765002686 DNA-binding site [nucleotide binding]; DNA binding site 508765002687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765002688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002689 homodimer interface [polypeptide binding]; other site 508765002690 catalytic residue [active] 508765002691 Uncharacterized conserved protein [Function unknown]; Region: COG1739 508765002692 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 508765002693 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 508765002694 Transcriptional regulator; Region: Transcrip_reg; cl00361 508765002695 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 508765002696 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 508765002697 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 508765002698 homodimer interface [polypeptide binding]; other site 508765002699 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002700 catalytic residue [active] 508765002701 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 508765002702 spermidine synthase; Provisional; Region: PRK00811 508765002703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765002704 S-adenosylmethionine binding site [chemical binding]; other site 508765002705 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 508765002706 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508765002707 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 508765002708 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 508765002709 dimer interface [polypeptide binding]; other site 508765002710 active site 508765002711 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765002712 catalytic residues [active] 508765002713 substrate binding site [chemical binding]; other site 508765002714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 508765002715 PAS fold; Region: PAS_4; pfam08448 508765002716 GAF domain; Region: GAF; cl15785 508765002717 PAS domain S-box; Region: sensory_box; TIGR00229 508765002718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765002719 putative active site [active] 508765002720 heme pocket [chemical binding]; other site 508765002721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765002722 dimer interface [polypeptide binding]; other site 508765002723 phosphorylation site [posttranslational modification] 508765002724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765002725 ATP binding site [chemical binding]; other site 508765002726 Mg2+ binding site [ion binding]; other site 508765002727 G-X-G motif; other site 508765002728 Arginase family; Region: Arginase; cl00306 508765002729 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508765002730 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 508765002731 dimer interface [polypeptide binding]; other site 508765002732 active site 508765002733 metal binding site [ion binding]; metal-binding site 508765002734 Cache domain; Region: Cache_1; pfam02743 508765002735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765002736 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765002737 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765002738 dimer interface [polypeptide binding]; other site 508765002739 putative CheW interface [polypeptide binding]; other site 508765002740 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002741 FeS/SAM binding site; other site 508765002742 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 508765002743 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 508765002744 RuvA N terminal domain; Region: RuvA_N; pfam01330 508765002745 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 508765002746 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 508765002747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765002748 Walker A motif; other site 508765002749 ATP binding site [chemical binding]; other site 508765002750 Walker B motif; other site 508765002751 arginine finger; other site 508765002752 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 508765002753 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 508765002754 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 508765002755 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 508765002756 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 508765002757 Preprotein translocase subunit; Region: YajC; cl00806 508765002758 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 508765002759 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 508765002760 Protein export membrane protein; Region: SecD_SecF; cl14618 508765002761 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 508765002762 Protein export membrane protein; Region: SecD_SecF; cl14618 508765002763 DHH family; Region: DHH; pfam01368 508765002764 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 508765002765 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765002766 active site 508765002767 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 508765002768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765002769 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765002770 synthetase active site [active] 508765002771 NTP binding site [chemical binding]; other site 508765002772 metal binding site [ion binding]; metal-binding site 508765002773 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 508765002774 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 508765002775 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 508765002776 putative active site [active] 508765002777 dimerization interface [polypeptide binding]; other site 508765002778 putative tRNAtyr binding site [nucleotide binding]; other site 508765002779 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765002780 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 508765002781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765002782 FeS/SAM binding site; other site 508765002783 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 508765002784 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 508765002785 dimer interface [polypeptide binding]; other site 508765002786 motif 1; other site 508765002787 active site 508765002788 motif 2; other site 508765002789 motif 3; other site 508765002790 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 508765002791 anticodon binding site; other site 508765002792 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 508765002793 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 508765002794 dimer interface [polypeptide binding]; other site 508765002795 anticodon binding site; other site 508765002796 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 508765002797 homodimer interface [polypeptide binding]; other site 508765002798 motif 1; other site 508765002799 active site 508765002800 motif 2; other site 508765002801 GAD domain; Region: GAD; pfam02938 508765002802 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 508765002803 active site 508765002804 motif 3; other site 508765002805 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 508765002806 Protein of unknown function (DUF554); Region: DUF554; cl00784 508765002807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508765002808 active site residue [active] 508765002809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765002810 dimerization interface [polypeptide binding]; other site 508765002811 putative DNA binding site [nucleotide binding]; other site 508765002812 putative Zn2+ binding site [ion binding]; other site 508765002813 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 508765002814 homoserine dehydrogenase; Provisional; Region: PRK06349 508765002815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002816 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 508765002817 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 508765002818 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 508765002819 glycerol kinase; Provisional; Region: glpK; PRK00047 508765002820 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 508765002821 N- and C-terminal domain interface [polypeptide binding]; other site 508765002822 active site 508765002823 MgATP binding site [chemical binding]; other site 508765002824 catalytic site [active] 508765002825 metal binding site [ion binding]; metal-binding site 508765002826 glycerol binding site [chemical binding]; other site 508765002827 homotetramer interface [polypeptide binding]; other site 508765002828 homodimer interface [polypeptide binding]; other site 508765002829 FBP binding site [chemical binding]; other site 508765002830 protein IIAGlc interface [polypeptide binding]; other site 508765002831 Predicted dehydrogenase [General function prediction only]; Region: COG0579 508765002832 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 508765002833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 508765002834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002835 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 508765002836 aspartate kinase; Reviewed; Region: PRK09034 508765002837 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 508765002838 nucleotide binding site [chemical binding]; other site 508765002839 substrate binding site [chemical binding]; other site 508765002840 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 508765002841 allosteric regulatory residue; other site 508765002842 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 508765002843 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 508765002844 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 508765002845 active site 508765002846 dimer interface [polypeptide binding]; other site 508765002847 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 508765002848 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 508765002849 active site 508765002850 FMN binding site [chemical binding]; other site 508765002851 substrate binding site [chemical binding]; other site 508765002852 3Fe-4S cluster binding site [ion binding]; other site 508765002853 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 508765002854 domain interface; other site 508765002855 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 508765002856 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765002857 inner membrane transporter YjeM; Provisional; Region: PRK15238 508765002858 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 508765002859 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765002860 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508765002861 binuclear metal center [ion binding]; other site 508765002862 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765002863 iron binding site [ion binding]; other site 508765002864 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 508765002865 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 508765002866 ATP-binding site [chemical binding]; other site 508765002867 Sugar specificity; other site 508765002868 Pyrimidine base specificity; other site 508765002869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 508765002870 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 508765002871 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765002872 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 508765002873 PhoU domain; Region: PhoU; pfam01895 508765002874 PhoU domain; Region: PhoU; pfam01895 508765002875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765002876 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508765002877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765002878 motif II; other site 508765002879 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 508765002880 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765002881 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 508765002882 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 508765002883 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 508765002884 Cache domain; Region: Cache_1; pfam02743 508765002885 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765002886 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765002887 dimer interface [polypeptide binding]; other site 508765002888 putative CheW interface [polypeptide binding]; other site 508765002889 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765002890 catalytic residues [active] 508765002891 threonine dehydratase; Provisional; Region: PRK08198 508765002892 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 508765002893 tetramer interface [polypeptide binding]; other site 508765002894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765002895 catalytic residue [active] 508765002896 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 508765002897 Uncharacterized conserved protein [Function unknown]; Region: COG2966 508765002898 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 508765002899 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 508765002900 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 508765002901 Cation efflux family; Region: Cation_efflux; cl00316 508765002902 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 508765002903 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508765002904 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508765002905 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765002906 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765002907 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765002908 ABC transporter; Region: ABC_tran_2; pfam12848 508765002909 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765002910 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 508765002911 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 508765002912 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 508765002913 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 508765002914 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 508765002915 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 508765002916 dimer interface [polypeptide binding]; other site 508765002917 glycine-pyridoxal phosphate binding site [chemical binding]; other site 508765002918 active site 508765002919 folate binding site [chemical binding]; other site 508765002920 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 508765002921 putative active site [active] 508765002922 putative metal binding site [ion binding]; other site 508765002923 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 508765002924 active site 508765002925 dimer interface [polypeptide binding]; other site 508765002926 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 508765002927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765002928 NAD(P) binding site [chemical binding]; other site 508765002929 active site 508765002930 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 508765002931 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 508765002932 homodimer interface [polypeptide binding]; other site 508765002933 substrate-cofactor binding pocket; other site 508765002934 catalytic residue [active] 508765002935 NAD synthetase; Reviewed; Region: nadE; PRK02628 508765002936 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 508765002937 multimer interface [polypeptide binding]; other site 508765002938 active site 508765002939 catalytic triad [active] 508765002940 protein interface 1 [polypeptide binding]; other site 508765002941 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 508765002942 homodimer interface [polypeptide binding]; other site 508765002943 NAD binding pocket [chemical binding]; other site 508765002944 ATP binding pocket [chemical binding]; other site 508765002945 Mg binding site [ion binding]; other site 508765002946 active-site loop [active] 508765002947 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 508765002948 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 508765002949 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 508765002950 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508765002951 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765002952 MatE; Region: MatE; cl10513 508765002953 MatE; Region: MatE; cl10513 508765002954 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 508765002955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508765002956 DNA binding residues [nucleotide binding] 508765002957 dimer interface [polypeptide binding]; other site 508765002958 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 508765002959 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765002960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 508765002961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508765002962 substrate binding pocket [chemical binding]; other site 508765002963 membrane-bound complex binding site; other site 508765002964 hinge residues; other site 508765002965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765002966 dimer interface [polypeptide binding]; other site 508765002967 conserved gate region; other site 508765002968 putative PBP binding loops; other site 508765002969 ABC-ATPase subunit interface; other site 508765002970 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 508765002971 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 508765002972 Walker A/P-loop; other site 508765002973 ATP binding site [chemical binding]; other site 508765002974 Q-loop/lid; other site 508765002975 ABC transporter signature motif; other site 508765002976 Walker B; other site 508765002977 D-loop; other site 508765002978 H-loop/switch region; other site 508765002979 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765002980 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 508765002981 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 508765002982 Cl- selectivity filter; other site 508765002983 Cl- binding residues [ion binding]; other site 508765002984 pore gating glutamate residue; other site 508765002985 dimer interface [polypeptide binding]; other site 508765002986 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 508765002987 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 508765002988 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 508765002989 dimerization interface [polypeptide binding]; other site 508765002990 ATP binding site [chemical binding]; other site 508765002991 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 508765002992 dimerization interface [polypeptide binding]; other site 508765002993 ATP binding site [chemical binding]; other site 508765002994 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 508765002995 putative active site [active] 508765002996 catalytic triad [active] 508765002997 AIR carboxylase; Region: AIRC; cl00310 508765002998 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 508765002999 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 508765003000 ATP binding site [chemical binding]; other site 508765003001 active site 508765003002 substrate binding site [chemical binding]; other site 508765003003 amidophosphoribosyltransferase; Provisional; Region: PRK05793 508765003004 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 508765003005 active site 508765003006 tetramer interface [polypeptide binding]; other site 508765003007 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765003008 active site 508765003009 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 508765003010 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 508765003011 dimerization interface [polypeptide binding]; other site 508765003012 putative ATP binding site [chemical binding]; other site 508765003013 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 508765003014 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 508765003015 active site 508765003016 substrate binding site [chemical binding]; other site 508765003017 cosubstrate binding site; other site 508765003018 catalytic site [active] 508765003019 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 508765003020 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 508765003021 purine monophosphate binding site [chemical binding]; other site 508765003022 dimer interface [polypeptide binding]; other site 508765003023 putative catalytic residues [active] 508765003024 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 508765003025 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 508765003026 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 508765003027 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 508765003028 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765003029 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 508765003030 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 508765003031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003032 CoA-ligase; Region: Ligase_CoA; cl02894 508765003033 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 508765003034 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 508765003035 iron-sulfur cluster [ion binding]; other site 508765003036 [2Fe-2S] cluster binding site [ion binding]; other site 508765003037 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508765003038 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508765003039 DNA binding residues [nucleotide binding] 508765003040 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 508765003041 LytTr DNA-binding domain; Region: LytTR; cl04498 508765003042 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765003043 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 508765003044 Helix-turn-helix domains; Region: HTH; cl00088 508765003045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765003046 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765003047 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765003048 Walker A/P-loop; other site 508765003049 ATP binding site [chemical binding]; other site 508765003050 Q-loop/lid; other site 508765003051 ABC transporter signature motif; other site 508765003052 Walker B; other site 508765003053 D-loop; other site 508765003054 H-loop/switch region; other site 508765003055 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765003056 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765003057 Walker A/P-loop; other site 508765003058 ATP binding site [chemical binding]; other site 508765003059 Q-loop/lid; other site 508765003060 ABC transporter signature motif; other site 508765003061 Walker B; other site 508765003062 D-loop; other site 508765003063 H-loop/switch region; other site 508765003064 OpgC protein; Region: OpgC_C; cl00792 508765003065 sensory histidine kinase CreC; Provisional; Region: PRK11100 508765003066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003067 ATP binding site [chemical binding]; other site 508765003068 Mg2+ binding site [ion binding]; other site 508765003069 G-X-G motif; other site 508765003070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003072 active site 508765003073 phosphorylation site [posttranslational modification] 508765003074 intermolecular recognition site; other site 508765003075 dimerization interface [polypeptide binding]; other site 508765003076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003077 DNA binding site [nucleotide binding] 508765003078 TraX protein; Region: TraX; cl05434 508765003079 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765003080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003082 active site 508765003083 phosphorylation site [posttranslational modification] 508765003084 intermolecular recognition site; other site 508765003085 dimerization interface [polypeptide binding]; other site 508765003086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003087 DNA binding site [nucleotide binding] 508765003088 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 508765003089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765003090 dimerization interface [polypeptide binding]; other site 508765003091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765003092 dimer interface [polypeptide binding]; other site 508765003093 phosphorylation site [posttranslational modification] 508765003094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003095 ATP binding site [chemical binding]; other site 508765003096 Mg2+ binding site [ion binding]; other site 508765003097 G-X-G motif; other site 508765003098 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 508765003099 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 508765003100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765003101 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 508765003102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765003103 putative substrate translocation pore; other site 508765003104 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 508765003105 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765003106 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 508765003107 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 508765003108 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003109 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 508765003110 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508765003111 Helix-turn-helix domains; Region: HTH; cl00088 508765003112 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 508765003113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508765003114 TPR repeat; Region: TPR_11; pfam13414 508765003115 binding surface 508765003116 TPR motif; other site 508765003117 TPR repeat; Region: TPR_11; pfam13414 508765003118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765003119 binding surface 508765003120 TPR motif; other site 508765003121 TPR repeat; Region: TPR_11; pfam13414 508765003122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765003123 TPR repeat; Region: TPR_11; pfam13414 508765003124 binding surface 508765003125 TPR motif; other site 508765003126 TPR repeat; Region: TPR_11; pfam13414 508765003127 Flavin Reductases; Region: FlaRed; cl00801 508765003128 Helix-turn-helix domains; Region: HTH; cl00088 508765003129 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 508765003130 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 508765003131 dimer interface [polypeptide binding]; other site 508765003132 active site 508765003133 CoA binding pocket [chemical binding]; other site 508765003134 Phosphopantetheine attachment site; Region: PP-binding; cl09936 508765003135 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 508765003136 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 508765003137 FMN binding site [chemical binding]; other site 508765003138 substrate binding site [chemical binding]; other site 508765003139 putative catalytic residue [active] 508765003140 Acyl transferase domain; Region: Acyl_transf_1; cl08282 508765003141 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 508765003142 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 508765003143 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 508765003144 NAD(P) binding site [chemical binding]; other site 508765003145 homotetramer interface [polypeptide binding]; other site 508765003146 homodimer interface [polypeptide binding]; other site 508765003147 active site 508765003148 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 508765003149 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 508765003150 dimer interface [polypeptide binding]; other site 508765003151 active site 508765003152 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 508765003153 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508765003154 carboxyltransferase (CT) interaction site; other site 508765003155 biotinylation site [posttranslational modification]; other site 508765003156 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 508765003157 biotin carboxylase; Validated; Region: PRK05586 508765003158 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765003159 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765003160 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 508765003161 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 508765003162 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 508765003163 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 508765003164 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 508765003165 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 508765003166 HutP; Region: HutP; cl07944 508765003167 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 508765003168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003169 NAD(P) binding site [chemical binding]; other site 508765003170 active site 508765003171 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 508765003172 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 508765003173 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 508765003174 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765003175 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 508765003176 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765003177 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508765003178 Ligand binding site; other site 508765003179 metal-binding site 508765003180 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 508765003181 putative MPT binding site; other site 508765003182 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 508765003183 trimer interface [polypeptide binding]; other site 508765003184 dimer interface [polypeptide binding]; other site 508765003185 putative active site [active] 508765003186 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 508765003187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003188 FeS/SAM binding site; other site 508765003189 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 508765003190 MOSC domain; Region: MOSC; pfam03473 508765003191 recombination factor protein RarA; Reviewed; Region: PRK13342 508765003192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765003193 Walker A motif; other site 508765003194 ATP binding site [chemical binding]; other site 508765003195 Walker B motif; other site 508765003196 arginine finger; other site 508765003197 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 508765003198 Helix-turn-helix domains; Region: HTH; cl00088 508765003199 Rrf2 family protein; Region: rrf2_super; TIGR00738 508765003200 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765003201 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 508765003202 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765003203 catalytic residue [active] 508765003204 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 508765003205 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 508765003206 trimerization site [polypeptide binding]; other site 508765003207 active site 508765003208 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 508765003209 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 508765003210 Ligand Binding Site [chemical binding]; other site 508765003211 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 508765003212 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 508765003213 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765003214 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 508765003215 T-box leader 508765003216 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 508765003217 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 508765003218 motif 1; other site 508765003219 active site 508765003220 motif 2; other site 508765003221 motif 3; other site 508765003222 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 508765003223 DHHA1 domain; Region: DHHA1; pfam02272 508765003224 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 508765003225 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 508765003226 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 508765003227 ferric uptake regulator; Provisional; Region: fur; PRK09462 508765003228 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508765003229 metal binding site 2 [ion binding]; metal-binding site 508765003230 putative DNA binding helix; other site 508765003231 metal binding site 1 [ion binding]; metal-binding site 508765003232 dimer interface [polypeptide binding]; other site 508765003233 structural Zn2+ binding site [ion binding]; other site 508765003234 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 508765003235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765003236 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 508765003237 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 508765003238 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 508765003239 G1 box; other site 508765003240 putative GEF interaction site [polypeptide binding]; other site 508765003241 GTP/Mg2+ binding site [chemical binding]; other site 508765003242 Switch I region; other site 508765003243 G2 box; other site 508765003244 G3 box; other site 508765003245 Switch II region; other site 508765003246 G4 box; other site 508765003247 G5 box; other site 508765003248 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 508765003249 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 508765003250 YceG-like family; Region: YceG; pfam02618 508765003251 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 508765003252 dimerization interface [polypeptide binding]; other site 508765003253 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 508765003254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765003255 S-adenosylmethionine binding site [chemical binding]; other site 508765003256 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 508765003257 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 508765003258 Peptidase family U32; Region: Peptidase_U32; cl03113 508765003259 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765003260 sporulation sigma factor SigK; Reviewed; Region: PRK05803 508765003261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765003262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765003263 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 508765003264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003265 Walker A motif; other site 508765003266 ATP binding site [chemical binding]; other site 508765003267 Walker B motif; other site 508765003268 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 508765003269 Cell division protein FtsA; Region: FtsA; cl11496 508765003270 Cell division protein FtsA; Region: FtsA; cl11496 508765003271 cell division protein FtsZ; Validated; Region: PRK09330 508765003272 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 508765003273 nucleotide binding site [chemical binding]; other site 508765003274 SulA interaction site; other site 508765003275 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 508765003276 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 508765003277 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 508765003278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765003279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765003280 DNA binding residues [nucleotide binding] 508765003281 sporulation sigma factor SigG; Reviewed; Region: PRK08215 508765003282 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765003283 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 508765003284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765003285 DNA binding residues [nucleotide binding] 508765003286 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 508765003287 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 508765003288 ATP cone domain; Region: ATP-cone; pfam03477 508765003289 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 508765003290 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 508765003291 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 508765003292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003293 active site 508765003294 phosphorylation site [posttranslational modification] 508765003295 intermolecular recognition site; other site 508765003296 dimerization interface [polypeptide binding]; other site 508765003297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003298 DNA binding site [nucleotide binding] 508765003299 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 508765003300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765003301 dimerization interface [polypeptide binding]; other site 508765003302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 508765003303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765003304 dimer interface [polypeptide binding]; other site 508765003305 phosphorylation site [posttranslational modification] 508765003306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003307 ATP binding site [chemical binding]; other site 508765003308 Mg2+ binding site [ion binding]; other site 508765003309 G-X-G motif; other site 508765003310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765003311 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 508765003312 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 508765003313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765003314 dimer interface [polypeptide binding]; other site 508765003315 conserved gate region; other site 508765003316 putative PBP binding loops; other site 508765003317 ABC-ATPase subunit interface; other site 508765003318 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 508765003319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765003320 dimer interface [polypeptide binding]; other site 508765003321 conserved gate region; other site 508765003322 putative PBP binding loops; other site 508765003323 ABC-ATPase subunit interface; other site 508765003324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 508765003325 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 508765003326 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 508765003327 Walker A/P-loop; other site 508765003328 ATP binding site [chemical binding]; other site 508765003329 Q-loop/lid; other site 508765003330 ABC transporter signature motif; other site 508765003331 Walker B; other site 508765003332 D-loop; other site 508765003333 H-loop/switch region; other site 508765003334 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 508765003335 PhoU domain; Region: PhoU; pfam01895 508765003336 PhoU domain; Region: PhoU; pfam01895 508765003337 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508765003338 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 508765003339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003340 FeS/SAM binding site; other site 508765003341 Protein of unknown function (DUF512); Region: DUF512; pfam04459 508765003342 GTP-binding protein Der; Reviewed; Region: PRK00093 508765003343 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 508765003344 G1 box; other site 508765003345 GTP/Mg2+ binding site [chemical binding]; other site 508765003346 Switch I region; other site 508765003347 G2 box; other site 508765003348 Switch II region; other site 508765003349 G3 box; other site 508765003350 G4 box; other site 508765003351 G5 box; other site 508765003352 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 508765003353 G1 box; other site 508765003354 GTP/Mg2+ binding site [chemical binding]; other site 508765003355 Switch I region; other site 508765003356 G2 box; other site 508765003357 G3 box; other site 508765003358 Switch II region; other site 508765003359 G4 box; other site 508765003360 G5 box; other site 508765003361 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 508765003362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003363 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 508765003364 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 508765003365 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 508765003366 active site 508765003367 homotetramer interface [polypeptide binding]; other site 508765003368 homodimer interface [polypeptide binding]; other site 508765003369 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765003370 hypothetical protein; Provisional; Region: PRK11820 508765003371 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 508765003372 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 508765003373 Domain of unknown function (DUF370); Region: DUF370; cl00898 508765003374 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 508765003375 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 508765003376 catalytic site [active] 508765003377 G-X2-G-X-G-K; other site 508765003378 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 508765003379 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 508765003380 Flavoprotein; Region: Flavoprotein; cl08021 508765003381 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 508765003382 primosome assembly protein PriA; Validated; Region: PRK05580 508765003383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765003384 ATP binding site [chemical binding]; other site 508765003385 putative Mg++ binding site [ion binding]; other site 508765003386 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003387 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508765003388 active site 508765003389 catalytic residues [active] 508765003390 metal binding site [ion binding]; metal-binding site 508765003391 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 508765003392 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 508765003393 putative active site [active] 508765003394 substrate binding site [chemical binding]; other site 508765003395 putative cosubstrate binding site; other site 508765003396 catalytic site [active] 508765003397 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 508765003398 substrate binding site [chemical binding]; other site 508765003399 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 508765003400 16S rRNA methyltransferase B; Provisional; Region: PRK14902 508765003401 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 508765003402 putative RNA binding site [nucleotide binding]; other site 508765003403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765003404 S-adenosylmethionine binding site [chemical binding]; other site 508765003405 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 508765003406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003407 FeS/SAM binding site; other site 508765003408 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 508765003409 Protein phosphatase 2C; Region: PP2C; pfam00481 508765003410 active site 508765003411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 508765003412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 508765003413 active site 508765003414 ATP binding site [chemical binding]; other site 508765003415 substrate binding site [chemical binding]; other site 508765003416 activation loop (A-loop); other site 508765003417 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508765003418 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508765003419 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 508765003420 GTPase RsgA; Reviewed; Region: PRK00098 508765003421 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 508765003422 RNA binding site [nucleotide binding]; other site 508765003423 homodimer interface [polypeptide binding]; other site 508765003424 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 508765003425 GTPase/Zn-binding domain interface [polypeptide binding]; other site 508765003426 GTP/Mg2+ binding site [chemical binding]; other site 508765003427 G4 box; other site 508765003428 G5 box; other site 508765003429 G1 box; other site 508765003430 Switch I region; other site 508765003431 G2 box; other site 508765003432 G3 box; other site 508765003433 Switch II region; other site 508765003434 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 508765003435 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 508765003436 substrate binding site [chemical binding]; other site 508765003437 hexamer interface [polypeptide binding]; other site 508765003438 metal binding site [ion binding]; metal-binding site 508765003439 Thiamine pyrophosphokinase; Region: TPK; cd07995 508765003440 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 508765003441 active site 508765003442 dimerization interface [polypeptide binding]; other site 508765003443 thiamine binding site [chemical binding]; other site 508765003444 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 508765003445 Asp23 family; Region: Asp23; cl00574 508765003446 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 508765003447 DAK2 domain; Region: Dak2; cl03685 508765003448 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765003449 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 508765003450 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 508765003451 ssDNA binding site; other site 508765003452 generic binding surface II; other site 508765003453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765003454 ATP binding site [chemical binding]; other site 508765003455 putative Mg++ binding site [ion binding]; other site 508765003456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765003457 nucleotide binding region [chemical binding]; other site 508765003458 ATP-binding site [chemical binding]; other site 508765003459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765003460 S-adenosylmethionine binding site [chemical binding]; other site 508765003461 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 508765003462 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 508765003463 active site 508765003464 (T/H)XGH motif; other site 508765003465 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 508765003466 Nucleoside recognition; Region: Gate; cl00486 508765003467 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508765003468 hypothetical protein; Provisional; Region: PRK13670 508765003469 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 508765003470 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 508765003471 Acetokinase family; Region: Acetate_kinase; cl01029 508765003472 propionate/acetate kinase; Provisional; Region: PRK12379 508765003473 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 508765003474 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 508765003475 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 508765003476 Phosphopantetheine attachment site; Region: PP-binding; cl09936 508765003477 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 508765003478 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 508765003479 dimerization interface [polypeptide binding]; other site 508765003480 active site 508765003481 metal binding site [ion binding]; metal-binding site 508765003482 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 508765003483 dsRNA binding site [nucleotide binding]; other site 508765003484 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508765003485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003486 FeS/SAM binding site; other site 508765003487 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508765003488 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 508765003489 Walker A/P-loop; other site 508765003490 ATP binding site [chemical binding]; other site 508765003491 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 508765003492 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 508765003493 ABC transporter signature motif; other site 508765003494 Walker B; other site 508765003495 D-loop; other site 508765003496 H-loop/switch region; other site 508765003497 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 508765003498 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 508765003499 P loop; other site 508765003500 GTP binding site [chemical binding]; other site 508765003501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765003502 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 508765003503 signal recognition particle protein; Provisional; Region: PRK10867 508765003504 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 508765003505 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 508765003506 P loop; other site 508765003507 GTP binding site [chemical binding]; other site 508765003508 Signal peptide binding domain; Region: SRP_SPB; pfam02978 508765003509 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 508765003510 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 508765003511 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 508765003512 RimM N-terminal domain; Region: RimM; pfam01782 508765003513 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 508765003514 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 508765003515 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 508765003516 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 508765003517 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 508765003518 GTP/Mg2+ binding site [chemical binding]; other site 508765003519 G4 box; other site 508765003520 G5 box; other site 508765003521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003522 G1 box; other site 508765003523 G1 box; other site 508765003524 GTP/Mg2+ binding site [chemical binding]; other site 508765003525 Switch I region; other site 508765003526 G2 box; other site 508765003527 G2 box; other site 508765003528 Switch I region; other site 508765003529 G3 box; other site 508765003530 G3 box; other site 508765003531 Switch II region; other site 508765003532 Switch II region; other site 508765003533 G4 box; other site 508765003534 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 508765003535 RNA/DNA hybrid binding site [nucleotide binding]; other site 508765003536 active site 508765003537 Restriction endonuclease; Region: Mrr_cat; cl00516 508765003538 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 508765003539 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 508765003540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765003541 Walker A motif; other site 508765003542 ATP binding site [chemical binding]; other site 508765003543 Walker B motif; other site 508765003544 arginine finger; other site 508765003545 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 508765003546 5'-3' exonuclease; Provisional; Region: PRK14976 508765003547 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 508765003548 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 508765003549 DNA topoisomerase I; Validated; Region: PRK05582 508765003550 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 508765003551 active site 508765003552 interdomain interaction site; other site 508765003553 putative metal-binding site [ion binding]; other site 508765003554 nucleotide binding site [chemical binding]; other site 508765003555 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 508765003556 domain I; other site 508765003557 DNA binding groove [nucleotide binding] 508765003558 phosphate binding site [ion binding]; other site 508765003559 domain II; other site 508765003560 domain III; other site 508765003561 nucleotide binding site [chemical binding]; other site 508765003562 catalytic site [active] 508765003563 domain IV; other site 508765003564 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508765003565 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508765003566 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 508765003567 transcriptional repressor CodY; Validated; Region: