-- dump date 20120504_142651 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1144275000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1144275000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1144275000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275000004 Walker A motif; other site 1144275000005 ATP binding site [chemical binding]; other site 1144275000006 Walker B motif; other site 1144275000007 arginine finger; other site 1144275000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1144275000009 DnaA box-binding interface [nucleotide binding]; other site 1144275000010 FOG: CBS domain [General function prediction only]; Region: COG0517 1144275000011 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1144275000012 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1144275000013 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275000014 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275000015 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275000016 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275000017 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275000018 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275000019 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1144275000020 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1144275000021 nucleotide binding site [chemical binding]; other site 1144275000022 substrate binding site [chemical binding]; other site 1144275000023 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1144275000024 dimer interface [polypeptide binding]; other site 1144275000025 putative threonine allosteric regulatory site; other site 1144275000026 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1144275000027 putative threonine allosteric regulatory site; other site 1144275000028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275000029 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1144275000030 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275000031 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1144275000032 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1144275000033 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275000034 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1144275000035 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1144275000036 putative active site [active] 1144275000037 putative metal binding site [ion binding]; other site 1144275000038 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275000039 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1144275000040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275000041 Helix-turn-helix domain; Region: HTH_18; pfam12833 1144275000042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275000043 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275000044 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275000045 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275000046 hydrophobic ligand binding site; other site 1144275000047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275000048 dimerization interface [polypeptide binding]; other site 1144275000049 putative DNA binding site [nucleotide binding]; other site 1144275000050 putative Zn2+ binding site [ion binding]; other site 1144275000051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275000052 H+ Antiporter protein; Region: 2A0121; TIGR00900 1144275000053 putative substrate translocation pore; other site 1144275000054 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275000055 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1144275000056 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1144275000057 putative active site [active] 1144275000058 putative metal binding site [ion binding]; other site 1144275000059 DoxX; Region: DoxX; cl00976 1144275000060 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1144275000061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275000062 glutathione synthetase; Provisional; Region: PRK05246 1144275000063 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1144275000064 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275000065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275000066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275000067 active site 1144275000068 ATP binding site [chemical binding]; other site 1144275000069 substrate binding site [chemical binding]; other site 1144275000070 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275000071 substrate binding site [chemical binding]; other site 1144275000072 activation loop (A-loop); other site 1144275000073 activation loop (A-loop); other site 1144275000074 Protein of unknown function (DUF429); Region: DUF429; cl12046 1144275000075 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275000076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275000077 active site 1144275000078 catalytic tetrad [active] 1144275000079 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1144275000080 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275000081 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275000082 active site 1144275000083 ATP binding site [chemical binding]; other site 1144275000084 substrate binding site [chemical binding]; other site 1144275000085 activation loop (A-loop); other site 1144275000086 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1144275000087 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275000088 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1144275000089 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1144275000090 ribonuclease R; Region: RNase_R; TIGR02063 1144275000091 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275000092 RNB domain; Region: RNB; pfam00773 1144275000093 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1144275000094 RNA binding site [nucleotide binding]; other site 1144275000095 Flagellin N-methylase; Region: FliB; cl00497 1144275000096 LabA_like proteins; Region: LabA_like/DUF88; cl10034 1144275000097 putative metal binding site [ion binding]; other site 1144275000098 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1144275000099 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1144275000100 NMT1-like family; Region: NMT1_2; cl15260 1144275000101 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1144275000102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275000103 dimer interface [polypeptide binding]; other site 1144275000104 conserved gate region; other site 1144275000105 putative PBP binding loops; other site 1144275000106 ABC-ATPase subunit interface; other site 1144275000107 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1144275000108 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1144275000109 Walker A/P-loop; other site 1144275000110 ATP binding site [chemical binding]; other site 1144275000111 Q-loop/lid; other site 1144275000112 ABC transporter signature motif; other site 1144275000113 Walker B; other site 1144275000114 D-loop; other site 1144275000115 H-loop/switch region; other site 1144275000116 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275000117 Glucose dehydrogenase; Region: glucose_DH; cd08230 1144275000118 NADP binding site [chemical binding]; other site 1144275000119 catalytic Zn binding site [ion binding]; other site 1144275000120 structural Zn binding site [ion binding]; other site 1144275000121 dimer interface [polypeptide binding]; other site 1144275000122 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1144275000123 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1144275000124 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1144275000125 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1144275000126 polyphosphate kinase; Provisional; Region: PRK05443 1144275000127 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1144275000128 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1144275000129 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1144275000130 putative domain interface [polypeptide binding]; other site 1144275000131 putative active site [active] 1144275000132 catalytic site [active] 1144275000133 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1144275000134 putative domain interface [polypeptide binding]; other site 1144275000135 putative active site [active] 1144275000136 catalytic site [active] 1144275000137 trigger factor; Region: tig; TIGR00115 1144275000138 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1144275000139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000140 PAS domain; Region: PAS_9; pfam13426 1144275000141 putative active site [active] 1144275000142 heme pocket [chemical binding]; other site 1144275000143 GAF domain; Region: GAF; cl15785 1144275000144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000146 ATP binding site [chemical binding]; other site 1144275000147 Mg2+ binding site [ion binding]; other site 1144275000148 G-X-G motif; other site 1144275000149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275000150 Cupin domain; Region: Cupin_2; cl09118 1144275000151 Divergent AAA domain; Region: AAA_4; pfam04326 1144275000152 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1144275000153 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275000154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275000155 active site 1144275000156 metal binding site [ion binding]; metal-binding site 1144275000157 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275000158 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275000159 PilZ domain; Region: PilZ; cl01260 1144275000160 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1144275000161 hypothetical protein; Reviewed; Region: PRK09588 1144275000162 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 1144275000163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000164 binding surface 1144275000165 TPR motif; other site 1144275000166 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1144275000167 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275000168 CoenzymeA binding site [chemical binding]; other site 1144275000169 subunit interaction site [polypeptide binding]; other site 1144275000170 PHB binding site; other site 1144275000171 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275000172 CoenzymeA binding site [chemical binding]; other site 1144275000173 subunit interaction site [polypeptide binding]; other site 1144275000174 PHB binding site; other site 1144275000175 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275000176 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275000177 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275000178 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275000179 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275000180 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275000181 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1144275000182 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275000183 Amidohydrolase; Region: Amidohydro_4; pfam13147 1144275000184 active site 1144275000185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000186 PAS fold; Region: PAS_3; pfam08447 1144275000187 putative active site [active] 1144275000188 heme pocket [chemical binding]; other site 1144275000189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000190 putative active site [active] 1144275000191 heme pocket [chemical binding]; other site 1144275000192 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275000193 GAF domain; Region: GAF; cl15785 1144275000194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000195 PAS fold; Region: PAS_3; pfam08447 1144275000196 putative active site [active] 1144275000197 heme pocket [chemical binding]; other site 1144275000198 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1144275000199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000200 ATP binding site [chemical binding]; other site 1144275000201 Mg2+ binding site [ion binding]; other site 1144275000202 G-X-G motif; other site 1144275000203 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275000204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000205 active site 1144275000206 phosphorylation site [posttranslational modification] 1144275000207 intermolecular recognition site; other site 1144275000208 dimerization interface [polypeptide binding]; other site 1144275000209 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000211 active site 1144275000212 phosphorylation site [posttranslational modification] 1144275000213 intermolecular recognition site; other site 1144275000214 dimerization interface [polypeptide binding]; other site 1144275000215 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275000216 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1144275000217 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275000218 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 1144275000219 metal binding site [ion binding]; metal-binding site 1144275000220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275000221 putative substrate translocation pore; other site 1144275000222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275000223 FG-GAP repeat; Region: FG-GAP; cl15299 1144275000224 Family description; Region: VCBS; pfam13517 1144275000225 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 1144275000226 FG-GAP repeat; Region: FG-GAP; cl15299 1144275000227 Family description; Region: VCBS; pfam13517 1144275000228 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 1144275000229 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275000230 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1144275000231 FtsX-like permease family; Region: FtsX; cl15850 1144275000232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275000233 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1144275000234 FtsX-like permease family; Region: FtsX; cl15850 1144275000235 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1144275000236 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1144275000237 putative active site [active] 1144275000238 catalytic site [active] 1144275000239 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1144275000240 putative active site [active] 1144275000241 catalytic site [active] 1144275000242 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1144275000243 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1144275000244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275000245 Coenzyme A binding pocket [chemical binding]; other site 1144275000246 Predicted kinase [General function prediction only]; Region: COG4639 1144275000247 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1144275000248 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1144275000249 active site 1144275000250 metal binding site [ion binding]; metal-binding site 1144275000251 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1144275000252 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1144275000253 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275000254 tetrameric interface [polypeptide binding]; other site 1144275000255 NAD binding site [chemical binding]; other site 1144275000256 catalytic residues [active] 1144275000257 hypothetical protein; Validated; Region: PRK07198 1144275000258 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1144275000259 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1144275000260 dimerization interface [polypeptide binding]; other site 1144275000261 active site 1144275000262 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1144275000263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275000264 active site 1144275000265 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1144275000266 cleavage site 1144275000267 active site 1144275000268 substrate binding sites [chemical binding]; other site 1144275000269 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1144275000270 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275000271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275000272 S-adenosylmethionine binding site [chemical binding]; other site 1144275000273 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1144275000274 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1144275000275 putative active site [active] 1144275000276 putative metal binding site [ion binding]; other site 1144275000277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275000278 active site 1144275000279 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1144275000280 Cl- selectivity filter; other site 1144275000281 Cl- binding residues [ion binding]; other site 1144275000282 pore gating glutamate residue; other site 1144275000283 dimer interface [polypeptide binding]; other site 1144275000284 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1144275000285 active site 1144275000286 oxyanion hole [active] 1144275000287 SlyX; Region: SlyX; cl01090 1144275000288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000289 TPR motif; other site 1144275000290 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275000291 binding surface 1144275000292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000293 binding surface 1144275000294 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275000295 TPR motif; other site 1144275000296 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1144275000297 LPS O-antigen length regulator; Provisional; Region: PRK10381 1144275000298 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275000299 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1144275000300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275000301 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1144275000302 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1144275000303 active site 1144275000304 catalytic residues [active] 1144275000305 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1144275000306 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275000307 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1144275000308 catalytic residues [active] 1144275000309 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1144275000310 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000312 active site 1144275000313 phosphorylation site [posttranslational modification] 1144275000314 intermolecular recognition site; other site 1144275000315 dimerization interface [polypeptide binding]; other site 1144275000316 PAS fold; Region: PAS_4; pfam08448 1144275000317 putative diguanylate cyclase; Provisional; Region: PRK09776 1144275000318 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275000319 GAF domain; Region: GAF_2; pfam13185 1144275000320 GAF domain; Region: GAF; cl15785 1144275000321 PAS fold; Region: PAS_4; pfam08448 1144275000322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000323 PAS fold; Region: PAS_3; pfam08447 1144275000324 putative active site [active] 1144275000325 heme pocket [chemical binding]; other site 1144275000326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275000327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000328 dimer interface [polypeptide binding]; other site 1144275000329 phosphorylation site [posttranslational modification] 1144275000330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000331 ATP binding site [chemical binding]; other site 1144275000332 Mg2+ binding site [ion binding]; other site 1144275000333 G-X-G motif; other site 1144275000334 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000336 active site 1144275000337 phosphorylation site [posttranslational modification] 1144275000338 intermolecular recognition site; other site 1144275000339 dimerization interface [polypeptide binding]; other site 1144275000340 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275000341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000342 active site 1144275000343 phosphorylation site [posttranslational modification] 1144275000344 intermolecular recognition site; other site 1144275000345 dimerization interface [polypeptide binding]; other site 1144275000346 putative diguanylate cyclase; Provisional; Region: PRK09776 1144275000347 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275000348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000349 dimer interface [polypeptide binding]; other site 1144275000350 phosphorylation site [posttranslational modification] 1144275000351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000352 ATP binding site [chemical binding]; other site 1144275000353 Mg2+ binding site [ion binding]; other site 1144275000354 G-X-G motif; other site 1144275000355 Haemolytic domain; Region: Haemolytic; cl00506 1144275000356 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1144275000357 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1144275000358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275000359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275000360 dimer interface [polypeptide binding]; other site 1144275000361 conserved gate region; other site 1144275000362 putative PBP binding loops; other site 1144275000363 ABC-ATPase subunit interface; other site 1144275000364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1144275000365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275000366 dimer interface [polypeptide binding]; other site 1144275000367 conserved gate region; other site 1144275000368 putative PBP binding loops; other site 1144275000369 ABC-ATPase subunit interface; other site 1144275000370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275000371 NAD(P) binding site [chemical binding]; other site 1144275000372 active site 1144275000373 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1144275000374 PLD-like domain; Region: PLDc_2; pfam13091 1144275000375 putative active site [active] 1144275000376 catalytic site [active] 1144275000377 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1144275000378 putative active site [active] 1144275000379 catalytic site [active] 1144275000380 YCII-related domain; Region: YCII; cl00999 1144275000381 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1144275000382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275000383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275000384 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275000385 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1144275000386 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275000387 glutathione reductase; Validated; Region: PRK06116 1144275000388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275000389 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1144275000390 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275000391 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275000392 active site 1144275000393 ATP binding site [chemical binding]; other site 1144275000394 substrate binding site [chemical binding]; other site 1144275000395 activation loop (A-loop); other site 1144275000396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275000397 Predicted ATPase [General function prediction only]; Region: COG3899 1144275000398 Trm112p-like protein; Region: Trm112p; cl01066 1144275000399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275000400 S-adenosylmethionine binding site [chemical binding]; other site 1144275000401 classical (c) SDRs; Region: SDR_c; cd05233 1144275000402 NAD(P) binding site [chemical binding]; other site 1144275000403 active site 1144275000404 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1144275000405 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275000406 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275000407 Domain of unknown function (DUF955); Region: DUF955; cl01076 1144275000408 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1144275000409 putative acyl-acceptor binding pocket; other site 1144275000410 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1144275000411 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275000412 active site 1144275000413 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275000414 ligand binding site [chemical binding]; other site 1144275000415 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1144275000416 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1144275000417 active site 1144275000418 nucleophile elbow; other site 1144275000419 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1144275000420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275000421 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275000422 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275000423 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275000424 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1144275000425 HEAT repeats; Region: HEAT_2; pfam13646 1144275000426 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275000427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000428 TPR motif; other site 1144275000429 binding surface 1144275000430 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275000431 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1144275000432 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275000433 Domain of unknown function (DUF427); Region: DUF427; cl00998 1144275000434 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1144275000435 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1144275000436 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1144275000437 Walker A/P-loop; other site 1144275000438 ATP binding site [chemical binding]; other site 1144275000439 Q-loop/lid; other site 1144275000440 ABC transporter signature motif; other site 1144275000441 Walker B; other site 1144275000442 D-loop; other site 1144275000443 H-loop/switch region; other site 1144275000444 TOBE domain; Region: TOBE_2; cl01440 1144275000445 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275000446 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275000447 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275000448 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275000449 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275000450 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1144275000451 active site 1144275000452 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1144275000453 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1144275000454 active site 1144275000455 catalytic residues [active] 1144275000456 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1144275000457 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275000458 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1144275000459 catalytic residues [active] 1144275000460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275000461 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275000462 active site 1144275000463 ATP binding site [chemical binding]; other site 1144275000464 substrate binding site [chemical binding]; other site 1144275000465 activation loop (A-loop); other site 1144275000466 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 1144275000467 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1144275000468 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1144275000469 FMN-binding pocket [chemical binding]; other site 1144275000470 flavin binding motif; other site 1144275000471 phosphate binding motif [ion binding]; other site 1144275000472 beta-alpha-beta structure motif; other site 1144275000473 NAD binding pocket [chemical binding]; other site 1144275000474 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1144275000475 catalytic loop [active] 1144275000476 iron binding site [ion binding]; other site 1144275000477 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1144275000478 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1144275000479 Isochorismatase family; Region: Isochorismatase; pfam00857 1144275000480 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1144275000481 catalytic triad [active] 1144275000482 conserved cis-peptide bond; other site 1144275000483 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1144275000484 Cu(I) binding site [ion binding]; other site 1144275000485 FixH; Region: FixH; cl01254 1144275000486 EAP30/Vps36 family; Region: EAP30; pfam04157 1144275000487 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1144275000488 putative active site [active] 1144275000489 metal binding site [ion binding]; metal-binding site 1144275000490 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1144275000491 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1144275000492 potential catalytic triad [active] 1144275000493 conserved cys residue [active] 1144275000494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275000495 Helix-turn-helix domains; Region: HTH; cl00088 1144275000496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275000497 dimerization interface [polypeptide binding]; other site 1144275000498 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275000499 putative catalytic site [active] 1144275000500 putative metal binding site [ion binding]; other site 1144275000501 putative phosphate binding site [ion binding]; other site 1144275000502 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1144275000503 Lamin Tail Domain; Region: LTD; pfam00932 1144275000504 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1144275000505 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275000506 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275000507 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1144275000508 putative NAD(P) binding site [chemical binding]; other site 1144275000509 active site 1144275000510 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1144275000511 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1144275000512 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275000513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275000514 DNA-binding site [nucleotide binding]; DNA binding site 1144275000515 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1144275000516 nudix motif; other site 1144275000517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1144275000518 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1144275000519 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1144275000520 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1144275000521 catalytic triad [active] 1144275000522 conserved cis-peptide bond; other site 1144275000523 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275000524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000525 binding surface 1144275000526 TPR motif; other site 1144275000527 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1144275000528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275000529 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275000530 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1144275000531 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1144275000532 AP (apurinic/apyrimidinic) site pocket; other site 1144275000533 DNA interaction; other site 1144275000534 Metal-binding active site; metal-binding site 1144275000535 YcaO-like family; Region: YcaO; pfam02624 1144275000536 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 1144275000537 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275000538 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1144275000539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275000540 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1144275000541 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1144275000542 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1144275000543 MatE; Region: MatE; cl10513 1144275000544 MatE; Region: MatE; cl10513 1144275000545 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1144275000546 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1144275000547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275000548 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275000549 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1144275000550 universal stress protein UspE; Provisional; Region: PRK11175 1144275000551 Cupin domain; Region: Cupin_2; cl09118 1144275000552 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1144275000553 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1144275000554 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1144275000555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275000556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000557 dimer interface [polypeptide binding]; other site 1144275000558 phosphorylation site [posttranslational modification] 1144275000559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000560 ATP binding site [chemical binding]; other site 1144275000561 Mg2+ binding site [ion binding]; other site 1144275000562 G-X-G motif; other site 1144275000563 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000565 active site 1144275000566 phosphorylation site [posttranslational modification] 1144275000567 intermolecular recognition site; other site 1144275000568 dimerization interface [polypeptide binding]; other site 1144275000569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275000570 non-specific DNA binding site [nucleotide binding]; other site 1144275000571 salt bridge; other site 1144275000572 sequence-specific DNA binding site [nucleotide binding]; other site 1144275000573 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1144275000574 active site 1144275000575 oxyanion hole [active] 1144275000576 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1144275000577 active site 1144275000578 oxyanion hole [active] 1144275000579 catalytic triad [active] 1144275000580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275000581 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275000582 Double zinc ribbon; Region: DZR; pfam12773 1144275000583 Yip1 domain; Region: Yip1; cl12048 1144275000584 Verru_Chthon cassette protein A; Region: Verru_Chthon_A; TIGR02600 1144275000585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275000586 TPR repeat; Region: TPR_11; pfam13414 1144275000587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000588 binding surface 1144275000589 TPR motif; other site 1144275000590 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1144275000591 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1144275000592 active site 1144275000593 metal binding site [ion binding]; metal-binding site 1144275000594 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1144275000595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1144275000596 alanine racemase; Reviewed; Region: alr; PRK00053 1144275000597 active site 1144275000598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275000599 dimer interface [polypeptide binding]; other site 1144275000600 substrate binding site [chemical binding]; other site 1144275000601 catalytic residues [active] 1144275000602 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1144275000603 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1144275000604 putative acyl-acceptor binding pocket; other site 1144275000605 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1144275000606 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1144275000607 Zn binding site [ion binding]; other site 1144275000608 enoyl-CoA hydratase; Provisional; Region: PRK06688 1144275000609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275000610 substrate binding site [chemical binding]; other site 1144275000611 oxyanion hole (OAH) forming residues; other site 1144275000612 trimer interface [polypeptide binding]; other site 1144275000613 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1144275000614 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1144275000615 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275000616 active site 1144275000617 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275000618 active site 1144275000619 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 1144275000620 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1144275000621 catalytic site [active] 1144275000622 putative active site [active] 1144275000623 putative substrate binding site [chemical binding]; other site 1144275000624 dimer interface [polypeptide binding]; other site 1144275000625 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000627 active site 1144275000628 phosphorylation site [posttranslational modification] 1144275000629 intermolecular recognition site; other site 1144275000630 dimerization interface [polypeptide binding]; other site 1144275000631 malonyl-CoA synthase; Validated; Region: PRK07514 1144275000632 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275000633 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275000634 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275000635 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275000636 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275000637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275000638 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275000639 Walker A/P-loop; other site 1144275000640 ATP binding site [chemical binding]; other site 1144275000641 Q-loop/lid; other site 1144275000642 ABC transporter signature motif; other site 1144275000643 Walker B; other site 1144275000644 D-loop; other site 1144275000645 H-loop/switch region; other site 1144275000646 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1144275000647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275000648 FtsX-like permease family; Region: FtsX; cl15850 1144275000649 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275000650 FtsX-like permease family; Region: FtsX; cl15850 1144275000651 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275000652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000653 active site 1144275000654 phosphorylation site [posttranslational modification] 1144275000655 intermolecular recognition site; other site 1144275000656 dimerization interface [polypeptide binding]; other site 1144275000657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275000658 Walker A motif; other site 1144275000659 ATP binding site [chemical binding]; other site 1144275000660 Walker B motif; other site 1144275000661 arginine finger; other site 1144275000662 Helix-turn-helix domains; Region: HTH; cl00088 1144275000663 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1144275000664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275000665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000666 ATP binding site [chemical binding]; other site 1144275000667 Mg2+ binding site [ion binding]; other site 1144275000668 G-X-G motif; other site 1144275000669 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275000670 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275000671 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1144275000672 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275000673 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275000674 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275000675 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1144275000676 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275000677 GRAS family transcription factor; Region: GRAS; pfam03514 1144275000678 Competence-damaged protein; Region: CinA; cl00666 1144275000679 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275000680 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275000681 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275000682 putative di-iron ligands [ion binding]; other site 1144275000683 Family description; Region: VCBS; pfam13517 1144275000684 Family description; Region: VCBS; pfam13517 1144275000685 Family description; Region: VCBS; pfam13517 1144275000686 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1144275000687 GH3 auxin-responsive promoter; Region: GH3; cl04006 1144275000688 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1144275000689 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1144275000690 [2Fe-2S] cluster binding site [ion binding]; other site 1144275000691 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275000692 hydrophobic ligand binding site; other site 1144275000693 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1144275000694 putative trimer interface [polypeptide binding]; other site 1144275000695 putative CoA binding site [chemical binding]; other site 1144275000696 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1144275000697 putative trimer interface [polypeptide binding]; other site 1144275000698 putative CoA binding site [chemical binding]; other site 1144275000699 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1144275000700 MatE; Region: MatE; cl10513 1144275000701 MatE; Region: MatE; cl10513 1144275000702 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1144275000703 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1144275000704 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1144275000705 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275000706 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1144275000707 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275000708 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 1144275000709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000710 binding surface 1144275000711 TPR motif; other site 1144275000712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000713 TPR motif; other site 1144275000714 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275000715 binding surface 1144275000716 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 1144275000717 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1144275000718 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1144275000719 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1144275000720 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1144275000721 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275000722 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 1144275000723 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 1144275000724 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1144275000725 active site 1144275000726 Zn binding site [ion binding]; other site 1144275000727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275000728 putative transporter; Provisional; Region: PRK10504 1144275000729 putative substrate translocation pore; other site 1144275000730 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1144275000731 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1144275000732 