-- dump date 20120504_142241 -- class Genbank::misc_feature -- table misc_feature_note -- id note 699034000001 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 699034000002 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 699034000003 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 699034000004 Phage XkdN-like protein; Region: XkdN; pfam08890 699034000005 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 699034000006 Phage-related protein [Function unknown]; Region: COG5412 699034000007 reticulocyte binding protein 2-like protein; Provisional; Region: PTZ00440 699034000008 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 699034000009 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 699034000010 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 699034000011 NlpC/P60 family; Region: NLPC_P60; cl11438 699034000012 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 699034000013 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 699034000014 Baseplate J-like protein; Region: Baseplate_J; cl01294 699034000015 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 699034000016 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 699034000017 Holin family; Region: Phage_holin_4; cl01989 699034000018 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034000019 active site 699034000020 metal binding site [ion binding]; metal-binding site 699034000021 potential frameshift: common BLAST hit: gi|299769744|ref|YP_003731770.1| phage DNA methylase 699034000022 Helix-turn-helix domains; Region: HTH; cl00088 699034000023 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 699034000024 GIY-YIG motif/motif A; other site 699034000025 active site 699034000026 catalytic site [active] 699034000027 metal binding site [ion binding]; metal-binding site 699034000028 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 699034000029 GIY-YIG motif/motif A; other site 699034000030 active site 699034000031 catalytic site [active] 699034000032 metal binding site [ion binding]; metal-binding site 699034000033 Initiator Replication protein; Region: Rep_3; cl03080 699034000034 Helix-turn-helix domains; Region: HTH; cl00088 699034000035 Helix-turn-helix domains; Region: HTH; cl00088 699034000036 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 699034000037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034000038 non-specific DNA binding site [nucleotide binding]; other site 699034000039 salt bridge; other site 699034000040 sequence-specific DNA binding site [nucleotide binding]; other site 699034000041 Helix-turn-helix domains; Region: HTH; cl00088 699034000042 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 699034000043 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 699034000044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000045 Walker A motif; other site 699034000046 ATP binding site [chemical binding]; other site 699034000047 Walker B motif; other site 699034000048 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 699034000049 dimer interface [polypeptide binding]; other site 699034000050 ssDNA binding site [nucleotide binding]; other site 699034000051 tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034000052 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 699034000053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034000054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034000055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034000056 active site 699034000057 DNA binding site [nucleotide binding] 699034000058 Int/Topo IB signature motif; other site 699034000059 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 699034000060 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 699034000061 DNA-binding interface [nucleotide binding]; DNA binding site 699034000062 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 699034000063 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 699034000064 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 699034000065 peptidyl-tRNA hydrolase; Provisional; Region: PRK04322 699034000066 dimer interface [polypeptide binding]; other site 699034000067 putative active site [active] 699034000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 699034000069 NlpC/P60 family; Region: NLPC_P60; cl11438 699034000070 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 699034000071 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 699034000072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034000073 FeS/SAM binding site; other site 699034000074 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 699034000075 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 699034000076 ligand binding surface [chemical binding]; other site 699034000077 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 699034000078 ligand binding surface [chemical binding]; other site 699034000079 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 699034000080 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 699034000081 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 699034000082 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 699034000083 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000084 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000085 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 699034000086 activation loop (A-loop); other site 699034000087 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000088 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000089 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000090 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000091 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000092 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 699034000093 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 699034000094 Catalytic site [active] 699034000095 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 699034000096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000097 Family description; Region: UvrD_C_2; cl15862 699034000098 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 699034000099 radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X 699034000100 FtsH Extracellular; Region: FtsH_ext; pfam06480 699034000101 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 699034000102 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034000103 Walker A motif; other site 699034000104 ATP binding site [chemical binding]; other site 699034000105 Walker B motif; other site 699034000106 arginine finger; other site 699034000107 Peptidase family M41; Region: Peptidase_M41; pfam01434 699034000108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034000109 non-specific DNA binding site [nucleotide binding]; other site 699034000110 salt bridge; other site 699034000111 sequence-specific DNA binding site [nucleotide binding]; other site 699034000112 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 699034000113 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 699034000114 nucleotide binding pocket [chemical binding]; other site 699034000115 K-X-D-G motif; other site 699034000116 catalytic site [active] 699034000117 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 699034000118 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 699034000119 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 699034000120 Dimer interface [polypeptide binding]; other site 699034000121 BRCT sequence motif; other site 699034000122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034000123 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 699034000124 active site 699034000125 DNA binding site [nucleotide binding] 699034000126 Int/Topo IB signature motif; other site 699034000127 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000128 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000129 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000130 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 699034000131 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000132 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000133 Probable transposase; Region: OrfB_IS605; pfam01385 699034000134 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034000135 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 699034000136 Helix-turn-helix domains; Region: HTH; cl00088 699034000137 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 699034000138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000139 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 699034000140 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 699034000141 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 699034000142 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 699034000143 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 699034000144 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 699034000145 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034000146 Probable transposase; Region: OrfB_IS605; pfam01385 699034000147 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 699034000148 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 699034000149 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 699034000150 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 699034000151 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034000153 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000154 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000155 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000156 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000157 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000158 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000159 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000160 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000161 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000162 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000163 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000164 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000165 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000166 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000167 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000168 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000169 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000170 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000171 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000172 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000173 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000174 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000175 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000176 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000177 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000178 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 699034000179 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000180 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000181 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000182 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000183 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000184 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000185 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000186 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000187 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000188 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000189 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034000190 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000191 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000192 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000193 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034000195 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034000196 Probable transposase; Region: OrfB_IS605; pfam01385 699034000197 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034000198 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 699034000199 DNA binding residues [nucleotide binding] 699034000200 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 699034000201 catalytic residues [active] 699034000202 catalytic nucleophile [active] 699034000203 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000204 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000205 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000206 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000207 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000208 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000209 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000210 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000211 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000212 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000213 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000214 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000215 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000216 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000217 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000218 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000219 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000220 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000221 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000222 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000223 potential frameshift: common BLAST hit: gi|302391857|ref|YP_003827677.1| HNH endonuclease 699034000224 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000225 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000226 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000227 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000228 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000229 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000230 Protein of unknown function (DUF342); Region: DUF342; pfam03961 699034000231 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000232 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000233 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000234 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000235 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000236 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000237 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000238 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000239 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000240 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000241 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000242 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000243 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000244 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000245 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000246 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000247 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000248 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000249 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000250 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000251 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000252 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000253 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000254 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000255 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 699034000256 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 699034000257 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 699034000258 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000259 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000260 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000261 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000262 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000263 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000264 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000265 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034000267 non-specific DNA binding site [nucleotide binding]; other site 699034000268 salt bridge; other site 699034000269 sequence-specific DNA binding site [nucleotide binding]; other site 699034000270 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000271 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000272 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000273 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000274 aminoacyl-tRNA ligase; Region: PLN02959 699034000275 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000276 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000277 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000278 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000279 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000280 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000281 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000282 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000283 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000284 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000285 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000286 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000287 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000288 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000289 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000290 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000291 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000292 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000293 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000294 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000295 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000296 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000297 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000298 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000299 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000300 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000301 potential frameshift: common BLAST hit: gi|302391857|ref|YP_003827677.1| HNH endonuclease 699034000302 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000303 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000304 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000305 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000306 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000307 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000308 Cdc14 phosphatase binding protein N-terminus; Region: Cytokin_check_N; pfam10407 699034000309 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 699034000310 HerA helicase [Replication, recombination, and repair]; Region: COG0433 699034000311 Domain of unknown function DUF87; Region: DUF87; pfam01935 699034000312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034000313 S-adenosylmethionine binding site [chemical binding]; other site 699034000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034000315 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 699034000316 active site 699034000317 NTP binding site [chemical binding]; other site 699034000318 metal binding triad [ion binding]; metal-binding site 699034000319 AAA-like domain; Region: AAA_10; pfam12846 699034000320 Domain of unknown function DUF87; Region: DUF87; pfam01935 699034000321 PrgI family protein; Region: PrgI; pfam12666 699034000322 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 699034000323 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034000324 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034000325 DNA binding residues [nucleotide binding] 699034000326 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 699034000327 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 699034000328 metal ion-dependent adhesion site (MIDAS); other site 699034000329 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 699034000330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034000331 FtsX-like permease family; Region: FtsX; cl15850 699034000332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034000333 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034000334 Walker A/P-loop; other site 699034000335 ATP binding site [chemical binding]; other site 699034000336 Q-loop/lid; other site 699034000337 ABC transporter signature motif; other site 699034000338 Walker B; other site 699034000339 D-loop; other site 699034000340 H-loop/switch region; other site 699034000341 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 699034000342 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 699034000343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034000344 active site 699034000345 phosphorylation site [posttranslational modification] 699034000346 intermolecular recognition site; other site 699034000347 dimerization interface [polypeptide binding]; other site 699034000348 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000349 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 699034000350 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 699034000351 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 699034000352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000353 plasmid segregation protein ParM; Provisional; Region: PRK13917 699034000354 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 699034000355 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 699034000356 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 699034000357 generic binding surface I; other site 699034000358 generic binding surface II; other site 699034000359 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 699034000360 metal ion-dependent adhesion site (MIDAS); other site 699034000361 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 699034000362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000363 DNA primase, catalytic core; Region: dnaG; TIGR01391 699034000364 CHC2 zinc finger; Region: zf-CHC2; cl15369 699034000365 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 699034000366 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 699034000367 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 699034000368 potential frameshift: common BLAST hit: gi|18310965|ref|NP_562899.1| DNA topoisomerase 699034000369 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 699034000370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000371 Family description; Region: UvrD_C_2; cl15862 699034000372 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 699034000373 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034000374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000375 AAA-like domain; Region: AAA_10; pfam12846 699034000376 Walker A motif; other site 699034000377 ATP binding site [chemical binding]; other site 699034000378 Walker B motif; other site 699034000379 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cl00250 699034000380 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034000381 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 699034000382 active site 699034000383 metal binding site [ion binding]; metal-binding site 699034000384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000385 Walker A/P-loop; other site 699034000386 ATP binding site [chemical binding]; other site 699034000387 Transglycosylase; Region: Transgly; cl07896 699034000388 Transglycosylase; Region: Transgly; cl07896 699034000389 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 699034000390 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034000391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 699034000392 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 699034000393 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000394 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000395 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000396 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000397 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000398 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000399 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000400 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000401 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000402 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000403 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034000404 Domain of unknown function (DUF955); Region: DUF955; cl01076 699034000405 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 699034000406 DnaA N-terminal domain; Region: DnaA_N; pfam11638 699034000407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034000408 Walker A motif; other site 699034000409 ATP binding site [chemical binding]; other site 699034000410 Walker B motif; other site 699034000411 arginine finger; other site 699034000412 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 699034000413 DnaA box-binding interface [nucleotide binding]; other site 699034000414 DNA polymerase III subunit beta; Validated; Region: PRK05643 699034000415 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 699034000416 putative DNA binding surface [nucleotide binding]; other site 699034000417 dimer interface [polypeptide binding]; other site 699034000418 beta-clamp/clamp loader binding surface; other site 699034000419 beta-clamp/translesion DNA polymerase binding surface; other site 699034000420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 699034000421 RNA binding surface [nucleotide binding]; other site 699034000422 recombination protein F; Reviewed; Region: recF; PRK00064 699034000423 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 699034000424 Walker A/P-loop; other site 699034000425 ATP binding site [chemical binding]; other site 699034000426 Q-loop/lid; other site 699034000427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000428 ABC transporter signature motif; other site 699034000429 Walker B; other site 699034000430 D-loop; other site 699034000431 H-loop/switch region; other site 699034000432 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 699034000433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034000434 Mg2+ binding site [ion binding]; other site 699034000435 G-X-G motif; other site 699034000436 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 699034000437 anchoring element; other site 699034000438 dimer interface [polypeptide binding]; other site 699034000439 ATP binding site [chemical binding]; other site 699034000440 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 699034000441 active site 699034000442 putative metal-binding site [ion binding]; other site 699034000443 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 699034000444 DNA gyrase subunit A; Validated; Region: PRK05560 699034000445 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 699034000446 CAP-like domain; other site 699034000447 active site 699034000448 primary dimer interface [polypeptide binding]; other site 699034000449 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 699034000450 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 699034000451 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 699034000452 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 699034000453 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 699034000454 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 699034000455 YtxH-like protein; Region: YtxH; cl02079 699034000456 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 699034000457 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 699034000458 anti sigma factor interaction site; other site 699034000459 regulatory phosphorylation site [posttranslational modification]; other site 699034000460 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 699034000461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034000462 ATP binding site [chemical binding]; other site 699034000463 Mg2+ binding site [ion binding]; other site 699034000464 G-X-G motif; other site 699034000465 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 699034000466 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034000467 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 699034000468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034000469 potential RNA of insufficient length (23S ribosomal RNA) 699034000470 potential RNA of insufficient length (23S ribosomal RNA) 699034000471 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 699034000472 Helix-turn-helix domains; Region: HTH; cl00088 699034000473 3H domain; Region: 3H; pfam02829 699034000474 Mechanosensitive ion channel; Region: MS_channel; pfam00924 699034000475 seryl-tRNA synthetase; Provisional; Region: PRK05431 699034000476 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 699034000477 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 699034000478 dimer interface [polypeptide binding]; other site 699034000479 active site 699034000480 motif 1; other site 699034000481 motif 2; other site 699034000482 motif 3; other site 699034000483 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 699034000484 nucleoside/Zn binding site; other site 699034000485 dimer interface [polypeptide binding]; other site 699034000486 catalytic motif [active] 699034000487 potential protein location (hypothetical protein CDBI1_00080 [Clostridium difficile BI1]) that overlaps RNA (tRNA-S) 699034000488 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 699034000489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034000490 Walker A motif; other site 699034000491 ATP binding site [chemical binding]; other site 699034000492 Walker B motif; other site 699034000493 arginine finger; other site 699034000494 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 699034000495 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 699034000496 recombination protein RecR; Reviewed; Region: recR; PRK00076 699034000497 RecR protein; Region: RecR; pfam02132 699034000498 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 699034000499 putative active site [active] 699034000500 putative metal-binding site [ion binding]; other site 699034000501 tetramer interface [polypeptide binding]; other site 699034000502 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 699034000503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 699034000504 potential RNA of insufficient length (23S ribosomal RNA) 699034000505 potential protein location (hypothetical protein CDBI1_00110 [Clostridium difficile BI1]) that overlaps RNA (tRNA-L) 699034000506 pyruvate carboxylase; Reviewed; Region: PRK12999 699034000507 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 699034000508 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034000509 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 699034000510 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 699034000511 active site 699034000512 catalytic residues [active] 699034000513 metal binding site [ion binding]; metal-binding site 699034000514 homodimer binding site [polypeptide binding]; other site 699034000515 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 699034000516 carboxyltransferase (CT) interaction site; other site 699034000517 biotinylation site [posttranslational modification]; other site 699034000518 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000519 elongation factor G; Reviewed; Region: PRK12740 699034000520 G1 box; other site 699034000521 GTP/Mg2+ binding site [chemical binding]; other site 699034000522 G2 box; other site 699034000523 Switch I region; other site 699034000524 G3 box; other site 699034000525 Switch II region; other site 699034000526 G4 box; other site 699034000527 G5 box; other site 699034000528 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 699034000529 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 699034000530 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 699034000531 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 699034000532 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 699034000533 UvrB/uvrC motif; Region: UVR; pfam02151 699034000534 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 699034000535 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 699034000536 ADP binding site [chemical binding]; other site 699034000537 phosphagen binding site; other site 699034000538 substrate specificity loop; other site 699034000539 Clp protease ATP binding subunit; Region: clpC; CHL00095 699034000540 Clp amino terminal domain; Region: Clp_N; pfam02861 699034000541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034000542 Walker A motif; other site 699034000543 ATP binding site [chemical binding]; other site 699034000544 Walker B motif; other site 699034000545 arginine finger; other site 699034000546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034000547 Walker A motif; other site 699034000548 ATP binding site [chemical binding]; other site 699034000549 Walker B motif; other site 699034000550 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 699034000551 DNA repair protein RadA; Provisional; Region: PRK11823 699034000552 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 699034000553 Walker A motif/ATP binding site; other site 699034000554 ATP binding site [chemical binding]; other site 699034000555 Walker B motif; other site 699034000556 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 699034000557 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 699034000558 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 699034000559 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 699034000560 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 699034000561 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 699034000562 putative active site [active] 699034000563 Cupin domain; Region: Cupin_2; cl09118 699034000564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034000565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034000566 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 699034000567 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 699034000568 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 699034000569 inhibitor binding site; inhibition site 699034000570 active site 699034000571 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 699034000572 MFS/sugar transport protein; Region: MFS_2; pfam13347 699034000573 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 699034000574 Helix-turn-helix domains; Region: HTH; cl00088 699034000575 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 699034000576 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 699034000577 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 699034000578 tetramer interface [polypeptide binding]; other site 699034000579 TPP-binding site [chemical binding]; other site 699034000580 heterodimer interface [polypeptide binding]; other site 699034000581 phosphorylation loop region [posttranslational modification] 699034000582 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 699034000583 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 699034000584 alpha subunit interface [polypeptide binding]; other site 699034000585 TPP binding site [chemical binding]; other site 699034000586 heterodimer interface [polypeptide binding]; other site 699034000587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 699034000588 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 699034000589 e3 binding domain; Region: E3_binding; pfam02817 699034000590 e3 binding domain; Region: E3_binding; pfam02817 699034000591 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 699034000592 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 699034000593 E3 interaction surface; other site 699034000594 lipoyl attachment site [posttranslational modification]; other site 699034000595 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 699034000596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034000597 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 699034000598 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 699034000599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034000600 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 699034000601 Walker A motif; other site 699034000602 ATP binding site [chemical binding]; other site 699034000603 Walker B motif; other site 699034000604 arginine finger; other site 699034000605 PRD domain; Region: PRD; cl15445 699034000606 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 699034000607 active pocket/dimerization site; other site 699034000608 active site 699034000609 phosphorylation site [posttranslational modification] 699034000610 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034000611 active site 699034000612 phosphorylation site [posttranslational modification] 699034000613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034000614 active site 699034000615 phosphorylation site [posttranslational modification] 699034000616 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 699034000617 active site 699034000618 P-loop; other site 699034000619 phosphorylation site [posttranslational modification] 699034000620 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 699034000621 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 699034000622 intersubunit interface [polypeptide binding]; other site 699034000623 active site 699034000624 Zn2+ binding site [ion binding]; other site 699034000625 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 699034000626 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 699034000627 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 699034000628 substrate binding site; other site 699034000629 dimer interface; other site 699034000630 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 699034000631 homotrimer interaction site [polypeptide binding]; other site 699034000632 zinc binding site [ion binding]; other site 699034000633 CDP-binding sites; other site 699034000634 prolyl-tRNA synthetase; Provisional; Region: PRK09194 699034000635 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 699034000636 dimer interface [polypeptide binding]; other site 699034000637 motif 1; other site 699034000638 active site 699034000639 motif 2; other site 699034000640 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 699034000641 putative deacylase active site [active] 699034000642 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 699034000643 active site 699034000644 motif 3; other site 699034000645 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 699034000646 anticodon binding site; other site 699034000647 prolyl-tRNA synthetase; Provisional; Region: PRK08661 699034000648 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 699034000649 dimer interface [polypeptide binding]; other site 699034000650 motif 1; other site 699034000651 active site 699034000652 motif 2; other site 699034000653 motif 3; other site 699034000654 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 699034000655 anticodon binding site; other site 699034000656 zinc-binding site [ion binding]; other site 699034000657 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 699034000658 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 699034000659 active site 699034000660 HIGH motif; other site 699034000661 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 699034000662 active site 699034000663 KMSKS motif; other site 699034000664 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 699034000665 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 699034000666 active site 699034000667 HIGH motif; other site 699034000668 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 699034000669 KMSKS motif; other site 699034000670 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 699034000671 tRNA binding surface [nucleotide binding]; other site 699034000672 anticodon binding site; other site 699034000673 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 699034000674 active site 699034000675 metal binding site [ion binding]; metal-binding site 699034000676 dimerization interface [polypeptide binding]; other site 699034000677 Thymidylate synthase complementing protein; Region: Thy1; cl03630 699034000678 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 699034000679 dimerization interface [polypeptide binding]; other site 699034000680 active site 699034000681 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 699034000682 folate binding site [chemical binding]; other site 699034000683 NADP+ binding site [chemical binding]; other site 699034000684 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 699034000685 ThiC family; Region: ThiC; cl08031 699034000686 Thymidylate synthase complementing protein; Region: Thy1; cl03630 699034000687 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 699034000688 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 699034000689 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 699034000690 YacP-like NYN domain; Region: NYN_YacP; cl01491 699034000691 RNA polymerase factor sigma-70; Validated; Region: PRK08295 699034000692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034000693 elongation factor Tu; Reviewed; Region: PRK00049 699034000694 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 699034000695 G1 box; other site 699034000696 GEF interaction site [polypeptide binding]; other site 699034000697 GTP/Mg2+ binding site [chemical binding]; other site 699034000698 Switch I region; other site 699034000699 G2 box; other site 699034000700 G3 box; other site 699034000701 Switch II region; other site 699034000702 G4 box; other site 699034000703 G5 box; other site 699034000704 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 699034000705 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 699034000706 Antibiotic Binding Site [chemical binding]; other site 699034000707 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 699034000708 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 699034000709 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 699034000710 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 699034000711 putative homodimer interface [polypeptide binding]; other site 699034000712 KOW motif; Region: KOW; cl00354 699034000713 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 699034000714 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 699034000715 23S rRNA interface [nucleotide binding]; other site 699034000716 L7/L12 interface [polypeptide binding]; other site 699034000717 putative thiostrepton binding site; other site 699034000718 L25 interface [polypeptide binding]; other site 699034000719 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 699034000720 mRNA/rRNA interface [nucleotide binding]; other site 699034000721 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 699034000722 23S rRNA interface [nucleotide binding]; other site 699034000723 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 699034000724 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 699034000725 core dimer interface [polypeptide binding]; other site 699034000726 peripheral dimer interface [polypeptide binding]; other site 699034000727 L10 interface [polypeptide binding]; other site 699034000728 L11 interface [polypeptide binding]; other site 699034000729 putative EF-Tu interaction site [polypeptide binding]; other site 699034000730 putative EF-G interaction site [polypeptide binding]; other site 699034000731 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 699034000732 classical (c) SDRs; Region: SDR_c; cd05233 699034000733 NAD(P) binding site [chemical binding]; other site 699034000734 active site 699034000735 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 699034000736 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 699034000737 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 699034000738 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 699034000739 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 699034000740 RPB1 interaction site [polypeptide binding]; other site 699034000741 RPB10 interaction site [polypeptide binding]; other site 699034000742 RPB11 interaction site [polypeptide binding]; other site 699034000743 RPB3 interaction site [polypeptide binding]; other site 699034000744 RPB12 interaction site [polypeptide binding]; other site 699034000745 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 699034000746 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 699034000747 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 699034000748 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 699034000749 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 699034000750 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 699034000751 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 699034000752 G-loop; other site 699034000753 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 699034000754 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 699034000755 DNA binding site [nucleotide binding] 699034000756 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 699034000757 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 699034000758 S17 interaction site [polypeptide binding]; other site 699034000759 S8 interaction site; other site 699034000760 16S rRNA interaction site [nucleotide binding]; other site 699034000761 streptomycin interaction site [chemical binding]; other site 699034000762 23S rRNA interaction site [nucleotide binding]; other site 699034000763 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 699034000764 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 699034000765 elongation factor G; Reviewed; Region: PRK00007 699034000766 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 699034000767 G1 box; other site 699034000768 putative GEF interaction site [polypeptide binding]; other site 699034000769 GTP/Mg2+ binding site [chemical binding]; other site 699034000770 Switch I region; other site 699034000771 G2 box; other site 699034000772 G3 box; other site 699034000773 Switch II region; other site 699034000774 G4 box; other site 699034000775 G5 box; other site 699034000776 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 699034000777 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 699034000778 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 699034000779 elongation factor Tu; Reviewed; Region: PRK00049 699034000780 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 699034000781 G1 box; other site 699034000782 GEF interaction site [polypeptide binding]; other site 699034000783 GTP/Mg2+ binding site [chemical binding]; other site 699034000784 Switch I region; other site 699034000785 G2 box; other site 699034000786 G3 box; other site 699034000787 Switch II region; other site 699034000788 G4 box; other site 699034000789 G5 box; other site 699034000790 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 699034000791 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 699034000792 Antibiotic Binding Site [chemical binding]; other site 699034000793 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 699034000794 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 699034000795 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 699034000796 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 699034000797 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 699034000798 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 699034000799 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 699034000800 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 699034000801 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 699034000802 putative translocon binding site; other site 699034000803 protein-rRNA interface [nucleotide binding]; other site 699034000804 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 699034000805 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 699034000806 G-X-X-G motif; other site 699034000807 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 699034000808 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 699034000809 23S rRNA interface [nucleotide binding]; other site 699034000810 5S rRNA interface [nucleotide binding]; other site 699034000811 putative antibiotic binding site [chemical binding]; other site 699034000812 L25 interface [polypeptide binding]; other site 699034000813 L27 interface [polypeptide binding]; other site 699034000814 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 699034000815 23S rRNA interface [nucleotide binding]; other site 699034000816 putative translocon interaction site; other site 699034000817 signal recognition particle (SRP54) interaction site; other site 699034000818 L23 interface [polypeptide binding]; other site 699034000819 trigger factor interaction site; other site 699034000820 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 699034000821 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 699034000822 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 699034000823 KOW motif; Region: KOW; cl00354 699034000824 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 699034000825 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 699034000826 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 699034000827 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 699034000828 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 699034000829 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 699034000830 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 699034000831 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 699034000832 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 699034000833 5S rRNA interface [nucleotide binding]; other site 699034000834 L27 interface [polypeptide binding]; other site 699034000835 23S rRNA interface [nucleotide binding]; other site 699034000836 L5 interface [polypeptide binding]; other site 699034000837 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 699034000838 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 699034000839 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 699034000840 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 699034000841 23S rRNA binding site [nucleotide binding]; other site 699034000842 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 699034000843 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 699034000844 SecY translocase; Region: SecY; pfam00344 699034000845 adenylate kinase; Reviewed; Region: adk; PRK00279 699034000846 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 699034000847 AMP-binding site [chemical binding]; other site 699034000848 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 699034000849 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 699034000850 active site 699034000851 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 699034000852 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 699034000853 rRNA binding site [nucleotide binding]; other site 699034000854 predicted 30S ribosome binding site; other site 699034000855 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 699034000856 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 699034000857 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 699034000858 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 699034000859 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 699034000860 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 699034000861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 699034000862 RNA binding surface [nucleotide binding]; other site 699034000863 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 699034000864 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 699034000865 alphaNTD - beta interaction site [polypeptide binding]; other site 699034000866 alphaNTD homodimer interface [polypeptide binding]; other site 699034000867 alphaNTD - beta' interaction site [polypeptide binding]; other site 699034000868 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 699034000869 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 699034000870 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 699034000871 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 699034000872 Walker A/P-loop; other site 699034000873 ATP binding site [chemical binding]; other site 699034000874 Q-loop/lid; other site 699034000875 ABC transporter signature motif; other site 699034000876 Walker B; other site 699034000877 D-loop; other site 699034000878 H-loop/switch region; other site 699034000879 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 699034000880 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 699034000881 Walker A/P-loop; other site 699034000882 ATP binding site [chemical binding]; other site 699034000883 Q-loop/lid; other site 699034000884 ABC transporter signature motif; other site 699034000885 Walker B; other site 699034000886 D-loop; other site 699034000887 H-loop/switch region; other site 699034000888 Cobalt transport protein; Region: CbiQ; cl00463 699034000889 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 699034000890 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 699034000891 dimerization interface 3.5A [polypeptide binding]; other site 699034000892 active site 699034000893 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 699034000894 23S rRNA interface [nucleotide binding]; other site 699034000895 L3 interface [polypeptide binding]; other site 699034000896 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 699034000897 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034000898 active site 699034000899 metal binding site [ion binding]; metal-binding site 699034000900 potential RNA of insufficient length (23S ribosomal RNA) 699034000901 potential protein location (hypothetical protein CDBI1_00600 [Clostridium difficile BI1]) that overlaps RNA (tRNA-D) 699034000902 potential RNA of insufficient length (23S ribosomal RNA) 699034000903 aspartate aminotransferase; Provisional; Region: PRK05764 699034000904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034000905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034000906 homodimer interface [polypeptide binding]; other site 699034000907 catalytic residue [active] 699034000908 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 699034000909 ATP cone domain; Region: ATP-cone; pfam03477 699034000910 Class III ribonucleotide reductase; Region: RNR_III; cd01675 699034000911 effector binding site; other site 699034000912 active site 699034000913 Zn binding site [ion binding]; other site 699034000914 glycine loop; other site 699034000915 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 699034000916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034000917 FeS/SAM binding site; other site 699034000918 potential RNA of insufficient length (23S ribosomal RNA) 699034000919 potential RNA of insufficient length (23S ribosomal RNA) 699034000920 Uncharacterized conserved protein [Function unknown]; Region: COG1624 699034000921 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 699034000922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 699034000923 YbbR-like protein; Region: YbbR; pfam07949 699034000924 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 699034000925 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 699034000926 Acetokinase family; Region: Acetate_kinase; cl01029 699034000927 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 699034000928 4Fe-4S binding domain; Region: Fer4; cl02805 699034000929 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 699034000930 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 699034000931 dimer interface [polypeptide binding]; other site 699034000932 PYR/PP interface [polypeptide binding]; other site 699034000933 TPP binding site [chemical binding]; other site 699034000934 substrate binding site [chemical binding]; other site 699034000935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 699034000936 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 699034000937 TPP-binding site [chemical binding]; other site 699034000938 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 699034000939 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 699034000940 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 699034000941 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 699034000942 active site 699034000943 substrate binding site [chemical binding]; other site 699034000944 metal binding site [ion binding]; metal-binding site 699034000945 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 699034000946 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 699034000947 glutaminase active site [active] 699034000948 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 699034000949 dimer interface [polypeptide binding]; other site 699034000950 active site 699034000951 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 699034000952 dimer interface [polypeptide binding]; other site 699034000953 active site 699034000954 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 699034000955 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 699034000956 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 699034000957 active site residue [active] 699034000958 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 699034000959 active site residue [active] 699034000960 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 699034000961 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 699034000962 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 699034000963 hinge; other site 699034000964 active site 699034000965 stage II sporulation protein D; Region: spore_II_D; TIGR02870 699034000966 Stage II sporulation protein; Region: SpoIID; pfam08486 699034000967 Peptidase family M23; Region: Peptidase_M23; pfam01551 699034000968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034000969 rod shape-determining protein Mbl; Provisional; Region: PRK13928 699034000970 Cell division protein FtsA; Region: FtsA; cl11496 699034000971 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 699034000972 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 699034000973 S-adenosylmethionine synthetase; Validated; Region: PRK05250 699034000974 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 699034000975 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 699034000976 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 699034000977 Uncharacterized membrane protein [Function unknown]; Region: COG3949 699034000978 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 699034000979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034000980 Family description; Region: UvrD_C_2; cl15862 699034000981 comF family protein; Region: comF; TIGR00201 699034000982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034000983 active site 699034000984 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034000985 PRD domain; Region: PRD; cl15445 699034000986 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034000987 active site 699034000988 P-loop; other site 699034000989 phosphorylation site [posttranslational modification] 699034000990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034000991 active site 699034000992 phosphorylation site [posttranslational modification] 699034000993 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 699034000994 methionine cluster; other site 699034000995 active site 699034000996 phosphorylation site [posttranslational modification] 699034000997 metal binding site [ion binding]; metal-binding site 699034000998 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034000999 active site 699034001000 P-loop; other site 699034001001 phosphorylation site [posttranslational modification] 699034001002 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034001003 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 699034001004 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 699034001005 active site 699034001006 dimer interface [polypeptide binding]; other site 699034001007 catalytic nucleophile [active] 699034001008 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 699034001009 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 699034001010 metal binding site [ion binding]; metal-binding site 699034001011 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 699034001012 CutC family; Region: CutC; cl01218 699034001013 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 699034001014 30S subunit binding site; other site 699034001015 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 699034001016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001017 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 699034001018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001019 nucleotide binding region [chemical binding]; other site 699034001020 SEC-C motif; Region: SEC-C; pfam02810 699034001021 peptide chain release factor 2; Provisional; Region: PRK05589 699034001022 RF-1 domain; Region: RF-1; cl02875 699034001023 RF-1 domain; Region: RF-1; cl02875 699034001024 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 699034001025 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 699034001026 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 699034001027 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034001028 RNA binding site [nucleotide binding]; other site 699034001029 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 699034001030 Amidohydrolase; Region: Amidohydro_4; pfam13147 699034001031 active site 699034001032 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 699034001033 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 699034001034 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034001035 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034001036 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034001037 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034001038 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 699034001039 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 699034001040 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 699034001041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034001042 Coenzyme A binding pocket [chemical binding]; other site 699034001043 UGMP family protein; Validated; Region: PRK09604 699034001044 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 699034001045 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 699034001046 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 699034001047 dimer interface [polypeptide binding]; other site 699034001048 active site 699034001049 glycine loop; other site 699034001050 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 699034001051 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 699034001052 CAAX protease self-immunity; Region: Abi; cl00558 699034001053 CAAX protease self-immunity; Region: Abi; cl00558 699034001054 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 699034001055 active site 699034001056 metal binding site [ion binding]; metal-binding site 699034001057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 699034001058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001059 active site 699034001060 phosphorylation site [posttranslational modification] 699034001061 intermolecular recognition site; other site 699034001062 dimerization interface [polypeptide binding]; other site 699034001063 LytTr DNA-binding domain; Region: LytTR; cl04498 699034001064 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034001065 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 699034001066 Walker A/P-loop; other site 699034001067 ATP binding site [chemical binding]; other site 699034001068 Q-loop/lid; other site 699034001069 ABC transporter signature motif; other site 699034001070 Walker B; other site 699034001071 D-loop; other site 699034001072 H-loop/switch region; other site 699034001073 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 699034001074 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034001075 FeS/SAM binding site; other site 699034001076 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 699034001077 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 699034001078 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 699034001079 Spore germination protein; Region: Spore_permease; cl15802 699034001080 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034001081 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 699034001082 metal binding site [ion binding]; metal-binding site 699034001083 dimer interface [polypeptide binding]; other site 699034001084 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034001085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034001086 Walker A motif; other site 699034001087 ATP binding site [chemical binding]; other site 699034001088 Walker B motif; other site 699034001089 arginine finger; other site 699034001090 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 699034001091 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 699034001092 ligand binding site [chemical binding]; other site 699034001093 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 699034001094 MatE; Region: MatE; cl10513 699034001095 MatE; Region: MatE; cl10513 699034001096 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 699034001097 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034001098 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034001099 ABC transporter; Region: ABC_tran_2; pfam12848 699034001100 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034001101 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 699034001102 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 699034001103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034001104 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 699034001105 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 699034001106 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 699034001107 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 699034001108 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034001109 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 699034001110 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 699034001111 putative active site [active] 699034001112 putative metal binding site [ion binding]; other site 699034001113 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 699034001114 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034001115 ACS interaction site; other site 699034001116 CODH interaction site; other site 699034001117 metal cluster binding site [ion binding]; other site 699034001118 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 699034001119 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 699034001120 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 699034001121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034001122 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 699034001123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034001124 S-adenosylmethionine binding site [chemical binding]; other site 699034001125 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 699034001126 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 699034001127 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 699034001128 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 699034001129 NAD(P) binding site [chemical binding]; other site 699034001130 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034001131 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034001132 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 699034001133 Bacterial SH3 domain; Region: SH3_3; cl02551 699034001134 Bacterial SH3 domain; Region: SH3_3; cl02551 699034001135 NlpC/P60 family; Region: NLPC_P60; cl11438 699034001136 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 699034001137 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 699034001138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034001139 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 699034001140 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 699034001141 FAD binding pocket [chemical binding]; other site 699034001142 FAD binding motif [chemical binding]; other site 699034001143 phosphate binding motif [ion binding]; other site 699034001144 beta-alpha-beta structure motif; other site 699034001145 NAD binding pocket [chemical binding]; other site 699034001146 Iron coordination center [ion binding]; other site 699034001147 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 699034001148 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 699034001149 heterodimer interface [polypeptide binding]; other site 699034001150 active site 699034001151 FMN binding site [chemical binding]; other site 699034001152 homodimer interface [polypeptide binding]; other site 699034001153 substrate binding site [chemical binding]; other site 699034001154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034001155 active site 699034001156 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 699034001157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034001158 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 699034001159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034001160 Helix-turn-helix domains; Region: HTH; cl00088 699034001161 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 699034001162 putative dimerization interface [polypeptide binding]; other site 699034001163 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 699034001164 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 699034001165 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 699034001166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 699034001167 minor groove reading motif; other site 699034001168 helix-hairpin-helix signature motif; other site 699034001169 substrate binding pocket [chemical binding]; other site 699034001170 active site 699034001171 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 699034001172 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 699034001173 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 699034001174 putative active site [active] 699034001175 catalytic site [active] 699034001176 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 699034001177 putative active site [active] 699034001178 catalytic site [active] 699034001179 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 699034001180 oligomerisation interface [polypeptide binding]; other site 699034001181 mobile loop; other site 699034001182 roof hairpin; other site 699034001183 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 699034001184 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 699034001185 ring oligomerisation interface [polypeptide binding]; other site 699034001186 ATP/Mg binding site [chemical binding]; other site 699034001187 stacking interactions; other site 699034001188 hinge regions; other site 699034001189 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 699034001190 AIR carboxylase; Region: AIRC; cl00310 699034001191 Protein of unknown function DUF111; Region: DUF111; cl03398 699034001192 Protein of unknown function DUF111; Region: DUF111; cl03398 699034001193 GMP synthase; Reviewed; Region: guaA; PRK00074 699034001194 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 699034001195 AMP/PPi binding site [chemical binding]; other site 699034001196 candidate oxyanion hole; other site 699034001197 catalytic triad [active] 699034001198 potential glutamine specificity residues [chemical binding]; other site 699034001199 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 699034001200 ATP Binding subdomain [chemical binding]; other site 699034001201 Ligand Binding sites [chemical binding]; other site 699034001202 Dimerization subdomain; other site 699034001203 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034001204 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 699034001205 active site 699034001206 metal binding site [ion binding]; metal-binding site 699034001207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034001208 Helix-turn-helix domains; Region: HTH; cl00088 699034001209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034001210 dimerization interface [polypeptide binding]; other site 699034001211 Chromate transporter; Region: Chromate_transp; pfam02417 699034001212 Chromate transporter; Region: Chromate_transp; pfam02417 699034001213 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034001214 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034001215 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 699034001216 AAA domain; Region: AAA_21; pfam13304 699034001217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034001218 metal binding site [ion binding]; metal-binding site 699034001219 active site 699034001220 I-site; other site 699034001221 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034001222 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034001223 PRD domain; Region: PRD; cl15445 699034001224 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034001225 active site 699034001226 P-loop; other site 699034001227 phosphorylation site [posttranslational modification] 699034001228 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 699034001229 active site 699034001230 phosphorylation site [posttranslational modification] 699034001231 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034001232 active site 699034001233 phosphorylation site [posttranslational modification] 699034001234 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034001235 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034001236 active site 699034001237 P-loop; other site 699034001238 phosphorylation site [posttranslational modification] 699034001239 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 699034001240 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 699034001241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034001242 motif II; other site 699034001243 Coat F domain; Region: Coat_F; cl15836 699034001244 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 699034001245 putative FMN binding site [chemical binding]; other site 699034001246 AIR carboxylase; Region: AIRC; cl00310 699034001247 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 699034001248 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 699034001249 ATP binding site [chemical binding]; other site 699034001250 active site 699034001251 substrate binding site [chemical binding]; other site 699034001252 amidophosphoribosyltransferase; Region: purF; TIGR01134 699034001253 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 699034001254 active site 699034001255 tetramer interface [polypeptide binding]; other site 699034001256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034001257 active site 699034001258 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 699034001259 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 699034001260 dimerization interface [polypeptide binding]; other site 699034001261 putative ATP binding site [chemical binding]; other site 699034001262 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 699034001263 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 699034001264 active site 699034001265 substrate binding site [chemical binding]; other site 699034001266 cosubstrate binding site; other site 699034001267 catalytic site [active] 699034001268 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 699034001269 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 699034001270 purine monophosphate binding site [chemical binding]; other site 699034001271 dimer interface [polypeptide binding]; other site 699034001272 putative catalytic residues [active] 699034001273 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 699034001274 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 699034001275 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 699034001276 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 699034001277 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034001278 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 699034001279 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 699034001280 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 699034001281 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 699034001282 dimerization interface [polypeptide binding]; other site 699034001283 ATP binding site [chemical binding]; other site 699034001284 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 699034001285 dimerization interface [polypeptide binding]; other site 699034001286 ATP binding site [chemical binding]; other site 699034001287 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 699034001288 putative active site [active] 699034001289 catalytic triad [active] 699034001290 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 699034001291 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 699034001292 NADP binding site [chemical binding]; other site 699034001293 active site 699034001294 putative substrate binding site [chemical binding]; other site 699034001295 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 699034001296 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 699034001297 substrate binding site; other site 699034001298 tetramer interface; other site 699034001299 Cupin domain; Region: Cupin_2; cl09118 699034001300 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 699034001301 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 699034001302 NAD binding site [chemical binding]; other site 699034001303 substrate binding site [chemical binding]; other site 699034001304 homodimer interface [polypeptide binding]; other site 699034001305 active site 699034001306 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 699034001307 N-acetyl-D-glucosamine binding site [chemical binding]; other site 699034001308 catalytic residue [active] 699034001309 Protein of unknown function (DUF327); Region: DUF327; cl00753 699034001310 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 699034001311 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 699034001312 FlgN protein; Region: FlgN; cl09176 699034001313 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 699034001314 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 699034001315 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 699034001316 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 699034001317 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 699034001318 FliW protein; Region: FliW; cl00740 699034001319 Global regulator protein family; Region: CsrA; cl00670 699034001320 Flagellar protein FliS; Region: FliS; cl00654 699034001321 Flagellar protein FliS; Region: FliS; cl00654 699034001322 flagellar capping protein; Validated; Region: fliD; PRK07737 699034001323 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 699034001324 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 699034001325 Flagellar protein FliT; Region: FliT; cl05125 699034001326 flagellin; Provisional; Region: PRK12804 699034001327 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 699034001328 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 699034001329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 699034001330 active site 699034001331 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 699034001332 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 699034001333 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 699034001334 Probable Catalytic site; other site 699034001335 metal-binding site 699034001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034001337 S-adenosylmethionine binding site [chemical binding]; other site 699034001338 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 699034001339 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034001340 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 699034001341 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034001342 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 699034001343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034001344 Cupin domain; Region: Cupin_2; cl09118 699034001345 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 699034001346 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 699034001347 inhibitor-cofactor binding pocket; inhibition site 699034001348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034001349 catalytic residue [active] 699034001350 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12623 699034001351 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 699034001352 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 699034001353 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 699034001354 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 699034001355 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 699034001356 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 699034001357 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 699034001358 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 699034001359 FliG C-terminal domain; Region: FliG_C; pfam01706 699034001360 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 699034001361 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 699034001362 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 699034001363 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 699034001364 Walker A motif/ATP binding site; other site 699034001365 Walker B motif; other site 699034001366 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 699034001367 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 699034001368 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 699034001369 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 699034001370 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 699034001371 Flagellar protein (FlbD); Region: FlbD; cl00683 699034001372 flagellar motor protein MotP; Reviewed; Region: PRK06926 699034001373 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 699034001374 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 699034001375 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 699034001376 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 699034001377 ligand binding site [chemical binding]; other site 699034001378 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 699034001379 FliP family; Region: FliP; cl00593 699034001380 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 699034001381 bifunctional flagellar biosynthesis protein FliR/FlhB; Provisional; Region: PRK12772 699034001382 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 699034001383 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 699034001384 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 699034001385 FHIPEP family; Region: FHIPEP; pfam00771 699034001386 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 699034001387 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 699034001388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001389 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 699034001390 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 699034001391 P-loop; other site 699034001392 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 699034001393 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 699034001394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034001395 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 699034001396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034001397 DNA binding residues [nucleotide binding] 699034001398 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 699034001399 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 699034001400 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12817 699034001401 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 699034001402 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 699034001403 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 699034001404 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 699034001405 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 699034001406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 699034001407 heat shock protein 90; Provisional; Region: PRK05218 699034001408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034001409 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 699034001410 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 699034001411 putative active site [active] 699034001412 metal binding site [ion binding]; metal-binding site 699034001413 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 699034001414 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 699034001415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034001416 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034001417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034001418 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034001419 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 699034001420 Helix-turn-helix