PRK04158 508765003568 CodY GAF-like domain; Region: CodY; pfam06018 508765003569 Helix-turn-helix domains; Region: HTH; cl00088 508765003570 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 508765003571 rRNA interaction site [nucleotide binding]; other site 508765003572 S8 interaction site; other site 508765003573 putative laminin-1 binding site; other site 508765003574 elongation factor Ts; Provisional; Region: tsf; PRK09377 508765003575 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 508765003576 Elongation factor TS; Region: EF_TS; pfam00889 508765003577 Elongation factor TS; Region: EF_TS; pfam00889 508765003578 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 508765003579 putative nucleotide binding site [chemical binding]; other site 508765003580 uridine monophosphate binding site [chemical binding]; other site 508765003581 homohexameric interface [polypeptide binding]; other site 508765003582 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 508765003583 hinge region; other site 508765003584 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 508765003585 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 508765003586 catalytic residue [active] 508765003587 putative FPP diphosphate binding site; other site 508765003588 putative FPP binding hydrophobic cleft; other site 508765003589 dimer interface [polypeptide binding]; other site 508765003590 putative IPP diphosphate binding site; other site 508765003591 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 508765003592 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765003593 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 508765003594 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 508765003595 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 508765003596 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 508765003597 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 508765003598 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 508765003599 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 508765003600 active site 508765003601 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508765003602 protein binding site [polypeptide binding]; other site 508765003603 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 508765003604 putative substrate binding region [chemical binding]; other site 508765003605 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 508765003606 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 508765003607 DNA polymerase III PolC; Validated; Region: polC; PRK00448 508765003608 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 508765003609 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 508765003610 generic binding surface II; other site 508765003611 generic binding surface I; other site 508765003612 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508765003613 active site 508765003614 substrate binding site [chemical binding]; other site 508765003615 catalytic site [active] 508765003616 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 508765003617 ribosome maturation protein RimP; Reviewed; Region: PRK00092 508765003618 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 508765003619 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 508765003620 Sm1 motif; other site 508765003621 D3 - B interaction site; other site 508765003622 D1 - D2 interaction site; other site 508765003623 Hfq - Hfq interaction site; other site 508765003624 RNA binding pocket [nucleotide binding]; other site 508765003625 Sm2 motif; other site 508765003626 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 508765003627 NusA N-terminal domain; Region: NusA_N; pfam08529 508765003628 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 508765003629 RNA binding site [nucleotide binding]; other site 508765003630 homodimer interface [polypeptide binding]; other site 508765003631 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 508765003632 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 508765003633 G-X-X-G motif; other site 508765003634 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 508765003635 putative RNA binding cleft [nucleotide binding]; other site 508765003636 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 508765003637 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 508765003638 translation initiation factor IF-2; Region: IF-2; TIGR00487 508765003639 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 508765003640 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 508765003641 G1 box; other site 508765003642 putative GEF interaction site [polypeptide binding]; other site 508765003643 GTP/Mg2+ binding site [chemical binding]; other site 508765003644 Switch I region; other site 508765003645 G2 box; other site 508765003646 G3 box; other site 508765003647 Switch II region; other site 508765003648 G4 box; other site 508765003649 G5 box; other site 508765003650 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 508765003651 Translation-initiation factor 2; Region: IF-2; pfam11987 508765003652 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 508765003653 Ribosome-binding factor A; Region: RBFA; cl00542 508765003654 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 508765003655 DHH family; Region: DHH; pfam01368 508765003656 DHHA1 domain; Region: DHHA1; pfam02272 508765003657 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 508765003658 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 508765003659 RNA binding site [nucleotide binding]; other site 508765003660 active site 508765003661 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 508765003662 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 508765003663 active site 508765003664 Riboflavin kinase; Region: Flavokinase; cl03312 508765003665 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 508765003666 16S/18S rRNA binding site [nucleotide binding]; other site 508765003667 S13e-L30e interaction site [polypeptide binding]; other site 508765003668 25S rRNA binding site [nucleotide binding]; other site 508765003669 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 508765003670 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 508765003671 RNase E interface [polypeptide binding]; other site 508765003672 trimer interface [polypeptide binding]; other site 508765003673 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 508765003674 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 508765003675 RNase E interface [polypeptide binding]; other site 508765003676 trimer interface [polypeptide binding]; other site 508765003677 active site 508765003678 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 508765003679 putative nucleic acid binding region [nucleotide binding]; other site 508765003680 G-X-X-G motif; other site 508765003681 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 508765003682 RNA binding site [nucleotide binding]; other site 508765003683 domain interface; other site 508765003684 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508765003685 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508765003686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508765003687 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 508765003688 aspartate kinase I; Reviewed; Region: PRK08210 508765003689 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 508765003690 putative catalytic residues [active] 508765003691 putative nucleotide binding site [chemical binding]; other site 508765003692 putative aspartate binding site [chemical binding]; other site 508765003693 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 508765003694 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 508765003695 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 508765003696 Clp protease; Region: CLP_protease; pfam00574 508765003697 active site 508765003698 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 508765003699 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 508765003700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003701 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 508765003702 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 508765003703 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508765003704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765003705 FeS/SAM binding site; other site 508765003706 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 508765003707 recombinase A; Provisional; Region: recA; PRK09354 508765003708 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 508765003709 hexamer interface [polypeptide binding]; other site 508765003710 Walker A motif; other site 508765003711 ATP binding site [chemical binding]; other site 508765003712 Walker B motif; other site 508765003713 phosphodiesterase; Provisional; Region: PRK12704 508765003714 Plant ATP synthase F0; Region: YMF19; cl07975 508765003715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765003716 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 508765003717 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 508765003718 dimerization domain swap beta strand [polypeptide binding]; other site 508765003719 regulatory protein interface [polypeptide binding]; other site 508765003720 active site 508765003721 regulatory phosphorylation site [posttranslational modification]; other site 508765003722 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 508765003723 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 508765003724 tetramer interface [polypeptide binding]; other site 508765003725 active site 508765003726 NlpC/P60 family; Region: NLPC_P60; cl11438 508765003727 ST7 protein; Region: ST7; pfam04184 508765003728 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 508765003729 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 508765003730 catalytic motif [active] 508765003731 Zn binding site [ion binding]; other site 508765003732 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 508765003733 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 508765003734 Lumazine binding domain; Region: Lum_binding; pfam00677 508765003735 Lumazine binding domain; Region: Lum_binding; pfam00677 508765003736 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 508765003737 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 508765003738 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 508765003739 dimerization interface [polypeptide binding]; other site 508765003740 active site 508765003741 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 508765003742 homopentamer interface [polypeptide binding]; other site 508765003743 active site 508765003744 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765003745 Helix-turn-helix domains; Region: HTH; cl00088 508765003746 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765003747 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765003748 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 508765003749 putative active site [active] 508765003750 metal binding site [ion binding]; metal-binding site 508765003751 hypothetical protein; Provisional; Region: PRK08185 508765003752 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508765003753 intersubunit interface [polypeptide binding]; other site 508765003754 active site 508765003755 zinc binding site [ion binding]; other site 508765003756 Na+ binding site [ion binding]; other site 508765003757 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 508765003758 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765003759 substrate binding site [chemical binding]; other site 508765003760 ATP binding site [chemical binding]; other site 508765003761 KduI/IolB family; Region: KduI; cl01508 508765003762 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 508765003763 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765003764 PYR/PP interface [polypeptide binding]; other site 508765003765 dimer interface [polypeptide binding]; other site 508765003766 TPP binding site [chemical binding]; other site 508765003767 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 508765003768 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 508765003769 TPP-binding site; other site 508765003770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765003771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003772 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 508765003773 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 508765003774 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 508765003775 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 508765003776 putative transporter; Provisional; Region: PRK10484 508765003777 Sodium:solute symporter family; Region: SSF; cl00456 508765003778 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508765003779 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508765003780 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508765003781 putative active site [active] 508765003782 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 508765003783 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 508765003784 N- and C-terminal domain interface [polypeptide binding]; other site 508765003785 putative active site [active] 508765003786 catalytic site [active] 508765003787 metal binding site [ion binding]; metal-binding site 508765003788 carbohydrate binding site [chemical binding]; other site 508765003789 ATP binding site [chemical binding]; other site 508765003790 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 508765003791 gluconate transporter; Region: gntP; TIGR00791 508765003792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003793 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 508765003794 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 508765003795 dimer interface [polypeptide binding]; other site 508765003796 ADP-ribose binding site [chemical binding]; other site 508765003797 active site 508765003798 nudix motif; other site 508765003799 metal binding site [ion binding]; metal-binding site 508765003800 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765003801 T-box leader 508765003802 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 508765003803 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 508765003804 putative active site [active] 508765003805 metal binding site [ion binding]; metal-binding site 508765003806 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 508765003807 2-isopropylmalate synthase; Validated; Region: PRK03739 508765003808 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 508765003809 active site 508765003810 catalytic residues [active] 508765003811 metal binding site [ion binding]; metal-binding site 508765003812 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 508765003813 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 508765003814 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765003815 putative active site [active] 508765003816 putative metal binding site [ion binding]; other site 508765003817 leucine-rich repeat receptor-like protein kinase; Provisional; Region: PLN00113 508765003818 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765003819 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 508765003820 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 508765003821 putative oligomer interface [polypeptide binding]; other site 508765003822 putative active site [active] 508765003823 metal binding site [ion binding]; metal-binding site 508765003824 mycofactocin radical SAM maturase; Region: rSAM_MSMEG_1423; TIGR03962 508765003825 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765003826 MatE; Region: MatE; cl10513 508765003827 MatE; Region: MatE; cl10513 508765003828 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 508765003829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003830 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 508765003831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003832 Predicted permease; Region: DUF318; pfam03773 508765003833 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 508765003834 octamerization interface [polypeptide binding]; other site 508765003835 diferric-oxygen binding site [ion binding]; other site 508765003836 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 508765003837 EamA-like transporter family; Region: EamA; cl01037 508765003838 helicase 45; Provisional; Region: PTZ00424 508765003839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003840 ATP binding site [chemical binding]; other site 508765003841 putative Mg++ binding site [ion binding]; other site 508765003842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765003843 nucleotide binding region [chemical binding]; other site 508765003844 ATP-binding site [chemical binding]; other site 508765003845 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 508765003846 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765003847 ATP binding site [chemical binding]; other site 508765003848 Mg++ binding site [ion binding]; other site 508765003849 motif III; other site 508765003850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765003851 nucleotide binding region [chemical binding]; other site 508765003852 ATP-binding site [chemical binding]; other site 508765003853 DbpA RNA binding domain; Region: DbpA; pfam03880 508765003854 methionine aminopeptidase; Provisional; Region: PRK12318 508765003855 SEC-C motif; Region: SEC-C; pfam02810 508765003856 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 508765003857 active site 508765003858 TIR domain; Region: TIR_2; cl15770 508765003859 TIR domain; Region: TIR_2; cl15770 508765003860 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 508765003861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003862 active site 508765003863 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 508765003864 dimerization interface [polypeptide binding]; other site 508765003865 active site 508765003866 TIR domain; Region: TIR_2; cl15770 508765003867 TIR domain; Region: TIR_2; cl15770 508765003868 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 508765003869 TIR domain; Region: TIR_2; cl15770 508765003870 Integrase core domain; Region: rve; cl01316 508765003871 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 508765003872 Ligand binding site [chemical binding]; other site 508765003873 Electron transfer flavoprotein domain; Region: ETF; pfam01012 508765003874 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 508765003875 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 508765003876 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765003877 L-lactate permease; Region: Lactate_perm; cl00701 508765003878 glycolate transporter; Provisional; Region: PRK09695 508765003879 FAD binding domain; Region: FAD_binding_4; pfam01565 508765003880 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 508765003881 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765003882 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765003883 FAD binding site [chemical binding]; other site 508765003884 homotetramer interface [polypeptide binding]; other site 508765003885 substrate binding pocket [chemical binding]; other site 508765003886 catalytic base [active] 508765003887 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765003888 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 508765003889 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 508765003890 dimer interface [polypeptide binding]; other site 508765003891 active site 508765003892 heme binding site [chemical binding]; other site 508765003893 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 508765003894 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 508765003895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003896 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 508765003897 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 508765003898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765003899 Helix-turn-helix domains; Region: HTH; cl00088 508765003900 transcriptional regulator SlyA; Provisional; Region: PRK03573 508765003901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765003902 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003903 Walker A/P-loop; other site 508765003904 ATP binding site [chemical binding]; other site 508765003905 Q-loop/lid; other site 508765003906 ABC transporter signature motif; other site 508765003907 Walker B; other site 508765003908 D-loop; other site 508765003909 H-loop/switch region; other site 508765003910 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765003911 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 508765003912 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765003913 active pocket/dimerization site; other site 508765003914 active site 508765003915 phosphorylation site [posttranslational modification] 508765003916 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 508765003917 active site 508765003918 phosphorylation site [posttranslational modification] 508765003919 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 508765003920 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 508765003921 Domain of unknown function (DUF956); Region: DUF956; cl01917 508765003922 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 508765003923 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 508765003924 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 508765003925 putative active site [active] 508765003926 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003928 active site 508765003929 phosphorylation site [posttranslational modification] 508765003930 intermolecular recognition site; other site 508765003931 dimerization interface [polypeptide binding]; other site 508765003932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003933 DNA binding site [nucleotide binding] 508765003934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765003935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003936 ATP binding site [chemical binding]; other site 508765003937 Mg2+ binding site [ion binding]; other site 508765003938 G-X-G motif; other site 508765003939 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 508765003940 FtsX-like permease family; Region: FtsX; cl15850 508765003941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765003942 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765003943 Walker A/P-loop; other site 508765003944 ATP binding site [chemical binding]; other site 508765003945 Q-loop/lid; other site 508765003946 ABC transporter signature motif; other site 508765003947 Walker B; other site 508765003948 D-loop; other site 508765003949 H-loop/switch region; other site 508765003950 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765003951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765003952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765003953 active site 508765003954 phosphorylation site [posttranslational modification] 508765003955 intermolecular recognition site; other site 508765003956 dimerization interface [polypeptide binding]; other site 508765003957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765003958 DNA binding site [nucleotide binding] 508765003959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765003960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765003961 dimer interface [polypeptide binding]; other site 508765003962 phosphorylation site [posttranslational modification] 508765003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765003964 ATP binding site [chemical binding]; other site 508765003965 Mg2+ binding site [ion binding]; other site 508765003966 G-X-G motif; other site 508765003967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765003968 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 508765003969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765003970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765003971 dimer interface [polypeptide binding]; other site 508765003972 conserved gate region; other site 508765003973 putative PBP binding loops; other site 508765003974 ABC-ATPase subunit interface; other site 508765003975 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 508765003976 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765003977 Walker A/P-loop; other site 508765003978 ATP binding site [chemical binding]; other site 508765003979 Q-loop/lid; other site 508765003980 ABC transporter signature motif; other site 508765003981 Walker B; other site 508765003982 D-loop; other site 508765003983 H-loop/switch region; other site 508765003984 TOBE domain; Region: TOBE_2; cl01440 508765003985 Domain of unknown function (DUF364); Region: DUF364; pfam04016 508765003986 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 508765003987 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 508765003988 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765003989 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 508765003990 active site 508765003991 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765003992 asparagine synthetase B; Provisional; Region: asnB; PRK09431 508765003993 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 508765003994 dimer interface [polypeptide binding]; other site 508765003995 active site 508765003996 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 508765003997 Ligand Binding Site [chemical binding]; other site 508765003998 Molecular Tunnel; other site 508765003999 T-box leader 508765004000 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 508765004001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765004002 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 508765004003 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 508765004004 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 508765004005 active site 508765004006 ATP binding site [chemical binding]; other site 508765004007 Phosphotransferase enzyme family; Region: APH; pfam01636 508765004008 substrate binding site [chemical binding]; other site 508765004009 dimer interface [polypeptide binding]; other site 508765004010 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 508765004011 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 508765004012 putative binding site residues; other site 508765004013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765004014 ABC-ATPase subunit interface; other site 508765004015 dimer interface [polypeptide binding]; other site 508765004016 putative PBP binding regions; other site 508765004017 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765004018 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765004019 Walker A/P-loop; other site 508765004020 ATP binding site [chemical binding]; other site 508765004021 Q-loop/lid; other site 508765004022 ABC transporter signature motif; other site 508765004023 Walker B; other site 508765004024 D-loop; other site 508765004025 H-loop/switch region; other site 508765004026 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 508765004027 Ligand Binding Site [chemical binding]; other site 508765004028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004030 active site 508765004031 phosphorylation site [posttranslational modification] 508765004032 intermolecular recognition site; other site 508765004033 dimerization interface [polypeptide binding]; other site 508765004034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004035 DNA binding site [nucleotide binding] 508765004036 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765004037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004038 Walker A/P-loop; other site 508765004039 ATP binding site [chemical binding]; other site 508765004040 Q-loop/lid; other site 508765004041 ABC transporter signature motif; other site 508765004042 Walker B; other site 508765004043 D-loop; other site 508765004044 H-loop/switch region; other site 508765004045 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508765004046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004047 dimer interface [polypeptide binding]; other site 508765004048 phosphorylation site [posttranslational modification] 508765004049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004050 ATP binding site [chemical binding]; other site 508765004051 Mg2+ binding site [ion binding]; other site 508765004052 G-X-G motif; other site 508765004053 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 508765004054 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765004055 Helix-turn-helix domains; Region: HTH; cl00088 508765004056 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765004057 MatE; Region: MatE; cl10513 508765004058 MatE; Region: MatE; cl10513 508765004059 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 508765004060 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 508765004061 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 508765004062 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 508765004063 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765004064 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 508765004065 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 508765004066 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 508765004067 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 508765004068 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 508765004069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004070 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004071 putative substrate translocation pore; other site 508765004072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004074 putative substrate translocation pore; other site 508765004075 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 508765004076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004077 Walker A/P-loop; other site 508765004078 ATP binding site [chemical binding]; other site 508765004079 Q-loop/lid; other site 508765004080 ABC transporter signature motif; other site 508765004081 Walker B; other site 508765004082 D-loop; other site 508765004083 H-loop/switch region; other site 508765004084 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765004085 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765004086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765004087 motif II; other site 508765004088 ykoK leader 508765004089 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 508765004090 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 508765004091 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765004092 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765004093 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765004094 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765004095 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765004096 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 508765004097 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 508765004098 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 508765004099 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 508765004100 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 508765004101 trimer interface [polypeptide binding]; other site 508765004102 active site 508765004103 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 508765004104 xanthine permease; Region: pbuX; TIGR03173 508765004105 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765004106 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765004107 FAD binding site [chemical binding]; other site 508765004108 homotetramer interface [polypeptide binding]; other site 508765004109 substrate binding pocket [chemical binding]; other site 508765004110 catalytic base [active] 508765004111 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 508765004112 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508765004113 Rubredoxin; Region: Rubredoxin; pfam00301 508765004114 iron binding site [ion binding]; other site 508765004115 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765004116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765004117 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765004118 inner membrane transporter YjeM; Provisional; Region: PRK15238 508765004119 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765004120 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 508765004121 DNA binding residues [nucleotide binding] 508765004122 putative dimer interface [polypeptide binding]; other site 508765004123 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 508765004124 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 508765004125 TPP-binding site; other site 508765004126 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765004127 PYR/PP interface [polypeptide binding]; other site 508765004128 dimer interface [polypeptide binding]; other site 508765004129 TPP binding site [chemical binding]; other site 508765004130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765004131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765004132 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765004133 active site 508765004134 motif I; other site 508765004135 motif II; other site 508765004136 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765004137 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508765004138 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508765004139 metal binding site [ion binding]; metal-binding site 508765004140 dimer interface [polypeptide binding]; other site 508765004141 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 508765004142 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 508765004143 active site 508765004144 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765004145 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 508765004146 putative active site [active] 508765004147 metal binding site [ion binding]; metal-binding site 508765004148 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 508765004149 DNA binding residues [nucleotide binding] 508765004150 drug binding residues [chemical binding]; other site 508765004151 dimer interface [polypeptide binding]; other site 508765004152 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765004153 EamA-like transporter family; Region: EamA; cl01037 508765004154 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508765004155 Hexamer interface [polypeptide binding]; other site 508765004156 Hexagonal pore residue; other site 508765004157 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508765004158 putative catalytic cysteine [active] 508765004159 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 508765004160 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508765004161 dimer interface [polypeptide binding]; other site 508765004162 active site 508765004163 glycine loop; other site 508765004164 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765004165 4Fe-4S binding domain; Region: Fer4; cl02805 508765004166 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 508765004167 putative hexamer interface [polypeptide binding]; other site 508765004168 putative hexagonal pore; other site 508765004169 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 508765004170 G1 box; other site 508765004171 GTP/Mg2+ binding site [chemical binding]; other site 508765004172 Switch I region; other site 508765004173 G3 box; other site 508765004174 Switch II region; other site 508765004175 G4 box; other site 508765004176 G5 box; other site 508765004177 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 508765004178 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 508765004179 Cell division protein FtsA; Region: FtsA; cl11496 508765004180 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 508765004181 Hexamer interface [polypeptide binding]; other site 508765004182 Hexagonal pore residue; other site 508765004183 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 508765004184 Hexamer/Pentamer interface [polypeptide binding]; other site 508765004185 central pore; other site 508765004186 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508765004187 SLBB domain; Region: SLBB; pfam10531 508765004188 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 508765004189 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 508765004190 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 508765004191 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 508765004192 putative hexamer interface [polypeptide binding]; other site 508765004193 putative hexagonal pore; other site 508765004194 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 508765004195 putative hexamer interface [polypeptide binding]; other site 508765004196 putative hexagonal pore; other site 508765004197 Cupin domain; Region: Cupin_2; cl09118 508765004198 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 508765004199 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508765004200 Hexamer interface [polypeptide binding]; other site 508765004201 Hexagonal pore residue; other site 508765004202 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 508765004203 putative catalytic cysteine [active] 508765004204 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 508765004205 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765004206 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765004207 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508765004208 Hexamer interface [polypeptide binding]; other site 508765004209 Putative hexagonal pore residue; other site 508765004210 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 508765004211 octamerization interface [polypeptide binding]; other site 508765004212 diferric-oxygen binding site [ion binding]; other site 508765004213 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765004214 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004216 G4 box; other site 508765004217 G5 box; other site 508765004218 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 508765004219 4Fe-4S binding domain; Region: Fer4; cl02805 508765004220 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 508765004221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765004222 4Fe-4S binding domain; Region: Fer4; cl02805 508765004223 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 508765004224 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 508765004225 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 508765004226 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 508765004227 intersubunit interface [polypeptide binding]; other site 508765004228 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 508765004229 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765004230 ABC-ATPase subunit interface; other site 508765004231 dimer interface [polypeptide binding]; other site 508765004232 putative PBP binding regions; other site 508765004233 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765004234 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765004235 Walker A/P-loop; other site 508765004236 ATP binding site [chemical binding]; other site 508765004237 Q-loop/lid; other site 508765004238 ABC transporter signature motif; other site 508765004239 Walker B; other site 508765004240 D-loop; other site 508765004241 H-loop/switch region; other site 508765004242 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 508765004243 DEAD-like helicases superfamily; Region: DEXDc; smart00487 508765004244 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765004245 ATP binding site [chemical binding]; other site 508765004246 Mg++ binding site [ion binding]; other site 508765004247 motif III; other site 508765004248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765004249 nucleotide binding region [chemical binding]; other site 508765004250 ATP-binding site [chemical binding]; other site 508765004251 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765004252 Short C-terminal domain; Region: SHOCT; cl01373 508765004253 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 508765004254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004256 active site 508765004257 phosphorylation site [posttranslational modification] 508765004258 intermolecular recognition site; other site 508765004259 dimerization interface [polypeptide binding]; other site 508765004260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004261 DNA binding site [nucleotide binding] 508765004262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765004263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765004264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004265 dimer interface [polypeptide binding]; other site 508765004266 phosphorylation site [posttranslational modification] 508765004267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004268 ATP binding site [chemical binding]; other site 508765004269 Mg2+ binding site [ion binding]; other site 508765004270 G-X-G motif; other site 508765004271 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 508765004272 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508765004273 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 508765004274 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508765004275 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508765004276 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 508765004277 OpgC protein; Region: OpgC_C; cl00792 508765004278 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 508765004279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765004280 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004281 MatE; Region: MatE; cl10513 508765004282 MatE; Region: MatE; cl10513 508765004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004284 active site 508765004285 phosphorylation site [posttranslational modification] 508765004286 intermolecular recognition site; other site 508765004287 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 508765004288 dimerization interface [polypeptide binding]; other site 508765004289 PAS fold; Region: PAS_4; pfam08448 508765004290 PAS fold; Region: PAS_4; pfam08448 508765004291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765004292 putative active site [active] 508765004293 heme pocket [chemical binding]; other site 508765004294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765004295 metal binding site [ion binding]; metal-binding site 508765004296 active site 508765004297 I-site; other site 508765004298 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765004299 TraX protein; Region: TraX; cl05434 508765004300 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 508765004301 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 508765004302 metal binding triad [ion binding]; metal-binding site 508765004303 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 508765004304 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 508765004305 NAD binding site [chemical binding]; other site 508765004306 sugar binding site [chemical binding]; other site 508765004307 divalent metal binding site [ion binding]; other site 508765004308 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765004309 dimer interface [polypeptide binding]; other site 508765004310 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 508765004311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765004312 Walker A motif; other site 508765004313 ATP binding site [chemical binding]; other site 508765004314 Walker B motif; other site 508765004315 arginine finger; other site 508765004316 Transcriptional antiterminator [Transcription]; Region: COG3933 508765004317 PRD domain; Region: PRD; cl15445 508765004318 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765004319 active pocket/dimerization site; other site 508765004320 active site 508765004321 phosphorylation site [posttranslational modification] 508765004322 PRD domain; Region: PRD; cl15445 508765004323 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 508765004324 active site 508765004325 P-loop; other site 508765004326 phosphorylation site [posttranslational modification] 508765004327 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 508765004328 methionine cluster; other site 508765004329 active site 508765004330 phosphorylation site [posttranslational modification] 508765004331 metal binding site [ion binding]; metal-binding site 508765004332 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 508765004333 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765004334 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 508765004335 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765004336 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 508765004337 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765004338 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765004339 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 508765004340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004342 active site 508765004343 phosphorylation site [posttranslational modification] 508765004344 intermolecular recognition site; other site 508765004345 dimerization interface [polypeptide binding]; other site 508765004346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004347 DNA binding site [nucleotide binding] 508765004348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765004349 dimerization interface [polypeptide binding]; other site 508765004350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004351 dimer interface [polypeptide binding]; other site 508765004352 phosphorylation site [posttranslational modification] 508765004353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004354 ATP binding site [chemical binding]; other site 508765004355 Mg2+ binding site [ion binding]; other site 508765004356 G-X-G motif; other site 508765004357 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 508765004358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004360 putative substrate translocation pore; other site 508765004361 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 508765004362 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 508765004363 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765004364 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 508765004365 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765004366 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765004367 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765004368 Helix-turn-helix domains; Region: HTH; cl00088 508765004369 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765004370 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765004371 4Fe-4S binding domain; Region: Fer4; cl02805 508765004372 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 508765004373 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508765004374 dimer interface [polypeptide binding]; other site 508765004375 active site 508765004376 glycine loop; other site 508765004377 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508765004378 active site 508765004379 intersubunit interactions; other site 508765004380 catalytic residue [active] 508765004381 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 508765004382 DNA-binding site [nucleotide binding]; DNA binding site 508765004383 RNA-binding motif; other site 508765004384 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 508765004385 MatE; Region: MatE; cl10513 508765004386 MatE; Region: MatE; cl10513 508765004387 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 508765004388 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765004389 active site turn [active] 508765004390 phosphorylation site [posttranslational modification] 508765004391 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765004392 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 508765004393 HPr interaction site; other site 508765004394 glycerol kinase (GK) interaction site [polypeptide binding]; other site 508765004395 active site 508765004396 phosphorylation site [posttranslational modification] 508765004397 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 508765004398 transcriptional antiterminator BglG; Provisional; Region: PRK09772 508765004399 CAT RNA binding domain; Region: CAT_RBD; cl03904 508765004400 PRD domain; Region: PRD; cl15445 508765004401 PRD domain; Region: PRD; cl15445 508765004402 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 508765004403 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 508765004404 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765004405 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765004406 NodB motif; other site 508765004407 active site 508765004408 catalytic site [active] 508765004409 Zn binding site [ion binding]; other site 508765004410 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765004411 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 508765004412 substrate binding site [chemical binding]; other site 508765004413 dimer interface [polypeptide binding]; other site 508765004414 ATP binding site [chemical binding]; other site 508765004415 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 508765004416 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 508765004417 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 508765004418 Walker A/P-loop; other site 508765004419 ATP binding site [chemical binding]; other site 508765004420 Q-loop/lid; other site 508765004421 ABC transporter signature motif; other site 508765004422 Walker B; other site 508765004423 D-loop; other site 508765004424 H-loop/switch region; other site 508765004425 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 508765004426 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 508765004427 TM-ABC transporter signature motif; other site 508765004428 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 508765004429 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 508765004430 ligand binding site [chemical binding]; other site 508765004431 dimerization interface [polypeptide binding]; other site 508765004432 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765004433 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765004434 DNA binding site [nucleotide binding] 508765004435 domain linker motif; other site 508765004436 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765004437 dimerization interface [polypeptide binding]; other site 508765004438 ligand binding site [chemical binding]; other site 508765004439 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 508765004440 putative active site pocket [active] 508765004441 dimerization interface [polypeptide binding]; other site 508765004442 putative catalytic residue [active] 508765004443 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 508765004444 putative substrate binding pocket [chemical binding]; other site 508765004445 AC domain interface; other site 508765004446 catalytic triad [active] 508765004447 AB domain interface; other site 508765004448 interchain disulfide; other site 508765004449 Protein of unknown function (DUF979); Region: DUF979; cl01572 508765004450 Protein of unknown function (DUF969); Region: DUF969; cl01573 508765004451 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 508765004452 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 508765004453 