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275000733 active site 1144275000734 substrate binding sites [chemical binding]; other site 1144275000735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275000736 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275000737 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275000738 catalytic residue [active] 1144275000739 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1144275000740 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275000741 HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244 1144275000742 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275000743 hydrophobic ligand binding site; other site 1144275000744 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1144275000745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275000746 Helix-turn-helix domains; Region: HTH; cl00088 1144275000747 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275000748 putative effector binding pocket; other site 1144275000749 putative dimerization interface [polypeptide binding]; other site 1144275000750 short chain dehydrogenase; Provisional; Region: PRK06180 1144275000751 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1144275000752 NADP binding site [chemical binding]; other site 1144275000753 active site 1144275000754 steroid binding site; other site 1144275000755 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275000756 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275000757 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275000758 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275000759 active site 1144275000760 ATP binding site [chemical binding]; other site 1144275000761 substrate binding site [chemical binding]; other site 1144275000762 activation loop (A-loop); other site 1144275000763 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1144275000764 methionine aminopeptidase; Provisional; Region: PRK12318 1144275000765 SEC-C motif; Region: SEC-C; pfam02810 1144275000766 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1144275000767 active site 1144275000768 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1144275000769 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1144275000770 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1144275000771 Ca binding site [ion binding]; other site 1144275000772 active site 1144275000773 catalytic site [active] 1144275000774 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1144275000775 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1144275000776 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1144275000777 active site 1144275000778 catalytic site [active] 1144275000779 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1144275000780 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1144275000781 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1144275000782 Walker A/P-loop; other site 1144275000783 ATP binding site [chemical binding]; other site 1144275000784 Q-loop/lid; other site 1144275000785 ABC transporter signature motif; other site 1144275000786 Walker B; other site 1144275000787 D-loop; other site 1144275000788 H-loop/switch region; other site 1144275000789 TOBE domain; Region: TOBE_2; cl01440 1144275000790 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1144275000791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275000792 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1144275000793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1144275000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275000795 dimer interface [polypeptide binding]; other site 1144275000796 conserved gate region; other site 1144275000797 putative PBP binding loops; other site 1144275000798 ABC-ATPase subunit interface; other site 1144275000799 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1144275000800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275000801 dimer interface [polypeptide binding]; other site 1144275000802 conserved gate region; other site 1144275000803 putative PBP binding loops; other site 1144275000804 ABC-ATPase subunit interface; other site 1144275000805 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 1144275000806 putative ligand binding site [chemical binding]; other site 1144275000807 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1144275000808 putative ligand binding site [chemical binding]; other site 1144275000809 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275000810 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1144275000811 trehalose synthase; Region: treS_nterm; TIGR02456 1144275000812 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 1144275000813 Ca binding site [ion binding]; other site 1144275000814 active site 1144275000815 catalytic site [active] 1144275000816 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275000817 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1144275000818 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B [DNA replication, recombination, and repair]; Region: HYS2; COG1311 1144275000819 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275000820 active site 1144275000821 GAF domain; Region: GAF; cl15785 1144275000822 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000823 dimer interface [polypeptide binding]; other site 1144275000824 phosphorylation site [posttranslational modification] 1144275000825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000826 ATP binding site [chemical binding]; other site 1144275000827 Mg2+ binding site [ion binding]; other site 1144275000828 G-X-G motif; other site 1144275000829 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1144275000830 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1144275000831 putative substrate binding site [chemical binding]; other site 1144275000832 putative ATP binding site [chemical binding]; other site 1144275000833 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1144275000834 active site 1144275000835 phosphorylation site [posttranslational modification] 1144275000836 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1144275000837 dimerization domain swap beta strand [polypeptide binding]; other site 1144275000838 regulatory protein interface [polypeptide binding]; other site 1144275000839 active site 1144275000840 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1144275000841 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1144275000842 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1144275000843 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1144275000844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275000845 S-adenosylmethionine binding site [chemical binding]; other site 1144275000846 Protein of unknown function (DUF962); Region: DUF962; cl01879 1144275000847 Pirin-related protein [General function prediction only]; Region: COG1741 1144275000848 Cupin domain; Region: Cupin_2; cl09118 1144275000849 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1144275000850 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1144275000851 FMN binding site [chemical binding]; other site 1144275000852 active site 1144275000853 substrate binding site [chemical binding]; other site 1144275000854 catalytic residue [active] 1144275000855 Cupin domain; Region: Cupin_2; cl09118 1144275000856 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1144275000857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275000858 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275000859 Helix-turn-helix domains; Region: HTH; cl00088 1144275000860 DNA-binding site [nucleotide binding]; DNA binding site 1144275000861 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1144275000862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275000863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275000864 Walker A/P-loop; other site 1144275000865 Walker A/P-loop; other site 1144275000866 ATP binding site [chemical binding]; other site 1144275000867 ATP binding site [chemical binding]; other site 1144275000868 Q-loop/lid; other site 1144275000869 ABC transporter signature motif; other site 1144275000870 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1144275000871 putative active site [active] 1144275000872 putative metal-binding site [ion binding]; other site 1144275000873 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1144275000874 Catalytic site [active] 1144275000875 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1144275000876 hypothetical protein; Provisional; Region: PRK06156 1144275000877 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1144275000878 active site 1144275000879 metal binding site [ion binding]; metal-binding site 1144275000880 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1144275000881 GAF domain; Region: GAF_2; pfam13185 1144275000882 GAF domain; Region: GAF; cl15785 1144275000883 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275000884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000885 dimer interface [polypeptide binding]; other site 1144275000886 phosphorylation site [posttranslational modification] 1144275000887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000888 ATP binding site [chemical binding]; other site 1144275000889 Mg2+ binding site [ion binding]; other site 1144275000890 G-X-G motif; other site 1144275000891 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1144275000892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275000893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000894 TPR motif; other site 1144275000895 binding surface 1144275000896 TPR repeat; Region: TPR_11; pfam13414 1144275000897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000898 binding surface 1144275000899 TPR motif; other site 1144275000900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275000901 TPR motif; other site 1144275000902 binding surface 1144275000903 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1144275000904 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275000905 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1144275000906 NmrA-like family; Region: NmrA; pfam05368 1144275000907 NADP binding site [chemical binding]; other site 1144275000908 active site 1144275000909 regulatory binding site [polypeptide binding]; other site 1144275000910 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 1144275000911 PAS domain S-box; Region: sensory_box; TIGR00229 1144275000912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000913 putative active site [active] 1144275000914 heme pocket [chemical binding]; other site 1144275000915 PAS domain S-box; Region: sensory_box; TIGR00229 1144275000916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275000917 putative active site [active] 1144275000918 heme pocket [chemical binding]; other site 1144275000919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000920 dimer interface [polypeptide binding]; other site 1144275000921 phosphorylation site [posttranslational modification] 1144275000922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000923 ATP binding site [chemical binding]; other site 1144275000924 Mg2+ binding site [ion binding]; other site 1144275000925 G-X-G motif; other site 1144275000926 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000928 active site 1144275000929 phosphorylation site [posttranslational modification] 1144275000930 intermolecular recognition site; other site 1144275000931 dimerization interface [polypeptide binding]; other site 1144275000932 Cytochrome c [Energy production and conversion]; Region: COG3258 1144275000933 Cytochrome c; Region: Cytochrom_C; cl11414 1144275000934 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1144275000935 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1144275000936 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275000937 ligand binding site [chemical binding]; other site 1144275000938 flexible hinge region; other site 1144275000939 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275000940 ligand binding site [chemical binding]; other site 1144275000941 flexible hinge region; other site 1144275000942 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275000943 ligand binding site [chemical binding]; other site 1144275000944 flexible hinge region; other site 1144275000945 SEC-C motif; Region: SEC-C; pfam02810 1144275000946 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275000947 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 1144275000948 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 1144275000949 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 1144275000950 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1144275000951 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1144275000952 Ligand binding site; other site 1144275000953 metal-binding site 1144275000954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275000955 ligand binding site [chemical binding]; other site 1144275000956 hypothetical protein; Provisional; Region: PRK13560 1144275000957 GAF domain; Region: GAF_2; pfam13185 1144275000958 GAF domain; Region: GAF; cl15785 1144275000959 PAS fold; Region: PAS_4; pfam08448 1144275000960 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275000961 GAF domain; Region: GAF; cl15785 1144275000962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275000963 dimer interface [polypeptide binding]; other site 1144275000964 phosphorylation site [posttranslational modification] 1144275000965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000966 ATP binding site [chemical binding]; other site 1144275000967 Mg2+ binding site [ion binding]; other site 1144275000968 G-X-G motif; other site 1144275000969 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1144275000970 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1144275000971 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1144275000972 beta subunit interaction interface [polypeptide binding]; other site 1144275000973 Walker A motif; other site 1144275000974 ATP binding site [chemical binding]; other site 1144275000975 Walker B motif; other site 1144275000976 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1144275000977 PAS fold; Region: PAS_4; pfam08448 1144275000978 PAS domain S-box; Region: sensory_box; TIGR00229 1144275000979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275000980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275000981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275000982 ATP binding site [chemical binding]; other site 1144275000983 Mg2+ binding site [ion binding]; other site 1144275000984 G-X-G motif; other site 1144275000985 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1144275000986 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1144275000987 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275000988 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1144275000989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275000990 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275000991 active site 1144275000992 phosphorylation site [posttranslational modification] 1144275000993 intermolecular recognition site; other site 1144275000994 dimerization interface [polypeptide binding]; other site 1144275000995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275000996 active site 1144275000997 phosphorylation site [posttranslational modification] 1144275000998 intermolecular recognition site; other site 1144275000999 dimerization interface [polypeptide binding]; other site 1144275001000 PilZ domain; Region: PilZ; cl01260 1144275001001 Beta propeller domain; Region: Beta_propel; pfam09826 1144275001002 multidrug efflux protein; Reviewed; Region: PRK01766 1144275001003 MatE; Region: MatE; cl10513 1144275001004 MatE; Region: MatE; cl10513 1144275001005 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275001006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275001007 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1144275001008 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275001009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001010 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 1144275001011 putative hydrophobic ligand binding site [chemical binding]; other site 1144275001012 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001014 active site 1144275001015 phosphorylation site [posttranslational modification] 1144275001016 intermolecular recognition site; other site 1144275001017 dimerization interface [polypeptide binding]; other site 1144275001018 PAS domain S-box; Region: sensory_box; TIGR00229 1144275001019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275001020 putative active site [active] 1144275001021 heme pocket [chemical binding]; other site 1144275001022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1144275001023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001024 dimer interface [polypeptide binding]; other site 1144275001025 phosphorylation site [posttranslational modification] 1144275001026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001027 ATP binding site [chemical binding]; other site 1144275001028 Mg2+ binding site [ion binding]; other site 1144275001029 G-X-G motif; other site 1144275001030 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001032 active site 1144275001033 phosphorylation site [posttranslational modification] 1144275001034 intermolecular recognition site; other site 1144275001035 dimerization interface [polypeptide binding]; other site 1144275001036 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275001037 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1144275001038 LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455 1144275001039 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1144275001040 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1144275001041 putative C-terminal domain interface [polypeptide binding]; other site 1144275001042 putative GSH binding site (G-site) [chemical binding]; other site 1144275001043 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275001044 putative dimer interface [polypeptide binding]; other site 1144275001045 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1144275001046 dimer interface [polypeptide binding]; other site 1144275001047 N-terminal domain interface [polypeptide binding]; other site 1144275001048 putative substrate binding pocket (H-site) [chemical binding]; other site 1144275001049 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1144275001050 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1144275001051 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275001052 active site 1144275001053 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1144275001054 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1144275001055 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1144275001056 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275001057 metal ion-dependent adhesion site (MIDAS); other site 1144275001058 thymidylate kinase; Region: DTMP_kinase; TIGR00041 1144275001059 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1144275001060 recombination protein F; Reviewed; Region: recF; PRK00064 1144275001061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001062 AAA domain; Region: AAA_21; pfam13304 1144275001063 Walker A/P-loop; other site 1144275001064 ATP binding site [chemical binding]; other site 1144275001065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001066 Q-loop/lid; other site 1144275001067 ABC transporter signature motif; other site 1144275001068 Walker B; other site 1144275001069 D-loop; other site 1144275001070 H-loop/switch region; other site 1144275001071 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1144275001072 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1144275001073 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1144275001074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275001075 S-adenosylmethionine binding site [chemical binding]; other site 1144275001076 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1144275001077 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1144275001078 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1144275001079 active site 1144275001080 catalytic site [active] 1144275001081 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1144275001082 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1144275001083 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275001084 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1144275001085 active site 1144275001086 catalytic residues [active] 1144275001087 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1144275001088 GtrA-like protein; Region: GtrA; cl00971 1144275001089 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1144275001090 active site 1144275001091 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1144275001092 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1144275001093 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275001094 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1144275001095 active site 1144275001096 catalytic tetrad [active] 1144275001097 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1144275001098 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1144275001099 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1144275001100 putative NAD(P) binding site [chemical binding]; other site 1144275001101 putative substrate binding site [chemical binding]; other site 1144275001102 catalytic Zn binding site [ion binding]; other site 1144275001103 structural Zn binding site [ion binding]; other site 1144275001104 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1144275001105 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1144275001106 Active site serine [active] 1144275001107 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1144275001108 30S subunit binding site; other site 1144275001109 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275001110 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275001111 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275001112 active site 1144275001113 catalytic tetrad [active] 1144275001114 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1144275001115 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1144275001116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275001117 dimerization interface [polypeptide binding]; other site 1144275001118 putative DNA binding site [nucleotide binding]; other site 1144275001119 putative Zn2+ binding site [ion binding]; other site 1144275001120 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1144275001121 putative hydrophobic ligand binding site [chemical binding]; other site 1144275001122 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1144275001123 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1144275001124 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1144275001125 SurA N-terminal domain; Region: SurA_N_3; cl07813 1144275001126 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1144275001127 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1144275001128 SurA N-terminal domain; Region: SurA_N_3; cl07813 1144275001129 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1144275001130 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1144275001131 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1144275001132 GIY-YIG motif/motif A; other site 1144275001133 putative active site [active] 1144275001134 putative metal binding site [ion binding]; other site 1144275001135 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 1144275001136 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275001137 FeS/SAM binding site; other site 1144275001138 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1144275001139 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1144275001140 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1144275001141 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1144275001142 putative NADH binding site [chemical binding]; other site 1144275001143 putative active site [active] 1144275001144 nudix motif; other site 1144275001145 putative metal binding site [ion binding]; other site 1144275001146 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275001147 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1144275001148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275001149 putative substrate translocation pore; other site 1144275001150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275001151 Coenzyme A binding pocket [chemical binding]; other site 1144275001152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275001153 binding surface 1144275001154 TPR motif; other site 1144275001155 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275001156 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275001157 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1144275001158 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275001159 N-terminal plug; other site 1144275001160 ligand-binding site [chemical binding]; other site 1144275001161 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1144275001162 nucleotide binding site/active site [active] 1144275001163 HIT family signature motif; other site 1144275001164 catalytic residue [active] 1144275001165 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275001166 Bacterial Ig-like domain; Region: Big_5; cl01012 1144275001167 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001169 active site 1144275001170 phosphorylation site [posttranslational modification] 1144275001171 intermolecular recognition site; other site 1144275001172 dimerization interface [polypeptide binding]; other site 1144275001173 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275001174 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275001175 active site 1144275001176 ATP binding site [chemical binding]; other site 1144275001177 substrate binding site [chemical binding]; other site 1144275001178 activation loop (A-loop); other site 1144275001179 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275001180 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275001181 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275001182 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275001183 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1144275001184 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1144275001185 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 1144275001186 Cupin domain; Region: Cupin_2; cl09118 1144275001187 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275001188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275001189 aspartate aminotransferase; Provisional; Region: PRK05764 1144275001190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275001191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275001192 homodimer interface [polypeptide binding]; other site 1144275001193 catalytic residue [active] 1144275001194 ATP/ADP translocase [Energy production and conversion]; Region: COG3202; cl03940 1144275001195 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275001196 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1144275001197 putative NAD(P) binding site [chemical binding]; other site 1144275001198 active site 1144275001199 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1144275001200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275001201 DNA topoisomerase III; Provisional; Region: PRK07726 1144275001202 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1144275001203 active site 1144275001204 putative interdomain interaction site [polypeptide binding]; other site 1144275001205 putative metal-binding site [ion binding]; other site 1144275001206 putative nucleotide binding site [chemical binding]; other site 1144275001207 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1144275001208 domain I; other site 1144275001209 phosphate binding site [ion binding]; other site 1144275001210 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1144275001211 domain II; other site 1144275001212 domain III; other site 1144275001213 nucleotide binding site [chemical binding]; other site 1144275001214 DNA binding groove [nucleotide binding] 1144275001215 catalytic site [active] 1144275001216 domain IV; other site 1144275001217 ATP-dependent DNA helicase; Q4-like; Provisional; Region: PLN03137 1144275001218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275001219 ATP binding site [chemical binding]; other site 1144275001220 putative Mg++ binding site [ion binding]; other site 1144275001221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275001222 nucleotide binding region [chemical binding]; other site 1144275001223 ATP-binding site [chemical binding]; other site 1144275001224 HRDC domain; Region: HRDC; cl02578 1144275001225 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275001226 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1144275001227 active site 1144275001228 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1144275001229 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001230 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275001231 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1144275001232 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1144275001233 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1144275001234 catalytic site [active] 1144275001235 active site 1144275001236 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1144275001237 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275001238 hypothetical protein; Provisional; Region: PRK07907 1144275001239 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1144275001240 metal binding site [ion binding]; metal-binding site 1144275001241 putative dimer interface [polypeptide binding]; other site 1144275001242 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275001243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1144275001244 active site 1144275001245 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275001246 Protein kinase domain; Region: Pkinase; pfam00069 1144275001247 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275001248 active site 1144275001249 ATP binding site [chemical binding]; other site 1144275001250 substrate binding site [chemical binding]; other site 1144275001251 activation loop (A-loop); other site 1144275001252 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275001253 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275001254 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1144275001255 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275001256 Walker A/P-loop; other site 1144275001257 ATP binding site [chemical binding]; other site 1144275001258 Q-loop/lid; other site 1144275001259 ABC transporter signature motif; other site 1144275001260 Walker B; other site 1144275001261 D-loop; other site 1144275001262 H-loop/switch region; other site 1144275001263 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1144275001264 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275001265 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275001266 ABC transporter; Region: ABC_tran_2; pfam12848 1144275001267 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275001268 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1144275001269 active site 1144275001270 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275001271 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275001272 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275001273 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275001274 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1144275001275 Family description; Region: VCBS; pfam13517 1144275001276 Family description; Region: VCBS; pfam13517 1144275001277 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1144275001278 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1144275001279 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275001280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275001281 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275001282 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275001283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275001284 Putative esterase; Region: Esterase; pfam00756 1144275001285 Lamin Tail Domain; Region: LTD; pfam00932 1144275001286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275001287 PAS fold; Region: PAS_4; pfam08448 1144275001288 putative diguanylate cyclase; Provisional; Region: PRK09776 1144275001289 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275001290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001291 dimer interface [polypeptide binding]; other site 1144275001292 phosphorylation site [posttranslational modification] 1144275001293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001294 ATP binding site [chemical binding]; other site 1144275001295 Mg2+ binding site [ion binding]; other site 1144275001296 G-X-G motif; other site 1144275001297 Integral membrane protein TerC family; Region: TerC; cl10468 1144275001298 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1144275001299 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1144275001300 active site 1144275001301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1144275001302 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1144275001303 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 1144275001304 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275001305 MG2 domain; Region: A2M_N; pfam01835 1144275001306 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1144275001307 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1144275001308 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1144275001309 surface patch; other site 1144275001310 thioester region; other site 1144275001311 specificity defining residues; other site 1144275001312 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1144275001313 Stage II sporulation protein; Region: SpoIID; pfam08486 1144275001314 Domain of unknown function (DUF305); Region: DUF305; cl15795 1144275001315 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1144275001316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001317 Walker A/P-loop; other site 1144275001318 ATP binding site [chemical binding]; other site 1144275001319 Q-loop/lid; other site 1144275001320 ABC transporter signature motif; other site 1144275001321 Walker B; other site 1144275001322 D-loop; other site 1144275001323 H-loop/switch region; other site 1144275001324 NMT1-like family; Region: NMT1_2; cl15260 1144275001325 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1144275001326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275001327 dimer interface [polypeptide binding]; other site 1144275001328 conserved gate region; other site 1144275001329 ABC-ATPase subunit interface; other site 1144275001330 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1144275001331 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1144275001332 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275001333 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1144275001334 NAD(P) binding site [chemical binding]; other site 1144275001335 catalytic residues [active] 1144275001336 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275001337 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1144275001338 active site 1144275001339 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1144275001340 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1144275001341 putative trimer interface [polypeptide binding]; other site 1144275001342 putative CoA binding site [chemical binding]; other site 1144275001343 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1144275001344 trimer interface [polypeptide binding]; other site 1144275001345 active site 1144275001346 substrate binding site [chemical binding]; other site 1144275001347 CoA binding site [chemical binding]; other site 1144275001348 PAS fold; Region: PAS; pfam00989 1144275001349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275001350 putative active site [active] 1144275001351 heme pocket [chemical binding]; other site 1144275001352 GAF domain; Region: GAF; cl15785 1144275001353 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275001354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275001355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001356 dimer interface [polypeptide binding]; other site 1144275001357 phosphorylation site [posttranslational modification] 1144275001358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001359 ATP binding site [chemical binding]; other site 1144275001360 Mg2+ binding site [ion binding]; other site 1144275001361 G-X-G motif; other site 1144275001362 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1144275001363 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1144275001364 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1144275001365 ATP-binding site [chemical binding]; other site 1144275001366 Gluconate-6-phosphate binding site [chemical binding]; other site 1144275001367 B3/4 domain; Region: B3_4; cl11458 1144275001368 Cupin domain; Region: Cupin_2; cl09118 1144275001369 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1144275001370 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275001371 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001372 Walker A/P-loop; other site 1144275001373 ATP binding site [chemical binding]; other site 1144275001374 Q-loop/lid; other site 1144275001375 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275001376 ABC transporter signature motif; other site 1144275001377 Walker B; other site 1144275001378 D-loop; other site 1144275001379 ABC transporter; Region: ABC_tran_2; pfam12848 1144275001380 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275001381 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1144275001382 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1144275001383 NAD(P) binding site [chemical binding]; other site 1144275001384 catalytic residues [active] 1144275001385 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1144275001386 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1144275001387 NAD(P) binding site [chemical binding]; other site 1144275001388 catalytic residues [active] 1144275001389 Helix-turn-helix domains; Region: HTH; cl00088 1144275001390 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1144275001391 PLD-like domain; Region: PLDc_2; pfam13091 1144275001392 putative active site [active] 1144275001393 catalytic site [active] 1144275001394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001395 phosphorylation site [posttranslational modification] 1144275001396 dimer interface [polypeptide binding]; other site 1144275001397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001398 ATP binding site [chemical binding]; other site 1144275001399 G-X-G motif; other site 1144275001400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275001401 non-specific DNA binding site [nucleotide binding]; other site 1144275001402 salt bridge; other site 1144275001403 sequence-specific DNA binding site [nucleotide binding]; other site 1144275001404 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1144275001405 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1144275001406 FMN binding site [chemical binding]; other site 1144275001407 substrate binding site [chemical binding]; other site 1144275001408 putative catalytic residue [active] 1144275001409 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275001410 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1144275001411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275001412 P-loop; other site 1144275001413 Magnesium ion binding site [ion binding]; other site 1144275001414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275001415 Magnesium ion binding site [ion binding]; other site 1144275001416 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275001417 Peptidase family M48; Region: Peptidase_M48; cl12018 1144275001418 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1144275001419 CHASE2 domain; Region: CHASE2; cl01732 1144275001420 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1144275001421 cyclase homology domain; Region: CHD; cd07302 1144275001422 nucleotidyl binding site; other site 1144275001423 metal binding site [ion binding]; metal-binding site 1144275001424 dimer interface [polypeptide binding]; other site 1144275001425 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275001426 dinuclear metal binding motif [ion binding]; other site 1144275001427 TspO/MBR family; Region: TspO_MBR; cl01379 1144275001428 PAS fold; Region: PAS; pfam00989 1144275001429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275001430 putative active site [active] 1144275001431 heme pocket [chemical binding]; other site 1144275001432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275001433 PAS domain; Region: PAS_9; pfam13426 1144275001434 putative active site [active] 1144275001435 heme pocket [chemical binding]; other site 1144275001436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1144275001437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001438 dimer interface [polypeptide binding]; other site 1144275001439 phosphorylation site [posttranslational modification] 1144275001440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001441 ATP binding site [chemical binding]; other site 1144275001442 Mg2+ binding site [ion binding]; other site 1144275001443 G-X-G motif; other site 1144275001444 Predicted esterase [General function prediction only]; Region: COG0400 1144275001445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275001446 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1144275001447 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1144275001448 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275001449 Zn binding site [ion binding]; other site 1144275001450 Zn binding site [ion binding]; other site 1144275001451 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275001452 HSP70 interaction site [polypeptide binding]; other site 1144275001453 Protein of unknown function, DUF488; Region: DUF488; cl01246 1144275001454 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275001455 putative catalytic site [active] 1144275001456 putative metal binding site [ion binding]; other site 1144275001457 