domains; Region: HTH; cl00088 699034001421 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 699034001422 putative hydrolase; Validated; Region: PRK09248 699034001423 RNase P subunit p30; Region: RNase_P_p30; cl03389 699034001424 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 699034001425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034001426 Walker A motif; other site 699034001427 ATP binding site [chemical binding]; other site 699034001428 Walker B motif; other site 699034001429 arginine finger; other site 699034001430 PRD domain; Region: PRD; cl15445 699034001431 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 699034001432 active pocket/dimerization site; other site 699034001433 active site 699034001434 phosphorylation site [posttranslational modification] 699034001435 PRD domain; Region: PRD; cl15445 699034001436 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 699034001437 active pocket/dimerization site; other site 699034001438 active site 699034001439 phosphorylation site [posttranslational modification] 699034001440 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 699034001441 active site 699034001442 phosphorylation site [posttranslational modification] 699034001443 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 699034001444 active pocket/dimerization site; other site 699034001445 active site 699034001446 phosphorylation site [posttranslational modification] 699034001447 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 699034001448 active site 699034001449 phosphorylation site [posttranslational modification] 699034001450 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 699034001451 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 699034001452 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 699034001453 dipeptidase PepV; Reviewed; Region: PRK07318 699034001454 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 699034001455 active site 699034001456 metal binding site [ion binding]; metal-binding site 699034001457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034001458 non-specific DNA binding site [nucleotide binding]; other site 699034001459 salt bridge; other site 699034001460 sequence-specific DNA binding site [nucleotide binding]; other site 699034001461 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 699034001462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034001463 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001464 Walker A/P-loop; other site 699034001465 ATP binding site [chemical binding]; other site 699034001466 Q-loop/lid; other site 699034001467 ABC transporter signature motif; other site 699034001468 Walker B; other site 699034001469 D-loop; other site 699034001470 H-loop/switch region; other site 699034001471 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034001472 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 699034001473 biotin synthase; Region: bioB; TIGR00433 699034001474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034001475 FeS/SAM binding site; other site 699034001476 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 699034001477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 699034001478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 699034001479 DNA binding site [nucleotide binding] 699034001480 domain linker motif; other site 699034001481 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 699034001482 dimerization interface [polypeptide binding]; other site 699034001483 ligand binding site [chemical binding]; other site 699034001484 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 699034001485 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 699034001486 substrate binding site [chemical binding]; other site 699034001487 dimer interface [polypeptide binding]; other site 699034001488 ATP binding site [chemical binding]; other site 699034001489 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 699034001490 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 699034001491 ligand binding site [chemical binding]; other site 699034001492 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 699034001493 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 699034001494 Walker A/P-loop; other site 699034001495 ATP binding site [chemical binding]; other site 699034001496 Q-loop/lid; other site 699034001497 ABC transporter signature motif; other site 699034001498 Walker B; other site 699034001499 D-loop; other site 699034001500 H-loop/switch region; other site 699034001501 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 699034001502 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 699034001503 TM-ABC transporter signature motif; other site 699034001504 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 699034001505 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 699034001506 metal binding site [ion binding]; metal-binding site 699034001507 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 699034001508 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 699034001509 putative metal binding site [ion binding]; other site 699034001510 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034001511 FMN binding site [chemical binding]; other site 699034001512 dimer interface [polypeptide binding]; other site 699034001513 Helix-turn-helix domains; Region: HTH; cl00088 699034001514 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 699034001515 potential frameshift: common BLAST hit: gi|170754594|ref|YP_001780490.1| acetyltransferase 699034001516 Tetratricopeptide repeat; Region: TPR_16; pfam13432 699034001517 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 699034001518 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034001519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034001520 dimerization interface [polypeptide binding]; other site 699034001521 putative DNA binding site [nucleotide binding]; other site 699034001522 putative Zn2+ binding site [ion binding]; other site 699034001523 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 699034001524 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 699034001525 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 699034001526 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034001527 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034001528 potential RNA of insufficient length (23S ribosomal RNA) 699034001529 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 699034001530 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034001531 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034001532 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 699034001533 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034001534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001535 Walker A/P-loop; other site 699034001536 ATP binding site [chemical binding]; other site 699034001537 Q-loop/lid; other site 699034001538 ABC transporter signature motif; other site 699034001539 Walker B; other site 699034001540 D-loop; other site 699034001541 H-loop/switch region; other site 699034001542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034001543 dimer interface [polypeptide binding]; other site 699034001544 phosphorylation site [posttranslational modification] 699034001545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001546 ATP binding site [chemical binding]; other site 699034001547 Mg2+ binding site [ion binding]; other site 699034001548 G-X-G motif; other site 699034001549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034001550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001551 active site 699034001552 phosphorylation site [posttranslational modification] 699034001553 intermolecular recognition site; other site 699034001554 dimerization interface [polypeptide binding]; other site 699034001555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034001556 DNA binding site [nucleotide binding] 699034001557 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 699034001558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001559 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 699034001560 metal ion-dependent adhesion site (MIDAS); other site 699034001561 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 699034001562 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 699034001563 Cobalt transport protein component CbiN; Region: CbiN; cl00842 699034001564 Cobalt transport protein; Region: CbiQ; cl00463 699034001565 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 699034001566 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 699034001567 Walker A/P-loop; other site 699034001568 ATP binding site [chemical binding]; other site 699034001569 Q-loop/lid; other site 699034001570 ABC transporter signature motif; other site 699034001571 Walker B; other site 699034001572 D-loop; other site 699034001573 H-loop/switch region; other site 699034001574 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 699034001575 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001576 Family description; Region: UvrD_C_2; cl15862 699034001577 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 699034001578 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 699034001579 active site 699034001580 metal binding site [ion binding]; metal-binding site 699034001581 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 699034001582 active site 699034001583 nucleophile elbow; other site 699034001584 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 699034001585 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 699034001586 active site 699034001587 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 699034001588 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 699034001589 DRTGG domain; Region: DRTGG; cl12147 699034001590 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 699034001591 DHHA2 domain; Region: DHHA2; pfam02833 699034001592 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 699034001593 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 699034001594 putative catalytic cysteine [active] 699034001595 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 699034001596 putative active site [active] 699034001597 metal binding site [ion binding]; metal-binding site 699034001598 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034001599 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034001600 Walker A/P-loop; other site 699034001601 ATP binding site [chemical binding]; other site 699034001602 Q-loop/lid; other site 699034001603 ABC transporter signature motif; other site 699034001604 Walker B; other site 699034001605 D-loop; other site 699034001606 H-loop/switch region; other site 699034001607 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034001608 FtsX-like permease family; Region: FtsX; cl15850 699034001609 FtsX-like permease family; Region: FtsX; cl15850 699034001610 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 699034001611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001612 ATP binding site [chemical binding]; other site 699034001613 Mg2+ binding site [ion binding]; other site 699034001614 G-X-G motif; other site 699034001615 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 699034001616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001617 active site 699034001618 phosphorylation site [posttranslational modification] 699034001619 intermolecular recognition site; other site 699034001620 dimerization interface [polypeptide binding]; other site 699034001621 LytTr DNA-binding domain; Region: LytTR; cl04498 699034001622 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 699034001623 Flagellin N-methylase; Region: FliB; cl00497 699034001624 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 699034001625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034001626 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 699034001627 synthetase active site [active] 699034001628 NTP binding site [chemical binding]; other site 699034001629 metal binding site [ion binding]; metal-binding site 699034001630 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034001631 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 699034001632 active site 699034001633 metal binding site [ion binding]; metal-binding site 699034001634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034001635 S-adenosylmethionine binding site [chemical binding]; other site 699034001636 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034001637 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 699034001638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034001639 non-specific DNA binding site [nucleotide binding]; other site 699034001640 salt bridge; other site 699034001641 sequence-specific DNA binding site [nucleotide binding]; other site 699034001642 Cupin domain; Region: Cupin_2; cl09118 699034001643 D-aminoacyl-tRNA deacylase; Region: tRNA_deacylase; cl00716 699034001644 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 699034001645 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034001646 active site turn [active] 699034001647 phosphorylation site [posttranslational modification] 699034001648 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034001649 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034001650 HPr interaction site; other site 699034001651 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034001652 active site 699034001653 phosphorylation site [posttranslational modification] 699034001654 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034001655 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034001656 PRD domain; Region: PRD; cl15445 699034001657 PRD domain; Region: PRD; cl15445 699034001658 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 699034001659 active site 699034001660 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 699034001661 Ligand Binding Site [chemical binding]; other site 699034001662 Molecular Tunnel; other site 699034001663 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 699034001664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034001665 FeS/SAM binding site; other site 699034001666 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 699034001667 D-lactate dehydrogenase; Validated; Region: PRK08605 699034001668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034001669 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 699034001670 CoA-transferase family III; Region: CoA_transf_3; pfam02515 699034001671 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034001672 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 699034001673 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 699034001674 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 699034001675 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 699034001676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 699034001677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 699034001678 active site 699034001679 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 699034001680 Ligand binding site [chemical binding]; other site 699034001681 Electron transfer flavoprotein domain; Region: ETF; pfam01012 699034001682 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 699034001683 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 699034001684 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 699034001685 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034001686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034001687 Walker A motif; other site 699034001688 ATP binding site [chemical binding]; other site 699034001689 Walker B motif; other site 699034001690 arginine finger; other site 699034001691 Helix-turn-helix domains; Region: HTH; cl00088 699034001692 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 699034001693 hypothetical protein; Provisional; Region: PRK08185 699034001694 intersubunit interface [polypeptide binding]; other site 699034001695 active site 699034001696 zinc binding site [ion binding]; other site 699034001697 Na+ binding site [ion binding]; other site 699034001698 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 699034001699 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 699034001700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034001701 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034001702 Probable transposase; Region: OrfB_IS605; pfam01385 699034001703 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034001704 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 699034001705 pseudouridine synthase; Region: TIGR00093 699034001706 active site 699034001707 uracil binding [chemical binding]; other site 699034001708 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 699034001709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034001710 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034001711 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 699034001712 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034001713 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034001714 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034001715 putative transposase OrfB; Reviewed; Region: PHA02517 699034001716 HTH-like domain; Region: HTH_21; pfam13276 699034001717 Integrase core domain; Region: rve; cl01316 699034001718 Integrase core domain; Region: rve_3; cl15866 699034001719 Helix-turn-helix domains; Region: HTH; cl00088 699034001720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 699034001721 Helix-turn-helix domains; Region: HTH; cl00088 699034001722 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034001723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034001724 Walker A motif; other site 699034001725 ATP binding site [chemical binding]; other site 699034001726 Walker B motif; other site 699034001727 arginine finger; other site 699034001728 Helix-turn-helix domains; Region: HTH; cl00088 699034001729 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 699034001730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034001731 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 699034001732 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 699034001733 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034001734 catalytic residue [active] 699034001735 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 699034001736 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 699034001737 B12 binding site [chemical binding]; other site 699034001738 cobalt ligand [ion binding]; other site 699034001739 MutL protein; Region: MutL; pfam13941 699034001740 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 699034001741 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 699034001742 dimer interface [polypeptide binding]; other site 699034001743 active site 699034001744 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034001745 substrate binding site [chemical binding]; other site 699034001746 catalytic residue [active] 699034001747 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 699034001748 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034001749 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 699034001750 active site 699034001751 metal binding site [ion binding]; metal-binding site 699034001752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034001753 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034001754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034001755 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 699034001756 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001757 Family description; Region: UvrD_C_2; cl15862 699034001758 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034001759 AAA domain; Region: AAA_21; pfam13304 699034001760 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034001761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034001762 AAA domain; Region: AAA_21; pfam13304 699034001763 Walker A/P-loop; other site 699034001764 ATP binding site [chemical binding]; other site 699034001765 Q-loop/lid; other site 699034001766 ABC transporter signature motif; other site 699034001767 Walker B; other site 699034001768 D-loop; other site 699034001769 H-loop/switch region; other site 699034001770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034001771 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034001772 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034001773 Walker A/P-loop; other site 699034001774 ATP binding site [chemical binding]; other site 699034001775 Q-loop/lid; other site 699034001776 ABC transporter signature motif; other site 699034001777 Walker B; other site 699034001778 D-loop; other site 699034001779 H-loop/switch region; other site 699034001780 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 699034001781 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034001782 FtsX-like permease family; Region: FtsX; cl15850 699034001783 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 699034001784 FtsX-like permease family; Region: FtsX; cl15850 699034001785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034001786 dimer interface [polypeptide binding]; other site 699034001787 phosphorylation site [posttranslational modification] 699034001788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001789 ATP binding site [chemical binding]; other site 699034001790 Mg2+ binding site [ion binding]; other site 699034001791 G-X-G motif; other site 699034001792 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034001793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001794 active site 699034001795 phosphorylation site [posttranslational modification] 699034001796 intermolecular recognition site; other site 699034001797 dimerization interface [polypeptide binding]; other site 699034001798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034001799 DNA binding site [nucleotide binding] 699034001800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034001801 Helix-turn-helix domains; Region: HTH; cl00088 699034001802 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 699034001803 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034001804 Probable transposase; Region: OrfB_IS605; pfam01385 699034001805 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034001806 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034001807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034001808 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034001809 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034001810 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034001811 putative active site [active] 699034001812 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034001813 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034001814 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034001815 putative active site [active] 699034001816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034001817 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 699034001818 active site 699034001819 motif I; other site 699034001820 motif II; other site 699034001821 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034001822 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 699034001823 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 699034001824 Ca binding site [ion binding]; other site 699034001825 active site 699034001826 catalytic site [active] 699034001827 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 699034001828 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 699034001829 active site turn [active] 699034001830 phosphorylation site [posttranslational modification] 699034001831 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034001832 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034001833 HPr interaction site; other site 699034001834 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034001835 active site 699034001836 phosphorylation site [posttranslational modification] 699034001837 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034001838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034001839 Helix-turn-helix domains; Region: HTH; cl00088 699034001840 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034001841 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034001842 Helix-turn-helix domains; Region: HTH; cl00088 699034001843 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034001844 4Fe-4S binding domain; Region: Fer4; cl02805 699034001845 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 699034001846 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 699034001847 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034001848 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 699034001849 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034001850 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 699034001851 Helix-turn-helix domains; Region: HTH; cl00088 699034001852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034001853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034001854 dimer interface [polypeptide binding]; other site 699034001855 phosphorylation site [posttranslational modification] 699034001856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001857 ATP binding site [chemical binding]; other site 699034001858 Mg2+ binding site [ion binding]; other site 699034001859 G-X-G motif; other site 699034001860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034001861 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 699034001862 FtsX-like permease family; Region: FtsX; cl15850 699034001863 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034001864 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034001865 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034001866 Walker A/P-loop; other site 699034001867 ATP binding site [chemical binding]; other site 699034001868 Q-loop/lid; other site 699034001869 ABC transporter signature motif; other site 699034001870 Walker B; other site 699034001871 D-loop; other site 699034001872 H-loop/switch region; other site 699034001873 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 699034001874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034001875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 699034001876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001877 ATP binding site [chemical binding]; other site 699034001878 Mg2+ binding site [ion binding]; other site 699034001879 G-X-G motif; other site 699034001880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034001881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001882 active site 699034001883 phosphorylation site [posttranslational modification] 699034001884 intermolecular recognition site; other site 699034001885 dimerization interface [polypeptide binding]; other site 699034001886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034001887 DNA binding site [nucleotide binding] 699034001888 Predicted amidohydrolase [General function prediction only]; Region: COG0388 699034001889 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 699034001890 putative active site [active] 699034001891 catalytic triad [active] 699034001892 dimer interface [polypeptide binding]; other site 699034001893 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 699034001894 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 699034001895 ATP binding site [chemical binding]; other site 699034001896 active site 699034001897 substrate binding site [chemical binding]; other site 699034001898 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 699034001899 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 699034001900 putative NAD(P) binding site [chemical binding]; other site 699034001901 catalytic Zn binding site [ion binding]; other site 699034001902 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 699034001903 active pocket/dimerization site; other site 699034001904 active site 699034001905 phosphorylation site [posttranslational modification] 699034001906 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 699034001907 active site 699034001908 phosphorylation site [posttranslational modification] 699034001909 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 699034001910 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 699034001911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001913 active site 699034001914 phosphorylation site [posttranslational modification] 699034001915 intermolecular recognition site; other site 699034001916 dimerization interface [polypeptide binding]; other site 699034001917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034001918 DNA binding site [nucleotide binding] 699034001919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034001920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034001921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034001922 dimer interface [polypeptide binding]; other site 699034001923 phosphorylation site [posttranslational modification] 699034001924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001925 ATP binding site [chemical binding]; other site 699034001926 Mg2+ binding site [ion binding]; other site 699034001927 G-X-G motif; other site 699034001928 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034001929 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034001930 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034001931 flagellin; Validated; Region: PRK08026 699034001932 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 699034001933 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034001934 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 699034001935 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 699034001936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034001937 Walker A motif; other site 699034001938 ATP binding site [chemical binding]; other site 699034001939 Walker B motif; other site 699034001940 arginine finger; other site 699034001941 Transcriptional antiterminator [Transcription]; Region: COG3933 699034001942 PRD domain; Region: PRD; cl15445 699034001943 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 699034001944 active pocket/dimerization site; other site 699034001945 active site 699034001946 phosphorylation site [posttranslational modification] 699034001947 PRD domain; Region: PRD; cl15445 699034001948 Uncharacterized conserved protein [Function unknown]; Region: COG2966 699034001949 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 699034001950 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 699034001951 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 699034001952 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 699034001953 GAF domain; Region: GAF; cl15785 699034001954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034001955 dimer interface [polypeptide binding]; other site 699034001956 phosphorylation site [posttranslational modification] 699034001957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034001958 ATP binding site [chemical binding]; other site 699034001959 Mg2+ binding site [ion binding]; other site 699034001960 G-X-G motif; other site 699034001961 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034001962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001963 active site 699034001964 phosphorylation site [posttranslational modification] 699034001965 intermolecular recognition site; other site 699034001966 dimerization interface [polypeptide binding]; other site 699034001967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034001968 DNA binding site [nucleotide binding] 699034001969 GAF domain; Region: GAF_2; pfam13185 699034001970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034001971 metal binding site [ion binding]; metal-binding site 699034001972 active site 699034001973 I-site; other site 699034001974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034001975 metal binding site [ion binding]; metal-binding site 699034001976 active site 699034001977 I-site; other site 699034001978 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034001979 Helix-turn-helix domains; Region: HTH; cl00088 699034001980 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 699034001981 peptidase T-like protein; Region: PepT-like; TIGR01883 699034001982 metal binding site [ion binding]; metal-binding site 699034001983 putative dimer interface [polypeptide binding]; other site 699034001984 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 699034001985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034001986 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 699034001987 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034001988 metal binding site [ion binding]; metal-binding site 699034001989 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 699034001990 Predicted transcriptional regulator [Transcription]; Region: COG2378 699034001991 Helix-turn-helix domains; Region: HTH; cl00088 699034001992 WYL domain; Region: WYL; cl14852 699034001993 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034001994 Response regulator receiver domain; Region: Response_reg; pfam00072 699034001995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034001996 active site 699034001997 phosphorylation site [posttranslational modification] 699034001998 intermolecular recognition site; other site 699034001999 dimerization interface [polypeptide binding]; other site 699034002000 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 699034002001 CheD chemotactic sensory transduction; Region: CheD; cl00810 699034002002 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 699034002003 Response regulator receiver domain; Region: Response_reg; pfam00072 699034002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034002005 active site 699034002006 phosphorylation site [posttranslational modification] 699034002007 intermolecular recognition site; other site 699034002008 dimerization interface [polypeptide binding]; other site 699034002009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034002010 metal binding site [ion binding]; metal-binding site 699034002011 active site 699034002012 I-site; other site 699034002013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 699034002014 dimerization interface [polypeptide binding]; other site 699034002015 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 699034002016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 699034002017 dimer interface [polypeptide binding]; other site 699034002018 putative CheW interface [polypeptide binding]; other site 699034002019 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 699034002020 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 699034002021 putative binding surface; other site 699034002022 active site 699034002023 P2 response regulator binding domain; Region: P2; pfam07194 699034002024 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 699034002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034002026 ATP binding site [chemical binding]; other site 699034002027 Mg2+ binding site [ion binding]; other site 699034002028 G-X-G motif; other site 699034002029 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 699034002030 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 699034002031 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 699034002032 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 699034002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034002034 CheB methylesterase; Region: CheB_methylest; pfam01339 699034002035 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 699034002036 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 699034002037 ornithine cyclodeaminase; Validated; Region: PRK08618 699034002038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034002039 Protein of unknown function (DUF975); Region: DUF975; cl10504 699034002040 Helix-turn-helix domains; Region: HTH; cl00088 699034002041 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034002042 Formin Homology 2 Domain; Region: FH2; pfam02181 699034002043 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 699034002044 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 699034002045 Protease prsW family; Region: PrsW-protease; cl15823 699034002046 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 699034002047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034002048 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 699034002049 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 699034002050 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 699034002051 Catalytic site [active] 699034002052 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 699034002053 Catalytic site [active] 699034002054 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 699034002055 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 699034002056 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 699034002057 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 699034002058 active site 699034002059 Glutaminase; Region: Glutaminase; cl00907 699034002060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034002061 dimerization interface [polypeptide binding]; other site 699034002062 putative DNA binding site [nucleotide binding]; other site 699034002063 putative Zn2+ binding site [ion binding]; other site 699034002064 endonuclease IV; Provisional; Region: PRK01060 699034002065 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 699034002066 AP (apurinic/apyrimidinic) site pocket; other site 699034002067 DNA interaction; other site 699034002068 Metal-binding active site; metal-binding site 699034002069 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 699034002070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 699034002071 active site 699034002072 catalytic tetrad [active] 699034002073 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034002074 Endodeoxyribonuclease RusA; Region: RusA; cl01885 699034002075 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 699034002076 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 699034002077 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034002078 AAA domain; Region: AAA_32; pfam13654 699034002079 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 699034002080 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 699034002081 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 699034002082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 699034002083 minor groove reading motif; other site 699034002084 helix-hairpin-helix signature motif; other site 699034002085 substrate binding pocket [chemical binding]; other site 699034002086 active site 699034002087 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 699034002088 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 699034002089 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 699034002090 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 699034002091 ligand binding site [chemical binding]; other site 699034002092 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 699034002093 ligand binding site [chemical binding]; other site 699034002094 YtxC-like family; Region: YtxC; cl08500 699034002095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 699034002096 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023 699034002097 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 699034002098 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 699034002099 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 699034002100 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 699034002101 active site 699034002102 dimer interface [polypeptide binding]; other site 699034002103 motif 1; other site 699034002104 motif 2; other site 699034002105 motif 3; other site 699034002106 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 699034002107 anticodon binding site; other site 699034002108 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034002109 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 699034002110 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 699034002111 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 699034002112 Helix-turn-helix domains; Region: HTH; cl00088 699034002113 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 699034002114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034002115 ATP binding site [chemical binding]; other site 699034002116 Mg2+ binding site [ion binding]; other site 699034002117 G-X-G motif; other site 699034002118 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034002119 H+ Antiporter protein; Region: 2A0121; TIGR00900 699034002120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034002121 Helix-turn-helix domains; Region: HTH; cl00088 699034002122 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 699034002123 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 699034002124 tetrameric interface [polypeptide binding]; other site 699034002125 activator binding site; other site 699034002126 NADP binding site [chemical binding]; other site 699034002127 substrate binding site [chemical binding]; other site 699034002128 catalytic residues [active] 699034002129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034002130 Helix-turn-helix domains; Region: HTH; cl00088 699034002131 phosphoenolpyruvate synthase; Validated; Region: PRK06241 699034002132 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 699034002133 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 699034002134 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034002135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002136 Walker A/P-loop; other site 699034002137 ATP binding site [chemical binding]; other site 699034002138 Q-loop/lid; other site 699034002139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034002140 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034002141 Probable transposase; Region: OrfB_IS605; pfam01385 699034002142 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034002143 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002144 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 699034002145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034002146 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034002147 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 699034002148 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 699034002149 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 699034002150 Active Sites [active] 699034002151 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 699034002152 ParB-like nuclease domain; Region: ParBc; cl02129 699034002153 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 699034002154 CotJB protein; Region: CotJB; pfam12652 699034002155 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 699034002156 dimanganese center [ion binding]; other site 699034002157 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 699034002158 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 699034002159 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 699034002160 DNA binding site [nucleotide binding] 699034002161 active site 699034002162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034002163 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 699034002164 IncA protein; Region: IncA; pfam04156 699034002165 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 699034002166 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 699034002167 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 699034002168 Cl- selectivity filter; other site 699034002169 Cl- binding residues [ion binding]; other site 699034002170 pore gating glutamate residue; other site 699034002171 H+/Cl- coupling transport residue; other site 699034002172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034002173 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034002174 Probable transposase; Region: OrfB_IS605; pfam01385 699034002175 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034002176 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 699034002177 Cl- binding residues [ion binding]; other site 699034002178 dimer interface [polypeptide binding]; other site 699034002179 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 699034002180 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034002181 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 699034002182 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 699034002183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034002184 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 699034002185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034002186 active site 699034002187 phosphorylation site [posttranslational modification] 699034002188 intermolecular recognition site; other site 699034002189 dimerization interface [polypeptide binding]; other site 699034002190 LytTr DNA-binding domain; Region: LytTR; cl04498 699034002191 FtsX-like permease family; Region: FtsX; cl15850 699034002192 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034002193 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034002194 Walker A/P-loop; other site 699034002195 ATP binding site [chemical binding]; other site 699034002196 Q-loop/lid; other site 699034002197 ABC transporter signature motif; other site 699034002198 Walker B; other site 699034002199 D-loop; other site 699034002200 H-loop/switch region; other site 699034002201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034002202 Helix-turn-helix domains; Region: HTH; cl00088 699034002203 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 699034002204 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034002205 DNA binding residues [nucleotide binding] 699034002206 drug binding residues [chemical binding]; other site 699034002207 dimer interface [polypeptide binding]; other site 699034002208 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034002209 LytTr DNA-binding domain; Region: LytTR; cl04498 699034002210 YvrJ protein family; Region: YvrJ; pfam12841 699034002211 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 699034002212 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 699034002213 Mor transcription activator family; Region: Mor; cl02360 699034002214 replicative DNA helicase; Region: DnaB; TIGR00665 699034002215 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 699034002216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002217 Walker A motif; other site 699034002218 ATP binding site [chemical binding]; other site 699034002219 Walker B motif; other site 699034002220 Mor transcription activator family; Region: Mor; cl02360 699034002221 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034002222 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 699034002223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034002224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002225 Walker A/P-loop; other site 699034002226 ATP binding site [chemical binding]; other site 699034002227 Q-loop/lid; other site 699034002228 ABC transporter signature motif; other site 699034002229 Walker B; other site 699034002230 D-loop; other site 699034002231 H-loop/switch region; other site 699034002232 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 699034002233 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 699034002234 ligand binding site [chemical binding]; other site 699034002235 flexible hinge region; other site 699034002236 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 699034002237 putative switch regulator; other site 699034002238 non-specific DNA interactions [nucleotide binding]; other site 699034002239 DNA binding site [nucleotide binding] 699034002240 sequence specific DNA binding site [nucleotide binding]; other site 699034002241 putative cAMP binding site [chemical binding]; other site 699034002242 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 699034002243 MatE; Region: MatE; cl10513 699034002244 MatE; Region: MatE; cl10513 699034002245 Helix-turn-helix domains; Region: HTH; cl00088 699034002246 A new structural DNA glycosylase; Region: AlkD_like; cl11434 699034002247 active site 699034002248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034002249 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034002250 Radical SAM superfamily; Region: Radical_SAM; pfam04055 699034002251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034002252 FeS/SAM binding site; other site 699034002253 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034002254 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 699034002255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034002256 sequence-specific DNA binding site [nucleotide binding]; other site 699034002257 salt bridge; other site 699034002258 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034002259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034002260 active site 699034002261 phosphorylation site [posttranslational modification] 699034002262 intermolecular recognition site; other site 699034002263 dimerization interface [polypeptide binding]; other site 699034002264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034002265 DNA binding site [nucleotide binding] 699034002266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034002267 dimer interface [polypeptide binding]; other site 699034002268 phosphorylation site [posttranslational modification] 699034002269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034002270 ATP binding site [chemical binding]; other site 699034002271 Mg2+ binding site [ion binding]; other site 699034002272 G-X-G motif; other site 699034002273 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034002274 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 699034002275 Walker A/P-loop; other site 699034002276 ATP binding site [chemical binding]; other site 699034002277 Q-loop/lid; other site 699034002278 ABC transporter signature motif; other site 699034002279 Walker B; other site 699034002280 D-loop; other site 699034002281 H-loop/switch region; other site 699034002282 Fic family protein [Function unknown]; Region: COG3177 699034002283 Fic/DOC family; Region: Fic; cl00960 699034002284 Transcriptional regulators [Transcription]; Region: FadR; COG2186 699034002285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034002286 DNA-binding site [nucleotide binding]; DNA binding site 699034002287 FCD domain; Region: FCD; cl11656 699034002288 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 699034002289 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034002290 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 699034002291 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034002292 Predicted transcriptional regulators [Transcription]; Region: COG1725 699034002293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034002294 DNA-binding site [nucleotide binding]; DNA binding site 699034002295 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034002296 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034002297 Walker A/P-loop; other site 699034002298 ATP binding site [chemical binding]; other site 699034002299 Q-loop/lid; other site 699034002300 ABC transporter signature motif; other site 699034002301 Walker B; other site 699034002302 D-loop; other site 699034002303 H-loop/switch region; other site 699034002304 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 699034002305 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034002306 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 699034002307 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 699034002308 putative Cl- selectivity filter; other site 699034002309 putative pore gating glutamate residue; other site 699034002310 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 699034002311 Helix-turn-helix domains; Region: HTH; cl00088 699034002312 clostridium toxin-associated regulator BotR; Region: P21_Cbot; TIGR03209 699034002313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034002314 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 699034002315 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 699034002316 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 699034002317 Peptidase C80 family; Region: Peptidase_C80; pfam11713 699034002318 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 699034002319 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 699034002320 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 699034002321 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 699034002322 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 699034002323 Holin family; Region: Phage_holin_4; cl01989 699034002324 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 699034002325 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 699034002326 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 699034002327 Peptidase C80 family; Region: Peptidase_C80; pfam11713 699034002328 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 699034002329 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 699034002330 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 699034002331 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 699034002332 TfoX N-terminal domain; Region: TfoX_N; cl01167 699034002333 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 699034002334 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034002335 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 699034002336 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034002337 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 699034002338 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 699034002339 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 699034002340 Walker A/P-loop; other site 699034002341 ATP binding site [chemical binding]; other site 699034002342 Q-loop/lid; other site 699034002343 ABC transporter signature motif; other site 699034002344 Walker B; other site 699034002345 D-loop; other site 699034002346 H-loop/switch region; other site 699034002347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034002348 dimer interface [polypeptide binding]; other site 699034002349 phosphorylation site [posttranslational modification] 699034002350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034002351 ATP binding site [chemical binding]; other site 699034002352 Mg2+ binding site [ion binding]; other site 699034002353 G-X-G motif; other site 699034002354 Helix-turn-helix domains; Region: HTH; cl00088 699034002355 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 699034002356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 699034002357 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 699034002358 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 699034002359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034002360 S-adenosylmethionine binding site [chemical binding]; other site 699034002361 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 699034002362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034002363 Coenzyme A binding pocket [chemical binding]; other site 699034002364 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 699034002365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034002366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034002367 DNA binding residues [nucleotide binding] 699034002368 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 699034002369 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 699034002370 active site 699034002371 putative substrate binding pocket [chemical binding]; other site 699034002372 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034002373 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 699034002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034002375 benzoate transport; Region: 2A0115; TIGR00895 699034002376 putative substrate translocation pore; other site 699034002377 potential frameshift: common BLAST hit: gi|126698261|ref|YP_001087158.1| sodium:solute symporter 699034002378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 699034002379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 699034002380 DNA binding site [nucleotide binding] 699034002381 domain linker motif; other site 699034002382 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 699034002383 putative ligand binding site [chemical binding]; other site 699034002384 putative dimerization interface [polypeptide binding]; other site 699034002385 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 699034002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034002387 Walker A motif; other site 699034002388 ATP binding site [chemical binding]; other site 699034002389 Walker B motif; other site 699034002390 arginine finger; other site 699034002391 Peptidase family M41; Region: Peptidase_M41; pfam01434 699034002392 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 699034002393 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 699034002394 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 699034002395 ribosomal protein L20; Region: rpl20; CHL00068 699034002396 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 699034002397 23S rRNA binding site [nucleotide binding]; other site 699034002398 L21 binding site [polypeptide binding]; other site 699034002399 L13 binding site [polypeptide binding]; other site 699034002400 Helix-turn-helix domains; Region: HTH; cl00088 699034002401 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034002402 active site 699034002403 metal binding site [ion binding]; metal-binding site 699034002404 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034002405 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 699034002406 active site 699034002407 metal binding site [ion binding]; metal-binding site 699034002408 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034002409 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 699034002410 active site 699034002411 metal binding site [ion binding]; metal-binding site 699034002412 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 699034002413 active site 699034002414 metal binding site [ion binding]; metal-binding site 699034002415 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 699034002416 classical (c) SDRs; Region: SDR_c; cd05233 699034002417 NAD(P) binding site [chemical binding]; other site 699034002418 active site 699034002419 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034002420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034002421 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 699034002422 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 699034002423 DNA binding residues [nucleotide binding] 699034002424 drug binding residues [chemical binding]; other site 699034002425 dimer interface [polypeptide binding]; other site 699034002426 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034002427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034002428 Helix-turn-helix domains; Region: HTH; cl00088 699034002429 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 699034002430 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 699034002431 active site 699034002432 Zn binding site [ion binding]; other site 699034002433 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 699034002434 Cation transport protein; Region: TrkH; cl10514 699034002435 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 699034002436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034002437 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 699034002438 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 699034002439 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 699034002440 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 699034002441 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 699034002442 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 699034002443 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 699034002444 dimer interface [polypeptide binding]; other site 699034002445 motif 1; other site 699034002446 active site 699034002447 motif 2; other site 699034002448 motif 3; other site 699034002449 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 699034002450 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 699034002451 putative tRNA-binding site [nucleotide binding]; other site 699034002452 B3/4 domain; Region: B3_4; cl11458 699034002453 tRNA synthetase B5 domain; Region: B5; cl08394 699034002454 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 699034002455 dimer interface [polypeptide binding]; other site 699034002456 motif 1; other site 699034002457 motif 3; other site 699034002458 motif 2; other site 699034002459 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 699034002460 Cell division protein ZapA; Region: ZapA; cl01146 699034002461 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 699034002462 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 699034002463 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 699034002464 Peptidase family U32; Region: Peptidase_U32; cl03113 699034002465 Collagenase; Region: DUF3656; pfam12392 699034002466 Peptidase family U32; Region: Peptidase_U32; cl03113 699034002467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034002468 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 699034002469 putative active site [active] 699034002470 nucleotide binding site [chemical binding]; other site 699034002471 nudix motif; other site 699034002472 putative metal binding site [ion binding]; other site 699034002473 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 699034002474 4Fe-4S binding domain; Region: Fer4; cl02805 699034002475 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034002476 FMN binding site [chemical binding]; other site 699034002477 dimer interface [polypeptide binding]; other site 699034002478 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 699034002479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034002480 substrate binding pocket [chemical binding]; other site 699034002481 membrane-bound complex binding site; other site 699034002482 hinge residues; other site 699034002483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034002484 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 699034002485 substrate binding pocket [chemical binding]; other site 699034002486 membrane-bound complex binding site; other site 699034002487 hinge residues; other site 699034002488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034002489 metal binding site [ion binding]; metal-binding site 699034002490 active site 699034002491 I-site; other site 699034002492 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 699034002493 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 699034002494 metal binding site [ion binding]; metal-binding site 699034002495 dimer interface [polypeptide binding]; other site 699034002496 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 699034002497 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 699034002498 Walker A/P-loop; other site 699034002499 ATP binding site [chemical binding]; other site 699034002500 Q-loop/lid; other site 699034002501 ABC transporter signature motif; other site 699034002502 Walker B; other site 699034002503 D-loop; other site 699034002504 H-loop/switch region; other site 699034002505 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 699034002506 Smr domain; Region: Smr; cl02619 699034002507 Protein of unknown function (DUF523); Region: DUF523; cl00733 699034002508 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 699034002509 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 699034002510 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 699034002511 active site 699034002512 HIGH motif; other site 699034002513 KMSK motif region; other site 699034002514 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 699034002515 tRNA binding surface [nucleotide binding]; other site 699034002516 anticodon binding site; other site 699034002517 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 699034002518 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 699034002519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034002520 FeS/SAM binding site; other site 699034002521 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 699034002522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034002523 binding surface 699034002524 TPR motif; other site 699034002525 TPR repeat; Region: TPR_11; pfam13414 699034002526 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 699034002527 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 699034002528 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 699034002529 ACS interaction site; other site 699034002530 CODH interaction site; other site 699034002531 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 699034002532 cubane metal cluster (B-cluster) [ion binding]; other site 699034002533 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 699034002534 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 699034002535 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 699034002536 P-loop; other site 699034002537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002538 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 699034002539 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 699034002540 Potassium binding sites [ion binding]; other site 699034002541 Cesium cation binding sites [ion binding]; other site 699034002542 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 699034002543 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 699034002544 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 699034002545 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 699034002546 homodimer interface [polypeptide binding]; other site 699034002547 NADP binding site [chemical binding]; other site 699034002548 substrate binding site [chemical binding]; other site 699034002549 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 699034002550 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 699034002551 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 699034002552 FAD binding site [chemical binding]; other site 699034002553 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 699034002554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034002555 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 699034002556 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 699034002557 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 699034002558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002559 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 699034002560 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 699034002561 Putative Fe-S cluster; Region: FeS; pfam04060 699034002562 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 699034002563 substrate binding pocket [chemical binding]; other site 699034002564 dimer interface [polypeptide binding]; other site 699034002565 inhibitor binding site; inhibition site 699034002566 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 699034002567 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034002568 metal cluster binding site [ion binding]; other site 699034002569 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685 699034002570 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 699034002571 lipoyl attachment site [posttranslational modification]; other site 699034002572 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 699034002573 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 699034002574 catalytic loop [active] 699034002575 iron binding site [ion binding]; other site 699034002576 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 699034002577 catalytic site [active] 699034002578 metal binding site [ion binding]; metal-binding site 699034002579 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 699034002580 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 699034002581 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 699034002582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034002583 FeS/SAM binding site; other site 699034002584 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 699034002585 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 699034002586 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 699034002587 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 699034002588 histidinol-phosphatase; Reviewed; Region: PRK08123 699034002589 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 699034002590 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 699034002591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034002592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034002593 catalytic residue [active] 699034002594 glycerol kinase; Provisional; Region: glpK; PRK00047 699034002595 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 699034002596 N- and C-terminal domain interface [polypeptide binding]; other site 699034002597 active site 699034002598 MgATP binding site [chemical binding]; other site 699034002599 catalytic site [active] 699034002600 metal binding site [ion binding]; metal-binding site 699034002601 glycerol binding site [chemical binding]; other site 699034002602 homotetramer interface [polypeptide binding]; other site 699034002603 homodimer interface [polypeptide binding]; other site 699034002604 FBP binding site [chemical binding]; other site 699034002605 protein IIAGlc interface [polypeptide binding]; other site 699034002606 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 699034002607 Helix-turn-helix domains; Region: HTH; cl00088 699034002608 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034002609 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 699034002610 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 699034002611 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 699034002612 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 699034002613 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 699034002614 ligand binding site [chemical binding]; other site 699034002615 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 699034002616 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034002617 metal binding site [ion binding]; metal-binding site 699034002618 active site 699034002619 I-site; other site 699034002620 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034002621 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 699034002622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002623 Family description; Region: UvrD_C_2; cl15862 699034002624 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 699034002625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034002626 substrate binding pocket [chemical binding]; other site 699034002627 membrane-bound complex binding site; other site 699034002628 hinge residues; other site 699034002629 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 699034002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034002631 dimer interface [polypeptide binding]; other site 699034002632 conserved gate region; other site 699034002633 putative PBP binding loops; other site 699034002634 ABC-ATPase subunit interface; other site 699034002635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 699034002636 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 699034002637 Walker A/P-loop; other site 699034002638 ATP binding site [chemical binding]; other site 699034002639 Q-loop/lid; other site 699034002640 ABC transporter signature motif; other site 699034002641 Walker B; other site 699034002642 D-loop; other site 699034002643 H-loop/switch region; other site 699034002644 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034002645 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 699034002646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034002647 catalytic residue [active] 699034002648 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 699034002649 THUMP domain; Region: THUMP; cl12076 699034002650 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 699034002651 Ligand Binding Site [chemical binding]; other site 699034002652 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034002653 FMN binding site [chemical binding]; other site 699034002654 dimer interface [polypeptide binding]; other site 699034002655 PAS fold; Region: PAS_3; pfam08447 699034002656 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034002657 metal binding site [ion binding]; metal-binding site 699034002658 active site 699034002659 I-site; other site 699034002660 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034002661 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 699034002662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034002663 FeS/SAM binding site; other site 699034002664 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 699034002665 Pyruvate formate lyase 1; Region: PFL1; cd01678 699034002666 coenzyme A binding site [chemical binding]; other site 699034002667 active site 699034002668 catalytic residues [active] 699034002669 glycine loop; other site 699034002670 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 699034002671 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 699034002672 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 699034002673 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 699034002674 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 699034002675 ATP binding site [chemical binding]; other site 699034002676 Mg++ binding site [ion binding]; other site 699034002677 motif III; other site 699034002678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034002679 nucleotide binding region [chemical binding]; other site 699034002680 ATP-binding site [chemical binding]; other site 699034002681 DbpA RNA binding domain; Region: DbpA; pfam03880 699034002682 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034002683 Helix-turn-helix domains; Region: HTH; cl00088 699034002684 Helix-turn-helix domains; Region: HTH; cl00088 699034002685 PRD domain; Region: PRD; cl15445 699034002686 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034002687 active site 699034002688 P-loop; other site 699034002689 phosphorylation site [posttranslational modification] 699034002690 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034002691 active site 699034002692 phosphorylation site [posttranslational modification] 699034002693 Glucitol operon activator protein (GutM); Region: GutM; cl01890 699034002694 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 699034002695 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 699034002696 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 699034002697 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 699034002698 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 699034002699 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 699034002700 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 699034002701 putative NAD(P) binding site [chemical binding]; other site 699034002702 active site 699034002703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034002704 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034002705 Probable transposase; Region: OrfB_IS605; pfam01385 699034002706 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034002707 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 699034002708 molybdopterin cofactor binding site; other site 699034002709 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 699034002710 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 699034002711 molybdopterin cofactor binding site; other site 699034002712 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 699034002713 anti sigma factor interaction site; other site 699034002714 regulatory phosphorylation site [posttranslational modification]; other site 699034002715 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 699034002716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034002717 ATP binding site [chemical binding]; other site 699034002718 Mg2+ binding site [ion binding]; other site 699034002719 G-X-G motif; other site 699034002720 sporulation sigma factor SigF; Validated; Region: PRK05572 699034002721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034002722 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 699034002723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034002724 DNA binding residues [nucleotide binding] 699034002725 SpoVA protein; Region: SpoVA; cl04298 699034002726 stage V sporulation protein AD; Validated; Region: PRK08304 699034002727 stage V sporulation protein AD; Provisional; Region: PRK12404 699034002728 SpoVA protein; Region: SpoVA; cl04298 699034002729 Transcriptional regulators [Transcription]; Region: PurR; COG1609 699034002730 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 699034002731 DNA binding site [nucleotide binding] 699034002732 domain linker motif; other site 699034002733 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 699034002734 ligand binding site [chemical binding]; other site 699034002735 dimerization interface [polypeptide binding]; other site 699034002736 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 699034002737 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 699034002738 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 699034002739 active site 699034002740 catalytic motif [active] 699034002741 Zn binding site [ion binding]; other site 699034002742 Transglycosylase; Region: Transgly; cl07896 699034002743 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 699034002744 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034002745 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 699034002746 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 699034002747 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 699034002748 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034002749 active site 699034002750 metal binding site [ion binding]; metal-binding site 699034002751 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 699034002752 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002753 Walker A/P-loop; other site 699034002754 ATP binding site [chemical binding]; other site 699034002755 Q-loop/lid; other site 699034002756 ABC transporter signature motif; other site 699034002757 Walker B; other site 699034002758 D-loop; other site 699034002759 H-loop/switch region; other site 699034002760 ABC transporter; Region: ABC_tran_2; pfam12848 699034002761 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034002762 Cysteine-rich small domain; Region: zf-like; cl00946 699034002763 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 699034002764 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 699034002765 HflX GTPase family; Region: HflX; cd01878 699034002766 G1 box; other site 699034002767 GTP/Mg2+ binding site [chemical binding]; other site 699034002768 Switch I region; other site 699034002769 G2 box; other site 699034002770 G3 box; other site 699034002771 Switch II region; other site 699034002772 G4 box; other site 699034002773 G5 box; other site 699034002774 HEAT repeats; Region: HEAT_2; pfam13646 699034002775 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 699034002776 active site 699034002777 Ap6A binding site [chemical binding]; other site 699034002778 nudix motif; other site 699034002779 metal binding site [ion binding]; metal-binding site 699034002780 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 699034002781 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 699034002782 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 699034002783 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 699034002784 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 699034002785 NAD synthase; Region: NAD_synthase; pfam02540 699034002786 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 699034002787 homodimer interface [polypeptide binding]; other site 699034002788 NAD binding pocket [chemical binding]; other site 699034002789 ATP binding pocket [chemical binding]; other site 699034002790 Mg binding site [ion binding]; other site 699034002791 active-site loop [active] 699034002792 Transcriptional regulator; Region: Transcrip_reg; cl00361 699034002793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 699034002794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 699034002795 DNA binding site [nucleotide binding] 699034002796 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 699034002797 putative dimerization interface [polypeptide binding]; other site 699034002798 putative ligand binding site [chemical binding]; other site 699034002799 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 699034002800 active site 699034002801 catalytic residues [active] 699034002802 metal binding site [ion binding]; metal-binding site 699034002803 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 699034002804 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 699034002805 CoA-transferase family III; Region: CoA_transf_3; pfam02515 699034002806 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 699034002807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 699034002808 substrate binding site [chemical binding]; other site 699034002809 oxyanion hole (OAH) forming residues; other site 699034002810 trimer interface [polypeptide binding]; other site 699034002811 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 699034002812 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 699034002813 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 699034002814 CoA-transferase family III; Region: CoA_transf_3; pfam02515 699034002815 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 699034002816 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 699034002817 active site 699034002818 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 699034002819 Ligand binding site [chemical binding]; other site 699034002820 Electron transfer flavoprotein domain; Region: ETF; pfam01012 699034002821 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 699034002822 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 699034002823 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 699034002824 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 699034002825 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 699034002826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034002827 Walker A motif; other site 699034002828 ATP binding site [chemical binding]; other site 699034002829 Walker B motif; other site 699034002830 arginine finger; other site 699034002831 Helix-turn-helix domains; Region: HTH; cl00088 699034002832 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034002833 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034002834 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034002835 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034002836 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034002837 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034002838 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034002839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034002840 metal binding site [ion binding]; metal-binding site 699034002841 active site 699034002842 I-site; other site 699034002843 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034002844 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 699034002845 Ligand Binding Site [chemical binding]; other site 699034002846 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 699034002847 Transcriptional regulators [Transcription]; Region: FadR; COG2186 699034002848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034002849 DNA-binding site [nucleotide binding]; DNA binding site 699034002850 FCD domain; Region: FCD; cl11656 699034002851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034002852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034002853 putative substrate translocation pore; other site 699034002854 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 699034002855 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034002856 active site turn [active] 699034002857 phosphorylation site [posttranslational modification] 699034002858 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034002859 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 699034002860 HPr interaction site; other site 699034002861 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034002862 active site 699034002863 phosphorylation site [posttranslational modification] 699034002864 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034002865 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034002866 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034002867 PRD domain; Region: PRD; cl15445 699034002868 PRD domain; Region: PRD; cl15445 699034002869 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 699034002870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034002871 active site 699034002872 phosphorylation site [posttranslational modification] 699034002873 intermolecular recognition site; other site 