NAD binding site [chemical binding]; other site 508765004454 substrate binding site [chemical binding]; other site 508765004455 active site 508765004456 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 508765004457 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765004458 inhibitor-cofactor binding pocket; inhibition site 508765004459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004460 catalytic residue [active] 508765004461 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 508765004462 ligand binding site; other site 508765004463 tetramer interface; other site 508765004464 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765004465 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765004466 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765004467 Helix-turn-helix domains; Region: HTH; cl00088 508765004468 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765004469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 508765004470 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 508765004471 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 508765004472 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 508765004473 Substrate binding site; other site 508765004474 metal-binding site 508765004475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765004476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765004477 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 508765004478 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508765004479 active site 508765004480 homodimer interface [polypeptide binding]; other site 508765004481 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 508765004482 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765004483 A-macroglobulin receptor; Region: A2M_recep; pfam07677 508765004484 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 508765004485 NeuB family; Region: NeuB; cl00496 508765004486 SAF domain; Region: SAF; cl00555 508765004487 Protein of unknown function, DUF606; Region: DUF606; cl01273 508765004488 Protein of unknown function, DUF606; Region: DUF606; cl01273 508765004489 Membrane protein of unknown function; Region: DUF360; cl00850 508765004490 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 508765004491 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765004492 ligand binding site [chemical binding]; other site 508765004493 flexible hinge region; other site 508765004494 Helix-turn-helix domains; Region: HTH; cl00088 508765004495 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 508765004496 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 508765004497 yybP-ykoY leader 508765004498 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508765004499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765004500 FeS/SAM binding site; other site 508765004501 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 508765004502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004503 Response regulator receiver domain; Region: Response_reg; pfam00072 508765004504 active site 508765004505 phosphorylation site [posttranslational modification] 508765004506 intermolecular recognition site; other site 508765004507 dimerization interface [polypeptide binding]; other site 508765004508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765004509 S-adenosylmethionine binding site [chemical binding]; other site 508765004510 Cupin domain; Region: Cupin_2; cl09118 508765004511 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 508765004512 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508765004513 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765004514 synthetase active site [active] 508765004515 NTP binding site [chemical binding]; other site 508765004516 metal binding site [ion binding]; metal-binding site 508765004517 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 508765004518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765004519 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508765004520 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508765004521 dimer interface [polypeptide binding]; other site 508765004522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004523 catalytic residue [active] 508765004524 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004525 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004526 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 508765004527 alanine racemase; Reviewed; Region: alr; PRK00053 508765004528 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 508765004529 active site 508765004530 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765004531 dimer interface [polypeptide binding]; other site 508765004532 substrate binding site [chemical binding]; other site 508765004533 catalytic residues [active] 508765004534 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 508765004535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765004536 DNA-binding site [nucleotide binding]; DNA binding site 508765004537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765004538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004539 homodimer interface [polypeptide binding]; other site 508765004540 catalytic residue [active] 508765004541 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004542 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765004543 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 508765004544 Protein of unknown function (DUF503); Region: DUF503; cl00669 508765004545 Predicted membrane protein [Function unknown]; Region: COG4129 508765004546 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 508765004547 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 508765004548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765004549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765004550 DNA-binding site [nucleotide binding]; DNA binding site 508765004551 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508765004552 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508765004553 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 508765004554 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 508765004555 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 508765004556 Sulfatase; Region: Sulfatase; cl10460 508765004557 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 508765004558 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508765004559 TPP-binding site [chemical binding]; other site 508765004560 dimer interface [polypeptide binding]; other site 508765004561 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508765004562 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508765004563 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 508765004564 active site 508765004565 intersubunit interactions; other site 508765004566 catalytic residue [active] 508765004567 Predicted membrane protein [Function unknown]; Region: COG1511 508765004568 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508765004569 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765004570 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004571 MatE; Region: MatE; cl10513 508765004572 MatE; Region: MatE; cl10513 508765004573 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 508765004574 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765004575 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 508765004576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004577 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 508765004578 Dynamin family; Region: Dynamin_N; pfam00350 508765004579 G1 box; other site 508765004580 G1 box; other site 508765004581 GTP/Mg2+ binding site [chemical binding]; other site 508765004582 GTP/Mg2+ binding site [chemical binding]; other site 508765004583 G2 box; other site 508765004584 Switch I region; other site 508765004585 G3 box; other site 508765004586 Switch II region; other site 508765004587 G4 box; other site 508765004588 G5 box; other site 508765004589 Dynamin family; Region: Dynamin_N; pfam00350 508765004590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004591 GTP/Mg2+ binding site [chemical binding]; other site 508765004592 G1 box; other site 508765004593 G2 box; other site 508765004594 Switch I region; other site 508765004595 G3 box; other site 508765004596 Switch II region; other site 508765004597 G4 box; other site 508765004598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004599 G1 box; other site 508765004600 GTP/Mg2+ binding site [chemical binding]; other site 508765004601 G2 box; other site 508765004602 Switch I region; other site 508765004603 G3 box; other site 508765004604 Switch II region; other site 508765004605 G4 box; other site 508765004606 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 508765004607 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765004608 inhibitor-cofactor binding pocket; inhibition site 508765004609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765004610 catalytic residue [active] 508765004611 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508765004612 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 508765004613 DNA binding residues [nucleotide binding] 508765004614 dimer interface [polypeptide binding]; other site 508765004615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765004616 S-adenosylmethionine binding site [chemical binding]; other site 508765004617 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508765004618 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 508765004619 HSP70 interaction site [polypeptide binding]; other site 508765004620 antheraxanthin epoxidase/zeaxanthin epoxidase; Region: PLN02927 508765004621 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 508765004622 phosphopeptide binding site; other site 508765004623 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 508765004624 active site 508765004625 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 508765004626 active site 508765004627 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 508765004628 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508765004629 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508765004630 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 508765004631 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765004632 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765004633 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 508765004634 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 508765004635 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 508765004636 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 508765004637 RHS Repeat; Region: RHS_repeat; cl11982 508765004638 RHS Repeat; Region: RHS_repeat; cl11982 508765004639 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004640 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004641 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 508765004642 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004643 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508765004644 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 508765004645 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 508765004646 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 508765004647 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508765004648 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 508765004649 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765004650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765004651 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 508765004652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765004653 non-specific DNA binding site [nucleotide binding]; other site 508765004654 salt bridge; other site 508765004655 sequence-specific DNA binding site [nucleotide binding]; other site 508765004656 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 508765004657 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 508765004658 Hsp70 protein; Region: HSP70; pfam00012 508765004659 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 508765004660 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765004661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004662 binding surface 508765004663 TPR motif; other site 508765004664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004665 binding surface 508765004666 TPR motif; other site 508765004667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004668 binding surface 508765004669 TPR motif; other site 508765004670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004671 binding surface 508765004672 TPR motif; other site 508765004673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004674 binding surface 508765004675 TPR motif; other site 508765004676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004677 binding surface 508765004678 TPR motif; other site 508765004679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765004680 binding surface 508765004681 TPR motif; other site 508765004682 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765004683 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765004684 nudix motif; other site 508765004685 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 508765004686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765004687 active site 508765004688 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 508765004689 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 508765004690 active site 508765004691 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 508765004692 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765004693 active site 508765004694 catalytic triad [active] 508765004695 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765004696 active site 508765004697 catalytic triad [active] 508765004698 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 508765004699 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 508765004700 NAD(P) binding site [chemical binding]; other site 508765004701 catalytic residues [active] 508765004702 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 508765004703 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl15791 508765004704 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765004705 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765004706 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 508765004707 nudix motif; other site 508765004708 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004709 MatE; Region: MatE; cl10513 508765004710 MatE; Region: MatE; cl10513 508765004711 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765004712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765004713 DNA-binding site [nucleotide binding]; DNA binding site 508765004714 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765004715 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 508765004716 Walker A/P-loop; other site 508765004717 ATP binding site [chemical binding]; other site 508765004718 Q-loop/lid; other site 508765004719 ABC transporter signature motif; other site 508765004720 Walker B; other site 508765004721 D-loop; other site 508765004722 H-loop/switch region; other site 508765004723 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765004724 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765004725 RNA binding surface [nucleotide binding]; other site 508765004726 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 508765004727 active site 508765004728 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508765004729 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508765004730 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508765004731 putative active site [active] 508765004732 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 508765004733 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 508765004734 active site 508765004735 NTP binding site [chemical binding]; other site 508765004736 metal binding triad [ion binding]; metal-binding site 508765004737 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 508765004738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765004739 Late competence development protein ComFB; Region: ComFB; pfam10719 508765004740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004742 active site 508765004743 phosphorylation site [posttranslational modification] 508765004744 intermolecular recognition site; other site 508765004745 dimerization interface [polypeptide binding]; other site 508765004746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004747 DNA binding site [nucleotide binding] 508765004748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004749 dimer interface [polypeptide binding]; other site 508765004750 phosphorylation site [posttranslational modification] 508765004751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004752 ATP binding site [chemical binding]; other site 508765004753 Mg2+ binding site [ion binding]; other site 508765004754 G-X-G motif; other site 508765004755 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765004756 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 508765004757 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 508765004758 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 508765004759 DNA topoisomerase III; Provisional; Region: PRK07726 508765004760 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 508765004761 active site 508765004762 putative interdomain interaction site [polypeptide binding]; other site 508765004763 putative metal-binding site [ion binding]; other site 508765004764 putative nucleotide binding site [chemical binding]; other site 508765004765 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 508765004766 domain I; other site 508765004767 DNA binding groove [nucleotide binding] 508765004768 phosphate binding site [ion binding]; other site 508765004769 domain II; other site 508765004770 domain III; other site 508765004771 nucleotide binding site [chemical binding]; other site 508765004772 catalytic site [active] 508765004773 domain IV; other site 508765004774 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508765004775 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 508765004776 active site 508765004777 substrate binding site [chemical binding]; other site 508765004778 catalytic site [active] 508765004779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004781 putative efflux protein, MATE family; Region: matE; TIGR00797 508765004782 MatE; Region: MatE; cl10513 508765004783 MatE; Region: MatE; cl10513 508765004784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004786 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 508765004787 xanthine permease; Region: pbuX; TIGR03173 508765004788 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 508765004789 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 508765004790 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765004791 MatE; Region: MatE; cl10513 508765004792 MatE; Region: MatE; cl10513 508765004793 pyruvate carboxylase; Reviewed; Region: PRK12999 508765004794 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 508765004795 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765004796 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 508765004797 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 508765004798 active site 508765004799 catalytic residues [active] 508765004800 metal binding site [ion binding]; metal-binding site 508765004801 homodimer binding site [polypeptide binding]; other site 508765004802 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 508765004803 carboxyltransferase (CT) interaction site; other site 508765004804 biotinylation site [posttranslational modification]; other site 508765004805 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 508765004806 carbohydrate binding site [chemical binding]; other site 508765004807 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 508765004808 carbohydrate binding site [chemical binding]; other site 508765004809 pullulanase, type I; Region: pulA_typeI; TIGR02104 508765004810 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 508765004811 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 508765004812 Ca binding site [ion binding]; other site 508765004813 active site 508765004814 catalytic site [active] 508765004815 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 508765004816 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 508765004817 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 508765004818 active site 508765004819 putative substrate binding pocket [chemical binding]; other site 508765004820 T-box leader 508765004821 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 508765004822 active site 508765004823 HIGH motif; other site 508765004824 dimer interface [polypeptide binding]; other site 508765004825 KMSKS motif; other site 508765004826 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508765004827 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 508765004828 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 508765004829 DNA binding site [nucleotide binding] 508765004830 active site 508765004831 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 508765004832 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765004833 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765004834 synthetase active site [active] 508765004835 NTP binding site [chemical binding]; other site 508765004836 metal binding site [ion binding]; metal-binding site 508765004837 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 508765004838 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 508765004839 NAD binding site [chemical binding]; other site 508765004840 homodimer interface [polypeptide binding]; other site 508765004841 active site 508765004842 substrate binding site [chemical binding]; other site 508765004843 PreQ1 riboswitch 508765004844 QueT transporter; Region: QueT; cl01932 508765004845 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 508765004846 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 508765004847 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 508765004848 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 508765004849 DXD motif; other site 508765004850 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 508765004851 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 508765004852 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 508765004853 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765004854 dimer interface [polypeptide binding]; other site 508765004855 putative CheW interface [polypeptide binding]; other site 508765004856 Sensory domain found in PocR; Region: PocR; pfam10114 508765004857 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765004858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 508765004859 DNA binding residues [nucleotide binding] 508765004860 dimerization interface [polypeptide binding]; other site 508765004861 Response regulator receiver domain; Region: Response_reg; pfam00072 508765004862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004863 active site 508765004864 phosphorylation site [posttranslational modification] 508765004865 intermolecular recognition site; other site 508765004866 dimerization interface [polypeptide binding]; other site 508765004867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765004868 Zn2+ binding site [ion binding]; other site 508765004869 Mg2+ binding site [ion binding]; other site 508765004870 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 508765004871 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 508765004872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765004873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765004874 putative substrate translocation pore; other site 508765004875 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765004876 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 508765004877 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765004878 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 508765004879 hypothetical protein; Provisional; Region: PRK00955 508765004880 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 508765004881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765004882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765004883 dimer interface [polypeptide binding]; other site 508765004884 putative CheW interface [polypeptide binding]; other site 508765004885 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 508765004886 active site 508765004887 DNA binding site [nucleotide binding] 508765004888 putative phosphate binding site [ion binding]; other site 508765004889 putative catalytic site [active] 508765004890 metal binding site A [ion binding]; metal-binding site 508765004891 AP binding site [nucleotide binding]; other site 508765004892 metal binding site B [ion binding]; metal-binding site 508765004893 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508765004894 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765004895 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765004896 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 508765004897 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 508765004898 G1 box; other site 508765004899 putative GEF interaction site [polypeptide binding]; other site 508765004900 GTP/Mg2+ binding site [chemical binding]; other site 508765004901 Switch I region; other site 508765004902 G2 box; other site 508765004903 G3 box; other site 508765004904 Switch II region; other site 508765004905 G4 box; other site 508765004906 G5 box; other site 508765004907 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 508765004908 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 508765004909 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 508765004910 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508765004911 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 508765004912 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765004913 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 508765004914 active site 508765004915 NAD binding site [chemical binding]; other site 508765004916 metal binding site [ion binding]; metal-binding site 508765004917 propanediol utilization protein PduB; Provisional; Region: PRK15415 508765004918 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 508765004919 putative hexamer interface [polypeptide binding]; other site 508765004920 putative hexagonal pore; other site 508765004921 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 508765004922 putative hexamer interface [polypeptide binding]; other site 508765004923 putative hexagonal pore; other site 508765004924 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 508765004925 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 508765004926 Hexamer interface [polypeptide binding]; other site 508765004927 Hexagonal pore residue; other site 508765004928 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508765004929 Hexamer interface [polypeptide binding]; other site 508765004930 Putative hexagonal pore residue; other site 508765004931 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 508765004932 Hexamer interface [polypeptide binding]; other site 508765004933 Putative hexagonal pore residue; other site 508765004934 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 508765004935 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765004936 Propanediol utilisation protein PduL; Region: PduL; pfam06130 508765004937 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 508765004938 Flavoprotein; Region: Flavoprotein; cl08021 508765004939 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 508765004940 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 508765004941 Hexamer/Pentamer interface [polypeptide binding]; other site 508765004942 central pore; other site 508765004943 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 508765004944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 508765004945 putative catalytic cysteine [active] 508765004946 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508765004947 SLBB domain; Region: SLBB; pfam10531 508765004948 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 508765004949 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 508765004950 ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526 508765004951 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 508765004952 putative hexamer interface [polypeptide binding]; other site 508765004953 putative hexagonal pore; other site 508765004954 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 508765004955 putative hexamer interface [polypeptide binding]; other site 508765004956 putative hexagonal pore; other site 508765004957 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 508765004958 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 508765004959 DHHA1 domain; Region: DHHA1; pfam02272 508765004960 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 508765004961 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 508765004962 putative homotetramer interface [polypeptide binding]; other site 508765004963 putative homodimer interface [polypeptide binding]; other site 508765004964 putative allosteric switch controlling residues; other site 508765004965 putative metal binding site [ion binding]; other site 508765004966 putative homodimer-homodimer interface [polypeptide binding]; other site 508765004967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765004969 active site 508765004970 phosphorylation site [posttranslational modification] 508765004971 intermolecular recognition site; other site 508765004972 dimerization interface [polypeptide binding]; other site 508765004973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765004974 DNA binding site [nucleotide binding] 508765004975 OPT oligopeptide transporter protein; Region: OPT; cl14607 508765004976 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 508765004977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765004978 dimer interface [polypeptide binding]; other site 508765004979 phosphorylation site [posttranslational modification] 508765004980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765004981 ATP binding site [chemical binding]; other site 508765004982 Mg2+ binding site [ion binding]; other site 508765004983 G-X-G motif; other site 508765004984 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 508765004985 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 508765004986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765004987 NlpC/P60 family; Region: NLPC_P60; cl11438 508765004988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765004989 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765004990 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765004991 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 508765004992 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 508765004993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765004994 AAA domain; Region: AAA_18; pfam13238 508765004995 Shikimate kinase; Region: SKI; pfam01202 508765004996 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508765004997 putative active site [active] 508765004998 hypothetical protein; Provisional; Region: PRK11770 508765004999 Domain of unknown function (DUF307); Region: DUF307; pfam03733 508765005000 Domain of unknown function (DUF307); Region: DUF307; pfam03733 508765005001 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 508765005002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 508765005003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 508765005004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765005005 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 508765005006 Walker A/P-loop; other site 508765005007 ATP binding site [chemical binding]; other site 508765005008 Q-loop/lid; other site 508765005009 ABC transporter signature motif; other site 508765005010 Walker B; other site 508765005011 D-loop; other site 508765005012 H-loop/switch region; other site 508765005013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005015 active site 508765005016 phosphorylation site [posttranslational modification] 508765005017 intermolecular recognition site; other site 508765005018 dimerization interface [polypeptide binding]; other site 508765005019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005020 DNA binding site [nucleotide binding] 508765005021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005022 dimer interface [polypeptide binding]; other site 508765005023 phosphorylation site [posttranslational modification] 508765005024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005025 ATP binding site [chemical binding]; other site 508765005026 Mg2+ binding site [ion binding]; other site 508765005027 G-X-G motif; other site 508765005028 TraX protein; Region: TraX; cl05434 508765005029 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508765005030 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508765005031 G1 box; other site 508765005032 GTP/Mg2+ binding site [chemical binding]; other site 508765005033 Switch I region; other site 508765005034 G2 box; other site 508765005035 G3 box; other site 508765005036 Switch II region; other site 508765005037 G4 box; other site 508765005038 G5 box; other site 508765005039 Nucleoside recognition; Region: Gate; cl00486 508765005040 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508765005041 Nucleoside recognition; Region: Gate; cl00486 508765005042 FeoA domain; Region: FeoA; cl00838 508765005043 manganese transport transcriptional regulator; Provisional; Region: PRK03902 508765005044 Helix-turn-helix domains; Region: HTH; cl00088 508765005045 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 508765005046 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005047 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005048 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 508765005049 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 508765005050 starch-binding site 2 [chemical binding]; other site 508765005051 starch-binding site 1 [chemical binding]; other site 508765005052 Protein of unknown function, DUF488; Region: DUF488; cl01246 508765005053 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 508765005054 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 508765005055 PHP-associated; Region: PHP_C; pfam13263 508765005056 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 508765005057 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 508765005058 putative active site [active] 508765005059 putative CoA binding site [chemical binding]; other site 508765005060 nudix motif; other site 508765005061 metal binding site [ion binding]; metal-binding site 508765005062 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765005063 metal-binding site [ion binding] 508765005064 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 508765005065 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 508765005066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 508765005067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765005068 Walker A motif; other site 508765005069 ATP binding site [chemical binding]; other site 508765005070 Walker B motif; other site 508765005071 arginine finger; other site 508765005072 Helix-turn-helix domains; Region: HTH; cl00088 508765005073 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 508765005074 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508765005075 tetramer interface [polypeptide binding]; other site 508765005076 catalytic Zn binding site [ion binding]; other site 508765005077 NADP binding site [chemical binding]; other site 508765005078 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 508765005079 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 508765005080 Sodium:solute symporter family; Region: SSF; cl00456 508765005081 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 508765005082 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 508765005083 HI0933-like protein; Region: HI0933_like; pfam03486 508765005084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765005085 cytidylate kinase; Provisional; Region: cmk; PRK00023 508765005086 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 508765005087 CMP-binding site; other site 508765005088 The sites determining sugar specificity; other site 508765005089 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 508765005090 LytB protein; Region: LYTB; cl00507 508765005091 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 508765005092 RNA binding site [nucleotide binding]; other site 508765005093 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 508765005094 RNA binding site [nucleotide binding]; other site 508765005095 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 508765005096 RNA binding site [nucleotide binding]; other site 508765005097 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 508765005098 RNA binding site [nucleotide binding]; other site 508765005099 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005100 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 508765005101 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 508765005102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005103 FeS/SAM binding site; other site 508765005104 TRAM domain; Region: TRAM; cl01282 508765005105 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 508765005106 putative deacylase active site [active] 508765005107 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 508765005108 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765005109 DNA binding site [nucleotide binding] 508765005110 Int/Topo IB signature motif; other site 508765005111 active site 508765005112 LexA repressor; Validated; Region: PRK00215 508765005113 Helix-turn-helix domains; Region: HTH; cl00088 508765005114 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 508765005115 Catalytic site [active] 508765005116 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 508765005117 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765005118 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 508765005119 Sm1 motif; other site 508765005120 intra - hexamer interaction site; other site 508765005121 inter - hexamer interaction site [polypeptide binding]; other site 508765005122 nucleotide binding pocket [chemical binding]; other site 508765005123 Sm2 motif; other site 508765005124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765005125 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 508765005126 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 508765005127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005128 ATP binding site [chemical binding]; other site 508765005129 Mg2+ binding site [ion binding]; other site 508765005130 G-X-G motif; other site 508765005131 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 508765005132 ATP binding site [chemical binding]; other site 508765005133 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 508765005134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765005135 DNA-binding site [nucleotide binding]; DNA binding site 508765005136 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 508765005137 UTRA domain; Region: UTRA; cl01230 508765005138 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765005139 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765005140 Ca binding site [ion binding]; other site 508765005141 active site 508765005142 catalytic site [active] 508765005143 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 508765005144 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765005145 active site turn [active] 508765005146 phosphorylation site [posttranslational modification] 508765005147 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765005148 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 508765005149 MutS domain I; Region: MutS_I; pfam01624 508765005150 MutS domain II; Region: MutS_II; pfam05188 508765005151 MutS family domain IV; Region: MutS_IV; pfam05190 508765005152 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 508765005153 Walker A/P-loop; other site 508765005154 ATP binding site [chemical binding]; other site 508765005155 Q-loop/lid; other site 508765005156 ABC transporter signature motif; other site 508765005157 Walker B; other site 508765005158 D-loop; other site 508765005159 H-loop/switch region; other site 508765005160 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 508765005161 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 508765005162 Radical SAM superfamily; Region: Radical_SAM; pfam04055 508765005163 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508765005164 MgtC family; Region: MgtC; pfam02308 508765005165 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 508765005166 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 508765005167 active site 508765005168 catalytic site [active] 508765005169 metal binding site [ion binding]; metal-binding site 508765005170 dimer interface [polypeptide binding]; other site 508765005171 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 508765005172 MgtC family; Region: MgtC; pfam02308 508765005173 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 508765005174 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 508765005175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765005176 ATP binding site [chemical binding]; other site 508765005177 putative Mg++ binding site [ion binding]; other site 508765005178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765005179 nucleotide binding region [chemical binding]; other site 508765005180 ATP-binding site [chemical binding]; other site 508765005181 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765005182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765005183 Walker A/P-loop; other site 508765005184 ATP binding site [chemical binding]; other site 508765005185 Q-loop/lid; other site 508765005186 ABC transporter signature motif; other site 508765005187 Walker B; other site 508765005188 D-loop; other site 508765005189 H-loop/switch region; other site 508765005190 ABC transporter; Region: ABC_tran_2; pfam12848 508765005191 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765005192 phytoene desaturase; Region: crtI_fam; TIGR02734 508765005193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765005194 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 508765005195 NlpC/P60 family; Region: NLPC_P60; cl11438 508765005196 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 508765005197 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 508765005198 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 508765005199 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 508765005200 nudix motif; other site 508765005201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765005202 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 508765005203 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 508765005204 active site 508765005205 metal binding site [ion binding]; metal-binding site 508765005206 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508765005207 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 508765005208 4Fe-4S binding domain; Region: Fer4; cl02805 508765005209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005210 FeS/SAM binding site; other site 508765005211 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 508765005212 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 508765005213 dimer interface [polypeptide binding]; other site 508765005214 active site 508765005215 glycine loop; other site 508765005216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 508765005217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005218 active site 508765005219 phosphorylation site [posttranslational modification] 508765005220 intermolecular recognition site; other site 508765005221 dimerization interface [polypeptide binding]; other site 508765005222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005225 Sensory domain found in PocR; Region: PocR; pfam10114 508765005226 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765005227 Histidine kinase; Region: His_kinase; pfam06580 508765005228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005229 ATP binding site [chemical binding]; other site 508765005230 G-X-G motif; other site 508765005231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508765005232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508765005233 active site 508765005234 catalytic tetrad [active] 508765005235 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 508765005236 Cation transport protein; Region: TrkH; cl10514 508765005237 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 508765005238 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 508765005239 active site 508765005240 Zn binding site [ion binding]; other site 508765005241 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 508765005242 octamerization interface [polypeptide binding]; other site 508765005243 diferric-oxygen binding site [ion binding]; other site 508765005244 Sel1 repeat; Region: Sel1; cl02723 508765005245 Sel1 repeat; Region: Sel1; cl02723 508765005246 Sel1 repeat; Region: Sel1; cl02723 508765005247 Sel1 repeat; Region: Sel1; cl02723 508765005248 Sel1 repeat; Region: Sel1; cl02723 508765005249 Sel1 repeat; Region: Sel1; cl02723 508765005250 Predicted Ser/Thr protein kinase [Signal transduction mechanisms]; Region: COG2112 508765005251 PAS domain S-box; Region: sensory_box; TIGR00229 508765005252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 508765005253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005254 dimer interface [polypeptide binding]; other site 508765005255 phosphorylation site [posttranslational modification] 508765005256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005257 ATP binding site [chemical binding]; other site 508765005258 Mg2+ binding site [ion binding]; other site 508765005259 G-X-G motif; other site 508765005260 PAS domain S-box; Region: sensory_box; TIGR00229 508765005261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 508765005262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005263 dimer interface [polypeptide binding]; other site 508765005264 phosphorylation site [posttranslational modification] 508765005265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005266 ATP binding site [chemical binding]; other site 508765005267 Mg2+ binding site [ion binding]; other site 508765005268 G-X-G motif; other site 508765005269 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 508765005270 Amino acid permease; Region: AA_permease_2; pfam13520 508765005271 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 508765005272 Cache domain; Region: Cache_1; pfam02743 508765005273 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 508765005274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765005275 dimerization interface [polypeptide binding]; other site 508765005276 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765005277 dimer interface [polypeptide binding]; other site 508765005278 putative CheW interface [polypeptide binding]; other site 508765005279 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 508765005280 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 508765005281 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 508765005282 DNA binding residues [nucleotide binding] 508765005283 dimer interface [polypeptide binding]; other site 508765005284 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 508765005285 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 508765005286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005287 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765005288 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 508765005289 active site residue [active] 508765005290 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 508765005291 CPxP motif; other site 508765005292 DsrE/DsrF-like family; Region: DrsE; cl00672 508765005293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005295 active site 508765005296 phosphorylation site [posttranslational modification] 508765005297 intermolecular recognition site; other site 508765005298 dimerization interface [polypeptide binding]; other site 508765005299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005300 DNA binding site [nucleotide binding] 508765005301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005302 dimer interface [polypeptide binding]; other site 508765005303 phosphorylation site [posttranslational modification] 508765005304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005305 ATP binding site [chemical binding]; other site 508765005306 Mg2+ binding site [ion binding]; other site 508765005307 G-X-G motif; other site 508765005308 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 508765005309 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765005310 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765005311 Walker A/P-loop; other site 508765005312 ATP binding site [chemical binding]; other site 508765005313 Q-loop/lid; other site 508765005314 ABC transporter signature motif; other site 508765005315 Walker B; other site 508765005316 D-loop; other site 508765005317 H-loop/switch region; other site 508765005318 FtsX-like permease family; Region: FtsX; cl15850 508765005319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 508765005320 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005321 dimer interface [polypeptide binding]; other site 508765005322 phosphorylation site [posttranslational modification] 508765005323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005324 ATP binding site [chemical binding]; other site 508765005325 Mg2+ binding site [ion binding]; other site 508765005326 G-X-G motif; other site 508765005327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 508765005328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765005329 dimer interface [polypeptide binding]; other site 508765005330 phosphorylation site [posttranslational modification] 508765005331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005332 ATP binding site [chemical binding]; other site 508765005333 Mg2+ binding site [ion binding]; other site 508765005334 G-X-G motif; other site 508765005335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765005336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005337 active site 508765005338 phosphorylation site [posttranslational modification] 508765005339 intermolecular recognition site; other site 508765005340 dimerization interface [polypeptide binding]; other site 508765005341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765005342 DNA binding site [nucleotide binding] 508765005343 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 508765005344 MgtE intracellular N domain; Region: MgtE_N; cl15244 508765005345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 508765005346 Divalent cation transporter; Region: MgtE; cl00786 508765005347 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 508765005348 