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275001458 putative phosphate binding site [ion binding]; other site 1144275001459 putative catalytic site [active] 1144275001460 putative phosphate binding site [ion binding]; other site 1144275001461 putative metal binding site [ion binding]; other site 1144275001462 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1144275001463 Helix-turn-helix domains; Region: HTH; cl00088 1144275001464 Helix-turn-helix domains; Region: HTH; cl00088 1144275001465 OsmC-like protein; Region: OsmC; cl00767 1144275001466 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1144275001467 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275001468 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1144275001469 Protein of unknown function (DUF433); Region: DUF433; cl01030 1144275001470 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 1144275001471 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1144275001472 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1144275001473 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1144275001474 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1144275001475 active site 1144275001476 Cupin domain; Region: Cupin_2; cl09118 1144275001477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275001478 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275001479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275001480 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1144275001481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275001482 motif II; other site 1144275001483 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1144275001484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275001485 Rhomboid family; Region: Rhomboid; cl11446 1144275001486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275001487 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1144275001488 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1144275001489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275001490 Helix-turn-helix domains; Region: HTH; cl00088 1144275001491 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275001492 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275001493 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275001494 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1144275001495 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1144275001496 DNA-binding site [nucleotide binding]; DNA binding site 1144275001497 RNA-binding motif; other site 1144275001498 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1144275001499 circadian clock protein KaiC; Reviewed; Region: PRK09302 1144275001500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001501 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001502 Walker A motif; other site 1144275001503 Walker A motif; other site 1144275001504 ATP binding site [chemical binding]; other site 1144275001505 ATP binding site [chemical binding]; other site 1144275001506 Walker B motif; other site 1144275001507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001508 Walker A motif; other site 1144275001509 ATP binding site [chemical binding]; other site 1144275001510 Walker B motif; other site 1144275001511 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001513 active site 1144275001514 phosphorylation site [posttranslational modification] 1144275001515 intermolecular recognition site; other site 1144275001516 dimerization interface [polypeptide binding]; other site 1144275001517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275001518 active site 1144275001519 catalytic tetrad [active] 1144275001520 GAF domain; Region: GAF; cl15785 1144275001521 GAF domain; Region: GAF_2; pfam13185 1144275001522 GAF domain; Region: GAF; cl15785 1144275001523 PAS fold; Region: PAS_3; pfam08447 1144275001524 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275001525 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1144275001526 GAF domain; Region: GAF; cl15785 1144275001527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001528 dimer interface [polypeptide binding]; other site 1144275001529 phosphorylation site [posttranslational modification] 1144275001530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001531 ATP binding site [chemical binding]; other site 1144275001532 Mg2+ binding site [ion binding]; other site 1144275001533 G-X-G motif; other site 1144275001534 Protein of unknown function (DUF779); Region: DUF779; cl01432 1144275001535 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1144275001536 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275001537 NAD(P) binding site [chemical binding]; other site 1144275001538 catalytic residues [active] 1144275001539 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275001540 active site 1144275001541 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275001542 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1144275001543 substrate binding site [chemical binding]; other site 1144275001544 ATP binding site [chemical binding]; other site 1144275001545 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275001546 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275001547 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275001548 active site 1144275001549 ATP binding site [chemical binding]; other site 1144275001550 substrate binding site [chemical binding]; other site 1144275001551 activation loop (A-loop); other site 1144275001552 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275001553 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001555 active site 1144275001556 phosphorylation site [posttranslational modification] 1144275001557 intermolecular recognition site; other site 1144275001558 dimerization interface [polypeptide binding]; other site 1144275001559 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275001560 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1144275001561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001562 dimer interface [polypeptide binding]; other site 1144275001563 phosphorylation site [posttranslational modification] 1144275001564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001565 ATP binding site [chemical binding]; other site 1144275001566 Mg2+ binding site [ion binding]; other site 1144275001567 G-X-G motif; other site 1144275001568 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1144275001569 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1144275001570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275001571 S-adenosylmethionine binding site [chemical binding]; other site 1144275001572 PAS fold; Region: PAS; pfam00989 1144275001573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275001574 putative active site [active] 1144275001575 heme pocket [chemical binding]; other site 1144275001576 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275001577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275001578 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1144275001579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001580 active site 1144275001581 phosphorylation site [posttranslational modification] 1144275001582 intermolecular recognition site; other site 1144275001583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275001584 DNA binding residues [nucleotide binding] 1144275001585 dimerization interface [polypeptide binding]; other site 1144275001586 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275001587 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1144275001588 O-methyltransferase; Region: Methyltransf_2; pfam00891 1144275001589 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1144275001590 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275001591 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275001592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275001593 catalytic residue [active] 1144275001594 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1144275001595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001596 active site 1144275001597 phosphorylation site [posttranslational modification] 1144275001598 intermolecular recognition site; other site 1144275001599 dimerization interface [polypeptide binding]; other site 1144275001600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275001601 active site 1144275001602 phosphorylation site [posttranslational modification] 1144275001603 intermolecular recognition site; other site 1144275001604 PAS fold; Region: PAS_4; pfam08448 1144275001605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275001606 dimer interface [polypeptide binding]; other site 1144275001607 phosphorylation site [posttranslational modification] 1144275001608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001609 ATP binding site [chemical binding]; other site 1144275001610 Mg2+ binding site [ion binding]; other site 1144275001611 G-X-G motif; other site 1144275001612 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001614 active site 1144275001615 phosphorylation site [posttranslational modification] 1144275001616 intermolecular recognition site; other site 1144275001617 dimerization interface [polypeptide binding]; other site 1144275001618 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275001619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001620 active site 1144275001621 phosphorylation site [posttranslational modification] 1144275001622 intermolecular recognition site; other site 1144275001623 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001625 active site 1144275001626 phosphorylation site [posttranslational modification] 1144275001627 intermolecular recognition site; other site 1144275001628 dimerization interface [polypeptide binding]; other site 1144275001629 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1144275001630 FIST N domain; Region: FIST; cl10701 1144275001631 FIST C domain; Region: FIST_C; pfam10442 1144275001632 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 1144275001633 PAS domain S-box; Region: sensory_box; TIGR00229 1144275001634 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275001635 GAF domain; Region: GAF; cl15785 1144275001636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275001638 ATP binding site [chemical binding]; other site 1144275001639 Mg2+ binding site [ion binding]; other site 1144275001640 G-X-G motif; other site 1144275001641 ATP-dependent helicase HepA; Validated; Region: PRK04914 1144275001642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275001643 ATP binding site [chemical binding]; other site 1144275001644 putative Mg++ binding site [ion binding]; other site 1144275001645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275001646 nucleotide binding region [chemical binding]; other site 1144275001647 ATP-binding site [chemical binding]; other site 1144275001648 TadE-like protein; Region: TadE; cl10688 1144275001649 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275001650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001651 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275001652 Walker A/P-loop; other site 1144275001653 ATP binding site [chemical binding]; other site 1144275001654 Q-loop/lid; other site 1144275001655 ABC transporter signature motif; other site 1144275001656 Walker B; other site 1144275001657 D-loop; other site 1144275001658 H-loop/switch region; other site 1144275001659 chaperone protein DnaJ; Provisional; Region: PRK10767 1144275001660 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275001661 HSP70 interaction site [polypeptide binding]; other site 1144275001662 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1144275001663 substrate binding site [polypeptide binding]; other site 1144275001664 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1144275001665 Zn binding sites [ion binding]; other site 1144275001666 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1144275001667 dimer interface [polypeptide binding]; other site 1144275001668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1144275001669 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1144275001670 putative ligand binding site [chemical binding]; other site 1144275001671 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275001672 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275001673 structural tetrad; other site 1144275001674 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1144275001675 FAD binding pocket [chemical binding]; other site 1144275001676 conserved FAD binding motif [chemical binding]; other site 1144275001677 phosphate binding motif [ion binding]; other site 1144275001678 beta-alpha-beta structure motif; other site 1144275001679 NAD binding pocket [chemical binding]; other site 1144275001680 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1144275001681 Transglycosylase; Region: Transgly; cl07896 1144275001682 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275001683 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275001684 active site 1144275001685 ATP binding site [chemical binding]; other site 1144275001686 substrate binding site [chemical binding]; other site 1144275001687 activation loop (A-loop); other site 1144275001688 Type II/IV secretion system protein; Region: T2SE; pfam00437 1144275001689 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1144275001690 ATP binding site [chemical binding]; other site 1144275001691 Walker A motif; other site 1144275001692 hexamer interface [polypeptide binding]; other site 1144275001693 Walker B motif; other site 1144275001694 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 1144275001695 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1144275001696 ligand binding site [chemical binding]; other site 1144275001697 active site 1144275001698 UGI interface [polypeptide binding]; other site 1144275001699 catalytic site [active] 1144275001700 Repair protein; Region: Repair_PSII; cl01535 1144275001701 Tim44-like domain; Region: Tim44; cl09208 1144275001702 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275001703 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1144275001704 active site 2 [active] 1144275001705 active site 1 [active] 1144275001706 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275001707 active site 2 [active] 1144275001708 active site 1 [active] 1144275001709 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275001710 putative catalytic site [active] 1144275001711 putative metal binding site [ion binding]; other site 1144275001712 putative phosphate binding site [ion binding]; other site 1144275001713 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275001714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275001715 active site 1144275001716 phosphorylation site [posttranslational modification] 1144275001717 intermolecular recognition site; other site 1144275001718 dimerization interface [polypeptide binding]; other site 1144275001719 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1144275001720 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1144275001721 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1144275001722 active site 1144275001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275001724 S-adenosylmethionine binding site [chemical binding]; other site 1144275001725 TPR repeat; Region: TPR_11; pfam13414 1144275001726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275001727 TPR motif; other site 1144275001728 DNA gyrase subunit A; Validated; Region: PRK05560 1144275001729 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1144275001730 CAP-like domain; other site 1144275001731 active site 1144275001732 primary dimer interface [polypeptide binding]; other site 1144275001733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1144275001734 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1144275001735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1144275001736 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1144275001737 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1144275001738 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1144275001739 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001740 Walker A/P-loop; other site 1144275001741 ATP binding site [chemical binding]; other site 1144275001742 Q-loop/lid; other site 1144275001743 ABC transporter signature motif; other site 1144275001744 Walker B; other site 1144275001745 D-loop; other site 1144275001746 H-loop/switch region; other site 1144275001747 TOBE domain; Region: TOBE_2; cl01440 1144275001748 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1144275001749 Scramblase; Region: Scramblase; cl02043 1144275001750 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1144275001751 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1144275001752 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275001753 metal ion-dependent adhesion site (MIDAS); other site 1144275001754 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1144275001755 DNA binding residues [nucleotide binding] 1144275001756 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1144275001757 cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926 1144275001758 active site 1144275001759 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1144275001760 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1144275001761 active site residues [active] 1144275001762 dimer interface [polypeptide binding]; other site 1144275001763 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1144275001764 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1144275001765 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1144275001766 active site 1144275001767 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1144275001768 Helix-turn-helix domains; Region: HTH; cl00088 1144275001769 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1144275001770 putative dimerization interface [polypeptide binding]; other site 1144275001771 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1144275001772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275001773 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1144275001774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275001775 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275001776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001777 Walker A/P-loop; other site 1144275001778 ATP binding site [chemical binding]; other site 1144275001779 Q-loop/lid; other site 1144275001780 ABC transporter signature motif; other site 1144275001781 Walker B; other site 1144275001782 D-loop; other site 1144275001783 H-loop/switch region; other site 1144275001784 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275001785 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275001786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275001787 Walker A/P-loop; other site 1144275001788 ATP binding site [chemical binding]; other site 1144275001789 Q-loop/lid; other site 1144275001790 ABC transporter signature motif; other site 1144275001791 Walker B; other site 1144275001792 D-loop; other site 1144275001793 H-loop/switch region; other site 1144275001794 transaminase, acetylornithine/succinylornithine family; Region: argD; TIGR00707 1144275001795 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275001796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275001797 catalytic residue [active] 1144275001798 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275001799 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275001800 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275001801 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275001802 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275001803 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275001804 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1144275001805 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275001806 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275001807 active site 1144275001808 Zn binding site [ion binding]; other site 1144275001809 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275001810 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275001811 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1144275001812 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1144275001813 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275001814 active site 1144275001815 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1144275001816 FRG domain; Region: FRG; cl07460 1144275001817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275001818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275001819 putative substrate translocation pore; other site 1144275001820 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275001821 MG2 domain; Region: A2M_N; pfam01835 1144275001822 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275001823 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1144275001824 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1144275001825 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275001826 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275001827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275001828 short chain dehydrogenase; Provisional; Region: PRK06181 1144275001829 NAD(P) binding site [chemical binding]; other site 1144275001830 active site 1144275001831 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1144275001832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275001833 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275001834 SET domain; Region: SET; cl02566 1144275001835 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1144275001836 Amidase; Region: Amidase; cl11426 1144275001837 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1144275001838 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1144275001839 ligand binding site [chemical binding]; other site 1144275001840 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1144275001841 dimer interface [polypeptide binding]; other site 1144275001842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275001843 hypothetical protein; Provisional; Region: PRK07588 1144275001844 Helix-turn-helix domains; Region: HTH; cl00088 1144275001845 DNA-binding site [nucleotide binding]; DNA binding site 1144275001846 Helix-turn-helix domains; Region: HTH; cl00088 1144275001847 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1144275001848 Flagellin N-methylase; Region: FliB; cl00497 1144275001849 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275001850 classical (c) SDRs; Region: SDR_c; cd05233 1144275001851 NAD(P) binding site [chemical binding]; other site 1144275001852 active site 1144275001853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275001854 short chain dehydrogenase; Validated; Region: PRK07069 1144275001855 NAD(P) binding site [chemical binding]; other site 1144275001856 active site 1144275001857 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275001858 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1144275001859 NADP binding site [chemical binding]; other site 1144275001860 dimer interface [polypeptide binding]; other site 1144275001861 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1144275001862 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1144275001863 Helix-turn-helix domains; Region: HTH; cl00088 1144275001864 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1144275001865 dimerization interface [polypeptide binding]; other site 1144275001866 substrate binding pocket [chemical binding]; other site 1144275001867 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1144275001868 classical (c) SDRs; Region: SDR_c; cd05233 1144275001869 NAD(P) binding site [chemical binding]; other site 1144275001870 active site 1144275001871 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1144275001872 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1144275001873 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1144275001874 putative [Fe4-S4] binding site [ion binding]; other site 1144275001875 putative molybdopterin cofactor binding site [chemical binding]; other site 1144275001876 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1144275001877 putative molybdopterin cofactor binding site; other site 1144275001878 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275001879 ligand binding site [chemical binding]; other site 1144275001880 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275001881 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275001882 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1144275001883 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275001884 N-terminal plug; other site 1144275001885 ligand-binding site [chemical binding]; other site 1144275001886 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275001887 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1144275001888 putative chaperone; Provisional; Region: PRK11678 1144275001889 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1144275001890 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1144275001891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275001892 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1144275001893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275001894 DNA binding residues [nucleotide binding] 1144275001895 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1144275001896 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1144275001897 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1144275001898 CHAD domain; Region: CHAD; cl10506 1144275001899 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1144275001900 dimer interface [polypeptide binding]; other site 1144275001901 substrate binding site [chemical binding]; other site 1144275001902 metal binding sites [ion binding]; metal-binding site 1144275001903 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 1144275001904 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 1144275001905 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1144275001906 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1144275001907 C-terminal domain interface [polypeptide binding]; other site 1144275001908 GSH binding site (G-site) [chemical binding]; other site 1144275001909 dimer interface [polypeptide binding]; other site 1144275001910 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1144275001911 dimer interface [polypeptide binding]; other site 1144275001912 N-terminal domain interface [polypeptide binding]; other site 1144275001913 short chain dehydrogenase; Provisional; Region: PRK06197 1144275001914 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1144275001915 putative NAD(P) binding site [chemical binding]; other site 1144275001916 active site 1144275001917 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1144275001918 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1144275001919 dimerization interface [polypeptide binding]; other site 1144275001920 DPS ferroxidase diiron center [ion binding]; other site 1144275001921 ion pore; other site 1144275001922 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1144275001923 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275001924 CoenzymeA binding site [chemical binding]; other site 1144275001925 subunit interaction site [polypeptide binding]; other site 1144275001926 PHB binding site; other site 1144275001927 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275001928 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1144275001929 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275001930 Peptidase S46; Region: Peptidase_S46; pfam10459 1144275001931 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275001932 cyclase homology domain; Region: CHD; cd07302 1144275001933 nucleotidyl binding site; other site 1144275001934 metal binding site [ion binding]; metal-binding site 1144275001935 dimer interface [polypeptide binding]; other site 1144275001936 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1144275001937 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275001938 putative C-terminal domain interface [polypeptide binding]; other site 1144275001939 putative GSH binding site (G-site) [chemical binding]; other site 1144275001940 putative dimer interface [polypeptide binding]; other site 1144275001941 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1144275001942 putative N-terminal domain interface [polypeptide binding]; other site 1144275001943 putative dimer interface [polypeptide binding]; other site 1144275001944 putative substrate binding pocket (H-site) [chemical binding]; other site 1144275001945 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1144275001946 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275001947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275001948 dimerization interface [polypeptide binding]; other site 1144275001949 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275001950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275001951 dimer interface [polypeptide binding]; other site 1144275001952 putative CheW interface [polypeptide binding]; other site 1144275001953 Protein required for attachment to host cells; Region: Host_attach; cl02398 1144275001954 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275001955 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275001956 active site 1144275001957 ATP binding site [chemical binding]; other site 1144275001958 substrate binding site [chemical binding]; other site 1144275001959 activation loop (A-loop); other site 1144275001960 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275001961 TPR repeat; Region: TPR_11; pfam13414 1144275001962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275001963 binding surface 1144275001964 TPR motif; other site 1144275001965 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275001966 phosphopeptide binding site; other site 1144275001967 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275001968 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275001969 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275001970 active site 1144275001971 ATP binding site [chemical binding]; other site 1144275001972 substrate binding site [chemical binding]; other site 1144275001973 activation loop (A-loop); other site 1144275001974 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275001975 Amidohydrolase; Region: Amidohydro_4; pfam13147 1144275001976 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275001977 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1144275001978 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1144275001979 generic binding surface I; other site 1144275001980 generic binding surface II; other site 1144275001981 Lamin Tail Domain; Region: LTD; pfam00932 1144275001982 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1144275001983 Helix-turn-helix domains; Region: HTH; cl00088 1144275001984 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1144275001985 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1144275001986 putative active site [active] 1144275001987 putative metal binding site [ion binding]; other site 1144275001988 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1144275001989 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1144275001990 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275001991 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1144275001992 TIGR01777 family protein; Region: yfcH 1144275001993 putative NAD(P) binding site [chemical binding]; other site 1144275001994 putative active site [active] 1144275001995 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275001996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1144275001997 substrate binding pocket [chemical binding]; other site 1144275001998 chain length determination region; other site 1144275001999 substrate-Mg2+ binding site; other site 1144275002000 catalytic residues [active] 1144275002001 aspartate-rich region 1; other site 1144275002002 active site lid residues [active] 1144275002003 aspartate-rich region 2; other site 1144275002004 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275002005 phytoene desaturase; Region: crtI_fam; TIGR02734 1144275002006 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1144275002007 active site lid residues [active] 1144275002008 substrate binding pocket [chemical binding]; other site 1144275002009 catalytic residues [active] 1144275002010 substrate-Mg2+ binding site; other site 1144275002011 aspartate-rich region 1; other site 1144275002012 aspartate-rich region 2; other site 1144275002013 phytoene desaturase; Region: crtI_fam; TIGR02734 1144275002014 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1144275002015 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1144275002016 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275002017 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1144275002018 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1144275002019 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1144275002020 putative acyl-acceptor binding pocket; other site 1144275002021 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1144275002022 DNA binding residues [nucleotide binding] 1144275002023 B12 binding domain; Region: B12-binding_2; cl03653 1144275002024 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275002025 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1144275002026 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1144275002027 DNA binding residues [nucleotide binding] 1144275002028 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275002029 B12 binding site [chemical binding]; other site 1144275002030 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1144275002031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275002032 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275002033 Cytochrome P450; Region: p450; pfam00067 1144275002034 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1144275002035 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1144275002036 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275002037 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275002038 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275002039 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275002040 active site 1144275002041 Zn binding site [ion binding]; other site 1144275002042 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275002043 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275002044 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275002045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275002046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275002047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275002048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275002049 Helix-turn-helix domains; Region: HTH; cl00088 1144275002050 Haemolysin-III related; Region: HlyIII; cl03831 1144275002051 Helix-turn-helix domains; Region: HTH; cl00088 1144275002052 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1144275002053 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1144275002054 putative NAD(P) binding site [chemical binding]; other site 1144275002055 dimer interface [polypeptide binding]; other site 1144275002056 pyruvate dehydrogenase; Provisional; Region: PRK09124 1144275002057 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1144275002058 PYR/PP interface [polypeptide binding]; other site 1144275002059 tetramer interface [polypeptide binding]; other site 1144275002060 dimer interface [polypeptide binding]; other site 1144275002061 TPP binding site [chemical binding]; other site 1144275002062 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1144275002063 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1144275002064 TPP-binding site [chemical binding]; other site 1144275002065 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275002066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275002067 DNA binding residues [nucleotide binding] 1144275002068 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1144275002069 cinnamyl-alcohol dehydrogenase; Region: PLN02514 1144275002070 putative NAD(P) binding site [chemical binding]; other site 1144275002071 putative substrate binding site [chemical binding]; other site 1144275002072 catalytic Zn binding site [ion binding]; other site 1144275002073 structural Zn binding site [ion binding]; other site 1144275002074 dimer interface [polypeptide binding]; other site 1144275002075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275002076 Helix-turn-helix domains; Region: HTH; cl00088 1144275002077 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275002078 putative effector binding pocket; other site 1144275002079 putative dimerization interface [polypeptide binding]; other site 1144275002080 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 1144275002081 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1144275002082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275002083 putative NAD(P) binding site [chemical binding]; other site 1144275002084 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275002085 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002087 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275002088 Walker A motif; other site 1144275002089 ATP binding site [chemical binding]; other site 1144275002090 Walker B motif; other site 1144275002091 arginine finger; other site 1144275002092 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1144275002093 Helix-turn-helix domains; Region: HTH; cl00088 1144275002094 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1144275002095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275002096 putative NAD(P) binding site [chemical binding]; other site 1144275002097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275002098 CoenzymeA binding site [chemical binding]; other site 1144275002099 subunit interaction site [polypeptide binding]; other site 1144275002100 PHB binding site; other site 1144275002101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1144275002102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275002103 active site 1144275002104 metal binding site [ion binding]; metal-binding site 1144275002105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275002106 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002107 active site 1144275002108 ATP binding site [chemical binding]; other site 1144275002109 substrate binding site [chemical binding]; other site 1144275002110 activation loop (A-loop); other site 1144275002111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002112 TPR motif; other site 1144275002113 binding surface 1144275002114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275002115 binding surface 1144275002116 TPR motif; other site 1144275002117 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275002118 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275002119 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275002120 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1144275002121 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1144275002122 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1144275002123 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1144275002124 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1144275002125 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1144275002126 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1144275002127 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 1144275002128 putative active site [active] 1144275002129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275002130 non-specific DNA binding site [nucleotide binding]; other site 1144275002131 salt bridge; other site 1144275002132 sequence-specific DNA binding site [nucleotide binding]; other site 1144275002133 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275002134 dinuclear metal binding motif [ion binding]; other site 1144275002135 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1144275002136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275002137 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1144275002138 putative dimer interface [polypeptide binding]; other site 1144275002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275002140 S-adenosylmethionine binding site [chemical binding]; other site 1144275002141 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275002142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275002143 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1144275002144 metal ion-dependent adhesion site (MIDAS); other site 1144275002145 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1144275002146 active site 1144275002147 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1144275002148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275002149 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1144275002150 Helix-turn-helix domains; Region: HTH; cl00088 1144275002151 hypothetical protein; Provisional; Region: PRK09133 1144275002152 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1144275002153 putative metal binding site [ion binding]; other site 1144275002154 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1144275002155 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1144275002156 active site 1144275002157 Protein of unknown function (DUF819); Region: DUF819; cl02317 1144275002158 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275002159 Nitronate monooxygenase; Region: NMO; pfam03060 1144275002160 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1144275002161 FMN binding site [chemical binding]; other site 1144275002162 substrate binding site [chemical binding]; other site 1144275002163 putative catalytic residue [active] 1144275002164 OpgC protein; Region: OpgC_C; cl00792 1144275002165 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275002166 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1144275002167 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275002168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275002169 ligand binding site [chemical binding]; other site 1144275002170 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002171 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002172 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002173 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002174 