699034002874 dimerization interface [polypeptide binding]; other site 699034002875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034002876 DNA binding site [nucleotide binding] 699034002877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034002878 dimer interface [polypeptide binding]; other site 699034002879 phosphorylation site [posttranslational modification] 699034002880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034002881 ATP binding site [chemical binding]; other site 699034002882 Mg2+ binding site [ion binding]; other site 699034002883 G-X-G motif; other site 699034002884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034002885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034002886 Walker A/P-loop; other site 699034002887 ATP binding site [chemical binding]; other site 699034002888 Q-loop/lid; other site 699034002889 ABC transporter signature motif; other site 699034002890 Walker B; other site 699034002891 D-loop; other site 699034002892 H-loop/switch region; other site 699034002893 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034002894 Rubrerythrin [Energy production and conversion]; Region: COG1592 699034002895 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 699034002896 binuclear metal center [ion binding]; other site 699034002897 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 699034002898 iron binding site [ion binding]; other site 699034002899 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 699034002900 metal binding site 2 [ion binding]; metal-binding site 699034002901 putative DNA binding helix; other site 699034002902 metal binding site 1 [ion binding]; metal-binding site 699034002903 dimer interface [polypeptide binding]; other site 699034002904 structural Zn2+ binding site [ion binding]; other site 699034002905 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 699034002906 Desulfoferrodoxin [Energy production and conversion]; Region: COG2033 699034002907 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 699034002908 non-heme iron binding site [ion binding]; other site 699034002909 Rubredoxin [Energy production and conversion]; Region: COG1773 699034002910 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 699034002911 iron binding site [ion binding]; other site 699034002912 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 699034002913 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 699034002914 active site 699034002915 FMN binding site [chemical binding]; other site 699034002916 substrate binding site [chemical binding]; other site 699034002917 3Fe-4S cluster binding site [ion binding]; other site 699034002918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034002919 Uncharacterized membrane protein [Function unknown]; Region: COG3949 699034002920 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 699034002921 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 699034002922 DEAD-like helicases superfamily; Region: DEXDc; smart00487 699034002923 ATP binding site [chemical binding]; other site 699034002924 Mg++ binding site [ion binding]; other site 699034002925 motif III; other site 699034002926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034002927 nucleotide binding region [chemical binding]; other site 699034002928 ATP-binding site [chemical binding]; other site 699034002929 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 699034002930 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 699034002931 active site 699034002932 catalytic residues [active] 699034002933 metal binding site [ion binding]; metal-binding site 699034002934 aconitate hydratase; Validated; Region: PRK07229 699034002935 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 699034002936 substrate binding site [chemical binding]; other site 699034002937 ligand binding site [chemical binding]; other site 699034002938 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 699034002939 substrate binding site [chemical binding]; other site 699034002940 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 699034002941 isocitrate dehydrogenase; Validated; Region: PRK06451 699034002942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034002943 Helix-turn-helix domains; Region: HTH; cl00088 699034002944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 699034002945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034002946 Coenzyme A binding pocket [chemical binding]; other site 699034002947 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034002948 FMN binding site [chemical binding]; other site 699034002949 dimer interface [polypeptide binding]; other site 699034002950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034002951 DNA binding site [nucleotide binding] 699034002952 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 699034002953 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 699034002954 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 699034002955 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034002956 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034002957 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034002958 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 699034002959 GIY-YIG motif/motif A; other site 699034002960 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 699034002961 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 699034002962 amidohydrolase; Region: amidohydrolases; TIGR01891 699034002963 putative metal binding site [ion binding]; other site 699034002964 NifU-like domain; Region: NifU; cl00484 699034002965 TIGR03987 family protein; Region: TIGR03987 699034002966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034002967 Helix-turn-helix domains; Region: HTH; cl00088 699034002968 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 699034002969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034002970 dimer interface [polypeptide binding]; other site 699034002971 conserved gate region; other site 699034002972 putative PBP binding loops; other site 699034002973 ABC-ATPase subunit interface; other site 699034002974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034002975 dimer interface [polypeptide binding]; other site 699034002976 conserved gate region; other site 699034002977 putative PBP binding loops; other site 699034002978 ABC-ATPase subunit interface; other site 699034002979 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 699034002980 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 699034002981 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 699034002982 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 699034002983 Walker A/P-loop; other site 699034002984 ATP binding site [chemical binding]; other site 699034002985 Q-loop/lid; other site 699034002986 ABC transporter signature motif; other site 699034002987 Walker B; other site 699034002988 D-loop; other site 699034002989 H-loop/switch region; other site 699034002990 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 699034002991 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 699034002992 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 699034002993 Walker A/P-loop; other site 699034002994 ATP binding site [chemical binding]; other site 699034002995 Q-loop/lid; other site 699034002996 ABC transporter signature motif; other site 699034002997 Walker B; other site 699034002998 D-loop; other site 699034002999 H-loop/switch region; other site 699034003000 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 699034003001 'potential frameshift: common BLAST hit: gi|260686156|ref|YP_003217289.1| sigma-54 factor, interaction domain-containing' 699034003002 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 699034003003 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034003004 active site 699034003005 P-loop; other site 699034003006 phosphorylation site [posttranslational modification] 699034003007 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034003008 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 699034003009 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 699034003010 methionine cluster; other site 699034003011 active site 699034003012 phosphorylation site [posttranslational modification] 699034003013 metal binding site [ion binding]; metal-binding site 699034003014 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 699034003015 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 699034003016 NAD binding site [chemical binding]; other site 699034003017 sugar binding site [chemical binding]; other site 699034003018 divalent metal binding site [ion binding]; other site 699034003019 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034003020 dimer interface [polypeptide binding]; other site 699034003021 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 699034003022 ADP-ribose binding site [chemical binding]; other site 699034003023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034003024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034003025 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 699034003026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034003027 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 699034003028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034003029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034003030 dimer interface [polypeptide binding]; other site 699034003031 conserved gate region; other site 699034003032 putative PBP binding loops; other site 699034003033 ABC-ATPase subunit interface; other site 699034003034 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 699034003035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003036 Walker A/P-loop; other site 699034003037 ATP binding site [chemical binding]; other site 699034003038 Q-loop/lid; other site 699034003039 ABC transporter signature motif; other site 699034003040 Walker B; other site 699034003041 D-loop; other site 699034003042 H-loop/switch region; other site 699034003043 maltose O-acetyltransferase; Provisional; Region: PRK10092 699034003044 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 699034003045 active site 699034003046 substrate binding site [chemical binding]; other site 699034003047 trimer interface [polypeptide binding]; other site 699034003048 CoA binding site [chemical binding]; other site 699034003049 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 699034003050 zinc binding site [ion binding]; other site 699034003051 putative ligand binding site [chemical binding]; other site 699034003052 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 699034003053 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003054 Walker A/P-loop; other site 699034003055 ATP binding site [chemical binding]; other site 699034003056 Q-loop/lid; other site 699034003057 ABC transporter signature motif; other site 699034003058 Walker B; other site 699034003059 D-loop; other site 699034003060 H-loop/switch region; other site 699034003061 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 699034003062 TM-ABC transporter signature motif; other site 699034003063 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 699034003064 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 699034003065 zinc binding site [ion binding]; other site 699034003066 putative ligand binding site [chemical binding]; other site 699034003067 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 699034003068 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003069 Walker A/P-loop; other site 699034003070 ATP binding site [chemical binding]; other site 699034003071 Q-loop/lid; other site 699034003072 ABC transporter signature motif; other site 699034003073 Walker B; other site 699034003074 D-loop; other site 699034003075 H-loop/switch region; other site 699034003076 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 699034003077 TM-ABC transporter signature motif; other site 699034003078 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 699034003079 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 699034003080 putative substrate binding site [chemical binding]; other site 699034003081 putative ATP binding site [chemical binding]; other site 699034003082 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034003083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034003084 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034003085 Probable transposase; Region: OrfB_IS605; pfam01385 699034003086 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034003087 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 699034003088 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 699034003089 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 699034003090 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 699034003091 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 699034003092 ligand binding site; other site 699034003093 oligomer interface; other site 699034003094 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 699034003095 dimer interface [polypeptide binding]; other site 699034003096 N-terminal domain interface [polypeptide binding]; other site 699034003097 sulfate 1 binding site; other site 699034003098 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 699034003099 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 699034003100 ligand binding site; other site 699034003101 oligomer interface; other site 699034003102 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 699034003103 dimer interface [polypeptide binding]; other site 699034003104 N-terminal domain interface [polypeptide binding]; other site 699034003105 sulfate 1 binding site; other site 699034003106 glycogen synthase; Provisional; Region: glgA; PRK00654 699034003107 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 699034003108 ADP-binding pocket [chemical binding]; other site 699034003109 homodimer interface [polypeptide binding]; other site 699034003110 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 699034003111 homodimer interface [polypeptide binding]; other site 699034003112 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 699034003113 active site pocket [active] 699034003114 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 699034003115 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 699034003116 active site 699034003117 homodimer interface [polypeptide binding]; other site 699034003118 catalytic site [active] 699034003119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034003120 DNA-binding site [nucleotide binding]; DNA binding site 699034003121 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 699034003122 FCD domain; Region: FCD; cl11656 699034003123 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 699034003124 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034003125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034003126 catalytic residue [active] 699034003127 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 699034003128 spermidine synthase; Provisional; Region: PRK00811 699034003129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034003130 S-adenosylmethionine binding site [chemical binding]; other site 699034003131 Arginase family; Region: Arginase; cl00306 699034003132 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 699034003133 DNA-binding site [nucleotide binding]; DNA binding site 699034003134 RNA-binding motif; other site 699034003135 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 699034003136 4Fe-4S binding domain; Region: Fer4; cl02805 699034003137 4Fe-4S binding domain; Region: Fer4; cl02805 699034003138 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 699034003139 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 699034003140 4Fe-4S binding domain; Region: Fer4; cl02805 699034003141 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 699034003142 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034003144 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034003145 Probable transposase; Region: OrfB_IS605; pfam01385 699034003146 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034003147 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034003148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 699034003149 hypothetical protein; Provisional; Region: PRK13663 699034003150 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 699034003151 active site 699034003152 DNA polymerase IV; Validated; Region: PRK02406 699034003153 DNA binding site [nucleotide binding] 699034003154 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 699034003155 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 699034003156 Walker A/P-loop; other site 699034003157 ATP binding site [chemical binding]; other site 699034003158 Q-loop/lid; other site 699034003159 ABC transporter signature motif; other site 699034003160 Walker B; other site 699034003161 D-loop; other site 699034003162 H-loop/switch region; other site 699034003163 FOG: CBS domain [General function prediction only]; Region: COG0517 699034003164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 699034003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034003166 dimer interface [polypeptide binding]; other site 699034003167 conserved gate region; other site 699034003168 putative PBP binding loops; other site 699034003169 ABC-ATPase subunit interface; other site 699034003170 NMT1-like family; Region: NMT1_2; cl15260 699034003171 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 699034003172 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 699034003173 Cation efflux family; Region: Cation_efflux; cl00316 699034003174 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 699034003175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 699034003176 active site 699034003177 catalytic tetrad [active] 699034003178 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034003179 UbiA prenyltransferase family; Region: UbiA; cl00337 699034003180 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034003181 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 699034003182 putative efflux protein, MATE family; Region: matE; TIGR00797 699034003183 MatE; Region: MatE; cl10513 699034003184 MatE; Region: MatE; cl10513 699034003185 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 699034003186 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 699034003187 RNA binding site [nucleotide binding]; other site 699034003188 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 699034003189 RNA binding site [nucleotide binding]; other site 699034003190 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 699034003191 RNA binding site [nucleotide binding]; other site 699034003192 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034003193 RNA binding site [nucleotide binding]; other site 699034003194 putative hydrolase; Validated; Region: PRK09248 699034003195 2-isopropylmalate synthase; Validated; Region: PRK03739 699034003196 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 699034003197 active site 699034003198 catalytic residues [active] 699034003199 metal binding site [ion binding]; metal-binding site 699034003200 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 699034003201 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 699034003202 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 699034003203 substrate binding site [chemical binding]; other site 699034003204 ligand binding site [chemical binding]; other site 699034003205 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 699034003206 substrate binding site [chemical binding]; other site 699034003207 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 699034003208 tartrate dehydrogenase; Provisional; Region: PRK08194 699034003209 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 699034003210 CoenzymeA binding site [chemical binding]; other site 699034003211 subunit interaction site [polypeptide binding]; other site 699034003212 PHB binding site; other site 699034003213 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 699034003214 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034003215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034003216 catalytic residue [active] 699034003217 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 699034003218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034003219 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 699034003220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034003221 PAS fold; Region: PAS_3; pfam08447 699034003222 putative active site [active] 699034003223 heme pocket [chemical binding]; other site 699034003224 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 699034003225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034003226 putative active site [active] 699034003227 heme pocket [chemical binding]; other site 699034003228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034003229 metal binding site [ion binding]; metal-binding site 699034003230 active site 699034003231 I-site; other site 699034003232 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 699034003233 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 699034003234 hypothetical protein; Provisional; Region: PRK00955 699034003235 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 699034003236 NMT1-like family; Region: NMT1_2; cl15260 699034003237 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 699034003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034003239 dimer interface [polypeptide binding]; other site 699034003240 conserved gate region; other site 699034003241 putative PBP binding loops; other site 699034003242 ABC-ATPase subunit interface; other site 699034003243 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 699034003244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034003245 Walker A/P-loop; other site 699034003246 ATP binding site [chemical binding]; other site 699034003247 Q-loop/lid; other site 699034003248 ABC transporter signature motif; other site 699034003249 Walker B; other site 699034003250 D-loop; other site 699034003251 H-loop/switch region; other site 699034003252 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 699034003253 putative deacylase active site [active] 699034003254 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 699034003255 Fumarase C-terminus; Region: Fumerase_C; cl00795 699034003256 Malic enzyme, N-terminal domain; Region: malic; pfam00390 699034003257 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 699034003258 putative NAD(P) binding site [chemical binding]; other site 699034003259 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 699034003260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034003261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034003262 active site 699034003263 phosphorylation site [posttranslational modification] 699034003264 intermolecular recognition site; other site 699034003265 dimerization interface [polypeptide binding]; other site 699034003266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034003267 DNA binding site [nucleotide binding] 699034003268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034003269 dimer interface [polypeptide binding]; other site 699034003270 phosphorylation site [posttranslational modification] 699034003271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034003272 ATP binding site [chemical binding]; other site 699034003273 Mg2+ binding site [ion binding]; other site 699034003274 G-X-G motif; other site 699034003275 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034003276 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034003277 Walker A/P-loop; other site 699034003278 ATP binding site [chemical binding]; other site 699034003279 Q-loop/lid; other site 699034003280 ABC transporter signature motif; other site 699034003281 Walker B; other site 699034003282 D-loop; other site 699034003283 H-loop/switch region; other site 699034003284 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034003285 FtsX-like permease family; Region: FtsX; cl15850 699034003286 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034003287 FtsX-like permease family; Region: FtsX; cl15850 699034003288 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 699034003289 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034003290 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034003291 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 699034003292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034003293 DNA-binding site [nucleotide binding]; DNA binding site 699034003294 UTRA domain; Region: UTRA; cl01230 699034003295 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 699034003296 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 699034003297 active site 699034003298 dimer interface [polypeptide binding]; other site 699034003299 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 699034003300 active site 699034003301 trimer interface [polypeptide binding]; other site 699034003302 allosteric site; other site 699034003303 active site lid [active] 699034003304 hexamer (dimer of trimers) interface [polypeptide binding]; other site 699034003305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034003306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034003307 active site 699034003308 phosphorylation site [posttranslational modification] 699034003309 intermolecular recognition site; other site 699034003310 dimerization interface [polypeptide binding]; other site 699034003311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034003312 DNA binding site [nucleotide binding] 699034003313 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034003314 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034003315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034003316 dimer interface [polypeptide binding]; other site 699034003317 phosphorylation site [posttranslational modification] 699034003318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034003319 ATP binding site [chemical binding]; other site 699034003320 Mg2+ binding site [ion binding]; other site 699034003321 G-X-G motif; other site 699034003322 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 699034003323 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 699034003324 DNA binding residues [nucleotide binding] 699034003325 dimer interface [polypeptide binding]; other site 699034003326 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034003327 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034003328 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034003329 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003330 Walker A/P-loop; other site 699034003331 ATP binding site [chemical binding]; other site 699034003332 Q-loop/lid; other site 699034003333 ABC transporter signature motif; other site 699034003334 Walker B; other site 699034003335 D-loop; other site 699034003336 H-loop/switch region; other site 699034003337 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034003338 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034003339 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 699034003340 Walker A/P-loop; other site 699034003341 ATP binding site [chemical binding]; other site 699034003342 Q-loop/lid; other site 699034003343 ABC transporter signature motif; other site 699034003344 Walker B; other site 699034003345 D-loop; other site 699034003346 H-loop/switch region; other site 699034003347 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 699034003348 putative metal binding residues [ion binding]; other site 699034003349 signature motif; other site 699034003350 dimer interface [polypeptide binding]; other site 699034003351 active site 699034003352 polyP binding site; other site 699034003353 substrate binding site [chemical binding]; other site 699034003354 acceptor-phosphate pocket; other site 699034003355 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 699034003356 Predicted membrane protein [Function unknown]; Region: COG2364 699034003357 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 699034003358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034003359 non-specific DNA binding site [nucleotide binding]; other site 699034003360 salt bridge; other site 699034003361 sequence-specific DNA binding site [nucleotide binding]; other site 699034003362 Cupin domain; Region: Cupin_2; cl09118 699034003363 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 699034003364 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 699034003365 Walker A/P-loop; other site 699034003366 ATP binding site [chemical binding]; other site 699034003367 Q-loop/lid; other site 699034003368 ABC transporter signature motif; other site 699034003369 Walker B; other site 699034003370 D-loop; other site 699034003371 H-loop/switch region; other site 699034003372 TOBE domain; Region: TOBE_2; cl01440 699034003373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034003374 dimer interface [polypeptide binding]; other site 699034003375 conserved gate region; other site 699034003376 putative PBP binding loops; other site 699034003377 ABC-ATPase subunit interface; other site 699034003378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034003379 dimer interface [polypeptide binding]; other site 699034003380 conserved gate region; other site 699034003381 putative PBP binding loops; other site 699034003382 ABC-ATPase subunit interface; other site 699034003383 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 699034003384 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034003385 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 699034003386 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 699034003387 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 699034003388 NodB motif; other site 699034003389 putative active site [active] 699034003390 putative catalytic site [active] 699034003391 putative Zn binding site [ion binding]; other site 699034003392 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 699034003393 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 699034003394 DXD motif; other site 699034003395 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 699034003396 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 699034003397 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 699034003398 active site 699034003399 homodimer interface [polypeptide binding]; other site 699034003400 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 699034003401 potential RNA of insufficient length (23S ribosomal RNA) 699034003402 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003403 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003404 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003405 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034003406 active site 699034003407 metal binding site [ion binding]; metal-binding site 699034003408 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003409 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003410 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003411 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034003412 active site 699034003413 metal binding site [ion binding]; metal-binding site 699034003414 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 699034003415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003416 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 699034003417 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 699034003418 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 699034003419 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 699034003420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003421 Family description; Region: UvrD_C_2; cl15862 699034003422 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 699034003423 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 699034003424 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 699034003425 active site 699034003426 metal binding site [ion binding]; metal-binding site 699034003427 DNA binding site [nucleotide binding] 699034003428 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 699034003429 exonuclease SbcC; Region: sbcc; TIGR00618 699034003430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003431 Walker A/P-loop; other site 699034003432 ATP binding site [chemical binding]; other site 699034003433 Q-loop/lid; other site 699034003434 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 699034003435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003436 ABC transporter signature motif; other site 699034003437 Walker B; other site 699034003438 D-loop; other site 699034003439 H-loop/switch region; other site 699034003440 Domain of unknown function DUF21; Region: DUF21; pfam01595 699034003441 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 699034003442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 699034003443 Transporter associated domain; Region: CorC_HlyC; cl08393 699034003444 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 699034003445 peptidase T; Region: peptidase-T; TIGR01882 699034003446 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 699034003447 metal binding site [ion binding]; metal-binding site 699034003448 dimer interface [polypeptide binding]; other site 699034003449 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003450 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003451 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003452 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 699034003453 active site 699034003454 metal binding site [ion binding]; metal-binding site 699034003455 homotetramer interface [polypeptide binding]; other site 699034003456 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 699034003457 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034003458 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034003459 Walker A/P-loop; other site 699034003460 ATP binding site [chemical binding]; other site 699034003461 Q-loop/lid; other site 699034003462 ABC transporter signature motif; other site 699034003463 Walker B; other site 699034003464 D-loop; other site 699034003465 H-loop/switch region; other site 699034003466 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 699034003467 putative deacylase active site [active] 699034003468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 699034003469 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 699034003470 FAD binding site [chemical binding]; other site 699034003471 homotetramer interface [polypeptide binding]; other site 699034003472 substrate binding pocket [chemical binding]; other site 699034003473 catalytic base [active] 699034003474 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 699034003475 Ligand binding site [chemical binding]; other site 699034003476 Electron transfer flavoprotein domain; Region: ETF; pfam01012 699034003477 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 699034003478 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 699034003479 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 699034003480 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 699034003481 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 699034003482 substrate binding site [chemical binding]; other site 699034003483 oxyanion hole (OAH) forming residues; other site 699034003484 trimer interface [polypeptide binding]; other site 699034003485 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 699034003486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034003487 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 699034003488 putative acyltransferase; Provisional; Region: PRK05790 699034003489 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 699034003490 dimer interface [polypeptide binding]; other site 699034003491 active site 699034003492 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 699034003493 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 699034003494 active site 699034003495 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 699034003496 Phosphopantetheine attachment site; Region: PP-binding; cl09936 699034003497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 699034003498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 699034003499 DNA binding site [nucleotide binding] 699034003500 domain linker motif; other site 699034003501 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 699034003502 dimerization interface [polypeptide binding]; other site 699034003503 effector binding site; other site 699034003504 MatE; Region: MatE; cl10513 699034003505 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 699034003506 MatE; Region: MatE; cl10513 699034003507 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 699034003508 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 699034003509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034003510 DNA-binding site [nucleotide binding]; DNA binding site 699034003511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034003512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034003513 homodimer interface [polypeptide binding]; other site 699034003514 catalytic residue [active] 699034003515 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 699034003516 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 699034003517 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 699034003518 oligomer interface [polypeptide binding]; other site 699034003519 putative active site [active] 699034003520 metal binding site [ion binding]; metal-binding site 699034003521 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 699034003522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034003523 DNA-binding site [nucleotide binding]; DNA binding site 699034003524 UTRA domain; Region: UTRA; cl01230 699034003525 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 699034003526 active pocket/dimerization site; other site 699034003527 active site 699034003528 phosphorylation site [posttranslational modification] 699034003529 BtpA family; Region: BtpA; cl00440 699034003530 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 699034003531 active site 699034003532 phosphorylation site [posttranslational modification] 699034003533 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 699034003534 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 699034003535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034003536 Helix-turn-helix domains; Region: HTH; cl00088 699034003537 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 699034003538 putative dimerization interface [polypeptide binding]; other site 699034003539 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 699034003540 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 699034003541 dimer interface [polypeptide binding]; other site 699034003542 putative functional site; other site 699034003543 putative MPT binding site; other site 699034003544 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 699034003545 Walker A motif; other site 699034003546 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 699034003547 active site 699034003548 P-loop; other site 699034003549 phosphorylation site [posttranslational modification] 699034003550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034003551 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034003552 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 699034003553 Walker A/P-loop; other site 699034003554 ATP binding site [chemical binding]; other site 699034003555 Q-loop/lid; other site 699034003556 ABC transporter signature motif; other site 699034003557 Walker B; other site 699034003558 D-loop; other site 699034003559 H-loop/switch region; other site 699034003560 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 699034003561 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034003562 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 699034003563 metal binding site [ion binding]; metal-binding site 699034003564 putative dimer interface [polypeptide binding]; other site 699034003565 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 699034003566 ZIP Zinc transporter; Region: Zip; pfam02535 699034003567 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 699034003568 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 699034003569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 699034003570 active site 699034003571 phosphorylation site [posttranslational modification] 699034003572 intermolecular recognition site; other site 699034003573 LytTr DNA-binding domain; Region: LytTR; cl04498 699034003574 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 699034003575 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 699034003576 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 699034003577 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 699034003578 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 699034003579 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 699034003580 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 699034003581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034003582 non-specific DNA binding site [nucleotide binding]; other site 699034003583 salt bridge; other site 699034003584 sequence-specific DNA binding site [nucleotide binding]; other site 699034003585 Cupin domain; Region: Cupin_2; cl09118 699034003586 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 699034003587 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 699034003588 putative active site [active] 699034003589 putative metal binding site [ion binding]; other site 699034003590 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 699034003591 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 699034003592 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034003593 FMN binding site [chemical binding]; other site 699034003594 dimer interface [polypeptide binding]; other site 699034003595 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034003596 FMN binding site [chemical binding]; other site 699034003597 dimer interface [polypeptide binding]; other site 699034003598 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034003599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034003600 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034003601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034003602 non-specific DNA binding site [nucleotide binding]; other site 699034003603 salt bridge; other site 699034003604 sequence-specific DNA binding site [nucleotide binding]; other site 699034003605 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034003606 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034003607 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034003608 Probable transposase; Region: OrfB_IS605; pfam01385 699034003609 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034003610 DHHW protein; Region: DHHW; pfam14286 699034003611 DHHW protein; Region: DHHW; pfam14286 699034003612 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 699034003613 DNA polymerase I; Provisional; Region: PRK05755 699034003614 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 699034003615 active site 699034003616 metal binding site 1 [ion binding]; metal-binding site 699034003617 putative 5' ssDNA interaction site; other site 699034003618 metal binding site 3; metal-binding site 699034003619 metal binding site 2 [ion binding]; metal-binding site 699034003620 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 699034003621 putative DNA binding site [nucleotide binding]; other site 699034003622 putative metal binding site [ion binding]; other site 699034003623 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 699034003624 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 699034003625 active site 699034003626 DNA binding site [nucleotide binding] 699034003627 catalytic site [active] 699034003628 dephospho-CoA kinase; Region: TIGR00152 699034003629 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 699034003630 CoA-binding site [chemical binding]; other site 699034003631 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 699034003632 N-acetyl-D-glucosamine binding site [chemical binding]; other site 699034003633 catalytic residue [active] 699034003634 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 699034003635 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 699034003636 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 699034003637 metal-binding site [ion binding] 699034003638 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 699034003639 dimer interface [polypeptide binding]; other site 699034003640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 699034003641 active site 699034003642 metal binding site [ion binding]; metal-binding site 699034003643 glutathione binding site [chemical binding]; other site 699034003644 Bacterial SH3 domain; Region: SH3_3; cl02551 699034003645 Bacterial SH3 domain; Region: SH3_3; cl02551 699034003646 Bacterial SH3 domain; Region: SH3_3; cl02551 699034003647 NlpC/P60 family; Region: NLPC_P60; cl11438 699034003648 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 699034003649 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 699034003650 SLBB domain; Region: SLBB; pfam10531 699034003651 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 699034003652 FMN-binding domain; Region: FMN_bind; cl01081 699034003653 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 699034003654 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 699034003655 ferredoxin; Validated; Region: PRK07118 699034003656 4Fe-4S binding domain; Region: Fer4; cl02805 699034003657 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 699034003658 4Fe-4S binding domain; Region: Fer4; cl02805 699034003659 Maf-like protein; Region: Maf; pfam02545 699034003660 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 699034003661 active site 699034003662 dimer interface [polypeptide binding]; other site 699034003663 hypothetical protein; Reviewed; Region: PRK00024 699034003664 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 699034003665 MPN+ (JAMM) motif; other site 699034003666 Zinc-binding site [ion binding]; other site 699034003667 rod shape-determining protein MreB; Provisional; Region: PRK13927 699034003668 Cell division protein FtsA; Region: FtsA; cl11496 699034003669 rod shape-determining protein MreC; Provisional; Region: PRK13922 699034003670 rod shape-determining protein MreC; Region: MreC; pfam04085 699034003671 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 699034003672 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 699034003673 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 699034003674 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034003675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034003676 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 699034003677 septum formation inhibitor; Reviewed; Region: minC; PRK00513 699034003678 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 699034003679 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 699034003680 septum site-determining protein MinD; Region: minD_bact; TIGR01968 699034003681 Switch I; other site 699034003682 Switch II; other site 699034003683 Septum formation topological specificity factor MinE; Region: MinE; cl00538 699034003684 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 699034003685 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 699034003686 active site 699034003687 dimer interfaces [polypeptide binding]; other site 699034003688 catalytic residues [active] 699034003689 Helix-turn-helix domains; Region: HTH; cl00088 699034003690 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 699034003691 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 699034003692 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034003693 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034003694 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 699034003695 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034003696 FeS/SAM binding site; other site 699034003697 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 699034003698 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 699034003699 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 699034003700 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 699034003701 homodimer interface [polypeptide binding]; other site 699034003702 oligonucleotide binding site [chemical binding]; other site 699034003703 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 699034003704 Protein of unknown function (DUF464); Region: DUF464; cl01080 699034003705 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 699034003706 GTPase CgtA; Reviewed; Region: obgE; PRK12297 699034003707 GTP1/OBG; Region: GTP1_OBG; pfam01018 699034003708 Obg GTPase; Region: Obg; cd01898 699034003709 G1 box; other site 699034003710 GTP/Mg2+ binding site [chemical binding]; other site 699034003711 Switch I region; other site 699034003712 G2 box; other site 699034003713 G3 box; other site 699034003714 Switch II region; other site 699034003715 G4 box; other site 699034003716 G5 box; other site 699034003717 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 699034003718 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 699034003719 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 699034003720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034003721 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 699034003722 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034003723 active site 699034003724 DNA binding site [nucleotide binding] 699034003725 Int/Topo IB signature motif; other site 699034003726 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 699034003727 Nucleoside recognition; Region: Gate; cl00486 699034003728 Transcriptional regulators [Transcription]; Region: FadR; COG2186 699034003729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034003730 DNA-binding site [nucleotide binding]; DNA binding site 699034003731 FCD domain; Region: FCD; cl11656 699034003732 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 699034003733 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 699034003734 Ligand binding site [chemical binding]; other site 699034003735 Electron transfer flavoprotein domain; Region: ETF; pfam01012 699034003736 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 699034003737 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 699034003738 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 699034003739 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 699034003740 FAD binding domain; Region: FAD_binding_4; pfam01565 699034003741 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 699034003742 Predicted nucleotidyltransferase [General function prediction only]; Region: COG1323 699034003743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 699034003744 Acetokinase family; Region: Acetate_kinase; cl01029 699034003745 acetate kinase; Region: ackA; TIGR00016 699034003746 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 699034003747 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 699034003748 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 699034003749 Helix-turn-helix domains; Region: HTH; cl00088 699034003750 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 699034003751 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 699034003752 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 699034003753 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 699034003754 dimer interface [polypeptide binding]; other site 699034003755 active site 699034003756 CoA binding pocket [chemical binding]; other site 699034003757 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 699034003758 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 699034003759 FMN binding site [chemical binding]; other site 699034003760 substrate binding site [chemical binding]; other site 699034003761 putative catalytic residue [active] 699034003762 Acyl transferase domain; Region: Acyl_transf_1; cl08282 699034003763 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 699034003764 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 699034003765 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 699034003766 NAD(P) binding site [chemical binding]; other site 699034003767 homotetramer interface [polypeptide binding]; other site 699034003768 homodimer interface [polypeptide binding]; other site 699034003769 active site 699034003770 Phosphopantetheine attachment site; Region: PP-binding; cl09936 699034003771 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 699034003772 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 699034003773 dimer interface [polypeptide binding]; other site 699034003774 active site 699034003775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 699034003776 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 699034003777 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034003778 metal binding site [ion binding]; metal-binding site 699034003779 active site 699034003780 I-site; other site 699034003781 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034003782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 699034003783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034003784 Walker A motif; other site 699034003785 ATP binding site [chemical binding]; other site 699034003786 Walker B motif; other site 699034003787 arginine finger; other site 699034003788 TSCPD domain; Region: TSCPD; cl14834 699034003789 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 699034003790 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 699034003791 catalytic triad [active] 699034003792 amino acid transporter; Region: 2A0306; TIGR00909 699034003793 Spore germination protein; Region: Spore_permease; cl15802 699034003794 Spore germination protein; Region: Spore_permease; cl15802 699034003795 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 699034003796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034003797 Coenzyme A binding pocket [chemical binding]; other site 699034003798 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 699034003799 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 699034003800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003801 Walker A motif; other site 699034003802 ATP binding site [chemical binding]; other site 699034003803 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 699034003804 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 699034003805 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 699034003806 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 699034003807 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 699034003808 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 699034003809 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 699034003810 Asp23 family; Region: Asp23; cl00574 699034003811 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 699034003812 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 699034003813 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 699034003814 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 699034003815 generic binding surface II; other site 699034003816 generic binding surface I; other site 699034003817 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 699034003818 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 699034003819 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 699034003820 substrate binding pocket [chemical binding]; other site 699034003821 chain length determination region; other site 699034003822 substrate-Mg2+ binding site; other site 699034003823 catalytic residues [active] 699034003824 aspartate-rich region 1; other site 699034003825 active site lid residues [active] 699034003826 aspartate-rich region 2; other site 699034003827 Divergent PAP2 family; Region: DUF212; cl00855 699034003828 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 699034003829 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 699034003830 TPP-binding site; other site 699034003831 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 699034003832 PYR/PP interface [polypeptide binding]; other site 699034003833 dimer interface [polypeptide binding]; other site 699034003834 TPP binding site [chemical binding]; other site 699034003835 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 699034003836 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 699034003837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 699034003838 RNA binding surface [nucleotide binding]; other site 699034003839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034003840 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 699034003841 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 699034003842 Walker A/P-loop; other site 699034003843 ATP binding site [chemical binding]; other site 699034003844 Q-loop/lid; other site 699034003845 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 699034003846 ABC transporter signature motif; other site 699034003847 Walker B; other site 699034003848 D-loop; other site 699034003849 H-loop/switch region; other site 699034003850 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034003851 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 699034003852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034003853 Coenzyme A binding pocket [chemical binding]; other site 699034003854 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 699034003855 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 699034003856 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 699034003857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034003858 active site 699034003859 phosphorylation site [posttranslational modification] 699034003860 intermolecular recognition site; other site 699034003861 dimerization interface [polypeptide binding]; other site 699034003862 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 699034003863 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 699034003864 Thiamine pyrophosphokinase; Region: TPK; cl08415 699034003865 active site 699034003866 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 699034003867 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 699034003868 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 699034003869 Ligand binding site; other site 699034003870 Putative Catalytic site; other site 699034003871 DXD motif; other site 699034003872 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 699034003873 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 699034003874 dimer interface [polypeptide binding]; other site 699034003875 active site 699034003876 ADP-ribose binding site [chemical binding]; other site 699034003877 nudix motif; other site 699034003878 metal binding site [ion binding]; metal-binding site 699034003879 Integral membrane protein DUF95; Region: DUF95; cl00572 699034003880 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034003881 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 699034003882 active site 699034003883 DNA binding site [nucleotide binding] 699034003884 Int/Topo IB signature motif; other site 699034003885 Sulfatase; Region: Sulfatase; cl10460 699034003886 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 699034003887 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 699034003888 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 699034003889 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 699034003890 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 699034003891 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 699034003892 YceG-like family; Region: YceG; pfam02618 699034003893 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 699034003894 dimerization interface [polypeptide binding]; other site 699034003895 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 699034003896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034003897 S-adenosylmethionine binding site [chemical binding]; other site 699034003898 putative protease; Provisional; Region: PRK15452 699034003899 Peptidase family U32; Region: Peptidase_U32; cl03113 699034003900 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 699034003901 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 699034003902 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034003903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034003904 DNA binding residues [nucleotide binding] 699034003905 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 699034003906 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 699034003907 catalytic residues [active] 699034003908 catalytic nucleophile [active] 699034003909 Recombinase; Region: Recombinase; pfam07508 699034003910 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 699034003911 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 699034003912 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 699034003913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 699034003914 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003915 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003916 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034003917 Helix-turn-helix domains; Region: HTH; cl00088 699034003918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 699034003919 Helix-turn-helix domains; Region: HTH; cl00088 699034003920 putative transposase OrfB; Reviewed; Region: PHA02517 699034003921 HTH-like domain; Region: HTH_21; pfam13276 699034003922 Integrase core domain; Region: rve; cl01316 699034003923 Integrase core domain; Region: rve_3; cl15866 699034003924 Helix-turn-helix domains; Region: HTH; cl00088 699034003925 VanZ like family; Region: VanZ; cl01971 699034003926 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034003927 elongation factor P; Validated; Region: PRK00529 699034003928 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 699034003929 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 699034003930 RNA binding site [nucleotide binding]; other site 699034003931 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 699034003932 RNA binding site [nucleotide binding]; other site 699034003933 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 699034003934 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 699034003935 dimerization interface [polypeptide binding]; other site 699034003936 active site 699034003937 metal binding site [ion binding]; metal-binding site 699034003938 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 699034003939 dsRNA binding site [nucleotide binding]; other site 699034003940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034003941 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 699034003942 FeS/SAM binding site; other site 699034003943 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 699034003944 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 699034003945 Walker A/P-loop; other site 699034003946 ATP binding site [chemical binding]; other site 699034003947 Q-loop/lid; other site 699034003948 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 699034003949 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 699034003950 ABC transporter signature motif; other site 699034003951 Walker B; other site 699034003952 D-loop; other site 699034003953 H-loop/switch region; other site 699034003954 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 699034003955 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 699034003956 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 699034003957 P loop; other site 699034003958 GTP binding site [chemical binding]; other site 699034003959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034003960 signal recognition particle protein; Provisional; Region: PRK10867 699034003961 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 699034003962 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 699034003963 P loop; other site 699034003964 GTP binding site [chemical binding]; other site 699034003965 Signal peptide binding domain; Region: SRP_SPB; pfam02978 699034003966 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 699034003967 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 699034003968 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 699034003969 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 699034003970 RimM N-terminal domain; Region: RimM; pfam01782 699034003971 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 699034003972 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 699034003973 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 699034003974 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 699034003975 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 699034003976 GTP/Mg2+ binding site [chemical binding]; other site 699034003977 G4 box; other site 699034003978 G5 box; other site 699034003979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034003980 G1 box; other site 699034003981 G1 box; other site 699034003982 GTP/Mg2+ binding site [chemical binding]; other site 699034003983 G2 box; other site 699034003984 Switch I region; other site 699034003985 Switch I region; other site 699034003986 G2 box; other site 699034003987 G3 box; other site 699034003988 G3 box; other site 699034003989 Switch II region; other site 699034003990 Switch II region; other site 699034003991 G4 box; other site 699034003992 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 699034003993 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 699034003994 ATP cone domain; Region: ATP-cone; pfam03477 699034003995 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 699034003996 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 699034003997 active site 699034003998 dimer interface [polypeptide binding]; other site 699034003999 effector binding site; other site 699034004000 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 699034004001 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 699034004002 RNA/DNA hybrid binding site [nucleotide binding]; other site 699034004003 active site 699034004004 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 699034004005 active site 699034004006 substrate binding site [chemical binding]; other site 699034004007 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 699034004008 FMN binding site [chemical binding]; other site 699034004009 putative catalytic residues [active] 699034004010 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 699034004011 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 699034004012 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 699034004013 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034004014 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034004015 Walker A/P-loop; other site 699034004016 ATP binding site [chemical binding]; other site 699034004017 Q-loop/lid; other site 699034004018 ABC transporter signature motif; other site 699034004019 Walker B; other site 699034004020 D-loop; other site 699034004021 H-loop/switch region; other site 699034004022 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 699034004023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034004024 active site 699034004025 phosphorylation site [posttranslational modification] 699034004026 intermolecular recognition site; other site 699034004027 dimerization interface [polypeptide binding]; other site 699034004028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 699034004029 DNA binding residues [nucleotide binding] 699034004030 dimerization interface [polypeptide binding]; other site 699034004031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 699034004032 Histidine kinase; Region: HisKA_3; pfam07730 699034004033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034004034 Restriction endonuclease; Region: Mrr_cat; cl00516 699034004035 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 699034004036 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 699034004037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034004038 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 699034004039 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 699034004040 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 699034004041 DNA topoisomerase I; Validated; Region: PRK05582 699034004042 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 699034004043 active site 699034004044 interdomain interaction site; other site 699034004045 putative metal-binding site [ion binding]; other site 699034004046 nucleotide binding site [chemical binding]; other site 699034004047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 699034004048 domain I; other site 699034004049 DNA binding groove [nucleotide binding] 699034004050 phosphate binding site [ion binding]; other site 699034004051 domain II; other site 699034004052 domain III; other site 699034004053 nucleotide binding site [chemical binding]; other site 699034004054 catalytic site [active] 699034004055 domain IV; other site 699034004056 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 699034004057 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 699034004058 CodY GAF-like domain; Region: CodY; pfam06018 699034004059 transcriptional repressor CodY; Validated; Region: PRK04158 699034004060 Helix-turn-helix domains; Region: HTH; cl00088 699034004061 recombination factor protein RarA; Reviewed; Region: PRK13342 699034004062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034004063 Walker A motif; other site 699034004064 ATP binding site [chemical binding]; other site 699034004065 Walker B motif; other site 699034004066 arginine finger; other site 699034004067 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 699034004068 Predicted acetyltransferase [General function prediction only]; Region: COG3393 699034004069 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034004070 Helix-turn-helix domains; Region: HTH; cl00088 699034004071 Rrf2 family protein; Region: rrf2_super; TIGR00738 699034004072 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 699034004073 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034004074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034004075 catalytic residue [active] 699034004076 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 699034004077 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 699034004078 trimerization site [polypeptide binding]; other site 699034004079 active site 699034004080 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 699034004081 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 699034004082 Ligand Binding Site [chemical binding]; other site 699034004083 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 699034004084 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 699034004085 motif 1; other site 699034004086 active site 699034004087 motif 2; other site 699034004088 motif 3; other site 699034004089 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 699034004090 DHHA1 domain; Region: DHHA1; pfam02272 699034004091 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 699034004092 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 699034004093 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 699034004094 ferric uptake regulator; Provisional; Region: fur; PRK09462 699034004095 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 699034004096 metal binding site 2 [ion binding]; metal-binding site 699034004097 putative DNA binding helix; other site 699034004098 metal binding site 1 [ion binding]; metal-binding site 699034004099 dimer interface [polypeptide binding]; other site 699034004100 structural Zn2+ binding site [ion binding]; other site 699034004101 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 699034004102 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 699034004103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034004104 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 699034004105 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 699034004106 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034004107 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 699034004108 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 699034004109 Cupin domain; Region: Cupin_2; cl09118 699034004110 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 699034004111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034004112 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 699034004113 active site 699034004114 putative substrate binding region [chemical binding]; other site 699034004115 ScpA/B protein; Region: ScpA_ScpB; cl00598 699034004116 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 699034004117 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 699034004118 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 699034004119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034004120 Helix-turn-helix domains; Region: HTH; cl00088 699034004121 potential frameshift: common BLAST hit: gi|260686505|ref|YP_003217638.1| leucyl aminopeptidase 699034004122 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 699034004123 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 699034004124 homodimer interface [polypeptide binding]; other site 699034004125 metal binding site [ion binding]; metal-binding site 699034004126 NAD-dependent deacetylase; Provisional; Region: PRK00481 699034004127 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 699034004128 Bacterial SH3 domain; Region: SH3_3; cl02551 699034004129 Bacterial SH3 domain; Region: SH3_3; cl02551 699034004130 Bacterial SH3 domain; Region: SH3_3; cl02551 699034004131 Bacterial SH3 domain; Region: SH3_3; cl02551 699034004132 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 699034004133 DNA polymerase III PolC; Validated; Region: polC; PRK00448 699034004134 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 699034004135 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 699034004136 generic binding surface II; other site 699034004137 generic binding surface I; other site 699034004138 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 699034004139 active site 699034004140 catalytic site [active] 699034004141 substrate binding site [chemical binding]; other site 699034004142 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 699034004143 ribosome maturation protein RimP; Reviewed; Region: PRK00092 699034004144 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 699034004145 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 699034004146 Sm1 motif; other site 699034004147 predicted subunit interaction site [polypeptide binding]; other site 699034004148 RNA binding pocket [nucleotide binding]; other site 699034004149 Sm2 motif; other site 699034004150 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 699034004151 NusA N-terminal domain; Region: NusA_N; pfam08529 699034004152 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 699034004153 RNA binding site [nucleotide binding]; other site 699034004154 homodimer interface [polypeptide binding]; other site 699034004155 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 699034004156 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 699034004157 G-X-X-G motif; other site 699034004158 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 699034004159 putative RNA binding cleft [nucleotide binding]; other site 699034004160 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 699034004161 translation initiation factor IF-2; Region: IF-2; TIGR00487 699034004162 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 699034004163 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 699034004164 G1 box; other site 699034004165 putative GEF interaction site [polypeptide binding]; other site 699034004166 GTP/Mg2+ binding site [chemical binding]; other site 699034004167 Switch I region; other site 699034004168 G2 box; other site 699034004169 G3 box; other site 699034004170 Switch II region; other site 699034004171 G4 box; other site 699034004172 G5 box; other site 699034004173 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 699034004174 Translation-initiation factor 2; Region: IF-2; pfam11987 699034004175 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 699034004176 Ribosome-binding factor A; Region: RBFA; cl00542 699034004177 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 699034004178 DHH family; Region: DHH; pfam01368 699034004179 DHHA1 domain; Region: DHHA1; pfam02272 699034004180 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 699034004181 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 699034004182 RNA binding site [nucleotide binding]; other site 699034004183 active site 699034004184 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 699034004185 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 699034004186 active site 699034004187 Riboflavin kinase; Region: Flavokinase; cl03312 699034004188 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 699034004189 16S/18S rRNA binding site [nucleotide binding]; other site 699034004190 S13e-L30e interaction site [polypeptide binding]; other site 699034004191 25S rRNA binding site [nucleotide binding]; other site 699034004192 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 699034004193 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 699034004194 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 699034004195 RNase E interface [polypeptide binding]; other site 699034004196 trimer interface [polypeptide binding]; other site 699034004197 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 699034004198 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 699034004199 RNase E interface [polypeptide binding]; other site 699034004200 trimer interface [polypeptide binding]; other site 699034004201 active site 699034004202 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 699034004203 putative nucleic acid binding region [nucleotide binding]; other site 699034004204 G-X-X-G motif; other site 699034004205 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 699034004206 RNA binding site [nucleotide binding]; other site 699034004207 domain interface; other site 699034004208 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 699034004209 NodB motif; other site 699034004210 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 699034004211 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 699034004212 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 699034004213 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 699034004214 aspartate kinase I; Reviewed; Region: PRK08210 699034004215 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 699034004216 putative catalytic residues [active] 699034004217 putative nucleotide binding site [chemical binding]; other site 699034004218 putative aspartate binding site [chemical binding]; other site 699034004219 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 699034004220 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 699034004221 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 699034004222 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 699034004223 active site 699034004224 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 699034004225 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 699034004226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034004227 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 699034004228 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 699034004229 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 699034004230 active site residue [active] 699034004231 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 699034004232 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 699034004233 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034004234 FeS/SAM binding site; other site 699034004235 TRAM domain; Region: TRAM; cl01282 699034004236 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 699034004237 recombinase A; Provisional; Region: recA; PRK09354 699034004238 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 699034004239 hexamer interface [polypeptide binding]; other site 699034004240 Walker A motif; other site 699034004241 ATP binding site [chemical binding]; other site 699034004242 Walker B motif; other site 699034004243 conserved hypothetical protein YmdA/YtgF; Region: YmdA_YtgF; TIGR03319 699034004244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 699034004245 Zn2+ binding site [ion binding]; other site 699034004246 Mg2+ binding site [ion binding]; other site 699034004247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034004248 ATP binding site [chemical binding]; other site 699034004249 putative Mg++ binding site [ion binding]; other site 699034004250 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 699034004251 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 699034004252 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 699034004253 Catalytic site [active] 699034004254 Bacitracin resistance protein BacA; Region: BacA; cl00858 699034004255 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034004256 active site 699034004257 Int/Topo IB signature motif; other site 699034004258 DNA binding site [nucleotide binding] 699034004259 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 699034004260 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 699034004261 tetramer interface [polypeptide binding]; other site 699034004262 active site 699034004263 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034004264 Helix-turn-helix domains; Region: HTH; cl00088 699034004265 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034004266 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 699034004267 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034004268 active site turn [active] 699034004269 phosphorylation site [posttranslational modification] 699034004270 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034004271 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034004272 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034004273 putative active site [active] 699034004274 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 699034004275 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 699034004276 NAD binding site [chemical binding]; other site 699034004277 sugar binding site [chemical binding]; other site 699034004278 divalent metal binding site [ion binding]; other site 699034004279 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034004280 dimer interface [polypeptide binding]; other site 699034004281 aspartate aminotransferase; Provisional; Region: PRK07568 699034004282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034004283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034004284 homodimer interface [polypeptide binding]; other site 699034004285 catalytic residue [active] 699034004286 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 699034004287 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 699034004288 nucleotide binding site/active site [active] 699034004289 HIT family signature motif; other site 699034004290 catalytic residue [active] 699034004291 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 699034004292 active site 699034004293 putative catalytic site [active] 699034004294 DNA binding site [nucleotide binding] 699034004295 putative phosphate binding site [ion binding]; other site 699034004296 metal binding site A [ion binding]; metal-binding site 699034004297 AP binding site [nucleotide binding]; other site 699034004298 metal binding site B [ion binding]; metal-binding site 699034004299 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 699034004300 active site 699034004301 catalytic site [active] 699034004302 substrate binding site [chemical binding]; other site 699034004303 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 699034004304 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 699034004305 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 699034004306 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 699034004307 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 699034004308 Helix-turn-helix domains; Region: HTH; cl00088 699034004309 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 699034004310 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 699034004311 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 699034004312 Walker A/P-loop; other site 699034004313 ATP binding site [chemical binding]; other site 699034004314 Q-loop/lid; other site 699034004315 ABC transporter signature motif; other site 699034004316 Walker B; other site 699034004317 D-loop; other site 699034004318 H-loop/switch region; other site 699034004319 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034004320 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034004321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034004322 dimer interface [polypeptide binding]; other site 699034004323 phosphorylation site [posttranslational modification] 699034004324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034004325 ATP binding site [chemical binding]; other site 699034004326 Mg2+ binding site [ion binding]; other site 699034004327 G-X-G motif; other site 699034004328 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 699034004329 dimer interface [polypeptide binding]; other site 699034004330 pyridoxal binding site [chemical binding]; other site 699034004331 ATP binding site [chemical binding]; other site 699034004332 NlpC/P60 family; Region: NLPC_P60; cl11438 699034004333 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 699034004334 DNA-binding site [nucleotide binding]; DNA binding site 699034004335 RNA-binding motif; other site 699034004336 FOG: CBS domain [General function prediction only]; Region: COG0517 699034004337 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 699034004338 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 699034004339 PPIC-type PPIASE domain; Region: Rotamase; cl08278 699034004340 Domain of unknown function (DUF955); Region: DUF955; cl01076 699034004341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004342 non-specific DNA binding site [nucleotide binding]; other site 699034004343 salt bridge; other site 699034004344 sequence-specific DNA binding site [nucleotide binding]; other site 699034004345 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 699034004346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004347 non-specific DNA binding site [nucleotide binding]; other site 699034004348 salt bridge; other site 699034004349 sequence-specific DNA binding site [nucleotide binding]; other site 699034004350 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 699034004351 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 699034004352 Phage XkdN-like protein; Region: XkdN; pfam08890 699034004353 NlpC/P60 family; Region: NLPC_P60; cl11438 699034004354 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 699034004355 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 699034004356 Baseplate J-like protein; Region: Baseplate_J; cl01294 699034004357 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 699034004358 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 699034004359 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004360 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 699034004361 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004362 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004363 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 699034004364 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004365 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 699034004366 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004367 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 699034004368 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004369 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 699034004370 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004371 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004372 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 699034004373 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 699034004374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 699034004375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004376 non-specific DNA binding site [nucleotide binding]; other site 699034004377 salt bridge; other site 699034004378 sequence-specific DNA binding site [nucleotide binding]; other site 699034004379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004380 non-specific DNA binding site [nucleotide binding]; other site 699034004381 salt bridge; other site 699034004382 sequence-specific DNA binding site [nucleotide binding]; other site 699034004383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004384 non-specific DNA binding site [nucleotide binding]; other site 699034004385 salt bridge; other site 699034004386 sequence-specific DNA binding site [nucleotide binding]; other site 699034004387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034004388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034004389 putative substrate translocation pore; other site 699034004390 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 699034004391 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 699034004392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034004393 Helix-turn-helix domains; Region: HTH; cl00088 699034004394 glycerol kinase; Provisional; Region: glpK; PRK00047 699034004395 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 699034004396 N- and C-terminal domain interface [polypeptide binding]; other site 699034004397 active site 699034004398 MgATP binding site [chemical binding]; other site 699034004399 catalytic site [active] 699034004400 metal binding site [ion binding]; metal-binding site 699034004401 glycerol binding site [chemical binding]; other site 699034004402 homotetramer interface [polypeptide binding]; other site 699034004403 homodimer interface [polypeptide binding]; other site 699034004404 FBP binding site [chemical binding]; other site 699034004405 protein IIAGlc interface [polypeptide binding]; other site 699034004406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034004407 DNA-binding site [nucleotide binding]; DNA binding site 699034004408 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 699034004409 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 699034004410 putative active site [active] 699034004411 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 699034004412 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 699034004413 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 699034004414 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 699034004415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004416 non-specific DNA binding site [nucleotide binding]; other site 699034004417 salt bridge; other site 699034004418 sequence-specific DNA binding site [nucleotide binding]; other site 699034004419 Cupin domain; Region: Cupin_2; cl09118 699034004420 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 699034004421 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 699034004422 active site 699034004423 Protein of unknown function (DUF819); Region: DUF819; cl02317 699034004424 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 699034004425 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 699034004426 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 699034004427 homotrimer interaction site [polypeptide binding]; other site 699034004428 putative active site [active] 699034004429 EamA-like transporter family; Region: EamA; cl01037 699034004430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034004431 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 699034004432 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_3; cd08770 699034004433 SxDxEG motif; other site 699034004434 putative active site [active] 699034004435 putative metal binding site [ion binding]; other site 699034004436 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 699034004437 homodimer interaction site [polypeptide binding]; other site 699034004438 cofactor binding site; other site 699034004439 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034004440 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 699034004441 metal binding site [ion binding]; metal-binding site 699034004442 dimer interface [polypeptide binding]; other site 699034004443 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 699034004444 dimer interface [polypeptide binding]; other site 699034004445 catalytic triad [active] 699034004446 Protein of unknown function (DUF3867); Region: DUF3867; pfam12983 699034004447 Isochorismatase family; Region: Isochorismatase; pfam00857 699034004448 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 699034004449 catalytic triad [active] 699034004450 conserved cis-peptide bond; other site 699034004451 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 699034004452 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 699034004453 active site 699034004454 catalytic site [active] 699034004455 metal binding site [ion binding]; metal-binding site 699034004456 dimer interface [polypeptide binding]; other site 699034004457 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 699034004458 AMP-binding enzyme; Region: AMP-binding; cl15778 699034004459 acyl-CoA synthetase; Validated; Region: PRK08308 699034004460 OPT oligopeptide transporter protein; Region: OPT; cl14607 699034004461 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 699034004462 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 699034004463 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 699034004464 Walker A/P-loop; other site 699034004465 ATP binding site [chemical binding]; other site 699034004466 Q-loop/lid; other site 699034004467 ABC transporter signature motif; other site 699034004468 Walker B; other site 699034004469 D-loop; other site 699034004470 H-loop/switch region; other site 699034004471 ABC transporter; Region: ABC_tran_2; pfam12848 699034004472 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034004473 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 699034004474 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 699034004475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034004476 DNA-binding site [nucleotide binding]; DNA binding site 699034004477 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034004478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034004479 homodimer interface [polypeptide binding]; other site 699034004480 catalytic residue [active] 699034004481 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 699034004482 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 699034004483 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034004484 competence damage-inducible protein A; Provisional; Region: PRK00549 699034004485 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 699034004486 putative MPT binding site; other site 699034004487 Competence-damaged protein; Region: CinA; cl00666 699034004488 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 699034004489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034004490 active site 699034004491 motif I; other site 699034004492 motif II; other site 699034004493 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034004494 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034004495 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 699034004496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034004497 PAS domain; Region: PAS_9; pfam13426 699034004498 putative active site [active] 699034004499 heme pocket [chemical binding]; other site 699034004500 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 699034004501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034004502 Walker A motif; other site 699034004503 ATP binding site [chemical binding]; other site 699034004504 Walker B motif; other site 699034004505 arginine finger; other site 699034004506 EamA-like transporter family; Region: EamA; cl01037 699034004507 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 699034004508 EamA-like transporter family; Region: EamA; cl01037 699034004509 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 699034004510 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 699034004511 Protein of unknown function, DUF606; Region: DUF606; cl01273 699034004512 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 699034004513 Ligand Binding Site [chemical binding]; other site 699034004514 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 699034004515 MatE; Region: MatE; cl10513 699034004516 MatE; Region: MatE; cl10513 699034004517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034004518 Integrase core domain; Region: rve; cl01316 699034004519 Integrase core domain; Region: rve_3; cl15866 699034004520 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 699034004521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034004522 PAS fold; Region: PAS_3; pfam08447 699034004523 putative active site [active] 699034004524 heme pocket [chemical binding]; other site 699034004525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034004526 metal binding site [ion binding]; metal-binding site 699034004527 active site 699034004528 I-site; other site 699034004529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034004530 metal binding site [ion binding]; metal-binding site 699034004531 active site 699034004532 I-site; other site 699034004533 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034004534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034004535 putative active site [active] 699034004536 heme pocket [chemical binding]; other site 699034004537 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 699034004538 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 699034004539 DNA binding residues [nucleotide binding] 699034004540 dimer interface [polypeptide binding]; other site 699034004541 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034004542 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 699034004543 MgtC family; Region: MgtC; pfam02308 699034004544 Isochorismatase family; Region: Isochorismatase; pfam00857 699034004545 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 699034004546 catalytic triad [active] 699034004547 conserved cis-peptide bond; other site 699034004548 Helix-turn-helix domains; Region: HTH; cl00088 699034004549 Predicted acetyltransferase [General function prediction only]; Region: COG3393 699034004550 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034004551 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034004552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034004553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034004554 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 699034004555 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 699034004556 NodB motif; other site 699034004557 active site 699034004558 catalytic site [active] 699034004559 Cd binding site [ion binding]; other site 699034004560 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 699034004561 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 699034004562 active site 699034004563 catalytic site [active] 699034004564 substrate binding site [chemical binding]; other site 699034004565 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 699034004566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034004567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034004568 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 699034004569 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 699034004570 RNA/DNA hybrid binding site [nucleotide binding]; other site 699034004571 active site 699034004572 peroxiredoxin; Provisional; Region: PRK13189 699034004573 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 699034004574 dimer interface [polypeptide binding]; other site 699034004575 decamer (pentamer of dimers) interface [polypeptide binding]; other site 699034004576 catalytic triad [active] 699034004577 Glyco_18 domain; Region: Glyco_18; smart00636 699034004578 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 699034004579 active site 699034004580 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 699034004581 VanW like protein; Region: VanW; pfam04294 699034004582 G5 domain; Region: G5; pfam07501 699034004583 Helix-turn-helix domains; Region: HTH; cl00088 699034004584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 699034004585 LrgA family; Region: LrgA; cl00608 699034004586 LrgB-like family; Region: LrgB; cl00596 699034004587 Uncharacterized conserved protein [Function unknown]; Region: COG1284 699034004588 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034004589 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 699034004590 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 699034004591 MORN repeat; Region: MORN; cl14787 699034004592 MORN repeat; Region: MORN; cl14787 699034004593 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 699034004594 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 699034004595 NodB motif; other site 699034004596 active site 699034004597 catalytic site [active] 699034004598 metal binding site [ion binding]; metal-binding site 699034004599 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 699034004600 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 699034004601 glutamine binding [chemical binding]; other site 699034004602 catalytic triad [active] 699034004603 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 699034004604 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 699034004605 chorismate binding enzyme; Region: Chorismate_bind; cl10555 699034004606 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 699034004607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034004608 catalytic residue [active] 699034004609 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 699034004610 homodecamer interface [polypeptide binding]; other site 699034004611 GTP cyclohydrolase I; Provisional; Region: PLN03044 699034004612 active site 699034004613 putative catalytic site residues [active] 699034004614 zinc binding site [ion binding]; other site 699034004615 GTP-CH-I/GFRP interaction surface; other site 699034004616 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 699034004617 dihydropteroate synthase; Region: DHPS; TIGR01496 699034004618 substrate binding pocket [chemical binding]; other site 699034004619 dimer interface [polypeptide binding]; other site 699034004620 inhibitor binding site; inhibition site 699034004621 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 699034004622 homooctamer interface [polypeptide binding]; other site 699034004623 active site 699034004624 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 699034004625 catalytic center binding site [active] 699034004626 ATP binding site [chemical binding]; other site 699034004627 NeuB family; Region: NeuB; cl00496 699034004628 DNA primase; Validated; Region: dnaG; PRK05667 699034004629 CHC2 zinc finger; Region: zf-CHC2; cl15369 699034004630 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 699034004631 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 699034004632 active site 699034004633 metal binding site [ion binding]; metal-binding site 699034004634 interdomain interaction site; other site 699034004635 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 699034004636 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 699034004637 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 699034004638 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 699034004639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034004640 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 699034004641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034004642 DNA binding residues [nucleotide binding] 699034004643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034004644 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 699034004645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 699034004646 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 699034004647 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034004648 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 699034004649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034004650 Predicted membrane protein [General function prediction only]; Region: COG4194 699034004651 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 699034004652 Predicted transcriptional regulators [Transcription]; Region: COG1725 699034004653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034004654 DNA-binding site [nucleotide binding]; DNA binding site 699034004655 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034004656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034004657 active site 699034004658 phosphorylation site [posttranslational modification] 699034004659 intermolecular recognition site; other site 699034004660 dimerization interface [polypeptide binding]; other site 699034004661 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034004662 DNA binding site [nucleotide binding] 699034004663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034004664 dimer interface [polypeptide binding]; other site 699034004665 phosphorylation site [posttranslational modification] 699034004666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034004667 ATP binding site [chemical binding]; other site 699034004668 Mg2+ binding site [ion binding]; other site 699034004669 G-X-G motif; other site 699034004670 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034004671 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034004672 Walker A/P-loop; other site 699034004673 ATP binding site [chemical binding]; other site 699034004674 Q-loop/lid; other site 699034004675 ABC transporter signature motif; other site 699034004676 Walker B; other site 699034004677 D-loop; other site 699034004678 H-loop/switch region; other site 699034004679 Helix-turn-helix domains; Region: HTH; cl00088 699034004680 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 699034004681 4Fe-4S binding domain; Region: Fer4; cl02805 699034004682 ferredoxin; Validated; Region: PRK07118 699034004683 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 699034004684 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034004685 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034004686 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034004687 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034004688 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 699034004689 active site residue [active] 699034004690 potential frameshift: common BLAST hit: gi|260686685|ref|YP_003217818.1| membrane protein ( phage infection protein) 699034004691 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034004692 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034004693 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034004694 Walker A/P-loop; other site 699034004695 ATP binding site [chemical binding]; other site 699034004696 Q-loop/lid; other site 699034004697 ABC transporter signature motif; other site 699034004698 Walker B; other site 699034004699 D-loop; other site 699034004700 H-loop/switch region; other site 699034004701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034004702 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034004703 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 699034004704 Walker A/P-loop; other site 699034004705 ATP binding site [chemical binding]; other site 699034004706 Q-loop/lid; other site 699034004707 ABC transporter signature motif; other site 699034004708 Walker B; other site 699034004709 D-loop; other site 699034004710 H-loop/switch region; other site 699034004711 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 699034004712 Rubredoxin; Region: Rubredoxin; pfam00301 699034004713 iron binding site [ion binding]; other site 699034004714 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 699034004715 diiron binding motif [ion binding]; other site 699034004716 CAAX protease self-immunity; Region: Abi; cl00558 699034004717 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 699034004718 FeoA domain; Region: FeoA; cl00838 699034004719 FeoA domain; Region: FeoA; cl00838 699034004720 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 699034004721 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 699034004722 G1 box; other site 699034004723 GTP/Mg2+ binding site [chemical binding]; other site 699034004724 Switch I region; other site 699034004725 G2 box; other site 699034004726 G3 box; other site 699034004727 Switch II region; other site 699034004728 G4 box; other site 699034004729 G5 box; other site 699034004730 Nucleoside recognition; Region: Gate; cl00486 699034004731 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 699034004732 Nucleoside recognition; Region: Gate; cl00486 699034004733 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 699034004734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034004735 dimer interface [polypeptide binding]; other site 699034004736 conserved gate region; other site 699034004737 putative PBP binding loops; other site 699034004738 ABC-ATPase subunit interface; other site 699034004739 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 699034004740 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 699034004741 Walker A/P-loop; other site 699034004742 ATP binding site [chemical binding]; other site 699034004743 Q-loop/lid; other site 699034004744 ABC transporter signature motif; other site 699034004745 Walker B; other site 699034004746 D-loop; other site 699034004747 H-loop/switch region; other site 699034004748 NMT1-like family; Region: NMT1_2; cl15260 699034004749 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 699034004750 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 699034004751 Predicted transcriptional regulator [Transcription]; Region: COG2378 699034004752 Helix-turn-helix domains; Region: HTH; cl00088 699034004753 WYL domain; Region: WYL; cl14852 699034004754 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034004755 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034004756 Probable transposase; Region: OrfB_IS605; pfam01385 699034004757 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034004758 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 699034004759 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 699034004760 Walker A/P-loop; other site 699034004761 ATP binding site [chemical binding]; other site 699034004762 Q-loop/lid; other site 699034004763 ABC transporter signature motif; other site 699034004764 Walker B; other site 699034004765 D-loop; other site 699034004766 H-loop/switch region; other site 699034004767 NIL domain; Region: NIL; cl09633 699034004768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034004769 dimer interface [polypeptide binding]; other site 699034004770 conserved gate region; other site 699034004771 ABC-ATPase subunit interface; other site 699034004772 NMT1-like family; Region: NMT1_2; cl15260 699034004773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034004774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034004775 dimer interface [polypeptide binding]; other site 699034004776 phosphorylation site [posttranslational modification] 699034004777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034004778 ATP binding site [chemical binding]; other site 699034004779 Mg2+ binding site [ion binding]; other site 699034004780 G-X-G motif; other site 699034004781 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 699034004782 active site 699034004783 DNA binding site [nucleotide binding] 699034004784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034004785 non-specific DNA binding site [nucleotide binding]; other site 699034004786 salt bridge; other site 699034004787 sequence-specific DNA binding site [nucleotide binding]; other site 699034004788 Cupin domain; Region: Cupin_2; cl09118 699034004789 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 699034004790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034004791 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 699034004792 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 699034004793 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 699034004794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034004795 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 699034004796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034004797 DNA binding residues [nucleotide binding] 699034004798 integral membrane protein MviN; Region: mviN; TIGR01695 699034004799 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 699034004800 intersubunit interface [polypeptide binding]; other site 699034004801 active site 699034004802 catalytic residue [active] 699034004803 Predicted transcriptional regulators [Transcription]; Region: COG1725 699034004804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034004805 DNA-binding site [nucleotide binding]; DNA binding site 699034004806 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034004807 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034004808 Walker A/P-loop; other site 699034004809 ATP binding site [chemical binding]; other site 699034004810 Q-loop/lid; other site 699034004811 ABC transporter signature motif; other site 699034004812 Walker B; other site 699034004813 D-loop; other site 699034004814 H-loop/switch region; other site 699034004815 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 699034004816 MatE; Region: MatE; cl10513 699034004817 MatE; Region: MatE; cl10513 699034004818 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 699034004819 catalytic residues [active] 699034004820 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 699034004821 4Fe-4S binding domain; Region: Fer4_5; pfam12801 699034004822 4Fe-4S binding domain; Region: Fer4; cl02805 699034004823 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 699034004824 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 699034004825 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 699034004826 pantoate--beta-alanine ligase; Region: panC; TIGR00018 699034004827 Pantoate-beta-alanine ligase; Region: PanC; cd00560 699034004828 active site 699034004829 ATP-binding site [chemical binding]; other site 699034004830 pantoate-binding site; other site 699034004831 HXXH motif; other site 699034004832 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 699034004833 oligomerization interface [polypeptide binding]; other site 699034004834 active site 699034004835 metal binding site [ion binding]; metal-binding site 699034004836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034004837 PAS fold; Region: PAS_3; pfam08447 699034004838 putative active site [active] 699034004839 heme pocket [chemical binding]; other site 699034004840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034004841 metal binding site [ion binding]; metal-binding site 699034004842 active site 699034004843 I-site; other site 699034004844 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034004845 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 699034004846 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034004847 DNA binding residues [nucleotide binding] 699034004848 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034004849 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 699034004850 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 699034004851 G1 box; other site 699034004852 GTP/Mg2+ binding site [chemical binding]; other site 699034004853 Switch I region; other site 699034004854 G2 box; other site 699034004855 G3 box; other site 699034004856 Switch II region; other site 699034004857 G4 box; other site 699034004858 G5 box; other site 699034004859 Nucleoside recognition; Region: Gate; cl00486 699034004860 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 699034004861 Nucleoside recognition; Region: Gate; cl00486 699034004862 FeoA domain; Region: FeoA; cl00838 699034004863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 699034004864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034004865 Coenzyme A binding pocket [chemical binding]; other site 699034004866 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 699034004867 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 699034004868 active site 699034004869 HIGH motif; other site 699034004870 dimer interface [polypeptide binding]; other site 699034004871 KMSKS motif; other site 699034004872 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 699034004873 RNA binding surface [nucleotide binding]; other site 699034004874 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 699034004875 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 699034004876 NodB motif; other site 699034004877 active site 699034004878 catalytic site [active] 699034004879 Zn binding site [ion binding]; other site 699034004880 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 699034004881 EamA-like transporter family; Region: EamA; cl01037 699034004882 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 699034004883 Rubredoxin; Region: Rubredoxin; pfam00301 699034004884 iron binding site [ion binding]; other site 699034004885 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 699034004886 diiron binding motif [ion binding]; other site 699034004887 Uncharacterized conserved protein [Function unknown]; Region: COG2006 699034004888 Domain of unknown function (DUF362); Region: DUF362; pfam04015 699034004889 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 699034004890 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 699034004891 dihydroorotase; Validated; Region: pyrC; PRK09357 699034004892 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034004893 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 699034004894 active site 699034004895 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034004896 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 699034004897 FtsX-like permease family; Region: FtsX; cl15850 699034004898 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034004899 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034004900 Walker A/P-loop; other site 699034004901 ATP binding site [chemical binding]; other site 699034004902 Q-loop/lid; other site 699034004903 ABC transporter signature motif; other site 699034004904 Walker B; other site 699034004905 D-loop; other site 699034004906 H-loop/switch region; other site 699034004907 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 699034004908 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 699034004909 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 699034004910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034004911 ATP binding site [chemical binding]; other site 699034004912 Mg2+ binding site [ion binding]; other site 699034004913 G-X-G motif; other site 699034004914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034004915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034004916 active site 699034004917 phosphorylation site [posttranslational modification] 699034004918 intermolecular recognition site; other site 699034004919 dimerization interface [polypeptide binding]; other site 699034004920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034004921 DNA binding site [nucleotide binding] 699034004922 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034004923 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034004924 Walker A/P-loop; other site 699034004925 ATP binding site [chemical binding]; other site 699034004926 Q-loop/lid; other site 699034004927 ABC transporter signature motif; other site 699034004928 Walker B; other site 699034004929 D-loop; other site 699034004930 H-loop/switch region; other site 699034004931 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 699034004932 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 699034004933 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 699034004934 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 699034004935 active site residue [active] 699034004936 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 699034004937 active site residue [active] 699034004938 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 699034004939 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 699034004940 FAD binding pocket [chemical binding]; other site 699034004941 FAD binding motif [chemical binding]; other site 699034004942 phosphate binding motif [ion binding]; other site 699034004943 beta-alpha-beta structure motif; other site 699034004944 NAD binding pocket [chemical binding]; other site 699034004945 Iron coordination center [ion binding]; other site 699034004946 putative oxidoreductase; Provisional; Region: PRK12831 699034004947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034004948 Cache domain; Region: Cache_1; pfam02743 699034004949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034004950 metal binding site [ion binding]; metal-binding site 699034004951 active site 699034004952 I-site; other site 699034004953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034004954 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034004955 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034004956 Walker A/P-loop; other site 699034004957 ATP binding site [chemical binding]; other site 699034004958 Q-loop/lid; other site 699034004959 ABC transporter signature motif; other site 699034004960 Walker B; other site 699034004961 D-loop; other site 699034004962 H-loop/switch region; other site 699034004963 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 699034004964 MatE; Region: MatE; cl10513 699034004965 MatE; Region: MatE; cl10513 699034004966 Fic family protein [Function unknown]; Region: COG3177 699034004967 Fic/DOC family; Region: Fic; cl00960 699034004968 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034004969 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 699034004970 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 699034004971 Haemolysin-III related; Region: HlyIII; cl03831 699034004972 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 699034004973 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 699034004974 dimer interface [polypeptide binding]; other site 699034004975 motif 1; other site 699034004976 active site 699034004977 motif 2; other site 699034004978 motif 3; other site 699034004979 ATP phosphoribosyltransferase; Region: HisG; cl15266 699034004980 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 699034004981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034004982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034004983 homodimer interface [polypeptide binding]; other site 699034004984 catalytic residue [active] 699034004985 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 699034004986 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 699034004987 putative active site pocket [active] 699034004988 4-fold oligomerization interface [polypeptide binding]; other site 699034004989 metal binding residues [ion binding]; metal-binding site 699034004990 3-fold/trimer interface [polypeptide binding]; other site 699034004991 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 699034004992 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 699034004993 putative active site [active] 699034004994 oxyanion strand; other site 699034004995 catalytic triad [active] 699034004996 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 699034004997 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 699034004998 catalytic residues [active] 699034004999 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 699034005000 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 699034005001 substrate binding site [chemical binding]; other site 699034005002 glutamase interaction surface [polypeptide binding]; other site 699034005003 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 699034005004 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 699034005005 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 699034005006 metal binding site [ion binding]; metal-binding site 699034005007 L-type amino acid transporter; Region: 2A0308; TIGR00911 699034005008 Spore germination protein; Region: Spore_permease; cl15802 699034005009 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 699034005010 NodB motif; other site 699034005011 active site 699034005012 catalytic site [active] 699034005013 Zn binding site [ion binding]; other site 699034005014 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 699034005015 PPIC-type PPIASE domain; Region: Rotamase; cl08278 699034005016 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 699034005017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034005018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034005019 DNA binding residues [nucleotide binding] 699034005020 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 699034005021 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 699034005022 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 699034005023 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 699034005024 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 699034005025 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 699034005026 XdhC Rossmann domain; Region: XdhC_C; pfam13478 699034005027 Protein of unknown function DUF45; Region: DUF45; cl00636 699034005028 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 699034005029 ketol-acid reductoisomerase; Provisional; Region: PRK05479 699034005030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034005031 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 699034005032 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 699034005033 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 699034005034 PYR/PP interface [polypeptide binding]; other site 699034005035 dimer interface [polypeptide binding]; other site 699034005036 TPP binding site [chemical binding]; other site 699034005037 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 699034005038 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 699034005039 TPP-binding site [chemical binding]; other site 699034005040 dimer interface [polypeptide binding]; other site 699034005041 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 699034005042 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 699034005043 Int/Topo IB signature motif; other site 699034005044 HIRAN domain; Region: HIRAN; cl07418 699034005045 C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973 699034005046 HipA-like C-terminal domain; Region: HipA_C; pfam07804 699034005047 putative catalytic residues [active] 699034005048 putative catalytic loop [active] 699034005049 Domain of unknown function (DUF955); Region: DUF955; cl01076 699034005050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005051 non-specific DNA binding site [nucleotide binding]; other site 699034005052 salt bridge; other site 699034005053 sequence-specific DNA binding site [nucleotide binding]; other site 699034005054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005055 sequence-specific DNA binding site [nucleotide binding]; other site 699034005056 salt bridge; other site 699034005057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005058 non-specific DNA binding site [nucleotide binding]; other site 699034005059 salt bridge; other site 699034005060 sequence-specific DNA binding site [nucleotide binding]; other site 699034005061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005062 non-specific DNA binding site [nucleotide binding]; other site 699034005063 salt bridge; other site 699034005064 sequence-specific DNA binding site [nucleotide binding]; other site 699034005065 BRO family, N-terminal domain; Region: Bro-N; cl10591 699034005066 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 699034005067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005068 non-specific DNA binding site [nucleotide binding]; other site 699034005069 salt bridge; other site 699034005070 sequence-specific DNA binding site [nucleotide binding]; other site 699034005071 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 699034005072 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 699034005073 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 699034005074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034005075 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 699034005076 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 699034005077 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 699034005078 active site 699034005079 DNA binding site [nucleotide binding] 699034005080 catalytic site [active] 699034005081 Virulence-associated protein E; Region: VirE; pfam05272 699034005082 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 699034005083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034005084 ATP binding site [chemical binding]; other site 699034005085 putative Mg++ binding site [ion binding]; other site 699034005086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034005087 nucleotide binding region [chemical binding]; other site 699034005088 ATP-binding site [chemical binding]; other site 699034005089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034005090 BRO family, N-terminal domain; Region: Bro-N; cl10591 699034005091 Uncharacterized conserved protein [Function unknown]; Region: COG5484 699034005092 Helix-turn-helix domains; Region: HTH; cl00088 699034005093 Phage terminase large subunit; Region: Terminase_3; cl12054 699034005094 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 699034005095 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 699034005096 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 699034005097 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 699034005098 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 699034005099 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 699034005100 Phage XkdN-like protein; Region: XkdN; pfam08890 699034005101 BRO family, N-terminal domain; Region: Bro-N; cl10591 699034005102 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 699034005103 Short C-terminal domain; Region: SHOCT; cl01373 699034005104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 699034005105 NlpC/P60 family; Region: NLPC_P60; cl11438 699034005106 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 699034005107 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 699034005108 Baseplate J-like protein; Region: Baseplate_J; cl01294 699034005109 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 699034005110 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 699034005111 Viral coat protein; Region: Flexi_CP; pfam00286 699034005112 Abi-like protein; Region: Abi_2; cl01988 699034005113 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034005114 active site 699034005115 metal binding site [ion binding]; metal-binding site 699034005116 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 699034005117 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005118 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005119 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005120 Uncharacterized conserved protein [Function unknown]; Region: COG1633 699034005121 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 699034005122 dimanganese center [ion binding]; other site 699034005123 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 699034005124 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 699034005125 catalytic residues [active] 699034005126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034005127 Helix-turn-helix domains; Region: HTH; cl00088 699034005128 Helix-turn-helix domains; Region: HTH; cl00088 699034005129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034005130 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 699034005131 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034005132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034005133 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034005134 Probable transposase; Region: OrfB_IS605; pfam01385 699034005135 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034005136 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 699034005137 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 699034005138 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 699034005139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005140 non-specific DNA binding site [nucleotide binding]; other site 699034005141 salt bridge; other site 699034005142 sequence-specific DNA binding site [nucleotide binding]; other site 699034005143 Tetratricopeptide repeat; Region: TPR_12; pfam13424 699034005144 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034005145 Domain of unknown function (DUF348); Region: DUF348; pfam03990 699034005146 G5 domain; Region: G5; pfam07501 699034005147 3D domain; Region: 3D; cl01439 699034005148 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 699034005149 active site 699034005150 catalytic triad [active] 699034005151 oxyanion hole [active] 699034005152 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 699034005153 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 699034005154 active site 699034005155 substrate binding site [chemical binding]; other site 699034005156 metal binding site [ion binding]; metal-binding site 699034005157 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 699034005158 sensory histidine kinase AtoS; Provisional; Region: PRK11360 699034005159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005160 dimer interface [polypeptide binding]; other site 699034005161 phosphorylation site [posttranslational modification] 699034005162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034005163 ATP binding site [chemical binding]; other site 699034005164 Mg2+ binding site [ion binding]; other site 699034005165 G-X-G motif; other site 699034005166 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 699034005167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034005168 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 699034005169 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 699034005170 histidinol dehydrogenase; Region: hisD; TIGR00069 699034005171 NAD binding site [chemical binding]; other site 699034005172 dimerization interface [polypeptide binding]; other site 699034005173 product binding site; other site 699034005174 substrate binding site [chemical binding]; other site 699034005175 zinc binding site [ion binding]; other site 699034005176 catalytic residues [active] 699034005177 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034005178 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 699034005179 Mor transcription activator family; Region: Mor; cl02360 699034005180 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034005181 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 699034005182 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034005183 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 699034005184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034005185 Walker A/P-loop; other site 699034005186 ATP binding site [chemical binding]; other site 699034005187 Q-loop/lid; other site 699034005188 ABC transporter signature motif; other site 699034005189 Walker B; other site 699034005190 D-loop; other site 699034005191 H-loop/switch region; other site 699034005192 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 699034005193 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 699034005194 TM-ABC transporter signature motif; other site 699034005195 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 699034005196 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 699034005197 ligand binding site [chemical binding]; other site 699034005198 Uncharacterized conserved protein [Function unknown]; Region: COG1284 699034005199 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 699034005200 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 699034005201 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034005202 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034005203 K+-transporting ATPase, c chain; Region: KdpC; cl00944 699034005204 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 699034005205 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 699034005206 dimer interface [polypeptide binding]; other site 699034005207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034005208 catalytic residue [active] 699034005209 serine O-acetyltransferase; Region: cysE; TIGR01172 699034005210 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 699034005211 trimer interface [polypeptide binding]; other site 699034005212 active site 699034005213 substrate binding site [chemical binding]; other site 699034005214 CoA binding site [chemical binding]; other site 699034005215 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 699034005216 methionine aminopeptidase; Provisional; Region: PRK12318 699034005217 SEC-C motif; Region: SEC-C; pfam02810 699034005218 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 699034005219 active site 699034005220 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 699034005221 GIY-YIG motif/motif A; other site 699034005222 putative active site [active] 699034005223 putative metal binding site [ion binding]; other site 699034005224 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 699034005225 dimer interface [polypeptide binding]; other site 699034005226 substrate binding site [chemical binding]; other site 699034005227 ATP binding site [chemical binding]; other site 699034005228 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 699034005229 substrate binding site [chemical binding]; other site 699034005230 multimerization interface [polypeptide binding]; other site 699034005231 ATP binding site [chemical binding]; other site 699034005232 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 699034005233 thiamine phosphate binding site [chemical binding]; other site 699034005234 active site 699034005235 pyrophosphate binding site [ion binding]; other site 699034005236 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034005237 active site 699034005238 P-loop; other site 699034005239 phosphorylation site [posttranslational modification] 699034005240 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034005241 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034005242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034005243 Walker A/P-loop; other site 699034005244 ATP binding site [chemical binding]; other site 699034005245 Q-loop/lid; other site 699034005246 ABC transporter signature motif; other site 699034005247 Walker B; other site 699034005248 D-loop; other site 699034005249 H-loop/switch region; other site 699034005250 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034005251 Predicted transcriptional regulators [Transcription]; Region: COG1725 699034005252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034005253 DNA-binding site [nucleotide binding]; DNA binding site 699034005254 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 699034005255 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034005256 Walker A/P-loop; other site 699034005257 ATP binding site [chemical binding]; other site 699034005258 Q-loop/lid; other site 699034005259 ABC transporter signature motif; other site 699034005260 Walker B; other site 699034005261 D-loop; other site 699034005262 H-loop/switch region; other site 699034005263 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 699034005264 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034005265 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 699034005266 active site 699034005267 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 699034005268 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034005269 Walker A/P-loop; other site 699034005270 ATP binding site [chemical binding]; other site 699034005271 Q-loop/lid; other site 699034005272 ABC transporter signature motif; other site 699034005273 Walker B; other site 699034005274 D-loop; other site 699034005275 H-loop/switch region; other site 699034005276 ABC-2 type transporter; Region: ABC2_membrane; cl11417 699034005277 CAAX protease self-immunity; Region: Abi; cl00558 699034005278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034005279 metal binding site [ion binding]; metal-binding site 699034005280 active site 699034005281 I-site; other site 699034005282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034005283 Predicted transcriptional regulators [Transcription]; Region: COG1725 699034005284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034005285 DNA-binding site [nucleotide binding]; DNA binding site 699034005286 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 699034005287 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034005288 Walker A/P-loop; other site 699034005289 ATP binding site [chemical binding]; other site 699034005290 Q-loop/lid; other site 699034005291 ABC transporter signature motif; other site 699034005292 Walker B; other site 699034005293 D-loop; other site 699034005294 H-loop/switch region; other site 699034005295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034005296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034005297 putative substrate translocation pore; other site 699034005298 Mechanosensitive ion channel; Region: MS_channel; pfam00924 699034005299 Predicted membrane protein [Function unknown]; Region: COG3212 699034005300 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 699034005301 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 699034005302 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 699034005303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034005304 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034005305 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 699034005306 iron binding site [ion binding]; other site 699034005307 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 699034005308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034005309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034005310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034005311 active site 699034005312 phosphorylation site [posttranslational modification] 699034005313 intermolecular recognition site; other site 699034005314 dimerization interface [polypeptide binding]; other site 699034005315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034005316 DNA binding site [nucleotide binding] 699034005317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034005318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005319 dimer interface [polypeptide binding]; other site 699034005320 phosphorylation site [posttranslational modification] 699034005321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034005322 ATP binding site [chemical binding]; other site 699034005323 Mg2+ binding site [ion binding]; other site 699034005324 G-X-G motif; other site 699034005325 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 699034005326 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 699034005327 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034005328 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 699034005329 Acyltransferase family; Region: Acyl_transf_3; pfam01757 699034005330 OpgC protein; Region: OpgC_C; cl00792 699034005331 alanine racemase; Reviewed; Region: alr; PRK00053 699034005332 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, VanT and similar proteins; Region: PLPDE_III_VanT; cd06825 699034005333 active site 699034005334 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034005335 dimer interface [polypeptide binding]; other site 699034005336 substrate binding site [chemical binding]; other site 699034005337 catalytic residues [active] 699034005338 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 699034005339 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 699034005340 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 699034005341 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 699034005342 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 699034005343 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 699034005344 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 699034005345 active site 699034005346 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 699034005347 Ligand Binding Site [chemical binding]; other site 699034005348 Molecular Tunnel; other site 699034005349 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 699034005350 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 699034005351 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 699034005352 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 699034005353 putative metal binding site [ion binding]; other site 699034005354 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 699034005355 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 699034005356 putative metal binding site [ion binding]; other site 699034005357 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 699034005358 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 699034005359 putative metal binding site [ion binding]; other site 699034005360 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 699034005361 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 699034005362 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034005363 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 699034005364 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034005365 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 699034005366 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 699034005367 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 699034005368 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 699034005369 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034005370 active site 699034005371 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 699034005372 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 699034005373 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 699034005374 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 699034005375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005376 non-specific DNA binding site [nucleotide binding]; other site 699034005377 salt bridge; other site 699034005378 sequence-specific DNA binding site [nucleotide binding]; other site 699034005379 Cupin domain; Region: Cupin_2; cl09118 699034005380 Protein of unknown function (DUF819); Region: DUF819; cl02317 699034005381 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 699034005382 active site 699034005383 dimer interface [polypeptide binding]; other site 699034005384 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 699034005385 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 699034005386 ABC-ATPase subunit interface; other site 699034005387 dimer interface [polypeptide binding]; other site 699034005388 putative PBP binding regions; other site 699034005389 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 699034005390 ABC-ATPase subunit interface; other site 699034005391 dimer interface [polypeptide binding]; other site 699034005392 putative PBP binding regions; other site 699034005393 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 699034005394 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 699034005395 Walker A/P-loop; other site 699034005396 ATP binding site [chemical binding]; other site 699034005397 Q-loop/lid; other site 699034005398 ABC transporter signature motif; other site 699034005399 Walker B; other site 699034005400 D-loop; other site 699034005401 H-loop/switch region; other site 699034005402 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 699034005403 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 699034005404 putative ligand binding residues [chemical binding]; other site 699034005405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034005406 metal binding site [ion binding]; metal-binding site 699034005407 active site 699034005408 I-site; other site 699034005409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034005410 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 699034005411 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 699034005412 putative metal binding site [ion binding]; other site 699034005413 NMT1-like family; Region: NMT1_2; cl15260 699034005414 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 699034005415 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 699034005416 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 699034005417 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 699034005418 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 699034005419 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 699034005420 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 699034005421 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 699034005422 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 699034005423 tetramer interface [polypeptide binding]; other site 699034005424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034005425 catalytic residue [active] 699034005426 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 699034005427 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 699034005428 tetramer interface [polypeptide binding]; other site 699034005429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034005430 catalytic residue [active] 699034005431 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034005432 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 699034005433 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034005434 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 699034005435 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 699034005436 Protein of unknown function; Region: DUF3658; pfam12395 699034005437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034005438 guanine deaminase; Region: guan_deamin; TIGR02967 699034005439 active site 699034005440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005441 sequence-specific DNA binding site [nucleotide binding]; other site 699034005442 salt bridge; other site 699034005443 Cupin domain; Region: Cupin_2; cl09118 699034005444 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 699034005445 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 699034005446 dimer interface [polypeptide binding]; other site 699034005447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034005448 catalytic residue [active] 699034005449 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 699034005450 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 699034005451 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 699034005452 putative active site [active] 699034005453 catalytic site [active] 699034005454 putative metal binding site [ion binding]; other site 699034005455 maltose O-acetyltransferase; Provisional; Region: PRK10092 699034005456 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 699034005457 active site 699034005458 substrate binding site [chemical binding]; other site 699034005459 trimer interface [polypeptide binding]; other site 699034005460 CoA binding site [chemical binding]; other site 699034005461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034005462 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 699034005463 Walker A/P-loop; other site 699034005464 ATP binding site [chemical binding]; other site 699034005465 Q-loop/lid; other site 699034005466 ABC transporter signature motif; other site 699034005467 Walker B; other site 699034005468 D-loop; other site 699034005469 H-loop/switch region; other site 699034005470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034005471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034005472 active site 699034005473 phosphorylation site [posttranslational modification] 699034005474 intermolecular recognition site; other site 699034005475 dimerization interface [polypeptide binding]; other site 699034005476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034005477 DNA binding site [nucleotide binding] 699034005478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034005479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005480 dimer interface [polypeptide binding]; other site 699034005481 phosphorylation site [posttranslational modification] 699034005482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034005483 TraX protein; Region: TraX; cl05434 699034005484 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034005485 Helix-turn-helix domains; Region: HTH; cl00088 699034005486 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 699034005487 putative substrate binding pocket [chemical binding]; other site 699034005488 AC domain interface; other site 699034005489 catalytic triad [active] 699034005490 AB domain interface; other site 699034005491 interchain disulfide; other site 699034005492 Protein of unknown function (DUF979); Region: DUF979; cl01572 699034005493 Protein of unknown function (DUF969); Region: DUF969; cl01573 699034005494 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034005495 FMN-binding domain; Region: FMN_bind; cl01081 699034005496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034005497 Helix-turn-helix domains; Region: HTH; cl00088 699034005498 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 699034005499 active site 699034005500 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 699034005501 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 699034005502 A new structural DNA glycosylase; Region: AlkD_like; cd06561 699034005503 active site 699034005504 Orotate phosphoribosyltransferase homologs [Nucleotide transport and metabolism]; Region: COG0856 699034005505 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034005506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034005507 active site 699034005508 phosphorylation site [posttranslational modification] 699034005509 intermolecular recognition site; other site 699034005510 dimerization interface [polypeptide binding]; other site 699034005511 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034005512 DNA binding site [nucleotide binding] 699034005513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005514 dimer interface [polypeptide binding]; other site 699034005515 phosphorylation site [posttranslational modification] 699034005516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034005517 ATP binding site [chemical binding]; other site 699034005518 Mg2+ binding site [ion binding]; other site 699034005519 G-X-G motif; other site 699034005520 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 699034005521 catalytic residues [active] 699034005522 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 699034005523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034005524 dimerization interface [polypeptide binding]; other site 699034005525 putative DNA binding site [nucleotide binding]; other site 699034005526 putative Zn2+ binding site [ion binding]; other site 699034005527 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 699034005528 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 699034005529 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 699034005530 transmembrane helices; other site 699034005531 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 699034005532 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 699034005533 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 699034005534 homopentamer interface [polypeptide binding]; other site 699034005535 active site 699034005536 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 699034005537 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 699034005538 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 699034005539 dimerization interface [polypeptide binding]; other site 699034005540 active site 699034005541 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 699034005542 Lumazine binding domain; Region: Lum_binding; pfam00677 699034005543 Lumazine binding domain; Region: Lum_binding; pfam00677 699034005544 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 699034005545 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 699034005546 catalytic motif [active] 699034005547 Zn binding site [ion binding]; other site 699034005548 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 699034005549 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 699034005550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034005551 ATP binding site [chemical binding]; other site 699034005552 putative Mg++ binding site [ion binding]; other site 699034005553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034005554 nucleotide binding region [chemical binding]; other site 699034005555 ATP-binding site [chemical binding]; other site 699034005556 RQC domain; Region: RQC; cl09632 699034005557 HRDC domain; Region: HRDC; cl02578 699034005558 HRDC domain; Region: HRDC; cl02578 699034005559 ThiC family; Region: ThiC; cl08031 699034005560 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 699034005561 thiS-thiF/thiG interaction site; other site 699034005562 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 699034005563 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 699034005564 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 699034005565 putative ATP binding site [chemical binding]; other site 699034005566 putative substrate interface [chemical binding]; other site 699034005567 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 699034005568 ThiS interaction site; other site 699034005569 putative active site [active] 699034005570 tetramer interface [polypeptide binding]; other site 699034005571 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 699034005572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034005573 FeS/SAM binding site; other site 699034005574 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 699034005575 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 699034005576 thiamine phosphate binding site [chemical binding]; other site 699034005577 active site 699034005578 pyrophosphate binding site [ion binding]; other site 699034005579 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 699034005580 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 699034005581 metal binding triad [ion binding]; metal-binding site 699034005582 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 699034005583 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 699034005584 GTP binding site; other site 699034005585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034005586 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 699034005587 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 699034005588 MPT binding site; other site 699034005589 trimer interface [polypeptide binding]; other site 699034005590 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 699034005591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034005592 FeS/SAM binding site; other site 699034005593 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 699034005594 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 699034005595 trimer interface [polypeptide binding]; other site 699034005596 dimer interface [polypeptide binding]; other site 699034005597 putative active site [active] 699034005598 MOSC domain; Region: MOSC; pfam03473 699034005599 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 699034005600 Na binding site [ion binding]; other site 699034005601 Uncharacterized conserved protein [Function unknown]; Region: COG3535 699034005602 Protein of unknown function (DUF917); Region: DUF917; pfam06032 699034005603 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 699034005604 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 699034005605 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 699034005606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 699034005607 putative acyl-acceptor binding pocket; other site 699034005608 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 699034005609 Helix-turn-helix domain; Region: HTH_18; pfam12833 699034005610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034005611 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 699034005612 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 699034005613 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 699034005614 PhoU domain; Region: PhoU; pfam01895 699034005615 PhoU domain; Region: PhoU; pfam01895 699034005616 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 699034005617 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034005618 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 699034005619 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 699034005620 B12 binding site [chemical binding]; other site 699034005621 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 699034005622 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 699034005623 dUMP phosphatase; Provisional; Region: PRK09449 699034005624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034005625 motif II; other site 699034005626 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 699034005627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005628 non-specific DNA binding site [nucleotide binding]; other site 699034005629 salt bridge; other site 699034005630 sequence-specific DNA binding site [nucleotide binding]; other site 699034005631 Cupin domain; Region: Cupin_2; cl09118 699034005632 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 699034005633 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 699034005634 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 699034005635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034005636 substrate binding pocket [chemical binding]; other site 699034005637 membrane-bound complex binding site; other site 699034005638 hinge residues; other site 699034005639 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 699034005640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005641 dimer interface [polypeptide binding]; other site 699034005642 phosphorylation site [posttranslational modification] 699034005643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034005644 ATP binding site [chemical binding]; other site 699034005645 Mg2+ binding site [ion binding]; other site 699034005646 G-X-G motif; other site 699034005647 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 699034005648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034005649 active site 699034005650 phosphorylation site [posttranslational modification] 699034005651 intermolecular recognition site; other site 699034005652 dimerization interface [polypeptide binding]; other site 699034005653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034005654 Walker A motif; other site 699034005655 ATP binding site [chemical binding]; other site 699034005656 Walker B motif; other site 699034005657 arginine finger; other site 699034005658 Helix-turn-helix domains; Region: HTH; cl00088 699034005659 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 699034005660 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 699034005661 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 699034005662 FeoA domain; Region: FeoA; cl00838 699034005663 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 699034005664 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 699034005665 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 699034005666 active site 699034005667 purine riboside binding site [chemical binding]; other site 699034005668 EcsC protein family; Region: EcsC; pfam12787 699034005669 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 699034005670 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 699034005671 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034005672 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 699034005673 active site 699034005674 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005675 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005676 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034005678 Helix-turn-helix domains; Region: HTH; cl00088 699034005679 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034005680 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034005681 Walker A/P-loop; other site 699034005682 ATP binding site [chemical binding]; other site 699034005683 Q-loop/lid; other site 699034005684 ABC transporter signature motif; other site 699034005685 Walker B; other site 699034005686 D-loop; other site 699034005687 H-loop/switch region; other site 699034005688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034005689 non-specific DNA binding site [nucleotide binding]; other site 699034005690 salt bridge; other site 699034005691 sequence-specific DNA binding site [nucleotide binding]; other site 699034005692 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 699034005693 active site 699034005694 catalytic residues [active] 699034005695 metal binding site [ion binding]; metal-binding site 699034005696 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; cl12126 699034005697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034005698 Radical SAM superfamily; Region: Radical_SAM; pfam04055 699034005699 FeS/SAM binding site; other site 699034005700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034005701 S-adenosylmethionine binding site [chemical binding]; other site 699034005702 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034005703 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 699034005704 4Fe-4S binding domain; Region: Fer4; cl02805 699034005705 potential frameshift: common BLAST hit: gi|300855122|ref|YP_003780106.1| epimerase 699034005706 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 699034005707 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 699034005708 B3/4 domain; Region: B3_4; cl11458 699034005709 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 699034005710 dimer interface [polypeptide binding]; other site 699034005711 ADP-ribose binding site [chemical binding]; other site 699034005712 active site 699034005713 nudix motif; other site 699034005714 metal binding site [ion binding]; metal-binding site 699034005715 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 699034005716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034005717 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 699034005718 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034005719 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 699034005720 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034005721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 699034005722 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 699034005723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 699034005724 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 699034005725 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 699034005726 DNA binding site [nucleotide binding] 699034005727 active site 699034005728 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 699034005729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034005730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 699034005731 substrate binding pocket [chemical binding]; other site 699034005732 membrane-bound complex binding site; other site 699034005733 hinge residues; other site 699034005734 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 699034005735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034005736 dimer interface [polypeptide binding]; other site 699034005737 conserved gate region; other site 699034005738 putative PBP binding loops; other site 699034005739 ABC-ATPase subunit interface; other site 699034005740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 699034005741 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034005742 Walker A/P-loop; other site 699034005743 ATP binding site [chemical binding]; other site 699034005744 Q-loop/lid; other site 699034005745 ABC transporter signature motif; other site 699034005746 Walker B; other site 699034005747 D-loop; other site 699034005748 H-loop/switch region; other site 699034005749 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 699034005750 ArsC family; Region: ArsC; pfam03960 699034005751 putative ArsC-like catalytic residues; other site 699034005752 putative TRX-like catalytic residues [active] 699034005753 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 699034005754 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 699034005755 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 699034005756 Ligand Binding Site [chemical binding]; other site 699034005757 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 699034005758 THUMP domain; Region: THUMP; cl12076 699034005759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034005760 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034005761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034005762 active site 699034005763 phosphorylation site [posttranslational modification] 699034005764 intermolecular recognition site; other site 699034005765 dimerization interface [polypeptide binding]; other site 699034005766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034005767 DNA binding site [nucleotide binding] 699034005768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 699034005769 dimerization interface [polypeptide binding]; other site 699034005770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005771 dimer interface [polypeptide binding]; other site 699034005772 phosphorylation site [posttranslational modification] 699034005773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034005774 ATP binding site [chemical