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765005349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765005350 motif II; other site 508765005351 hybrid cluster protein; Provisional; Region: PRK05290 508765005352 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765005353 ACS interaction site; other site 508765005354 CODH interaction site; other site 508765005355 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 508765005356 hybrid metal cluster; other site 508765005357 TPR repeat; Region: TPR_11; pfam13414 508765005358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765005359 binding surface 508765005360 TPR motif; other site 508765005361 tetratricopeptide repeat protein; Provisional; Region: PRK11788 508765005362 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 508765005363 dinuclear metal binding motif [ion binding]; other site 508765005364 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 508765005365 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005366 Sterol carrier protein domain; Region: SCP2_2; pfam13530 508765005367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765005368 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765005369 putative substrate translocation pore; other site 508765005370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508765005371 Helix-turn-helix domains; Region: HTH; cl00088 508765005372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 508765005373 dimerization interface [polypeptide binding]; other site 508765005374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765005375 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765005376 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005377 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005378 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005379 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005380 YmaF family; Region: YmaF; pfam12788 508765005381 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765005382 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005383 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765005384 catalytic residue [active] 508765005385 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 508765005386 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 508765005387 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 508765005388 Baseplate J-like protein; Region: Baseplate_J; cl01294 508765005389 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 508765005390 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 508765005391 NlpC/P60 family; Region: NLPC_P60; cl11438 508765005392 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765005393 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 508765005394 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 508765005395 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 508765005396 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 508765005397 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 508765005398 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 508765005399 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508765005400 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508765005401 catalytic residues [active] 508765005402 catalytic nucleophile [active] 508765005403 Presynaptic Site I dimer interface [polypeptide binding]; other site 508765005404 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508765005405 Synaptic Flat tetramer interface [polypeptide binding]; other site 508765005406 Synaptic Site I dimer interface [polypeptide binding]; other site 508765005407 DNA binding site [nucleotide binding] 508765005408 Helix-turn-helix domains; Region: HTH; cl00088 508765005409 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 508765005410 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 508765005411 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765005412 dimer interface [polypeptide binding]; other site 508765005413 ssDNA binding site [nucleotide binding]; other site 508765005414 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765005415 Recombination protein U; Region: RecU; cl01314 508765005416 DnaA N-terminal domain; Region: DnaA_N; pfam11638 508765005417 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 508765005418 ERF superfamily; Region: ERF; pfam04404 508765005419 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765005420 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 508765005421 ORF6N domain; Region: ORF6N; pfam10543 508765005422 ORF6C domain; Region: ORF6C; pfam10552 508765005423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005424 non-specific DNA binding site [nucleotide binding]; other site 508765005425 salt bridge; other site 508765005426 sequence-specific DNA binding site [nucleotide binding]; other site 508765005427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005428 non-specific DNA binding site [nucleotide binding]; other site 508765005429 salt bridge; other site 508765005430 sequence-specific DNA binding site [nucleotide binding]; other site 508765005431 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765005432 DNA binding site [nucleotide binding] 508765005433 Int/Topo IB signature motif; other site 508765005434 active site 508765005435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765005436 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 508765005437 Protein of unknown function (DUF434); Region: DUF434; cl04460 508765005438 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 508765005439 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 508765005440 putative catalytic site [active] 508765005441 putative metal binding site [ion binding]; other site 508765005442 putative phosphate binding site [ion binding]; other site 508765005443 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 508765005444 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 508765005445 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 508765005446 putative active site [active] 508765005447 putative NTP binding site [chemical binding]; other site 508765005448 putative nucleic acid binding site [nucleotide binding]; other site 508765005449 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765005450 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 508765005451 Helix-turn-helix domains; Region: HTH; cl00088 508765005452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765005453 dimerization interface [polypeptide binding]; other site 508765005454 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765005455 dimer interface [polypeptide binding]; other site 508765005456 putative CheW interface [polypeptide binding]; other site 508765005457 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 508765005458 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 508765005459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765005460 catalytic residue [active] 508765005461 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 508765005462 Family description; Region: UvrD_C_2; cl15862 508765005463 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 508765005464 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 508765005465 PhnA protein; Region: PhnA; pfam03831 508765005466 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765005467 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765005468 ligand binding site [chemical binding]; other site 508765005469 flexible hinge region; other site 508765005470 Helix-turn-helix domains; Region: HTH; cl00088 508765005471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765005472 Helix-turn-helix domains; Region: HTH; cl00088 508765005473 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 508765005474 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 508765005475 putative active site [active] 508765005476 putative FMN binding site [chemical binding]; other site 508765005477 putative substrate binding site [chemical binding]; other site 508765005478 putative catalytic residue [active] 508765005479 putative 4Fe-4S cluster binding site [ion binding]; other site 508765005480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005481 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005482 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 508765005483 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 508765005484 Ligand Binding Site [chemical binding]; other site 508765005485 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 508765005486 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765005487 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765005488 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508765005489 active site residue [active] 508765005490 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 508765005491 active site residue [active] 508765005492 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765005493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765005494 binding surface 508765005495 TPR motif; other site 508765005496 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765005497 Helix-turn-helix domains; Region: HTH; cl00088 508765005498 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 508765005499 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 508765005500 FAD binding site [chemical binding]; other site 508765005501 homotetramer interface [polypeptide binding]; other site 508765005502 substrate binding pocket [chemical binding]; other site 508765005503 catalytic base [active] 508765005504 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 508765005505 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765005506 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765005507 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 508765005508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 508765005509 substrate binding site [chemical binding]; other site 508765005510 oxyanion hole (OAH) forming residues; other site 508765005511 trimer interface [polypeptide binding]; other site 508765005512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765005513 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 508765005514 Helix-turn-helix domains; Region: HTH; cl00088 508765005515 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 508765005516 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 508765005517 maltose O-acetyltransferase; Provisional; Region: PRK10092 508765005518 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508765005519 active site 508765005520 substrate binding site [chemical binding]; other site 508765005521 trimer interface [polypeptide binding]; other site 508765005522 CoA binding site [chemical binding]; other site 508765005523 Cupin domain; Region: Cupin_2; cl09118 508765005524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005525 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005527 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 508765005528 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 508765005529 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 508765005530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765005531 FeS/SAM binding site; other site 508765005532 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 508765005533 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 508765005534 SLBB domain; Region: SLBB; pfam10531 508765005535 4Fe-4S binding domain; Region: Fer4; cl02805 508765005536 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508765005537 4Fe-4S binding domain; Region: Fer4; cl02805 508765005538 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765005539 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 508765005540 Hydrogenase formation hypA family; Region: HypD; cl12072 508765005541 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 508765005542 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 508765005543 dimerization interface [polypeptide binding]; other site 508765005544 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 508765005545 ATP binding site [chemical binding]; other site 508765005546 HupF/HypC family; Region: HupF_HypC; cl00394 508765005547 Acylphosphatase; Region: Acylphosphatase; cl00551 508765005548 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 508765005549 HypF finger; Region: zf-HYPF; pfam07503 508765005550 HypF finger; Region: zf-HYPF; pfam07503 508765005551 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 508765005552 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 508765005553 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 508765005554 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 508765005555 nickel binding site [ion binding]; other site 508765005556 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 508765005557 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 508765005558 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 508765005559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508765005560 Helix-turn-helix domains; Region: HTH; cl00088 508765005561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765005562 dimerization interface [polypeptide binding]; other site 508765005563 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 508765005564 4Fe-4S binding domain; Region: Fer4; cl02805 508765005565 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 508765005566 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 508765005567 FMN binding site [chemical binding]; other site 508765005568 dimer interface [polypeptide binding]; other site 508765005569 Putative glucoamylase; Region: Glycoamylase; pfam10091 508765005570 Putative carbohydrate binding domain; Region: CBM_X; cl05621 508765005571 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 508765005572 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 508765005573 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 508765005574 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 508765005575 Putative carbohydrate binding domain; Region: CBM_X; cl05621 508765005576 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 508765005577 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 508765005578 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 508765005579 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765005580 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765005581 ATP-binding cassette protein, ChvD family; Region: ABC_ABC_ChvD; TIGR03719 508765005582 ABC transporter; Region: ABC_tran_2; pfam12848 508765005583 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765005584 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 508765005585 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 508765005586 active site 508765005587 substrate binding site [chemical binding]; other site 508765005588 catalytic site [active] 508765005589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 508765005590 Helix-turn-helix domains; Region: HTH; cl00088 508765005591 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 508765005592 dimerization interface [polypeptide binding]; other site 508765005593 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 508765005594 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 508765005595 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 508765005596 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 508765005597 active site 508765005598 substrate binding site [chemical binding]; other site 508765005599 catalytic site [active] 508765005600 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 508765005601 Dimer interface [polypeptide binding]; other site 508765005602 BRCT sequence motif; other site 508765005603 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508765005604 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508765005605 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 508765005606 homodimer interface [polypeptide binding]; other site 508765005607 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 508765005608 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 508765005609 active site 508765005610 homodimer interface [polypeptide binding]; other site 508765005611 catalytic site [active] 508765005612 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 508765005613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765005614 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765005615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005616 dimer interface [polypeptide binding]; other site 508765005617 conserved gate region; other site 508765005618 putative PBP binding loops; other site 508765005619 ABC-ATPase subunit interface; other site 508765005620 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508765005621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005622 dimer interface [polypeptide binding]; other site 508765005623 conserved gate region; other site 508765005624 putative PBP binding loops; other site 508765005625 ABC-ATPase subunit interface; other site 508765005626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765005627 DNA binding site [nucleotide binding] 508765005628 domain linker motif; other site 508765005629 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508765005630 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 508765005631 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 508765005632 Walker A/P-loop; other site 508765005633 ATP binding site [chemical binding]; other site 508765005634 Q-loop/lid; other site 508765005635 ABC transporter signature motif; other site 508765005636 Walker B; other site 508765005637 D-loop; other site 508765005638 H-loop/switch region; other site 508765005639 Cobalt transport protein; Region: CbiQ; cl00463 508765005640 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 508765005641 PDGLE domain; Region: PDGLE; cl07986 508765005642 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 508765005643 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 508765005644 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 508765005645 Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262 508765005646 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 508765005647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005648 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005650 Family of unknown function (DUF438); Region: DUF438; pfam04282 508765005651 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 508765005652 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 508765005653 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 508765005654 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 508765005655 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765005656 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 508765005657 ligand binding site [chemical binding]; other site 508765005658 flexible hinge region; other site 508765005659 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 508765005660 putative switch regulator; other site 508765005661 non-specific DNA interactions [nucleotide binding]; other site 508765005662 DNA binding site [nucleotide binding] 508765005663 sequence specific DNA binding site [nucleotide binding]; other site 508765005664 putative cAMP binding site [chemical binding]; other site 508765005665 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765005666 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 508765005667 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 508765005668 tetrameric interface [polypeptide binding]; other site 508765005669 activator binding site; other site 508765005670 NADP binding site [chemical binding]; other site 508765005671 substrate binding site [chemical binding]; other site 508765005672 catalytic residues [active] 508765005673 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 508765005674 FAD binding pocket [chemical binding]; other site 508765005675 FAD binding motif [chemical binding]; other site 508765005676 phosphate binding motif [ion binding]; other site 508765005677 beta-alpha-beta structure motif; other site 508765005678 NAD binding pocket [chemical binding]; other site 508765005679 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 508765005680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765005681 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765005682 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508765005683 Rubredoxin; Region: Rubredoxin; pfam00301 508765005684 iron binding site [ion binding]; other site 508765005685 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 508765005686 hybrid cluster protein; Provisional; Region: PRK05290 508765005687 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765005688 ACS interaction site; other site 508765005689 CODH interaction site; other site 508765005690 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 508765005691 hybrid metal cluster; other site 508765005692 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765005693 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 508765005694 Active site serine [active] 508765005695 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 508765005696 Cupin domain; Region: Cupin_2; cl09118 508765005697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005698 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005700 TraX protein; Region: TraX; cl05434 508765005701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765005702 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 508765005703 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765005704 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 508765005705 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 508765005706 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765005707 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765005708 Ca binding site [ion binding]; other site 508765005709 active site 508765005710 catalytic site [active] 508765005711 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 508765005712 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765005713 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765005714 DNA binding site [nucleotide binding] 508765005715 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508765005716 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 508765005717 active site 508765005718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 508765005719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005720 dimer interface [polypeptide binding]; other site 508765005721 conserved gate region; other site 508765005722 putative PBP binding loops; other site 508765005723 ABC-ATPase subunit interface; other site 508765005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765005725 dimer interface [polypeptide binding]; other site 508765005726 conserved gate region; other site 508765005727 putative PBP binding loops; other site 508765005728 ABC-ATPase subunit interface; other site 508765005729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765005730 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 508765005731 active site 508765005732 8-oxo-dGMP binding site [chemical binding]; other site 508765005733 nudix motif; other site 508765005734 metal binding site [ion binding]; metal-binding site 508765005735 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508765005736 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508765005737 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 508765005738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508765005739 putative metal binding site [ion binding]; other site 508765005740 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 508765005741 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765005742 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005743 Mor transcription activator family; Region: Mor; cl02360 508765005744 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 508765005745 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508765005746 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765005747 DNA binding residues [nucleotide binding] 508765005748 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 508765005749 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 508765005750 HsdM N-terminal domain; Region: HsdM_N; pfam12161 508765005751 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 508765005752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765005753 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 508765005754 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 508765005755 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 508765005756 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 508765005757 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 508765005758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765005759 ATP binding site [chemical binding]; other site 508765005760 putative Mg++ binding site [ion binding]; other site 508765005761 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 508765005762 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 508765005763 VanZ like family; Region: VanZ; cl01971 508765005764 Uncharacterized conserved protein [Function unknown]; Region: COG4997 508765005765 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765005766 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 508765005767 methionine cluster; other site 508765005768 active site 508765005769 phosphorylation site [posttranslational modification] 508765005770 metal binding site [ion binding]; metal-binding site 508765005771 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 508765005772 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 508765005773 NAD binding site [chemical binding]; other site 508765005774 sugar binding site [chemical binding]; other site 508765005775 divalent metal binding site [ion binding]; other site 508765005776 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765005777 dimer interface [polypeptide binding]; other site 508765005778 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765005779 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 508765005780 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 508765005781 active site 508765005782 P-loop; other site 508765005783 phosphorylation site [posttranslational modification] 508765005784 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 508765005785 amphipathic channel; other site 508765005786 Asn-Pro-Ala signature motifs; other site 508765005787 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765005788 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 508765005789 dimer interface [polypeptide binding]; other site 508765005790 active site 508765005791 metal binding site [ion binding]; metal-binding site 508765005792 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 508765005793 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 508765005794 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 508765005795 Dehydratase small subunit; Region: Dehydratase_SU; cl02055 508765005796 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 508765005797 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 508765005798 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 508765005799 alpha-beta subunit interface [polypeptide binding]; other site 508765005800 alpha-gamma subunit interface [polypeptide binding]; other site 508765005801 active site 508765005802 substrate and K+ binding site; other site 508765005803 K+ binding site [ion binding]; other site 508765005804 cobalamin binding site [chemical binding]; other site 508765005805 Response regulator receiver domain; Region: Response_reg; pfam00072 508765005806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765005807 active site 508765005808 phosphorylation site [posttranslational modification] 508765005809 intermolecular recognition site; other site 508765005810 dimerization interface [polypeptide binding]; other site 508765005811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005812 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765005813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765005814 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765005815 Sensory domain found in PocR; Region: PocR; pfam10114 508765005816 Histidine kinase; Region: His_kinase; pfam06580 508765005817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765005818 ATP binding site [chemical binding]; other site 508765005819 Mg2+ binding site [ion binding]; other site 508765005820 G-X-G motif; other site 508765005821 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 508765005822 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765005823 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005824 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765005825 Divergent AAA domain; Region: AAA_4; pfam04326 508765005826 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 508765005827 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 508765005828 active site 508765005829 NTP binding site [chemical binding]; other site 508765005830 metal binding triad [ion binding]; metal-binding site 508765005831 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 508765005832 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 508765005833 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 508765005834 active site 508765005835 catalytic tetrad [active] 508765005836 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 508765005837 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 508765005838 Walker A/P-loop; other site 508765005839 ATP binding site [chemical binding]; other site 508765005840 Q-loop/lid; other site 508765005841 ABC transporter signature motif; other site 508765005842 Walker B; other site 508765005843 D-loop; other site 508765005844 H-loop/switch region; other site 508765005845 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765005846 ABC-ATPase subunit interface; other site 508765005847 dimer interface [polypeptide binding]; other site 508765005848 putative PBP binding regions; other site 508765005849 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 508765005850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 508765005851 ABC-ATPase subunit interface; other site 508765005852 dimer interface [polypeptide binding]; other site 508765005853 putative PBP binding regions; other site 508765005854 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 508765005855 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 508765005856 putative ligand binding residues [chemical binding]; other site 508765005857 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 508765005858 FMN binding site [chemical binding]; other site 508765005859 active site 508765005860 catalytic residues [active] 508765005861 substrate binding site [chemical binding]; other site 508765005862 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 508765005863 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 508765005864 transcription elongation factor GreA; Region: greA; TIGR01462 508765005865 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 508765005866 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 508765005867 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 508765005868 active site 508765005869 homodimer interface [polypeptide binding]; other site 508765005870 catalytic site [active] 508765005871 alpha-mannosidase; Provisional; Region: PRK09819 508765005872 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 508765005873 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 508765005874 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 508765005875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765005876 active site 508765005877 phosphorylation site [posttranslational modification] 508765005878 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 508765005879 P-loop; other site 508765005880 active site 508765005881 phosphorylation site [posttranslational modification] 508765005882 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765005883 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 508765005884 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 508765005885 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 508765005886 putative active site [active] 508765005887 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 508765005888 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 508765005889 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765005890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765005891 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765005892 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 508765005893 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765005894 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765005895 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 508765005896 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 508765005897 putative catalytic cysteine [active] 508765005898 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 508765005899 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 508765005900 catalytic triad [active] 508765005901 conserved cis-peptide bond; other site 508765005902 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 508765005903 Predicted acetyltransferase [General function prediction only]; Region: COG3981 508765005904 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005905 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 508765005906 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005907 putative acetyltransferase YhhY; Provisional; Region: PRK10140 508765005908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765005909 Coenzyme A binding pocket [chemical binding]; other site 508765005910 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 508765005911 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765005912 putative active site [active] 508765005913 putative metal binding site [ion binding]; other site 508765005914 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 508765005915 stage II sporulation protein P; Region: spore_II_P; TIGR02867 508765005916 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 508765005917 Helix-turn-helix domains; Region: HTH; cl00088 508765005918 Repair protein; Region: Repair_PSII; cl01535 508765005919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005920 non-specific DNA binding site [nucleotide binding]; other site 508765005921 salt bridge; other site 508765005922 sequence-specific DNA binding site [nucleotide binding]; other site 508765005923 UbiA prenyltransferase family; Region: UbiA; cl00337 508765005924 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 508765005925 catalytic triad [active] 508765005926 conserved cis-peptide bond; other site 508765005927 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765005928 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005929 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765005930 hypothetical protein; Provisional; Region: PRK13795 508765005931 4Fe-4S binding domain; Region: Fer4; cl02805 508765005932 maltose O-acetyltransferase; Provisional; Region: PRK10092 508765005933 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508765005934 active site 508765005935 substrate binding site [chemical binding]; other site 508765005936 trimer interface [polypeptide binding]; other site 508765005937 CoA binding site [chemical binding]; other site 508765005938 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 508765005939 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 508765005940 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 508765005941 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 508765005942 topology modulation protein; Provisional; Region: PRK07261 508765005943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765005944 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765005945 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508765005946 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765005947 putative active site [active] 508765005948 catalytic site [active] 508765005949 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765005950 PLD-like domain; Region: PLDc_2; pfam13091 508765005951 putative active site [active] 508765005952 catalytic site [active] 508765005953 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 508765005954 starch-binding site 2 [chemical binding]; other site 508765005955 starch-binding site 1 [chemical binding]; other site 508765005956 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765005957 putative active site [active] 508765005958 catalytic site [active] 508765005959 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 508765005960 PLD-like domain; Region: PLDc_2; pfam13091 508765005961 putative active site [active] 508765005962 catalytic site [active] 508765005963 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 508765005964 starch-binding site 2 [chemical binding]; other site 508765005965 starch-binding site 1 [chemical binding]; other site 508765005966 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765005967 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 508765005968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765005969 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765005971 Coenzyme A binding pocket [chemical binding]; other site 508765005972 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 508765005973 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508765005974 active site 508765005975 catalytic residues [active] 508765005976 metal binding site [ion binding]; metal-binding site 508765005977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765005978 non-specific DNA binding site [nucleotide binding]; other site 508765005979 salt bridge; other site 508765005980 sequence-specific DNA binding site [nucleotide binding]; other site 508765005981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765005982 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765005983 Coenzyme A binding pocket [chemical binding]; other site 508765005984 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 508765005985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765005986 dimerization interface [polypeptide binding]; other site 508765005987 putative DNA binding site [nucleotide binding]; other site 508765005988 putative Zn2+ binding site [ion binding]; other site 508765005989 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 508765005990 Predicted membrane protein [General function prediction only]; Region: COG4194 508765005991 SdpI/YhfL protein family; Region: SdpI; pfam13630 508765005992 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 508765005993 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 508765005994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765005995 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765005996 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765005997 Cache domain; Region: Cache_1; pfam02743 508765005998 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765005999 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765006000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765006001 dimer interface [polypeptide binding]; other site 508765006002 putative CheW interface [polypeptide binding]; other site 508765006003 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765006004 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508765006005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765006006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765006007 MatE; Region: MatE; cl10513 508765006008 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765006009 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 508765006010 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765006011 TIGR04076 family protein; Region: TIGR04076 508765006012 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 508765006013 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765006014 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 508765006015 Walker A/P-loop; other site 508765006016 ATP binding site [chemical binding]; other site 508765006017 Q-loop/lid; other site 508765006018 ABC transporter signature motif; other site 508765006019 Walker B; other site 508765006020 D-loop; other site 508765006021 H-loop/switch region; other site 508765006022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 508765006023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765006024 ATP binding site [chemical binding]; other site 508765006025 Mg2+ binding site [ion binding]; other site 508765006026 G-X-G motif; other site 508765006027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765006028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765006029 active site 508765006030 phosphorylation site [posttranslational modification] 508765006031 intermolecular recognition site; other site 508765006032 dimerization interface [polypeptide binding]; other site 508765006033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765006034 DNA binding site [nucleotide binding] 508765006035 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765006036 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765006037 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 508765006038 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 508765006039 Walker A/P-loop; other site 508765006040 ATP binding site [chemical binding]; other site 508765006041 Q-loop/lid; other site 508765006042 ABC transporter signature motif; other site 508765006043 Walker B; other site 508765006044 D-loop; other site 508765006045 H-loop/switch region; other site 508765006046 Protein of unknown function DUF45; Region: DUF45; cl00636 508765006047 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765006048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 508765006049 NlpC/P60 family; Region: NLPC_P60; cl11438 508765006050 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 508765006051 Rhomboid family; Region: Rhomboid; cl11446 508765006052 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765006053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765006054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765006055 DNA binding residues [nucleotide binding] 508765006056 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 508765006057 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 508765006058 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765006059 active site 508765006060 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 508765006061 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 508765006062 5S rRNA interface [nucleotide binding]; other site 508765006063 CTC domain interface [polypeptide binding]; other site 508765006064 L16 interface [polypeptide binding]; other site 508765006065 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 508765006066 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 508765006067 5S rRNA interface [nucleotide binding]; other site 508765006068 CTC domain interface [polypeptide binding]; other site 508765006069 L16 interface [polypeptide binding]; other site 508765006070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765006071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765006072 nucleotide binding region [chemical binding]; other site 508765006073 ATP-binding site [chemical binding]; other site 508765006074 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 508765006075 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 508765006076 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 508765006077 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 508765006078 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 508765006079 active site 508765006080 catalytic residue [active] 508765006081 dimer interface [polypeptide binding]; other site 508765006082 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 508765006083 peptidase T; Region: peptidase-T; TIGR01882 508765006084 metal binding site [ion binding]; metal-binding site 508765006085 dimer interface [polypeptide binding]; other site 508765006086 Protein of unknown function (DUF342); Region: DUF342; pfam03961 508765006087 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765006088 Bacterial SH3 domain; Region: SH3_3; cl02551 508765006089 NlpC/P60 family; Region: NLPC_P60; cl11438 508765006090 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 508765006091 PAS domain S-box; Region: sensory_box; TIGR00229 508765006092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765006093 putative active site [active] 508765006094 heme pocket [chemical binding]; other site 508765006095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006096 metal binding site [ion binding]; metal-binding site 508765006097 active site 508765006098 I-site; other site 508765006099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006100 metal binding site [ion binding]; metal-binding site 508765006101 active site 508765006102 I-site; other site 508765006103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765006104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765006105 PAS domain; Region: PAS_9; pfam13426 508765006106 putative active site [active] 508765006107 heme pocket [chemical binding]; other site 508765006108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006109 metal binding site [ion binding]; metal-binding site 508765006110 active site 508765006111 I-site; other site 508765006112 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765006113 metal binding site [ion binding]; metal-binding site 508765006114 active site 508765006115 I-site; other site 508765006116 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 508765006117 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 508765006118 Ligand Binding Site [chemical binding]; other site 508765006119 Sugar fermentation stimulation protein; Region: SfsA; cl00647 508765006120 Helix-turn-helix domains; Region: HTH; cl00088 508765006121 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 508765006122 Helix-turn-helix domains; Region: HTH; cl00088 508765006123 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765006124 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765006125 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765006126 catalytic residue [active] 508765006127 Haemolysin XhlA; Region: XhlA; pfam10779 508765006128 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508765006129 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 508765006130 Phage-related protein [Function unknown]; Region: COG4722; cl15832 508765006131 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 508765006132 Phage-related protein [Function unknown]; Region: COG5412 508765006133 membrane protein P6; Region: PHA01399 508765006134 Phage capsid family; Region: Phage_capsid; pfam05065 508765006135 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 508765006136 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 508765006137 oligomer interface [polypeptide binding]; other site 508765006138 active site residues [active] 508765006139 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 508765006140 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 508765006141 Phage Terminase; Region: Terminase_1; pfam03354 508765006142 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 508765006143 Coat F domain; Region: Coat_F; cl15836 508765006144 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508765006145 Uncharacterized conserved protein [Function unknown]; Region: COG1633 508765006146 dimanganese center [ion binding]; other site 508765006147 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 508765006148 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765006149 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765006150 dimer interface [polypeptide binding]; other site 508765006151 ssDNA binding site [nucleotide binding]; other site 508765006152 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765006153 ParB-like partition proteins; Region: parB_part; TIGR00180 508765006154 ParB-like nuclease domain; Region: ParBc; cl02129 508765006155 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508765006156 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765006157 P-loop; other site 508765006158 Magnesium ion binding site [ion binding]; other site 508765006159 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765006160 Magnesium ion binding site [ion binding]; other site 508765006161 YopX protein; Region: YopX; cl09859 508765006162 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 508765006163 putative replication initiation protein; Region: PHA00330 508765006164 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 508765006165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765006166 non-specific DNA binding site [nucleotide binding]; other site 508765006167 salt bridge; other site 508765006168 sequence-specific DNA binding site [nucleotide binding]; other site 508765006169 YcfA-like protein; Region: YcfA; cl00752 508765006170 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 508765006171 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 508765006172 catalytic residues [active] 508765006173 catalytic nucleophile [active] 508765006174 Recombinase; Region: Recombinase; pfam07508 508765006175 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 508765006176 Sugar fermentation stimulation protein; Region: SfsA; cl00647 508765006177 Low molecular weight phosphatase family; Region: LMWPc; cl00105 508765006178 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 508765006179 active site 508765006180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 508765006181 dimerization interface [polypeptide binding]; other site 508765006182 putative DNA binding site [nucleotide binding]; other site 508765006183 putative Zn2+ binding site [ion binding]; other site 508765006184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765006185 Coenzyme A binding pocket [chemical binding]; other site 508765006186 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765006187 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 508765006188 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765006189 active site 508765006190 phosphorylation site [posttranslational modification] 508765006191 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 508765006192 P-loop; other site 508765006193 active site 508765006194 phosphorylation site [posttranslational modification] 508765006195 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765006196 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 508765006197 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 508765006198 putative substrate binding site [chemical binding]; other site 508765006199 putative ATP binding site [chemical binding]; other site 508765006200 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765006201 Helix-turn-helix domains; Region: HTH; cl00088 508765006202 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765006203 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765006204 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 508765006205 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 