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002175 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002176 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002177 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002178 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002179 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275002180 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275002181 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002182 active site 1144275002183 ATP binding site [chemical binding]; other site 1144275002184 substrate binding site [chemical binding]; other site 1144275002185 activation loop (A-loop); other site 1144275002186 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275002187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002188 TPR motif; other site 1144275002189 binding surface 1144275002190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275002191 TPR motif; other site 1144275002192 binding surface 1144275002193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275002194 TPR motif; other site 1144275002195 binding surface 1144275002196 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275002197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002198 Walker A motif; other site 1144275002199 ATP binding site [chemical binding]; other site 1144275002200 Walker B motif; other site 1144275002201 arginine finger; other site 1144275002202 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1144275002203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275002204 motif II; other site 1144275002205 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275002206 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275002207 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275002208 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275002209 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275002210 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1144275002211 putative NAD(P) binding site [chemical binding]; other site 1144275002212 putative active site [active] 1144275002213 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1144275002214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275002215 kynureninase; Region: kynureninase; TIGR01814 1144275002216 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275002217 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275002218 catalytic residue [active] 1144275002219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275002220 Cupin domain; Region: Cupin_2; cl09118 1144275002221 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1144275002222 homotrimer interaction site [polypeptide binding]; other site 1144275002223 putative active site [active] 1144275002224 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275002225 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1144275002226 NAD binding site [chemical binding]; other site 1144275002227 catalytic residues [active] 1144275002228 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1144275002229 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1144275002230 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1144275002231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1144275002232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275002233 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1144275002234 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275002235 Helix-turn-helix domains; Region: HTH; cl00088 1144275002236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002237 dimer interface [polypeptide binding]; other site 1144275002238 phosphorylation site [posttranslational modification] 1144275002239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002240 ATP binding site [chemical binding]; other site 1144275002241 Mg2+ binding site [ion binding]; other site 1144275002242 G-X-G motif; other site 1144275002243 GLTT repeat (6 copies); Region: GLTT; pfam01744 1144275002244 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275002245 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002246 active site 1144275002247 ATP binding site [chemical binding]; other site 1144275002248 substrate binding site [chemical binding]; other site 1144275002249 activation loop (A-loop); other site 1144275002250 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275002251 phosphopeptide binding site; other site 1144275002252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275002253 PAS fold; Region: PAS_3; pfam08447 1144275002254 putative active site [active] 1144275002255 heme pocket [chemical binding]; other site 1144275002256 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275002257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275002258 putative active site [active] 1144275002259 heme pocket [chemical binding]; other site 1144275002260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002261 dimer interface [polypeptide binding]; other site 1144275002262 phosphorylation site [posttranslational modification] 1144275002263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002264 ATP binding site [chemical binding]; other site 1144275002265 Mg2+ binding site [ion binding]; other site 1144275002266 G-X-G motif; other site 1144275002267 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002269 active site 1144275002270 phosphorylation site [posttranslational modification] 1144275002271 intermolecular recognition site; other site 1144275002272 dimerization interface [polypeptide binding]; other site 1144275002273 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275002274 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275002275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002276 active site 1144275002277 ATP binding site [chemical binding]; other site 1144275002278 substrate binding site [chemical binding]; other site 1144275002279 activation loop (A-loop); other site 1144275002280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275002281 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275002282 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1144275002283 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275002284 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275002285 protein binding site [polypeptide binding]; other site 1144275002286 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275002287 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002289 active site 1144275002290 phosphorylation site [posttranslational modification] 1144275002291 intermolecular recognition site; other site 1144275002292 dimerization interface [polypeptide binding]; other site 1144275002293 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1144275002294 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1144275002295 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275002296 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275002297 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275002298 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275002299 Condensation domain; Region: Condensation; pfam00668 1144275002300 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275002301 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275002302 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275002303 acyl-CoA synthetase; Validated; Region: PRK08308 1144275002304 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275002305 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275002306 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275002307 active site 1144275002308 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275002309 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275002310 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275002311 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275002312 Thioesterase domain; Region: Thioesterase; pfam00975 1144275002313 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275002314 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1144275002315 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1144275002316 active site 1144275002317 catalytic site [active] 1144275002318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275002319 Helix-turn-helix domains; Region: HTH; cl00088 1144275002320 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1144275002321 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275002322 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275002323 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1144275002324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275002325 putative substrate translocation pore; other site 1144275002326 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1144275002327 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275002328 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275002329 putative sugar binding sites [chemical binding]; other site 1144275002330 Q-X-W motif; other site 1144275002331 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1144275002332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002333 binding surface 1144275002334 TPR motif; other site 1144275002335 CHAT domain; Region: CHAT; pfam12770 1144275002336 JmjC domain, hydroxylase; Region: JmjC; cl15814 1144275002337 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275002338 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275002339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275002340 Putative zinc-finger; Region: zf-HC2; cl15806 1144275002341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002342 binding surface 1144275002343 TPR motif; other site 1144275002344 acetyl-CoA synthetase; Provisional; Region: PRK04319 1144275002345 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275002346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275002347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275002348 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1144275002349 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1144275002350 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1144275002351 putative active site [active] 1144275002352 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1144275002353 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1144275002354 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1144275002355 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275002356 putative acyl-acceptor binding pocket; other site 1144275002357 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1144275002358 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275002359 active site 1144275002360 metal binding site [ion binding]; metal-binding site 1144275002361 DNA binding site [nucleotide binding] 1144275002362 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1144275002363 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275002364 Walker A/P-loop; other site 1144275002365 ATP binding site [chemical binding]; other site 1144275002366 Q-loop/lid; other site 1144275002367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275002368 ABC transporter signature motif; other site 1144275002369 Walker B; other site 1144275002370 D-loop; other site 1144275002371 H-loop/switch region; other site 1144275002372 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275002373 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002374 active site 1144275002375 ATP binding site [chemical binding]; other site 1144275002376 substrate binding site [chemical binding]; other site 1144275002377 activation loop (A-loop); other site 1144275002378 PilZ domain; Region: PilZ; cl01260 1144275002379 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1144275002380 putative active site [active] 1144275002381 Zn binding site [ion binding]; other site 1144275002382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275002383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002384 dimer interface [polypeptide binding]; other site 1144275002385 phosphorylation site [posttranslational modification] 1144275002386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002387 ATP binding site [chemical binding]; other site 1144275002388 Mg2+ binding site [ion binding]; other site 1144275002389 G-X-G motif; other site 1144275002390 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275002391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002392 active site 1144275002393 phosphorylation site [posttranslational modification] 1144275002394 intermolecular recognition site; other site 1144275002395 dimerization interface [polypeptide binding]; other site 1144275002396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002397 Walker B motif; other site 1144275002398 arginine finger; other site 1144275002399 Helix-turn-helix domains; Region: HTH; cl00088 1144275002400 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1144275002401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275002402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275002403 Receptor L domain; Region: Recep_L_domain; pfam01030 1144275002404 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1144275002405 Receptor L domain; Region: Recep_L_domain; pfam01030 1144275002406 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1144275002407 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1144275002408 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1144275002409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275002410 motif II; other site 1144275002411 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1144275002412 dimerization interface [polypeptide binding]; other site 1144275002413 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1144275002414 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1144275002415 iron-sulfur cluster [ion binding]; other site 1144275002416 [2Fe-2S] cluster binding site [ion binding]; other site 1144275002417 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275002418 hydrophobic ligand binding site; other site 1144275002419 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1144275002420 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1144275002421 dimer interface [polypeptide binding]; other site 1144275002422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275002423 catalytic residue [active] 1144275002424 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002426 active site 1144275002427 phosphorylation site [posttranslational modification] 1144275002428 intermolecular recognition site; other site 1144275002429 dimerization interface [polypeptide binding]; other site 1144275002430 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275002431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275002432 putative active site [active] 1144275002433 heme pocket [chemical binding]; other site 1144275002434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002435 dimer interface [polypeptide binding]; other site 1144275002436 phosphorylation site [posttranslational modification] 1144275002437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002438 ATP binding site [chemical binding]; other site 1144275002439 Mg2+ binding site [ion binding]; other site 1144275002440 G-X-G motif; other site 1144275002441 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275002442 Pirin-related protein [General function prediction only]; Region: COG1741 1144275002443 Cupin domain; Region: Cupin_2; cl09118 1144275002444 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1144275002445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275002446 PAS fold; Region: PAS_4; pfam08448 1144275002447 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1144275002448 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275002449 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1144275002450 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1144275002451 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275002452 ATP-dependent helicase; Provisional; Region: PRK13767 1144275002453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275002454 ATP binding site [chemical binding]; other site 1144275002455 putative Mg++ binding site [ion binding]; other site 1144275002456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275002457 nucleotide binding region [chemical binding]; other site 1144275002458 ATP-binding site [chemical binding]; other site 1144275002459 DEAD/H associated; Region: DEAD_assoc; pfam08494 1144275002460 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1144275002461 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1144275002462 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1144275002463 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1144275002464 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1144275002465 active site 1144275002466 dimer interface [polypeptide binding]; other site 1144275002467 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1144275002468 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1144275002469 active site 1144275002470 FMN binding site [chemical binding]; other site 1144275002471 substrate binding site [chemical binding]; other site 1144275002472 3Fe-4S cluster binding site [ion binding]; other site 1144275002473 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1144275002474 domain interface; other site 1144275002475 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1144275002476 heme binding pocket [chemical binding]; other site 1144275002477 heme ligand [chemical binding]; other site 1144275002478 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1144275002479 GAF domain; Region: GAF; cl15785 1144275002480 Phytochrome region; Region: PHY; pfam00360 1144275002481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002482 dimer interface [polypeptide binding]; other site 1144275002483 phosphorylation site [posttranslational modification] 1144275002484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002485 ATP binding site [chemical binding]; other site 1144275002486 Mg2+ binding site [ion binding]; other site 1144275002487 G-X-G motif; other site 1144275002488 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002490 active site 1144275002491 phosphorylation site [posttranslational modification] 1144275002492 intermolecular recognition site; other site 1144275002493 dimerization interface [polypeptide binding]; other site 1144275002494 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002496 active site 1144275002497 phosphorylation site [posttranslational modification] 1144275002498 intermolecular recognition site; other site 1144275002499 dimerization interface [polypeptide binding]; other site 1144275002500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002501 dimer interface [polypeptide binding]; other site 1144275002502 phosphorylation site [posttranslational modification] 1144275002503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002504 ATP binding site [chemical binding]; other site 1144275002505 Mg2+ binding site [ion binding]; other site 1144275002506 G-X-G motif; other site 1144275002507 Protein of unknown function (DUF420); Region: DUF420; cl00989 1144275002508 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1144275002509 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 1144275002510 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1144275002511 FG-GAP repeat; Region: FG-GAP; cl15299 1144275002512 EamA-like transporter family; Region: EamA; cl01037 1144275002513 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1144275002514 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1144275002515 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1144275002516 active site 1144275002517 DNA binding site [nucleotide binding] 1144275002518 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1144275002519 DNA binding site [nucleotide binding] 1144275002520 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1144275002521 nucleotide binding site [chemical binding]; other site 1144275002522 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275002523 dinuclear metal binding motif [ion binding]; other site 1144275002524 formiminoglutamate deiminase; Region: hutF; TIGR02022 1144275002525 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1144275002526 active site 1144275002527 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1144275002528 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1144275002529 metal binding site [ion binding]; metal-binding site 1144275002530 putative dimer interface [polypeptide binding]; other site 1144275002531 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1144275002532 transcription-repair coupling factor; Provisional; Region: PRK10689 1144275002533 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 1144275002534 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1144275002535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275002536 ATP binding site [chemical binding]; other site 1144275002537 putative Mg++ binding site [ion binding]; other site 1144275002538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275002539 nucleotide binding region [chemical binding]; other site 1144275002540 ATP-binding site [chemical binding]; other site 1144275002541 TRCF domain; Region: TRCF; cl04088 1144275002542 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1144275002543 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1144275002544 Cytochrome c; Region: Cytochrom_C; cl11414 1144275002545 Cytochrome c; Region: Cytochrom_C; cl11414 1144275002546 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1144275002547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275002548 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275002549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275002550 S-adenosylmethionine binding site [chemical binding]; other site 1144275002551 Chain length determinant protein; Region: Wzz; cl15801 1144275002552 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1144275002553 Chain length determinant protein; Region: Wzz; cl15801 1144275002554 Chain length determinant protein; Region: Wzz; cl15801 1144275002555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1144275002556 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275002557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275002558 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1144275002559 putative ADP-binding pocket [chemical binding]; other site 1144275002560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275002561 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275002562 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275002563 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1144275002564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275002565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275002566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275002567 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275002568 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1144275002569 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275002570 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275002571 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275002572 MatE; Region: MatE; cl10513 1144275002573 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1144275002574 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1144275002575 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1144275002576 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1144275002577 Mg++ binding site [ion binding]; other site 1144275002578 putative catalytic motif [active] 1144275002579 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1144275002580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275002581 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1144275002582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275002583 OpgC protein; Region: OpgC_C; cl00792 1144275002584 O-Antigen ligase; Region: Wzy_C; cl04850 1144275002585 O-Antigen ligase; Region: Wzy_C; cl04850 1144275002586 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275002587 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275002588 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1144275002589 putative deacylase active site [active] 1144275002590 Succinylarginine dihydrolase; Region: AstB; cl01511 1144275002591 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1144275002592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1144275002593 putative acyl-acceptor binding pocket; other site 1144275002594 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1144275002595 OstA-like protein; Region: OstA; cl00844 1144275002596 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1144275002597 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 1144275002598 Walker A/P-loop; other site 1144275002599 ATP binding site [chemical binding]; other site 1144275002600 Q-loop/lid; other site 1144275002601 ABC transporter signature motif; other site 1144275002602 Walker B; other site 1144275002603 D-loop; other site 1144275002604 H-loop/switch region; other site 1144275002605 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1144275002606 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1144275002607 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1144275002608 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1144275002609 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1144275002610 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275002611 short chain dehydrogenase; Provisional; Region: PRK06701 1144275002612 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1144275002613 NAD binding site [chemical binding]; other site 1144275002614 metal binding site [ion binding]; metal-binding site 1144275002615 active site 1144275002616 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1144275002617 30S subunit binding site; other site 1144275002618 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1144275002619 active site 1144275002620 phosphorylation site [posttranslational modification] 1144275002621 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1144275002622 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1144275002623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275002624 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1144275002625 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1144275002626 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275002627 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1144275002628 putative active site [active] 1144275002629 dimerization interface [polypeptide binding]; other site 1144275002630 putative tRNAtyr binding site [nucleotide binding]; other site 1144275002631 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1144275002632 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1144275002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275002634 dimer interface [polypeptide binding]; other site 1144275002635 conserved gate region; other site 1144275002636 putative PBP binding loops; other site 1144275002637 ABC-ATPase subunit interface; other site 1144275002638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1144275002639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275002640 dimer interface [polypeptide binding]; other site 1144275002641 conserved gate region; other site 1144275002642 putative PBP binding loops; other site 1144275002643 ABC-ATPase subunit interface; other site 1144275002644 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1144275002645 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1144275002646 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1144275002647 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275002648 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1144275002649 dimer interface [polypeptide binding]; other site 1144275002650 ssDNA binding site [nucleotide binding]; other site 1144275002651 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1144275002652 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1144275002653 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1144275002654 Iron-sulfur protein interface; other site 1144275002655 proximal heme binding site [chemical binding]; other site 1144275002656 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1144275002657 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1144275002658 dimerization interface [polypeptide binding]; other site 1144275002659 domain crossover interface; other site 1144275002660 redox-dependent activation switch; other site 1144275002661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275002662 active site 1144275002663 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1144275002664 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1144275002665 G1 box; other site 1144275002666 putative GEF interaction site [polypeptide binding]; other site 1144275002667 GTP/Mg2+ binding site [chemical binding]; other site 1144275002668 Switch I region; other site 1144275002669 G2 box; other site 1144275002670 G3 box; other site 1144275002671 Switch II region; other site 1144275002672 G4 box; other site 1144275002673 G5 box; other site 1144275002674 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1144275002675 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1144275002676 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1144275002677 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1144275002678 PAS fold; Region: PAS; pfam00989 1144275002679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275002680 putative active site [active] 1144275002681 heme pocket [chemical binding]; other site 1144275002682 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275002683 GAF domain; Region: GAF; cl15785 1144275002684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002685 dimer interface [polypeptide binding]; other site 1144275002686 phosphorylation site [posttranslational modification] 1144275002687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002688 ATP binding site [chemical binding]; other site 1144275002689 Mg2+ binding site [ion binding]; other site 1144275002690 G-X-G motif; other site 1144275002691 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275002692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002693 active site 1144275002694 phosphorylation site [posttranslational modification] 1144275002695 intermolecular recognition site; other site 1144275002696 dimerization interface [polypeptide binding]; other site 1144275002697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002698 Walker A motif; other site 1144275002699 ATP binding site [chemical binding]; other site 1144275002700 Walker B motif; other site 1144275002701 Helix-turn-helix domains; Region: HTH; cl00088 1144275002702 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1144275002703 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1144275002704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1144275002705 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1144275002706 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1144275002707 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1144275002708 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1144275002709 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1144275002710 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 1144275002711 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1144275002712 SLBB domain; Region: SLBB; pfam10531 1144275002713 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 1144275002714 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1144275002715 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1144275002716 putative dimer interface [polypeptide binding]; other site 1144275002717 [2Fe-2S] cluster binding site [ion binding]; other site 1144275002718 PilZ domain; Region: PilZ; cl01260 1144275002719 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002721 active site 1144275002722 phosphorylation site [posttranslational modification] 1144275002723 intermolecular recognition site; other site 1144275002724 dimerization interface [polypeptide binding]; other site 1144275002725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002726 active site 1144275002727 ATP binding site [chemical binding]; other site 1144275002728 substrate binding site [chemical binding]; other site 1144275002729 activation loop (A-loop); other site 1144275002730 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275002731 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1144275002732 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1144275002733 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1144275002734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275002735 motif II; other site 1144275002736 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275002737 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1144275002738 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1144275002739 putative dimer interface [polypeptide binding]; other site 1144275002740 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1144275002741 DNA binding residues [nucleotide binding] 1144275002742 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275002743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002744 active site 1144275002745 phosphorylation site [posttranslational modification] 1144275002746 intermolecular recognition site; other site 1144275002747 dimerization interface [polypeptide binding]; other site 1144275002748 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 1144275002749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275002750 active site 1144275002751 motif I; other site 1144275002752 motif II; other site 1144275002753 NeuB family; Region: NeuB; cl00496 1144275002754 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1144275002755 CTP synthetase; Validated; Region: pyrG; PRK05380 1144275002756 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1144275002757 Catalytic site [active] 1144275002758 active site 1144275002759 UTP binding site [chemical binding]; other site 1144275002760 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1144275002761 active site 1144275002762 putative oxyanion hole; other site 1144275002763 catalytic triad [active] 1144275002764 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1144275002765 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275002766 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1144275002767 Walker A/P-loop; other site 1144275002768 ATP binding site [chemical binding]; other site 1144275002769 Q-loop/lid; other site 1144275002770 ABC transporter signature motif; other site 1144275002771 Walker B; other site 1144275002772 D-loop; other site 1144275002773 H-loop/switch region; other site 1144275002774 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275002775 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1144275002776 active site 1144275002777 catalytic tetrad [active] 1144275002778 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1144275002779 Ligand binding site; other site 1144275002780 oligomer interface; other site 1144275002781 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1144275002782 active site 1144275002783 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1144275002784 homodimer interface [polypeptide binding]; other site 1144275002785 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1144275002786 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275002787 active site 1144275002788 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1144275002789 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275002790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275002791 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1144275002792 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275002793 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1144275002794 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275002795 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275002796 Outer membrane efflux protein; Region: OEP; pfam02321 1144275002797 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275002798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002799 active site 1144275002800 phosphorylation site [posttranslational modification] 1144275002801 intermolecular recognition site; other site 1144275002802 dimerization interface [polypeptide binding]; other site 1144275002803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002804 Walker A motif; other site 1144275002805 ATP binding site [chemical binding]; other site 1144275002806 Walker B motif; other site 1144275002807 arginine finger; other site 1144275002808 Helix-turn-helix domains; Region: HTH; cl00088 1144275002809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275002810 dimer interface [polypeptide binding]; other site 1144275002811 phosphorylation site [posttranslational modification] 1144275002812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002813 ATP binding site [chemical binding]; other site 1144275002814 Mg2+ binding site [ion binding]; other site 1144275002815 G-X-G motif; other site 1144275002816 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1144275002817 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1144275002818 active site 1144275002819 tetramer interface [polypeptide binding]; other site 1144275002820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275002821 active site 1144275002822 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1144275002823 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1144275002824 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 1144275002825 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 1144275002826 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 1144275002827 Cytochrome c; Region: Cytochrom_C; cl11414 1144275002828 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1144275002829 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1144275002830 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1144275002831 active site 1144275002832 catalytic residues [active] 1144275002833 hydroperoxidase II; Provisional; Region: katE; PRK11249 1144275002834 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1144275002835 tetramer interface [polypeptide binding]; other site 1144275002836 heme binding pocket [chemical binding]; other site 1144275002837 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1144275002838 domain interactions; other site 1144275002839 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1144275002840 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1144275002841 NAD(P) binding site [chemical binding]; other site 1144275002842 substrate binding site [chemical binding]; other site 1144275002843 dimer interface [polypeptide binding]; other site 1144275002844 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275002845 putative active site [active] 1144275002846 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275002847 putative active site [active] 1144275002848 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1144275002849 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1144275002850 putative active site [active] 1144275002851 putative metal binding site [ion binding]; other site 1144275002852 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275002853 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275002854 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1144275002855 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275002856 HSP70 interaction site [polypeptide binding]; other site 1144275002857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002858 binding surface 1144275002859 TPR motif; other site 1144275002860 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1144275002861 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1144275002862 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1144275002863 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1144275002864 carboxyltransferase (CT) interaction site; other site 1144275002865 biotinylation site [posttranslational modification]; other site 1144275002866 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1144275002867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1144275002868 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1144275002869 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1144275002870 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275002871 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275002872 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1144275002873 active site 1144275002874 putative substrate binding region [chemical binding]; other site 1144275002875 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1144275002876 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275002877 Clostridial hydrophobic W; Region: ChW; cl02763 1144275002878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275002879 S-adenosylmethionine binding site [chemical binding]; other site 1144275002880 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1144275002881 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1144275002882 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1144275002883 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275002884 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275002885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002886 active site 1144275002887 phosphorylation site [posttranslational modification] 1144275002888 intermolecular recognition site; other site 1144275002889 dimerization interface [polypeptide binding]; other site 1144275002890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002891 Walker A motif; other site 1144275002892 ATP binding site [chemical binding]; other site 1144275002893 Walker B motif; other site 1144275002894 arginine finger; other site 1144275002895 Helix-turn-helix domains; Region: HTH; cl00088 1144275002896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002897 dimer interface [polypeptide binding]; other site 1144275002898 phosphorylation site [posttranslational modification] 1144275002899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002900 ATP binding site [chemical binding]; other site 1144275002901 Mg2+ binding site [ion binding]; other site 1144275002902 G-X-G motif; other site 1144275002903 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275002904 