binding]; other site 699034005775 Mg2+ binding site [ion binding]; other site 699034005776 G-X-G motif; other site 699034005777 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 699034005778 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 699034005779 dimerization interface 3.5A [polypeptide binding]; other site 699034005780 active site 699034005781 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 699034005782 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 699034005783 ANP binding site [chemical binding]; other site 699034005784 Substrate Binding Site II [chemical binding]; other site 699034005785 Substrate Binding Site I [chemical binding]; other site 699034005786 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 699034005787 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 699034005788 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034005789 DNA binding residues [nucleotide binding] 699034005790 dimer interface [polypeptide binding]; other site 699034005791 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 699034005792 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 699034005793 Protein of unknown function (DUF421); Region: DUF421; cl00990 699034005794 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 699034005795 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 699034005796 active site 699034005797 catalytic site [active] 699034005798 substrate binding site [chemical binding]; other site 699034005799 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 699034005800 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 699034005801 NAD binding site [chemical binding]; other site 699034005802 homodimer interface [polypeptide binding]; other site 699034005803 active site 699034005804 putative substrate binding site [chemical binding]; other site 699034005805 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 699034005806 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 699034005807 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 699034005808 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 699034005809 4Fe-4S binding domain; Region: Fer4; cl02805 699034005810 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 699034005811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034005812 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 699034005813 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 699034005814 active site residue [active] 699034005815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034005816 Helix-turn-helix domains; Region: HTH; cl00088 699034005817 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 699034005818 putative dimerization interface [polypeptide binding]; other site 699034005819 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 699034005820 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 699034005821 putative metal binding site [ion binding]; other site 699034005822 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 699034005823 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 699034005824 putative metal binding site [ion binding]; other site 699034005825 Uncharacterized conserved protein [Function unknown]; Region: COG1284 699034005826 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034005827 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034005828 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 699034005829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034005830 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005831 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005832 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034005833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 699034005834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 699034005835 DNA binding site [nucleotide binding] 699034005836 domain linker motif; other site 699034005837 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 699034005838 dimerization interface [polypeptide binding]; other site 699034005839 ligand binding site [chemical binding]; other site 699034005840 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 699034005841 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 699034005842 substrate binding [chemical binding]; other site 699034005843 active site 699034005844 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 699034005845 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 699034005846 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 699034005847 putative substrate binding site [chemical binding]; other site 699034005848 putative ATP binding site [chemical binding]; other site 699034005849 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034005850 diaminopimelate decarboxylase; Region: PLN02537 699034005851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 699034005852 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034005853 catalytic residue [active] 699034005854 drug efflux system protein MdtG; Provisional; Region: PRK09874 699034005855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034005856 putative substrate translocation pore; other site 699034005857 Helix-turn-helix domains; Region: HTH; cl00088 699034005858 LytTr DNA-binding domain; Region: LytTR; cl04498 699034005859 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 699034005860 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 699034005861 catalytic core [active] 699034005862 HI0933-like protein; Region: HI0933_like; pfam03486 699034005863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034005864 cytidylate kinase; Provisional; Region: cmk; PRK00023 699034005865 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 699034005866 CMP-binding site; other site 699034005867 The sites determining sugar specificity; other site 699034005868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 699034005869 putative acyl-acceptor binding pocket; other site 699034005870 LytB protein; Region: LYTB; cl00507 699034005871 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 699034005872 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 699034005873 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 699034005874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034005875 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 699034005876 active site 699034005877 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034005878 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 699034005879 catalytic triad [active] 699034005880 Protein of unknown function (DUF328); Region: DUF328; cl01143 699034005881 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 699034005882 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 699034005883 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034005884 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 699034005885 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034005886 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 699034005887 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 699034005888 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 699034005889 homodimer interface [polypeptide binding]; other site 699034005890 substrate-cofactor binding pocket; other site 699034005891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034005892 catalytic residue [active] 699034005893 Homoserine O-succinyltransferase; Region: HTS; pfam04204 699034005894 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 699034005895 proposed active site lysine [active] 699034005896 conserved cys residue [active] 699034005897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034005898 Helix-turn-helix domains; Region: HTH; cl00088 699034005899 FtsH Extracellular; Region: FtsH_ext; pfam06480 699034005900 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 699034005901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034005902 Walker A motif; other site 699034005903 ATP binding site [chemical binding]; other site 699034005904 Walker B motif; other site 699034005905 arginine finger; other site 699034005906 Peptidase family M41; Region: Peptidase_M41; pfam01434 699034005907 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 699034005908 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 699034005909 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 699034005910 Ligand Binding Site [chemical binding]; other site 699034005911 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 699034005912 GAF domain; Region: GAF; cl15785 699034005913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034005914 dimer interface [polypeptide binding]; other site 699034005915 phosphorylation site [posttranslational modification] 699034005916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034005917 ATP binding site [chemical binding]; other site 699034005918 Mg2+ binding site [ion binding]; other site 699034005919 G-X-G motif; other site 699034005920 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 699034005921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034005922 active site 699034005923 phosphorylation site [posttranslational modification] 699034005924 intermolecular recognition site; other site 699034005925 dimerization interface [polypeptide binding]; other site 699034005926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034005927 DNA binding site [nucleotide binding] 699034005928 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 699034005929 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 699034005930 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 699034005931 NeuB family; Region: NeuB; cl00496 699034005932 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 699034005933 active site 699034005934 dimer interface [polypeptide binding]; other site 699034005935 metal binding site [ion binding]; metal-binding site 699034005936 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 699034005937 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 699034005938 hinge; other site 699034005939 active site 699034005940 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 699034005941 Tetramer interface [polypeptide binding]; other site 699034005942 active site 699034005943 FMN-binding site [chemical binding]; other site 699034005944 Chorismate mutase type II; Region: CM_2; cl00693 699034005945 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 699034005946 Prephenate dehydratase; Region: PDT; pfam00800 699034005947 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 699034005948 putative L-Phe binding site [chemical binding]; other site 699034005949 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 699034005950 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 699034005951 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 699034005952 shikimate binding site; other site 699034005953 NAD(P) binding site [chemical binding]; other site 699034005954 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 699034005955 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 699034005956 ADP binding site [chemical binding]; other site 699034005957 magnesium binding site [ion binding]; other site 699034005958 putative shikimate binding site; other site 699034005959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034005960 Prephenate dehydrogenase; Region: PDH; pfam02153 699034005961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034005962 metal binding site [ion binding]; metal-binding site 699034005963 active site 699034005964 I-site; other site 699034005965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034005966 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 699034005967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034005968 putative active site [active] 699034005969 heme pocket [chemical binding]; other site 699034005970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 699034005971 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 699034005972 putative active site [active] 699034005973 heme pocket [chemical binding]; other site 699034005974 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 699034005975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034005976 metal binding site [ion binding]; metal-binding site 699034005977 active site 699034005978 I-site; other site 699034005979 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 699034005980 putative active site [active] 699034005981 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 699034005982 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 699034005983 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005984 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005985 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005986 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005987 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005988 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005989 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034005990 Cupin domain; Region: Cupin_2; cl09118 699034005991 NMT1-like family; Region: NMT1_2; cl15260 699034005992 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 699034005993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034005994 S-adenosylmethionine binding site [chemical binding]; other site 699034005995 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 699034005996 Uncharacterized conserved protein [Function unknown]; Region: COG3760 699034005997 putative deacylase active site [active] 699034005998 YtxH-like protein; Region: YtxH; cl02079 699034005999 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034006000 active site 699034006001 metal binding site [ion binding]; metal-binding site 699034006002 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 699034006003 catalytic motif [active] 699034006004 Zn binding site [ion binding]; other site 699034006005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034006006 non-specific DNA binding site [nucleotide binding]; other site 699034006007 salt bridge; other site 699034006008 sequence-specific DNA binding site [nucleotide binding]; other site 699034006009 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 699034006010 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 699034006011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 699034006012 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 699034006013 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 699034006014 catalytic residues [active] 699034006015 catalytic nucleophile [active] 699034006016 Recombinase; Region: Recombinase; pfam07508 699034006017 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 699034006018 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 699034006019 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 699034006020 putative active site [active] 699034006021 metal binding site [ion binding]; metal-binding site 699034006022 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 699034006023 putative hexamer interface [polypeptide binding]; other site 699034006024 putative hexagonal pore; other site 699034006025 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006026 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 699034006027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034006028 active site 699034006029 phosphorylation site [posttranslational modification] 699034006030 intermolecular recognition site; other site 699034006031 dimerization interface [polypeptide binding]; other site 699034006032 ANTAR domain; Region: ANTAR; cl04297 699034006033 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 699034006034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 699034006035 Histidine kinase; Region: HisKA_2; cl06527 699034006036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034006037 Ethanolamine utilisation protein EutA; Region: EutA; pfam06277 699034006038 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 699034006039 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 699034006040 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 699034006041 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 699034006042 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 699034006043 putative hexamer interface [polypeptide binding]; other site 699034006044 putative hexagonal pore; other site 699034006045 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 699034006046 Hexamer interface [polypeptide binding]; other site 699034006047 Hexagonal pore residue; other site 699034006048 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 699034006049 Hexamer interface [polypeptide binding]; other site 699034006050 Hexagonal pore residue; other site 699034006051 50S ribosomal protein L20/unknown domain fusion protein; Provisional; Region: PRK14537 699034006052 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 699034006053 putative catalytic cysteine [active] 699034006054 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 699034006055 Hexamer interface [polypeptide binding]; other site 699034006056 Putative hexagonal pore residue; other site 699034006057 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 699034006058 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 699034006059 Propanediol utilisation protein PduL; Region: PduL; pfam06130 699034006060 Propanediol utilisation protein PduL; Region: PduL; pfam06130 699034006061 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 699034006062 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 699034006063 Hexamer/Pentamer interface [polypeptide binding]; other site 699034006064 central pore; other site 699034006065 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 699034006066 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 699034006067 putative hexamer interface [polypeptide binding]; other site 699034006068 putative hexagonal pore; other site 699034006069 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 699034006070 putative hexamer interface [polypeptide binding]; other site 699034006071 putative hexagonal pore; other site 699034006072 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 699034006073 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 699034006074 Cupin domain; Region: Cupin_2; cl09118 699034006075 Helix-turn-helix domains; Region: HTH; cl00088 699034006076 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034006077 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 699034006078 metal binding site [ion binding]; metal-binding site 699034006079 putative dimer interface [polypeptide binding]; other site 699034006080 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 699034006081 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 699034006082 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 699034006083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034006084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034006085 homodimer interface [polypeptide binding]; other site 699034006086 catalytic residue [active] 699034006087 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 699034006088 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 699034006089 Walker A/P-loop; other site 699034006090 ATP binding site [chemical binding]; other site 699034006091 Q-loop/lid; other site 699034006092 ABC transporter signature motif; other site 699034006093 Walker B; other site 699034006094 D-loop; other site 699034006095 H-loop/switch region; other site 699034006096 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 699034006097 hypothetical protein; Provisional; Region: PRK09040 699034006098 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 699034006099 ligand binding site [chemical binding]; other site 699034006100 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034006101 Helix-turn-helix domains; Region: HTH; cl00088 699034006102 LexA repressor; Validated; Region: PRK00215 699034006103 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 699034006104 Catalytic site [active] 699034006105 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 699034006106 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034006107 active site 699034006108 DNA binding site [nucleotide binding] 699034006109 Int/Topo IB signature motif; other site 699034006110 Uncharacterized conserved protein [Function unknown]; Region: COG3603 699034006111 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 699034006112 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 699034006113 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 699034006114 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 699034006115 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 699034006116 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 699034006117 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 699034006118 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 699034006119 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034006120 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 699034006121 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 699034006122 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 699034006123 carboxyltransferase (CT) interaction site; other site 699034006124 biotinylation site [posttranslational modification]; other site 699034006125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034006126 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 699034006127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 699034006128 active site 699034006129 metal binding site [ion binding]; metal-binding site 699034006130 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 699034006131 Helix-turn-helix domain; Region: HTH_18; pfam12833 699034006132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034006133 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034006134 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034006135 Walker A/P-loop; other site 699034006136 ATP binding site [chemical binding]; other site 699034006137 Q-loop/lid; other site 699034006138 ABC transporter signature motif; other site 699034006139 Walker B; other site 699034006140 D-loop; other site 699034006141 H-loop/switch region; other site 699034006142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034006143 FtsX-like permease family; Region: FtsX; cl15850 699034006144 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034006145 FtsX-like permease family; Region: FtsX; cl15850 699034006146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034006147 dimer interface [polypeptide binding]; other site 699034006148 phosphorylation site [posttranslational modification] 699034006149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034006150 ATP binding site [chemical binding]; other site 699034006151 Mg2+ binding site [ion binding]; other site 699034006152 G-X-G motif; other site 699034006153 Uncharacterized conserved protein [Function unknown]; Region: COG1284 699034006154 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034006155 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 699034006156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 699034006157 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034006158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034006159 Helix-turn-helix domains; Region: HTH; cl00088 699034006160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 699034006161 dimerization interface [polypeptide binding]; other site 699034006162 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 699034006163 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 699034006164 FtsX-like permease family; Region: FtsX; cl15850 699034006165 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 699034006166 FtsX-like permease family; Region: FtsX; cl15850 699034006167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034006168 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034006169 Walker A/P-loop; other site 699034006170 ATP binding site [chemical binding]; other site 699034006171 Q-loop/lid; other site 699034006172 ABC transporter signature motif; other site 699034006173 Walker B; other site 699034006174 D-loop; other site 699034006175 H-loop/switch region; other site 699034006176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034006177 dimer interface [polypeptide binding]; other site 699034006178 phosphorylation site [posttranslational modification] 699034006179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034006180 ATP binding site [chemical binding]; other site 699034006181 Mg2+ binding site [ion binding]; other site 699034006182 G-X-G motif; other site 699034006183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034006184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034006185 active site 699034006186 phosphorylation site [posttranslational modification] 699034006187 intermolecular recognition site; other site 699034006188 dimerization interface [polypeptide binding]; other site 699034006189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034006190 DNA binding site [nucleotide binding] 699034006191 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 699034006192 iron-sulfur cluster binding protein, putative; Region: TIGR00276 699034006193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034006194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034006195 active site 699034006196 phosphorylation site [posttranslational modification] 699034006197 intermolecular recognition site; other site 699034006198 dimerization interface [polypeptide binding]; other site 699034006199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034006200 DNA binding site [nucleotide binding] 699034006201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034006202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034006203 dimer interface [polypeptide binding]; other site 699034006204 phosphorylation site [posttranslational modification] 699034006205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034006206 ATP binding site [chemical binding]; other site 699034006207 Mg2+ binding site [ion binding]; other site 699034006208 G-X-G motif; other site 699034006209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034006210 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034006211 Walker A/P-loop; other site 699034006212 ATP binding site [chemical binding]; other site 699034006213 Q-loop/lid; other site 699034006214 ABC transporter signature motif; other site 699034006215 Walker B; other site 699034006216 D-loop; other site 699034006217 H-loop/switch region; other site 699034006218 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034006219 FtsX-like permease family; Region: FtsX; cl15850 699034006220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034006221 FtsX-like permease family; Region: FtsX; cl15850 699034006222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034006223 S-adenosylmethionine binding site [chemical binding]; other site 699034006224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034006225 WHG domain; Region: WHG; pfam13305 699034006226 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 699034006227 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 699034006228 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034006229 Protein of unknown function (DUF554); Region: DUF554; cl00784 699034006230 Uncharacterized conserved protein [Function unknown]; Region: COG3760 699034006231 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 699034006232 putative deacylase active site [active] 699034006233 Putative cyclase; Region: Cyclase; cl00814 699034006234 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 699034006235 hypothetical protein; Provisional; Region: PRK07205 699034006236 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 699034006237 active site 699034006238 metal binding site [ion binding]; metal-binding site 699034006239 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 699034006240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034006241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034006242 catalytic residue [active] 699034006243 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 699034006244 Sm1 motif; other site 699034006245 D1 - D2 interaction site; other site 699034006246 D3 - B interaction site; other site 699034006247 Hfq - Hfq interaction site; other site 699034006248 RNA binding pocket [nucleotide binding]; other site 699034006249 Sm2 motif; other site 699034006250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006251 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 699034006252 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 699034006253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034006254 ATP binding site [chemical binding]; other site 699034006255 Mg2+ binding site [ion binding]; other site 699034006256 G-X-G motif; other site 699034006257 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 699034006258 ATP binding site [chemical binding]; other site 699034006259 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 699034006260 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 699034006261 MutS domain I; Region: MutS_I; pfam01624 699034006262 MutS family domain IV; Region: MutS_IV; pfam05190 699034006263 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 699034006264 Walker A/P-loop; other site 699034006265 ATP binding site [chemical binding]; other site 699034006266 Q-loop/lid; other site 699034006267 ABC transporter signature motif; other site 699034006268 Walker B; other site 699034006269 D-loop; other site 699034006270 H-loop/switch region; other site 699034006271 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 699034006272 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 699034006273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034006274 Walker A/P-loop; other site 699034006275 ATP binding site [chemical binding]; other site 699034006276 Q-loop/lid; other site 699034006277 ABC transporter signature motif; other site 699034006278 Walker B; other site 699034006279 D-loop; other site 699034006280 H-loop/switch region; other site 699034006281 NMT1-like family; Region: NMT1_2; cl15260 699034006282 NMT1/THI5 like; Region: NMT1; pfam09084 699034006283 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 699034006284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034006285 dimer interface [polypeptide binding]; other site 699034006286 conserved gate region; other site 699034006287 putative PBP binding loops; other site 699034006288 ABC-ATPase subunit interface; other site 699034006289 Domain of unknown function DUF77; Region: DUF77; cl00307 699034006290 Helix-turn-helix domains; Region: HTH; cl00088 699034006291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034006292 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034006293 Probable transposase; Region: OrfB_IS605; pfam01385 699034006294 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034006295 potential frameshift: common BLAST hit: gi|300854958|ref|YP_003779942.1| epimerase 699034006296 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 699034006297 putative active site [active] 699034006298 putative CoA binding site [chemical binding]; other site 699034006299 nudix motif; other site 699034006300 metal binding site [ion binding]; metal-binding site 699034006301 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 699034006302 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 699034006303 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 699034006304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034006305 FeS/SAM binding site; other site 699034006306 TRAM domain; Region: TRAM; cl01282 699034006307 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034006308 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034006309 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034006310 Bacterial SH3 domain; Region: SH3_3; cl02551 699034006311 Helix-turn-helix domains; Region: HTH; cl00088 699034006312 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 699034006313 DNA-binding site [nucleotide binding]; DNA binding site 699034006314 RNA-binding motif; other site 699034006315 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 699034006316 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 699034006317 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 699034006318 SdpI/YhfL protein family; Region: SdpI; pfam13630 699034006319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034006320 dimerization interface [polypeptide binding]; other site 699034006321 putative DNA binding site [nucleotide binding]; other site 699034006322 putative Zn2+ binding site [ion binding]; other site 699034006323 Cupin domain; Region: Cupin_2; cl09118 699034006324 Sensory domain found in PocR; Region: PocR; pfam10114 699034006325 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 699034006326 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 699034006327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034006328 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 699034006329 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 699034006330 DNA binding residues [nucleotide binding] 699034006331 putative dimer interface [polypeptide binding]; other site 699034006332 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 699034006333 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 699034006334 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034006335 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 699034006336 active site 699034006337 catalytic residues [active] 699034006338 Dehydratase family; Region: ILVD_EDD; cl00340 699034006339 VanZ like family; Region: VanZ; cl01971 699034006340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034006341 non-specific DNA binding site [nucleotide binding]; other site 699034006342 salt bridge; other site 699034006343 sequence-specific DNA binding site [nucleotide binding]; other site 699034006344 Cupin domain; Region: Cupin_2; cl09118 699034006345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034006346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034006347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034006348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034006349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034006350 putative substrate translocation pore; other site 699034006351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034006352 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 699034006353 Clp amino terminal domain; Region: Clp_N; pfam02861 699034006354 Clp amino terminal domain; Region: Clp_N; pfam02861 699034006355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034006356 Walker A motif; other site 699034006357 ATP binding site [chemical binding]; other site 699034006358 Walker B motif; other site 699034006359 arginine finger; other site 699034006360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034006361 Walker A motif; other site 699034006362 ATP binding site [chemical binding]; other site 699034006363 Walker B motif; other site 699034006364 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 699034006365 Helix-turn-helix domains; Region: HTH; cl00088 699034006366 Predicted transcriptional regulators [Transcription]; Region: COG1725 699034006367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034006368 DNA-binding site [nucleotide binding]; DNA binding site 699034006369 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034006370 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034006371 Walker A/P-loop; other site 699034006372 ATP binding site [chemical binding]; other site 699034006373 Q-loop/lid; other site 699034006374 ABC transporter signature motif; other site 699034006375 Walker B; other site 699034006376 D-loop; other site 699034006377 H-loop/switch region; other site 699034006378 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 699034006379 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 699034006380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034006381 Coenzyme A binding pocket [chemical binding]; other site 699034006382 allantoate amidohydrolase; Reviewed; Region: PRK09290 699034006383 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 699034006384 active site 699034006385 metal binding site [ion binding]; metal-binding site 699034006386 dimer interface [polypeptide binding]; other site 699034006387 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 699034006388 ornithine carbamoyltransferase; Validated; Region: PRK02102 699034006389 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 699034006390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034006391 acetylornithine aminotransferase; Provisional; Region: PRK02627 699034006392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 699034006393 inhibitor-cofactor binding pocket; inhibition site 699034006394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034006395 catalytic residue [active] 699034006396 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 699034006397 feedback inhibition sensing region; other site 699034006398 homohexameric interface [polypeptide binding]; other site 699034006399 nucleotide binding site [chemical binding]; other site 699034006400 N-acetyl-L-glutamate binding site [chemical binding]; other site 699034006401 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 699034006402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034006403 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 699034006404 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 699034006405 YoaP-like; Region: YoaP; pfam14268 699034006406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 699034006407 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034006408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034006409 Helix-turn-helix domains; Region: HTH; cl00088 699034006410 WHG domain; Region: WHG; pfam13305 699034006411 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 699034006412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034006413 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034006414 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034006415 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034006416 putative active site [active] 699034006417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034006418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034006419 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 699034006420 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 699034006421 RNA binding surface [nucleotide binding]; other site 699034006422 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 699034006423 active site 699034006424 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 699034006425 diaminopimelate decarboxylase; Region: lysA; TIGR01048 699034006426 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 699034006427 active site 699034006428 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034006429 substrate binding site [chemical binding]; other site 699034006430 catalytic residues [active] 699034006431 dimer interface [polypeptide binding]; other site 699034006432 aspartate kinase; Reviewed; Region: PRK06635 699034006433 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 699034006434 putative nucleotide binding site [chemical binding]; other site 699034006435 putative catalytic residues [active] 699034006436 putative Mg ion binding site [ion binding]; other site 699034006437 putative aspartate binding site [chemical binding]; other site 699034006438 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 699034006439 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 699034006440 putative allosteric regulatory residue; other site 699034006441 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 699034006442 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 699034006443 active site 699034006444 HIGH motif; other site 699034006445 nucleotide binding site [chemical binding]; other site 699034006446 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 699034006447 KMSKS motif; other site 699034006448 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 699034006449 putative lipid kinase; Reviewed; Region: PRK13059 699034006450 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 699034006451 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 699034006452 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 699034006453 Helix-turn-helix domains; Region: HTH; cl00088 699034006454 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 699034006455 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 699034006456 Int/Topo IB signature motif; other site 699034006457 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 699034006458 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006459 Walker A/P-loop; other site 699034006460 ATP binding site [chemical binding]; other site 699034006461 ABC transporter signature motif; other site 699034006462 Walker B; other site 699034006463 D-loop; other site 699034006464 H-loop/switch region; other site 699034006465 ABC transporter; Region: ABC_tran_2; pfam12848 699034006466 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034006467 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 699034006468 putative MPT binding site; other site 699034006469 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 699034006470 Ligand binding site; other site 699034006471 metal-binding site 699034006472 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 699034006473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034006474 Probable transposase; Region: OrfB_IS605; pfam01385 699034006475 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034006476 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 699034006477 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 699034006478 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 699034006479 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 699034006480 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 699034006481 xanthine permease; Region: pbuX; TIGR03173 699034006482 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 699034006483 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 699034006484 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 699034006485 phosphate binding site [ion binding]; other site 699034006486 4Fe-4S binding domain; Region: Fer4; cl02805 699034006487 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 699034006488 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 699034006489 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034006490 active site 699034006491 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 699034006492 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 699034006493 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 699034006494 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 699034006495 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 699034006496 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 699034006497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 699034006498 catalytic loop [active] 699034006499 iron binding site [ion binding]; other site 699034006500 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 699034006501 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 699034006502 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 699034006503 active site 699034006504 putative substrate binding pocket [chemical binding]; other site 699034006505 phenylhydantoinase; Validated; Region: PRK08323 699034006506 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 699034006507 tetramer interface [polypeptide binding]; other site 699034006508 active site 699034006509 peptidase; Reviewed; Region: PRK13004 699034006510 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 699034006511 putative metal binding site [ion binding]; other site 699034006512 putative dimer interface [polypeptide binding]; other site 699034006513 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 699034006514 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 699034006515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034006516 catalytic residue [active] 699034006517 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034006518 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 699034006519 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 699034006520 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 699034006521 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 699034006522 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 699034006523 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 699034006524 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 699034006525 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 699034006526 active site 699034006527 putative substrate binding pocket [chemical binding]; other site 699034006528 xanthine permease; Region: pbuX; TIGR03173 699034006529 xanthine permease; Region: pbuX; TIGR03173 699034006530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034006531 Walker A motif; other site 699034006532 ATP binding site [chemical binding]; other site 699034006533 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 699034006534 Walker B motif; other site 699034006535 arginine finger; other site 699034006536 Helix-turn-helix domains; Region: HTH; cl00088 699034006537 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 699034006538 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 699034006539 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006540 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 699034006541 Predicted transcriptional regulator [Transcription]; Region: COG2378 699034006542 Helix-turn-helix domains; Region: HTH; cl00088 699034006543 WYL domain; Region: WYL; cl14852 699034006544 QueT transporter; Region: QueT; cl01932 699034006545 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 699034006546 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 699034006547 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 699034006548 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 699034006549 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 699034006550 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 699034006551 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 699034006552 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 699034006553 potassium/proton antiporter; Reviewed; Region: PRK05326 699034006554 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 699034006555 Predicted integral membrane protein [Function unknown]; Region: COG0392 699034006556 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 699034006557 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 699034006558 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034006559 Walker A/P-loop; other site 699034006560 ATP binding site [chemical binding]; other site 699034006561 Q-loop/lid; other site 699034006562 ABC transporter signature motif; other site 699034006563 Walker B; other site 699034006564 D-loop; other site 699034006565 H-loop/switch region; other site 699034006566 helicase 45; Provisional; Region: PTZ00424 699034006567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006568 ATP binding site [chemical binding]; other site 699034006569 putative Mg++ binding site [ion binding]; other site 699034006570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034006571 nucleotide binding region [chemical binding]; other site 699034006572 ATP-binding site [chemical binding]; other site 699034006573 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 699034006574 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 699034006575 MatE; Region: MatE; cl10513 699034006576 MatE; Region: MatE; cl10513 699034006577 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 699034006578 transmembrane helices; other site 699034006579 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 699034006580 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 699034006581 active site 699034006582 intersubunit interactions; other site 699034006583 catalytic residue [active] 699034006584 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 699034006585 Helix-turn-helix domains; Region: HTH; cl00088 699034006586 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034006587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034006588 dimer interface [polypeptide binding]; other site 699034006589 phosphorylation site [posttranslational modification] 699034006590 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 699034006591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034006592 ATP binding site [chemical binding]; other site 699034006593 G-X-G motif; other site 699034006594 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 699034006595 Helix-turn-helix domains; Region: HTH; cl00088 699034006596 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 699034006597 metal-binding site [ion binding] 699034006598 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 699034006599 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 699034006600 metal-binding site [ion binding] 699034006601 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034006602 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034006603 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 699034006604 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 699034006605 G1 box; other site 699034006606 putative GEF interaction site [polypeptide binding]; other site 699034006607 GTP/Mg2+ binding site [chemical binding]; other site 699034006608 Switch I region; other site 699034006609 G2 box; other site 699034006610 G3 box; other site 699034006611 Switch II region; other site 699034006612 G4 box; other site 699034006613 G5 box; other site 699034006614 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 699034006615 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 699034006616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034006617 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 699034006618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034006619 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 699034006620 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 699034006621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034006622 catalytic residue [active] 699034006623 homoserine kinase; Provisional; Region: PRK01212 699034006624 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 699034006625 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 699034006626 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 699034006627 FMN binding site [chemical binding]; other site 699034006628 substrate binding site [chemical binding]; other site 699034006629 putative catalytic residue [active] 699034006630 Flavin Reductases; Region: FlaRed; cl00801 699034006631 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 699034006632 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 699034006633 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 699034006634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034006635 binding surface 699034006636 TPR motif; other site 699034006637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034006638 binding surface 699034006639 TPR motif; other site 699034006640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034006641 binding surface 699034006642 TPR motif; other site 699034006643 TPR repeat; Region: TPR_11; pfam13414 699034006644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 699034006645 binding surface 699034006646 TPR motif; other site 699034006647 Membrane transport protein; Region: Mem_trans; cl09117 699034006648 putative acetyltransferase YhhY; Provisional; Region: PRK10140 699034006649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034006650 Coenzyme A binding pocket [chemical binding]; other site 699034006651 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034006652 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 699034006653 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 699034006654 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 699034006655 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 699034006656 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 699034006657 active site 699034006658 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 699034006659 protein binding site [polypeptide binding]; other site 699034006660 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 699034006661 putative substrate binding region [chemical binding]; other site 699034006662 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 699034006663 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 699034006664 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 699034006665 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 699034006666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034006667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034006668 metal binding site [ion binding]; metal-binding site 699034006669 active site 699034006670 I-site; other site 699034006671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034006672 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 699034006673 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 699034006674 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 699034006675 catalytic residue [active] 699034006676 putative FPP diphosphate binding site; other site 699034006677 putative FPP binding hydrophobic cleft; other site 699034006678 dimer interface [polypeptide binding]; other site 699034006679 putative IPP diphosphate binding site; other site 699034006680 ribosome recycling factor; Reviewed; Region: frr; PRK00083 699034006681 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 699034006682 hinge region; other site 699034006683 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 699034006684 putative nucleotide binding site [chemical binding]; other site 699034006685 uridine monophosphate binding site [chemical binding]; other site 699034006686 homohexameric interface [polypeptide binding]; other site 699034006687 elongation factor Ts; Provisional; Region: tsf; PRK09377 699034006688 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 699034006689 Elongation factor TS; Region: EF_TS; pfam00889 699034006690 Elongation factor TS; Region: EF_TS; pfam00889 699034006691 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 699034006692 rRNA interaction site [nucleotide binding]; other site 699034006693 S8 interaction site; other site 699034006694 putative laminin-1 binding site; other site 699034006695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034006696 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 699034006697 voltage-gated potassium channel; Provisional; Region: PRK10537 699034006698 Ion channel; Region: Ion_trans_2; cl11596 699034006699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034006700 sequence-specific DNA binding site [nucleotide binding]; other site 699034006701 salt bridge; other site 699034006702 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 699034006703 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 699034006704 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 699034006705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006706 Walker A/P-loop; other site 699034006707 ATP binding site [chemical binding]; other site 699034006708 Q-loop/lid; other site 699034006709 ABC transporter signature motif; other site 699034006710 Walker B; other site 699034006711 D-loop; other site 699034006712 H-loop/switch region; other site 699034006713 hypothetical protein; Reviewed; Region: PRK09588 699034006714 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 699034006715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 699034006716 active site 699034006717 ATP binding site [chemical binding]; other site 699034006718 substrate binding site [chemical binding]; other site 699034006719 activation loop (A-loop); other site 699034006720 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 699034006721 VanW like protein; Region: VanW; pfam04294 699034006722 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 699034006723 putative catalytic site [active] 699034006724 putative metal binding site [ion binding]; other site 699034006725 putative phosphate binding site [ion binding]; other site 699034006726 Protein of unknown function (DUF819); Region: DUF819; cl02317 699034006727 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 699034006728 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 699034006729 putative oligomer interface [polypeptide binding]; other site 699034006730 putative active site [active] 699034006731 metal binding site [ion binding]; metal-binding site 699034006732 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 699034006733 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 699034006734 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 699034006735 G1 box; other site 699034006736 GTP/Mg2+ binding site [chemical binding]; other site 699034006737 Switch I region; other site 699034006738 G2 box; other site 699034006739 Switch II region; other site 699034006740 G3 box; other site 699034006741 G4 box; other site 699034006742 G5 box; other site 699034006743 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 699034006744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034006745 FeS/SAM binding site; other site 699034006746 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 699034006747 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 699034006748 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 699034006749 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 699034006750 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 699034006751 inhibitor-cofactor binding pocket; inhibition site 699034006752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034006753 catalytic residue [active] 699034006754 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 699034006755 VanZ like family; Region: VanZ; cl01971 699034006756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034006757 Coenzyme A binding pocket [chemical binding]; other site 699034006758 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 699034006759 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 699034006760 DHHA1 domain; Region: DHHA1; pfam02272 699034006761 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 699034006762 tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034006763 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 699034006764 NAD binding site [chemical binding]; other site 699034006765 dimer interface [polypeptide binding]; other site 699034006766 substrate binding site [chemical binding]; other site 699034006767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034006768 Domain of unknown function (DUF955); Region: DUF955; cl01076 699034006769 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 699034006770 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 699034006771 SelR domain; Region: SelR; pfam01641 699034006772 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 699034006773 active site 699034006774 nucleophile elbow; other site 699034006775 hybrid cluster protein; Provisional; Region: PRK05290 699034006776 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034006777 ACS interaction site; other site 699034006778 CODH interaction site; other site 699034006779 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 699034006780 hybrid metal cluster; other site 699034006781 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 699034006782 4Fe-4S binding domain; Region: Fer4; cl02805 699034006783 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 699034006784 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 699034006785 ligand binding site [chemical binding]; other site 699034006786 Helix-turn-helix domains; Region: HTH; cl00088 699034006787 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 699034006788 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 699034006789 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 699034006790 Walker A/P-loop; other site 699034006791 ATP binding site [chemical binding]; other site 699034006792 Q-loop/lid; other site 699034006793 ABC transporter signature motif; other site 699034006794 Walker B; other site 699034006795 D-loop; other site 699034006796 H-loop/switch region; other site 699034006797 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034006798 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 699034006799 metal binding site [ion binding]; metal-binding site 699034006800 dimer interface [polypeptide binding]; other site 699034006801 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 699034006802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034006803 substrate binding pocket [chemical binding]; other site 699034006804 membrane-bound complex binding site; other site 699034006805 hinge residues; other site 699034006806 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 699034006807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034006808 dimer interface [polypeptide binding]; other site 699034006809 conserved gate region; other site 699034006810 putative PBP binding loops; other site 699034006811 ABC-ATPase subunit interface; other site 699034006812 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 699034006813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034006814 dimer interface [polypeptide binding]; other site 699034006815 conserved gate region; other site 699034006816 putative PBP binding loops; other site 699034006817 ABC-ATPase subunit interface; other site 699034006818 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 699034006819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 699034006820 substrate binding pocket [chemical binding]; other site 699034006821 membrane-bound complex binding site; other site 699034006822 hinge residues; other site 699034006823 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 699034006824 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 699034006825 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 699034006826 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 699034006827 putative [Fe4-S4] binding site [ion binding]; other site 699034006828 putative molybdopterin cofactor binding site [chemical binding]; other site 699034006829 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 699034006830 molybdopterin cofactor binding site; other site 699034006831 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 699034006832 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 699034006833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034006834 ATP binding site [chemical binding]; other site 699034006835 putative Mg++ binding site [ion binding]; other site 699034006836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034006837 nucleotide binding region [chemical binding]; other site 699034006838 ATP-binding site [chemical binding]; other site 699034006839 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034006840 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 699034006841 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 699034006842 ATP binding site [chemical binding]; other site 699034006843 Mg++ binding site [ion binding]; other site 699034006844 motif III; other site 699034006845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034006846 nucleotide binding region [chemical binding]; other site 699034006847 ATP-binding site [chemical binding]; other site 699034006848 DbpA RNA binding domain; Region: DbpA; pfam03880 699034006849 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034006850 active site 699034006851 metal binding site [ion binding]; metal-binding site 699034006852 Fibronectin type III-like domain; Region: Fn3-like; cl15273 699034006853 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 699034006854 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 699034006855 maltose phosphorylase; Provisional; Region: PRK13807 699034006856 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 699034006857 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 699034006858 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 699034006859 beta-phosphoglucomutase; Region: bPGM; TIGR01990 699034006860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034006861 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 699034006862 homodimer interface [polypeptide binding]; other site 699034006863 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 699034006864 active site 699034006865 homodimer interface [polypeptide binding]; other site 699034006866 catalytic site [active] 699034006867 histidinol-phosphatase; Provisional; Region: PRK05588 699034006868 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034006869 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034006870 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034006871 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 699034006872 Helix-turn-helix domains; Region: HTH; cl00088 699034006873 non-specific DNA interactions [nucleotide binding]; other site 699034006874 DNA binding site [nucleotide binding] 699034006875 sequence specific DNA binding site [nucleotide binding]; other site 699034006876 putative cAMP binding site [chemical binding]; other site 699034006877 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 699034006878 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034006879 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 699034006880 Ferritin-like domain; Region: Ferritin; pfam00210 699034006881 ferroxidase diiron center [ion binding]; other site 699034006882 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 699034006883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034006884 CoA-ligase; Region: Ligase_CoA; cl02894 699034006885 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034006886 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 699034006887 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 699034006888 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 699034006889 TPP-binding site [chemical binding]; other site 699034006890 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 699034006891 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 699034006892 dimer interface [polypeptide binding]; other site 699034006893 PYR/PP interface [polypeptide binding]; other site 699034006894 TPP binding site [chemical binding]; other site 699034006895 substrate binding site [chemical binding]; other site 699034006896 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 699034006897 hypothetical protein; Provisional; Region: PRK13795 699034006898 4Fe-4S binding domain; Region: Fer4; cl02805 699034006899 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 699034006900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034006901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034006902 homodimer interface [polypeptide binding]; other site 699034006903 catalytic residue [active] 699034006904 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 699034006905 MFS/sugar transport protein; Region: MFS_2; pfam13347 699034006906 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 699034006907 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 699034006908 Na binding site [ion binding]; other site 699034006909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034006910 Helix-turn-helix domains; Region: HTH; cl00088 699034006911 Putative esterase; Region: Esterase; pfam00756 699034006912 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034006913 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 699034006914 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 699034006915 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 699034006916 NAD(P) binding site [chemical binding]; other site 699034006917 catalytic residues [active] 699034006918 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034006919 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034006920 Helix-turn-helix domains; Region: HTH; cl00088 699034006921 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 699034006922 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 699034006923 HflX GTPase family; Region: HflX; cd01878 699034006924 G1 box; other site 699034006925 GTP/Mg2+ binding site [chemical binding]; other site 699034006926 Switch I region; other site 699034006927 G2 box; other site 699034006928 G3 box; other site 699034006929 Switch II region; other site 699034006930 G4 box; other site 699034006931 G5 box; other site 699034006932 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034006933 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034006934 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 699034006935 Walker A/P-loop; other site 699034006936 ATP binding site [chemical binding]; other site 699034006937 Q-loop/lid; other site 699034006938 ABC transporter signature motif; other site 699034006939 Walker B; other site 699034006940 D-loop; other site 699034006941 H-loop/switch region; other site 699034006942 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034006943 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034006944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034006945 Walker A/P-loop; other site 699034006946 ATP binding site [chemical binding]; other site 699034006947 Q-loop/lid; other site 699034006948 ABC transporter signature motif; other site 699034006949 Walker B; other site 699034006950 D-loop; other site 699034006951 H-loop/switch region; other site 699034006952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034006953 Helix-turn-helix domains; Region: HTH; cl00088 699034006954 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 699034006955 active site clefts [active] 699034006956 zinc binding site [ion binding]; other site 699034006957 dimer interface [polypeptide binding]; other site 699034006958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034006959 non-specific DNA binding site [nucleotide binding]; other site 699034006960 salt bridge; other site 699034006961 sequence-specific DNA binding site [nucleotide binding]; other site 699034006962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034006963 non-specific DNA binding site [nucleotide binding]; other site 699034006964 salt bridge; other site 699034006965 sequence-specific DNA binding site [nucleotide binding]; other site 699034006966 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 699034006967 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 699034006968 active site 699034006969 catalytic residue [active] 699034006970 dimer interface [polypeptide binding]; other site 699034006971 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 699034006972 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 699034006973 trimer interface [polypeptide binding]; other site 699034006974 active site 699034006975 substrate binding site [chemical binding]; other site 699034006976 CoA binding site [chemical binding]; other site 699034006977 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 699034006978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034006979 FeS/SAM binding site; other site 699034006980 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 699034006981 Predicted membrane protein [Function unknown]; Region: COG4129 699034006982 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 699034006983 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 699034006984 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 699034006985 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 699034006986 4Fe-4S binding domain; Region: Fer4; cl02805 699034006987 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 699034006988 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 699034006989 FAD binding pocket [chemical binding]; other site 699034006990 FAD binding motif [chemical binding]; other site 699034006991 phosphate binding motif [ion binding]; other site 699034006992 beta-alpha-beta structure motif; other site 699034006993 NAD binding pocket [chemical binding]; other site 699034006994 Iron coordination center [ion binding]; other site 699034006995 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 699034006996 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034006997 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 699034006998 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 699034006999 ligand binding site [chemical binding]; other site 699034007000 flexible hinge region; other site 699034007001 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 699034007002 putative switch regulator; other site 699034007003 non-specific DNA interactions [nucleotide binding]; other site 699034007004 DNA binding site [nucleotide binding] 699034007005 sequence specific DNA binding site [nucleotide binding]; other site 699034007006 putative cAMP binding site [chemical binding]; other site 699034007007 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034007008 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034007009 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034007010 putative active site [active] 699034007011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 699034007012 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034007013 Domain of unknown function (DUF303); Region: DUF303; pfam03629 699034007014 Domain of unknown function (DUF386); Region: DUF386; cl01047 699034007015 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 699034007016 Na binding site [ion binding]; other site 699034007017 N-acetylneuraminate lyase; Region: nanA; TIGR00683 699034007018 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 699034007019 inhibitor site; inhibition site 699034007020 active site 699034007021 dimer interface [polypeptide binding]; other site 699034007022 catalytic residue [active] 699034007023 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 699034007024 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 699034007025 putative active site cavity [active] 699034007026 Double zinc ribbon; Region: DZR; pfam12773 699034007027 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 699034007028 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034007029 metal binding site [ion binding]; metal-binding site 699034007030 active site 699034007031 I-site; other site 699034007032 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 699034007033 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 699034007034 putative dimer interface [polypeptide binding]; other site 699034007035 putative anticodon binding site; other site 699034007036 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 699034007037 homodimer interface [polypeptide binding]; other site 699034007038 motif 1; other site 699034007039 motif 2; other site 699034007040 active site 699034007041 motif 3; other site 699034007042 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 699034007043 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 699034007044 active site 699034007045 catalytic triad [active] 699034007046 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 699034007047 active site 699034007048 catalytic triad [active] 699034007049 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 699034007050 active site 699034007051 catalytic triad [active] 699034007052 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 699034007053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 699034007054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034007055 Walker A motif; other site 699034007056 ATP binding site [chemical binding]; other site 699034007057 Walker B motif; other site 699034007058 arginine finger; other site 699034007059 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 699034007060 Domain of unknown function DUF20; Region: UPF0118; pfam01594 699034007061 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 699034007062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034007063 FeS/SAM binding site; other site 699034007064 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 699034007065 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 699034007066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034007067 DNA-binding site [nucleotide binding]; DNA binding site 699034007068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007070 homodimer interface [polypeptide binding]; other site 699034007071 catalytic residue [active] 699034007072 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 699034007073 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034007074 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 699034007075 Cupin domain; Region: Cupin_2; cl09118 699034007076 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 699034007077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034007078 putative substrate translocation pore; other site 699034007079 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 699034007080 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 699034007081 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 699034007082 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 699034007083 active site 699034007084 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034007085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 699034007086 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 699034007087 PPIC-type PPIASE domain; Region: Rotamase; cl08278 699034007088 FAD dependent oxidoreductase; Region: DAO; pfam01266 699034007089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034007090 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 699034007091 [2Fe-2S] cluster binding site [ion binding]; other site 699034007092 CAAX protease self-immunity; Region: Abi; cl00558 699034007093 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 699034007094 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007095 active site 699034007096 phosphorylation site [posttranslational modification] 699034007097 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034007098 active site 699034007099 P-loop; other site 699034007100 phosphorylation site [posttranslational modification] 699034007101 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034007102 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 699034007103 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 699034007104 putative substrate binding site [chemical binding]; other site 699034007105 putative ATP binding site [chemical binding]; other site 699034007106 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034007107 Helix-turn-helix domains; Region: HTH; cl00088 699034007108 Helix-turn-helix domains; Region: HTH; cl00088 699034007109 PRD domain; Region: PRD; cl15445 699034007110 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034007111 active site 699034007112 P-loop; other site 699034007113 phosphorylation site [posttranslational modification] 699034007114 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007115 active site 699034007116 phosphorylation site [posttranslational modification] 699034007117 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 699034007118 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 699034007119 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 699034007120 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 699034007121 Domain of unknown function DUF20; Region: UPF0118; pfam01594 699034007122 DNA topoisomerase III; Provisional; Region: PRK07726 699034007123 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 699034007124 active site 699034007125 putative interdomain interaction site [polypeptide binding]; other site 699034007126 putative metal-binding site [ion binding]; other site 699034007127 putative nucleotide binding site [chemical binding]; other site 699034007128 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 699034007129 domain I; other site 699034007130 DNA binding groove [nucleotide binding] 699034007131 phosphate binding site [ion binding]; other site 699034007132 domain II; other site 699034007133 domain III; other site 699034007134 nucleotide binding site [chemical binding]; other site 699034007135 catalytic site [active] 699034007136 domain IV; other site 699034007137 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 699034007138 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 699034007139 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 699034007140 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 699034007141 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 699034007142 intersubunit interface [polypeptide binding]; other site 699034007143 active site 699034007144 Zn2+ binding site [ion binding]; other site 699034007145 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 699034007146 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 699034007147 intersubunit interface [polypeptide binding]; other site 699034007148 active site 699034007149 Zn2+ binding site [ion binding]; other site 699034007150 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 699034007151 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 699034007152 putative NAD(P) binding site [chemical binding]; other site 699034007153 catalytic Zn binding site [ion binding]; other site 699034007154 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 699034007155 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 699034007156 active site 699034007157 P-loop; other site 699034007158 phosphorylation site [posttranslational modification] 699034007159 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007160 active site 699034007161 phosphorylation site [posttranslational modification] 699034007162 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 699034007163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034007164 Walker A motif; other site 699034007165 ATP binding site [chemical binding]; other site 699034007166 Walker B motif; other site 699034007167 arginine finger; other site 699034007168 PRD domain; Region: PRD; cl15445 699034007169 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 699034007170 active pocket/dimerization site; other site 699034007171 active site 699034007172 phosphorylation site [posttranslational modification] 699034007173 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007174 active site 699034007175 phosphorylation site [posttranslational modification] 699034007176 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 699034007177 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 699034007178 Helix-turn-helix domains; Region: HTH; cl00088 699034007179 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034007180 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 699034007181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034007182 DNA-binding site [nucleotide binding]; DNA binding site 699034007183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007185 homodimer interface [polypeptide binding]; other site 699034007186 catalytic residue [active] 699034007187 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 699034007188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034007189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034007190 dimer interface [polypeptide binding]; other site 699034007191 phosphorylation site [posttranslational modification] 699034007192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034007193 ATP binding site [chemical binding]; other site 699034007194 Mg2+ binding site [ion binding]; other site 699034007195 G-X-G motif; other site 699034007196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034007197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034007198 active site 699034007199 phosphorylation site [posttranslational modification] 699034007200 intermolecular recognition site; other site 699034007201 dimerization interface [polypeptide binding]; other site 699034007202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034007203 DNA binding site [nucleotide binding] 699034007204 Helix-turn-helix domains; Region: HTH; cl00088 699034007205 Helix-turn-helix domains; Region: HTH; cl00088 699034007206 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 699034007207 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 699034007208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034007209 non-specific DNA binding site [nucleotide binding]; other site 699034007210 salt bridge; other site 699034007211 sequence-specific DNA binding site [nucleotide binding]; other site 699034007212 putative transposase OrfB; Reviewed; Region: PHA02517 699034007213 HTH-like domain; Region: HTH_21; pfam13276 699034007214 Integrase core domain; Region: rve; cl01316 699034007215 Integrase core domain; Region: rve_3; cl15866 699034007216 Helix-turn-helix domains; Region: HTH; cl00088 