508765006206 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765006207 MatE; Region: MatE; cl10513 508765006208 MatE; Region: MatE; cl10513 508765006209 RNA polymerase factor sigma-70; Validated; Region: PRK06811 508765006210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765006211 L-ascorbate oxidase; Region: PLN02191 508765006212 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 508765006213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508765006214 catalytic core [active] 508765006215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 508765006216 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 508765006217 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765006218 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 508765006219 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 508765006220 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 508765006221 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 508765006222 dimer interface [polypeptide binding]; other site 508765006223 [2Fe-2S] cluster binding site [ion binding]; other site 508765006224 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 508765006225 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 508765006226 SLBB domain; Region: SLBB; pfam10531 508765006227 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 508765006228 4Fe-4S binding domain; Region: Fer4; cl02805 508765006229 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 508765006230 4Fe-4S binding domain; Region: Fer4; cl02805 508765006231 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 508765006232 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 508765006233 putative dimer interface [polypeptide binding]; other site 508765006234 [2Fe-2S] cluster binding site [ion binding]; other site 508765006235 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 508765006236 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 508765006237 putative active site [active] 508765006238 catalytic site [active] 508765006239 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 508765006240 putative active site [active] 508765006241 catalytic site [active] 508765006242 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 508765006243 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 508765006244 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 508765006245 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765006246 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765006247 arginine:agmatin antiporter; Provisional; Region: PRK10644 508765006248 Spore germination protein; Region: Spore_permease; cl15802 508765006249 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 508765006250 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 508765006251 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 508765006252 homodimer interface [polypeptide binding]; other site 508765006253 active site 508765006254 FMN binding site [chemical binding]; other site 508765006255 substrate binding site [chemical binding]; other site 508765006256 4Fe-4S binding domain; Region: Fer4; cl02805 508765006257 4Fe-4S binding domain; Region: Fer4; cl02805 508765006258 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 508765006259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765006261 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 508765006262 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 508765006263 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765006264 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 508765006265 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 508765006266 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 508765006267 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 508765006268 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 508765006269 putative metal binding site; other site 508765006270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508765006271 binding surface 508765006272 TPR motif; other site 508765006273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 508765006274 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765006275 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 508765006276 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765006277 inhibitor-cofactor binding pocket; inhibition site 508765006278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765006279 catalytic residue [active] 508765006280 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 508765006281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508765006282 active site 508765006283 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 508765006284 extended (e) SDRs; Region: SDR_e; cd08946 508765006285 NAD(P) binding site [chemical binding]; other site 508765006286 active site 508765006287 substrate binding site [chemical binding]; other site 508765006288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006291 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 508765006292 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765006293 PYR/PP interface [polypeptide binding]; other site 508765006294 dimer interface [polypeptide binding]; other site 508765006295 TPP binding site [chemical binding]; other site 508765006296 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 508765006297 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 508765006298 TPP-binding site [chemical binding]; other site 508765006299 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 508765006300 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765006301 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 508765006302 dimer interface [polypeptide binding]; other site 508765006303 active site 508765006304 NeuB family; Region: NeuB; cl00496 508765006305 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 508765006306 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 508765006307 NAD binding site [chemical binding]; other site 508765006308 homotetramer interface [polypeptide binding]; other site 508765006309 homodimer interface [polypeptide binding]; other site 508765006310 substrate binding site [chemical binding]; other site 508765006311 active site 508765006312 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 508765006313 substrate binding site; other site 508765006314 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 508765006315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006316 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508765006317 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 508765006318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765006319 catalytic residue [active] 508765006320 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 508765006321 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006322 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006323 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 508765006324 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 508765006325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765006326 ATP binding site [chemical binding]; other site 508765006327 putative Mg++ binding site [ion binding]; other site 508765006328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765006329 nucleotide binding region [chemical binding]; other site 508765006330 ATP-binding site [chemical binding]; other site 508765006331 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 508765006332 HSP70 interaction site [polypeptide binding]; other site 508765006333 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765006334 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 508765006335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765006336 ATP binding site [chemical binding]; other site 508765006337 putative Mg++ binding site [ion binding]; other site 508765006338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765006339 nucleotide binding region [chemical binding]; other site 508765006340 ATP-binding site [chemical binding]; other site 508765006341 RQC domain; Region: RQC; cl09632 508765006342 HRDC domain; Region: HRDC; cl02578 508765006343 HRDC domain; Region: HRDC; cl02578 508765006344 Lyc muramidase is an autolytic lysozyme (autolysin) from Clostridium acetobutylicum encoded by the lyc gene. Lyc has a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan...; Region: GH25_Lyc-like; cd06525 508765006345 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 508765006346 active site 508765006347 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 508765006348 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 508765006349 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 508765006350 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 508765006351 dimer interface [polypeptide binding]; other site 508765006352 PYR/PP interface [polypeptide binding]; other site 508765006353 TPP binding site [chemical binding]; other site 508765006354 substrate binding site [chemical binding]; other site 508765006355 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 508765006356 Domain of unknown function; Region: EKR; cl11037 508765006357 4Fe-4S binding domain; Region: Fer4; cl02805 508765006358 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765006359 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 508765006360 TPP-binding site [chemical binding]; other site 508765006361 dimer interface [polypeptide binding]; other site 508765006362 Glycerate kinase family; Region: Gly_kinase; cl00841 508765006363 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 508765006364 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 508765006365 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 508765006366 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 508765006367 Helix-turn-helix domains; Region: HTH; cl00088 508765006368 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 508765006369 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765006370 Glucose inhibited division protein A; Region: GIDA; pfam01134 508765006371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006373 hypothetical protein; Provisional; Region: PRK05802 508765006374 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 508765006375 FAD binding pocket [chemical binding]; other site 508765006376 FAD binding motif [chemical binding]; other site 508765006377 phosphate binding motif [ion binding]; other site 508765006378 beta-alpha-beta structure motif; other site 508765006379 NAD binding pocket [chemical binding]; other site 508765006380 Iron coordination center [ion binding]; other site 508765006381 Protein of unknown function (DUF328); Region: DUF328; cl01143 508765006382 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 508765006383 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765006384 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 508765006385 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 508765006386 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 508765006387 ScpA/B protein; Region: ScpA_ScpB; cl00598 508765006388 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 508765006389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765006390 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 508765006391 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765006392 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 508765006393 DNA binding site [nucleotide binding] 508765006394 Int/Topo IB signature motif; other site 508765006395 active site 508765006396 Integral membrane protein DUF95; Region: DUF95; cl00572 508765006397 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 508765006398 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 508765006399 active site 508765006400 Na/Ca binding site [ion binding]; other site 508765006401 catalytic site [active] 508765006402 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 508765006403 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 508765006404 FAD binding domain; Region: FAD_binding_4; pfam01565 508765006405 Berberine and berberine like; Region: BBE; pfam08031 508765006406 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 508765006407 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 508765006408 large terminase protein; Provisional; Region: 17; PHA02533 508765006409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765006410 non-specific DNA binding site [nucleotide binding]; other site 508765006411 salt bridge; other site 508765006412 sequence-specific DNA binding site [nucleotide binding]; other site 508765006413 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 508765006414 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765006415 Int/Topo IB signature motif; other site 508765006416 active site 508765006417 DNA binding site [nucleotide binding] 508765006418 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 508765006419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765006420 active site 508765006421 phosphorylation site [posttranslational modification] 508765006422 intermolecular recognition site; other site 508765006423 dimerization interface [polypeptide binding]; other site 508765006424 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 508765006425 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 508765006426 protein binding site [polypeptide binding]; other site 508765006427 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 508765006428 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 508765006429 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 508765006430 Walker A/P-loop; other site 508765006431 ATP binding site [chemical binding]; other site 508765006432 Q-loop/lid; other site 508765006433 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 508765006434 Q-loop/lid; other site 508765006435 ABC transporter signature motif; other site 508765006436 Walker B; other site 508765006437 D-loop; other site 508765006438 H-loop/switch region; other site 508765006439 arginine repressor; Provisional; Region: argR; PRK00441 508765006440 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 508765006441 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 508765006442 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 508765006443 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 508765006444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765006445 RNA binding surface [nucleotide binding]; other site 508765006446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765006447 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 508765006448 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 508765006449 TPP-binding site; other site 508765006450 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765006451 PYR/PP interface [polypeptide binding]; other site 508765006452 dimer interface [polypeptide binding]; other site 508765006453 TPP binding site [chemical binding]; other site 508765006454 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765006455 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 508765006456 substrate binding pocket [chemical binding]; other site 508765006457 chain length determination region; other site 508765006458 substrate-Mg2+ binding site; other site 508765006459 catalytic residues [active] 508765006460 aspartate-rich region 1; other site 508765006461 active site lid residues [active] 508765006462 aspartate-rich region 2; other site 508765006463 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 508765006464 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 508765006465 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 508765006466 generic binding surface II; other site 508765006467 generic binding surface I; other site 508765006468 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14172 508765006469 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 508765006470 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 508765006471 homodimer interface [polypeptide binding]; other site 508765006472 NADP binding site [chemical binding]; other site 508765006473 substrate binding site [chemical binding]; other site 508765006474 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 508765006475 putative RNA binding site [nucleotide binding]; other site 508765006476 Asp23 family; Region: Asp23; cl00574 508765006477 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 508765006478 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 508765006479 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 508765006480 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 508765006481 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 508765006482 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 508765006483 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 508765006484 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 508765006485 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 508765006486 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765006487 Walker A motif; other site 508765006488 ATP binding site [chemical binding]; other site 508765006489 elongation factor P; Validated; Region: PRK00529 508765006490 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 508765006491 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 508765006492 RNA binding site [nucleotide binding]; other site 508765006493 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 508765006494 RNA binding site [nucleotide binding]; other site 508765006495 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 508765006496 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 508765006497 Type II/IV secretion system protein; Region: T2SE; pfam00437 508765006498 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765006499 Walker A motif; other site 508765006500 ATP binding site [chemical binding]; other site 508765006501 Walker B motif; other site 508765006502 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 508765006503 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 508765006504 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 508765006505 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 508765006506 Domain of unknown function (DUF814); Region: DUF814; pfam05670 508765006507 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 508765006508 THUMP domain; Region: THUMP; cl12076 508765006509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006510 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765006511 active site 508765006512 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 508765006513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765006514 RNA binding surface [nucleotide binding]; other site 508765006515 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 508765006516 active site 508765006517 DivIVA protein; Region: DivIVA; pfam05103 508765006518 DivIVA domain; Region: DivI1A_domain; TIGR03544 508765006519 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 508765006520 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508765006521 YGGT family; Region: YGGT; cl00508 508765006522 Protein of unknown function (DUF552); Region: DUF552; cl00775 508765006523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 508765006524 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765006525 catalytic residue [active] 508765006526 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 508765006527 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 508765006528 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 508765006529 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 508765006530 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 508765006531 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508765006532 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 508765006533 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 508765006534 Mg++ binding site [ion binding]; other site 508765006535 putative catalytic motif [active] 508765006536 putative substrate binding site [chemical binding]; other site 508765006537 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 508765006538 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508765006539 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765006540 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765006541 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 508765006542 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 508765006543 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765006544 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765006545 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 508765006546 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765006547 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765006548 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 508765006549 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 508765006550 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 508765006551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006552 cell division protein MraZ; Reviewed; Region: PRK00326 508765006553 MraZ protein; Region: MraZ; pfam02381 508765006554 MraZ protein; Region: MraZ; pfam02381 508765006555 Integral membrane protein TerC family; Region: TerC; cl10468 508765006556 GTP-binding protein YchF; Reviewed; Region: PRK09601 508765006557 YchF GTPase; Region: YchF; cd01900 508765006558 G1 box; other site 508765006559 GTP/Mg2+ binding site [chemical binding]; other site 508765006560 Switch I region; other site 508765006561 G2 box; other site 508765006562 Switch II region; other site 508765006563 G3 box; other site 508765006564 G4 box; other site 508765006565 G5 box; other site 508765006566 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 508765006567 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 508765006568 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 508765006569 NodB motif; other site 508765006570 active site 508765006571 catalytic site [active] 508765006572 Cd binding site [ion binding]; other site 508765006573 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 508765006574 O-Antigen ligase; Region: Wzy_C; cl04850 508765006575 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 508765006576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 508765006577 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765006578 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 508765006579 MatE; Region: MatE; cl10513 508765006580 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 508765006581 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765006582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765006583 binding surface 508765006584 TPR motif; other site 508765006585 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 508765006586 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 508765006587 active site 508765006588 substrate binding site [chemical binding]; other site 508765006589 metal binding site [ion binding]; metal-binding site 508765006590 Protein of unknown function (DUF523); Region: DUF523; cl00733 508765006591 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 508765006592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765006593 Walker A/P-loop; other site 508765006594 ATP binding site [chemical binding]; other site 508765006595 Q-loop/lid; other site 508765006596 ABC transporter signature motif; other site 508765006597 Walker B; other site 508765006598 D-loop; other site 508765006599 H-loop/switch region; other site 508765006600 Plant ATP synthase F0; Region: YMF19; cl07975 508765006601 Smr domain; Region: Smr; cl02619 508765006602 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 508765006603 Peptidase family U32; Region: Peptidase_U32; cl03113 508765006604 Collagenase; Region: DUF3656; pfam12392 508765006605 Peptidase family U32; Region: Peptidase_U32; cl03113 508765006606 Cell division protein ZapA; Region: ZapA; cl01146 508765006607 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508765006608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765006609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 508765006610 putative substrate translocation pore; other site 508765006611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765006612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 508765006613 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 508765006614 dimer interface [polypeptide binding]; other site 508765006615 catalytic triad [active] 508765006616 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 508765006617 active site 508765006618 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 508765006619 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 508765006620 chitin/cellulose binding site [chemical binding]; other site 508765006621 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 508765006622 chitin/cellulose binding site [chemical binding]; other site 508765006623 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 508765006624 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 508765006625 putative tRNA-binding site [nucleotide binding]; other site 508765006626 B3/4 domain; Region: B3_4; cl11458 508765006627 tRNA synthetase B5 domain; Region: B5; cl08394 508765006628 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 508765006629 dimer interface [polypeptide binding]; other site 508765006630 motif 1; other site 508765006631 motif 3; other site 508765006632 motif 2; other site 508765006633 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 508765006634 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 508765006635 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 508765006636 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 508765006637 dimer interface [polypeptide binding]; other site 508765006638 motif 1; other site 508765006639 active site 508765006640 motif 2; other site 508765006641 motif 3; other site 508765006642 T-box leader 508765006643 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 508765006644 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 508765006645 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 508765006646 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 508765006647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006648 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 508765006649 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 508765006650 Cation transport protein; Region: TrkH; cl10514 508765006651 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 508765006652 23S rRNA binding site [nucleotide binding]; other site 508765006653 L21 binding site [polypeptide binding]; other site 508765006654 L13 binding site [polypeptide binding]; other site 508765006655 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 508765006656 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 508765006657 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 508765006658 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 508765006659 Ribosomal protein L20 leader 508765006660 YtxC-like family; Region: YtxC; cl08500 508765006661 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 508765006662 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 508765006663 dimerization interface [polypeptide binding]; other site 508765006664 domain crossover interface; other site 508765006665 redox-dependent activation switch; other site 508765006666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765006667 S-adenosylmethionine binding site [chemical binding]; other site 508765006668 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765006669 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 508765006670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006671 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 508765006672 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 508765006673 dihydrodipicolinate synthase; Region: dapA; TIGR00674 508765006674 dimer interface [polypeptide binding]; other site 508765006675 active site 508765006676 catalytic residue [active] 508765006677 dihydrodipicolinate reductase; Provisional; Region: PRK00048 508765006678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765006679 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 508765006680 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 508765006681 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 508765006682 peptide binding site [polypeptide binding]; other site 508765006683 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 508765006684 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 508765006685 Walker A/P-loop; other site 508765006686 ATP binding site [chemical binding]; other site 508765006687 Q-loop/lid; other site 508765006688 ABC transporter signature motif; other site 508765006689 Walker B; other site 508765006690 D-loop; other site 508765006691 H-loop/switch region; other site 508765006692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 508765006693 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 508765006694 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 508765006695 Walker A/P-loop; other site 508765006696 ATP binding site [chemical binding]; other site 508765006697 Q-loop/lid; other site 508765006698 ABC transporter signature motif; other site 508765006699 Walker B; other site 508765006700 D-loop; other site 508765006701 H-loop/switch region; other site 508765006702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 508765006703 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 508765006704 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 508765006705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765006706 dimer interface [polypeptide binding]; other site 508765006707 conserved gate region; other site 508765006708 putative PBP binding loops; other site 508765006709 ABC-ATPase subunit interface; other site 508765006710 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 508765006711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765006712 dimer interface [polypeptide binding]; other site 508765006713 conserved gate region; other site 508765006714 putative PBP binding loops; other site 508765006715 ABC-ATPase subunit interface; other site 508765006716 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 508765006717 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 508765006718 peptide binding site [polypeptide binding]; other site 508765006719 aminotransferase A; Validated; Region: PRK07683 508765006720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765006721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765006722 homodimer interface [polypeptide binding]; other site 508765006723 catalytic residue [active] 508765006724 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 508765006725 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 508765006726 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 508765006727 active site 508765006728 trimer interface [polypeptide binding]; other site 508765006729 substrate binding site [chemical binding]; other site 508765006730 CoA binding site [chemical binding]; other site 508765006731 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 508765006732 putative CoA binding site [chemical binding]; other site 508765006733 putative trimer interface [polypeptide binding]; other site 508765006734 single-stranded DNA-binding protein; Provisional; Region: PRK05813 508765006735 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765006736 dimer interface [polypeptide binding]; other site 508765006737 ssDNA binding site [nucleotide binding]; other site 508765006738 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765006739 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 508765006740 NodB motif; other site 508765006741 active site 508765006742 catalytic site [active] 508765006743 metal binding site [ion binding]; metal-binding site 508765006744 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 508765006745 Uncharacterized conserved protein [Function unknown]; Region: COG3391 508765006746 TSCPD domain; Region: TSCPD; cl14834 508765006747 HIRAN domain; Region: HIRAN; cl07418 508765006748 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 508765006749 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765006750 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 508765006751 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 508765006752 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 508765006753 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508765006754 active site 508765006755 HIGH motif; other site 508765006756 nucleotide binding site [chemical binding]; other site 508765006757 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 508765006758 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 508765006759 active site 508765006760 KMSKS motif; other site 508765006761 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 508765006762 tRNA binding surface [nucleotide binding]; other site 508765006763 anticodon binding site; other site 508765006764 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 508765006765 T-box leader 508765006766 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 508765006767 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 508765006768 Dimer interface [polypeptide binding]; other site 508765006769 anticodon binding site; other site 508765006770 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 508765006771 homodimer interface [polypeptide binding]; other site 508765006772 motif 1; other site 508765006773 motif 2; other site 508765006774 active site 508765006775 motif 3; other site 508765006776 T-box leader 508765006777 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 508765006778 putative dimer interface [polypeptide binding]; other site 508765006779 catalytic triad [active] 508765006780 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 508765006781 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 508765006782 Ligand binding site; other site 508765006783 Putative Catalytic site; other site 508765006784 DXD motif; other site 508765006785 GtrA-like protein; Region: GtrA; cl00971 508765006786 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 508765006787 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 508765006788 dimer interface [polypeptide binding]; other site 508765006789 active site 508765006790 metal binding site [ion binding]; metal-binding site 508765006791 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765006792 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 508765006793 RNA binding surface [nucleotide binding]; other site 508765006794 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 508765006795 probable active site [active] 508765006796 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 508765006797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765006798 dimer interface [polypeptide binding]; other site 508765006799 phosphorylation site [posttranslational modification] 508765006800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765006801 ATP binding site [chemical binding]; other site 508765006802 Mg2+ binding site [ion binding]; other site 508765006803 G-X-G motif; other site 508765006804 UV-endonuclease UvdE; Region: UvdE; cl10036 508765006805 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006806 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 508765006807 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006808 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006809 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006810 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006811 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006812 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006813 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006814 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006815 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006816 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006817 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006818 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006819 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006820 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006821 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006822 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765006823 MATE family multidrug exporter; Provisional; Region: PRK10189 508765006824 MatE; Region: MatE; cl10513 508765006825 MatE; Region: MatE; cl10513 508765006826 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765006827 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 508765006828 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 508765006829 ligand binding site [chemical binding]; other site 508765006830 calcium binding site [ion binding]; other site 508765006831 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765006832 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 508765006833 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765006834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 508765006835 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 508765006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 508765006837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765006838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765006839 binding surface 508765006840 TPR motif; other site 508765006841 TPR repeat; Region: TPR_11; pfam13414 508765006842 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 508765006843 RecX family; Region: RecX; cl00936 508765006844 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508765006845 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508765006846 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508765006847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765006848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765006849 active site 508765006850 phosphorylation site [posttranslational modification] 508765006851 intermolecular recognition site; other site 508765006852 dimerization interface [polypeptide binding]; other site 508765006853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765006854 DNA binding site [nucleotide binding] 508765006855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765006856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765006857 dimerization interface [polypeptide binding]; other site 508765006858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765006859 dimer interface [polypeptide binding]; other site 508765006860 phosphorylation site [posttranslational modification] 508765006861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765006862 ATP binding site [chemical binding]; other site 508765006863 Mg2+ binding site [ion binding]; other site 508765006864 G-X-G motif; other site 508765006865 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 508765006866 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 508765006867 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765006868 catalytic residues [active] 508765006869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765006870 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 508765006871 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 508765006872 Walker A/P-loop; other site 508765006873 ATP binding site [chemical binding]; other site 508765006874 Q-loop/lid; other site 508765006875 ABC transporter signature motif; other site 508765006876 Walker B; other site 508765006877 D-loop; other site 508765006878 H-loop/switch region; other site 508765006879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765006880 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 508765006881 Walker A/P-loop; other site 508765006882 ATP binding site [chemical binding]; other site 508765006883 Q-loop/lid; other site 508765006884 ABC transporter signature motif; other site 508765006885 Walker B; other site 508765006886 D-loop; other site 508765006887 H-loop/switch region; other site 508765006888 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508765006889 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 508765006890 Protein of unknown function (DUF327); Region: DUF327; cl00753 508765006891 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 508765006892 active site 508765006893 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 508765006894 dimer interface [polypeptide binding]; other site 508765006895 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 508765006896 Ligand Binding Site [chemical binding]; other site 508765006897 Molecular Tunnel; other site 508765006898 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 508765006899 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 508765006900 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508765006901 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508765006902 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 508765006903 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 508765006904 trimer interface [polypeptide binding]; other site 508765006905 putative metal binding site [ion binding]; other site 508765006906 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 508765006907 Helix-turn-helix domains; Region: HTH; cl00088 508765006908 Domain of unknown function (DUF378); Region: DUF378; cl00943 508765006909 Predicted membrane protein [Function unknown]; Region: COG4905 508765006910 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 508765006911 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 508765006912 active site 508765006913 metal-binding site [ion binding] 508765006914 nucleotide-binding site [chemical binding]; other site 508765006915 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765006916 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 508765006917 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 508765006918 active site 508765006919 HIGH motif; other site 508765006920 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 508765006921 active site 508765006922 KMSKS motif; other site 508765006923 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 508765006924 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 508765006925 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765006926 FeoA domain; Region: FeoA; cl00838 508765006927 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508765006928 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508765006929 G1 box; other site 508765006930 GTP/Mg2+ binding site [chemical binding]; other site 508765006931 Switch I region; other site 508765006932 G2 box; other site 508765006933 G3 box; other site 508765006934 Switch II region; other site 508765006935 G4 box; other site 508765006936 G5 box; other site 508765006937 Nucleoside recognition; Region: Gate; cl00486 508765006938 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508765006939 Nucleoside recognition; Region: Gate; cl00486 508765006940 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 508765006941 Domain of unknown function DUF20; Region: UPF0118; pfam01594 508765006942 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 508765006943 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 508765006944 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 508765006945 active site 508765006946 HIGH motif; other site 508765006947 KMSK motif region; other site 508765006948 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 508765006949 tRNA binding surface [nucleotide binding]; other site 508765006950 anticodon binding site; other site 508765006951 T-box leader 508765006952 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 508765006953 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 508765006954 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 508765006955 active site 508765006956 putative substrate binding region [chemical binding]; other site 508765006957 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 508765006958 Helix-turn-helix domains; Region: HTH; cl00088 508765006959 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 508765006960 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 508765006961 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 508765006962 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 508765006963 dimer interface [polypeptide binding]; other site 508765006964 active site 508765006965 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 508765006966 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 508765006967 NAD binding site [chemical binding]; other site 508765006968 dimer interface [polypeptide binding]; other site 508765006969 substrate binding site [chemical binding]; other site 508765006970 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765006971 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 508765006972 active site 508765006973 substrate binding site [chemical binding]; other site 508765006974 catalytic site [active] 508765006975 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 508765006976 Rubredoxin; Region: Rubredoxin; pfam00301 508765006977 iron binding site [ion binding]; other site 508765006978 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 508765006979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765006980 FeS/SAM binding site; other site 508765006981 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 508765006982 Pyruvate formate lyase 1; Region: PFL1; cd01678 508765006983 coenzyme A binding site [chemical binding]; other site 508765006984 active site 508765006985 catalytic residues [active] 508765006986 glycine loop; other site 508765006987 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 508765006988 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 508765006989 active site 508765006990 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 508765006991 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 508765006992 heterodimer interface [polypeptide binding]; other site 508765006993 active site 508765006994 FMN binding site [chemical binding]; other site 508765006995 homodimer interface [polypeptide binding]; other site 508765006996 substrate binding site [chemical binding]; other site 508765006997 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 508765006998 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 508765006999 FAD binding pocket [chemical binding]; other site 508765007000 FAD binding motif [chemical binding]; other site 508765007001 phosphate binding motif [ion binding]; other site 508765007002 beta-alpha-beta structure motif; other site 508765007003 NAD binding pocket [chemical binding]; other site 508765007004 Iron coordination center [ion binding]; other site 508765007005 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 508765007006 active site 508765007007 dimer interface [polypeptide binding]; other site 508765007008 dihydroorotase; Validated; Region: pyrC; PRK09357 508765007009 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 508765007010 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 508765007011 active site 508765007012 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 508765007013 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 508765007014 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 508765007015 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 508765007016 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508765007017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765007018 PyrR binding site 508765007019 Bacitracin resistance protein BacA; Region: BacA; cl00858 508765007020 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 508765007021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 508765007022 binding surface 508765007023 TPR motif; other site 508765007024 TPR repeat; Region: TPR_11; pfam13414 508765007025 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 508765007026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 508765007027 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 508765007028 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 508765007029 catalytic triad [active] 508765007030 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 508765007031 NodB motif; other site 508765007032 active site 508765007033 catalytic site [active] 508765007034 Zn binding site [ion binding]; other site 508765007035 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 508765007036 Flavin Reductases; Region: FlaRed; cl00801 508765007037 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 508765007038 ArsC family; Region: ArsC; pfam03960 508765007039 catalytic residue [active] 508765007040 OpgC protein; Region: OpgC_C; cl00792 508765007041 Acyltransferase family; Region: Acyl_transf_3; pfam01757 508765007042 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 508765007043 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 508765007044 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765007045 MatE; Region: MatE; cl10513 508765007046 MatE; Region: MatE; cl10513 508765007047 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765007048 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007049 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765007050 T-box leader 508765007051 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 508765007052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765007053 non-specific DNA binding site [nucleotide binding]; other site 508765007054 salt bridge; other site 508765007055 sequence-specific DNA binding site [nucleotide binding]; other site 508765007056 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 508765007057 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 508765007058 ligand binding site [chemical binding]; other site 508765007059 calcium binding site [ion binding]; other site 508765007060 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 508765007061 putative active site [active] 508765007062 putative metal binding residues [ion binding]; other site 508765007063 signature motif; other site 508765007064 putative dimer interface [polypeptide binding]; other site 508765007065 putative phosphate binding site [ion binding]; other site 508765007066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 508765007067 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 508765007068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765007069 non-specific DNA binding site [nucleotide binding]; other site 508765007070 salt bridge; other site 508765007071 sequence-specific DNA binding site [nucleotide binding]; other site 508765007072 hypothetical protein; Provisional; Region: PRK06771 508765007073 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 508765007074 Methyltransferase domain; Region: Methyltransf_31; pfam13847 508765007075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765007076 S-adenosylmethionine binding site [chemical binding]; other site 508765007077 Phosphotransferase enzyme family; Region: APH; pfam01636 508765007078 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765007079 active site 508765007080 substrate binding site [chemical binding]; other site 508765007081 ATP binding site [chemical binding]; other site 508765007082 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 508765007083 