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1144275002905 RDD family; Region: RDD; cl00746 1144275002906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1144275002907 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1144275002908 L-asparaginase II; Region: Asparaginase_II; cl01842 1144275002909 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1144275002910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275002911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275002912 S-adenosylmethionine binding site [chemical binding]; other site 1144275002913 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275002914 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275002915 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275002916 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275002917 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275002918 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275002919 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275002920 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1144275002921 HemN C-terminal domain; Region: HemN_C; pfam06969 1144275002922 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275002923 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275002924 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1144275002925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002926 binding surface 1144275002927 TPR motif; other site 1144275002928 TadE-like protein; Region: TadE; cl10688 1144275002929 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1144275002930 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1144275002931 putative ligand binding site [chemical binding]; other site 1144275002932 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1144275002933 Helix-turn-helix domains; Region: HTH; cl00088 1144275002934 Helix-turn-helix domains; Region: HTH; cl00088 1144275002935 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1144275002936 putative ABC transporter; Region: ycf24; CHL00085 1144275002937 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1144275002938 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1144275002939 Walker A/P-loop; other site 1144275002940 ATP binding site [chemical binding]; other site 1144275002941 Q-loop/lid; other site 1144275002942 ABC transporter signature motif; other site 1144275002943 Walker B; other site 1144275002944 D-loop; other site 1144275002945 H-loop/switch region; other site 1144275002946 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1144275002947 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1144275002948 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1144275002949 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1144275002950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275002951 catalytic residue [active] 1144275002952 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1144275002953 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1144275002954 trimerization site [polypeptide binding]; other site 1144275002955 active site 1144275002956 Domain of unknown function DUF59; Region: DUF59; cl00941 1144275002957 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1144275002958 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1144275002959 proposed catalytic triad [active] 1144275002960 conserved cys residue [active] 1144275002961 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1144275002962 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1144275002963 catalytic nucleophile [active] 1144275002964 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275002965 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275002966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275002967 binding surface 1144275002968 TPR motif; other site 1144275002969 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1144275002970 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 1144275002971 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275002972 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275002973 active site 1144275002974 ATP binding site [chemical binding]; other site 1144275002975 substrate binding site [chemical binding]; other site 1144275002976 activation loop (A-loop); other site 1144275002977 GAF domain; Region: GAF; cl15785 1144275002978 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1144275002979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275002980 dimer interface [polypeptide binding]; other site 1144275002981 phosphorylation site [posttranslational modification] 1144275002982 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1144275002983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275002984 ATP binding site [chemical binding]; other site 1144275002985 Mg2+ binding site [ion binding]; other site 1144275002986 G-X-G motif; other site 1144275002987 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275002988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275002989 active site 1144275002990 phosphorylation site [posttranslational modification] 1144275002991 intermolecular recognition site; other site 1144275002992 dimerization interface [polypeptide binding]; other site 1144275002993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275002994 Walker A motif; other site 1144275002995 ATP binding site [chemical binding]; other site 1144275002996 Walker B motif; other site 1144275002997 arginine finger; other site 1144275002998 Helix-turn-helix domains; Region: HTH; cl00088 1144275002999 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1144275003000 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1144275003001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003002 Helix-turn-helix domains; Region: HTH; cl00088 1144275003003 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1144275003004 Predicted esterase [General function prediction only]; Region: COG0400 1144275003005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275003006 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1144275003007 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1144275003008 active site 1144275003009 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1144275003010 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1144275003011 primosome assembly protein PriA; Provisional; Region: PRK14873 1144275003012 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1144275003013 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1144275003014 spermidine synthase; Provisional; Region: PRK03612 1144275003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275003016 S-adenosylmethionine binding site [chemical binding]; other site 1144275003017 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1144275003018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003019 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1144275003020 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275003021 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275003022 catalytic residue [active] 1144275003023 Cupin domain; Region: Cupin_2; cl09118 1144275003024 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1144275003025 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1144275003026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003027 TPR motif; other site 1144275003028 binding surface 1144275003029 TPR repeat; Region: TPR_11; pfam13414 1144275003030 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 1144275003031 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1144275003032 active site 1144275003033 homotetramer interface [polypeptide binding]; other site 1144275003034 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275003035 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275003036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003037 binding surface 1144275003038 TPR motif; other site 1144275003039 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1144275003040 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1144275003041 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 1144275003042 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275003043 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275003044 Glyco_18 domain; Region: Glyco_18; smart00636 1144275003045 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1144275003046 active site 1144275003047 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1144275003048 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1144275003049 active site 1144275003050 dimer interface [polypeptide binding]; other site 1144275003051 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1144275003052 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1144275003053 dimer interface [polypeptide binding]; other site 1144275003054 active site 1144275003055 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1144275003056 dimer interface [polypeptide binding]; other site 1144275003057 active site 1144275003058 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1144275003059 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275003060 putative active site [active] 1144275003061 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1144275003062 hypothetical protein; Reviewed; Region: PRK09588 1144275003063 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1144275003064 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1144275003065 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1144275003066 Oligomerisation domain; Region: Oligomerisation; cl00519 1144275003067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003068 TPR motif; other site 1144275003069 TPR repeat; Region: TPR_11; pfam13414 1144275003070 binding surface 1144275003071 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275003072 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275003073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275003074 active site 1144275003075 phosphorylation site [posttranslational modification] 1144275003076 intermolecular recognition site; other site 1144275003077 dimerization interface [polypeptide binding]; other site 1144275003078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275003079 Walker A motif; other site 1144275003080 ATP binding site [chemical binding]; other site 1144275003081 Walker B motif; other site 1144275003082 arginine finger; other site 1144275003083 Helix-turn-helix domains; Region: HTH; cl00088 1144275003084 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1144275003085 nudix motif; other site 1144275003086 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1144275003087 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1144275003088 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1144275003089 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275003090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275003091 dimer interface [polypeptide binding]; other site 1144275003092 putative CheW interface [polypeptide binding]; other site 1144275003093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275003094 dimerization interface [polypeptide binding]; other site 1144275003095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275003096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275003097 dimer interface [polypeptide binding]; other site 1144275003098 phosphorylation site [posttranslational modification] 1144275003099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275003100 ATP binding site [chemical binding]; other site 1144275003101 Mg2+ binding site [ion binding]; other site 1144275003102 G-X-G motif; other site 1144275003103 DNA repair protein RadA; Provisional; Region: PRK11823 1144275003104 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1144275003105 Walker A motif/ATP binding site; other site 1144275003106 ATP binding site [chemical binding]; other site 1144275003107 Walker B motif; other site 1144275003108 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1144275003109 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1144275003110 biotin synthase; Region: bioB; TIGR00433 1144275003111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275003112 FeS/SAM binding site; other site 1144275003113 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1144275003114 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1144275003115 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1144275003116 substrate-cofactor binding pocket; other site 1144275003117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275003118 catalytic residue [active] 1144275003119 AAA domain; Region: AAA_26; pfam13500 1144275003120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003122 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1144275003123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275003124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275003125 homodimer interface [polypeptide binding]; other site 1144275003126 catalytic residue [active] 1144275003127 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1144275003128 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 1144275003129 ligand binding site [chemical binding]; other site 1144275003130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003131 binding surface 1144275003132 TPR motif; other site 1144275003133 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1144275003134 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 1144275003135 active site 1144275003136 substrate-binding site [chemical binding]; other site 1144275003137 metal-binding site [ion binding] 1144275003138 GTP binding site [chemical binding]; other site 1144275003139 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275003140 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275003141 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275003142 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275003143 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1144275003144 active site 1144275003145 dinuclear metal binding site [ion binding]; other site 1144275003146 dimerization interface [polypeptide binding]; other site 1144275003147 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1144275003148 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1144275003149 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1144275003150 active site 1144275003151 HIGH motif; other site 1144275003152 KMSKS motif; other site 1144275003153 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275003154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275003155 active site 1144275003156 metal binding site [ion binding]; metal-binding site 1144275003157 cyclase homology domain; Region: CHD; cd07302 1144275003158 nucleotidyl binding site; other site 1144275003159 metal binding site [ion binding]; metal-binding site 1144275003160 dimer interface [polypeptide binding]; other site 1144275003161 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1144275003162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275003163 FeS/SAM binding site; other site 1144275003164 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1144275003165 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1144275003166 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1144275003167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275003168 active site 1144275003169 phosphorylation site [posttranslational modification] 1144275003170 intermolecular recognition site; other site 1144275003171 dimerization interface [polypeptide binding]; other site 1144275003172 LytTr DNA-binding domain; Region: LytTR; cl04498 1144275003173 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1144275003174 Histidine kinase; Region: His_kinase; pfam06580 1144275003175 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1144275003176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003177 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1144275003178 NADP binding site [chemical binding]; other site 1144275003179 homodimer interface [polypeptide binding]; other site 1144275003180 active site 1144275003181 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003182 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1144275003183 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1144275003184 putative active site [active] 1144275003185 putative metal binding site [ion binding]; other site 1144275003186 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1144275003187 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1144275003188 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1144275003189 glycogen synthase; Provisional; Region: glgA; PRK00654 1144275003190 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1144275003191 ADP-binding pocket [chemical binding]; other site 1144275003192 homodimer interface [polypeptide binding]; other site 1144275003193 Protein kinase domain; Region: Pkinase; pfam00069 1144275003194 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275003195 active site 1144275003196 ATP binding site [chemical binding]; other site 1144275003197 substrate binding site [chemical binding]; other site 1144275003198 activation loop (A-loop); other site 1144275003199 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1144275003200 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1144275003201 Domain of unknown function DUF21; Region: DUF21; pfam01595 1144275003202 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1144275003203 Transporter associated domain; Region: CorC_HlyC; cl08393 1144275003204 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1144275003205 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1144275003206 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1144275003207 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275003208 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1144275003209 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1144275003210 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275003211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275003212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003213 binding surface 1144275003214 TPR motif; other site 1144275003215 TPR repeat; Region: TPR_11; pfam13414 1144275003216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003217 binding surface 1144275003218 TPR motif; other site 1144275003219 TPR repeat; Region: TPR_11; pfam13414 1144275003220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003221 binding surface 1144275003222 TPR repeat; Region: TPR_11; pfam13414 1144275003223 TPR motif; other site 1144275003224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003225 TPR motif; other site 1144275003226 binding surface 1144275003227 Outer membrane lipoprotein; Region: YfiO; pfam13525 1144275003228 TPR repeat; Region: TPR_11; pfam13414 1144275003229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003230 binding surface 1144275003231 TPR motif; other site 1144275003232 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1144275003233 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1144275003234 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1144275003235 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1144275003236 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1144275003237 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275003238 metal ion-dependent adhesion site (MIDAS); other site 1144275003239 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275003240 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275003241 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275003242 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1144275003243 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 1144275003244 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275003245 phosphopeptide binding site; other site 1144275003246 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275003247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275003248 Walker A motif; other site 1144275003249 ATP binding site [chemical binding]; other site 1144275003250 Walker B motif; other site 1144275003251 arginine finger; other site 1144275003252 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275003253 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275003254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275003255 S-adenosylmethionine binding site [chemical binding]; other site 1144275003256 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275003257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275003258 active site 1144275003259 phosphorylation site [posttranslational modification] 1144275003260 intermolecular recognition site; other site 1144275003261 dimerization interface [polypeptide binding]; other site 1144275003262 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275003263 DNA binding site [nucleotide binding] 1144275003264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275003265 dimer interface [polypeptide binding]; other site 1144275003266 phosphorylation site [posttranslational modification] 1144275003267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275003268 ATP binding site [chemical binding]; other site 1144275003269 Mg2+ binding site [ion binding]; other site 1144275003270 G-X-G motif; other site 1144275003271 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1144275003272 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1144275003273 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1144275003274 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1144275003275 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1144275003276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003277 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1144275003278 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1144275003279 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1144275003280 HflX GTPase family; Region: HflX; cd01878 1144275003281 G1 box; other site 1144275003282 GTP/Mg2+ binding site [chemical binding]; other site 1144275003283 Switch I region; other site 1144275003284 G2 box; other site 1144275003285 G3 box; other site 1144275003286 Switch II region; other site 1144275003287 G4 box; other site 1144275003288 G5 box; other site 1144275003289 gamma-glutamyl kinase; Provisional; Region: PRK05429 1144275003290 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1144275003291 nucleotide binding site [chemical binding]; other site 1144275003292 homotetrameric interface [polypeptide binding]; other site 1144275003293 putative phosphate binding site [ion binding]; other site 1144275003294 putative allosteric binding site; other site 1144275003295 PUA domain; Region: PUA; cl00607 1144275003296 Predicted transcriptional regulator [Transcription]; Region: COG2378 1144275003297 WYL domain; Region: WYL; cl14852 1144275003298 Predicted transcriptional regulator [Transcription]; Region: COG2378 1144275003299 WYL domain; Region: WYL; cl14852 1144275003300 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275003301 phosphopeptide binding site; other site 1144275003302 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1144275003303 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1144275003304 putative active site [active] 1144275003305 catalytic site [active] 1144275003306 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1144275003307 putative active site [active] 1144275003308 catalytic site [active] 1144275003309 aconitate hydratase; Validated; Region: PRK09277 1144275003310 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1144275003311 substrate binding site [chemical binding]; other site 1144275003312 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1144275003313 ligand binding site [chemical binding]; other site 1144275003314 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1144275003315 substrate binding site [chemical binding]; other site 1144275003316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275003317 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1144275003318 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1144275003319 RF-1 domain; Region: RF-1; cl02875 1144275003320 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1144275003321 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275003322 metal ion-dependent adhesion site (MIDAS); other site 1144275003323 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1144275003324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003325 Walker A/P-loop; other site 1144275003326 ATP binding site [chemical binding]; other site 1144275003327 Q-loop/lid; other site 1144275003328 ABC transporter signature motif; other site 1144275003329 Walker B; other site 1144275003330 D-loop; other site 1144275003331 H-loop/switch region; other site 1144275003332 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275003333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275003334 active site 1144275003335 phosphorylation site [posttranslational modification] 1144275003336 intermolecular recognition site; other site 1144275003337 dimerization interface [polypeptide binding]; other site 1144275003338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1144275003339 active site 1144275003340 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275003341 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1144275003342 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1144275003343 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1144275003344 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1144275003345 Substrate binding site; other site 1144275003346 Mg++ binding site; other site 1144275003347 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1144275003348 active site 1144275003349 substrate binding site [chemical binding]; other site 1144275003350 CoA binding site [chemical binding]; other site 1144275003351 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1144275003352 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1144275003353 glutaminase active site [active] 1144275003354 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1144275003355 dimer interface [polypeptide binding]; other site 1144275003356 active site 1144275003357 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1144275003358 dimer interface [polypeptide binding]; other site 1144275003359 active site 1144275003360 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1144275003361 Putative zinc-finger; Region: zf-HC2; cl15806 1144275003362 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1144275003363 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275003364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275003365 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275003366 DNA binding residues [nucleotide binding] 1144275003367 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1144275003368 protein RecA; Region: tigrfam_recA; TIGR02012 1144275003369 hexamer interface [polypeptide binding]; other site 1144275003370 Walker A motif; other site 1144275003371 ATP binding site [chemical binding]; other site 1144275003372 Walker B motif; other site 1144275003373 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1144275003374 putative active site [active] 1144275003375 putative metal binding site [ion binding]; other site 1144275003376 PhoD-like phosphatase; Region: PhoD; pfam09423 1144275003377 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275003378 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003379 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003380 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003381 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003382 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003383 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003384 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003385 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003386 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1144275003387 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275003388 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275003389 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1144275003390 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275003391 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1144275003392 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1144275003393 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1144275003394 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1144275003395 RNA binding site [nucleotide binding]; other site 1144275003396 HSP90 family protein; Provisional; Region: PRK14083 1144275003397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275003398 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275003399 hypothetical protein; Provisional; Region: PRK06184 1144275003400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003402 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275003403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275003404 Helix-turn-helix domains; Region: HTH; cl00088 1144275003405 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275003406 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275003407 active site 1144275003408 catalytic tetrad [active] 1144275003409 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1144275003410 classical (c) SDRs; Region: SDR_c; cd05233 1144275003411 NAD(P) binding site [chemical binding]; other site 1144275003412 active site 1144275003413 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275003414 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275003415 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1144275003416 Walker A/P-loop; other site 1144275003417 ATP binding site [chemical binding]; other site 1144275003418 Q-loop/lid; other site 1144275003419 ABC transporter signature motif; other site 1144275003420 Walker B; other site 1144275003421 D-loop; other site 1144275003422 H-loop/switch region; other site 1144275003423 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275003424 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275003425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003426 Walker A/P-loop; other site 1144275003427 ATP binding site [chemical binding]; other site 1144275003428 Q-loop/lid; other site 1144275003429 ABC transporter signature motif; other site 1144275003430 Walker B; other site 1144275003431 D-loop; other site 1144275003432 H-loop/switch region; other site 1144275003433 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275003434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275003435 active site 1144275003436 catalytic tetrad [active] 1144275003437 Sulfatase; Region: Sulfatase; cl10460 1144275003438 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1144275003439 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275003440 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1144275003441 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275003442 active site 1144275003443 Zn binding site [ion binding]; other site 1144275003444 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1144275003445 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1144275003446 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1144275003447 RNA binding surface [nucleotide binding]; other site 1144275003448 Predicted membrane protein [Function unknown]; Region: COG1289 1144275003449 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1144275003450 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1144275003451 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1144275003452 HEAT repeats; Region: HEAT_2; pfam13646 1144275003453 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1144275003454 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1144275003455 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1144275003456 putative active site [active] 1144275003457 substrate binding site [chemical binding]; other site 1144275003458 putative cosubstrate binding site; other site 1144275003459 catalytic site [active] 1144275003460 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1144275003461 substrate binding site [chemical binding]; other site 1144275003462 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1144275003463 trimer interface [polypeptide binding]; other site 1144275003464 active site 1144275003465 dimer interface [polypeptide binding]; other site 1144275003466 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1144275003467 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1144275003468 putative RNA binding site [nucleotide binding]; other site 1144275003469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275003470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275003471 Helix-turn-helix domains; Region: HTH; cl00088 1144275003472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1144275003473 dimerization interface [polypeptide binding]; other site 1144275003474 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1144275003475 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275003476 classical (c) SDRs; Region: SDR_c; cd05233 1144275003477 NAD(P) binding site [chemical binding]; other site 1144275003478 active site 1144275003479 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1144275003480 catalytic residues [active] 1144275003481 transaminase; Validated; Region: PRK07324 1144275003482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275003483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275003484 homodimer interface [polypeptide binding]; other site 1144275003485 catalytic residue [active] 1144275003486 TIGR03503 family protein; Region: TIGR03503 1144275003487 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1144275003488 Protein phosphatase 2C; Region: PP2C; pfam00481 1144275003489 active site 1144275003490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275003491 dimerization interface [polypeptide binding]; other site 1144275003492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275003493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275003494 dimer interface [polypeptide binding]; other site 1144275003495 putative CheW interface [polypeptide binding]; other site 1144275003496 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275003497 classical (c) SDRs; Region: SDR_c; cd05233 1144275003498 NAD(P) binding site [chemical binding]; other site 1144275003499 active site 1144275003500 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1144275003501 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1144275003502 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1144275003503 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1144275003504 acyl-coenzyme A oxidase; Region: PLN02526 1144275003505 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275003506 active site 1144275003507 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 1144275003508 active site 1144275003509 Zn binding site [ion binding]; other site 1144275003510 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1144275003511 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275003512 active site 1144275003513 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1144275003514 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1144275003515 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1144275003516 active site 1144275003517 tetramer interface; other site 1144275003518 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275003519 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 1144275003520 C-terminal domain interface [polypeptide binding]; other site 1144275003521 GSH binding site (G-site) [chemical binding]; other site 1144275003522 dimer interface [polypeptide binding]; other site 1144275003523 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275003524 N-terminal domain interface [polypeptide binding]; other site 1144275003525 dimer interface [polypeptide binding]; other site 1144275003526 substrate binding pocket (H-site) [chemical binding]; other site 1144275003527 primosome assembly protein PriA; Validated; Region: PRK05580 1144275003528 primosome assembly protein PriA; Validated; Region: PRK05580 1144275003529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275003530 ATP binding site [chemical binding]; other site 1144275003531 putative Mg++ binding site [ion binding]; other site 1144275003532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003533 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1144275003534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275003535 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275003536 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1144275003537 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1144275003538 active site 1144275003539 catalytic residues [active] 1144275003540 metal binding site [ion binding]; metal-binding site 1144275003541 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1144275003542 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1144275003543 minor groove reading motif; other site 1144275003544 helix-hairpin-helix signature motif; other site 1144275003545 substrate binding pocket [chemical binding]; other site 1144275003546 active site 1144275003547 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1144275003548 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1144275003549 tetramer interface [polypeptide binding]; other site 1144275003550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275003551 catalytic residue [active] 1144275003552 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275003553 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1144275003554 IHF dimer interface [polypeptide binding]; other site 1144275003555 IHF - DNA interface [nucleotide binding]; other site 1144275003556 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275003557 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275003558 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1144275003559 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1144275003560 competence damage-inducible protein A; Provisional; Region: PRK00549 1144275003561 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1144275003562 putative MPT binding site; other site 1144275003563 Competence-damaged protein; Region: CinA; cl00666 1144275003564 Protein of unknown function (DUF1285); Region: DUF1285; cl01571 1144275003565 recombinase A; Provisional; Region: recA; PRK09354 1144275003566 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1144275003567 hexamer interface [polypeptide binding]; other site 1144275003568 Walker A motif; other site 1144275003569 ATP binding site [chemical binding]; other site 1144275003570 Walker B motif; other site 1144275003571 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1144275003572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275003574 Mg chelatase-related protein; Region: TIGR00368 1144275003575 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1144275003576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003577 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1144275003578 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275003579 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275003580 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275003581 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275003582 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003583 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275003584 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1144275003585 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275003586 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1144275003587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275003588 FeS/SAM binding site; other site 1144275003589 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1144275003590 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1144275003591 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1144275003592 THUMP domain; Region: THUMP; cl12076 1144275003593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275003594 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1144275003595 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1144275003596 DNA translocase FtsK; Provisional; Region: PRK10263 1144275003597 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003599 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1144275003600 EAP30/Vps36 family; Region: EAP30; pfam04157 1144275003601 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1144275003602 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1144275003603 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1144275003604 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1144275003605 Amidase; Region: Amidase; cl11426 1144275003606 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1144275003607 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1144275003608 GatB domain; Region: GatB_Yqey; cl11497 1144275003609 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1144275003610 active site 1144275003611 catalytic triad [active] 1144275003612 dimer interface [polypeptide binding]; other site 1144275003613 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1144275003614 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 1144275003615 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275003616 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275003617 active site 1144275003618 ATP binding site [chemical binding]; other site 1144275003619 substrate binding site [chemical binding]; other site 1144275003620 activation loop (A-loop); other site 1144275003621 PilZ domain; Region: PilZ; cl01260 1144275003622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275003623 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1144275003624 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1144275003625 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1144275003626 GTP1/OBG; Region: GTP1_OBG; pfam01018 1144275003627 Obg GTPase; Region: Obg; cd01898 1144275003628 G1 box; other site 1144275003629 GTP/Mg2+ binding site [chemical binding]; other site 1144275003630 Switch I region; other site 1144275003631 G2 box; other site 1144275003632 G3 box; other site 1144275003633 Switch II region; other site 1144275003634 G4 box; other site 1144275003635 G5 box; other site 1144275003636 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1144275003637 