699034007217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 699034007218 Helix-turn-helix domains; Region: HTH; cl00088 699034007219 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 699034007220 DNA-binding site [nucleotide binding]; DNA binding site 699034007221 RNA-binding motif; other site 699034007222 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 699034007223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034007224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034007225 dimer interface [polypeptide binding]; other site 699034007226 conserved gate region; other site 699034007227 putative PBP binding loops; other site 699034007228 ABC-ATPase subunit interface; other site 699034007229 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 699034007230 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 699034007231 Walker A/P-loop; other site 699034007232 ATP binding site [chemical binding]; other site 699034007233 Q-loop/lid; other site 699034007234 ABC transporter signature motif; other site 699034007235 Walker B; other site 699034007236 D-loop; other site 699034007237 H-loop/switch region; other site 699034007238 Domain of unknown function (DUF364); Region: DUF364; pfam04016 699034007239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034007240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034007241 active site 699034007242 phosphorylation site [posttranslational modification] 699034007243 intermolecular recognition site; other site 699034007244 dimerization interface [polypeptide binding]; other site 699034007245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034007246 DNA binding site [nucleotide binding] 699034007247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034007248 dimer interface [polypeptide binding]; other site 699034007249 phosphorylation site [posttranslational modification] 699034007250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034007251 ATP binding site [chemical binding]; other site 699034007252 Mg2+ binding site [ion binding]; other site 699034007253 G-X-G motif; other site 699034007254 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 699034007255 active site 699034007256 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 699034007257 substrate binding site [chemical binding]; other site 699034007258 metal binding site [ion binding]; metal-binding site 699034007259 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 699034007260 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 699034007261 substrate binding site [chemical binding]; other site 699034007262 hexamer interface [polypeptide binding]; other site 699034007263 metal binding site [ion binding]; metal-binding site 699034007264 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 699034007265 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 699034007266 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 699034007267 PYR/PP interface [polypeptide binding]; other site 699034007268 dimer interface [polypeptide binding]; other site 699034007269 TPP binding site [chemical binding]; other site 699034007270 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 699034007271 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 699034007272 TPP-binding site [chemical binding]; other site 699034007273 dimer interface [polypeptide binding]; other site 699034007274 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 699034007275 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 699034007276 putative NAD(P) binding site [chemical binding]; other site 699034007277 catalytic Zn binding site [ion binding]; other site 699034007278 structural Zn binding site [ion binding]; other site 699034007279 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 699034007280 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 699034007281 putative NAD(P) binding site [chemical binding]; other site 699034007282 catalytic Zn binding site [ion binding]; other site 699034007283 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 699034007284 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 699034007285 active site 699034007286 P-loop; other site 699034007287 phosphorylation site [posttranslational modification] 699034007288 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007289 active site 699034007290 phosphorylation site [posttranslational modification] 699034007291 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 699034007292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034007293 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 699034007294 Walker A motif; other site 699034007295 ATP binding site [chemical binding]; other site 699034007296 Walker B motif; other site 699034007297 arginine finger; other site 699034007298 PRD domain; Region: PRD; cl15445 699034007299 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 699034007300 active pocket/dimerization site; other site 699034007301 active site 699034007302 phosphorylation site [posttranslational modification] 699034007303 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007304 active site 699034007305 phosphorylation site [posttranslational modification] 699034007306 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 699034007307 active site 699034007308 intersubunit interactions; other site 699034007309 catalytic residue [active] 699034007310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034007311 active site 699034007312 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 699034007313 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 699034007314 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 699034007315 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007316 active site 699034007317 phosphorylation site [posttranslational modification] 699034007318 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034007319 PRD domain; Region: PRD; cl15445 699034007320 PRD domain; Region: PRD; cl15445 699034007321 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034007322 active site 699034007323 P-loop; other site 699034007324 phosphorylation site [posttranslational modification] 699034007325 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 699034007326 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034007327 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 699034007328 active site 699034007329 P-loop; other site 699034007330 phosphorylation site [posttranslational modification] 699034007331 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 699034007332 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 699034007333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH_2; cd04602 699034007334 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 699034007335 active site 699034007336 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 699034007337 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 699034007338 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 699034007339 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 699034007340 active site 699034007341 NAD binding site [chemical binding]; other site 699034007342 metal binding site [ion binding]; metal-binding site 699034007343 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 699034007344 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 699034007345 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034007346 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 699034007347 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 699034007348 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 699034007349 putative catalytic cysteine [active] 699034007350 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 699034007351 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 699034007352 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034007353 Predicted permease [General function prediction only]; Region: COG2985 699034007354 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 699034007355 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 699034007356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034007357 Helix-turn-helix domains; Region: HTH; cl00088 699034007358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 699034007359 dimerization interface [polypeptide binding]; other site 699034007360 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 699034007361 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 699034007362 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 699034007363 active site 699034007364 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 699034007365 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 699034007366 dimer interface [polypeptide binding]; other site 699034007367 active site 699034007368 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 699034007369 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl06409 699034007370 potential frameshift: common BLAST hit: gi|260687590|ref|YP_003218724.1| glycine/sarcosine/betaine reductase complex protein A 699034007371 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 699034007372 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 699034007373 catalytic residues [active] 699034007374 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 699034007375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034007376 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 699034007377 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 699034007378 active site 699034007379 Zn binding site [ion binding]; other site 699034007380 sugar phosphate phosphatase; Provisional; Region: PRK10513 699034007381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034007382 active site 699034007383 motif I; other site 699034007384 motif II; other site 699034007385 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034007386 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034007387 Alkylmercury lyase; Region: MerB; pfam03243 699034007388 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 699034007389 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 699034007390 Walker A/P-loop; other site 699034007391 ATP binding site [chemical binding]; other site 699034007392 Q-loop/lid; other site 699034007393 ABC transporter signature motif; other site 699034007394 Walker B; other site 699034007395 D-loop; other site 699034007396 H-loop/switch region; other site 699034007397 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 699034007398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034007399 dimer interface [polypeptide binding]; other site 699034007400 conserved gate region; other site 699034007401 ABC-ATPase subunit interface; other site 699034007402 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 699034007403 NMT1-like family; Region: NMT1_2; cl15260 699034007404 Predicted permease; Region: DUF318; pfam03773 699034007405 DsrE/DsrF-like family; Region: DrsE; cl00672 699034007406 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 699034007407 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 699034007408 dimerization interface [polypeptide binding]; other site 699034007409 active site 699034007410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034007411 FAD binding domain; Region: FAD_binding_2; pfam00890 699034007412 Quinolinate synthetase A protein; Region: NadA; cl00420 699034007413 Carbon starvation protein CstA; Region: CstA; pfam02554 699034007414 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 699034007415 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 699034007416 Domain of unknown function DUF20; Region: UPF0118; pfam01594 699034007417 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 699034007418 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 699034007419 nudix motif; other site 699034007420 Predicted membrane protein [Function unknown]; Region: COG2364 699034007421 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034007422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 699034007423 Acetokinase family; Region: Acetate_kinase; cl01029 699034007424 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 699034007425 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 699034007426 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 699034007427 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 699034007428 dimer interface [polypeptide binding]; other site 699034007429 PYR/PP interface [polypeptide binding]; other site 699034007430 TPP binding site [chemical binding]; other site 699034007431 substrate binding site [chemical binding]; other site 699034007432 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 699034007433 TPP-binding site; other site 699034007434 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 699034007435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007437 homodimer interface [polypeptide binding]; other site 699034007438 catalytic residue [active] 699034007439 Propionate catabolism activator; Region: PrpR_N; pfam06506 699034007440 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034007441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 699034007442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034007443 Walker A motif; other site 699034007444 ATP binding site [chemical binding]; other site 699034007445 Walker B motif; other site 699034007446 arginine finger; other site 699034007447 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034007448 metal binding site [ion binding]; metal-binding site 699034007449 active site 699034007450 I-site; other site 699034007451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034007452 metal binding site [ion binding]; metal-binding site 699034007453 active site 699034007454 I-site; other site 699034007455 Protein of unknown function (DUF3785); Region: DUF3785; pfam12653 699034007456 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 699034007457 active site 699034007458 substrate binding site [chemical binding]; other site 699034007459 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 699034007460 FMN binding site [chemical binding]; other site 699034007461 putative catalytic residues [active] 699034007462 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 699034007463 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 699034007464 Helix-turn-helix domains; Region: HTH; cl00088 699034007465 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 699034007466 Helix-turn-helix domains; Region: HTH; cl00088 699034007467 B3/4 domain; Region: B3_4; cl11458 699034007468 Transglycosylase; Region: Transgly; cl07896 699034007469 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 699034007470 active site 699034007471 catalytic site [active] 699034007472 substrate binding site [chemical binding]; other site 699034007473 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 699034007474 MORN repeat; Region: MORN; cl14787 699034007475 MORN repeat; Region: MORN; cl14787 699034007476 Flavin Reductases; Region: FlaRed; cl00801 699034007477 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 699034007478 active site 699034007479 catalytic site [active] 699034007480 substrate binding site [chemical binding]; other site 699034007481 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 699034007482 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 699034007483 Ligand Binding Site [chemical binding]; other site 699034007484 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 699034007485 CotJB protein; Region: CotJB; pfam12652 699034007486 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 699034007487 dinuclear metal binding motif [ion binding]; other site 699034007488 Bacterial SH3 domain; Region: SH3_3; cl02551 699034007489 Bacterial SH3 domain; Region: SH3_3; cl02551 699034007490 Bacterial SH3 domain; Region: SH3_3; cl02551 699034007491 NlpC/P60 family; Region: NLPC_P60; cl11438 699034007492 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 699034007493 trimer interface [polypeptide binding]; other site 699034007494 active site 699034007495 DNA topoisomerase III; Provisional; Region: PRK07726 699034007496 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 699034007497 active site 699034007498 putative interdomain interaction site [polypeptide binding]; other site 699034007499 putative metal-binding site [ion binding]; other site 699034007500 putative nucleotide binding site [chemical binding]; other site 699034007501 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 699034007502 domain I; other site 699034007503 DNA binding groove [nucleotide binding] 699034007504 phosphate binding site [ion binding]; other site 699034007505 domain II; other site 699034007506 domain III; other site 699034007507 nucleotide binding site [chemical binding]; other site 699034007508 catalytic site [active] 699034007509 domain IV; other site 699034007510 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 699034007511 Transcriptional regulators [Transcription]; Region: MarR; COG1846 699034007512 Helix-turn-helix domains; Region: HTH; cl00088 699034007513 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 699034007514 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 699034007515 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 699034007516 Outer membrane efflux protein; Region: OEP; pfam02321 699034007517 HTH-like domain; Region: HTH_21; pfam13276 699034007518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 699034007519 Integrase core domain; Region: rve; cl01316 699034007520 Integrase core domain; Region: rve_3; cl15866 699034007521 Helix-turn-helix domains; Region: HTH; cl00088 699034007522 DNA polymerase II large subunit; Validated; Region: PRK04023 699034007523 pyruvate phosphate dikinase; Provisional; Region: PRK09279 699034007524 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 699034007525 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 699034007526 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 699034007527 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 699034007528 Helix-turn-helix domains; Region: HTH; cl00088 699034007529 FOG: CBS domain [General function prediction only]; Region: COG0517 699034007530 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 699034007531 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 699034007532 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 699034007533 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 699034007534 Glucitol operon activator protein (GutM); Region: GutM; cl01890 699034007535 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034007536 Helix-turn-helix domains; Region: HTH; cl00088 699034007537 Helix-turn-helix domains; Region: HTH; cl00088 699034007538 PRD domain; Region: PRD; cl15445 699034007539 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034007540 active site 699034007541 P-loop; other site 699034007542 phosphorylation site [posttranslational modification] 699034007543 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 699034007544 active site 699034007545 phosphorylation site [posttranslational modification] 699034007546 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 699034007547 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 699034007548 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 699034007549 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 699034007550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034007551 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034007552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034007553 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034007554 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 699034007555 active site 699034007556 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034007557 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 699034007558 metal binding site [ion binding]; metal-binding site 699034007559 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 699034007560 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 699034007561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034007562 putative substrate translocation pore; other site 699034007563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034007564 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 699034007565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007567 homodimer interface [polypeptide binding]; other site 699034007568 catalytic residue [active] 699034007569 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 699034007570 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 699034007571 Acetokinase family; Region: Acetate_kinase; cl01029 699034007572 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 699034007573 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 699034007574 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 699034007575 TPP-binding site [chemical binding]; other site 699034007576 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 699034007577 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 699034007578 dimer interface [polypeptide binding]; other site 699034007579 PYR/PP interface [polypeptide binding]; other site 699034007580 TPP binding site [chemical binding]; other site 699034007581 substrate binding site [chemical binding]; other site 699034007582 hypothetical protein; Provisional; Region: PRK13795 699034007583 4Fe-4S binding domain; Region: Fer4; cl02805 699034007584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 699034007585 Helix-turn-helix domains; Region: HTH; cl00088 699034007586 Bacterial transcriptional regulator; Region: IclR; pfam01614 699034007587 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 699034007588 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 699034007589 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 699034007590 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 699034007591 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 699034007592 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 699034007593 dimer interface [polypeptide binding]; other site 699034007594 motif 1; other site 699034007595 active site 699034007596 motif 2; other site 699034007597 motif 3; other site 699034007598 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 699034007599 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 699034007600 Recombination protein O N terminal; Region: RecO_N; cl15812 699034007601 Recombination protein O C terminal; Region: RecO_C; pfam02565 699034007602 YqzL-like protein; Region: YqzL; pfam14006 699034007603 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 699034007604 MgtE intracellular N domain; Region: MgtE_N; cl15244 699034007605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 699034007606 Divalent cation transporter; Region: MgtE; cl00786 699034007607 GTPase Era; Reviewed; Region: era; PRK00089 699034007608 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 699034007609 G1 box; other site 699034007610 GTP/Mg2+ binding site [chemical binding]; other site 699034007611 Switch I region; other site 699034007612 G2 box; other site 699034007613 Switch II region; other site 699034007614 G3 box; other site 699034007615 G4 box; other site 699034007616 G5 box; other site 699034007617 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 699034007618 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 699034007619 active site 699034007620 catalytic motif [active] 699034007621 Zn binding site [ion binding]; other site 699034007622 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 699034007623 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 699034007624 active site 699034007625 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 699034007626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034007627 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 699034007628 YabP family; Region: YabP; cl06766 699034007629 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 699034007630 30S subunit binding site; other site 699034007631 TspO/MBR family; Region: TspO_MBR; cl01379 699034007632 GatB domain; Region: GatB_Yqey; cl11497 699034007633 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 699034007634 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 699034007635 nucleotide binding site/active site [active] 699034007636 HIT family signature motif; other site 699034007637 catalytic residue [active] 699034007638 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 699034007639 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 699034007640 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034007641 FeS/SAM binding site; other site 699034007642 TRAM domain; Region: TRAM; cl01282 699034007643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 699034007644 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 699034007645 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 699034007646 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 699034007647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034007648 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034007649 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 699034007650 ATP binding site [chemical binding]; other site 699034007651 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 699034007652 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 699034007653 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 699034007654 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 699034007655 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 699034007656 Walker A/P-loop; other site 699034007657 ATP binding site [chemical binding]; other site 699034007658 Q-loop/lid; other site 699034007659 ABC transporter signature motif; other site 699034007660 Walker B; other site 699034007661 D-loop; other site 699034007662 H-loop/switch region; other site 699034007663 TOBE domain; Region: TOBE_2; cl01440 699034007664 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 699034007665 Helix-turn-helix domains; Region: HTH; cl00088 699034007666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034007667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034007668 putative substrate translocation pore; other site 699034007669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034007670 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 699034007671 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034007672 chaperone protein DnaJ; Provisional; Region: PRK14297 699034007673 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 699034007674 HSP70 interaction site [polypeptide binding]; other site 699034007675 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 699034007676 substrate binding site [polypeptide binding]; other site 699034007677 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 699034007678 Zn binding sites [ion binding]; other site 699034007679 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 699034007680 dimer interface [polypeptide binding]; other site 699034007681 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 699034007682 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 699034007683 dimer interface [polypeptide binding]; other site 699034007684 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 699034007685 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 699034007686 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 699034007687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034007688 FeS/SAM binding site; other site 699034007689 HemN C-terminal domain; Region: HemN_C; pfam06969 699034007690 amino acid transporter; Region: 2A0306; TIGR00909 699034007691 Spore germination protein; Region: Spore_permease; cl15802 699034007692 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 699034007693 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 699034007694 active site 699034007695 NTP binding site [chemical binding]; other site 699034007696 metal binding triad [ion binding]; metal-binding site 699034007697 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 699034007698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034007699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034007700 GTP-binding protein LepA; Provisional; Region: PRK05433 699034007701 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 699034007702 G1 box; other site 699034007703 putative GEF interaction site [polypeptide binding]; other site 699034007704 GTP/Mg2+ binding site [chemical binding]; other site 699034007705 Switch I region; other site 699034007706 G2 box; other site 699034007707 G3 box; other site 699034007708 Switch II region; other site 699034007709 G4 box; other site 699034007710 G5 box; other site 699034007711 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 699034007712 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 699034007713 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 699034007714 stage II sporulation protein P; Region: spore_II_P; TIGR02867 699034007715 Germination protease; Region: Peptidase_A25; cl04057 699034007716 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034007717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034007718 dimerization interface [polypeptide binding]; other site 699034007719 putative DNA binding site [nucleotide binding]; other site 699034007720 putative Zn2+ binding site [ion binding]; other site 699034007721 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 699034007722 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 699034007723 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 699034007724 Competence protein; Region: Competence; cl00471 699034007725 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034007726 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 699034007727 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 699034007728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034007729 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 699034007730 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 699034007731 putative ATP binding site [chemical binding]; other site 699034007732 putative substrate interface [chemical binding]; other site 699034007733 Domain of unknown function (DUF348); Region: DUF348; pfam03990 699034007734 G5 domain; Region: G5; pfam07501 699034007735 3D domain; Region: 3D; cl01439 699034007736 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 699034007737 ligand binding site [chemical binding]; other site 699034007738 active site 699034007739 UGI interface [polypeptide binding]; other site 699034007740 catalytic site [active] 699034007741 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 699034007742 trimer interface [polypeptide binding]; other site 699034007743 ApbE family; Region: ApbE; cl00643 699034007744 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 699034007745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007747 homodimer interface [polypeptide binding]; other site 699034007748 catalytic residue [active] 699034007749 aminopeptidase; Provisional; Region: PRK09795 699034007750 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 699034007751 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 699034007752 active site 699034007753 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034007754 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 699034007755 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034007756 active site 699034007757 P-loop; other site 699034007758 phosphorylation site [posttranslational modification] 699034007759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007760 active site 699034007761 phosphorylation site [posttranslational modification] 699034007762 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034007763 Helix-turn-helix domains; Region: HTH; cl00088 699034007764 PRD domain; Region: PRD; cl15445 699034007765 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034007766 active site 699034007767 P-loop; other site 699034007768 phosphorylation site [posttranslational modification] 699034007769 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007770 active site 699034007771 phosphorylation site [posttranslational modification] 699034007772 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 699034007773 dipeptidase PepV; Reviewed; Region: PRK07318 699034007774 active site 699034007775 metal binding site [ion binding]; metal-binding site 699034007776 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 699034007777 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 699034007778 PAS domain S-box; Region: sensory_box; TIGR00229 699034007779 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 699034007780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034007781 dimer interface [polypeptide binding]; other site 699034007782 phosphorylation site [posttranslational modification] 699034007783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034007784 ATP binding site [chemical binding]; other site 699034007785 Mg2+ binding site [ion binding]; other site 699034007786 G-X-G motif; other site 699034007787 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 699034007788 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 699034007789 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034007790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034007791 catalytic residue [active] 699034007792 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 699034007793 dimerization interface [polypeptide binding]; other site 699034007794 putative ATP binding site [chemical binding]; other site 699034007795 SLBB domain; Region: SLBB; pfam10531 699034007796 comEA protein; Region: comE; TIGR01259 699034007797 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 699034007798 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 699034007799 DNA binding site [nucleotide binding] 699034007800 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 699034007801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034007802 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 699034007803 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 699034007804 argininosuccinate lyase; Provisional; Region: PRK00855 699034007805 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 699034007806 active sites [active] 699034007807 tetramer interface [polypeptide binding]; other site 699034007808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034007809 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 699034007810 active site 699034007811 motif I; other site 699034007812 motif II; other site 699034007813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034007814 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 699034007815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007817 homodimer interface [polypeptide binding]; other site 699034007818 catalytic residue [active] 699034007819 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 699034007820 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 699034007821 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034007822 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 699034007823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034007824 motif II; other site 699034007825 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 699034007826 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 699034007827 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 699034007828 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034007829 Helix-turn-helix domains; Region: HTH; cl00088 699034007830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034007831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034007832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034007833 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 699034007834 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 699034007835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034007836 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 699034007837 NAD(P) binding site [chemical binding]; other site 699034007838 LDH/MDH dimer interface [polypeptide binding]; other site 699034007839 substrate binding site [chemical binding]; other site 699034007840 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034007841 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 699034007842 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034007843 active site turn [active] 699034007844 phosphorylation site [posttranslational modification] 699034007845 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034007846 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034007847 PRD domain; Region: PRD; cl15445 699034007848 PRD domain; Region: PRD; cl15445 699034007849 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034007850 HPr interaction site; other site 699034007851 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034007852 active site 699034007853 phosphorylation site [posttranslational modification] 699034007854 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 699034007855 homotrimer interaction site [polypeptide binding]; other site 699034007856 putative active site [active] 699034007857 threonine dehydratase; Provisional; Region: PRK08198 699034007858 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 699034007859 tetramer interface [polypeptide binding]; other site 699034007860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007861 catalytic residue [active] 699034007862 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 699034007863 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 699034007864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034007865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034007866 homodimer interface [polypeptide binding]; other site 699034007867 catalytic residue [active] 699034007868 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 699034007869 active site 699034007870 homotetramer interface [polypeptide binding]; other site 699034007871 homodimer interface [polypeptide binding]; other site 699034007872 VanZ like family; Region: VanZ; cl01971 699034007873 potential frameshift: common BLAST hit: gi|260687757|ref|YP_003218891.1| leucyl-tRNA synthetase 699034007874 Oligomerisation domain; Region: Oligomerisation; cl00519 699034007875 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 699034007876 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034007877 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 699034007878 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 699034007879 active site 699034007880 (T/H)XGH motif; other site 699034007881 RecX family; Region: RecX; cl00936 699034007882 alpha-amylase; Region: PLN02960 699034007883 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 699034007884 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 699034007885 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 699034007886 active site 699034007887 catalytic site [active] 699034007888 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 699034007889 Helix-turn-helix domain; Region: HTH_18; pfam12833 699034007890 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 699034007891 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034007892 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 699034007893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034007894 catalytic residue [active] 699034007895 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034007896 FtsX-like permease family; Region: FtsX; cl15850 699034007897 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034007898 FtsX-like permease family; Region: FtsX; cl15850 699034007899 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034007900 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034007901 Walker A/P-loop; other site 699034007902 ATP binding site [chemical binding]; other site 699034007903 Q-loop/lid; other site 699034007904 ABC transporter signature motif; other site 699034007905 Walker B; other site 699034007906 D-loop; other site 699034007907 H-loop/switch region; other site 699034007908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034007909 dimer interface [polypeptide binding]; other site 699034007910 phosphorylation site [posttranslational modification] 699034007911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034007912 ATP binding site [chemical binding]; other site 699034007913 Mg2+ binding site [ion binding]; other site 699034007914 G-X-G motif; other site 699034007915 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034007916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034007917 active site 699034007918 phosphorylation site [posttranslational modification] 699034007919 intermolecular recognition site; other site 699034007920 dimerization interface [polypeptide binding]; other site 699034007921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034007922 DNA binding site [nucleotide binding] 699034007923 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 699034007924 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 699034007925 putative active site [active] 699034007926 putative metal binding site [ion binding]; other site 699034007927 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 699034007928 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034007929 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 699034007930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034007931 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 699034007932 potential frameshift: common BLAST hit: gi|126700158|ref|YP_001089055.1| sodium:dicarboxylate symporter family protein 699034007933 DHHW protein; Region: DHHW; pfam14286 699034007934 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 699034007935 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 699034007936 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 699034007937 DXD motif; other site 699034007938 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 699034007939 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 699034007940 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 699034007941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034007942 dimer interface [polypeptide binding]; other site 699034007943 conserved gate region; other site 699034007944 putative PBP binding loops; other site 699034007945 ABC-ATPase subunit interface; other site 699034007946 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 699034007947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034007948 dimer interface [polypeptide binding]; other site 699034007949 conserved gate region; other site 699034007950 putative PBP binding loops; other site 699034007951 ABC-ATPase subunit interface; other site 699034007952 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 699034007953 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034007954 hypothetical protein; Provisional; Region: PRK02947 699034007955 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034007956 putative active site [active] 699034007957 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 699034007958 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 699034007959 active site 699034007960 P-loop; other site 699034007961 phosphorylation site [posttranslational modification] 699034007962 Helix-turn-helix domains; Region: HTH; cl00088 699034007963 Helix-turn-helix domains; Region: HTH; cl00088 699034007964 PRD domain; Region: PRD; cl15445 699034007965 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034007966 active site 699034007967 P-loop; other site 699034007968 phosphorylation site [posttranslational modification] 699034007969 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034007970 active site 699034007971 phosphorylation site [posttranslational modification] 699034007972 phosphodiesterase; Provisional; Region: PRK12704 699034007973 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 699034007974 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 699034007975 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 699034007976 active site 699034007977 (T/H)XGH motif; other site 699034007978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034007979 S-adenosylmethionine binding site [chemical binding]; other site 699034007980 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 699034007981 Y-family of DNA polymerases; Region: PolY; cl12025 699034007982 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 699034007983 generic binding surface II; other site 699034007984 ssDNA binding site; other site 699034007985 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034007986 ATP binding site [chemical binding]; other site 699034007987 putative Mg++ binding site [ion binding]; other site 699034007988 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034007989 nucleotide binding region [chemical binding]; other site 699034007990 ATP-binding site [chemical binding]; other site 699034007991 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 699034007992 DAK2 domain; Region: Dak2; cl03685 699034007993 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 699034007994 Asp23 family; Region: Asp23; cl00574 699034007995 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 699034007996 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 699034007997 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 699034007998 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034007999 DNA binding residues [nucleotide binding] 699034008000 dimer interface [polypeptide binding]; other site 699034008001 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 699034008002 Helix-turn-helix domains; Region: HTH; cl00088 699034008003 Helix-turn-helix domains; Region: HTH; cl00088 699034008004 PRD domain; Region: PRD; cl15445 699034008005 PRD domain; Region: PRD; cl15445 699034008006 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034008007 active site 699034008008 P-loop; other site 699034008009 phosphorylation site [posttranslational modification] 699034008010 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034008011 active site 699034008012 phosphorylation site [posttranslational modification] 699034008013 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034008014 active site 699034008015 phosphorylation site [posttranslational modification] 699034008016 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034008017 active site 699034008018 P-loop; other site 699034008019 phosphorylation site [posttranslational modification] 699034008020 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034008021 alpha-mannosidase; Provisional; Region: PRK09819 699034008022 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 699034008023 active site 699034008024 metal binding site [ion binding]; metal-binding site 699034008025 catalytic site [active] 699034008026 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 699034008027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034008028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034008029 dimer interface [polypeptide binding]; other site 699034008030 phosphorylation site [posttranslational modification] 699034008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034008032 ATP binding site [chemical binding]; other site 699034008033 Mg2+ binding site [ion binding]; other site 699034008034 G-X-G motif; other site 699034008035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034008036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034008037 active site 699034008038 phosphorylation site [posttranslational modification] 699034008039 intermolecular recognition site; other site 699034008040 dimerization interface [polypeptide binding]; other site 699034008041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034008042 DNA binding site [nucleotide binding] 699034008043 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 699034008044 putative FMN binding site [chemical binding]; other site 699034008045 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 699034008046 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034008047 Thiamine pyrophosphokinase; Region: TPK; cd07995 699034008048 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 699034008049 active site 699034008050 dimerization interface [polypeptide binding]; other site 699034008051 thiamine binding site [chemical binding]; other site 699034008052 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 699034008053 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 699034008054 substrate binding site [chemical binding]; other site 699034008055 hexamer interface [polypeptide binding]; other site 699034008056 metal binding site [ion binding]; metal-binding site 699034008057 GTPase RsgA; Reviewed; Region: PRK00098 699034008058 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 699034008059 RNA binding site [nucleotide binding]; other site 699034008060 homodimer interface [polypeptide binding]; other site 699034008061 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 699034008062 GTPase/Zn-binding domain interface [polypeptide binding]; other site 699034008063 GTP/Mg2+ binding site [chemical binding]; other site 699034008064 G4 box; other site 699034008065 G5 box; other site 699034008066 G1 box; other site 699034008067 Switch I region; other site 699034008068 G2 box; other site 699034008069 G3 box; other site 699034008070 Switch II region; other site 699034008071 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 699034008072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008073 NAD(P) binding site [chemical binding]; other site 699034008074 active site 699034008075 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 699034008076 Catalytic domain of Protein Kinases; Region: PKc; cd00180 699034008077 active site 699034008078 ATP binding site [chemical binding]; other site 699034008079 substrate binding site [chemical binding]; other site 699034008080 activation loop (A-loop); other site 699034008081 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 699034008082 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 699034008083 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 699034008084 active site 699034008085 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 699034008086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034008087 FeS/SAM binding site; other site 699034008088 16S rRNA methyltransferase B; Provisional; Region: PRK14902 699034008089 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 699034008090 putative RNA binding site [nucleotide binding]; other site 699034008091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034008092 S-adenosylmethionine binding site [chemical binding]; other site 699034008093 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 699034008094 Protein of unknown function DUF116; Region: DUF116; cl00800 699034008095 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 699034008096 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 699034008097 putative active site [active] 699034008098 substrate binding site [chemical binding]; other site 699034008099 putative cosubstrate binding site; other site 699034008100 catalytic site [active] 699034008101 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 699034008102 substrate binding site [chemical binding]; other site 699034008103 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 699034008104 active site 699034008105 catalytic residues [active] 699034008106 metal binding site [ion binding]; metal-binding site 699034008107 primosome assembly protein PriA; Validated; Region: PRK05580 699034008108 primosome assembly protein PriA; Validated; Region: PRK05580 699034008109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034008110 ATP binding site [chemical binding]; other site 699034008111 putative Mg++ binding site [ion binding]; other site 699034008112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034008113 nucleotide binding region [chemical binding]; other site 699034008114 ATP-binding site [chemical binding]; other site 699034008115 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 699034008116 Flavoprotein; Region: Flavoprotein; cl08021 699034008117 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 699034008118 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 699034008119 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 699034008120 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 699034008121 catalytic site [active] 699034008122 G-X2-G-X-G-K; other site 699034008123 hypothetical protein; Provisional; Region: PRK11820 699034008124 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 699034008125 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 699034008126 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 699034008127 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 699034008128 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 699034008129 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 699034008130 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 699034008131 tetramer interface [polypeptide binding]; other site 699034008132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034008133 catalytic residue [active] 699034008134 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 699034008135 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 699034008136 Domain of unknown function (DUF814); Region: DUF814; pfam05670 699034008137 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 699034008138 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034008139 ABC transporter; Region: ABC_tran_2; pfam12848 699034008140 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034008141 uracil transporter; Provisional; Region: PRK10720 699034008142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034008143 active site 699034008144 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 699034008145 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 699034008146 active site 699034008147 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 699034008148 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 699034008149 NodB motif; other site 699034008150 active site 699034008151 catalytic site [active] 699034008152 metal binding site [ion binding]; metal-binding site 699034008153 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 699034008154 Carbon starvation protein CstA; Region: CstA; pfam02554 699034008155 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 699034008156 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 699034008157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034008158 active site 699034008159 phosphorylation site [posttranslational modification] 699034008160 intermolecular recognition site; other site 699034008161 dimerization interface [polypeptide binding]; other site 699034008162 LytTr DNA-binding domain; Region: LytTR; cl04498 699034008163 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 699034008164 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 699034008165 Histidine kinase; Region: His_kinase; pfam06580 699034008166 two-component response regulator; Provisional; Region: PRK14084 699034008167 LytTr DNA-binding domain; Region: LytTR; cl04498 699034008168 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 699034008169 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 699034008170 active site 699034008171 conformational flexibility of ligand binding pocket; other site 699034008172 ADP-ribosylating toxin turn-turn motif; other site 699034008173 PA14 domain; Region: PA14; cl08459 699034008174 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 699034008175 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 699034008176 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 699034008177 active site 699034008178 HIGH motif; other site 699034008179 dimer interface [polypeptide binding]; other site 699034008180 KMSKS motif; other site 699034008181 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 699034008182 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 699034008183 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 699034008184 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 699034008185 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 699034008186 active site 699034008187 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 699034008188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034008189 Helix-turn-helix domains; Region: HTH; cl00088 699034008190 Uncharacterized conserved protein [Function unknown]; Region: COG1284 699034008191 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034008192 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 699034008193 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 699034008194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034008195 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034008196 Probable transposase; Region: OrfB_IS605; pfam01385 699034008197 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034008198 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 699034008199 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 699034008200 active site 699034008201 HIGH motif; other site 699034008202 nucleotide binding site [chemical binding]; other site 699034008203 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 699034008204 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 699034008205 active site 699034008206 KMSKS motif; other site 699034008207 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 699034008208 tRNA binding surface [nucleotide binding]; other site 699034008209 anticodon binding site; other site 699034008210 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 699034008211 DivIVA protein; Region: DivIVA; pfam05103 699034008212 DivIVA domain; Region: DivI1A_domain; TIGR03544 699034008213 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 699034008214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 699034008215 YGGT family; Region: YGGT; cl00508 699034008216 Protein of unknown function (DUF552); Region: DUF552; cl00775 699034008217 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 699034008218 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034008219 catalytic residue [active] 699034008220 HlyD family secretion protein; Region: HlyD_2; pfam12700 699034008221 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 699034008222 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034008223 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 699034008224 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 699034008225 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 699034008226 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 699034008227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034008228 putative substrate translocation pore; other site 699034008229 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 699034008230 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 699034008231 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 699034008232 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 699034008233 active site 699034008234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 699034008235 Helix-turn-helix domains; Region: HTH; cl00088 699034008236 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 699034008237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008238 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 699034008239 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 699034008240 GTP-binding protein Der; Reviewed; Region: PRK00093 699034008241 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 699034008242 G1 box; other site 699034008243 GTP/Mg2+ binding site [chemical binding]; other site 699034008244 Switch I region; other site 699034008245 G2 box; other site 699034008246 Switch II region; other site 699034008247 G3 box; other site 699034008248 G4 box; other site 699034008249 G5 box; other site 699034008250 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 699034008251 G1 box; other site 699034008252 GTP/Mg2+ binding site [chemical binding]; other site 699034008253 Switch I region; other site 699034008254 G2 box; other site 699034008255 G3 box; other site 699034008256 Switch II region; other site 699034008257 G4 box; other site 699034008258 G5 box; other site 699034008259 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 699034008260 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 699034008261 Protein of unknown function (DUF512); Region: DUF512; pfam04459 699034008262 YIEGIA protein; Region: YIEGIA; pfam14045 699034008263 YIEGIA protein; Region: YIEGIA; pfam14045 699034008264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 699034008265 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 699034008266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 699034008267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034008268 dimer interface [polypeptide binding]; other site 699034008269 phosphorylation site [posttranslational modification] 699034008270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034008271 ATP binding site [chemical binding]; other site 699034008272 Mg2+ binding site [ion binding]; other site 699034008273 G-X-G motif; other site 699034008274 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 699034008275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034008276 active site 699034008277 phosphorylation site [posttranslational modification] 699034008278 intermolecular recognition site; other site 699034008279 dimerization interface [polypeptide binding]; other site 699034008280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034008281 DNA binding site [nucleotide binding] 699034008282 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 699034008283 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 699034008284 ATP cone domain; Region: ATP-cone; pfam03477 699034008285 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 699034008286 sporulation sigma factor SigG; Reviewed; Region: PRK08215 699034008287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034008288 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 699034008289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034008290 DNA binding residues [nucleotide binding] 699034008291 sporulation sigma factor SigE; Reviewed; Region: PRK08301 699034008292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034008293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034008294 DNA binding residues [nucleotide binding] 699034008295 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 699034008296 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 699034008297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 699034008298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034008299 cell division protein FtsZ; Region: ftsZ; TIGR00065 699034008300 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 699034008301 nucleotide binding site [chemical binding]; other site 699034008302 SulA interaction site; other site 699034008303 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 699034008304 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 699034008305 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 699034008306 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 699034008307 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 699034008308 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 699034008309 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 699034008310 active site 699034008311 homodimer interface [polypeptide binding]; other site 699034008312 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 699034008313 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 699034008314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 699034008315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 699034008316 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 699034008317 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 699034008318 Mg++ binding site [ion binding]; other site 699034008319 putative catalytic motif [active] 699034008320 putative substrate binding site [chemical binding]; other site 699034008321 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 699034008322 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 699034008323 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 699034008324 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 699034008325 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 699034008326 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 699034008327 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034008328 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 699034008329 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 699034008330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034008331 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 699034008332 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 699034008333 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 699034008334 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 699034008335 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 699034008336 GTP-binding protein YchF; Reviewed; Region: PRK09601 699034008337 YchF GTPase; Region: YchF; cd01900 699034008338 G1 box; other site 699034008339 GTP/Mg2+ binding site [chemical binding]; other site 699034008340 Switch I region; other site 699034008341 G2 box; other site 699034008342 Switch II region; other site 699034008343 G3 box; other site 699034008344 G4 box; other site 699034008345 G5 box; other site 699034008346 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 699034008347 Cache domain; Region: Cache_1; pfam02743 699034008348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034008349 metal binding site [ion binding]; metal-binding site 699034008350 active site 699034008351 I-site; other site 699034008352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034008353 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 699034008354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 699034008355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 699034008356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 699034008357 Cupin domain; Region: Cupin_2; cl09118 699034008358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034008359 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034008360 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 699034008361 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034008362 active site turn [active] 699034008363 phosphorylation site [posttranslational modification] 699034008364 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034008365 HPr interaction site; other site 699034008366 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034008367 active site 699034008368 phosphorylation site [posttranslational modification] 699034008369 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034008370 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034008371 PRD domain; Region: PRD; cl15445 699034008372 PRD domain; Region: PRD; cl15445 699034008373 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 699034008374 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 699034008375 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 699034008376 Walker A/P-loop; other site 699034008377 ATP binding site [chemical binding]; other site 699034008378 Q-loop/lid; other site 699034008379 ABC transporter signature motif; other site 699034008380 Walker B; other site 699034008381 D-loop; other site 699034008382 H-loop/switch region; other site 699034008383 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 699034008384 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 699034008385 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 699034008386 Walker A/P-loop; other site 699034008387 ATP binding site [chemical binding]; other site 699034008388 Q-loop/lid; other site 699034008389 ABC transporter signature motif; other site 699034008390 Walker B; other site 699034008391 D-loop; other site 699034008392 H-loop/switch region; other site 699034008393 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 699034008394 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 699034008395 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 699034008396 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 699034008397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034008398 dimer interface [polypeptide binding]; other site 699034008399 conserved gate region; other site 699034008400 putative PBP binding loops; other site 699034008401 ABC-ATPase subunit interface; other site 699034008402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034008403 dimer interface [polypeptide binding]; other site 699034008404 conserved gate region; other site 699034008405 putative PBP binding loops; other site 699034008406 ABC-ATPase subunit interface; other site 699034008407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034008408 Helix-turn-helix domains; Region: HTH; cl00088 699034008409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 699034008410 dimerization interface [polypeptide binding]; other site 699034008411 putative acyltransferase; Provisional; Region: PRK05790 699034008412 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 699034008413 dimer interface [polypeptide binding]; other site 699034008414 active site 699034008415 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034008416 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034008417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008418 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 699034008419 NAD(P) binding site [chemical binding]; other site 699034008420 active site 699034008421 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 699034008422 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 699034008423 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 699034008424 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 699034008425 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 699034008426 dimer interface [polypeptide binding]; other site 699034008427 PYR/PP interface [polypeptide binding]; other site 699034008428 TPP binding site [chemical binding]; other site 699034008429 substrate binding site [chemical binding]; other site 699034008430 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 699034008431 Domain of unknown function; Region: EKR; cl11037 699034008432 4Fe-4S binding domain; Region: Fer4; cl02805 699034008433 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 699034008434 TPP-binding site [chemical binding]; other site 699034008435 dimer interface [polypeptide binding]; other site 699034008436 Propanediol utilisation protein PduL; Region: PduL; pfam06130 699034008437 Propanediol utilisation protein PduL; Region: PduL; pfam06130 699034008438 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034008439 GAF domain; Region: GAF; cl15785 699034008440 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 699034008441 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 699034008442 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 699034008443 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 699034008444 HI0933-like protein; Region: HI0933_like; pfam03486 699034008445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008446 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 699034008447 active site 699034008448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034008449 active site 699034008450 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 699034008451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034008452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034008453 homodimer interface [polypeptide binding]; other site 699034008454 catalytic residue [active] 699034008455 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 699034008456 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 699034008457 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 699034008458 dimer interface [polypeptide binding]; other site 699034008459 active site 699034008460 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 699034008461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034008462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034008463 homodimer interface [polypeptide binding]; other site 699034008464 catalytic residue [active] 699034008465 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 699034008466 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034008467 metal binding site [ion binding]; metal-binding site 699034008468 putative dimer interface [polypeptide binding]; other site 699034008469 Nucleoside recognition; Region: Gate; cl00486 699034008470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 699034008471 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034008472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034008473 Walker A motif; other site 699034008474 ATP binding site [chemical binding]; other site 699034008475 Walker B motif; other site 699034008476 arginine finger; other site 699034008477 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 699034008478 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 699034008479 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 699034008480 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 699034008481 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 699034008482 Sulfate transporter family; Region: Sulfate_transp; cl15842 699034008483 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 699034008484 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 699034008485 active site 699034008486 putative substrate binding pocket [chemical binding]; other site 699034008487 HIRAN domain; Region: HIRAN; cl07418 699034008488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034008489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 699034008490 putative substrate translocation pore; other site 699034008491 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 699034008492 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 699034008493 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 699034008494 shikimate binding site; other site 699034008495 NAD(P) binding site [chemical binding]; other site 699034008496 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 699034008497 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 699034008498 active site 699034008499 FMN binding site [chemical binding]; other site 699034008500 substrate binding site [chemical binding]; other site 699034008501 putative catalytic residue [active] 699034008502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008503 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034008504 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 699034008505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034008506 Helix-turn-helix domains; Region: HTH; cl00088 699034008507 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 699034008508 putative dimerization interface [polypeptide binding]; other site 699034008509 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 699034008510 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 699034008511 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 699034008512 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 699034008513 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 699034008514 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 699034008515 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008516 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008517 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008518 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 699034008519 UDP-glucose 4-epimerase; Region: PLN02240 699034008520 NAD binding site [chemical binding]; other site 699034008521 homodimer interface [polypeptide binding]; other site 699034008522 active site 699034008523 substrate binding site [chemical binding]; other site 699034008524 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 699034008525 active site 699034008526 catalytic site [active] 699034008527 potential RNA of insufficient length (23S ribosomal RNA) 699034008528 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 699034008529 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 699034008530 NodB motif; other site 699034008531 active site 699034008532 catalytic site [active] 699034008533 Cd binding site [ion binding]; other site 699034008534 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 699034008535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 699034008536 dimerization interface [polypeptide binding]; other site 699034008537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034008538 dimer interface [polypeptide binding]; other site 699034008539 phosphorylation site [posttranslational modification] 699034008540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034008541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034008542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034008543 active site 699034008544 phosphorylation site [posttranslational modification] 699034008545 intermolecular recognition site; other site 699034008546 dimerization interface [polypeptide binding]; other site 699034008547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034008548 DNA binding site [nucleotide binding] 699034008549 Predicted integral membrane protein [Function unknown]; Region: COG0392 699034008550 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 699034008551 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 699034008552 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 699034008553 NodB motif; other site 699034008554 putative active site [active] 699034008555 putative catalytic site [active] 699034008556 putative Zn binding site [ion binding]; other site 699034008557 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 699034008558 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 699034008559 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 699034008560 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 699034008561 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 699034008562 dimer interface [polypeptide binding]; other site 699034008563 active site 699034008564 glycine-pyridoxal phosphate binding site [chemical binding]; other site 699034008565 folate binding site [chemical binding]; other site 699034008566 Uncharacterized conserved protein [Function unknown]; Region: COG2966 699034008567 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 699034008568 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 699034008569 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 699034008570 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 699034008571 putative homodimer interface [polypeptide binding]; other site 699034008572 putative homotetramer interface [polypeptide binding]; other site 699034008573 putative allosteric switch controlling residues; other site 699034008574 putative metal binding site [ion binding]; other site 699034008575 putative homodimer-homodimer interface [polypeptide binding]; other site 699034008576 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034008577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034008578 Walker A motif; other site 699034008579 ATP binding site [chemical binding]; other site 699034008580 Walker B motif; other site 699034008581 arginine finger; other site 699034008582 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 699034008583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034008584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034008585 homodimer interface [polypeptide binding]; other site 699034008586 catalytic residue [active] 699034008587 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 699034008588 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008589 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008590 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008591 Bacterial SH3 domain; Region: SH3_3; cl02551 699034008592 Bacterial SH3 domain; Region: SH3_3; cl02551 699034008593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034008594 Helix-turn-helix domains; Region: HTH; cl00088 699034008595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 699034008596 dimerization interface [polypeptide binding]; other site 699034008597 Predicted amidohydrolase [General function prediction only]; Region: COG0388 699034008598 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_6; cd07584 699034008599 putative active site [active] 699034008600 catalytic triad [active] 699034008601 putative dimer interface [polypeptide binding]; other site 699034008602 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 699034008603 Na binding site [ion binding]; other site 699034008604 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 699034008605 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 699034008606 dimer interface [polypeptide binding]; other site 699034008607 anticodon binding site; other site 699034008608 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 699034008609 homodimer interface [polypeptide binding]; other site 699034008610 motif 1; other site 699034008611 active site 699034008612 motif 2; other site 699034008613 GAD domain; Region: GAD; pfam02938 699034008614 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 699034008615 active site 699034008616 motif 3; other site 699034008617 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 699034008618 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 699034008619 dimer interface [polypeptide binding]; other site 699034008620 motif 1; other site 699034008621 active site 699034008622 motif 2; other site 699034008623 motif 3; other site 699034008624 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 699034008625 anticodon binding site; other site 699034008626 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 699034008627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034008628 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 699034008629 putative active site [active] 699034008630 dimerization interface [polypeptide binding]; other site 699034008631 putative tRNAtyr binding site [nucleotide binding]; other site 699034008632 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 699034008633 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 699034008634 Zn2+ binding site [ion binding]; other site 699034008635 Mg2+ binding site [ion binding]; other site 699034008636 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 699034008637 synthetase active site [active] 699034008638 NTP binding site [chemical binding]; other site 699034008639 metal binding site [ion binding]; metal-binding site 699034008640 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 699034008641 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 699034008642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034008643 active site 699034008644 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 699034008645 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 699034008646 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 699034008647 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 699034008648 trimer interface [polypeptide binding]; other site 699034008649 putative metal binding site [ion binding]; other site 699034008650 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 699034008651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 699034008652 FeS/SAM binding site; other site 699034008653 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 699034008654 Staphylococcal AgrD protein; Region: AgrD; cl05477 699034008655 Accessory gene regulator B; Region: AgrB; cl01873 699034008656 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034008657 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034008658 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034008659 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034008660 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034008661 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 699034008662 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 699034008663 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 699034008664 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 699034008665 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 699034008666 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 699034008667 dimerization domain swap beta strand [polypeptide binding]; other site 699034008668 regulatory protein interface [polypeptide binding]; other site 699034008669 active site 699034008670 regulatory phosphorylation site [posttranslational modification]; other site 699034008671 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 699034008672 active site 699034008673 nucleophile elbow; other site 699034008674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034008675 