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 508765007084 putative Cl- selectivity filter; other site 508765007085 putative pore gating glutamate residue; other site 508765007086 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 508765007087 MatE; Region: MatE; cl10513 508765007088 MatE; Region: MatE; cl10513 508765007089 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 508765007090 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 508765007091 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 508765007092 active site 508765007093 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 508765007094 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508765007095 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 508765007096 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 508765007097 YvrJ protein family; Region: YvrJ; pfam12841 508765007098 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765007099 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 508765007100 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 508765007101 SEC-C motif; Region: SEC-C; pfam02810 508765007102 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765007103 SEC-C motif; Region: SEC-C; pfam02810 508765007104 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 508765007105 NMT1-like family; Region: NMT1_2; cl15260 508765007106 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 508765007107 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 508765007108 Walker A/P-loop; other site 508765007109 ATP binding site [chemical binding]; other site 508765007110 Q-loop/lid; other site 508765007111 ABC transporter signature motif; other site 508765007112 Walker B; other site 508765007113 D-loop; other site 508765007114 H-loop/switch region; other site 508765007115 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 508765007116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 508765007117 LrgA family; Region: LrgA; cl00608 508765007118 LrgB-like family; Region: LrgB; cl00596 508765007119 DNA topoisomerase III; Provisional; Region: PRK07726 508765007120 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 508765007121 active site 508765007122 putative interdomain interaction site [polypeptide binding]; other site 508765007123 putative metal-binding site [ion binding]; other site 508765007124 putative nucleotide binding site [chemical binding]; other site 508765007125 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 508765007126 domain I; other site 508765007127 DNA binding groove [nucleotide binding] 508765007128 phosphate binding site [ion binding]; other site 508765007129 domain II; other site 508765007130 domain III; other site 508765007131 nucleotide binding site [chemical binding]; other site 508765007132 catalytic site [active] 508765007133 domain IV; other site 508765007134 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 508765007135 TspO/MBR family; Region: TspO_MBR; cl01379 508765007136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 508765007137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007138 dimer interface [polypeptide binding]; other site 508765007139 phosphorylation site [posttranslational modification] 508765007140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007141 ATP binding site [chemical binding]; other site 508765007142 Mg2+ binding site [ion binding]; other site 508765007143 G-X-G motif; other site 508765007144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765007145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007146 dimer interface [polypeptide binding]; other site 508765007147 phosphorylation site [posttranslational modification] 508765007148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007149 ATP binding site [chemical binding]; other site 508765007150 Mg2+ binding site [ion binding]; other site 508765007151 G-X-G motif; other site 508765007152 Predicted membrane protein [Function unknown]; Region: COG1511 508765007153 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508765007154 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765007155 Predicted membrane protein [Function unknown]; Region: COG1511 508765007156 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 508765007157 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765007158 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 508765007159 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 508765007160 N-acetyl-D-glucosamine binding site [chemical binding]; other site 508765007161 catalytic residue [active] 508765007162 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 508765007163 CoA-binding site [chemical binding]; other site 508765007164 DNA polymerase I; Provisional; Region: PRK05755 508765007165 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 508765007166 active site 508765007167 metal binding site 1 [ion binding]; metal-binding site 508765007168 putative 5' ssDNA interaction site; other site 508765007169 metal binding site 3; metal-binding site 508765007170 metal binding site 2 [ion binding]; metal-binding site 508765007171 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 508765007172 putative DNA binding site [nucleotide binding]; other site 508765007173 putative metal binding site [ion binding]; other site 508765007174 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 508765007175 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 508765007176 active site 508765007177 DNA binding site [nucleotide binding] 508765007178 catalytic site [active] 508765007179 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 508765007180 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 508765007181 trimer interface [polypeptide binding]; other site 508765007182 active site 508765007183 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 508765007184 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 508765007185 Helix-turn-helix domains; Region: HTH; cl00088 508765007186 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 508765007187 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 508765007188 putative dimerization interface [polypeptide binding]; other site 508765007189 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765007190 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765007191 dimerization interface [polypeptide binding]; other site 508765007192 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765007193 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007194 dimer interface [polypeptide binding]; other site 508765007195 putative CheW interface [polypeptide binding]; other site 508765007196 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765007197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765007198 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508765007199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765007200 dimer interface [polypeptide binding]; other site 508765007201 conserved gate region; other site 508765007202 putative PBP binding loops; other site 508765007203 ABC-ATPase subunit interface; other site 508765007204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765007205 dimer interface [polypeptide binding]; other site 508765007206 conserved gate region; other site 508765007207 putative PBP binding loops; other site 508765007208 ABC-ATPase subunit interface; other site 508765007209 A new structural DNA glycosylase; Region: AlkD_like; cd06561 508765007210 active site 508765007211 Cache domain; Region: Cache_1; pfam02743 508765007212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765007213 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007214 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765007215 dimer interface [polypeptide binding]; other site 508765007216 putative CheW interface [polypeptide binding]; other site 508765007217 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765007218 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765007219 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007220 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007221 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007222 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765007223 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765007224 active site 508765007225 metal binding site [ion binding]; metal-binding site 508765007226 PilZ domain; Region: PilZ; cl01260 508765007227 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508765007228 Helix-turn-helix domains; Region: HTH; cl00088 508765007229 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 508765007230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765007231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765007232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007233 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765007234 active site 508765007235 motif I; other site 508765007236 motif II; other site 508765007237 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765007238 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 508765007239 putative active site [active] 508765007240 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 508765007241 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 508765007242 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765007243 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765007244 DNA binding residues [nucleotide binding] 508765007245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007246 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 508765007247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765007248 Coenzyme A binding pocket [chemical binding]; other site 508765007249 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 508765007250 nudix motif; other site 508765007251 TfoX N-terminal domain; Region: TfoX_N; cl01167 508765007252 GAD-like domain; Region: GAD-like; pfam08887 508765007253 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 508765007254 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 508765007255 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 508765007256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765007257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007258 dimer interface [polypeptide binding]; other site 508765007259 phosphorylation site [posttranslational modification] 508765007260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007261 ATP binding site [chemical binding]; other site 508765007262 Mg2+ binding site [ion binding]; other site 508765007263 G-X-G motif; other site 508765007264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765007265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765007266 active site 508765007267 phosphorylation site [posttranslational modification] 508765007268 intermolecular recognition site; other site 508765007269 dimerization interface [polypeptide binding]; other site 508765007270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765007271 DNA binding site [nucleotide binding] 508765007272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765007273 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 508765007274 active site 508765007275 FMN binding site [chemical binding]; other site 508765007276 substrate binding site [chemical binding]; other site 508765007277 putative catalytic residue [active] 508765007278 Helix-turn-helix domains; Region: HTH; cl00088 508765007279 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 508765007280 stage V sporulation protein K; Region: spore_V_K; TIGR02881 508765007281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007282 stage V sporulation protein K; Region: spore_V_K; TIGR02881 508765007283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765007284 Walker A motif; other site 508765007285 ATP binding site [chemical binding]; other site 508765007286 Walker B motif; other site 508765007287 arginine finger; other site 508765007288 stage V sporulation protein K; Region: spore_V_K; TIGR02881 508765007289 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 508765007290 active site 508765007291 catalytic residues [active] 508765007292 metal binding site [ion binding]; metal-binding site 508765007293 H+ Antiporter protein; Region: 2A0121; TIGR00900 508765007294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 508765007295 putative substrate translocation pore; other site 508765007296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 508765007297 Helix-turn-helix domains; Region: HTH; cl00088 508765007298 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 508765007299 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 508765007300 Membrane protein of unknown function; Region: DUF360; cl00850 508765007301 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765007302 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765007303 active site 508765007304 catalytic triad [active] 508765007305 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 508765007306 active site 508765007307 catalytic triad [active] 508765007308 Helix-turn-helix domains; Region: HTH; cl00088 508765007309 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765007310 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765007311 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765007312 catalytic residue [active] 508765007313 Haemolysin XhlA; Region: XhlA; pfam10779 508765007314 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 508765007315 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 508765007316 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 508765007317 Fibronectin type III-like domain; Region: Fn3-like; cl15273 508765007318 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 508765007319 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 508765007320 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 508765007321 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 508765007322 Baseplate J-like protein; Region: Baseplate_J; cl01294 508765007323 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 508765007324 Bacterial SH3 domain; Region: SH3_3; cl02551 508765007325 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 508765007326 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 508765007327 Phage XkdN-like protein; Region: XkdN; pfam08890 508765007328 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 508765007329 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 508765007330 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 508765007331 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 508765007332 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 508765007333 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 508765007334 Phage terminase large subunit; Region: Terminase_3; cl12054 508765007335 Terminase-like family; Region: Terminase_6; pfam03237 508765007336 Uncharacterized conserved protein [Function unknown]; Region: COG5484 508765007337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765007338 Terminase small subunit; Region: Terminase_2; cl01513 508765007339 Coat F domain; Region: Coat_F; cl15836 508765007340 Coat F domain; Region: Coat_F; cl15836 508765007341 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508765007342 Uncharacterized conserved protein [Function unknown]; Region: COG1633 508765007343 dimanganese center [ion binding]; other site 508765007344 Membrane protein of unknown function; Region: DUF360; cl00850 508765007345 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 508765007346 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 508765007347 Recombination protein U; Region: RecU; cl01314 508765007348 BRO family, N-terminal domain; Region: Bro-N; cl10591 508765007349 ORF6C domain; Region: ORF6C; pfam10552 508765007350 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 508765007351 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 508765007352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765007353 DNA binding site [nucleotide binding] 508765007354 Int/Topo IB signature motif; other site 508765007355 active site 508765007356 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 508765007357 Active Sites [active] 508765007358 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 508765007359 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765007360 dimer interface [polypeptide binding]; other site 508765007361 ssDNA binding site [nucleotide binding]; other site 508765007362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765007363 HNH endonuclease; Region: HNH_3; pfam13392 508765007364 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 508765007365 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765007366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765007367 RecT family; Region: RecT; cl04285 508765007368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007369 AAA domain; Region: AAA_23; pfam13476 508765007370 Walker A/P-loop; other site 508765007371 ATP binding site [chemical binding]; other site 508765007372 Q-loop/lid; other site 508765007373 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 508765007374 phosphodiesterase; Provisional; Region: PRK12704 508765007375 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765007376 BRO family, N-terminal domain; Region: Bro-N; cl10591 508765007377 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 508765007378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765007379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765007380 Domain of unknown function (DUF955); Region: DUF955; cl01076 508765007381 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 508765007382 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 508765007383 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 508765007384 Int/Topo IB signature motif; other site 508765007385 GGGtGRT protein; Region: GGGtGRT; pfam14057 508765007386 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 508765007387 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 508765007388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 508765007389 hypothetical protein; Provisional; Region: PRK13663 508765007390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 508765007391 active site 508765007392 metal binding site [ion binding]; metal-binding site 508765007393 Protein of unknown function (DUF554); Region: DUF554; cl00784 508765007394 Protein kinase domain; Region: Pkinase; pfam00069 508765007395 Catalytic domain of Protein Kinases; Region: PKc; cd00180 508765007396 active site 508765007397 ATP binding site [chemical binding]; other site 508765007398 substrate binding site [chemical binding]; other site 508765007399 activation loop (A-loop); other site 508765007400 PAS domain S-box; Region: sensory_box; TIGR00229 508765007401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765007402 metal binding site [ion binding]; metal-binding site 508765007403 active site 508765007404 I-site; other site 508765007405 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 508765007406 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 508765007407 catalytic residues [active] 508765007408 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765007409 catalytic residues [active] 508765007410 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 508765007411 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 508765007412 4Fe-4S binding domain; Region: Fer4_5; pfam12801 508765007413 4Fe-4S binding domain; Region: Fer4; cl02805 508765007414 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 508765007415 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 508765007416 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 508765007417 EcsC protein family; Region: EcsC; pfam12787 508765007418 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765007419 EamA-like transporter family; Region: EamA; cl01037 508765007420 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508765007421 Catalytic site [active] 508765007422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765007423 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765007424 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765007425 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765007426 Walker A/P-loop; other site 508765007427 ATP binding site [chemical binding]; other site 508765007428 Q-loop/lid; other site 508765007429 ABC transporter signature motif; other site 508765007430 Walker B; other site 508765007431 D-loop; other site 508765007432 H-loop/switch region; other site 508765007433 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 508765007434 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 508765007435 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765007436 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765007437 Rubredoxin; Region: Rubredoxin; pfam00301 508765007438 iron binding site [ion binding]; other site 508765007439 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508765007440 diiron binding motif [ion binding]; other site 508765007441 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765007442 Rubredoxin; Region: Rubredoxin; pfam00301 508765007443 iron binding site [ion binding]; other site 508765007444 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508765007445 diiron binding motif [ion binding]; other site 508765007446 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 508765007447 active site 508765007448 domain interfaces; other site 508765007449 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 508765007450 Bacteriophage holin; Region: Phage_holin_1; cl02344 508765007451 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 508765007452 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 508765007453 oligomer interface [polypeptide binding]; other site 508765007454 putative active site [active] 508765007455 metal binding site [ion binding]; metal-binding site 508765007456 HPr kinase/phosphorylase; Provisional; Region: PRK05428 508765007457 DRTGG domain; Region: DRTGG; cl12147 508765007458 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 508765007459 Hpr binding site; other site 508765007460 active site 508765007461 homohexamer subunit interaction site [polypeptide binding]; other site 508765007462 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 508765007463 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 508765007464 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 508765007465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007466 Family description; Region: UvrD_C_2; cl15862 508765007467 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 508765007468 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 508765007469 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 508765007470 substrate binding pocket [chemical binding]; other site 508765007471 dimer interface [polypeptide binding]; other site 508765007472 inhibitor binding site; inhibition site 508765007473 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 508765007474 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 508765007475 B12 binding site [chemical binding]; other site 508765007476 cobalt ligand [ion binding]; other site 508765007477 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 508765007478 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 508765007479 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 508765007480 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 508765007481 FAD binding site [chemical binding]; other site 508765007482 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 508765007483 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 508765007484 Mg++ binding site [ion binding]; other site 508765007485 putative catalytic motif [active] 508765007486 substrate binding site [chemical binding]; other site 508765007487 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 508765007488 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 508765007489 putative active site [active] 508765007490 putative metal binding site [ion binding]; other site 508765007491 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 508765007492 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 508765007493 putative peptidoglycan binding site; other site 508765007494 ATP synthase subunit D; Region: ATP-synt_D; cl00613 508765007495 V-type ATP synthase subunit B; Provisional; Region: PRK04196 508765007496 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 508765007497 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 508765007498 Walker A motif homologous position; other site 508765007499 Walker B motif; other site 508765007500 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765007501 V-type ATP synthase subunit A; Provisional; Region: PRK04192 508765007502 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 508765007503 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 508765007504 Walker A motif/ATP binding site; other site 508765007505 Walker B motif; other site 508765007506 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 508765007507 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 508765007508 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 508765007509 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 508765007510 Plant ATP synthase F0; Region: YMF19; cl07975 508765007511 V-type ATP synthase subunit K; Validated; Region: PRK06558 508765007512 ATP synthase subunit C; Region: ATP-synt_C; cl00466 508765007513 ATP synthase subunit C; Region: ATP-synt_C; cl00466 508765007514 V-type ATP synthase subunit I; Validated; Region: PRK05771 508765007515 Plant ATP synthase F0; Region: YMF19; cl07975 508765007516 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 508765007517 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 508765007518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765007519 FeS/SAM binding site; other site 508765007520 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 508765007521 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 508765007522 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508765007523 MatE; Region: MatE; cl10513 508765007524 stage V sporulation protein B; Region: spore_V_B; TIGR02900 508765007525 MatE; Region: MatE; cl10513 508765007526 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 508765007527 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 508765007528 active site 508765007529 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508765007530 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 508765007531 metal binding site [ion binding]; metal-binding site 508765007532 dimer interface [polypeptide binding]; other site 508765007533 cell division protein FtsA; Region: ftsA; TIGR01174 508765007534 Cell division protein FtsA; Region: FtsA; cl11496 508765007535 Cell division protein FtsA; Region: FtsA; cl11496 508765007536 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 508765007537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007538 Family description; Region: UvrD_C_2; cl15862 508765007539 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 508765007540 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 508765007541 active site 508765007542 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 508765007543 metal binding site 2 [ion binding]; metal-binding site 508765007544 putative DNA binding helix; other site 508765007545 metal binding site 1 [ion binding]; metal-binding site 508765007546 dimer interface [polypeptide binding]; other site 508765007547 structural Zn2+ binding site [ion binding]; other site 508765007548 Predicted GTPase [General function prediction only]; Region: COG0218 508765007549 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 508765007550 G1 box; other site 508765007551 GTP/Mg2+ binding site [chemical binding]; other site 508765007552 Switch I region; other site 508765007553 G2 box; other site 508765007554 G3 box; other site 508765007555 Switch II region; other site 508765007556 G4 box; other site 508765007557 G5 box; other site 508765007558 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 508765007559 Found in ATP-dependent protease La (LON); Region: LON; smart00464 508765007560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765007561 Walker A motif; other site 508765007562 ATP binding site [chemical binding]; other site 508765007563 Walker B motif; other site 508765007564 arginine finger; other site 508765007565 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 508765007566 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 508765007567 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 508765007568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765007569 Walker A motif; other site 508765007570 ATP binding site [chemical binding]; other site 508765007571 Walker B motif; other site 508765007572 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 508765007573 Clp protease; Region: CLP_protease; pfam00574 508765007574 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 508765007575 oligomer interface [polypeptide binding]; other site 508765007576 active site residues [active] 508765007577 trigger factor; Provisional; Region: tig; PRK01490 508765007578 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 508765007579 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 508765007580 histidinol-phosphatase; Provisional; Region: PRK05588 508765007581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 508765007582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 508765007583 Coenzyme A binding pocket [chemical binding]; other site 508765007584 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765007585 hypothetical protein; Provisional; Region: PRK04435 508765007586 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 508765007587 homoserine kinase; Provisional; Region: PRK01212 508765007588 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 508765007589 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 508765007590 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 508765007591 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 508765007592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007593 catalytic residue [active] 508765007594 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 508765007595 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 508765007596 Ion channel; Region: Ion_trans_2; cl11596 508765007597 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 508765007598 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 508765007599 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 508765007600 active site 508765007601 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 508765007602 active site 508765007603 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 508765007604 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 508765007605 inhibitor-cofactor binding pocket; inhibition site 508765007606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007607 catalytic residue [active] 508765007608 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 508765007609 dimer interface [polypeptide binding]; other site 508765007610 active site 508765007611 Schiff base residues; other site 508765007612 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765007613 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 508765007614 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 508765007615 active site 508765007616 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 508765007617 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 508765007618 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 508765007619 domain interfaces; other site 508765007620 active site 508765007621 precorrin-2 dehydrogenase; Provisional; Region: PRK05562 508765007622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765007623 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 508765007624 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 508765007625 tRNA; other site 508765007626 putative tRNA binding site [nucleotide binding]; other site 508765007627 putative NADP binding site [chemical binding]; other site 508765007628 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 508765007629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765007630 4Fe-4S binding domain; Region: Fer4; cl02805 508765007631 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 508765007632 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 508765007633 catalytic residue [active] 508765007634 putative FPP diphosphate binding site; other site 508765007635 putative FPP binding hydrophobic cleft; other site 508765007636 dimer interface [polypeptide binding]; other site 508765007637 putative IPP diphosphate binding site; other site 508765007638 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 508765007639 homoserine O-succinyltransferase; Provisional; Region: PRK05368 508765007640 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 508765007641 proposed active site lysine [active] 508765007642 conserved cys residue [active] 508765007643 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 508765007644 sugar phosphate phosphatase; Provisional; Region: PRK10513 508765007645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007646 active site 508765007647 motif I; other site 508765007648 motif II; other site 508765007649 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765007650 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 508765007651 Domain of unknown function DUF; Region: DUF204; pfam02659 508765007652 cobyric acid synthase; Provisional; Region: PRK00784 508765007653 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007655 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 508765007656 catalytic triad [active] 508765007657 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 508765007658 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765007659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765007660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007661 homodimer interface [polypeptide binding]; other site 508765007662 catalytic residue [active] 508765007663 CobD/Cbib protein; Region: CobD_Cbib; cl00561 508765007664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508765007665 catalytic core [active] 508765007666 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007667 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 508765007668 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007669 ATP binding site [chemical binding]; other site 508765007670 Walker B motif; other site 508765007671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007672 Walker A motif; other site 508765007673 ATP binding site [chemical binding]; other site 508765007674 Walker B motif; other site 508765007675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765007676 dimer interface [polypeptide binding]; other site 508765007677 conserved gate region; other site 508765007678 putative PBP binding loops; other site 508765007679 ABC-ATPase subunit interface; other site 508765007680 NMT1-like family; Region: NMT1_2; cl15260 508765007681 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 508765007682 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 508765007683 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 508765007684 Walker A/P-loop; other site 508765007685 ATP binding site [chemical binding]; other site 508765007686 Q-loop/lid; other site 508765007687 ABC transporter signature motif; other site 508765007688 Walker B; other site 508765007689 D-loop; other site 508765007690 H-loop/switch region; other site 508765007691 FOG: CBS domain [General function prediction only]; Region: COG0517 508765007692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 508765007693 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765007694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765007695 DNA-binding site [nucleotide binding]; DNA binding site 508765007696 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 508765007697 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 508765007698 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 508765007699 putative dimer interface [polypeptide binding]; other site 508765007700 active site pocket [active] 508765007701 putative cataytic base [active] 508765007702 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 508765007703 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 508765007704 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765007705 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 508765007706 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 508765007707 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 508765007708 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 508765007709 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 508765007710 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765007711 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 508765007712 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765007713 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 508765007714 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 508765007715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765007716 S-adenosylmethionine binding site [chemical binding]; other site 508765007717 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765007718 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 508765007719 CbiD; Region: CbiD; cl00828 508765007720 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 508765007721 Precorrin-8X methylmutase; Region: CbiC; pfam02570 508765007722 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 508765007723 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 508765007724 catalytic triad [active] 508765007725 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 508765007726 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 508765007727 active site 508765007728 C-terminal domain interface [polypeptide binding]; other site 508765007729 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 508765007730 active site 508765007731 N-terminal domain interface [polypeptide binding]; other site 508765007732 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 508765007733 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 508765007734 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 508765007735 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 508765007736 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 508765007737 putative active site [active] 508765007738 metal binding site [ion binding]; metal-binding site 508765007739 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 508765007740 uracil-xanthine permease; Region: ncs2; TIGR00801 508765007741 PyrR binding site 508765007742 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765007743 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765007744 catalytic residue [active] 508765007745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765007746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007747 dimer interface [polypeptide binding]; other site 508765007748 putative CheW interface [polypeptide binding]; other site 508765007749 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765007750 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 508765007751 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 508765007752 Walker A/P-loop; other site 508765007753 ATP binding site [chemical binding]; other site 508765007754 Q-loop/lid; other site 508765007755 ABC transporter signature motif; other site 508765007756 Walker B; other site 508765007757 D-loop; other site 508765007758 H-loop/switch region; other site 508765007759 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 508765007760 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 508765007761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007762 Walker A/P-loop; other site 508765007763 ATP binding site [chemical binding]; other site 508765007764 Q-loop/lid; other site 508765007765 ABC transporter signature motif; other site 508765007766 Walker B; other site 508765007767 D-loop; other site 508765007768 H-loop/switch region; other site 508765007769 Helix-turn-helix domains; Region: HTH; cl00088 508765007770 ribulokinase; Provisional; Region: PRK04123 508765007771 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 508765007772 putative N- and C-terminal domain interface [polypeptide binding]; other site 508765007773 putative active site [active] 508765007774 putative MgATP binding site [chemical binding]; other site 508765007775 catalytic site [active] 508765007776 metal binding site [ion binding]; metal-binding site 508765007777 carbohydrate binding site [chemical binding]; other site 508765007778 homodimer interface [polypeptide binding]; other site 508765007779 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 508765007780 active site 508765007781 metal binding site [ion binding]; metal-binding site 508765007782 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 508765007783 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765007784 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765007785 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765007786 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765007787 DNA binding site [nucleotide binding] 508765007788 domain linker motif; other site 508765007789 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765007790 dimerization interface [polypeptide binding]; other site 508765007791 ligand binding site [chemical binding]; other site 508765007792 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 508765007793 ZIP Zinc transporter; Region: Zip; pfam02535 508765007794 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 508765007795 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 508765007796 nucleotide binding site/active site [active] 508765007797 HIT family signature motif; other site 508765007798 catalytic residue [active] 508765007799 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 508765007800 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 508765007801 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765007802 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 508765007803 ArsC family; Region: ArsC; pfam03960 508765007804 putative ArsC-like catalytic residues; other site 508765007805 putative TRX-like catalytic residues [active] 508765007806 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765007807 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765007808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765007809 Zn2+ binding site [ion binding]; other site 508765007810 Mg2+ binding site [ion binding]; other site 508765007811 Domain of unknown function (DUF368); Region: DUF368; cl00893 508765007812 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765007813 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508765007814 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 508765007815 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 508765007816 active site 508765007817 catalytic motif [active] 508765007818 Zn binding site [ion binding]; other site 508765007819 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508765007820 TM-ABC transporter signature motif; other site 508765007821 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 508765007822 TM-ABC transporter signature motif; other site 508765007823 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 508765007824 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 508765007825 Walker A/P-loop; other site 508765007826 ATP binding site [chemical binding]; other site 508765007827 Q-loop/lid; other site 508765007828 ABC transporter signature motif; other site 508765007829 Walker B; other site 508765007830 D-loop; other site 508765007831 H-loop/switch region; other site 508765007832 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 508765007833 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 508765007834 ligand binding site [chemical binding]; other site 508765007835 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765007836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765007837 DNA binding site [nucleotide binding] 508765007838 domain linker motif; other site 508765007839 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 508765007840 dimerization interface [polypeptide binding]; other site 508765007841 ligand binding site [chemical binding]; other site 508765007842 hypothetical protein; Validated; Region: PRK07682 508765007843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765007844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765007845 homodimer interface [polypeptide binding]; other site 508765007846 catalytic residue [active] 508765007847 Helix-turn-helix domains; Region: HTH; cl00088 508765007848 T-box leader 508765007849 pullulanase, type I; Region: pulA_typeI; TIGR02104 508765007850 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 508765007851 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 508765007852 Ca binding site [ion binding]; other site 508765007853 active site 508765007854 catalytic site [active] 508765007855 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 508765007856 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 508765007857 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765007858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765007859 catalytic residue [active] 508765007860 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 508765007861 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 508765007862 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 508765007863 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 508765007864 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 508765007865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007866 Walker A/P-loop; other site 508765007867 ATP binding site [chemical binding]; other site 508765007868 Q-loop/lid; other site 508765007869 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765007870 ABC transporter; Region: ABC_tran_2; pfam12848 508765007871 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 508765007872 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007873 dimer interface [polypeptide binding]; other site 508765007874 putative CheW interface [polypeptide binding]; other site 508765007875 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 508765007876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 508765007877 FeS/SAM binding site; other site 508765007878 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 508765007879 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 508765007880 heat shock protein 90; Provisional; Region: PRK05218 508765007881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 508765007882 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 508765007883 maltose O-acetyltransferase; Provisional; Region: PRK10092 508765007884 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 508765007885 active site 508765007886 substrate binding site [chemical binding]; other site 508765007887 trimer interface [polypeptide binding]; other site 508765007888 CoA binding site [chemical binding]; other site 508765007889 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 508765007890 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 508765007891 Walker A/P-loop; other site 508765007892 ATP binding site [chemical binding]; other site 508765007893 Q-loop/lid; other site 508765007894 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765007895 ABC transporter signature motif; other site 508765007896 Walker B; other site 508765007897 D-loop; other site 508765007898 H-loop/switch region; other site 508765007899 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 508765007900 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 508765007901 active site 508765007902 metal binding site [ion binding]; metal-binding site 508765007903 DNA binding site [nucleotide binding] 508765007904 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 508765007905 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765007906 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 508765007907 putative active site [active] 508765007908 Survival protein SurE; Region: SurE; cl00448 508765007909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765007910 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 508765007911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765007912 dimerization interface [polypeptide binding]; other site 508765007913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765007914 dimer interface [polypeptide binding]; other site 508765007915 putative CheW interface [polypeptide binding]; other site 508765007916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007917 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765007918 active site 508765007919 motif I; other site 508765007920 motif II; other site 508765007921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007922 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765007923 Helix-turn-helix domains; Region: HTH; cl00088 508765007924 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765007925 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 508765007926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765007927 putative kinase; Provisional; Region: PRK09954 508765007928 Helix-turn-helix domains; Region: HTH; cl00088 508765007929 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 508765007930 substrate binding site [chemical binding]; other site 508765007931 ATP binding site [chemical binding]; other site 508765007932 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765007933 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 508765007934 active site 508765007935 NAD binding site [chemical binding]; other site 508765007936 metal binding site [ion binding]; metal-binding site 508765007937 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 508765007938 active site 508765007939 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 508765007940 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765007941 substrate binding site [chemical binding]; other site 508765007942 ATP binding site [chemical binding]; other site 508765007943 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 508765007944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765007945 DNA binding residues [nucleotide binding] 508765007946 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 508765007947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765007948 active site 508765007949 motif I; other site 508765007950 motif II; other site 508765007951 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765007952 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 508765007953 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 508765007954 Zn binding site [ion binding]; other site 508765007955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765007956 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 508765007957 Walker A/P-loop; other site 508765007958 ATP binding site [chemical binding]; other site 508765007959 Q-loop/lid; other site 