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1144275003638 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1144275003639 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1144275003640 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1144275003641 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275003642 FeS/SAM binding site; other site 1144275003643 TRAM domain; Region: TRAM; cl01282 1144275003644 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1144275003645 Protein of unknown function (DUF520); Region: DUF520; cl00723 1144275003646 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1144275003647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275003648 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1144275003649 Helix-turn-helix domains; Region: HTH; cl00088 1144275003650 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 1144275003651 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275003652 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275003653 catalytic residue [active] 1144275003654 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1144275003655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275003656 Walker A motif; other site 1144275003657 ATP binding site [chemical binding]; other site 1144275003658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275003659 Walker A motif; other site 1144275003660 ATP binding site [chemical binding]; other site 1144275003661 Walker B motif; other site 1144275003662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275003663 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1144275003664 RF-1 domain; Region: RF-1; cl02875 1144275003665 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1144275003666 active site 1144275003667 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275003668 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1144275003669 NADP binding site [chemical binding]; other site 1144275003670 dimer interface [polypeptide binding]; other site 1144275003671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275003672 putative substrate translocation pore; other site 1144275003673 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1144275003674 Helix-turn-helix domains; Region: HTH; cl00088 1144275003675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275003676 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1144275003677 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1144275003678 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275003679 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1144275003680 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1144275003681 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 1144275003682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275003683 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 1144275003684 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1144275003685 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1144275003686 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1144275003687 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275003688 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275003689 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1144275003690 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275003691 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275003692 putative sugar binding sites [chemical binding]; other site 1144275003693 Q-X-W motif; other site 1144275003694 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1144275003695 putative sugar binding site [chemical binding]; other site 1144275003696 catalytic residues [active] 1144275003697 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1144275003698 conserved cys residue [active] 1144275003699 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275003701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275003702 active site 1144275003703 phosphorylation site [posttranslational modification] 1144275003704 intermolecular recognition site; other site 1144275003705 dimerization interface [polypeptide binding]; other site 1144275003706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275003707 DNA binding site [nucleotide binding] 1144275003708 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275003709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275003710 dimer interface [polypeptide binding]; other site 1144275003711 phosphorylation site [posttranslational modification] 1144275003712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275003713 ATP binding site [chemical binding]; other site 1144275003714 G-X-G motif; other site 1144275003715 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003716 von Willebrand factor; Region: vWF_A; pfam12450 1144275003717 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1144275003718 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1144275003719 metal ion-dependent adhesion site (MIDAS); other site 1144275003720 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1144275003721 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1144275003722 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275003723 tetrameric interface [polypeptide binding]; other site 1144275003724 activator binding site; other site 1144275003725 NADP binding site [chemical binding]; other site 1144275003726 substrate binding site [chemical binding]; other site 1144275003727 catalytic residues [active] 1144275003728 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1144275003729 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1144275003730 classical (c) SDRs; Region: SDR_c; cd05233 1144275003731 NAD(P) binding site [chemical binding]; other site 1144275003732 active site 1144275003733 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1144275003734 active site 1144275003735 PA14 domain; Region: PA14; cl08459 1144275003736 PA14 domain; Region: PA14; cl08459 1144275003737 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1144275003738 putative hydrophobic ligand binding site [chemical binding]; other site 1144275003739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275003740 dimerization interface [polypeptide binding]; other site 1144275003741 putative DNA binding site [nucleotide binding]; other site 1144275003742 putative Zn2+ binding site [ion binding]; other site 1144275003743 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1144275003744 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275003745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275003746 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275003747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275003748 Helix-turn-helix domains; Region: HTH; cl00088 1144275003749 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1144275003750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275003751 Helix-turn-helix domains; Region: HTH; cl00088 1144275003752 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275003753 putative effector binding pocket; other site 1144275003754 putative dimerization interface [polypeptide binding]; other site 1144275003755 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275003756 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275003757 active site 1144275003758 catalytic tetrad [active] 1144275003759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1144275003760 catalytic loop [active] 1144275003761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275003762 iron binding site [ion binding]; other site 1144275003763 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1144275003764 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1144275003765 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275003766 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1144275003767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275003768 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275003769 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003770 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003771 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003772 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003773 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003774 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003775 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1144275003776 active site 1144275003777 catalytic residues [active] 1144275003778 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1144275003779 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275003780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003781 Walker A/P-loop; other site 1144275003782 ATP binding site [chemical binding]; other site 1144275003783 Q-loop/lid; other site 1144275003784 ABC transporter signature motif; other site 1144275003785 Walker B; other site 1144275003786 D-loop; other site 1144275003787 H-loop/switch region; other site 1144275003788 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1144275003789 Uncharacterized conserved protein [Function unknown]; Region: COG3367 1144275003790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275003791 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1144275003792 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275003793 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1144275003794 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003795 Walker A/P-loop; other site 1144275003796 ATP binding site [chemical binding]; other site 1144275003797 Q-loop/lid; other site 1144275003798 ABC transporter signature motif; other site 1144275003799 Walker B; other site 1144275003800 D-loop; other site 1144275003801 H-loop/switch region; other site 1144275003802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003803 Walker A/P-loop; other site 1144275003804 ATP binding site [chemical binding]; other site 1144275003805 Q-loop/lid; other site 1144275003806 ABC transporter signature motif; other site 1144275003807 Walker B; other site 1144275003808 D-loop; other site 1144275003809 H-loop/switch region; other site 1144275003810 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1144275003811 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275003812 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1144275003813 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275003814 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1144275003815 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1144275003816 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1144275003817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275003818 active site 1144275003819 motif I; other site 1144275003820 motif II; other site 1144275003821 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275003822 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1144275003823 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1144275003824 catalytic residue [active] 1144275003825 putative phosphoketolase; Provisional; Region: PRK05261 1144275003826 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1144275003827 TPP-binding site; other site 1144275003828 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1144275003829 XFP C-terminal domain; Region: XFP_C; pfam09363 1144275003830 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275003831 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275003832 putative sugar binding sites [chemical binding]; other site 1144275003833 Q-X-W motif; other site 1144275003834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275003835 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1144275003836 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275003837 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1144275003838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275003839 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1144275003840 Protein of unknown function (DUF808); Region: DUF808; cl01002 1144275003841 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 1144275003842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275003843 dimer interface [polypeptide binding]; other site 1144275003844 phosphorylation site [posttranslational modification] 1144275003845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275003846 ATP binding site [chemical binding]; other site 1144275003847 Mg2+ binding site [ion binding]; other site 1144275003848 G-X-G motif; other site 1144275003849 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275003850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275003851 active site 1144275003852 phosphorylation site [posttranslational modification] 1144275003853 intermolecular recognition site; other site 1144275003854 dimerization interface [polypeptide binding]; other site 1144275003855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275003856 dimer interface [polypeptide binding]; other site 1144275003857 phosphorylation site [posttranslational modification] 1144275003858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275003859 ATP binding site [chemical binding]; other site 1144275003860 Mg2+ binding site [ion binding]; other site 1144275003861 G-X-G motif; other site 1144275003862 DoxX; Region: DoxX; cl00976 1144275003863 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1144275003864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003865 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1144275003866 RNA/DNA hybrid binding site [nucleotide binding]; other site 1144275003867 active site 1144275003868 Protein of unknown function DUF72; Region: DUF72; cl00777 1144275003869 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1144275003870 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275003871 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1144275003872 heme-binding site [chemical binding]; other site 1144275003873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275003874 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275003875 putative DNA binding site [nucleotide binding]; other site 1144275003876 putative Zn2+ binding site [ion binding]; other site 1144275003877 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275003878 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275003879 metal ion-dependent adhesion site (MIDAS); other site 1144275003880 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1144275003881 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 1144275003882 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275003883 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275003884 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275003885 PA14 domain; Region: PA14; cl08459 1144275003886 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275003887 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275003888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275003889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275003890 DNA binding residues [nucleotide binding] 1144275003891 Putative zinc-finger; Region: zf-HC2; cl15806 1144275003892 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1144275003893 DDE superfamily endonuclease; Region: DDE_5; cl02413 1144275003894 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275003895 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275003896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275003897 dimerization interface [polypeptide binding]; other site 1144275003898 putative DNA binding site [nucleotide binding]; other site 1144275003899 putative Zn2+ binding site [ion binding]; other site 1144275003900 Predicted integral membrane protein [Function unknown]; Region: COG5658 1144275003901 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1144275003902 SdpI/YhfL protein family; Region: SdpI; pfam13630 1144275003903 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275003904 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275003905 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275003906 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275003907 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275003908 REJ domain; Region: REJ; pfam02010 1144275003909 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1144275003910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275003911 ATP binding site [chemical binding]; other site 1144275003912 substrate interface [chemical binding]; other site 1144275003913 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1144275003914 Active_site [active] 1144275003915 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1144275003916 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275003917 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275003918 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1144275003919 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 1144275003920 acyl-CoA binding pocket [chemical binding]; other site 1144275003921 CoA binding site [chemical binding]; other site 1144275003922 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1144275003923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275003924 putative active site [active] 1144275003925 putative metal binding site [ion binding]; other site 1144275003926 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1144275003927 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275003928 metal ion-dependent adhesion site (MIDAS); other site 1144275003929 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1144275003930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275003931 Putative zinc-finger; Region: zf-HC2; cl15806 1144275003932 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275003933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275003934 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275003935 CoenzymeA binding site [chemical binding]; other site 1144275003936 subunit interaction site [polypeptide binding]; other site 1144275003937 PHB binding site; other site 1144275003938 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1144275003939 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275003940 Family description; Region: UvrD_C_2; cl15862 1144275003941 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1144275003942 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1144275003943 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1144275003944 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275003945 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1144275003946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1144275003947 Chitin binding domain; Region: Chitin_bind_3; cl03871 1144275003948 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 1144275003949 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003950 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003951 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003952 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003953 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003954 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003955 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003956 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003957 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003958 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003959 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003960 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003961 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003962 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003963 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003964 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003965 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003966 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003967 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003968 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003969 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275003970 TIGR02588 family protein; Region: TIGR02588 1144275003971 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 1144275003972 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1144275003973 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1144275003974 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1144275003975 putative active site [active] 1144275003976 putative substrate binding site [chemical binding]; other site 1144275003977 putative cosubstrate binding site; other site 1144275003978 catalytic site [active] 1144275003979 TPR repeat; Region: TPR_11; pfam13414 1144275003980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275003981 binding surface 1144275003982 TPR motif; other site 1144275003983 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275003984 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275003985 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275003986 DNA binding residues [nucleotide binding] 1144275003987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275003988 putative substrate translocation pore; other site 1144275003989 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1144275003990 active site 1144275003991 PQQ-like domain; Region: PQQ_2; pfam13360 1144275003992 Trp docking motif [polypeptide binding]; other site 1144275003993 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1144275003994 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1144275003995 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1144275003996 active site 1144275003997 purine riboside binding site [chemical binding]; other site 1144275003998 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1144275003999 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1144275004000 ligand binding site; other site 1144275004001 oligomer interface; other site 1144275004002 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1144275004003 dimer interface [polypeptide binding]; other site 1144275004004 N-terminal domain interface [polypeptide binding]; other site 1144275004005 sulfate 1 binding site; other site 1144275004006 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275004007 phosphopeptide binding site; other site 1144275004008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275004009 metal binding site [ion binding]; metal-binding site 1144275004010 active site 1144275004011 I-site; other site 1144275004012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004013 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1144275004014 NAD(P) binding site [chemical binding]; other site 1144275004015 active site 1144275004016 fatty acyl-CoA reductase; Region: PLN02996 1144275004017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004018 active site 1144275004019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004020 active site 1144275004021 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 1144275004022 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275004023 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275004024 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275004025 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275004026 putative acyl-acceptor binding pocket; other site 1144275004027 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1144275004028 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1144275004029 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275004030 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1144275004031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004032 NAD(P) binding site [chemical binding]; other site 1144275004033 active site 1144275004034 SWIB/MDM2 domain; Region: SWIB; cl02489 1144275004035 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1144275004036 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1144275004037 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1144275004038 active site 1144275004039 catalytic site [active] 1144275004040 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1144275004041 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1144275004042 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1144275004043 active site 1144275004044 catalytic site [active] 1144275004045 Integral membrane protein TerC family; Region: TerC; cl10468 1144275004046 Protein of unknown function (DUF525); Region: DUF525; cl01119 1144275004047 ferrochelatase; Reviewed; Region: hemH; PRK00035 1144275004048 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1144275004049 C-terminal domain interface [polypeptide binding]; other site 1144275004050 active site 1144275004051 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1144275004052 active site 1144275004053 N-terminal domain interface [polypeptide binding]; other site 1144275004054 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1144275004055 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1144275004056 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1144275004057 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1144275004058 putative hydrophobic ligand binding site [chemical binding]; other site 1144275004059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004060 NAD(P) binding site [chemical binding]; other site 1144275004061 TIGR01777 family protein; Region: yfcH 1144275004062 active site 1144275004063 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1144275004064 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275004065 Walker A/P-loop; other site 1144275004066 ATP binding site [chemical binding]; other site 1144275004067 Q-loop/lid; other site 1144275004068 ABC transporter signature motif; other site 1144275004069 Walker B; other site 1144275004070 D-loop; other site 1144275004071 H-loop/switch region; other site 1144275004072 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275004073 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1144275004074 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1144275004075 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1144275004076 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1144275004077 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275004078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275004079 active site 1144275004080 phosphorylation site [posttranslational modification] 1144275004081 intermolecular recognition site; other site 1144275004082 dimerization interface [polypeptide binding]; other site 1144275004083 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1144275004084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275004085 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275004086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275004087 dimer interface [polypeptide binding]; other site 1144275004088 phosphorylation site [posttranslational modification] 1144275004089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275004090 ATP binding site [chemical binding]; other site 1144275004091 Mg2+ binding site [ion binding]; other site 1144275004092 G-X-G motif; other site 1144275004093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004094 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1144275004095 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1144275004096 [2Fe-2S] cluster binding site [ion binding]; other site 1144275004097 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1144275004098 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1144275004099 endonuclease III; Region: ENDO3c; smart00478 1144275004100 minor groove reading motif; other site 1144275004101 helix-hairpin-helix signature motif; other site 1144275004102 substrate binding pocket [chemical binding]; other site 1144275004103 active site 1144275004104 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1144275004105 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275004106 NAD binding site [chemical binding]; other site 1144275004107 catalytic Zn binding site [ion binding]; other site 1144275004108 structural Zn binding site [ion binding]; other site 1144275004109 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1144275004110 muropeptide transporter; Validated; Region: ampG; PRK11010 1144275004111 AmpG-like permease; Region: 2A0125; TIGR00901 1144275004112 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1144275004113 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1144275004114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275004115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275004116 homodimer interface [polypeptide binding]; other site 1144275004117 catalytic residue [active] 1144275004118 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1144275004119 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1144275004120 dimerization interface [polypeptide binding]; other site 1144275004121 DPS ferroxidase diiron center [ion binding]; other site 1144275004122 ion pore; other site 1144275004123 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1144275004124 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1144275004125 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1144275004126 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1144275004127 dimer interface [polypeptide binding]; other site 1144275004128 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1144275004129 catalytic triad [active] 1144275004130 peroxidatic and resolving cysteines [active] 1144275004131 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1144275004132 GAF domain; Region: GAF; cl15785 1144275004133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275004134 Walker A motif; other site 1144275004135 ATP binding site [chemical binding]; other site 1144275004136 Walker B motif; other site 1144275004137 arginine finger; other site 1144275004138 ribonuclease E; Reviewed; Region: rne; PRK10811 1144275004139 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1144275004140 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 1144275004141 putative active site [active] 1144275004142 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1144275004143 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1144275004144 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1144275004145 catalytic core [active] 1144275004146 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1144275004147 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1144275004148 putative active site [active] 1144275004149 putative substrate binding site [chemical binding]; other site 1144275004150 ATP binding site [chemical binding]; other site 1144275004151 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275004152 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275004153 active site 1144275004154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275004155 Helix-turn-helix domains; Region: HTH; cl00088 1144275004156 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1144275004157 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275004158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275004159 catalytic residue [active] 1144275004160 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1144275004161 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1144275004162 dimer interface [polypeptide binding]; other site 1144275004163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275004164 catalytic residue [active] 1144275004165 serine O-acetyltransferase; Region: cysE; TIGR01172 1144275004166 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1144275004167 trimer interface [polypeptide binding]; other site 1144275004168 active site 1144275004169 substrate binding site [chemical binding]; other site 1144275004170 CoA binding site [chemical binding]; other site 1144275004171 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1144275004172 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1144275004173 DNA binding site [nucleotide binding] 1144275004174 catalytic residue [active] 1144275004175 H2TH interface [polypeptide binding]; other site 1144275004176 putative catalytic residues [active] 1144275004177 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1144275004178 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1144275004179 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004181 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275004182 binding surface 1144275004183 TPR motif; other site 1144275004184 AMP-binding domain protein; Validated; Region: PRK08315 1144275004185 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275004186 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275004187 TfoX N-terminal domain; Region: TfoX_N; cl01167 1144275004188 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1144275004189 motif 1; other site 1144275004190 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275004191 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1144275004192 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1144275004194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275004195 DNA-binding site [nucleotide binding]; DNA binding site 1144275004196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275004197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275004198 homodimer interface [polypeptide binding]; other site 1144275004199 catalytic residue [active] 1144275004200 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275004201 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275004202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275004203 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1144275004204 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275004205 active site 1144275004206 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275004207 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275004208 putative catalytic site [active] 1144275004209 putative metal binding site [ion binding]; other site 1144275004210 putative phosphate binding site [ion binding]; other site 1144275004211 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1144275004212 Lamin Tail Domain; Region: LTD; pfam00932 1144275004213 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275004214 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1144275004215 putative C-terminal domain interface [polypeptide binding]; other site 1144275004216 putative GSH binding site (G-site) [chemical binding]; other site 1144275004217 putative dimer interface [polypeptide binding]; other site 1144275004218 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1144275004219 putative N-terminal domain interface [polypeptide binding]; other site 1144275004220 putative dimer interface [polypeptide binding]; other site 1144275004221 putative substrate binding pocket (H-site) [chemical binding]; other site 1144275004222 potential frameshift: common BLAST hit: gi|338533439|ref|YP_004666773.1| S37 family peptidase 1144275004223 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 1144275004224 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 1144275004225 Peptidase family M49; Region: Peptidase_M49; pfam03571 1144275004226 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1144275004227 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1144275004228 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1144275004229 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1144275004230 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1144275004231 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1144275004232 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1144275004233 active site 1144275004234 uracil binding [chemical binding]; other site 1144275004235 Protein kinase domain; Region: Pkinase; pfam00069 1144275004236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275004237 active site 1144275004238 ATP binding site [chemical binding]; other site 1144275004239 substrate binding site [chemical binding]; other site 1144275004240 activation loop (A-loop); other site 1144275004241 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 1144275004242 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275004243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004244 TPR motif; other site 1144275004245 binding surface 1144275004246 Protein kinase domain; Region: Pkinase; pfam00069 1144275004247 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275004248 active site 1144275004249 ATP binding site [chemical binding]; other site 1144275004250 substrate binding site [chemical binding]; other site 1144275004251 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275004252 substrate binding site [chemical binding]; other site 1144275004253 activation loop (A-loop); other site 1144275004254 activation loop (A-loop); other site 1144275004255 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275004256 Protein kinase domain; Region: Pkinase; pfam00069 1144275004257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275004258 active site 1144275004259 ATP binding site [chemical binding]; other site 1144275004260 substrate binding site [chemical binding]; other site 1144275004261 activation loop (A-loop); other site 1144275004262 TPR repeat; Region: TPR_11; pfam13414 1144275004263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004264 binding surface 1144275004265 TPR motif; other site 1144275004266 Protein kinase domain; Region: Pkinase; pfam00069 1144275004267 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275004268 active site 1144275004269 ATP binding site [chemical binding]; other site 1144275004270 substrate binding site [chemical binding]; other site 1144275004271 activation loop (A-loop); other site 1144275004272 transport protein TonB; Provisional; Region: PRK10819 1144275004273 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275004274 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275004275 active site 1144275004276 ATP binding site [chemical binding]; other site 1144275004277 substrate binding site [chemical binding]; other site 1144275004278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275004279 substrate binding site [chemical binding]; other site 1144275004280 activation loop (A-loop); other site 1144275004281 activation loop (A-loop); other site 1144275004282 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275004283 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1144275004284 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275004285 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1144275004286 NMT1-like family; Region: NMT1_2; cl15260 1144275004287 tellurium resistance terB-like protein; Region: terB_like; cd07177 1144275004288 metal binding site [ion binding]; metal-binding site 1144275004289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275004290 DNA binding residues [nucleotide binding] 1144275004291 dimerization interface [polypeptide binding]; other site 1144275004292 GAF domain; Region: GAF_2; pfam13185 1144275004293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275004294 DNA binding residues [nucleotide binding] 1144275004295 dimerization interface [polypeptide binding]; other site 1144275004296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275004297 DNA binding residues [nucleotide binding] 1144275004298 dimerization interface [polypeptide binding]; other site 1144275004299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004300 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275004301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004302 TIGR01777 family protein; Region: yfcH 1144275004303 NAD(P) binding site [chemical binding]; other site 1144275004304 active site 1144275004305 Endonuclease I; Region: Endonuclease_1; cl01003 1144275004306 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1144275004307 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1144275004308 OpgC protein; Region: OpgC_C; cl00792 1144275004309 acyl-CoA synthetase; Validated; Region: PRK05850 1144275004310 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275004311 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275004312 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1144275004313 amidohydrolase; Region: amidohydrolases; TIGR01891 1144275004314 metal binding site [ion binding]; metal-binding site 1144275004315 putative dimer interface [polypeptide binding]; other site 1144275004316 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1144275004317 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 1144275004318 active site 1144275004319 metal binding site [ion binding]; metal-binding site 1144275004320 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1144275004321 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275004322 N-terminal plug; other site 1144275004323 ligand-binding site [chemical binding]; other site 1144275004324 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 1144275004325 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1144275004326 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1144275004327 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1144275004328 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1144275004329 intersubunit interface [polypeptide binding]; other site 1144275004330 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1144275004331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1144275004332 putative PBP binding regions; other site 1144275004333 ABC-ATPase subunit interface; other site 1144275004334 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1144275004335 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1144275004336 Walker A/P-loop; other site 1144275004337 ATP binding site [chemical binding]; other site 1144275004338 Q-loop/lid; other site 1144275004339 ABC transporter signature motif; other site 1144275004340 Walker B; other site 1144275004341 D-loop; other site 1144275004342 H-loop/switch region; other site 1144275004343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275004344 Helix-turn-helix domains; Region: HTH; cl00088 1144275004345 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275004346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004347 NAD(P) binding site [chemical binding]; other site 1144275004348 active site 1144275004349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275004350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275004351 DNA-binding site [nucleotide binding]; DNA binding site 1144275004352 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275004354 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275004355 MFS transport protein AraJ; Provisional; Region: PRK10091 