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 699034008676 Helix-turn-helix domains; Region: HTH; cl00088 699034008677 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034008678 active site 699034008679 metal binding site [ion binding]; metal-binding site 699034008680 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 699034008681 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 699034008682 catalytic residue [active] 699034008683 putative FPP diphosphate binding site; other site 699034008684 putative FPP binding hydrophobic cleft; other site 699034008685 dimer interface [polypeptide binding]; other site 699034008686 putative IPP diphosphate binding site; other site 699034008687 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 699034008688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034008689 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 699034008690 active site 699034008691 motif I; other site 699034008692 motif II; other site 699034008693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034008694 motif I; other site 699034008695 motif II; other site 699034008696 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034008697 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 699034008698 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 699034008699 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 699034008700 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008701 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008702 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008703 Bacterial SH3 domain; Region: SH3_3; cl02551 699034008704 NlpC/P60 family; Region: NLPC_P60; cl11438 699034008705 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 699034008706 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 699034008707 NAD(P) binding site [chemical binding]; other site 699034008708 homodimer interface [polypeptide binding]; other site 699034008709 substrate binding site [chemical binding]; other site 699034008710 active site 699034008711 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 699034008712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 699034008713 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 699034008714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008715 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 699034008716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008717 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 699034008718 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 699034008719 active site 699034008720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 699034008721 active site 699034008722 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 699034008723 active site 699034008724 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 699034008725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 699034008726 active site 699034008727 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 699034008728 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 699034008729 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 699034008730 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 699034008731 active site 699034008732 substrate binding site [chemical binding]; other site 699034008733 metal binding site [ion binding]; metal-binding site 699034008734 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 699034008735 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008736 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008737 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008738 Bacterial sugar transferase; Region: Bac_transf; cl00939 699034008739 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008740 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008741 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008742 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 699034008743 active site 699034008744 metal binding site [ion binding]; metal-binding site 699034008745 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008746 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008747 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008748 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 699034008749 active site 699034008750 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008751 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008752 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008753 GtrA-like protein; Region: GtrA; cl00971 699034008754 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008755 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008756 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008757 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 699034008758 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008759 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008760 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 699034008761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034008762 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 699034008763 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034008764 nucleotide binding region [chemical binding]; other site 699034008765 ATP-binding site [chemical binding]; other site 699034008766 Low molecular weight S layer protein N terminal; Region: LMWSLP_N; pfam12211 699034008767 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008768 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008769 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008770 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008771 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008772 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 699034008773 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 699034008774 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008775 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008776 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008777 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 699034008778 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 699034008779 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008780 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008781 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008782 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 699034008783 Interdomain contacts; other site 699034008784 Cytokine receptor motif; other site 699034008785 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 699034008786 Peptidase M60-like family; Region: M60-like; pfam13402 699034008787 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 699034008788 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008789 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008790 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008791 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 699034008792 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008793 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008794 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034008795 Protein of unknown function (DUF4001); Region: DUF4001; cl14848 699034008796 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 699034008797 Preprotein translocase subunit; Region: YajC; cl00806 699034008798 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 699034008799 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 699034008800 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 699034008801 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 699034008802 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 699034008803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034008804 Walker A motif; other site 699034008805 ATP binding site [chemical binding]; other site 699034008806 Walker B motif; other site 699034008807 arginine finger; other site 699034008808 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 699034008809 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 699034008810 RuvA N terminal domain; Region: RuvA_N; pfam01330 699034008811 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 699034008812 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 699034008813 active site 699034008814 putative DNA-binding cleft [nucleotide binding]; other site 699034008815 dimer interface [polypeptide binding]; other site 699034008816 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 699034008817 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 699034008818 Predicted membrane protein [Function unknown]; Region: COG4905 699034008819 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 699034008820 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 699034008821 GntP family permease; Region: GntP_permease; pfam02447 699034008822 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 699034008823 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 699034008824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034008826 DNA-binding site [nucleotide binding]; DNA binding site 699034008827 FCD domain; Region: FCD; cl11656 699034008828 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 699034008829 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034008830 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034008831 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 699034008832 Walker A/P-loop; other site 699034008833 ATP binding site [chemical binding]; other site 699034008834 Q-loop/lid; other site 699034008835 ABC transporter signature motif; other site 699034008836 Walker B; other site 699034008837 D-loop; other site 699034008838 H-loop/switch region; other site 699034008839 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 699034008840 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 699034008841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034008842 Walker A/P-loop; other site 699034008843 ATP binding site [chemical binding]; other site 699034008844 Q-loop/lid; other site 699034008845 ABC transporter signature motif; other site 699034008846 Walker B; other site 699034008847 D-loop; other site 699034008848 H-loop/switch region; other site 699034008849 potential frameshift: common BLAST hit: gi|308175184|ref|YP_003921889.1| oxidoreductase 699034008850 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 699034008851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 699034008852 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034008853 catalytic residue [active] 699034008854 HTH-like domain; Region: HTH_21; pfam13276 699034008855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 699034008856 Integrase core domain; Region: rve; cl01316 699034008857 Integrase core domain; Region: rve_3; cl15866 699034008858 Helix-turn-helix domains; Region: HTH; cl00088 699034008859 Nucleoside recognition; Region: Gate; cl00486 699034008860 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 699034008861 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 699034008862 metal binding site [ion binding]; metal-binding site 699034008863 dimer interface [polypeptide binding]; other site 699034008864 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 699034008865 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034008866 DNA binding residues [nucleotide binding] 699034008867 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034008868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034008869 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034008870 Probable transposase; Region: OrfB_IS605; pfam01385 699034008871 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034008872 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 699034008873 active site 699034008874 FMN binding site [chemical binding]; other site 699034008875 substrate binding site [chemical binding]; other site 699034008876 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034008877 Helix-turn-helix domains; Region: HTH; cl00088 699034008878 aspartate aminotransferase; Provisional; Region: PRK06836 699034008879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034008880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034008881 homodimer interface [polypeptide binding]; other site 699034008882 catalytic residue [active] 699034008883 EamA-like transporter family; Region: EamA; cl01037 699034008884 EamA-like transporter family; Region: EamA; cl01037 699034008885 hypothetical protein; Provisional; Region: PHA03169 699034008886 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 699034008887 Collagen binding domain; Region: Collagen_bind; pfam05737 699034008888 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 699034008889 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 699034008890 Cation efflux family; Region: Cation_efflux; cl00316 699034008891 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 699034008892 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 699034008893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 699034008894 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 699034008895 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 699034008896 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034008897 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 699034008898 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 699034008899 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 699034008900 dimer interface [polypeptide binding]; other site 699034008901 active site 699034008902 glycine-pyridoxal phosphate binding site [chemical binding]; other site 699034008903 folate binding site [chemical binding]; other site 699034008904 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 699034008905 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034008906 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 699034008907 metal binding site [ion binding]; metal-binding site 699034008908 dimer interface [polypeptide binding]; other site 699034008909 Uncharacterized membrane protein [Function unknown]; Region: COG3949 699034008910 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 699034008911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034008912 Response regulator receiver domain; Region: Response_reg; pfam00072 699034008913 active site 699034008914 phosphorylation site [posttranslational modification] 699034008915 intermolecular recognition site; other site 699034008916 dimerization interface [polypeptide binding]; other site 699034008917 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034008918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034008919 Cupin domain; Region: Cupin_2; cl09118 699034008920 Histidine kinase; Region: His_kinase; pfam06580 699034008921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034008922 seryl-tRNA synthetase; Provisional; Region: PRK05431 699034008923 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 699034008924 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 699034008925 dimer interface [polypeptide binding]; other site 699034008926 active site 699034008927 motif 1; other site 699034008928 motif 2; other site 699034008929 motif 3; other site 699034008930 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 699034008931 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 699034008932 active site 699034008933 Predicted amidohydrolase [General function prediction only]; Region: COG0388 699034008934 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 699034008935 putative active site [active] 699034008936 catalytic triad [active] 699034008937 putative dimer interface [polypeptide binding]; other site 699034008938 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 699034008939 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 699034008940 NADP binding site [chemical binding]; other site 699034008941 dimer interface [polypeptide binding]; other site 699034008942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034008943 Helix-turn-helix domains; Region: HTH; cl00088 699034008944 Helix-turn-helix domains; Region: HTH; cl00088 699034008945 Rubrerythrin [Energy production and conversion]; Region: COG1592 699034008946 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 699034008947 binuclear metal center [ion binding]; other site 699034008948 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 699034008949 iron binding site [ion binding]; other site 699034008950 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 699034008951 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 699034008952 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 699034008953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034008954 motif II; other site 699034008955 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 699034008956 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034008957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034008958 catalytic residue [active] 699034008959 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 699034008960 Helix-turn-helix domains; Region: HTH; cl00088 699034008961 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 699034008962 Phosphopantetheine attachment site; Region: PP-binding; cl09936 699034008963 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 699034008964 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 699034008965 AMP-binding enzyme; Region: AMP-binding; cl15778 699034008966 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 699034008967 DltD central region; Region: DltD_M; pfam04918 699034008968 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 699034008969 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 699034008970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034008971 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 699034008972 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 699034008973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034008974 motif II; other site 699034008975 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 699034008976 Domain of unknown function DUF21; Region: DUF21; pfam01595 699034008977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 699034008978 Transporter associated domain; Region: CorC_HlyC; cl08393 699034008979 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 699034008980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034008981 active site 699034008982 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034008983 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 699034008984 active site 699034008985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 699034008986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034008987 Walker A motif; other site 699034008988 ATP binding site [chemical binding]; other site 699034008989 Walker B motif; other site 699034008990 arginine finger; other site 699034008991 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034008992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034008993 Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908 699034008994 Ferritin-like domain; Region: Ferritin; pfam00210 699034008995 dinuclear metal binding motif [ion binding]; other site 699034008996 FtsX-like permease family; Region: FtsX; cl15850 699034008997 FtsX-like permease family; Region: FtsX; cl15850 699034008998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034008999 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034009000 Walker A/P-loop; other site 699034009001 ATP binding site [chemical binding]; other site 699034009002 Q-loop/lid; other site 699034009003 ABC transporter signature motif; other site 699034009004 Walker B; other site 699034009005 D-loop; other site 699034009006 H-loop/switch region; other site 699034009007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034009008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034009009 ATP binding site [chemical binding]; other site 699034009010 Mg2+ binding site [ion binding]; other site 699034009011 G-X-G motif; other site 699034009012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034009013 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 699034009014 active site 699034009015 phosphorylation site [posttranslational modification] 699034009016 intermolecular recognition site; other site 699034009017 dimerization interface [polypeptide binding]; other site 699034009018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034009019 DNA binding site [nucleotide binding] 699034009020 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 699034009021 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 699034009022 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 699034009023 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 699034009024 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 699034009025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034009026 Propionate catabolism activator; Region: PrpR_N; pfam06506 699034009027 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034009028 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 699034009029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034009030 Walker A motif; other site 699034009031 ATP binding site [chemical binding]; other site 699034009032 Walker B motif; other site 699034009033 arginine finger; other site 699034009034 Helix-turn-helix domains; Region: HTH; cl00088 699034009035 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 699034009036 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 699034009037 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 699034009038 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 699034009039 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034009040 active site 699034009041 I-site; other site 699034009042 metal binding site [ion binding]; metal-binding site 699034009043 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034009044 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 699034009045 MatE; Region: MatE; cl10513 699034009046 MatE; Region: MatE; cl10513 699034009047 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 699034009048 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 699034009049 Walker A/P-loop; other site 699034009050 ATP binding site [chemical binding]; other site 699034009051 Q-loop/lid; other site 699034009052 ABC transporter signature motif; other site 699034009053 Walker B; other site 699034009054 D-loop; other site 699034009055 H-loop/switch region; other site 699034009056 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 699034009057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 699034009058 ABC-ATPase subunit interface; other site 699034009059 dimer interface [polypeptide binding]; other site 699034009060 putative PBP binding regions; other site 699034009061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 699034009062 ABC-ATPase subunit interface; other site 699034009063 dimer interface [polypeptide binding]; other site 699034009064 putative PBP binding regions; other site 699034009065 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 699034009066 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 699034009067 putative ligand binding residues [chemical binding]; other site 699034009068 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 699034009069 methionine cluster; other site 699034009070 active site 699034009071 phosphorylation site [posttranslational modification] 699034009072 metal binding site [ion binding]; metal-binding site 699034009073 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 699034009074 putative active site [active] 699034009075 YdjC motif; other site 699034009076 Mg binding site [ion binding]; other site 699034009077 putative homodimer interface [polypeptide binding]; other site 699034009078 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 699034009079 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 699034009080 NAD binding site [chemical binding]; other site 699034009081 sugar binding site [chemical binding]; other site 699034009082 divalent metal binding site [ion binding]; other site 699034009083 tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034009084 dimer interface [polypeptide binding]; other site 699034009085 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 699034009086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009087 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034009088 active site 699034009089 P-loop; other site 699034009090 phosphorylation site [posttranslational modification] 699034009091 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 699034009092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034009093 DNA-binding site [nucleotide binding]; DNA binding site 699034009094 UTRA domain; Region: UTRA; cl01230 699034009095 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 699034009096 MatE; Region: MatE; cl10513 699034009097 MatE; Region: MatE; cl10513 699034009098 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034009099 metal binding site [ion binding]; metal-binding site 699034009100 active site 699034009101 I-site; other site 699034009102 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 699034009103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034009104 dimer interface [polypeptide binding]; other site 699034009105 conserved gate region; other site 699034009106 putative PBP binding loops; other site 699034009107 ABC-ATPase subunit interface; other site 699034009108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034009109 dimer interface [polypeptide binding]; other site 699034009110 conserved gate region; other site 699034009111 putative PBP binding loops; other site 699034009112 ABC-ATPase subunit interface; other site 699034009113 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 699034009114 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034009115 Walker A/P-loop; other site 699034009116 ATP binding site [chemical binding]; other site 699034009117 Q-loop/lid; other site 699034009118 ABC transporter signature motif; other site 699034009119 Walker B; other site 699034009120 D-loop; other site 699034009121 H-loop/switch region; other site 699034009122 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 699034009123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034009124 ATP synthase subunit D; Region: ATP-synt_D; cl00613 699034009125 V-type ATP synthase subunit B; Provisional; Region: PRK04196 699034009126 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 699034009127 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 699034009128 Walker A motif homologous position; other site 699034009129 Walker B motif; other site 699034009130 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 699034009131 V-type ATP synthase subunit A; Provisional; Region: PRK04192 699034009132 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 699034009133 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 699034009134 Walker A motif/ATP binding site; other site 699034009135 Walker B motif; other site 699034009136 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 699034009137 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 699034009138 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 699034009139 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 699034009140 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 699034009141 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 699034009142 V-type ATP synthase subunit K; Validated; Region: PRK06558 699034009143 ATP synthase subunit C; Region: ATP-synt_C; cl00466 699034009144 V-type ATP synthase subunit I; Validated; Region: PRK05771 699034009145 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 699034009146 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 699034009147 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 699034009148 B3/4 domain; Region: B3_4; cl11458 699034009149 Cache domain; Region: Cache_1; pfam02743 699034009150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034009151 metal binding site [ion binding]; metal-binding site 699034009152 active site 699034009153 I-site; other site 699034009154 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034009155 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 699034009156 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 699034009157 putative catalytic cysteine [active] 699034009158 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 699034009159 putative active site [active] 699034009160 metal binding site [ion binding]; metal-binding site 699034009161 Flavoprotein; Region: Flavoprotein; cl08021 699034009162 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 699034009163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034009164 NAD(P) binding pocket [chemical binding]; other site 699034009165 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 699034009166 AMP-binding enzyme; Region: AMP-binding; cl15778 699034009167 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 699034009168 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 699034009169 dimer interface [polypeptide binding]; other site 699034009170 active site 699034009171 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 699034009172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 699034009173 Coenzyme A binding pocket [chemical binding]; other site 699034009174 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 699034009175 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 699034009176 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 699034009177 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 699034009178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034009179 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 699034009180 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 699034009181 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-B; cd09658 699034009182 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 699034009183 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 699034009184 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 699034009185 Helix-turn-helix domains; Region: HTH; cl00088 699034009186 Predicted transcriptional regulator [Transcription]; Region: COG2378 699034009187 WYL domain; Region: WYL; cl14852 699034009188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034009189 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034009190 Walker A/P-loop; other site 699034009191 ATP binding site [chemical binding]; other site 699034009192 Q-loop/lid; other site 699034009193 ABC transporter signature motif; other site 699034009194 Walker B; other site 699034009195 D-loop; other site 699034009196 H-loop/switch region; other site 699034009197 Bacitracin resistance protein BacA; Region: BacA; cl00858 699034009198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 699034009199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034009200 ATP binding site [chemical binding]; other site 699034009201 Mg2+ binding site [ion binding]; other site 699034009202 G-X-G motif; other site 699034009203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034009204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034009205 active site 699034009206 phosphorylation site [posttranslational modification] 699034009207 intermolecular recognition site; other site 699034009208 dimerization interface [polypeptide binding]; other site 699034009209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034009210 DNA binding site [nucleotide binding] 699034009211 NMT1-like family; Region: NMT1_2; cl15260 699034009212 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 699034009213 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 699034009214 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 699034009215 Walker A/P-loop; other site 699034009216 ATP binding site [chemical binding]; other site 699034009217 Q-loop/lid; other site 699034009218 ABC transporter signature motif; other site 699034009219 Walker B; other site 699034009220 D-loop; other site 699034009221 H-loop/switch region; other site 699034009222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034009223 dimer interface [polypeptide binding]; other site 699034009224 conserved gate region; other site 699034009225 putative PBP binding loops; other site 699034009226 ABC-ATPase subunit interface; other site 699034009227 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034009228 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 699034009229 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 699034009230 dimer interface [polypeptide binding]; other site 699034009231 putative radical transfer pathway; other site 699034009232 diiron center [ion binding]; other site 699034009233 tyrosyl radical; other site 699034009234 ribonucleoside-diphosphate reductase, class 1b, alpha subunit; Region: RNR_1b_NrdE; TIGR04170 699034009235 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 699034009236 Class I ribonucleotide reductase; Region: RNR_I; cd01679 699034009237 active site 699034009238 dimer interface [polypeptide binding]; other site 699034009239 catalytic residues [active] 699034009240 effector binding site; other site 699034009241 R2 peptide binding site; other site 699034009242 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 699034009243 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 699034009244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 699034009245 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 699034009246 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 699034009247 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 699034009248 Walker A/P-loop; other site 699034009249 ATP binding site [chemical binding]; other site 699034009250 Q-loop/lid; other site 699034009251 ABC transporter signature motif; other site 699034009252 Walker B; other site 699034009253 D-loop; other site 699034009254 H-loop/switch region; other site 699034009255 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 699034009256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034009257 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034009258 Probable transposase; Region: OrfB_IS605; pfam01385 699034009259 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034009260 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034009261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 699034009262 ABC-ATPase subunit interface; other site 699034009263 dimer interface [polypeptide binding]; other site 699034009264 putative PBP binding regions; other site 699034009265 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 699034009266 putative ligand binding site [chemical binding]; other site 699034009267 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 699034009268 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 699034009269 inhibitor site; inhibition site 699034009270 active site 699034009271 dimer interface [polypeptide binding]; other site 699034009272 catalytic residue [active] 699034009273 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 699034009274 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 699034009275 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 699034009276 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 699034009277 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 699034009278 Transcriptional regulator [Transcription]; Region: IclR; COG1414 699034009279 Helix-turn-helix domains; Region: HTH; cl00088 699034009280 Bacterial transcriptional regulator; Region: IclR; pfam01614 699034009281 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 699034009282 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 699034009283 dimer interface [polypeptide binding]; other site 699034009284 active site 699034009285 metal binding site [ion binding]; metal-binding site 699034009286 Bacterial SH3 domain; Region: SH3_3; cl02551 699034009287 Bacterial SH3 domain; Region: SH3_3; cl02551 699034009288 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 699034009289 Protein of unknown function (DUF434); Region: DUF434; cl04460 699034009290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034009291 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 699034009292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034009293 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 699034009294 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 699034009295 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 699034009296 catalytic residues [active] 699034009297 Helix-turn-helix domains; Region: HTH; cl00088 699034009298 alpha-mannosidase; Provisional; Region: PRK09819 699034009299 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 699034009300 active site 699034009301 metal binding site [ion binding]; metal-binding site 699034009302 catalytic site [active] 699034009303 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 699034009304 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009305 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034009306 active site 699034009307 P-loop; other site 699034009308 phosphorylation site [posttranslational modification] 699034009309 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009310 active site 699034009311 phosphorylation site [posttranslational modification] 699034009312 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034009313 Helix-turn-helix domains; Region: HTH; cl00088 699034009314 Helix-turn-helix domains; Region: HTH; cl00088 699034009315 PRD domain; Region: PRD; cl15445 699034009316 PRD domain; Region: PRD; cl15445 699034009317 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034009318 active site 699034009319 P-loop; other site 699034009320 phosphorylation site [posttranslational modification] 699034009321 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009322 active site 699034009323 phosphorylation site [posttranslational modification] 699034009324 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 699034009325 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 699034009326 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 699034009327 gating phenylalanine in ion channel; other site 699034009328 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 699034009329 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 699034009330 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 699034009331 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 699034009332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034009333 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 699034009334 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034009335 HPr interaction site; other site 699034009336 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034009337 active site 699034009338 phosphorylation site [posttranslational modification] 699034009339 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 699034009340 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 699034009341 putative active site [active] 699034009342 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 699034009343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034009344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034009345 homodimer interface [polypeptide binding]; other site 699034009346 catalytic residue [active] 699034009347 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 699034009348 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009349 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009350 active site turn [active] 699034009351 phosphorylation site [posttranslational modification] 699034009352 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034009353 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034009354 PRD domain; Region: PRD; cl15445 699034009355 PRD domain; Region: PRD; cl15445 699034009356 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 699034009357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034009358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034009359 catalytic residue [active] 699034009360 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 699034009361 catalytic residues [active] 699034009362 Helix-turn-helix domains; Region: HTH; cl00088 699034009363 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 699034009364 C-terminal domain interface [polypeptide binding]; other site 699034009365 sugar binding site [chemical binding]; other site 699034009366 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 699034009367 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 699034009368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034009369 putative substrate translocation pore; other site 699034009370 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 699034009371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 699034009372 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 699034009373 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 699034009374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034009375 Walker A motif; other site 699034009376 ATP binding site [chemical binding]; other site 699034009377 Walker B motif; other site 699034009378 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 699034009379 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 699034009380 Predicted membrane protein [Function unknown]; Region: COG4129 699034009381 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 699034009382 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 699034009383 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 699034009384 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034009385 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034009386 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034009387 putative active site [active] 699034009388 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 699034009389 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034009390 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 699034009391 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 699034009392 putative active site [active] 699034009393 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 699034009394 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034009395 active site 699034009396 P-loop; other site 699034009397 phosphorylation site [posttranslational modification] 699034009398 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 699034009399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034009400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034009401 ATP binding site [chemical binding]; other site 699034009402 Mg2+ binding site [ion binding]; other site 699034009403 G-X-G motif; other site 699034009404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034009405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034009406 active site 699034009407 phosphorylation site [posttranslational modification] 699034009408 intermolecular recognition site; other site 699034009409 dimerization interface [polypeptide binding]; other site 699034009410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034009411 DNA binding site [nucleotide binding] 699034009412 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034009413 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034009414 Walker A/P-loop; other site 699034009415 ATP binding site [chemical binding]; other site 699034009416 Q-loop/lid; other site 699034009417 ABC transporter signature motif; other site 699034009418 Walker B; other site 699034009419 D-loop; other site 699034009420 H-loop/switch region; other site 699034009421 oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882 699034009422 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034009423 HPr interaction site; other site 699034009424 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034009425 active site 699034009426 phosphorylation site [posttranslational modification] 699034009427 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 699034009428 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 699034009429 NAD binding site [chemical binding]; other site 699034009430 sugar binding site [chemical binding]; other site 699034009431 divalent metal binding site [ion binding]; other site 699034009432 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034009433 dimer interface [polypeptide binding]; other site 699034009434 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 699034009435 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009436 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009437 active site turn [active] 699034009438 phosphorylation site [posttranslational modification] 699034009439 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034009440 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034009441 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034009442 putative active site [active] 699034009443 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 699034009444 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 699034009445 N- and C-terminal domain interface [polypeptide binding]; other site 699034009446 D-xylulose kinase; Region: XylB; TIGR01312 699034009447 active site 699034009448 catalytic site [active] 699034009449 metal binding site [ion binding]; metal-binding site 699034009450 xylulose binding site [chemical binding]; other site 699034009451 putative ATP binding site [chemical binding]; other site 699034009452 homodimer interface [polypeptide binding]; other site 699034009453 Helix-turn-helix domains; Region: HTH; cl00088 699034009454 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 699034009455 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 699034009456 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 699034009457 active pocket/dimerization site; other site 699034009458 active site 699034009459 phosphorylation site [posttranslational modification] 699034009460 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 699034009461 active site 699034009462 phosphorylation site [posttranslational modification] 699034009463 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 699034009464 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 699034009465 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 699034009466 putative active site [active] 699034009467 putative catalytic site [active] 699034009468 Protein of unknown function (DUF523); Region: DUF523; cl00733 699034009469 Protein of unknown function DUF262; Region: DUF262; cl14890 699034009470 Protein of unknown function DUF262; Region: DUF262; cl14890 699034009471 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 699034009472 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 699034009473 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 699034009474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034009475 ATP binding site [chemical binding]; other site 699034009476 putative Mg++ binding site [ion binding]; other site 699034009477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034009478 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 699034009479 active site 699034009480 NTP binding site [chemical binding]; other site 699034009481 metal binding triad [ion binding]; metal-binding site 699034009482 antibiotic binding site [chemical binding]; other site 699034009483 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 699034009484 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 699034009485 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 699034009486 HsdM N-terminal domain; Region: HsdM_N; pfam12161 699034009487 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 699034009488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034009489 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 699034009490 hypothetical protein; Provisional; Region: PRK08185 699034009491 intersubunit interface [polypeptide binding]; other site 699034009492 active site 699034009493 zinc binding site [ion binding]; other site 699034009494 Na+ binding site [ion binding]; other site 699034009495 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 699034009496 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034009497 active site 699034009498 P-loop; other site 699034009499 phosphorylation site [posttranslational modification] 699034009500 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009501 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009502 active site 699034009503 phosphorylation site [posttranslational modification] 699034009504 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 699034009505 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 699034009506 putative substrate binding site [chemical binding]; other site 699034009507 putative ATP binding site [chemical binding]; other site 699034009508 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034009509 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034009510 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034009511 putative active site [active] 699034009512 Predicted membrane protein [Function unknown]; Region: COG2364 699034009513 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034009514 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 699034009515 active site 699034009516 methionine cluster; other site 699034009517 phosphorylation site [posttranslational modification] 699034009518 metal binding site [ion binding]; metal-binding site 699034009519 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009520 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034009521 Helix-turn-helix domains; Region: HTH; cl00088 699034009522 Helix-turn-helix domains; Region: HTH; cl00088 699034009523 PRD domain; Region: PRD; cl15445 699034009524 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034009525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009526 active site 699034009527 phosphorylation site [posttranslational modification] 699034009528 Glycerate kinase family; Region: Gly_kinase; cl00841 699034009529 alpha-mannosidase; Provisional; Region: PRK09819 699034009530 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 699034009531 active site 699034009532 metal binding site [ion binding]; metal-binding site 699034009533 catalytic site [active] 699034009534 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 699034009535 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 699034009536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009537 active site 699034009538 phosphorylation site [posttranslational modification] 699034009539 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034009540 active site 699034009541 P-loop; other site 699034009542 phosphorylation site [posttranslational modification] 699034009543 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009544 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 699034009545 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 699034009546 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 699034009547 putative active site [active] 699034009548 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 699034009549 putative active site [active] 699034009550 YdjC motif; other site 699034009551 Mg binding site [ion binding]; other site 699034009552 putative homodimer interface [polypeptide binding]; other site 699034009553 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009554 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 699034009555 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009556 active site turn [active] 699034009557 phosphorylation site [posttranslational modification] 699034009558 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 699034009559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034009560 DNA-binding site [nucleotide binding]; DNA binding site 699034009561 UTRA domain; Region: UTRA; cl01230 699034009562 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 699034009563 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 699034009564 Ca binding site [ion binding]; other site 699034009565 active site 699034009566 catalytic site [active] 699034009567 amino acid transporter; Region: 2A0306; TIGR00909 699034009568 Spore germination protein; Region: Spore_permease; cl15802 699034009569 Peptidase C26; Region: Peptidase_C26; pfam07722 699034009570 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 699034009571 catalytic triad [active] 699034009572 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034009573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034009574 Walker A motif; other site 699034009575 ATP binding site [chemical binding]; other site 699034009576 Walker B motif; other site 699034009577 arginine finger; other site 699034009578 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034009579 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 699034009580 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009581 active site turn [active] 699034009582 phosphorylation site [posttranslational modification] 699034009583 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009584 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 699034009585 HPr interaction site; other site 699034009586 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034009587 active site 699034009588 phosphorylation site [posttranslational modification] 699034009589 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034009590 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034009591 PRD domain; Region: PRD; cl15445 699034009592 PRD domain; Region: PRD; cl15445 699034009593 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 699034009594 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034009595 metal binding site [ion binding]; metal-binding site 699034009596 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 699034009597 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 699034009598 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009599 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009600 active site turn [active] 699034009601 phosphorylation site [posttranslational modification] 699034009602 dipeptidase PepV; Reviewed; Region: PRK07318 699034009603 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 699034009604 active site 699034009605 metal binding site [ion binding]; metal-binding site 699034009606 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034009607 HPr interaction site; other site 699034009608 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034009609 active site 699034009610 phosphorylation site [posttranslational modification] 699034009611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034009612 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 699034009613 active site 699034009614 motif I; other site 699034009615 motif II; other site 699034009616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034009617 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034009618 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 699034009619 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 699034009620 active site 699034009621 NAD binding site [chemical binding]; other site 699034009622 metal binding site [ion binding]; metal-binding site 699034009623 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 699034009624 catalytic residue [active] 699034009625 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034009626 Helix-turn-helix domains; Region: HTH; cl00088 699034009627 Helix-turn-helix domains; Region: HTH; cl00088 699034009628 PRD domain; Region: PRD; cl15445 699034009629 PRD domain; Region: PRD; cl15445 699034009630 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034009631 active site 699034009632 P-loop; other site 699034009633 phosphorylation site [posttranslational modification] 699034009634 Uncharacterized conserved protein [Function unknown]; Region: COG1284 699034009635 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 699034009636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 699034009637 phosphate binding site [ion binding]; other site 699034009638 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 699034009639 active site 699034009640 ADP/pyrophosphate binding site [chemical binding]; other site 699034009641 dimerization interface [polypeptide binding]; other site 699034009642 allosteric effector site; other site 699034009643 fructose-1,6-bisphosphate binding site; other site 699034009644 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034009645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034009646 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034009647 Probable transposase; Region: OrfB_IS605; pfam01385 699034009648 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034009649 Predicted transcriptional regulator [Transcription]; Region: COG3355 699034009650 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034009651 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 699034009652 metal binding site [ion binding]; metal-binding site 699034009653 dimer interface [polypeptide binding]; other site 699034009654 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 699034009655 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034009656 putative metal binding site [ion binding]; other site 699034009657 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034009658 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 699034009659 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009660 active site turn [active] 699034009661 phosphorylation site [posttranslational modification] 699034009662 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009663 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034009664 HPr interaction site; other site 699034009665 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034009666 active site 699034009667 phosphorylation site [posttranslational modification] 699034009668 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034009669 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034009670 PRD domain; Region: PRD; cl15445 699034009671 PRD domain; Region: PRD; cl15445 699034009672 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 699034009673 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 699034009674 glycosyltransferase, MGT family; Region: MGT; TIGR01426 699034009675 active site 699034009676 TDP-binding site; other site 699034009677 acceptor substrate-binding pocket; other site 699034009678 homodimer interface [polypeptide binding]; other site 699034009679 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 699034009680 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 699034009681 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 699034009682 putative catalytic residues [active] 699034009683 catalytic nucleophile [active] 699034009684 Recombinase; Region: Recombinase; pfam07508 699034009685 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 699034009686 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 699034009687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034009688 non-specific DNA binding site [nucleotide binding]; other site 699034009689 salt bridge; other site 699034009690 sequence-specific DNA binding site [nucleotide binding]; other site 699034009691 Replication initiation factor; Region: Rep_trans; pfam02486 699034009692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034009693 non-specific DNA binding site [nucleotide binding]; other site 699034009694 salt bridge; other site 699034009695 sequence-specific DNA binding site [nucleotide binding]; other site 699034009696 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 699034009697 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 699034009698 active site 699034009699 FMN binding site [chemical binding]; other site 699034009700 substrate binding site [chemical binding]; other site 699034009701 putative catalytic residue [active] 699034009702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034009703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 699034009704 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 699034009705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034009706 putative substrate translocation pore; other site 699034009707 Helix-turn-helix domains; Region: HTH; cl00088 699034009708 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 699034009709 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034009710 4Fe-4S binding domain; Region: Fer4; cl02805 699034009711 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 699034009712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034009713 dimerization interface [polypeptide binding]; other site 699034009714 putative DNA binding site [nucleotide binding]; other site 699034009715 putative Zn2+ binding site [ion binding]; other site 699034009716 4Fe-4S binding domain; Region: Fer4; cl02805 699034009717 ferredoxin; Validated; Region: PRK07118 699034009718 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034009719 FMN binding site [chemical binding]; other site 699034009720 dimer interface [polypeptide binding]; other site 699034009721 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034009722 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 699034009723 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009724 active site turn [active] 699034009725 phosphorylation site [posttranslational modification] 699034009726 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009727 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 699034009728 HPr interaction site; other site 699034009729 glycerol kinase (GK) interaction site [polypeptide binding]; other site 699034009730 active site 699034009731 phosphorylation site [posttranslational modification] 699034009732 CAT RNA binding domain; Region: CAT_RBD; cl03904 699034009733 transcriptional antiterminator BglG; Provisional; Region: PRK09772 699034009734 PRD domain; Region: PRD; cl15445 699034009735 PRD domain; Region: PRD; cl15445 699034009736 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 699034009737 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 699034009738 active site turn [active] 699034009739 phosphorylation site [posttranslational modification] 699034009740 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009741 beta-phosphoglucomutase; Region: bPGM; TIGR01990 699034009742 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034009743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034009744 motif II; other site 699034009745 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 699034009746 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 699034009747 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 699034009748 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 699034009749 Cupin domain; Region: Cupin_2; cl09118 699034009750 DNA polymerase III PolC; Validated; Region: polC; PRK00448 699034009751 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 699034009752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034009753 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009754 active site 699034009755 phosphorylation site [posttranslational modification] 699034009756 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034009757 Helix-turn-helix domains; Region: HTH; cl00088 699034009758 Helix-turn-helix domains; Region: HTH; cl00088 699034009759 PRD domain; Region: PRD; cl15445 699034009760 PRD domain; Region: PRD; cl15445 699034009761 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034009762 active site 699034009763 P-loop; other site 699034009764 phosphorylation site [posttranslational modification] 699034009765 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 699034009766 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034009767 active site 699034009768 phosphorylation site [posttranslational modification] 699034009769 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 699034009770 active site 699034009771 P-loop; other site 699034009772 phosphorylation site [posttranslational modification] 699034009773 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034009774 hypothetical protein; Provisional; Region: PRK08185 699034009775 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 699034009776 intersubunit interface [polypeptide binding]; other site 699034009777 active site 699034009778 zinc binding site [ion binding]; other site 699034009779 Na+ binding site [ion binding]; other site 699034009780 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 699034009781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034009782 dimer interface [polypeptide binding]; other site 699034009783 conserved gate region; other site 699034009784 putative PBP binding loops; other site 699034009785 ABC-ATPase subunit interface; other site 699034009786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034009787 dimer interface [polypeptide binding]; other site 699034009788 conserved gate region; other site 699034009789 putative PBP binding loops; other site 699034009790 ABC-ATPase subunit interface; other site 699034009791 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 699034009792 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034009793 Walker A/P-loop; other site 699034009794 ATP binding site [chemical binding]; other site 699034009795 Q-loop/lid; other site 699034009796 ABC transporter signature motif; other site 699034009797 Walker B; other site 699034009798 D-loop; other site 699034009799 H-loop/switch region; other site 699034009800 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 699034009801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034009802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034009803 sequence-specific DNA binding site [nucleotide binding]; other site 699034009804 salt bridge; other site 699034009805 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 699034009806 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 699034009807 conserved cys residue [active] 699034009808 Predicted transcriptional regulator [Transcription]; Region: COG2378 699034009809 Helix-turn-helix domains; Region: HTH; cl00088 699034009810 WYL domain; Region: WYL; cl14852 699034009811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034009812 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 699034009813 'potential frameshift: common BLAST hit: gi|260686438|ref|YP_003217571.1| integrase, catalytic region' 699034009814 Protein of unknown function DUF262; Region: DUF262; cl14890 699034009815 FRG domain; Region: FRG; cl07460 699034009816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034009817 DDE superfamily endonuclease; Region: DDE_4; cl15789 699034009818 DDE superfamily endonuclease; Region: DDE_4; cl15789 699034009819 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034009820 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034009821 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 699034009822 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 699034009823 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 699034009824 potential frameshift: common BLAST hit: gi|260688339|ref|YP_003219473.1| CRISPR-associated protein cas5 family 699034009825 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 699034009826 active site 699034009827 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 699034009828 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 699034009829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034009830 Walker A motif; other site 699034009831 ATP binding site [chemical binding]; other site 699034009832 Walker B motif; other site 699034009833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034009834 non-specific DNA binding site [nucleotide binding]; other site 699034009835 salt bridge; other site 699034009836 sequence-specific DNA binding site [nucleotide binding]; other site 699034009837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 699034009838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034009839 non-specific DNA binding site [nucleotide binding]; other site 699034009840 salt bridge; other site 699034009841 sequence-specific DNA binding site [nucleotide binding]; other site 699034009842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034009843 non-specific DNA binding site [nucleotide binding]; other site 699034009844 salt bridge; other site 699034009845 sequence-specific DNA binding site [nucleotide binding]; other site 699034009846 Fic family protein [Function unknown]; Region: COG3177 699034009847 Fic/DOC family; Region: Fic; cl00960 699034009848 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 699034009849 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 699034009850 Int/Topo IB signature motif; other site 699034009851 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 699034009852 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 699034009853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 699034009854 P63C domain; Region: P63C; pfam10546 699034009855 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 699034009856 SmpB-tmRNA interface; other site 699034009857 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 699034009858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 699034009859 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034009860 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 699034009861 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 699034009862 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034009863 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 699034009864 Walker A/P-loop; other site 699034009865 ATP binding site [chemical binding]; other site 699034009866 Q-loop/lid; other site 699034009867 ABC transporter signature motif; other site 699034009868 Walker B; other site 699034009869 D-loop; other site 699034009870 H-loop/switch region; other site 699034009871 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 699034009872 ribonuclease R; Region: RNase_R; TIGR02063 699034009873 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034009874 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034009875 RNB domain; Region: RNB; pfam00773 699034009876 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 699034009877 RNA binding site [nucleotide binding]; other site 699034009878 A new structural DNA glycosylase; Region: AlkD_like; cl11434 699034009879 HEAT repeats; Region: HEAT_2; pfam13646 699034009880 active site 699034009881 Helix-turn-helix domains; Region: HTH; cl00088 699034009882 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 699034009883 substrate binding site [chemical binding]; other site 699034009884 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 699034009885 dimer interface [polypeptide binding]; other site 699034009886 metal binding site [ion binding]; metal-binding site 699034009887 Membrane transport protein; Region: Mem_trans; cl09117 699034009888 Preprotein translocase SecG subunit; Region: SecG; cl09123 699034009889 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034009890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034009891 Helix-turn-helix domains; Region: HTH; cl00088 699034009892 enolase; Provisional; Region: eno; PRK00077 699034009893 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 699034009894 dimer interface [polypeptide binding]; other site 699034009895 metal binding site [ion binding]; metal-binding site 699034009896 substrate binding pocket [chemical binding]; other site 699034009897 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 699034009898 Sulfatase; Region: Sulfatase; cl10460 699034009899 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 699034009900 substrate binding site [chemical binding]; other site 699034009901 dimer interface [polypeptide binding]; other site 699034009902 catalytic triad [active] 699034009903 Phosphoglycerate kinase; Region: PGK; pfam00162 699034009904 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 699034009905 substrate binding site [chemical binding]; other site 699034009906 hinge regions; other site 699034009907 ADP binding site [chemical binding]; other site 699034009908 catalytic site [active] 699034009909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034009910 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 699034009911 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 699034009912 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 699034009913 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 699034009914 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 699034009915 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 699034009916 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 699034009917 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 699034009918 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 699034009919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 699034009920 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 699034009921 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 699034009922 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 699034009923 phenylhydantoinase; Validated; Region: PRK08323 699034009924 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 699034009925 tetramer interface [polypeptide binding]; other site 699034009926 active site 699034009927 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 699034009928 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 699034009929 active site 699034009930 FMN binding site [chemical binding]; other site 699034009931 substrate binding site [chemical binding]; other site 699034009932 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 699034009933 4Fe-4S binding domain; Region: Fer4; cl02805 699034009934 xanthine permease; Region: pbuX; TIGR03173 699034009935 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 699034009936 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 699034009937 active site 699034009938 putative substrate binding pocket [chemical binding]; other site 699034009939 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 699034009940 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 699034009941 active site 699034009942 putative substrate binding pocket [chemical binding]; other site 699034009943 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034009944 peptidase; Reviewed; Region: PRK13004 699034009945 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 699034009946 putative metal binding site [ion binding]; other site 699034009947 putative dimer interface [polypeptide binding]; other site 699034009948 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 699034009949 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 699034009950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034009951 catalytic residue [active] 699034009952 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 699034009953 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034009954 GAF domain; Region: GAF; cl15785 699034009955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034009956 Walker A motif; other site 699034009957 ATP binding site [chemical binding]; other site 699034009958 Walker B motif; other site 699034009959 arginine finger; other site 699034009960 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 699034009961 homotrimer interaction site [polypeptide binding]; other site 699034009962 putative active site [active] 699034009963 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034009964 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 699034009965 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 699034009966 DNA binding residues [nucleotide binding] 699034009967 putative dimer interface [polypeptide binding]; other site 699034009968 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 699034009969 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 699034009970 active site 699034009971 catalytic tetrad [active] 699034009972 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 699034009973 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034009974 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034009975 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 699034009976 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 699034009977 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 699034009978 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034009979 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034009980 Walker A/P-loop; other site 699034009981 ATP binding site [chemical binding]; other site 699034009982 Q-loop/lid; other site 699034009983 ABC transporter signature motif; other site 699034009984 Walker B; other site 699034009985 D-loop; other site 699034009986 H-loop/switch region; other site 699034009987 FtsX-like permease family; Region: FtsX; cl15850 699034009988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 699034009989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034009990 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 699034009991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034009992 active site 699034009993 phosphorylation site [posttranslational modification] 699034009994 intermolecular recognition site; other site 699034009995 dimerization interface [polypeptide binding]; other site 699034009996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 699034009997 DNA binding residues [nucleotide binding] 699034009998 dimerization interface [polypeptide binding]; other site 699034009999 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 699034010000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034010001 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034010002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034010003 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034010004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010005 Walker A/P-loop; other site 699034010006 ATP binding site [chemical binding]; other site 699034010007 Q-loop/lid; other site 699034010008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010009 ABC transporter signature motif; other site 699034010010 Walker B; other site 699034010011 D-loop; other site 699034010012 H-loop/switch region; other site 699034010013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010014 Walker A/P-loop; other site 699034010015 ATP binding site [chemical binding]; other site 699034010016 Q-loop/lid; other site 699034010017 ABC transporter signature motif; other site 699034010018 Walker B; other site 699034010019 D-loop; other site 699034010020 H-loop/switch region; other site 699034010021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 699034010022 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 699034010023 DNA binding residues [nucleotide binding] 699034010024 putative dimer interface [polypeptide binding]; other site 699034010025 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 699034010026 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034010027 DNA binding residues [nucleotide binding] 699034010028 dimer interface [polypeptide binding]; other site 699034010029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034010030 H+ Antiporter protein; Region: 2A0121; TIGR00900 699034010031 putative substrate translocation pore; other site 699034010032 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 699034010033 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 699034010034 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034010035 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034010036 Walker A/P-loop; other site 699034010037 ATP binding site [chemical binding]; other site 699034010038 Q-loop/lid; other site 699034010039 ABC transporter signature motif; other site 699034010040 Walker B; other site 699034010041 D-loop; other site 699034010042 H-loop/switch region; other site 699034010043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 699034010044 dimerization interface [polypeptide binding]; other site 699034010045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034010046 dimer interface [polypeptide binding]; other site 699034010047 phosphorylation site [posttranslational modification] 699034010048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034010049 ATP binding site [chemical binding]; other site 699034010050 Mg2+ binding site [ion binding]; other site 699034010051 G-X-G motif; other site 699034010052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034010053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010054 active site 699034010055 phosphorylation site [posttranslational modification] 699034010056 intermolecular recognition site; other site 699034010057 dimerization interface [polypeptide binding]; other site 699034010058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034010059 DNA binding site [nucleotide binding] 699034010060 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 699034010061 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 699034010062 putative FMN binding site [chemical binding]; other site 699034010063 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 699034010064 MatE; Region: MatE; cl10513 699034010065 MatE; Region: MatE; cl10513 699034010066 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 699034010067 Helix-turn-helix domains; Region: HTH; cl00088 699034010068 Helix-turn-helix domains; Region: HTH; cl00088 699034010069 Helix-turn-helix domains; Region: HTH; cl00088 699034010070 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034010071 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034010072 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 699034010073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034010074 S-adenosylmethionine binding site [chemical binding]; other site 699034010075 Protein of unknown function (DUF3781); Region: DUF3781; pfam12636 699034010076 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 699034010077 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034010078 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 699034010079 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010080 Walker A/P-loop; other site 699034010081 ATP binding site [chemical binding]; other site 699034010082 Q-loop/lid; other site 699034010083 ABC transporter signature motif; other site 699034010084 Walker B; other site 699034010085 D-loop; other site 699034010086 H-loop/switch region; other site 699034010087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034010088 dimer interface [polypeptide binding]; other site 699034010089 conserved gate region; other site 699034010090 putative PBP binding loops; other site 699034010091 ABC-ATPase subunit interface; other site 699034010092 NMT1-like family; Region: NMT1_2; cl15260 699034010093 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 699034010094 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010095 Walker A/P-loop; other site 699034010096 ATP binding site [chemical binding]; other site 699034010097 Q-loop/lid; other site 699034010098 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034010099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010100 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 699034010101 Walker A/P-loop; other site 699034010102 ATP binding site [chemical binding]; other site 699034010103 Q-loop/lid; other site 699034010104 ABC transporter signature motif; other site 699034010105 Walker B; other site 699034010106 D-loop; other site 699034010107 H-loop/switch region; other site 699034010108 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 699034010109 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 699034010110 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 699034010111 dimerization interface [polypeptide binding]; other site 699034010112 domain crossover interface; other site 699034010113 redox-dependent activation switch; other site 699034010114 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 699034010115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034010116 S-adenosylmethionine binding site [chemical binding]; other site 699034010117 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 699034010118 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 699034010119 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 699034010120 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 699034010121 metal binding site [ion binding]; metal-binding site 699034010122 dimer interface [polypeptide binding]; other site 699034010123 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 699034010124 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 699034010125 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 699034010126 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 699034010127 dihydrodipicolinate synthase; Region: dapA; TIGR00674 699034010128 dimer interface [polypeptide binding]; other site 699034010129 active site 699034010130 catalytic residue [active] 699034010131 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 699034010132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010133 