508765007960 ABC transporter signature motif; other site 508765007961 Walker B; other site 508765007962 D-loop; other site 508765007963 H-loop/switch region; other site 508765007964 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765007965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765007966 dimerization interface [polypeptide binding]; other site 508765007967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765007968 dimer interface [polypeptide binding]; other site 508765007969 phosphorylation site [posttranslational modification] 508765007970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765007971 ATP binding site [chemical binding]; other site 508765007972 Mg2+ binding site [ion binding]; other site 508765007973 G-X-G motif; other site 508765007974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765007975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765007976 active site 508765007977 phosphorylation site [posttranslational modification] 508765007978 intermolecular recognition site; other site 508765007979 dimerization interface [polypeptide binding]; other site 508765007980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765007981 DNA binding site [nucleotide binding] 508765007982 Endonuclease I; Region: Endonuclease_1; cl01003 508765007983 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 508765007984 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765007985 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 508765007986 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 508765007987 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 508765007988 active site 508765007989 PreQ1 riboswitch 508765007990 EamA-like transporter family; Region: EamA; cl01037 508765007991 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765007992 Rubredoxin; Region: Rubredoxin; pfam00301 508765007993 iron binding site [ion binding]; other site 508765007994 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 508765007995 diiron binding motif [ion binding]; other site 508765007996 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765007997 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765007998 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 508765007999 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 508765008000 G1 box; other site 508765008001 GTP/Mg2+ binding site [chemical binding]; other site 508765008002 Switch I region; other site 508765008003 G2 box; other site 508765008004 G3 box; other site 508765008005 Switch II region; other site 508765008006 G4 box; other site 508765008007 G5 box; other site 508765008008 Nucleoside recognition; Region: Gate; cl00486 508765008009 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 508765008010 Nucleoside recognition; Region: Gate; cl00486 508765008011 FeoA domain; Region: FeoA; cl00838 508765008012 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 508765008013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765008015 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765008016 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 508765008017 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765008018 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 508765008019 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 508765008020 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 508765008021 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 508765008022 active site 508765008023 Zn binding site [ion binding]; other site 508765008024 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 508765008025 CotJB protein; Region: CotJB; pfam12652 508765008026 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 508765008027 dimanganese center [ion binding]; other site 508765008028 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 508765008029 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 508765008030 4Fe-4S binding domain; Region: Fer4; cl02805 508765008031 4Fe-4S binding domain; Region: Fer4; cl02805 508765008032 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 508765008033 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 508765008034 FAD binding pocket [chemical binding]; other site 508765008035 FAD binding motif [chemical binding]; other site 508765008036 phosphate binding motif [ion binding]; other site 508765008037 beta-alpha-beta structure motif; other site 508765008038 NAD binding pocket [chemical binding]; other site 508765008039 Iron coordination center [ion binding]; other site 508765008040 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 508765008041 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 508765008042 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 508765008043 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 508765008044 ligand binding site [chemical binding]; other site 508765008045 flexible hinge region; other site 508765008046 Helix-turn-helix domains; Region: HTH; cl00088 508765008047 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 508765008048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765008049 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 508765008050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765008051 putative oxidoreductase; Provisional; Region: PRK12831 508765008052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008053 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508765008054 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508765008055 FAD binding pocket [chemical binding]; other site 508765008056 FAD binding motif [chemical binding]; other site 508765008057 phosphate binding motif [ion binding]; other site 508765008058 beta-alpha-beta structure motif; other site 508765008059 NAD binding pocket [chemical binding]; other site 508765008060 Iron coordination center [ion binding]; other site 508765008061 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 508765008062 SmpB-tmRNA interface; other site 508765008063 ribonuclease R; Region: RNase_R; TIGR02063 508765008064 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508765008065 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 508765008066 RNB domain; Region: RNB; pfam00773 508765008067 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 508765008068 RNA binding site [nucleotide binding]; other site 508765008069 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 508765008070 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 508765008071 Preprotein translocase SecG subunit; Region: SecG; cl09123 508765008072 enolase; Provisional; Region: eno; PRK00077 508765008073 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 508765008074 dimer interface [polypeptide binding]; other site 508765008075 metal binding site [ion binding]; metal-binding site 508765008076 substrate binding pocket [chemical binding]; other site 508765008077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765008078 active site 508765008079 ATP binding site [chemical binding]; other site 508765008080 substrate binding site [chemical binding]; other site 508765008081 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 508765008082 Sulfatase; Region: Sulfatase; cl10460 508765008083 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 508765008084 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 508765008085 putative active site [active] 508765008086 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 508765008087 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765008088 active site turn [active] 508765008089 phosphorylation site [posttranslational modification] 508765008090 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765008091 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 508765008092 Sensory domain found in PocR; Region: PocR; pfam10114 508765008093 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 508765008094 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008095 dimer interface [polypeptide binding]; other site 508765008096 putative CheW interface [polypeptide binding]; other site 508765008097 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 508765008098 substrate binding site [chemical binding]; other site 508765008099 dimer interface [polypeptide binding]; other site 508765008100 catalytic triad [active] 508765008101 Phosphoglycerate kinase; Region: PGK; pfam00162 508765008102 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 508765008103 substrate binding site [chemical binding]; other site 508765008104 hinge regions; other site 508765008105 ADP binding site [chemical binding]; other site 508765008106 catalytic site [active] 508765008107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008108 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 508765008109 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 508765008110 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 508765008111 Predicted transcriptional regulator [Transcription]; Region: COG3388 508765008112 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 508765008113 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 508765008114 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 508765008115 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 508765008116 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 508765008117 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 508765008118 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 508765008119 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 508765008120 VanW like protein; Region: VanW; pfam04294 508765008121 G5 domain; Region: G5; pfam07501 508765008122 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 508765008123 active site 508765008124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008125 dimerization interface [polypeptide binding]; other site 508765008126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765008127 dimer interface [polypeptide binding]; other site 508765008128 phosphorylation site [posttranslational modification] 508765008129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008130 ATP binding site [chemical binding]; other site 508765008131 Mg2+ binding site [ion binding]; other site 508765008132 G-X-G motif; other site 508765008133 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008135 active site 508765008136 phosphorylation site [posttranslational modification] 508765008137 intermolecular recognition site; other site 508765008138 dimerization interface [polypeptide binding]; other site 508765008139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008140 DNA binding site [nucleotide binding] 508765008141 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 508765008142 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 508765008143 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765008144 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 508765008145 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 508765008146 minor groove reading motif; other site 508765008147 helix-hairpin-helix signature motif; other site 508765008148 substrate binding pocket [chemical binding]; other site 508765008149 active site 508765008150 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 508765008151 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 508765008152 putative acyl-acceptor binding pocket; other site 508765008153 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 508765008154 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 508765008155 serine O-acetyltransferase; Region: cysE; TIGR01172 508765008156 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 508765008157 trimer interface [polypeptide binding]; other site 508765008158 active site 508765008159 substrate binding site [chemical binding]; other site 508765008160 CoA binding site [chemical binding]; other site 508765008161 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508765008162 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508765008163 dimer interface [polypeptide binding]; other site 508765008164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008165 catalytic residue [active] 508765008166 T-box leader 508765008167 MgtE intracellular N domain; Region: MgtE_N; cl15244 508765008168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 508765008169 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 508765008170 hypothetical protein; Provisional; Region: PRK00955 508765008171 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 508765008172 putative lipid kinase; Reviewed; Region: PRK13059 508765008173 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 508765008174 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 508765008175 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765008176 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508765008177 binuclear metal center [ion binding]; other site 508765008178 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 508765008179 iron binding site [ion binding]; other site 508765008180 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 508765008181 SpoVR like protein; Region: SpoVR; pfam04293 508765008182 Uncharacterized conserved protein [Function unknown]; Region: COG2718 508765008183 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 508765008184 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 508765008185 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 508765008186 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 508765008187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765008188 ATP binding site [chemical binding]; other site 508765008189 putative Mg++ binding site [ion binding]; other site 508765008190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765008191 nucleotide binding region [chemical binding]; other site 508765008192 ATP-binding site [chemical binding]; other site 508765008193 RQC domain; Region: RQC; cl09632 508765008194 HRDC domain; Region: HRDC; cl02578 508765008195 FtsX-like permease family; Region: FtsX; cl15850 508765008196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765008197 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765008198 Walker A/P-loop; other site 508765008199 ATP binding site [chemical binding]; other site 508765008200 Q-loop/lid; other site 508765008201 ABC transporter signature motif; other site 508765008202 Walker B; other site 508765008203 D-loop; other site 508765008204 H-loop/switch region; other site 508765008205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765008206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765008207 ATP binding site [chemical binding]; other site 508765008208 Mg2+ binding site [ion binding]; other site 508765008209 G-X-G motif; other site 508765008210 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008212 active site 508765008213 phosphorylation site [posttranslational modification] 508765008214 intermolecular recognition site; other site 508765008215 dimerization interface [polypeptide binding]; other site 508765008216 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008217 DNA binding site [nucleotide binding] 508765008218 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 508765008219 Rubrerythrin [Energy production and conversion]; Region: COG1592 508765008220 binuclear metal center [ion binding]; other site 508765008221 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 508765008222 iron binding site [ion binding]; other site 508765008223 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 508765008224 nucleophile elbow; other site 508765008225 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 508765008226 thiamine phosphate binding site [chemical binding]; other site 508765008227 active site 508765008228 pyrophosphate binding site [ion binding]; other site 508765008229 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 508765008230 substrate binding site [chemical binding]; other site 508765008231 multimerization interface [polypeptide binding]; other site 508765008232 ATP binding site [chemical binding]; other site 508765008233 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 508765008234 dimer interface [polypeptide binding]; other site 508765008235 substrate binding site [chemical binding]; other site 508765008236 ATP binding site [chemical binding]; other site 508765008237 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 508765008238 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 508765008239 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 508765008240 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 508765008241 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 508765008242 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 508765008243 putative L-serine binding site [chemical binding]; other site 508765008244 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 508765008245 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 508765008246 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 508765008247 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 508765008248 active site 508765008249 Protein of unknown function (DUF421); Region: DUF421; cl00990 508765008250 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 508765008251 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508765008252 hypothetical protein; Provisional; Region: PRK08185 508765008253 intersubunit interface [polypeptide binding]; other site 508765008254 active site 508765008255 zinc binding site [ion binding]; other site 508765008256 Na+ binding site [ion binding]; other site 508765008257 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 508765008258 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 508765008259 ANP binding site [chemical binding]; other site 508765008260 Substrate Binding Site II [chemical binding]; other site 508765008261 Substrate Binding Site I [chemical binding]; other site 508765008262 argininosuccinate lyase; Provisional; Region: PRK00855 508765008263 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 508765008264 active sites [active] 508765008265 tetramer interface [polypeptide binding]; other site 508765008266 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 508765008267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008268 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 508765008269 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 508765008270 heterotetramer interface [polypeptide binding]; other site 508765008271 active site pocket [active] 508765008272 cleavage site 508765008273 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 508765008274 feedback inhibition sensing region; other site 508765008275 homohexameric interface [polypeptide binding]; other site 508765008276 nucleotide binding site [chemical binding]; other site 508765008277 N-acetyl-L-glutamate binding site [chemical binding]; other site 508765008278 acetylornithine aminotransferase; Provisional; Region: PRK02627 508765008279 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 508765008280 inhibitor-cofactor binding pocket; inhibition site 508765008281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008282 catalytic residue [active] 508765008283 ornithine carbamoyltransferase; Provisional; Region: PRK00779 508765008284 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 508765008285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765008287 metal binding site [ion binding]; metal-binding site 508765008288 active site 508765008289 I-site; other site 508765008290 Nucleoid-associated protein [General function prediction only]; Region: COG3081 508765008291 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 508765008292 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 508765008293 putative active site [active] 508765008294 putative metal binding residues [ion binding]; other site 508765008295 signature motif; other site 508765008296 putative triphosphate binding site [ion binding]; other site 508765008297 dimer interface [polypeptide binding]; other site 508765008298 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 508765008299 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 508765008300 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 508765008301 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 508765008302 putative substrate binding site [chemical binding]; other site 508765008303 putative ATP binding site [chemical binding]; other site 508765008304 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 508765008305 hypothetical protein; Provisional; Region: PRK08185 508765008306 intersubunit interface [polypeptide binding]; other site 508765008307 active site 508765008308 zinc binding site [ion binding]; other site 508765008309 Na+ binding site [ion binding]; other site 508765008310 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765008311 active pocket/dimerization site; other site 508765008312 active site 508765008313 phosphorylation site [posttranslational modification] 508765008314 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 508765008315 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 508765008316 dimer interface [polypeptide binding]; other site 508765008317 active site 508765008318 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 508765008319 putative active site [active] 508765008320 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 508765008321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765008322 DNA-binding site [nucleotide binding]; DNA binding site 508765008323 UTRA domain; Region: UTRA; cl01230 508765008324 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 508765008325 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 508765008326 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 508765008327 active site 508765008328 phosphorylation site [posttranslational modification] 508765008329 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 508765008330 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 508765008331 active site 508765008332 dimer interface [polypeptide binding]; other site 508765008333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008334 Prephenate dehydrogenase; Region: PDH; pfam02153 508765008335 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 508765008336 NeuB family; Region: NeuB; cl00496 508765008337 shikimate kinase; Reviewed; Region: aroK; PRK00131 508765008338 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 508765008339 ADP binding site [chemical binding]; other site 508765008340 magnesium binding site [ion binding]; other site 508765008341 putative shikimate binding site; other site 508765008342 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 508765008343 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 508765008344 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 508765008345 shikimate binding site; other site 508765008346 NAD(P) binding site [chemical binding]; other site 508765008347 Chorismate mutase type II; Region: CM_2; cl00693 508765008348 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 508765008349 Prephenate dehydratase; Region: PDT; pfam00800 508765008350 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 508765008351 putative L-Phe binding site [chemical binding]; other site 508765008352 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 508765008353 Tetramer interface [polypeptide binding]; other site 508765008354 active site 508765008355 FMN-binding site [chemical binding]; other site 508765008356 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 508765008357 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 508765008358 hinge; other site 508765008359 active site 508765008360 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 508765008361 active site 508765008362 dimer interface [polypeptide binding]; other site 508765008363 metal binding site [ion binding]; metal-binding site 508765008364 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 508765008365 NeuB family; Region: NeuB; cl00496 508765008366 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 508765008367 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 508765008368 active site 508765008369 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 508765008370 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 508765008371 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 508765008372 putative active site [active] 508765008373 catalytic site [active] 508765008374 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 508765008375 putative active site [active] 508765008376 catalytic site [active] 508765008377 Sodium:solute symporter family; Region: SSF; cl00456 508765008378 T-box leader 508765008379 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 508765008380 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 508765008381 HIGH motif; other site 508765008382 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 508765008383 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 508765008384 active site 508765008385 KMSKS motif; other site 508765008386 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 508765008387 tRNA binding surface [nucleotide binding]; other site 508765008388 Cache domain; Region: Cache_1; pfam02743 508765008389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008390 dimerization interface [polypeptide binding]; other site 508765008391 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008392 dimer interface [polypeptide binding]; other site 508765008393 putative CheW interface [polypeptide binding]; other site 508765008394 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 508765008395 trimer interface [polypeptide binding]; other site 508765008396 active site 508765008397 substrate binding site [chemical binding]; other site 508765008398 CoA binding site [chemical binding]; other site 508765008399 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 508765008400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 508765008401 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 508765008402 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 508765008403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765008404 Walker A motif; other site 508765008405 ATP binding site [chemical binding]; other site 508765008406 Walker B motif; other site 508765008407 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 508765008408 synthetase active site [active] 508765008409 NTP binding site [chemical binding]; other site 508765008410 metal binding site [ion binding]; metal-binding site 508765008411 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 508765008412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 508765008413 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008415 dimer interface [polypeptide binding]; other site 508765008416 putative CheW interface [polypeptide binding]; other site 508765008417 Stage II sporulation protein; Region: SpoIID; pfam08486 508765008418 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 508765008419 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 508765008420 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 508765008421 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 508765008422 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 508765008423 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 508765008424 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 508765008425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 508765008426 putative active site [active] 508765008427 putative metal binding site [ion binding]; other site 508765008428 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 508765008429 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 508765008430 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 508765008431 active site 508765008432 HIGH motif; other site 508765008433 dimer interface [polypeptide binding]; other site 508765008434 KMSKS motif; other site 508765008435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508765008436 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 508765008437 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 508765008438 Spore germination protein; Region: Spore_permease; cl15802 508765008439 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 508765008440 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 508765008441 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 508765008442 active site 508765008443 HIGH motif; other site 508765008444 dimer interface [polypeptide binding]; other site 508765008445 KMSKS motif; other site 508765008446 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 508765008447 active site 508765008448 tetramer interface; other site 508765008449 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 508765008450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 508765008451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008452 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 508765008453 Bacterial sugar transferase; Region: Bac_transf; cl00939 508765008454 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 508765008455 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 508765008456 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008457 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008459 dimerization interface [polypeptide binding]; other site 508765008460 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 508765008461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765008462 dimer interface [polypeptide binding]; other site 508765008463 phosphorylation site [posttranslational modification] 508765008464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 508765008465 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765008466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765008467 active site 508765008468 phosphorylation site [posttranslational modification] 508765008469 intermolecular recognition site; other site 508765008470 dimerization interface [polypeptide binding]; other site 508765008471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765008472 DNA binding site [nucleotide binding] 508765008473 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 508765008474 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 508765008475 active site 508765008476 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 508765008477 homodimer interface [polypeptide binding]; other site 508765008478 O-Antigen ligase; Region: Wzy_C; cl04850 508765008479 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 508765008480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008481 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 508765008482 NAD(P) binding site [chemical binding]; other site 508765008483 homodimer interface [polypeptide binding]; other site 508765008484 substrate binding site [chemical binding]; other site 508765008485 active site 508765008486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508765008487 active site 508765008488 LicD family; Region: LicD; cl01378 508765008489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 508765008490 active site 508765008491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765008492 dimer interface [polypeptide binding]; other site 508765008493 conserved gate region; other site 508765008494 putative PBP binding loops; other site 508765008495 ABC-ATPase subunit interface; other site 508765008496 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 508765008497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765008498 dimer interface [polypeptide binding]; other site 508765008499 conserved gate region; other site 508765008500 putative PBP binding loops; other site 508765008501 ABC-ATPase subunit interface; other site 508765008502 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 508765008503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 508765008504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008505 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765008506 active site 508765008507 motif I; other site 508765008508 motif II; other site 508765008509 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765008510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765008511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 508765008512 PAS fold; Region: PAS_3; pfam08447 508765008513 putative active site [active] 508765008514 heme pocket [chemical binding]; other site 508765008515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765008516 metal binding site [ion binding]; metal-binding site 508765008517 active site 508765008518 I-site; other site 508765008519 EamA-like transporter family; Region: EamA; cl01037 508765008520 EamA-like transporter family; Region: EamA; cl01037 508765008521 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008522 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008523 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 508765008524 MatE; Region: MatE; cl10513 508765008525 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508765008526 active site 508765008527 metal-binding site 508765008528 Helix-turn-helix domains; Region: HTH; cl00088 508765008529 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 508765008530 active site 508765008531 metal-binding site 508765008532 Phosphotransferase enzyme family; Region: APH; pfam01636 508765008533 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 508765008534 active site 508765008535 ATP binding site [chemical binding]; other site 508765008536 substrate binding site [chemical binding]; other site 508765008537 dimer interface [polypeptide binding]; other site 508765008538 YcxB-like protein; Region: YcxB; pfam14317 508765008539 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008540 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008541 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008542 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765008543 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008544 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008545 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008546 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765008547 active site 508765008548 metal binding site [ion binding]; metal-binding site 508765008549 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765008550 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008551 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008552 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008553 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 508765008554 active site 508765008555 metal binding site [ion binding]; metal-binding site 508765008556 ATP cone domain; Region: ATP-cone; pfam03477 508765008557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008558 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 508765008559 active site 508765008560 motif I; other site 508765008561 motif II; other site 508765008562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765008563 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 508765008564 dimer interface [polypeptide binding]; other site 508765008565 pyridoxal binding site [chemical binding]; other site 508765008566 ATP binding site [chemical binding]; other site 508765008567 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765008568 catalytic residues [active] 508765008569 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 508765008570 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 508765008571 Cache domain; Region: Cache_1; pfam02743 508765008572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 508765008573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008575 dimer interface [polypeptide binding]; other site 508765008576 putative CheW interface [polypeptide binding]; other site 508765008577 putative oxidoreductase; Provisional; Region: PRK12831 508765008578 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 508765008579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008580 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 508765008581 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 508765008582 FAD binding pocket [chemical binding]; other site 508765008583 FAD binding motif [chemical binding]; other site 508765008584 phosphate binding motif [ion binding]; other site 508765008585 beta-alpha-beta structure motif; other site 508765008586 NAD binding pocket [chemical binding]; other site 508765008587 Iron coordination center [ion binding]; other site 508765008588 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 508765008589 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 508765008590 putative active site [active] 508765008591 metal binding site [ion binding]; metal-binding site 508765008592 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 508765008593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765008594 Walker A motif; other site 508765008595 ATP binding site [chemical binding]; other site 508765008596 Walker B motif; other site 508765008597 arginine finger; other site 508765008598 Helix-turn-helix domains; Region: HTH; cl00088 508765008599 3D domain; Region: 3D; cl01439 508765008600 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 508765008601 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 508765008602 G1 box; other site 508765008603 putative GEF interaction site [polypeptide binding]; other site 508765008604 GTP/Mg2+ binding site [chemical binding]; other site 508765008605 Switch I region; other site 508765008606 G2 box; other site 508765008607 G3 box; other site 508765008608 Switch II region; other site 508765008609 G4 box; other site 508765008610 G5 box; other site 508765008611 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 508765008612 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008613 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008614 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008615 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 508765008616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 508765008617 GAF domain; Region: GAF_2; pfam13185 508765008618 GAF domain; Region: GAF; cl15785 508765008619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 508765008620 metal binding site [ion binding]; metal-binding site 508765008621 active site 508765008622 I-site; other site 508765008623 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008624 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008625 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008626 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008627 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008628 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008629 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008630 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008631 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008632 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008633 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008634 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008635 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008636 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008637 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008638 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008639 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008640 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008641 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008642 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008643 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008644 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008645 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008646 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008647 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008648 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008649 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008650 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 508765008651 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008652 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008653 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008654 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008655 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008656 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008657 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008658 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008659 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008660 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 508765008661 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 508765008662 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 508765008663 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 508765008664 active site 508765008665 Zn binding site [ion binding]; other site 508765008666 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 508765008667 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 508765008668 active site 508765008669 ATP-grasp domain; Region: ATP-grasp_4; cl03087 508765008670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008671 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 508765008672 NAD(P) binding site [chemical binding]; other site 508765008673 active site 508765008674 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 508765008675 Ligand binding site; other site 508765008676 Putative Catalytic site; other site 508765008677 DXD motif; other site 508765008678 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 508765008679 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765008680 inhibitor-cofactor binding pocket; inhibition site 508765008681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008682 catalytic residue [active] 508765008683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008684 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 508765008685 Probable Catalytic site; other site 508765008686 metal-binding site 508765008687 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 508765008688 Probable Catalytic site; other site 508765008689 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 508765008690 metal-binding site 508765008691 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 508765008692 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 508765008693 Walker A/P-loop; other site 508765008694 ATP binding site [chemical binding]; other site 508765008695 Q-loop/lid; other site 508765008696 ABC transporter signature motif; other site 508765008697 Walker B; other site 508765008698 D-loop; other site 508765008699 H-loop/switch region; other site 508765008700 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 508765008701 putative carbohydrate binding site [chemical binding]; other site 508765008702 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765008703 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 508765008704 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 508765008705 NADP binding site [chemical binding]; other site 508765008706 active site 508765008707 putative substrate binding site [chemical binding]; other site 508765008708 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 508765008709 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 508765008710 Probable Catalytic site; other site 508765008711 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 508765008712 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 508765008713 NAD binding site [chemical binding]; other site 508765008714 substrate binding site [chemical binding]; other site 508765008715 homodimer interface [polypeptide binding]; other site 508765008716 active site 508765008717 Cupin domain; Region: Cupin_2; cl09118 508765008718 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 508765008719 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 508765008720 substrate binding site; other site 508765008721 tetramer interface; other site 508765008722 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 508765008723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765008724 Bacterial sugar transferase; Region: Bac_transf; cl00939 508765008725 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 508765008726 O-Antigen ligase; Region: Wzy_C; cl04850 508765008727 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 508765008728 O-Antigen ligase; Region: Wzy_C; cl04850 508765008729 Protein of unknown function DUF86; Region: DUF86; cl01031 508765008730 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008731 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008732 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008733 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008734 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008735 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765008736 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765008737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765008738 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 508765008739 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 508765008740 AP (apurinic/apyrimidinic) site pocket; other site 508765008741 DNA interaction; other site 508765008742 Metal-binding active site; metal-binding site 508765008743 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 508765008744 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 508765008745 intersubunit interface [polypeptide binding]; other site 508765008746 active site 508765008747 Zn2+ binding site [ion binding]; other site 508765008748 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 508765008749 P-loop; other site 508765008750 active site 508765008751 phosphorylation site [posttranslational modification] 508765008752 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 508765008753 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765008754 active site 508765008755 phosphorylation site [posttranslational modification] 508765008756 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765008757 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 508765008758 Helix-turn-helix domains; Region: HTH; cl00088 508765008759 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 508765008760 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 508765008761 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 508765008762 active site 508765008763 metal binding site [ion binding]; metal-binding site 508765008764 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 508765008765 Cation efflux family; Region: Cation_efflux; cl00316 508765008766 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 508765008767 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 508765008768 PYR/PP interface [polypeptide binding]; other site 508765008769 dimer interface [polypeptide binding]; other site 508765008770 TPP binding site [chemical binding]; other site 508765008771 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 508765008772 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 508765008773 TPP-binding site [chemical binding]; other site 508765008774 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 508765008775 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008777 dimer interface [polypeptide binding]; other site 508765008778 putative CheW interface [polypeptide binding]; other site 508765008779 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 508765008780 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 508765008781 Walker A/P-loop; other site 508765008782 ATP binding site [chemical binding]; other site 508765008783 Q-loop/lid; other site 508765008784 ABC transporter signature motif; other site 508765008785 Walker B; other site 508765008786 D-loop; other site 508765008787 H-loop/switch region; other site 508765008788 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 508765008789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 508765008790 dimer interface [polypeptide binding]; other site 508765008791 conserved gate region; other site 508765008792 putative PBP binding loops; other site 508765008793 ABC-ATPase subunit interface; other site 508765008794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 508765008795 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 508765008796 substrate binding pocket [chemical binding]; other site 508765008797 membrane-bound complex binding site; other site 508765008798 hinge residues; other site 508765008799 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 508765008800 Family description; Region: UvrD_C_2; cl15862 508765008801 FtsH Extracellular; Region: FtsH_ext; pfam06480 508765008802 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 508765008803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765008804 Walker A motif; other site 508765008805 ATP binding site [chemical binding]; other site 508765008806 Walker B motif; other site 508765008807 arginine finger; other site 508765008808 Peptidase family M41; Region: Peptidase_M41; pfam01434 508765008809 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 508765008810 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508765008811 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508765008812 Catalytic site [active] 508765008813 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 508765008814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 508765008815 Catalytic site [active] 508765008816 diaminopimelate decarboxylase; Region: lysA; TIGR01048 508765008817 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 508765008818 active site 508765008819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 508765008820 substrate binding site [chemical binding]; other site 508765008821 catalytic residues [active] 508765008822 dimer interface [polypeptide binding]; other site 508765008823 Lysine riboswitch 508765008824 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 508765008825 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 508765008826 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 508765008827 amidase catalytic site [active] 508765008828 Zn binding residues [ion binding]; other site 508765008829 substrate binding site [chemical binding]; other site 508765008830 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 508765008831 dimerization interface [polypeptide binding]; other site 508765008832 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008833 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008834 dimer interface [polypeptide binding]; other site 508765008835 putative CheW interface [polypeptide binding]; other site 508765008836 aspartate aminotransferase; Provisional; Region: PRK06836 508765008837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 508765008838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008839 homodimer interface [polypeptide binding]; other site 508765008840 catalytic residue [active] 508765008841 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 508765008842 metal ion-dependent adhesion site (MIDAS); other site 508765008843 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 508765008844 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 508765008845 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 508765008846 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 