1144275004356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275004357 putative substrate translocation pore; other site 1144275004358 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 1144275004359 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004360 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 1144275004361 substrate-cofactor binding pocket; other site 1144275004362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275004363 catalytic residue [active] 1144275004364 PAS fold; Region: PAS_4; pfam08448 1144275004365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275004366 PAS fold; Region: PAS_4; pfam08448 1144275004367 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275004368 GAF domain; Region: GAF; cl15785 1144275004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275004370 dimer interface [polypeptide binding]; other site 1144275004371 phosphorylation site [posttranslational modification] 1144275004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275004373 ATP binding site [chemical binding]; other site 1144275004374 Mg2+ binding site [ion binding]; other site 1144275004375 G-X-G motif; other site 1144275004376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275004377 AAA-like domain; Region: AAA_10; pfam12846 1144275004378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275004379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275004380 putative substrate translocation pore; other site 1144275004381 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275004382 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1144275004383 putative NAD(P) binding site [chemical binding]; other site 1144275004384 active site 1144275004385 putative substrate binding site [chemical binding]; other site 1144275004386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1144275004387 putative acyl-acceptor binding pocket; other site 1144275004388 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1144275004389 putative heme binding pocket [chemical binding]; other site 1144275004390 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1144275004391 putative hydrophobic ligand binding site [chemical binding]; other site 1144275004392 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 1144275004393 Helix-turn-helix domains; Region: HTH; cl00088 1144275004394 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1144275004395 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275004396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275004397 DNA-binding site [nucleotide binding]; DNA binding site 1144275004398 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1144275004399 active site 1144275004400 catalytic residues [active] 1144275004401 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1144275004402 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275004403 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 1144275004404 putative NAD(P) binding site [chemical binding]; other site 1144275004405 catalytic Zn binding site [ion binding]; other site 1144275004406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1144275004407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1144275004409 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275004410 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275004411 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1144275004412 Walker A/P-loop; other site 1144275004413 ATP binding site [chemical binding]; other site 1144275004414 Q-loop/lid; other site 1144275004415 ABC transporter signature motif; other site 1144275004416 Walker B; other site 1144275004417 D-loop; other site 1144275004418 H-loop/switch region; other site 1144275004419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004420 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1144275004421 NAD(P) binding site [chemical binding]; other site 1144275004422 active site 1144275004423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004424 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1144275004425 NAD(P) binding site [chemical binding]; other site 1144275004426 active site 1144275004427 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275004428 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275004429 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275004430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1144275004431 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275004432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1144275004433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1144275004434 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275004435 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1144275004436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004437 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1144275004438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004439 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 1144275004440 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1144275004441 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1144275004442 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1144275004443 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 1144275004444 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1144275004445 Family description; Region: VCBS; pfam13517 1144275004446 Family description; Region: VCBS; pfam13517 1144275004447 Family description; Region: VCBS; pfam13517 1144275004448 Family description; Region: VCBS; pfam13517 1144275004449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275004450 S-adenosylmethionine binding site [chemical binding]; other site 1144275004451 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1144275004452 AAA domain; Region: AAA_23; pfam13476 1144275004453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275004454 Walker B; other site 1144275004455 D-loop; other site 1144275004456 H-loop/switch region; other site 1144275004457 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275004458 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1144275004459 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275004460 AAA domain; Region: AAA_33; pfam13671 1144275004461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275004462 active site 1144275004463 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275004464 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1144275004465 active site 1144275004466 catalytic residues [active] 1144275004467 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1144275004468 conserved cys residue [active] 1144275004469 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 1144275004470 PKC phosphorylation site [posttranslational modification]; other site 1144275004471 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1144275004472 active site 1144275004473 catalytic residues [active] 1144275004474 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 1144275004475 MgtC family; Region: MgtC; pfam02308 1144275004476 Predicted membrane protein [Function unknown]; Region: COG3174 1144275004477 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1144275004478 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1144275004479 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1144275004480 dimer interface [polypeptide binding]; other site 1144275004481 active site 1144275004482 OsmC-like protein; Region: OsmC; cl00767 1144275004483 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1144275004484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1144275004485 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275004486 phosphopeptide binding site; other site 1144275004487 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275004488 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275004489 active site 1144275004490 ATP binding site [chemical binding]; other site 1144275004491 substrate binding site [chemical binding]; other site 1144275004492 activation loop (A-loop); other site 1144275004493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275004494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275004495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275004496 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275004497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275004498 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275004499 phosphopeptide binding site; other site 1144275004500 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275004501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275004502 Walker A motif; other site 1144275004503 ATP binding site [chemical binding]; other site 1144275004504 Walker B motif; other site 1144275004505 arginine finger; other site 1144275004506 Helix-turn-helix domains; Region: HTH; cl00088 1144275004507 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1144275004508 putative active site [active] 1144275004509 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1144275004510 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 1144275004511 JmjC domain, hydroxylase; Region: JmjC; cl15814 1144275004512 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1144275004513 apolar tunnel; other site 1144275004514 heme binding site [chemical binding]; other site 1144275004515 dimerization interface [polypeptide binding]; other site 1144275004516 hypothetical protein; Provisional; Region: PRK05713 1144275004517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1144275004518 catalytic loop [active] 1144275004519 iron binding site [ion binding]; other site 1144275004520 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1144275004521 FAD binding pocket [chemical binding]; other site 1144275004522 FAD binding motif [chemical binding]; other site 1144275004523 phosphate binding motif [ion binding]; other site 1144275004524 beta-alpha-beta structure motif; other site 1144275004525 NAD binding pocket [chemical binding]; other site 1144275004526 Helix-turn-helix domains; Region: HTH; cl00088 1144275004527 Rrf2 family protein; Region: rrf2_super; TIGR00738 1144275004528 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1144275004529 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275004530 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 1144275004531 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1144275004532 Interdomain contacts; other site 1144275004533 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 1144275004534 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275004535 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 1144275004536 starch-binding site 2 [chemical binding]; other site 1144275004537 starch-binding site 1 [chemical binding]; other site 1144275004538 methionine S-methyltransferase; Region: PLN02672 1144275004539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275004540 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275004541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275004542 catalytic residue [active] 1144275004543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275004544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275004545 homodimer interface [polypeptide binding]; other site 1144275004546 catalytic residue [active] 1144275004547 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 1144275004548 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1144275004549 putative hydrophobic ligand binding site [chemical binding]; other site 1144275004550 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1144275004551 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275004552 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1144275004553 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275004554 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275004555 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1144275004556 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1144275004557 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1144275004558 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275004559 structural tetrad; other site 1144275004560 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275004561 structural tetrad; other site 1144275004562 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1144275004563 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275004564 putative NAD(P) binding site [chemical binding]; other site 1144275004565 Annexin; Region: Annexin; cl02574 1144275004566 Annexin; Region: Annexin; cl02574 1144275004567 Annexin; Region: Annexin; cl02574 1144275004568 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275004569 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275004570 catalytic residue [active] 1144275004571 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275004572 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275004573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1144275004574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275004575 dimer interface [polypeptide binding]; other site 1144275004576 phosphorylation site [posttranslational modification] 1144275004577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275004578 ATP binding site [chemical binding]; other site 1144275004579 Mg2+ binding site [ion binding]; other site 1144275004580 G-X-G motif; other site 1144275004581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275004582 putative active site [active] 1144275004583 LysE type translocator; Region: LysE; cl00565 1144275004584 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1144275004585 Helix-turn-helix domains; Region: HTH; cl00088 1144275004586 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1144275004587 dimerization interface [polypeptide binding]; other site 1144275004588 substrate binding pocket [chemical binding]; other site 1144275004589 Predicted peptidase [General function prediction only]; Region: COG4099 1144275004590 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275004592 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 1144275004593 PLD-like domain; Region: PLDc_2; pfam13091 1144275004594 putative homodimer interface [polypeptide binding]; other site 1144275004595 putative active site [active] 1144275004596 catalytic site [active] 1144275004597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275004598 ATP binding site [chemical binding]; other site 1144275004599 putative Mg++ binding site [ion binding]; other site 1144275004600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275004601 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1144275004602 classical (c) SDRs; Region: SDR_c; cd05233 1144275004603 NAD(P) binding site [chemical binding]; other site 1144275004604 active site 1144275004605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275004606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275004607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275004608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1144275004609 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1144275004610 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1144275004611 active site 1144275004612 Zn binding site [ion binding]; other site 1144275004613 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1144275004614 Helix-turn-helix domains; Region: HTH; cl00088 1144275004615 AsnC family; Region: AsnC_trans_reg; pfam01037 1144275004616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004617 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1144275004618 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1144275004619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275004620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275004621 MMPL family; Region: MMPL; pfam03176 1144275004622 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1144275004623 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1144275004624 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275004625 active site 1144275004626 squalene epoxidase; Provisional; Region: PTZ00367 1144275004627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004628 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1144275004629 substrate binding pocket [chemical binding]; other site 1144275004630 substrate-Mg2+ binding site; other site 1144275004631 aspartate-rich region 1; other site 1144275004632 aspartate-rich region 2; other site 1144275004633 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1144275004634 2,3-oxidosqualene cyclase; Region: osq_cycl; TIGR03463 1144275004635 Active site cavity [active] 1144275004636 catalytic acid [active] 1144275004637 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 1144275004638 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1144275004639 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275004640 Helix-turn-helix domains; Region: HTH; cl00088 1144275004641 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1144275004642 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1144275004643 active site 1144275004644 metal binding site [ion binding]; metal-binding site 1144275004645 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275004646 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1144275004647 Aspartase; Region: Aspartase; cd01357 1144275004648 active sites [active] 1144275004649 tetramer interface [polypeptide binding]; other site 1144275004650 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1144275004651 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1144275004652 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1144275004653 interface (dimer of trimers) [polypeptide binding]; other site 1144275004654 Substrate-binding/catalytic site; other site 1144275004655 Zn-binding sites [ion binding]; other site 1144275004656 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1144275004657 active site 1144275004658 homotetramer interface [polypeptide binding]; other site 1144275004659 homodimer interface [polypeptide binding]; other site 1144275004660 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1144275004661 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1144275004662 Protein of unknown function, DUF481; Region: DUF481; cl01213 1144275004663 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1144275004664 active site 1144275004665 catalytic triad [active] 1144275004666 oxyanion hole [active] 1144275004667 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004668 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004669 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004670 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004671 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004672 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004673 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004674 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004675 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004676 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004677 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004678 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004679 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004680 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004681 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004682 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004683 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004684 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004685 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1144275004686 Helix-turn-helix domains; Region: HTH; cl00088 1144275004687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275004688 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275004689 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275004690 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1144275004691 Protein export membrane protein; Region: SecD_SecF; cl14618 1144275004692 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275004693 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275004694 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275004695 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1144275004696 Helix-turn-helix domains; Region: HTH; cl00088 1144275004697 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275004698 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275004699 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275004700 metal ion-dependent adhesion site (MIDAS); other site 1144275004701 EF-hand domain pair; Region: EF_hand_5; pfam13499 1144275004702 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275004703 metal ion-dependent adhesion site (MIDAS); other site 1144275004704 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004705 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004706 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004707 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004708 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004709 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004710 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004711 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004712 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004713 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004714 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004715 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275004716 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004717 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004718 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275004719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275004720 Histidine kinase; Region: His_kinase; pfam06580 1144275004721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275004722 ATP binding site [chemical binding]; other site 1144275004723 Mg2+ binding site [ion binding]; other site 1144275004724 G-X-G motif; other site 1144275004725 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1144275004726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275004727 active site 1144275004728 phosphorylation site [posttranslational modification] 1144275004729 intermolecular recognition site; other site 1144275004730 dimerization interface [polypeptide binding]; other site 1144275004731 LytTr DNA-binding domain; Region: LytTR; cl04498 1144275004732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275004733 LysR family transcriptional regulator; Provisional; Region: PRK14997 1144275004734 Helix-turn-helix domains; Region: HTH; cl00088 1144275004735 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275004736 putative effector binding pocket; other site 1144275004737 dimerization interface [polypeptide binding]; other site 1144275004738 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275004739 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1144275004740 putative C-terminal domain interface [polypeptide binding]; other site 1144275004741 putative GSH binding site (G-site) [chemical binding]; other site 1144275004742 putative dimer interface [polypeptide binding]; other site 1144275004743 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275004744 N-terminal domain interface [polypeptide binding]; other site 1144275004745 dimer interface [polypeptide binding]; other site 1144275004746 substrate binding pocket (H-site) [chemical binding]; other site 1144275004747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275004748 dimerization interface [polypeptide binding]; other site 1144275004749 putative DNA binding site [nucleotide binding]; other site 1144275004750 putative Zn2+ binding site [ion binding]; other site 1144275004751 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1144275004752 putative hydrophobic ligand binding site [chemical binding]; other site 1144275004753 DoxX; Region: DoxX; cl00976 1144275004754 Protein of unknown function (DUF419); Region: DUF419; cl15265 1144275004755 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1144275004756 NlpC/P60 family; Region: NLPC_P60; cl11438 1144275004757 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275004758 Peptidase family M48; Region: Peptidase_M48; cl12018 1144275004759 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1144275004760 NeuB family; Region: NeuB; cl00496 1144275004761 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1144275004762 Deoxyhypusine synthase; Region: DS; cl00826 1144275004763 Beta-propeller repeat; Region: SBBP; pfam06739 1144275004764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004765 NAD(P) binding site [chemical binding]; other site 1144275004766 active site 1144275004767 Helix-turn-helix domains; Region: HTH; cl00088 1144275004768 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275004769 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1144275004770 Immunoglobulin I-set domain; Region: I-set; pfam07679 1144275004771 Immunoglobulin domain; Region: Ig; cl11960 1144275004772 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275004773 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1144275004774 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1144275004775 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275004776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275004777 S-adenosylmethionine binding site [chemical binding]; other site 1144275004778 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1144275004779 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1144275004780 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1144275004781 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1144275004782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275004783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275004784 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1144275004785 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275004786 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1144275004787 active site 1144275004788 catalytic tetrad [active] 1144275004789 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275004790 Helix-turn-helix domains; Region: HTH; cl00088 1144275004791 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275004792 putative effector binding pocket; other site 1144275004793 putative dimerization interface [polypeptide binding]; other site 1144275004794 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 1144275004795 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1144275004796 nucleoside/Zn binding site; other site 1144275004797 dimer interface [polypeptide binding]; other site 1144275004798 catalytic motif [active] 1144275004799 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275004800 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275004801 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1144275004802 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1144275004803 Cupin domain; Region: Cupin_2; cl09118 1144275004804 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1144275004805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275004806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275004807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275004808 active site 1144275004809 metal binding site [ion binding]; metal-binding site 1144275004810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275004811 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1144275004812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275004813 dimer interface [polypeptide binding]; other site 1144275004814 phosphorylation site [posttranslational modification] 1144275004815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275004816 ATP binding site [chemical binding]; other site 1144275004817 Mg2+ binding site [ion binding]; other site 1144275004818 G-X-G motif; other site 1144275004819 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1144275004820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275004821 active site 1144275004822 phosphorylation site [posttranslational modification] 1144275004823 intermolecular recognition site; other site 1144275004824 dimerization interface [polypeptide binding]; other site 1144275004825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275004826 DNA binding residues [nucleotide binding] 1144275004827 dimerization interface [polypeptide binding]; other site 1144275004828 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1144275004829 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 1144275004830 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 1144275004831 Helix-turn-helix domains; Region: HTH; cl00088 1144275004832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275004833 Coenzyme A binding pocket [chemical binding]; other site 1144275004834 putative acetyltransferase; Provisional; Region: PRK03624 1144275004835 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1144275004836 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1144275004837 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1144275004838 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275004839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275004840 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275004841 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1144275004842 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 1144275004843 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1144275004844 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1144275004845 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1144275004846 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1144275004847 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1144275004848 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 1144275004849 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1144275004850 Na binding site [ion binding]; other site 1144275004851 hypothetical protein; Provisional; Region: PRK06834 1144275004852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004853 Helix-turn-helix domains; Region: HTH; cl00088 1144275004854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004855 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1144275004856 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1144275004857 conserved cys residue [active] 1144275004858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275004859 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1144275004860 dimer interface [polypeptide binding]; other site 1144275004861 FMN binding site [chemical binding]; other site 1144275004862 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1144275004863 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1144275004864 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275004865 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275004866 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1144275004867 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1144275004868 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275004869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275004870 Walker A motif; other site 1144275004871 ATP binding site [chemical binding]; other site 1144275004872 Walker B motif; other site 1144275004873 arginine finger; other site 1144275004874 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1144275004875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1144275004876 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1144275004877 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1144275004878 Baseplate J-like protein; Region: Baseplate_J; cl01294 1144275004879 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1144275004880 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1144275004881 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1144275004882 active site 1144275004883 metal binding site [ion binding]; metal-binding site 1144275004884 interdomain interaction site; other site 1144275004885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275004886 Helix-turn-helix domains; Region: HTH; cl00088 1144275004887 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275004888 putative effector binding pocket; other site 1144275004889 putative dimerization interface [polypeptide binding]; other site 1144275004890 short chain dehydrogenase; Provisional; Region: PRK07060 1144275004891 classical (c) SDRs; Region: SDR_c; cd05233 1144275004892 NAD(P) binding site [chemical binding]; other site 1144275004893 active site 1144275004894 DDE superfamily endonuclease; Region: DDE_5; cl02413 1144275004895 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1144275004896 Integrase core domain; Region: rve; cl01316 1144275004897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275004898 Helix-turn-helix domains; Region: HTH; cl00088 1144275004899 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275004900 putative effector binding pocket; other site 1144275004901 putative dimerization interface [polypeptide binding]; other site 1144275004902 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275004903 short chain dehydrogenase; Provisional; Region: PRK06523 1144275004904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275004905 NAD(P) binding site [chemical binding]; other site 1144275004906 active site 1144275004907 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 1144275004908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275004909 dimer interface [polypeptide binding]; other site 1144275004910 phosphorylation site [posttranslational modification] 1144275004911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275004912 ATP binding site [chemical binding]; other site 1144275004913 Mg2+ binding site [ion binding]; other site 1144275004914 G-X-G motif; other site 1144275004915 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1144275004916 AsmA-like C-terminal region; Region: AsmA_2; cl15864 1144275004917 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1144275004918 DDE superfamily endonuclease; Region: DDE_5; cl02413 1144275004919 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275004920 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275004921 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1144275004922 Helix-turn-helix domains; Region: HTH; cl00088 1144275004923 Integrase core domain; Region: rve; cl01316 1144275004924 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275004925 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1144275004926 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1144275004927 putative active site [active] 1144275004928 putative metal binding site [ion binding]; other site 1144275004929 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275004930 Helix-turn-helix domains; Region: HTH; cl00088 1144275004931 putative transposase OrfB; Reviewed; Region: PHA02517 1144275004932 HTH-like domain; Region: HTH_21; pfam13276 1144275004933 Integrase core domain; Region: rve; cl01316 1144275004934 Integrase core domain; Region: rve_3; cl15866 1144275004935 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1144275004936 dimer interface [polypeptide binding]; other site 1144275004937 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275004938 structural tetrad; other site 1144275004939 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275004940 structural tetrad; other site 1144275004941 Integrase core domain; Region: rve; cl01316 1144275004942 HNH endonuclease; Region: HNH_5; pfam14279 1144275004943 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1144275004944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275004945 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1144275004946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275004947 S-adenosylmethionine binding site [chemical binding]; other site 1144275004948 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1144275004949 dimer interface [polypeptide binding]; other site 1144275004950 catalytic triad [active] 1144275004951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275004952 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 1144275004953 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1144275004954 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1144275004955 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 1144275004956 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1144275004957 catalytic residues [active] 1144275004958 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1144275004959 active site 1144275004960 dimerization interface [polypeptide binding]; other site 1144275004961 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1144275004962 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1144275004963 SLBB domain; Region: SLBB; pfam10531 1144275004964 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275004965 ligand binding site [chemical binding]; other site 1144275004966 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275004967 TPR repeat; Region: TPR_11; pfam13414 1144275004968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275004969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004970 TPR motif; other site 1144275004971 binding surface 1144275004972 TPR repeat; Region: TPR_11; pfam13414 1144275004973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004974 binding surface 1144275004975 TPR motif; other site 1144275004976 TPR repeat; Region: TPR_11; pfam13414 1144275004977 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275004978 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1144275004979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004980 binding surface 1144275004981 TPR motif; other site 1144275004982 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275004983 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275004984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275004985 binding surface 1144275004986 TPR motif; other site 1144275004987 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275004988 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1144275004989 G1 box; other site 1144275004990 GTP/Mg2+ binding site [chemical binding]; other site 1144275004991 G2 box; other site 1144275004992 Switch I region; other site 1144275004993 G3 box; other site 1144275004994 Switch II region; other site 1144275004995 G4 box; other site 1144275004996 G5 box; other site 1144275004997 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1144275004998 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275004999 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005000 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005001 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275005002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275005003 active site 1144275005004 ATP binding site [chemical binding]; other site 1144275005005 substrate binding site [chemical binding]; other site 1144275005006 activation loop (A-loop); other site 1144275005007 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275005008 recombination protein RecR; Reviewed; Region: recR; PRK00076 1144275005009 RecR protein; Region: RecR; pfam02132 1144275005010 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1144275005011 putative active site [active] 1144275005012 putative metal-binding site [ion binding]; other site 1144275005013 tetramer interface [polypeptide binding]; other site 1144275005014 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1144275005015 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 1144275005016 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1144275005017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005018 Walker A motif; other site 1144275005019 ATP binding site [chemical binding]; other site 1144275005020 Walker B motif; other site 1144275005021 arginine finger; other site 1144275005022 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1144275005023 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1144275005024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005025 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275005026 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275005027 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1144275005028 nucleoside/Zn binding site; other site 1144275005029 dimer interface [polypeptide binding]; other site 1144275005030 catalytic motif [active] 1144275005031 seryl-tRNA synthetase; Provisional; Region: PRK05431 1144275005032 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1144275005033 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1144275005034 dimer interface [polypeptide binding]; other site 1144275005035 active site 1144275005036 motif 1; other site 1144275005037 motif 2; other site 1144275005038 motif 3; other site 1144275005039 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275005040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005041 binding surface 1144275005042 TPR motif; other site 1144275005043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005044 binding surface 1144275005045 TPR motif; other site 1144275005046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005047 binding surface 1144275005048 TPR motif; other site 1144275005049 TPR repeat; Region: TPR_11; pfam13414 1144275005050 TPR repeat; Region: TPR_11; pfam13414 1144275005051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005052 TPR motif; other site 1144275005053 binding surface 1144275005054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005055 TPR repeat; Region: TPR_11; pfam13414 1144275005056 binding surface 1144275005057 TPR motif; other site 1144275005058 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1144275005059 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1144275005060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005061 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1144275005062 Ligand binding site; other site 1144275005063 Putative Catalytic site; other site 1144275005064 DXD motif; other site 1144275005065 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1144275005066 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 1144275005067 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1144275005068 putative acyl-acceptor binding pocket; other site 1144275005069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275005070 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1144275005071 putative NAD(P) binding site [chemical binding]; other site 1144275005072 active site 1144275005073 putative substrate binding site [chemical binding]; other site 