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 699034010134 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 699034010135 dihydrodipicolinate synthase; Region: dapA; TIGR00674 699034010136 dimer interface [polypeptide binding]; other site 699034010137 active site 699034010138 catalytic residue [active] 699034010139 dihydrodipicolinate reductase; Provisional; Region: PRK00048 699034010140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010141 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 699034010142 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 699034010143 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 699034010144 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 699034010145 active site 699034010146 trimer interface [polypeptide binding]; other site 699034010147 substrate binding site [chemical binding]; other site 699034010148 CoA binding site [chemical binding]; other site 699034010149 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 699034010150 putative CoA binding site [chemical binding]; other site 699034010151 putative trimer interface [polypeptide binding]; other site 699034010152 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 699034010153 dihydrodipicolinate reductase; Provisional; Region: PRK00048 699034010154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010155 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 699034010156 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034010157 active site 699034010158 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 699034010159 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 699034010160 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 699034010161 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034010162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034010163 Walker A motif; other site 699034010164 ATP binding site [chemical binding]; other site 699034010165 Walker B motif; other site 699034010166 arginine finger; other site 699034010167 Helix-turn-helix domains; Region: HTH; cl00088 699034010168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034010169 single-stranded DNA-binding protein; Provisional; Region: PRK05813 699034010170 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 699034010171 dimer interface [polypeptide binding]; other site 699034010172 ssDNA binding site [nucleotide binding]; other site 699034010173 tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034010174 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 699034010175 proline racemase; Provisional; Region: PRK13969 699034010176 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 699034010177 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 699034010178 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 699034010179 potential frameshift: common BLAST hit: gi|260688442|ref|YP_003219576.1| proline reductase 699034010180 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 699034010181 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 699034010182 FOG: CBS domain [General function prediction only]; Region: COG0517 699034010183 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_13; cd04626 699034010184 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 699034010185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034010186 Walker A motif; other site 699034010187 ATP binding site [chemical binding]; other site 699034010188 Walker B motif; other site 699034010189 arginine finger; other site 699034010190 Helix-turn-helix domains; Region: HTH; cl00088 699034010191 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 699034010192 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 699034010193 SLBB domain; Region: SLBB; pfam10531 699034010194 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 699034010195 NodB motif; other site 699034010196 active site 699034010197 catalytic site [active] 699034010198 metal binding site [ion binding]; metal-binding site 699034010199 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 699034010200 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 699034010201 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 699034010202 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 699034010203 TSCPD domain; Region: TSCPD; cl14834 699034010204 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 699034010205 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 699034010206 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 699034010207 active site 699034010208 catalytic triad [active] 699034010209 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 699034010210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010211 active site 699034010212 phosphorylation site [posttranslational modification] 699034010213 intermolecular recognition site; other site 699034010214 dimerization interface [polypeptide binding]; other site 699034010215 LytTr DNA-binding domain; Region: LytTR; cl04498 699034010216 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 699034010217 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 699034010218 active site 699034010219 HIGH motif; other site 699034010220 nucleotide binding site [chemical binding]; other site 699034010221 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 699034010222 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 699034010223 active site 699034010224 KMSKS motif; other site 699034010225 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 699034010226 tRNA binding surface [nucleotide binding]; other site 699034010227 anticodon binding site; other site 699034010228 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 699034010229 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 699034010230 NodB motif; other site 699034010231 active site 699034010232 catalytic site [active] 699034010233 Zn binding site [ion binding]; other site 699034010234 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 699034010235 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 699034010236 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 699034010237 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 699034010238 PhoU domain; Region: PhoU; pfam01895 699034010239 PhoU domain; Region: PhoU; pfam01895 699034010240 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 699034010241 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 699034010242 Walker A/P-loop; other site 699034010243 ATP binding site [chemical binding]; other site 699034010244 Q-loop/lid; other site 699034010245 ABC transporter signature motif; other site 699034010246 Walker B; other site 699034010247 D-loop; other site 699034010248 H-loop/switch region; other site 699034010249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034010250 dimer interface [polypeptide binding]; other site 699034010251 conserved gate region; other site 699034010252 putative PBP binding loops; other site 699034010253 ABC-ATPase subunit interface; other site 699034010254 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 699034010255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034010256 dimer interface [polypeptide binding]; other site 699034010257 conserved gate region; other site 699034010258 putative PBP binding loops; other site 699034010259 ABC-ATPase subunit interface; other site 699034010260 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034010261 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 699034010262 Walker A/P-loop; other site 699034010263 ATP binding site [chemical binding]; other site 699034010264 Q-loop/lid; other site 699034010265 ABC transporter signature motif; other site 699034010266 Walker B; other site 699034010267 D-loop; other site 699034010268 H-loop/switch region; other site 699034010269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 699034010270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034010271 dimer interface [polypeptide binding]; other site 699034010272 phosphorylation site [posttranslational modification] 699034010273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034010274 ATP binding site [chemical binding]; other site 699034010275 Mg2+ binding site [ion binding]; other site 699034010276 G-X-G motif; other site 699034010277 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034010278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010279 active site 699034010280 phosphorylation site [posttranslational modification] 699034010281 intermolecular recognition site; other site 699034010282 dimerization interface [polypeptide binding]; other site 699034010283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034010284 DNA binding site [nucleotide binding] 699034010285 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034010286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010287 active site 699034010288 phosphorylation site [posttranslational modification] 699034010289 intermolecular recognition site; other site 699034010290 dimerization interface [polypeptide binding]; other site 699034010291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034010292 DNA binding site [nucleotide binding] 699034010293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 699034010294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034010295 dimer interface [polypeptide binding]; other site 699034010296 phosphorylation site [posttranslational modification] 699034010297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034010298 ATP binding site [chemical binding]; other site 699034010299 Mg2+ binding site [ion binding]; other site 699034010300 G-X-G motif; other site 699034010301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034010302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010303 active site 699034010304 phosphorylation site [posttranslational modification] 699034010305 intermolecular recognition site; other site 699034010306 dimerization interface [polypeptide binding]; other site 699034010307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034010308 DNA binding site [nucleotide binding] 699034010309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034010310 oligoendopeptidase F; Region: pepF; TIGR00181 699034010311 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 699034010312 active site 699034010313 Zn binding site [ion binding]; other site 699034010314 MgtC family; Region: MgtC; pfam02308 699034010315 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 699034010316 FeoA domain; Region: FeoA; cl00838 699034010317 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 699034010318 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 699034010319 G1 box; other site 699034010320 GTP/Mg2+ binding site [chemical binding]; other site 699034010321 Switch I region; other site 699034010322 G2 box; other site 699034010323 G3 box; other site 699034010324 Switch II region; other site 699034010325 G4 box; other site 699034010326 G5 box; other site 699034010327 Nucleoside recognition; Region: Gate; cl00486 699034010328 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 699034010329 Nucleoside recognition; Region: Gate; cl00486 699034010330 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 699034010331 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 699034010332 dimer interface [polypeptide binding]; other site 699034010333 active site 699034010334 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 699034010335 dimer interface [polypeptide binding]; other site 699034010336 active site 699034010337 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 699034010338 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 699034010339 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 699034010340 active pocket/dimerization site; other site 699034010341 active site 699034010342 phosphorylation site [posttranslational modification] 699034010343 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 699034010344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034010345 Walker A motif; other site 699034010346 ATP binding site [chemical binding]; other site 699034010347 Walker B motif; other site 699034010348 arginine finger; other site 699034010349 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 699034010350 active pocket/dimerization site; other site 699034010351 active site 699034010352 phosphorylation site [posttranslational modification] 699034010353 PRD domain; Region: PRD; cl15445 699034010354 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 699034010355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010356 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 699034010357 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 699034010358 dimer interface [polypeptide binding]; other site 699034010359 active site 699034010360 glycine loop; other site 699034010361 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 699034010362 4Fe-4S binding domain; Region: Fer4; cl02805 699034010363 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 699034010364 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 699034010365 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 699034010366 protein binding site [polypeptide binding]; other site 699034010367 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 699034010368 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 699034010369 active site 699034010370 dimer interface [polypeptide binding]; other site 699034010371 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 699034010372 dimer interface [polypeptide binding]; other site 699034010373 active site 699034010374 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 699034010375 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 699034010376 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 699034010377 PhoU domain; Region: PhoU; pfam01895 699034010378 PhoU domain; Region: PhoU; pfam01895 699034010379 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 699034010380 SEC-C motif; Region: SEC-C; pfam02810 699034010381 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 699034010382 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 699034010383 potential frameshift: common BLAST hit: gi|260688497|ref|YP_003219631.1| type IV pilus-assembly protein 699034010384 type II secretion system protein E; Region: type_II_gspE; TIGR02533 699034010385 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 699034010386 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 699034010387 Walker A motif; other site 699034010388 ATP binding site [chemical binding]; other site 699034010389 Walker B motif; other site 699034010390 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 699034010391 hypothetical protein; Provisional; Region: PRK06851 699034010392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010393 Walker A motif; other site 699034010394 ATP binding site [chemical binding]; other site 699034010395 Walker B motif; other site 699034010396 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 699034010397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034010398 putative substrate translocation pore; other site 699034010399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034010400 Predicted GTPase [General function prediction only]; Region: COG0218 699034010401 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 699034010402 G1 box; other site 699034010403 GTP/Mg2+ binding site [chemical binding]; other site 699034010404 Switch I region; other site 699034010405 G2 box; other site 699034010406 G3 box; other site 699034010407 Switch II region; other site 699034010408 G4 box; other site 699034010409 G5 box; other site 699034010410 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 699034010411 Found in ATP-dependent protease La (LON); Region: LON; smart00464 699034010412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034010413 Walker A motif; other site 699034010414 ATP binding site [chemical binding]; other site 699034010415 Walker B motif; other site 699034010416 arginine finger; other site 699034010417 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 699034010418 Chromate transporter; Region: Chromate_transp; pfam02417 699034010419 Chromate transporter; Region: Chromate_transp; pfam02417 699034010420 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 699034010421 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 699034010422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034010423 Walker A motif; other site 699034010424 ATP binding site [chemical binding]; other site 699034010425 Walker B motif; other site 699034010426 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 699034010427 Clp protease; Region: CLP_protease; pfam00574 699034010428 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 699034010429 oligomer interface [polypeptide binding]; other site 699034010430 active site residues [active] 699034010431 trigger factor; Provisional; Region: tig; PRK01490 699034010432 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 699034010433 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 699034010434 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 699034010435 active site 699034010436 metal binding site [ion binding]; metal-binding site 699034010437 homotetramer interface [polypeptide binding]; other site 699034010438 ribonuclease PH; Reviewed; Region: rph; PRK00173 699034010439 Ribonuclease PH; Region: RNase_PH_bact; cd11362 699034010440 hexamer interface [polypeptide binding]; other site 699034010441 active site 699034010442 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 699034010443 active site 699034010444 dimerization interface [polypeptide binding]; other site 699034010445 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 699034010446 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 699034010447 nucleotide binding pocket [chemical binding]; other site 699034010448 K-X-D-G motif; other site 699034010449 catalytic site [active] 699034010450 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 699034010451 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 699034010452 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 699034010453 Dimer interface [polypeptide binding]; other site 699034010454 BRCT sequence motif; other site 699034010455 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 699034010456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010457 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 699034010458 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 699034010459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034010460 putative substrate translocation pore; other site 699034010461 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 699034010462 4Fe-4S binding domain; Region: Fer4; cl02805 699034010463 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 699034010464 4Fe-4S binding domain; Region: Fer4; cl02805 699034010465 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 699034010466 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 699034010467 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 699034010468 4Fe-4S binding domain; Region: Fer4; cl02805 699034010469 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 699034010470 potential frameshift: common BLAST hit: gi|260688520|ref|YP_003219654.1| formate dehydrogenase h 699034010471 Predicted integral membrane protein [Function unknown]; Region: COG0392 699034010472 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 699034010473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034010474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010475 active site 699034010476 phosphorylation site [posttranslational modification] 699034010477 intermolecular recognition site; other site 699034010478 dimerization interface [polypeptide binding]; other site 699034010479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034010480 DNA binding site [nucleotide binding] 699034010481 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 699034010482 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 699034010483 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 699034010484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034010485 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 699034010486 Walker A/P-loop; other site 699034010487 ATP binding site [chemical binding]; other site 699034010488 Q-loop/lid; other site 699034010489 ABC transporter signature motif; other site 699034010490 Walker B; other site 699034010491 D-loop; other site 699034010492 H-loop/switch region; other site 699034010493 Accessory gene regulator B; Region: AgrB; cl01873 699034010494 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 699034010495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 699034010496 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 699034010497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010498 active site 699034010499 phosphorylation site [posttranslational modification] 699034010500 intermolecular recognition site; other site 699034010501 dimerization interface [polypeptide binding]; other site 699034010502 LytTr DNA-binding domain; Region: LytTR; cl04498 699034010503 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 699034010504 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 699034010505 BclB C-terminal domain; Region: exospore_TM; TIGR03721 699034010506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 699034010507 active site 699034010508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034010509 binding surface 699034010510 TPR motif; other site 699034010511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034010512 binding surface 699034010513 TPR motif; other site 699034010514 Clp protease; Region: CLP_protease; pfam00574 699034010515 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 699034010516 oligomer interface [polypeptide binding]; other site 699034010517 active site residues [active] 699034010518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 699034010519 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 699034010520 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 699034010521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034010522 DNA-binding site [nucleotide binding]; DNA binding site 699034010523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034010524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034010525 homodimer interface [polypeptide binding]; other site 699034010526 catalytic residue [active] 699034010527 B3/4 domain; Region: B3_4; cl11458 699034010528 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 699034010529 putative FMN binding site [chemical binding]; other site 699034010530 Helix-turn-helix domains; Region: HTH; cl00088 699034010531 DJ-1 family protein; Region: not_thiJ; TIGR01383 699034010532 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 699034010533 conserved cys residue [active] 699034010534 AsnC family; Region: AsnC_trans_reg; pfam01037 699034010535 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 699034010536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010537 Walker A/P-loop; other site 699034010538 ATP binding site [chemical binding]; other site 699034010539 Q-loop/lid; other site 699034010540 ABC transporter signature motif; other site 699034010541 Walker B; other site 699034010542 D-loop; other site 699034010543 H-loop/switch region; other site 699034010544 ABC transporter; Region: ABC_tran_2; pfam12848 699034010545 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 699034010546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034010547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034010548 active site 699034010549 phosphorylation site [posttranslational modification] 699034010550 intermolecular recognition site; other site 699034010551 dimerization interface [polypeptide binding]; other site 699034010552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034010553 DNA binding site [nucleotide binding] 699034010554 putative efflux protein, MATE family; Region: matE; TIGR00797 699034010555 MatE; Region: MatE; cl10513 699034010556 MatE; Region: MatE; cl10513 699034010557 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 699034010558 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 699034010559 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 699034010560 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010561 Walker A/P-loop; other site 699034010562 ATP binding site [chemical binding]; other site 699034010563 Q-loop/lid; other site 699034010564 ABC transporter signature motif; other site 699034010565 Walker B; other site 699034010566 D-loop; other site 699034010567 H-loop/switch region; other site 699034010568 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 699034010569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 699034010570 metal binding site [ion binding]; metal-binding site 699034010571 active site 699034010572 I-site; other site 699034010573 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 699034010574 GTPase RsgA; Reviewed; Region: PRK01889 699034010575 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 699034010576 RNA binding site [nucleotide binding]; other site 699034010577 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 699034010578 GTPase/Zn-binding domain interface [polypeptide binding]; other site 699034010579 GTP/Mg2+ binding site [chemical binding]; other site 699034010580 G4 box; other site 699034010581 G5 box; other site 699034010582 G1 box; other site 699034010583 Switch I region; other site 699034010584 G2 box; other site 699034010585 G3 box; other site 699034010586 Switch II region; other site 699034010587 RNHCP domain; Region: RNHCP; pfam12647 699034010588 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 699034010589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034010590 pyruvate kinase; Provisional; Region: PRK06354 699034010591 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 699034010592 domain interfaces; other site 699034010593 active site 699034010594 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 699034010595 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 699034010596 active site 699034010597 ADP/pyrophosphate binding site [chemical binding]; other site 699034010598 dimerization interface [polypeptide binding]; other site 699034010599 allosteric effector site; other site 699034010600 fructose-1,6-bisphosphate binding site; other site 699034010601 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 699034010602 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 699034010603 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 699034010604 generic binding surface II; other site 699034010605 generic binding surface I; other site 699034010606 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 699034010607 active site 699034010608 Ap6A binding site [chemical binding]; other site 699034010609 nudix motif; other site 699034010610 metal binding site [ion binding]; metal-binding site 699034010611 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 699034010612 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 699034010613 phosphate binding site [ion binding]; other site 699034010614 putative substrate binding pocket [chemical binding]; other site 699034010615 dimer interface [polypeptide binding]; other site 699034010616 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 699034010617 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 699034010618 putative hydrolase; Validated; Region: PRK09248 699034010619 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 699034010620 FAD binding domain; Region: FAD_binding_4; pfam01565 699034010621 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 699034010622 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 699034010623 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 699034010624 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 699034010625 putative active site [active] 699034010626 catalytic site [active] 699034010627 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 699034010628 putative active site [active] 699034010629 catalytic site [active] 699034010630 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 699034010631 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 699034010632 putative dimer interface [polypeptide binding]; other site 699034010633 [2Fe-2S] cluster binding site [ion binding]; other site 699034010634 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 699034010635 dimer interface [polypeptide binding]; other site 699034010636 [2Fe-2S] cluster binding site [ion binding]; other site 699034010637 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 699034010638 SLBB domain; Region: SLBB; pfam10531 699034010639 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 699034010640 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 699034010641 4Fe-4S binding domain; Region: Fer4; cl02805 699034010642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 699034010643 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 699034010644 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 699034010645 4Fe-4S binding domain; Region: Fer4; cl02805 699034010646 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 699034010647 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 699034010648 MutS-like homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess...; Region: ABC_MutS-like; cd03283 699034010649 Walker A/P-loop; other site 699034010650 ATP binding site [chemical binding]; other site 699034010651 Q-loop/lid; other site 699034010652 ABC transporter signature motif; other site 699034010653 Walker B; other site 699034010654 D-loop; other site 699034010655 H-loop/switch region; other site 699034010656 DRTGG domain; Region: DRTGG; cl12147 699034010657 HPr kinase/phosphorylase; Provisional; Region: PRK05428 699034010658 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 699034010659 Hpr binding site; other site 699034010660 active site 699034010661 homohexamer subunit interaction site [polypeptide binding]; other site 699034010662 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 699034010663 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 699034010664 GIY-YIG motif/motif A; other site 699034010665 active site 699034010666 catalytic site [active] 699034010667 putative DNA binding site [nucleotide binding]; other site 699034010668 metal binding site [ion binding]; metal-binding site 699034010669 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 699034010670 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 699034010671 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034010672 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 699034010673 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 699034010674 excinuclease ABC subunit B; Provisional; Region: PRK05298 699034010675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034010676 ATP binding site [chemical binding]; other site 699034010677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034010678 nucleotide binding region [chemical binding]; other site 699034010679 ATP-binding site [chemical binding]; other site 699034010680 Ultra-violet resistance protein B; Region: UvrB; pfam12344 699034010681 UvrB/uvrC motif; Region: UVR; pfam02151 699034010682 Sulfatase; Region: Sulfatase; cl10460 699034010683 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 699034010684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034010685 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 699034010686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034010687 dimer interface [polypeptide binding]; other site 699034010688 conserved gate region; other site 699034010689 putative PBP binding loops; other site 699034010690 ABC-ATPase subunit interface; other site 699034010691 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 699034010692 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 699034010693 Walker A/P-loop; other site 699034010694 ATP binding site [chemical binding]; other site 699034010695 Q-loop/lid; other site 699034010696 ABC transporter signature motif; other site 699034010697 Walker B; other site 699034010698 D-loop; other site 699034010699 H-loop/switch region; other site 699034010700 potential RNA of insufficient length (23S ribosomal RNA) 699034010701 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 699034010702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010703 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 699034010704 dimer interface [polypeptide binding]; other site 699034010705 active site 699034010706 Schiff base residues; other site 699034010707 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034010708 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 699034010709 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 699034010710 active site 699034010711 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 699034010712 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 699034010713 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 699034010714 domain interfaces; other site 699034010715 active site 699034010716 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 699034010717 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 699034010718 active site 699034010719 C-terminal domain interface [polypeptide binding]; other site 699034010720 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 699034010721 active site 699034010722 N-terminal domain interface [polypeptide binding]; other site 699034010723 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034010724 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 699034010725 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 699034010726 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 699034010727 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034010728 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 699034010729 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 699034010730 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 699034010731 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 699034010732 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 699034010733 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034010734 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 699034010735 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 699034010736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034010737 S-adenosylmethionine binding site [chemical binding]; other site 699034010738 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034010739 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 699034010740 CbiD; Region: CbiD; cl00828 699034010741 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 699034010742 Precorrin-8X methylmutase; Region: CbiC; pfam02570 699034010743 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 699034010744 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 699034010745 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 699034010746 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 699034010747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034010748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034010749 homodimer interface [polypeptide binding]; other site 699034010750 catalytic residue [active] 699034010751 CobD/Cbib protein; Region: CobD_Cbib; cl00561 699034010752 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 699034010753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010754 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 699034010755 catalytic triad [active] 699034010756 cobyric acid synthase; Provisional; Region: PRK00784 699034010757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010758 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034010759 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 699034010760 catalytic triad [active] 699034010761 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 699034010762 catalytic core [active] 699034010763 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 699034010764 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 699034010765 homotrimer interface [polypeptide binding]; other site 699034010766 Walker A motif; other site 699034010767 GTP binding site [chemical binding]; other site 699034010768 Walker B motif; other site 699034010769 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 699034010770 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 699034010771 putative dimer interface [polypeptide binding]; other site 699034010772 active site pocket [active] 699034010773 putative cataytic base [active] 699034010774 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 699034010775 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 699034010776 active site 699034010777 catalytic residues [active] 699034010778 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 699034010779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034010780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034010781 homodimer interface [polypeptide binding]; other site 699034010782 catalytic residue [active] 699034010783 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 699034010784 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034010785 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 699034010786 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034010787 active site 699034010788 P-loop; other site 699034010789 phosphorylation site [posttranslational modification] 699034010790 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 699034010791 methionine cluster; other site 699034010792 active site 699034010793 phosphorylation site [posttranslational modification] 699034010794 metal binding site [ion binding]; metal-binding site 699034010795 exoaminopeptidase; Provisional; Region: PRK09961 699034010796 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 699034010797 oligomer interface [polypeptide binding]; other site 699034010798 active site 699034010799 metal binding site [ion binding]; metal-binding site 699034010800 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034010801 Helix-turn-helix domains; Region: HTH; cl00088 699034010802 PRD domain; Region: PRD; cl15445 699034010803 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034010804 active site 699034010805 P-loop; other site 699034010806 phosphorylation site [posttranslational modification] 699034010807 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034010808 active site 699034010809 phosphorylation site [posttranslational modification] 699034010810 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 699034010811 hypothetical protein; Provisional; Region: PRK08185 699034010812 intersubunit interface [polypeptide binding]; other site 699034010813 active site 699034010814 zinc binding site [ion binding]; other site 699034010815 Na+ binding site [ion binding]; other site 699034010816 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 699034010817 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 699034010818 dimer interface [polypeptide binding]; other site 699034010819 active site 699034010820 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 699034010821 putative active site [active] 699034010822 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 699034010823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034010824 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 699034010825 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 699034010826 putative substrate binding site [chemical binding]; other site 699034010827 putative ATP binding site [chemical binding]; other site 699034010828 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 699034010829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034010830 DNA-binding site [nucleotide binding]; DNA binding site 699034010831 UTRA domain; Region: UTRA; cl01230 699034010832 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 699034010833 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 699034010834 active site 699034010835 dimer interface [polypeptide binding]; other site 699034010836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 699034010837 Transposase, Mutator family; Region: Transposase_mut; pfam00872 699034010838 MULE transposase domain; Region: MULE; pfam10551 699034010839 NlpC/P60 family; Region: NLPC_P60; cl11438 699034010840 Fic family protein [Function unknown]; Region: COG3177 699034010841 Fic/DOC family; Region: Fic; cl00960 699034010842 multiple promoter invertase; Provisional; Region: mpi; PRK13413 699034010843 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 699034010844 catalytic residues [active] 699034010845 catalytic nucleophile [active] 699034010846 Presynaptic Site I dimer interface [polypeptide binding]; other site 699034010847 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 699034010848 Synaptic Flat tetramer interface [polypeptide binding]; other site 699034010849 Synaptic Site I dimer interface [polypeptide binding]; other site 699034010850 DNA binding site [nucleotide binding] 699034010851 potential frameshift: common BLAST hit: gi|302389842|ref|YP_003825663.1| phage protein 699034010852 potential frameshift: common BLAST hit: gi|302389842|ref|YP_003825663.1| phage protein 699034010853 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 699034010854 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 699034010855 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 699034010856 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 699034010857 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 699034010858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 699034010859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 699034010860 DNA binding residues [nucleotide binding] 699034010861 Transposase, Mutator family; Region: Transposase_mut; pfam00872 699034010862 MULE transposase domain; Region: MULE; pfam10551 699034010863 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 699034010864 Uncharacterized membrane protein [Function unknown]; Region: COG3949 699034010865 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 699034010866 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 699034010867 PYR/PP interface [polypeptide binding]; other site 699034010868 dimer interface [polypeptide binding]; other site 699034010869 TPP binding site [chemical binding]; other site 699034010870 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 699034010871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 699034010872 TPP-binding site [chemical binding]; other site 699034010873 dimer interface [polypeptide binding]; other site 699034010874 PemK-like protein; Region: PemK; cl00995 699034010875 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 699034010876 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 699034010877 alanine racemase; Reviewed; Region: alr; PRK00053 699034010878 active site 699034010879 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 699034010880 dimer interface [polypeptide binding]; other site 699034010881 substrate binding site [chemical binding]; other site 699034010882 catalytic residues [active] 699034010883 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 699034010884 FOG: CBS domain [General function prediction only]; Region: COG0517 699034010885 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 699034010886 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 699034010887 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 699034010888 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 699034010889 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 699034010890 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 699034010891 alpha subunit interaction interface [polypeptide binding]; other site 699034010892 Walker A motif; other site 699034010893 ATP binding site [chemical binding]; other site 699034010894 Walker B motif; other site 699034010895 inhibitor binding site; inhibition site 699034010896 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 699034010897 ATP synthase; Region: ATP-synt; cl00365 699034010898 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 699034010899 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 699034010900 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 699034010901 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 699034010902 beta subunit interaction interface [polypeptide binding]; other site 699034010903 Walker A motif; other site 699034010904 ATP binding site [chemical binding]; other site 699034010905 Walker B motif; other site 699034010906 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 699034010907 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 699034010908 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 699034010909 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 699034010910 ATP synthase subunit C; Region: ATP-synt_C; cl00466 699034010911 ATP synthase A chain; Region: ATP-synt_A; cl00413 699034010912 ATP synthase I chain; Region: ATP_synt_I; cl09170 699034010913 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 699034010914 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 699034010915 catalytic motif [active] 699034010916 Zn binding site [ion binding]; other site 699034010917 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 699034010918 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 699034010919 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034010920 active site 699034010921 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 699034010922 Low molecular weight phosphatase family; Region: LMWPc; cd00115 699034010923 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 699034010924 active site 699034010925 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 699034010926 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 699034010927 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 699034010928 peptide chain release factor 1; Validated; Region: prfA; PRK00591 699034010929 RF-1 domain; Region: RF-1; cl02875 699034010930 RF-1 domain; Region: RF-1; cl02875 699034010931 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 699034010932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034010933 S-adenosylmethionine binding site [chemical binding]; other site 699034010934 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 699034010935 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 699034010936 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 699034010937 transcription termination factor Rho; Provisional; Region: PRK12608 699034010938 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 699034010939 RNA binding site [nucleotide binding]; other site 699034010940 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 699034010941 multimer interface [polypeptide binding]; other site 699034010942 Walker A motif; other site 699034010943 ATP binding site [chemical binding]; other site 699034010944 Walker B motif; other site 699034010945 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 699034010946 active site 699034010947 tetramer interface; other site 699034010948 oligoendopeptidase F; Region: pepF; TIGR00181 699034010949 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 699034010950 active site 699034010951 Zn binding site [ion binding]; other site 699034010952 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 699034010953 Septum formation initiator; Region: DivIC; cl11433 699034010954 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 699034010955 YabP family; Region: YabP; cl06766 699034010956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 699034010957 RNA binding surface [nucleotide binding]; other site 699034010958 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 699034010959 IHF - DNA interface [nucleotide binding]; other site 699034010960 IHF dimer interface [polypeptide binding]; other site 699034010961 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034010962 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 699034010963 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 699034010964 homodimer interface [polypeptide binding]; other site 699034010965 metal binding site [ion binding]; metal-binding site 699034010966 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 699034010967 homodimer interface [polypeptide binding]; other site 699034010968 active site 699034010969 putative chemical substrate binding site [chemical binding]; other site 699034010970 metal binding site [ion binding]; metal-binding site 699034010971 stage V sporulation protein B; Region: spore_V_B; TIGR02900 699034010972 MatE; Region: MatE; cl10513 699034010973 MatE; Region: MatE; cl10513 699034010974 stage V sporulation protein T; Region: spore_V_T; TIGR02851 699034010975 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 699034010976 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 699034010977 SurA N-terminal domain; Region: SurA_N_3; cl07813 699034010978 PPIC-type PPIASE domain; Region: Rotamase; cl08278 699034010979 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 699034010980 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 699034010981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 699034010982 ATP binding site [chemical binding]; other site 699034010983 putative Mg++ binding site [ion binding]; other site 699034010984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 699034010985 nucleotide binding region [chemical binding]; other site 699034010986 ATP-binding site [chemical binding]; other site 699034010987 TRCF domain; Region: TRCF; cl04088 699034010988 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 699034010989 putative active site [active] 699034010990 catalytic residue [active] 699034010991 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 699034010992 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 699034010993 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 699034010994 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 699034010995 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 699034010996 Walker A motif; other site 699034010997 ATP binding site [chemical binding]; other site 699034010998 Walker B motif; other site 699034010999 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 699034011000 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 699034011001 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 699034011002 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 699034011003 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 699034011004 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 699034011005 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 699034011006 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 699034011007 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 699034011008 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 699034011009 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 699034011010 Walker A motif; other site 699034011011 ATP binding site [chemical binding]; other site 699034011012 Walker B motif; other site 699034011013 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 699034011014 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 699034011015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034011016 active site 699034011017 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 699034011018 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 699034011019 Substrate binding site; other site 699034011020 Mg++ binding site; other site 699034011021 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 699034011022 active site 699034011023 substrate binding site [chemical binding]; other site 699034011024 CoA binding site [chemical binding]; other site 699034011025 SpoVG; Region: SpoVG; cl00915 699034011026 pur operon repressor; Provisional; Region: PRK09213 699034011027 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 699034011028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 699034011029 active site 699034011030 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 699034011031 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 699034011032 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 699034011033 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 699034011034 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 699034011035 Cation efflux family; Region: Cation_efflux; cl00316 699034011036 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 699034011037 peptidase T-like protein; Region: PepT-like; TIGR01883 699034011038 metal binding site [ion binding]; metal-binding site 699034011039 putative dimer interface [polypeptide binding]; other site 699034011040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034011041 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 699034011042 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 699034011043 putative active site [active] 699034011044 putative metal binding site [ion binding]; other site 699034011045 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 699034011046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034011047 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 699034011048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 699034011049 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 699034011050 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 699034011051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034011052 dimer interface [polypeptide binding]; other site 699034011053 conserved gate region; other site 699034011054 putative PBP binding loops; other site 699034011055 ABC-ATPase subunit interface; other site 699034011056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 699034011057 dimer interface [polypeptide binding]; other site 699034011058 conserved gate region; other site 699034011059 putative PBP binding loops; other site 699034011060 ABC-ATPase subunit interface; other site 699034011061 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 699034011062 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034011063 Walker A/P-loop; other site 699034011064 ATP binding site [chemical binding]; other site 699034011065 Q-loop/lid; other site 699034011066 ABC transporter signature motif; other site 699034011067 Walker B; other site 699034011068 D-loop; other site 699034011069 H-loop/switch region; other site 699034011070 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 699034011071 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 699034011072 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034011073 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034011074 active site 699034011075 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 699034011076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034011077 Walker A/P-loop; other site 699034011078 ATP binding site [chemical binding]; other site 699034011079 Q-loop/lid; other site 699034011080 ABC transporter signature motif; other site 699034011081 Walker B; other site 699034011082 D-loop; other site 699034011083 H-loop/switch region; other site 699034011084 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 699034011085 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 699034011086 Walker A/P-loop; other site 699034011087 ATP binding site [chemical binding]; other site 699034011088 Q-loop/lid; other site 699034011089 ABC transporter signature motif; other site 699034011090 Walker B; other site 699034011091 D-loop; other site 699034011092 H-loop/switch region; other site 699034011093 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 699034011094 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 699034011095 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; cl01455 699034011096 Phosphonate metabolism protein PhnG; Region: PhnG; cl01454 699034011097 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 699034011098 active site 699034011099 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 699034011100 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 699034011101 active site 699034011102 HIGH motif; other site 699034011103 KMSKS motif; other site 699034011104 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 699034011105 tRNA binding surface [nucleotide binding]; other site 699034011106 anticodon binding site; other site 699034011107 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 699034011108 dimer interface [polypeptide binding]; other site 699034011109 putative tRNA-binding site [nucleotide binding]; other site 699034011110 Nucleoside recognition; Region: Gate; cl00486 699034011111 Nucleoside recognition; Region: Gate; cl00486 699034011112 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 699034011113 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 699034011114 active site 699034011115 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 699034011116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 699034011117 putative DNA binding site [nucleotide binding]; other site 699034011118 putative Zn2+ binding site [ion binding]; other site 699034011119 AsnC family; Region: AsnC_trans_reg; pfam01037 699034011120 PII uridylyl-transferase; Provisional; Region: PRK05092 699034011121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 699034011122 Predicted methyltransferases [General function prediction only]; Region: COG0313 699034011123 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 699034011124 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 699034011125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034011126 PSP1 C-terminal conserved region; Region: PSP1; cl00770 699034011127 DNA polymerase III subunit delta'; Validated; Region: PRK05564 699034011128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034011129 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 699034011130 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 699034011131 TMP-binding site; other site 699034011132 ATP-binding site [chemical binding]; other site 699034011133 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 699034011134 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034011135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034011136 catalytic residue [active] 699034011137 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 699034011138 Domain of unknown function (DUF378); Region: DUF378; cl00943 699034011139 potential RNA of insufficient length (23S ribosomal RNA) 699034011140 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 699034011141 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 699034011142 dimer interface [polypeptide binding]; other site 699034011143 putative anticodon binding site; other site 699034011144 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 699034011145 motif 1; other site 699034011146 active site 699034011147 motif 2; other site 699034011148 motif 3; other site 699034011149 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 699034011150 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 699034011151 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 699034011152 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 699034011153 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 699034011154 FMN binding site [chemical binding]; other site 699034011155 active site 699034011156 catalytic residues [active] 699034011157 substrate binding site [chemical binding]; other site 699034011158 Type III pantothenate kinase; Region: Pan_kinase; cl09130 699034011159 Predicted membrane protein [Function unknown]; Region: COG4684 699034011160 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 699034011161 putative active site pocket [active] 699034011162 cleavage site 699034011163 Helix-turn-helix domains; Region: HTH; cl00088 699034011164 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 699034011165 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 699034011166 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 699034011167 Ligand Binding Site [chemical binding]; other site 699034011168 B3/4 domain; Region: B3_4; cl11458 699034011169 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 699034011170 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 699034011171 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 699034011172 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 699034011173 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 699034011174 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 699034011175 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 699034011176 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 699034011177 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 699034011178 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 699034011179 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 699034011180 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 699034011181 YabG peptidase U57; Region: Peptidase_U57; cl05250 699034011182 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 699034011183 active site 699034011184 dimer interface [polypeptide binding]; other site 699034011185 hypothetical protein; Provisional; Region: PRK05590 699034011186 UPF0489 domain; Region: UPF0489; pfam12640 699034011187 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 699034011188 Na binding site [ion binding]; other site 699034011189 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 699034011190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 699034011191 putative substrate translocation pore; other site 699034011192 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 699034011193 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 699034011194 homodimer interface [polypeptide binding]; other site 699034011195 substrate-cofactor binding pocket; other site 699034011196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034011197 catalytic residue [active] 699034011198 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 699034011199 catalytic residues [active] 699034011200 catalytic nucleophile [active] 699034011201 Presynaptic Site I dimer interface [polypeptide binding]; other site 699034011202 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 699034011203 Synaptic Flat tetramer interface [polypeptide binding]; other site 699034011204 Synaptic Site I dimer interface [polypeptide binding]; other site 699034011205 DNA binding site [nucleotide binding] 699034011206 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 699034011207 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 699034011208 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 699034011209 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 699034011210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 699034011211 S-adenosylmethionine binding site [chemical binding]; other site 699034011212 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 699034011213 active site 699034011214 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 699034011215 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034011216 DNA binding residues [nucleotide binding] 699034011217 drug binding residues [chemical binding]; other site 699034011218 dimer interface [polypeptide binding]; other site 699034011219 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034011220 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 699034011221 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 699034011222 FtsX-like permease family; Region: FtsX; cl15850 699034011223 FtsX-like permease family; Region: FtsX; cl15850 699034011224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 699034011225 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034011226 Walker A/P-loop; other site 699034011227 ATP binding site [chemical binding]; other site 699034011228 Q-loop/lid; other site 699034011229 ABC transporter signature motif; other site 699034011230 Walker B; other site 699034011231 D-loop; other site 699034011232 H-loop/switch region; other site 699034011233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 699034011234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034011235 ATP binding site [chemical binding]; other site 699034011236 Mg2+ binding site [ion binding]; other site 699034011237 G-X-G motif; other site 699034011238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034011239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034011240 active site 699034011241 phosphorylation site [posttranslational modification] 699034011242 intermolecular recognition site; other site 699034011243 dimerization interface [polypeptide binding]; other site 699034011244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034011245 DNA binding site [nucleotide binding] 699034011246 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 699034011247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 699034011248 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034011249 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 699034011250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 699034011251 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034011252 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 699034011253 IMP binding site; other site 699034011254 dimer interface [polypeptide binding]; other site 699034011255 interdomain contacts; other site 699034011256 partial ornithine binding site; other site 699034011257 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 699034011258 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 699034011259 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 699034011260 catalytic site [active] 699034011261 subunit interface [polypeptide binding]; other site 699034011262 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 699034011263 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 699034011264 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034011265 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 699034011266 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 699034011267 ATP-grasp domain; Region: ATP-grasp_4; cl03087 699034011268 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 699034011269 IMP binding site; other site 699034011270 dimer interface [polypeptide binding]; other site 699034011271 interdomain contacts; other site 699034011272 partial ornithine binding site; other site 699034011273 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 699034011274 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 699034011275 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 699034011276 catalytic site [active] 699034011277 subunit interface [polypeptide binding]; other site 699034011278 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 699034011279 active site 699034011280 dimer interface [polypeptide binding]; other site 699034011281 Protein of unknown function (DUF1847); Region: DUF1847; cl02037 699034011282 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034011283 FMN binding site [chemical binding]; other site 699034011284 dimer interface [polypeptide binding]; other site 699034011285 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 699034011286 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 699034011287 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 699034011288 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 699034011289 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 699034011290 substrate binding pocket [chemical binding]; other site 699034011291 dimer interface [polypeptide binding]; other site 699034011292 inhibitor binding site; inhibition site 699034011293 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 699034011294 B12 binding site [chemical binding]; other site 699034011295 cobalt ligand [ion binding]; other site 699034011296 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 699034011297 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 699034011298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 699034011299 dimer interface [polypeptide binding]; other site 699034011300 phosphorylation site [posttranslational modification] 699034011301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 699034011302 ATP binding site [chemical binding]; other site 699034011303 Mg2+ binding site [ion binding]; other site 699034011304 G-X-G motif; other site 699034011305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 699034011306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 699034011307 active site 699034011308 phosphorylation site [posttranslational modification] 699034011309 intermolecular recognition site; other site 699034011310 dimerization interface [polypeptide binding]; other site 699034011311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 699034011312 DNA binding site [nucleotide binding] 699034011313 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 699034011314 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 699034011315 Ligand Binding Site [chemical binding]; other site 699034011316 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 699034011317 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 699034011318 putative active site [active] 699034011319 putative metal binding site [ion binding]; other site 699034011320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 699034011321 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 699034011322 putative NAD(P) binding site [chemical binding]; other site 699034011323 active site 699034011324 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 699034011325 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 699034011326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 699034011327 motif II; other site 699034011328 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 699034011329 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 699034011330 dihydroorotase; Provisional; Region: PRK09237 699034011331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034011332 active site 699034011333 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 699034011334 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 699034011335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034011336 Walker A/P-loop; other site 699034011337 ATP binding site [chemical binding]; other site 699034011338 Q-loop/lid; other site 699034011339 ABC transporter signature motif; other site 699034011340 Walker B; other site 699034011341 D-loop; other site 699034011342 H-loop/switch region; other site 699034011343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 699034011344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 699034011345 MATE family multidrug exporter; Provisional; Region: PRK10189 699034011346 MatE; Region: MatE; cl10513 699034011347 MatE; Region: MatE; cl10513 699034011348 Staygreen protein; Region: Staygreen; pfam12638 699034011349 Protein of unknown function, DUF488; Region: DUF488; cl01246 699034011350 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 699034011351 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 699034011352 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 699034011353 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 699034011354 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 699034011355 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 699034011356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 699034011357 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 699034011358 YcxB-like protein; Region: YcxB; pfam14317 699034011359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 699034011360 Replication initiation factor; Region: Rep_trans; pfam02486 699034011361 Protein of unknown function (DUF3789); Region: DUF3789; pfam12664 699034011362 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 699034011363 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 699034011364 Antirestriction protein (ArdA); Region: ArdA; cl01953 699034011365 Antirestriction protein (ArdA); Region: ArdA; cl01953 699034011366 TcpE family; Region: TcpE; pfam12648 699034011367 AAA-like domain; Region: AAA_10; pfam12846 699034011368 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 699034011369 YtxH-like protein; Region: YtxH; cl02079 699034011370 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 699034011371 NlpC/P60 family; Region: NLPC_P60; cl11438 699034011372 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 699034011373 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 699034011374 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 699034011375 Helix-turn-helix domains; Region: HTH; cl00088 699034011376 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 699034011377 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 699034011378 Walker A/P-loop; other site 699034011379 ATP binding site [chemical binding]; other site 699034011380 Q-loop/lid; other site 699034011381 ABC transporter signature motif; other site 699034011382 Walker B; other site 699034011383 D-loop; other site 699034011384 H-loop/switch region; other site 699034011385 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 699034011386 Cation efflux family; Region: Cation_efflux; cl00316 699034011387 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 699034011388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 699034011389 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 699034011390 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 699034011391 Int/Topo IB signature motif; other site 699034011392 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 699034011393 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 699034011394 DNA binding residues [nucleotide binding] 699034011395 drug binding residues [chemical binding]; other site 699034011396 dimer interface [polypeptide binding]; other site 699034011397 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 699034011398 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 699034011399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 699034011400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 699034011401 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 699034011402 Probable transposase; Region: OrfB_IS605; pfam01385 699034011403 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 699034011404 Transposase IS200 like; Region: Y1_Tnp; cl00848 699034011405 potassium/proton antiporter; Reviewed; Region: PRK05326 699034011406 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 699034011407 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 699034011408 dimer interface [polypeptide binding]; other site 699034011409 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 699034011410 YmaF family; Region: YmaF; pfam12788 699034011411 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 699034011412 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 699034011413 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 699034011414 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 699034011415 PhnA protein; Region: PhnA; pfam03831 699034011416 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 699034011417 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 699034011418 Walker A/P-loop; other site 699034011419 ATP binding site [chemical binding]; other site 699034011420 Q-loop/lid; other site 699034011421 ABC transporter signature motif; other site 699034011422 Walker B; other site 699034011423 D-loop; other site 699034011424 H-loop/switch region; other site 699034011425 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 699034011426 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 699034011427 KDPG and KHG aldolase; Region: Aldolase; pfam01081 699034011428 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 699034011429 active site 699034011430 intersubunit interface [polypeptide binding]; other site 699034011431 catalytic residue [active] 699034011432 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 699034011433 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 699034011434 inhibitor site; inhibition site 699034011435 active site 699034011436 dimer interface [polypeptide binding]; other site 699034011437 catalytic residue [active] 699034011438 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 699034011439 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 699034011440 putative active site [active] 699034011441 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 699034011442 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 699034011443 active site 699034011444 P-loop; other site 699034011445 phosphorylation site [posttranslational modification] 699034011446 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 699034011447 PRD domain; Region: PRD; cl15445 699034011448 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 699034011449 active site 699034011450 P-loop; other site 699034011451 phosphorylation site [posttranslational modification] 699034011452 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 699034011453 active site 699034011454 phosphorylation site [posttranslational modification] 699034011455 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 699034011456 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 699034011457 Uncharacterized conserved protein [Function unknown]; Region: COG5276 699034011458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 699034011459 Helix-turn-helix domains; Region: HTH; cl00088 699034011460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 699034011461 dimerization interface [polypeptide binding]; other site 699034011462 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 699034011463 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 699034011464 substrate binding site [chemical binding]; other site 699034011465 ATP binding site [chemical binding]; other site 699034011466 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 699034011467 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 699034011468 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 699034011469 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 699034011470 active site 699034011471 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 699034011472 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034011473 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 699034011474 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 699034011475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 699034011476 DNA-binding site [nucleotide binding]; DNA binding site 699034011477 UTRA domain; Region: UTRA; cl01230 699034011478 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 699034011479 active site 699034011480 methionine cluster; other site 699034011481 phosphorylation site [posttranslational modification] 699034011482 metal binding site [ion binding]; metal-binding site 699034011483 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 699034011484 active site 699034011485 P-loop; other site 699034011486 phosphorylation site [posttranslational modification] 699034011487 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 699034011488 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 699034011489 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 699034011490 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 699034011491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 699034011492 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 699034011493 Zn binding site [ion binding]; other site 699034011494 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 699034011495 DNA replication protein DnaC; Validated; Region: PRK06835 699034011496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 699034011497 Walker A motif; other site 699034011498 ATP binding site [chemical binding]; other site 699034011499 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 699034011500 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 699034011501 GDP-binding site [chemical binding]; other site 699034011502 ACT binding site; other site 699034011503 IMP binding site; other site 699034011504 replicative DNA helicase; Region: DnaB; TIGR00665 699034011505 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 699034011506 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 699034011507 Walker A motif; other site 699034011508 ATP binding site [chemical binding]; other site 699034011509 Walker B motif; other site 699034011510 DNA binding loops [nucleotide binding] 699034011511 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 699034011512 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 699034011513 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 699034011514 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 699034011515 DHH family; Region: DHH; pfam01368 699034011516 DHHA1 domain; Region: DHHA1; pfam02272 699034011517 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 699034011518 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 699034011519 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 699034011520 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 699034011521 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 699034011522 dimer interface [polypeptide binding]; other site 699034011523 ssDNA binding site [nucleotide binding]; other site 699034011524 tetramer (dimer of dimers) interface [polypeptide binding]; other site 699034011525 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 699034011526 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 699034011527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 699034011528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 699034011529 homodimer interface [polypeptide binding]; other site 699034011530 catalytic residue [active] 699034011531 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 699034011532 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 699034011533 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 699034011534 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 699034011535 CPxP motif; other site 699034011536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 699034011537 non-specific DNA binding site [nucleotide binding]; other site 699034011538 salt bridge; other site 699034011539 sequence-specific DNA binding site [nucleotide binding]; other site 699034011540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 699034011541 binding surface 699034011542 TPR motif; other site 699034011543 Tetratricopeptide repeat; Region: TPR_12; pfam13424 699034011544 Tetratricopeptide repeat; Region: TPR_12; pfam13424 699034011545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 699034011546 Sporulation and spore germination; Region: Germane; cl11253 699034011547 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 699034011548 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 699034011549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 699034011550 catalytic residue [active] 699034011551 ParB-like partition proteins; Region: parB_part; TIGR00180 699034011552 ParB-like nuclease domain; Region: ParBc; cl02129 699034011553 KorB domain; Region: KorB; pfam08535 699034011554 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 699034011555 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 699034011556 P-loop; other site 699034011557 Magnesium ion binding site [ion binding]; other site 699034011558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 699034011559 Magnesium ion binding site [ion binding]; other site 699034011560 ParB-like partition proteins; Region: parB_part; TIGR00180 699034011561 ParB-like nuclease domain; Region: ParBc; cl02129 699034011562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 699034011563 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 699034011564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 699034011565 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 699034011566 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 699034011567 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 699034011568 trmE is a tRNA modification GTPase; Region: trmE; cd04164 699034011569 G1 box; other site 699034011570 GTP/Mg2+ binding site [chemical binding]; other site 699034011571 Switch I region; other site 699034011572 G2 box; other site 699034011573 Switch II region; other site 699034011574 G3 box; other site 699034011575 G4 box; other site 699034011576 G5 box; other site 699034011577 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 699034011578 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 699034011579 G-X-X-G motif; other site 699034011580 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 699034011581 RxxxH motif; other site 699034011582 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 699034011583 Haemolytic domain; Region: Haemolytic; cl00506 699034011584 Ribonuclease P; Region: Ribonuclease_P; cl00457 699034011585 Ribosomal protein L34; Region: Ribosomal_L34; cl00370