508765008847 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 508765008848 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 508765008849 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 508765008850 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 508765008851 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 508765008852 Walker A motif; other site 508765008853 ATP binding site [chemical binding]; other site 508765008854 Walker B motif; other site 508765008855 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 508765008856 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 508765008857 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 508765008858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765008859 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 508765008860 Walker A/P-loop; other site 508765008861 ATP binding site [chemical binding]; other site 508765008862 Q-loop/lid; other site 508765008863 ABC transporter signature motif; other site 508765008864 Walker B; other site 508765008865 D-loop; other site 508765008866 H-loop/switch region; other site 508765008867 Predicted transcriptional regulators [Transcription]; Region: COG1725 508765008868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 508765008869 DNA-binding site [nucleotide binding]; DNA binding site 508765008870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 508765008871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 508765008872 dimer interface [polypeptide binding]; other site 508765008873 putative CheW interface [polypeptide binding]; other site 508765008874 NMT1-like family; Region: NMT1_2; cl15260 508765008875 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 508765008876 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765008877 metal-binding site [ion binding] 508765008878 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765008879 metal-binding site [ion binding] 508765008880 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 508765008881 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 508765008882 metal-binding site [ion binding] 508765008883 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765008884 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765008885 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 508765008886 putative homotetramer interface [polypeptide binding]; other site 508765008887 putative homodimer interface [polypeptide binding]; other site 508765008888 putative allosteric switch controlling residues; other site 508765008889 putative metal binding site [ion binding]; other site 508765008890 putative homodimer-homodimer interface [polypeptide binding]; other site 508765008891 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 508765008892 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 508765008893 metal binding site [ion binding]; metal-binding site 508765008894 dimer interface [polypeptide binding]; other site 508765008895 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 508765008896 catalytic triad [active] 508765008897 Predicted amidohydrolase [General function prediction only]; Region: COG0388 508765008898 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 508765008899 putative active site [active] 508765008900 catalytic triad [active] 508765008901 putative dimer interface [polypeptide binding]; other site 508765008902 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508765008903 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 508765008904 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 508765008905 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 508765008906 dimer interface [polypeptide binding]; other site 508765008907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008908 catalytic residue [active] 508765008909 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 508765008910 cystathionine beta-lyase; Provisional; Region: PRK07671 508765008911 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 508765008912 homodimer interface [polypeptide binding]; other site 508765008913 substrate-cofactor binding pocket; other site 508765008914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765008915 catalytic residue [active] 508765008916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765008917 S-adenosylmethionine binding site [chemical binding]; other site 508765008918 T-box leader 508765008919 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 508765008920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 508765008921 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 508765008922 active site 508765008923 uracil binding [chemical binding]; other site 508765008924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765008925 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 508765008926 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 508765008927 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 508765008928 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 508765008929 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 508765008930 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 508765008931 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 508765008932 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 508765008933 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 508765008934 Ligand binding site; other site 508765008935 metal-binding site 508765008936 Helix-turn-helix domains; Region: HTH; cl00088 508765008937 TRAM domain; Region: TRAM; cl01282 508765008938 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 508765008939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765008940 S-adenosylmethionine binding site [chemical binding]; other site 508765008941 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765008942 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 508765008943 N- and C-terminal domain interface [polypeptide binding]; other site 508765008944 D-xylulose kinase; Region: XylB; TIGR01312 508765008945 active site 508765008946 catalytic site [active] 508765008947 metal binding site [ion binding]; metal-binding site 508765008948 xylulose binding site [chemical binding]; other site 508765008949 putative ATP binding site [chemical binding]; other site 508765008950 homodimer interface [polypeptide binding]; other site 508765008951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 508765008952 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 508765008953 inhibitor binding site; inhibition site 508765008954 catalytic Zn binding site [ion binding]; other site 508765008955 structural Zn binding site [ion binding]; other site 508765008956 NADP binding site [chemical binding]; other site 508765008957 tetramer interface [polypeptide binding]; other site 508765008958 Helix-turn-helix domains; Region: HTH; cl00088 508765008959 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508765008960 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765008961 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 508765008962 pyruvate kinase; Provisional; Region: PRK05826 508765008963 domain interfaces; other site 508765008964 active site 508765008965 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 508765008966 active site 508765008967 ADP/pyrophosphate binding site [chemical binding]; other site 508765008968 dimerization interface [polypeptide binding]; other site 508765008969 allosteric effector site; other site 508765008970 fructose-1,6-bisphosphate binding site; other site 508765008971 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 508765008972 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 508765008973 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 508765008974 generic binding surface II; other site 508765008975 generic binding surface I; other site 508765008976 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 508765008977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 508765008978 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 508765008979 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 508765008980 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 508765008981 putative substrate binding pocket [chemical binding]; other site 508765008982 dimer interface [polypeptide binding]; other site 508765008983 phosphate binding site [ion binding]; other site 508765008984 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 508765008985 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 508765008986 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 508765008987 FAD binding domain; Region: FAD_binding_4; pfam01565 508765008988 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 508765008989 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 508765008990 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 508765008991 GIY-YIG motif/motif A; other site 508765008992 active site 508765008993 catalytic site [active] 508765008994 putative DNA binding site [nucleotide binding]; other site 508765008995 metal binding site [ion binding]; metal-binding site 508765008996 UvrB/uvrC motif; Region: UVR; pfam02151 508765008997 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 508765008998 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 508765008999 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 508765009000 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 508765009001 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 508765009002 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 508765009003 phosphopeptide binding site; other site 508765009004 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 508765009005 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 508765009006 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 508765009007 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 508765009008 excinuclease ABC subunit B; Provisional; Region: PRK05298 508765009009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 508765009010 ATP binding site [chemical binding]; other site 508765009011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765009012 nucleotide binding region [chemical binding]; other site 508765009013 ATP-binding site [chemical binding]; other site 508765009014 Ultra-violet resistance protein B; Region: UvrB; pfam12344 508765009015 UvrB/uvrC motif; Region: UVR; pfam02151 508765009016 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 508765009017 protein binding site [polypeptide binding]; other site 508765009018 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 508765009019 C-terminal peptidase (prc); Region: prc; TIGR00225 508765009020 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 508765009021 protein binding site [polypeptide binding]; other site 508765009022 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 508765009023 Catalytic dyad [active] 508765009024 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 508765009025 FtsX-like permease family; Region: FtsX; cl15850 508765009026 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 508765009027 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 508765009028 Walker A/P-loop; other site 508765009029 ATP binding site [chemical binding]; other site 508765009030 Q-loop/lid; other site 508765009031 ABC transporter signature motif; other site 508765009032 Walker B; other site 508765009033 D-loop; other site 508765009034 H-loop/switch region; other site 508765009035 Uncharacterized conserved protein [Function unknown]; Region: COG1284 508765009036 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 508765009037 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 508765009038 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508765009039 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765009040 PYR/PP interface [polypeptide binding]; other site 508765009041 dimer interface [polypeptide binding]; other site 508765009042 TPP binding site [chemical binding]; other site 508765009043 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765009044 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508765009045 TPP-binding site [chemical binding]; other site 508765009046 dimer interface [polypeptide binding]; other site 508765009047 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 508765009048 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 508765009049 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 508765009050 active site 508765009051 phosphorylation site [posttranslational modification] 508765009052 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765009053 active pocket/dimerization site; other site 508765009054 active site 508765009055 phosphorylation site [posttranslational modification] 508765009056 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 508765009057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009058 Walker A motif; other site 508765009059 ATP binding site [chemical binding]; other site 508765009060 Walker B motif; other site 508765009061 arginine finger; other site 508765009062 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508765009063 PRD domain; Region: PRD; cl15445 508765009064 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 508765009065 active pocket/dimerization site; other site 508765009066 active site 508765009067 phosphorylation site [posttranslational modification] 508765009068 PRD domain; Region: PRD; cl15445 508765009069 PemK-like protein; Region: PemK; cl00995 508765009070 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 508765009071 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 508765009072 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 508765009073 putative substrate binding site [chemical binding]; other site 508765009074 putative ATP binding site [chemical binding]; other site 508765009075 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 508765009076 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765009077 dimer interface [polypeptide binding]; other site 508765009078 ssDNA binding site [nucleotide binding]; other site 508765009079 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765009080 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 508765009081 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 508765009082 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 508765009083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009084 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 508765009085 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 508765009086 putative trimer interface [polypeptide binding]; other site 508765009087 putative active site [active] 508765009088 putative substrate binding site [chemical binding]; other site 508765009089 putative CoA binding site [chemical binding]; other site 508765009090 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 508765009091 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 508765009092 inhibitor-cofactor binding pocket; inhibition site 508765009093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 508765009094 catalytic residue [active] 508765009095 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 508765009096 Predicted methyltransferases [General function prediction only]; Region: COG0313 508765009097 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 508765009098 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 508765009099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 508765009100 S-adenosylmethionine binding site [chemical binding]; other site 508765009101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 508765009102 NlpC/P60 family; Region: NLPC_P60; cl11438 508765009103 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 508765009104 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765009105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 508765009106 motif II; other site 508765009107 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 508765009108 PPIC-type PPIASE domain; Region: Rotamase; cl08278 508765009109 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 508765009110 ligand binding site [chemical binding]; other site 508765009111 active site 508765009112 UGI interface [polypeptide binding]; other site 508765009113 catalytic site [active] 508765009114 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 508765009115 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 508765009116 MPT binding site; other site 508765009117 trimer interface [polypeptide binding]; other site 508765009118 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 508765009119 Predicted transcriptional regulator [Transcription]; Region: COG2378 508765009120 Helix-turn-helix domains; Region: HTH; cl00088 508765009121 WYL domain; Region: WYL; cl14852 508765009122 NAD-dependent deacetylase; Provisional; Region: PRK00481 508765009123 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 508765009124 NAD+ binding site [chemical binding]; other site 508765009125 substrate binding site [chemical binding]; other site 508765009126 putative Zn binding site [ion binding]; other site 508765009127 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 508765009128 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 508765009129 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 508765009130 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 508765009131 E3 interaction surface; other site 508765009132 lipoyl attachment site [posttranslational modification]; other site 508765009133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009134 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 508765009135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 508765009136 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 508765009137 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 508765009138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765009139 Helix-turn-helix domains; Region: HTH; cl00088 508765009140 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 508765009141 CAAX protease self-immunity; Region: Abi; cl00558 508765009142 Competence-damaged protein; Region: CinA; cl00666 508765009143 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 508765009144 catalytic core [active] 508765009145 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 508765009146 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 508765009147 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 508765009148 elongation factor G; Reviewed; Region: PRK12740 508765009149 G1 box; other site 508765009150 putative GEF interaction site [polypeptide binding]; other site 508765009151 GTP/Mg2+ binding site [chemical binding]; other site 508765009152 Switch I region; other site 508765009153 G2 box; other site 508765009154 G3 box; other site 508765009155 Switch II region; other site 508765009156 G4 box; other site 508765009157 G5 box; other site 508765009158 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 508765009159 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 508765009160 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 508765009161 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 508765009162 Sulfatase; Region: Sulfatase; cl10460 508765009163 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 508765009164 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 508765009165 VanZ like family; Region: VanZ; cl01971 508765009166 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 508765009167 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 508765009168 ligand binding site; other site 508765009169 oligomer interface; other site 508765009170 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 508765009171 dimer interface [polypeptide binding]; other site 508765009172 N-terminal domain interface [polypeptide binding]; other site 508765009173 sulfate 1 binding site; other site 508765009174 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 508765009175 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 508765009176 ligand binding site; other site 508765009177 oligomer interface; other site 508765009178 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 508765009179 dimer interface [polypeptide binding]; other site 508765009180 N-terminal domain interface [polypeptide binding]; other site 508765009181 sulfate 1 binding site; other site 508765009182 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 508765009183 homodimer interface [polypeptide binding]; other site 508765009184 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765009185 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 508765009186 active site 508765009187 homodimer interface [polypeptide binding]; other site 508765009188 catalytic site [active] 508765009189 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 508765009190 homodimer interface [polypeptide binding]; other site 508765009191 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 508765009192 active site pocket [active] 508765009193 glycogen synthase; Provisional; Region: glgA; PRK00654 508765009194 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 508765009195 ADP-binding pocket [chemical binding]; other site 508765009196 homodimer interface [polypeptide binding]; other site 508765009197 glycogen branching enzyme; Provisional; Region: PRK12313 508765009198 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 508765009199 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 508765009200 active site 508765009201 catalytic site [active] 508765009202 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 508765009203 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 508765009204 HPr interaction site; other site 508765009205 glycerol kinase (GK) interaction site [polypeptide binding]; other site 508765009206 active site 508765009207 phosphorylation site [posttranslational modification] 508765009208 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765009209 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 508765009210 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765009211 active site turn [active] 508765009212 phosphorylation site [posttranslational modification] 508765009213 CAT RNA binding domain; Region: CAT_RBD; cl03904 508765009214 transcriptional antiterminator BglG; Provisional; Region: PRK09772 508765009215 PRD domain; Region: PRD; cl15445 508765009216 PRD domain; Region: PRD; cl15445 508765009217 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765009218 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 508765009219 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 508765009220 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 508765009221 flagellin; Provisional; Region: PRK12804 508765009222 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 508765009223 Global regulator protein family; Region: CsrA; cl00670 508765009224 Predicted membrane protein [Function unknown]; Region: COG1289 508765009225 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 508765009226 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 508765009227 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 508765009228 putative ATP binding site [chemical binding]; other site 508765009229 putative substrate interface [chemical binding]; other site 508765009230 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 508765009231 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009232 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009233 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009234 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009235 YibE/F-like protein; Region: YibE_F; cl02259 508765009236 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 508765009237 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 508765009238 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 508765009239 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 508765009240 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 508765009241 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 508765009242 generic binding surface II; other site 508765009243 generic binding surface I; other site 508765009244 Cupin domain; Region: Cupin_2; cl09118 508765009245 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 508765009246 Domain of unknown function DUF21; Region: DUF21; pfam01595 508765009247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 508765009248 Transporter associated domain; Region: CorC_HlyC; cl08393 508765009249 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 508765009250 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 508765009251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009252 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 508765009253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765009254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765009255 catalytic residue [active] 508765009256 chromosome segregation protein; Provisional; Region: PRK03918 508765009257 ABC-2 type transporter; Region: ABC2_membrane; cl11417 508765009258 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 508765009259 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765009260 Walker A/P-loop; other site 508765009261 ATP binding site [chemical binding]; other site 508765009262 Q-loop/lid; other site 508765009263 ABC transporter signature motif; other site 508765009264 Walker B; other site 508765009265 D-loop; other site 508765009266 H-loop/switch region; other site 508765009267 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 508765009268 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 508765009269 recombination protein RecR; Reviewed; Region: recR; PRK00076 508765009270 RecR protein; Region: RecR; pfam02132 508765009271 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 508765009272 putative active site [active] 508765009273 putative metal-binding site [ion binding]; other site 508765009274 tetramer interface [polypeptide binding]; other site 508765009275 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 508765009276 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 508765009277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009278 Walker A motif; other site 508765009279 ATP binding site [chemical binding]; other site 508765009280 Walker B motif; other site 508765009281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765009282 arginine finger; other site 508765009283 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 508765009284 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 508765009285 dimerization interface [polypeptide binding]; other site 508765009286 active site 508765009287 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 508765009288 folate binding site [chemical binding]; other site 508765009289 NADP+ binding site [chemical binding]; other site 508765009290 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 508765009291 active site 508765009292 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 508765009293 nucleoside/Zn binding site; other site 508765009294 dimer interface [polypeptide binding]; other site 508765009295 catalytic motif [active] 508765009296 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 508765009297 Domain of unknown function DUF21; Region: DUF21; pfam01595 508765009298 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 508765009299 Transporter associated domain; Region: CorC_HlyC; cl08393 508765009300 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 508765009301 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 508765009302 putative substrate binding site [chemical binding]; other site 508765009303 putative ATP binding site [chemical binding]; other site 508765009304 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 508765009305 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 508765009306 substrate binding [chemical binding]; other site 508765009307 active site 508765009308 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 508765009309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 508765009310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 508765009311 DNA binding site [nucleotide binding] 508765009312 domain linker motif; other site 508765009313 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 508765009314 dimerization interface [polypeptide binding]; other site 508765009315 ligand binding site [chemical binding]; other site 508765009316 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 508765009317 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 508765009318 active site turn [active] 508765009319 phosphorylation site [posttranslational modification] 508765009320 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 508765009321 Leucine carboxyl methyltransferase; Region: LCM; cl01306 508765009322 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 508765009323 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765009324 Walker A/P-loop; other site 508765009325 ATP binding site [chemical binding]; other site 508765009326 Q-loop/lid; other site 508765009327 ABC transporter signature motif; other site 508765009328 Walker B; other site 508765009329 D-loop; other site 508765009330 H-loop/switch region; other site 508765009331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765009332 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 508765009333 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 508765009334 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 508765009335 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 508765009336 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 508765009337 putative acyl-acceptor binding pocket; other site 508765009338 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 508765009339 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765009340 ATP binding site [chemical binding]; other site 508765009341 Mg++ binding site [ion binding]; other site 508765009342 motif III; other site 508765009343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765009344 nucleotide binding region [chemical binding]; other site 508765009345 ATP-binding site [chemical binding]; other site 508765009346 DbpA RNA binding domain; Region: DbpA; pfam03880 508765009347 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 508765009348 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 508765009349 putative dimer interface [polypeptide binding]; other site 508765009350 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 508765009351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 508765009352 Phosphotransferase enzyme family; Region: APH; pfam01636 508765009353 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 508765009354 active site 508765009355 ATP binding site [chemical binding]; other site 508765009356 substrate binding site [chemical binding]; other site 508765009357 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 508765009358 hypothetical protein; Provisional; Region: PRK06851 508765009359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009360 Walker A motif; other site 508765009361 ATP binding site [chemical binding]; other site 508765009362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765009363 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 508765009364 Sulfate transporter family; Region: Sulfate_transp; cl15842 508765009365 Sulfate transporter family; Region: Sulfate_transp; cl15842 508765009366 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 508765009367 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 508765009368 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 508765009369 dimer interface [polypeptide binding]; other site 508765009370 active site 508765009371 catalytic residue [active] 508765009372 Lysine riboswitch 508765009373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765009374 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 508765009375 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 508765009376 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 508765009377 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 508765009378 active site 508765009379 nucleophile elbow; other site 508765009380 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 508765009381 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 508765009382 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 508765009383 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 508765009384 G1 box; other site 508765009385 GTP/Mg2+ binding site [chemical binding]; other site 508765009386 Switch I region; other site 508765009387 G2 box; other site 508765009388 Switch II region; other site 508765009389 G3 box; other site 508765009390 G4 box; other site 508765009391 G5 box; other site 508765009392 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 508765009393 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 508765009394 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 508765009395 ligand binding site [chemical binding]; other site 508765009396 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 508765009397 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 508765009398 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 508765009399 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 508765009400 NAD binding site [chemical binding]; other site 508765009401 dimer interface [polypeptide binding]; other site 508765009402 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765009403 substrate binding site [chemical binding]; other site 508765009404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 508765009405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 508765009406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765009407 ATP binding site [chemical binding]; other site 508765009408 Mg2+ binding site [ion binding]; other site 508765009409 G-X-G motif; other site 508765009410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765009411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765009412 active site 508765009413 phosphorylation site [posttranslational modification] 508765009414 intermolecular recognition site; other site 508765009415 dimerization interface [polypeptide binding]; other site 508765009416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765009417 DNA binding site [nucleotide binding] 508765009418 FtsX-like permease family; Region: FtsX; cl15850 508765009419 FtsX-like permease family; Region: FtsX; cl15850 508765009420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 508765009421 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 508765009422 Walker A/P-loop; other site 508765009423 ATP binding site [chemical binding]; other site 508765009424 Q-loop/lid; other site 508765009425 ABC transporter signature motif; other site 508765009426 Walker B; other site 508765009427 D-loop; other site 508765009428 H-loop/switch region; other site 508765009429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 508765009430 Helix-turn-helix domains; Region: HTH; cl00088 508765009431 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 508765009432 catalytic residues [active] 508765009433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 508765009434 Zn2+ binding site [ion binding]; other site 508765009435 Mg2+ binding site [ion binding]; other site 508765009436 TIGR03987 family protein; Region: TIGR03987 508765009437 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 508765009438 Helix-turn-helix domains; Region: HTH; cl00088 508765009439 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 508765009440 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 508765009441 PYR/PP interface [polypeptide binding]; other site 508765009442 dimer interface [polypeptide binding]; other site 508765009443 TPP binding site [chemical binding]; other site 508765009444 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 508765009445 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 508765009446 TPP-binding site [chemical binding]; other site 508765009447 dimer interface [polypeptide binding]; other site 508765009448 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 508765009449 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 508765009450 P-loop; other site 508765009451 active site 508765009452 phosphorylation site [posttranslational modification] 508765009453 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765009454 active site 508765009455 phosphorylation site [posttranslational modification] 508765009456 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 508765009457 Helix-turn-helix domains; Region: HTH; cl00088 508765009458 PRD domain; Region: PRD; cl15445 508765009459 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 508765009460 P-loop; other site 508765009461 active site 508765009462 phosphorylation site [posttranslational modification] 508765009463 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 508765009464 active site 508765009465 phosphorylation site [posttranslational modification] 508765009466 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 508765009467 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 508765009468 Ca binding site [ion binding]; other site 508765009469 active site 508765009470 catalytic site [active] 508765009471 Cupin domain; Region: Cupin_2; cl09118 508765009472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765009473 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 508765009474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 508765009475 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 508765009476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 508765009477 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 508765009478 DNA binding residues [nucleotide binding] 508765009479 Phosphate transporter family; Region: PHO4; cl00396 508765009480 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 508765009481 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 508765009482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 508765009483 dimer interface [polypeptide binding]; other site 508765009484 phosphorylation site [posttranslational modification] 508765009485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 508765009486 ATP binding site [chemical binding]; other site 508765009487 Mg2+ binding site [ion binding]; other site 508765009488 G-X-G motif; other site 508765009489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 508765009490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 508765009491 active site 508765009492 phosphorylation site [posttranslational modification] 508765009493 intermolecular recognition site; other site 508765009494 dimerization interface [polypeptide binding]; other site 508765009495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 508765009496 DNA binding site [nucleotide binding] 508765009497 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 508765009498 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 508765009499 active site 508765009500 catalytic site [active] 508765009501 metal binding site [ion binding]; metal-binding site 508765009502 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 508765009503 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 508765009504 ATP binding site [chemical binding]; other site 508765009505 Mg++ binding site [ion binding]; other site 508765009506 motif III; other site 508765009507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 508765009508 nucleotide binding region [chemical binding]; other site 508765009509 ATP-binding site [chemical binding]; other site 508765009510 Probable zinc-binding domain; Region: zf-trcl; pfam13451 508765009511 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 508765009512 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 508765009513 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 508765009514 hypothetical protein; Provisional; Region: PRK05590 508765009515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765009516 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 508765009517 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 508765009518 hinge; other site 508765009519 active site 508765009520 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 508765009521 Protein of unknown function, DUF606; Region: DUF606; cl01273 508765009522 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 508765009523 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 508765009524 active site 508765009525 catalytic residues [active] 508765009526 G5 domain; Region: G5; pfam07501 508765009527 Peptidase family M23; Region: Peptidase_M23; pfam01551 508765009528 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765009529 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 508765009530 DNA replication protein DnaC; Validated; Region: PRK06835 508765009531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765009532 Walker A motif; other site 508765009533 ATP binding site [chemical binding]; other site 508765009534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009535 flavoprotein, HI0933 family; Region: TIGR00275 508765009536 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 508765009537 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 508765009538 active site 508765009539 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 508765009540 active site 2 [active] 508765009541 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 508765009542 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 508765009543 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 508765009544 GDP-binding site [chemical binding]; other site 508765009545 ACT binding site; other site 508765009546 IMP binding site; other site 508765009547 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 508765009548 Malic enzyme, N-terminal domain; Region: malic; pfam00390 508765009549 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 508765009550 putative NAD(P) binding site [chemical binding]; other site 508765009551 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 508765009552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009553 replicative DNA helicase; Provisional; Region: PRK05595 508765009554 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 508765009555 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 508765009556 Walker A motif; other site 508765009557 ATP binding site [chemical binding]; other site 508765009558 Walker B motif; other site 508765009559 DNA binding loops [nucleotide binding] 508765009560 ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903 508765009561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 508765009562 Walker A motif; other site 508765009563 ATP binding site [chemical binding]; other site 508765009564 Walker B motif; other site 508765009565 arginine finger; other site 508765009566 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 508765009567 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 508765009568 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 508765009569 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 508765009570 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 508765009571 DHH family; Region: DHH; pfam01368 508765009572 DHHA1 domain; Region: DHHA1; pfam02272 508765009573 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 508765009574 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 508765009575 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 508765009576 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765009577 dimer interface [polypeptide binding]; other site 508765009578 ssDNA binding site [nucleotide binding]; other site 508765009579 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765009580 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 508765009581 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 508765009582 Mechanosensitive ion channel; Region: MS_channel; pfam00924 508765009583 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 508765009584 LysE type translocator; Region: LysE; cl00565 508765009585 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 508765009586 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 508765009587 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 508765009588 catalytic residue [active] 508765009589 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 508765009590 ParB-like nuclease domain; Region: ParBc; cl02129 508765009591 ParB-like partition proteins; Region: parB_part; TIGR00180 508765009592 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 508765009593 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765009594 P-loop; other site 508765009595 Magnesium ion binding site [ion binding]; other site 508765009596 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 508765009597 Magnesium ion binding site [ion binding]; other site 508765009598 ParB-like nuclease domain; Region: ParBc; cl02129 508765009599 ParB-like partition proteins; Region: parB_part; TIGR00180 508765009600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765009601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 508765009602 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 508765009603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 508765009604 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 508765009605 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 508765009606 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 508765009607 trmE is a tRNA modification GTPase; Region: trmE; cd04164 508765009608 G1 box; other site 508765009609 GTP/Mg2+ binding site [chemical binding]; other site 508765009610 Switch I region; other site 508765009611 G2 box; other site 508765009612 Switch II region; other site 508765009613 G3 box; other site 508765009614 G4 box; other site 508765009615 G5 box; other site 508765009616 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 508765009617 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 508765009618 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 508765009619 G-X-X-G motif; other site 508765009620 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 508765009621 RxxxH motif; other site 508765009622 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 508765009623 Ribonuclease P; Region: Ribonuclease_P; cl00457 508765009624 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 508765009625 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 508765009626 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009627 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 508765009628 Walker A motif; other site 508765009629 ATP binding site [chemical binding]; other site 508765009630 Walker B motif; other site 508765009631 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 508765009632 AAA-like domain; Region: AAA_10; pfam12846 508765009633 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 508765009634 NlpC/P60 family; Region: NLPC_P60; cl11438 508765009635 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 508765009636 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 508765009637 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 508765009638 dimer interface [polypeptide binding]; other site 508765009639 ssDNA binding site [nucleotide binding]; other site 508765009640 tetramer (dimer of dimers) interface [polypeptide binding]; other site 508765009641 Clostridium enterotoxin; Region: Clenterotox; pfam03505 508765009642 Clostridium enterotoxin; Region: Clenterotox; pfam03505 508765009643 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 508765009644 Ricin-type beta-trefoil; Region: RICIN; smart00458 508765009645 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 508765009646 Ricin-type beta-trefoil; Region: RICIN; smart00458 508765009647 putative sugar binding sites [chemical binding]; other site 508765009648 Q-X-W motif; other site 508765009649 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 508765009650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765009651 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 508765009652 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 508765009653 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 508765009654 Nontoxic nonhaemagglutinin C-terminal; Region: NTNH_C; pfam08470 508765009655 Clostridial neurotoxin zinc protease; Region: Peptidase_M27; pfam01742 508765009656 Clostridium neurotoxin, Translocation domain; Region: Toxin_trans; pfam07952 508765009657 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 508765009658 Clostridium neurotoxin, C-terminal receptor binding; Region: Toxin_R_bind_C; pfam07951 508765009659 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 508765009660 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508765009661 catalytic residues [active] 508765009662 catalytic nucleophile [active] 508765009663 Presynaptic Site I dimer interface [polypeptide binding]; other site 508765009664 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508765009665 Synaptic Flat tetramer interface [polypeptide binding]; other site 508765009666 Synaptic Site I dimer interface [polypeptide binding]; other site 508765009667 DNA binding site [nucleotide binding] 508765009668 Helix-turn-helix domains; Region: HTH; cl00088 508765009669 multiple promoter invertase; Provisional; Region: mpi; PRK13413 508765009670 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 508765009671 catalytic residues [active] 508765009672 catalytic nucleophile [active] 508765009673 Presynaptic Site I dimer interface [polypeptide binding]; other site 508765009674 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 508765009675 Synaptic Flat tetramer interface [polypeptide binding]; other site 508765009676 Synaptic Site I dimer interface [polypeptide binding]; other site 508765009677 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 508765009678 DNA-binding interface [nucleotide binding]; DNA binding site 508765009679 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 508765009680 plasmid segregation protein ParM; Provisional; Region: PRK13917 508765009681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765009682 non-specific DNA binding site [nucleotide binding]; other site 508765009683 salt bridge; other site 508765009684 sequence-specific DNA binding site [nucleotide binding]; other site 508765009685 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 508765009686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765009687 non-specific DNA binding site [nucleotide binding]; other site 508765009688 salt bridge; other site 508765009689 sequence-specific DNA binding site [nucleotide binding]; other site 508765009690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 508765009691 non-specific DNA binding site [nucleotide binding]; other site 508765009692 salt bridge; other site 508765009693 sequence-specific DNA binding site [nucleotide binding]; other site 508765009694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 508765009695 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009696 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 508765009697 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009698 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009699 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 508765009700 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473