1144275005074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005075 binding surface 1144275005076 TPR motif; other site 1144275005077 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275005078 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275005079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005080 TPR motif; other site 1144275005081 binding surface 1144275005082 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275005083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005084 TPR motif; other site 1144275005085 binding surface 1144275005086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005087 binding surface 1144275005088 TPR motif; other site 1144275005089 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1144275005090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275005091 ATP binding site [chemical binding]; other site 1144275005092 putative Mg++ binding site [ion binding]; other site 1144275005093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275005094 nucleotide binding region [chemical binding]; other site 1144275005095 ATP-binding site [chemical binding]; other site 1144275005096 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1144275005097 HRDC domain; Region: HRDC; cl02578 1144275005098 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1144275005099 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1144275005100 MPN+ (JAMM) motif; other site 1144275005101 Zinc-binding site [ion binding]; other site 1144275005102 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275005103 ligand binding site [chemical binding]; other site 1144275005104 flexible hinge region; other site 1144275005105 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1144275005106 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275005107 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1144275005108 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275005109 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275005110 catalytic residue [active] 1144275005111 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1144275005112 trimer interface [polypeptide binding]; other site 1144275005113 dimer interface [polypeptide binding]; other site 1144275005114 putative active site [active] 1144275005115 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1144275005116 dimer interface [polypeptide binding]; other site 1144275005117 ADP-ribose binding site [chemical binding]; other site 1144275005118 active site 1144275005119 nudix motif; other site 1144275005120 metal binding site [ion binding]; metal-binding site 1144275005121 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1144275005122 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1144275005123 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1144275005124 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1144275005125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005126 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1144275005127 active site 1144275005128 catalytic residues [active] 1144275005129 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1144275005130 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275005131 active site 1144275005132 nucleophile elbow; other site 1144275005133 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275005134 dimerization interface [polypeptide binding]; other site 1144275005135 putative DNA binding site [nucleotide binding]; other site 1144275005136 putative Zn2+ binding site [ion binding]; other site 1144275005137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275005138 S-adenosylmethionine binding site [chemical binding]; other site 1144275005139 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1144275005140 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1144275005141 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1144275005142 substrate binding pocket [chemical binding]; other site 1144275005143 dimer interface [polypeptide binding]; other site 1144275005144 inhibitor binding site; inhibition site 1144275005145 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1144275005146 B12 binding site [chemical binding]; other site 1144275005147 cobalt ligand [ion binding]; other site 1144275005148 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1144275005149 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1144275005150 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1144275005151 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1144275005152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1144275005153 minor groove reading motif; other site 1144275005154 helix-hairpin-helix signature motif; other site 1144275005155 substrate binding pocket [chemical binding]; other site 1144275005156 active site 1144275005157 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1144275005158 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1144275005159 DNA binding and oxoG recognition site [nucleotide binding] 1144275005160 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1144275005161 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1144275005162 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1144275005163 putative ATP binding site [chemical binding]; other site 1144275005164 putative substrate interface [chemical binding]; other site 1144275005165 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1144275005166 active site 1144275005167 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275005168 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1144275005169 Maf-like protein; Region: Maf; pfam02545 1144275005170 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1144275005171 active site 1144275005172 dimer interface [polypeptide binding]; other site 1144275005173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005174 TPR motif; other site 1144275005175 binding surface 1144275005176 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 1144275005177 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1144275005178 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1144275005179 putative RNA binding site [nucleotide binding]; other site 1144275005180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275005181 S-adenosylmethionine binding site [chemical binding]; other site 1144275005182 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1144275005183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005184 Family description; Region: UvrD_C_2; cl15862 1144275005185 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1144275005186 23S rRNA interface [nucleotide binding]; other site 1144275005187 L3 interface [polypeptide binding]; other site 1144275005188 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1144275005189 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1144275005190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005191 ATP binding site [chemical binding]; other site 1144275005192 Walker B motif; other site 1144275005193 RecX family; Region: RecX; cl00936 1144275005194 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1144275005195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005196 binding surface 1144275005197 TPR motif; other site 1144275005198 TPR repeat; Region: TPR_11; pfam13414 1144275005199 TPR repeat; Region: TPR_11; pfam13414 1144275005200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005201 binding surface 1144275005202 TPR motif; other site 1144275005203 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275005204 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275005205 phosphopeptide binding site; other site 1144275005206 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275005207 selenophosphate synthetase; Provisional; Region: PRK00943 1144275005208 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1144275005209 dimerization interface [polypeptide binding]; other site 1144275005210 putative ATP binding site [chemical binding]; other site 1144275005211 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1144275005212 active site 1144275005213 metal binding site [ion binding]; metal-binding site 1144275005214 ribonuclease PH; Reviewed; Region: rph; PRK00173 1144275005215 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1144275005216 oligomer interface [polypeptide binding]; other site 1144275005217 RNA binding site [nucleotide binding]; other site 1144275005218 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1144275005219 active site 1144275005220 dimerization interface [polypeptide binding]; other site 1144275005221 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275005222 RecT family; Region: RecT; cl04285 1144275005223 trigger factor; Region: tig; TIGR00115 1144275005224 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275005225 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1144275005226 Clp protease; Region: CLP_protease; pfam00574 1144275005227 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1144275005228 oligomer interface [polypeptide binding]; other site 1144275005229 active site residues [active] 1144275005230 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1144275005231 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1144275005232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005233 Walker A motif; other site 1144275005234 ATP binding site [chemical binding]; other site 1144275005235 Walker B motif; other site 1144275005236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275005237 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1144275005238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275005239 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1144275005240 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1144275005241 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1144275005242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005243 Walker A motif; other site 1144275005244 ATP binding site [chemical binding]; other site 1144275005245 Walker B motif; other site 1144275005246 arginine finger; other site 1144275005247 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1144275005248 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1144275005249 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1144275005250 peptide binding site [polypeptide binding]; other site 1144275005251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1144275005252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1144275005253 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275005254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005255 active site 1144275005256 phosphorylation site [posttranslational modification] 1144275005257 intermolecular recognition site; other site 1144275005258 dimerization interface [polypeptide binding]; other site 1144275005259 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1144275005260 BolA-like protein; Region: BolA; cl00386 1144275005261 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1144275005262 putative GSH binding site [chemical binding]; other site 1144275005263 catalytic residues [active] 1144275005264 MMPL family; Region: MMPL; pfam03176 1144275005265 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1144275005266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1144275005267 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1144275005268 DTW domain; Region: DTW; cl01221 1144275005269 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1144275005270 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 1144275005271 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1144275005272 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275005273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1144275005274 catalytic core [active] 1144275005275 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005276 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275005277 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275005278 active site 1144275005279 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275005280 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275005281 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275005282 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005283 peptide synthase; Provisional; Region: PRK12316 1144275005284 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275005285 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275005286 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005287 peptide synthase; Provisional; Region: PRK12467 1144275005288 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275005289 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275005290 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275005292 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275005293 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005294 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275005295 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275005296 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275005297 acyl-CoA synthetase; Validated; Region: PRK08308 1144275005298 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005299 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005300 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1144275005301 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275005302 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275005303 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1144275005304 TPP-binding site [chemical binding]; other site 1144275005305 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1144275005306 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1144275005307 PYR/PP interface [polypeptide binding]; other site 1144275005308 dimer interface [polypeptide binding]; other site 1144275005309 TPP binding site [chemical binding]; other site 1144275005310 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1144275005311 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 1144275005312 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275005313 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1144275005314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005315 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1144275005316 Phage capsid family; Region: Phage_capsid; pfam05065 1144275005317 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275005318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005319 NAD(P) binding site [chemical binding]; other site 1144275005320 active site 1144275005321 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1144275005322 nucleotide binding site [chemical binding]; other site 1144275005323 substrate binding site [chemical binding]; other site 1144275005324 acetyl-lysine deacetylase; Validated; Region: PRK00466 1144275005325 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275005326 metal binding site [ion binding]; metal-binding site 1144275005327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275005328 H+ Antiporter protein; Region: 2A0121; TIGR00900 1144275005329 putative substrate translocation pore; other site 1144275005330 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1144275005331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1144275005332 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275005333 active site 1144275005334 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275005335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275005336 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275005337 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275005338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275005339 active site 1144275005340 ATP binding site [chemical binding]; other site 1144275005341 substrate binding site [chemical binding]; other site 1144275005342 activation loop (A-loop); other site 1144275005343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005344 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1144275005345 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275005346 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1144275005347 Helix-turn-helix domains; Region: HTH; cl00088 1144275005348 Protein of unknown function, DUF399; Region: DUF399; cl01139 1144275005349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005350 dimer interface [polypeptide binding]; other site 1144275005351 phosphorylation site [posttranslational modification] 1144275005352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005353 ATP binding site [chemical binding]; other site 1144275005354 Mg2+ binding site [ion binding]; other site 1144275005355 G-X-G motif; other site 1144275005356 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275005357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005358 active site 1144275005359 phosphorylation site [posttranslational modification] 1144275005360 intermolecular recognition site; other site 1144275005361 dimerization interface [polypeptide binding]; other site 1144275005362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005363 dimer interface [polypeptide binding]; other site 1144275005364 phosphorylation site [posttranslational modification] 1144275005365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005366 ATP binding site [chemical binding]; other site 1144275005367 Mg2+ binding site [ion binding]; other site 1144275005368 G-X-G motif; other site 1144275005369 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 1144275005370 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275005371 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1144275005372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005373 Family description; Region: UvrD_C_2; cl15862 1144275005374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005375 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1144275005376 Family description; Region: UvrD_C_2; cl15862 1144275005377 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275005378 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1144275005379 active site 1144275005380 catalytic triad [active] 1144275005381 oxyanion hole [active] 1144275005382 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275005383 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1144275005384 ArsC family; Region: ArsC; pfam03960 1144275005385 putative ArsC-like catalytic residues; other site 1144275005386 putative TRX-like catalytic residues [active] 1144275005387 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275005388 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1144275005389 SET domain; Region: SET; cl02566 1144275005390 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1144275005391 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1144275005392 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1144275005393 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275005394 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1144275005395 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1144275005396 Family description; Region: UvrD_C_2; cl15862 1144275005397 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005398 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005399 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005400 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005401 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005402 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1144275005403 protein binding site [polypeptide binding]; other site 1144275005404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275005405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275005406 active site 1144275005407 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1144275005408 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1144275005409 putative active site [active] 1144275005410 nucleotide binding site [chemical binding]; other site 1144275005411 nudix motif; other site 1144275005412 putative metal binding site [ion binding]; other site 1144275005413 Pectic acid lyase; Region: Pec_lyase; pfam09492 1144275005414 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275005415 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1144275005416 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1144275005417 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275005418 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1144275005419 active site clefts [active] 1144275005420 zinc binding site [ion binding]; other site 1144275005421 dimer interface [polypeptide binding]; other site 1144275005422 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1144275005423 Sulfate transporter family; Region: Sulfate_transp; cl15842 1144275005424 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275005425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005426 active site 1144275005427 phosphorylation site [posttranslational modification] 1144275005428 intermolecular recognition site; other site 1144275005429 dimerization interface [polypeptide binding]; other site 1144275005430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005431 Walker A motif; other site 1144275005432 ATP binding site [chemical binding]; other site 1144275005433 Walker B motif; other site 1144275005434 arginine finger; other site 1144275005435 Helix-turn-helix domains; Region: HTH; cl00088 1144275005436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275005437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005438 dimer interface [polypeptide binding]; other site 1144275005439 phosphorylation site [posttranslational modification] 1144275005440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005441 ATP binding site [chemical binding]; other site 1144275005442 Mg2+ binding site [ion binding]; other site 1144275005443 G-X-G motif; other site 1144275005444 Family description; Region: VCBS; pfam13517 1144275005445 Family description; Region: VCBS; pfam13517 1144275005446 Family description; Region: VCBS; pfam13517 1144275005447 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1144275005448 Family description; Region: VCBS; pfam13517 1144275005449 Family description; Region: VCBS; pfam13517 1144275005450 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1144275005451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275005452 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1144275005453 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1144275005454 Predicted membrane protein [Function unknown]; Region: COG1470 1144275005455 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1144275005456 homotrimer interaction site [polypeptide binding]; other site 1144275005457 putative active site [active] 1144275005458 esterase; Provisional; Region: PRK10566 1144275005459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275005460 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1144275005461 ADP-ribose binding site [chemical binding]; other site 1144275005462 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005463 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005464 kelch-like protein; Provisional; Region: PHA03098 1144275005465 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005466 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005467 bile acid transporter; Region: bass; TIGR00841 1144275005468 Membrane transport protein; Region: Mem_trans; cl09117 1144275005469 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1144275005470 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1144275005471 mannose binding site [chemical binding]; other site 1144275005472 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1144275005473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1144275005474 Interdomain contacts; other site 1144275005475 Cytokine receptor motif; other site 1144275005476 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1144275005477 YCII-related domain; Region: YCII; cl00999 1144275005478 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1144275005479 Sulfate transporter family; Region: Sulfate_transp; cl15842 1144275005480 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1144275005481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005482 dimer interface [polypeptide binding]; other site 1144275005483 phosphorylation site [posttranslational modification] 1144275005484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005485 ATP binding site [chemical binding]; other site 1144275005486 Mg2+ binding site [ion binding]; other site 1144275005487 G-X-G motif; other site 1144275005488 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275005489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005490 active site 1144275005491 phosphorylation site [posttranslational modification] 1144275005492 intermolecular recognition site; other site 1144275005493 dimerization interface [polypeptide binding]; other site 1144275005494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005495 Walker A motif; other site 1144275005496 ATP binding site [chemical binding]; other site 1144275005497 Walker B motif; other site 1144275005498 arginine finger; other site 1144275005499 Helix-turn-helix domains; Region: HTH; cl00088 1144275005500 positive control sigma-like factor; Validated; Region: PRK06930 1144275005501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275005502 DNA binding residues [nucleotide binding] 1144275005503 dimerization interface [polypeptide binding]; other site 1144275005504 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1144275005505 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275005506 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1144275005507 active site 1144275005508 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1144275005509 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275005510 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1144275005511 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275005512 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275005513 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1144275005514 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1144275005515 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1144275005516 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1144275005517 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1144275005518 Predicted ATPase [General function prediction only]; Region: COG3899 1144275005519 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005520 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1144275005521 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1144275005522 NAD(P) binding site [chemical binding]; other site 1144275005523 catalytic residues [active] 1144275005524 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1144275005525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275005526 substrate binding site [chemical binding]; other site 1144275005527 oxyanion hole (OAH) forming residues; other site 1144275005528 trimer interface [polypeptide binding]; other site 1144275005529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005530 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1144275005531 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1144275005532 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1144275005533 dimer interface [polypeptide binding]; other site 1144275005534 active site 1144275005535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275005536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275005537 active site 1144275005538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275005539 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1144275005540 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1144275005541 active site 1144275005542 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1144275005543 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275005544 short chain dehydrogenase; Provisional; Region: PRK08278 1144275005545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005546 NAD(P) binding site [chemical binding]; other site 1144275005547 active site 1144275005548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275005549 Helix-turn-helix domains; Region: HTH; cl00088 1144275005550 enoyl-CoA hydratase; Provisional; Region: PRK08260 1144275005551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275005552 substrate binding site [chemical binding]; other site 1144275005553 oxyanion hole (OAH) forming residues; other site 1144275005554 trimer interface [polypeptide binding]; other site 1144275005555 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1144275005556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005557 NAD(P) binding site [chemical binding]; other site 1144275005558 active site 1144275005559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275005560 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275005561 active site 1144275005562 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1144275005563 Phosphotransferase enzyme family; Region: APH; pfam01636 1144275005564 putative active site [active] 1144275005565 putative substrate binding site [chemical binding]; other site 1144275005566 ATP binding site [chemical binding]; other site 1144275005567 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1144275005568 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1144275005569 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275005570 cytokinin dehydrogenase; Region: PLN02441 1144275005571 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275005572 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1144275005573 putative di-iron ligands [ion binding]; other site 1144275005574 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275005575 active site 1144275005576 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275005577 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275005578 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275005579 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1144275005580 active site 1144275005581 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1144275005582 putative NADP binding site [chemical binding]; other site 1144275005583 active site 1144275005584 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005585 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275005586 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1144275005587 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1144275005588 putative NAD(P) binding site [chemical binding]; other site 1144275005589 active site 1144275005590 YCII-related domain; Region: YCII; cl00999 1144275005591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275005592 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1144275005593 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1144275005594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005595 Walker A/P-loop; other site 1144275005596 ATP binding site [chemical binding]; other site 1144275005597 Q-loop/lid; other site 1144275005598 ABC transporter signature motif; other site 1144275005599 Walker B; other site 1144275005600 D-loop; other site 1144275005601 H-loop/switch region; other site 1144275005602 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275005603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275005604 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275005605 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1144275005606 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005607 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 1144275005608 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1144275005609 substrate binding site [chemical binding]; other site 1144275005610 active site 1144275005611 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1144275005612 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1144275005613 dimer interface [polypeptide binding]; other site 1144275005614 active site 1144275005615 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275005616 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1144275005617 substrate binding site [chemical binding]; other site 1144275005618 oxyanion hole (OAH) forming residues; other site 1144275005619 trimer interface [polypeptide binding]; other site 1144275005620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275005621 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1144275005622 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1144275005623 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1144275005624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275005625 S-adenosylmethionine binding site [chemical binding]; other site 1144275005626 Escherichia coli YdjC-like family of proteins; Region: YdjC; cd10808 1144275005627 putative active site [active] 1144275005628 YdjC motif; other site 1144275005629 Mg binding site [ion binding]; other site 1144275005630 putative homodimer interface [polypeptide binding]; other site 1144275005631 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1144275005632 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1144275005633 Ligand binding site; other site 1144275005634 Putative Catalytic site; other site 1144275005635 DXD motif; other site 1144275005636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275005637 metal binding site [ion binding]; metal-binding site 1144275005638 active site 1144275005639 I-site; other site 1144275005640 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275005641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005642 active site 1144275005643 phosphorylation site [posttranslational modification] 1144275005644 intermolecular recognition site; other site 1144275005645 dimerization interface [polypeptide binding]; other site 1144275005646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005647 dimer interface [polypeptide binding]; other site 1144275005648 phosphorylation site [posttranslational modification] 1144275005649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005650 ATP binding site [chemical binding]; other site 1144275005651 G-X-G motif; other site 1144275005652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005653 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275005654 active site 1144275005655 phosphorylation site [posttranslational modification] 1144275005656 intermolecular recognition site; other site 1144275005657 dimerization interface [polypeptide binding]; other site 1144275005658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005659 Walker A motif; other site 1144275005660 ATP binding site [chemical binding]; other site 1144275005661 Walker B motif; other site 1144275005662 arginine finger; other site 1144275005663 Helix-turn-helix domains; Region: HTH; cl00088 1144275005664 recombination factor protein RarA; Reviewed; Region: PRK13342 1144275005665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275005666 Walker A motif; other site 1144275005667 ATP binding site [chemical binding]; other site 1144275005668 Walker B motif; other site 1144275005669 arginine finger; other site 1144275005670 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1144275005671 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1144275005672 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1144275005673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275005674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275005675 active site 1144275005676 ATP binding site [chemical binding]; other site 1144275005677 substrate binding site [chemical binding]; other site 1144275005678 activation loop (A-loop); other site 1144275005679 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005680 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1144275005681 putative active site [active] 1144275005682 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1144275005683 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275005684 active site 1144275005685 metal binding site [ion binding]; metal-binding site 1144275005686 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275005687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275005688 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1144275005689 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1144275005690 active site 1144275005691 (T/H)XGH motif; other site 1144275005692 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1144275005693 Helix-turn-helix domains; Region: HTH; cl00088 1144275005694 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1144275005695 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275005696 active site 1144275005697 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1144275005698 SWIM zinc finger; Region: SWIM; cl15408 1144275005699 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1144275005700 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1144275005701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275005702 ATP binding site [chemical binding]; other site 1144275005703 putative Mg++ binding site [ion binding]; other site 1144275005704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275005705 nucleotide binding region [chemical binding]; other site 1144275005706 ATP-binding site [chemical binding]; other site 1144275005707 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1144275005708 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005709 Walker A/P-loop; other site 1144275005710 ATP binding site [chemical binding]; other site 1144275005711 Q-loop/lid; other site 1144275005712 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1144275005713 ABC transporter signature motif; other site 1144275005714 Walker B; other site 1144275005715 D-loop; other site 1144275005716 H-loop/switch region; other site 1144275005717 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1144275005718 active site 1144275005719 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275005720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275005721 metal binding site [ion binding]; metal-binding site 1144275005722 active site 1144275005723 I-site; other site 1144275005724 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1144275005725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275005726 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1144275005727 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1144275005728 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275005729 nucleotide binding region [chemical binding]; other site 1144275005730 hypothetical protein; Provisional; Region: PRK02250 1144275005731 SEC-C motif; Region: SEC-C; pfam02810 1144275005732 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1144275005733 rRNA interaction site [nucleotide binding]; other site 1144275005734 S8 interaction site; other site 1144275005735 putative laminin-1 binding site; other site 1144275005736 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1144275005737 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1144275005738 Elongation factor TS; Region: EF_TS; pfam00889 1144275005739 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1144275005740 putative nucleotide binding site [chemical binding]; other site 1144275005741 uridine monophosphate binding site [chemical binding]; other site 1144275005742 homohexameric interface [polypeptide binding]; other site 1144275005743 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1144275005744 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1144275005745 hinge region; other site 1144275005746 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in...; Region: Frataxin; cl00238 1144275005747 putative iron binding site [ion binding]; other site 1144275005748 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1144275005749 catalytic core [active] 1144275005750 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 1144275005751 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 1144275005752 FAD binding pocket [chemical binding]; other site 1144275005753 FAD binding motif [chemical binding]; other site 1144275005754 phosphate binding motif [ion binding]; other site 1144275005755 beta-alpha-beta structure motif; other site 1144275005756 NAD binding pocket [chemical binding]; other site 1144275005757 Iron coordination center [ion binding]; other site 1144275005758 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 1144275005759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275005760 S-adenosylmethionine binding site [chemical binding]; other site 1144275005761 DNA polymerase subunit Cdc27; Region: CDC27; pfam09507 1144275005762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275005763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275005764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275005765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275005766 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1144275005767 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 1144275005768 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1144275005769 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1144275005770 NADP-binding site; other site 1144275005771 homotetramer interface [polypeptide binding]; other site 1144275005772 substrate binding site [chemical binding]; other site 1144275005773 homodimer interface [polypeptide binding]; other site 1144275005774 active site 1144275005775 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1144275005776 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1144275005777 NADP-binding site; other site 1144275005778 homotetramer interface [polypeptide binding]; other site 1144275005779 substrate binding site [chemical binding]; other site 1144275005780 homodimer interface [polypeptide binding]; other site 1144275005781 active site 1144275005782 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1144275005783 Phytase; Region: Phytase; pfam02333 1144275005784 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1144275005785 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275005786 active site 1144275005787 metal binding site [ion binding]; metal-binding site 1144275005788 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275005789 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1144275005790 DNA-K related protein; Region: DUF3731; pfam12531 1144275005791 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1144275005792 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 1144275005793 TPR repeat; Region: TPR_11; pfam13414 1144275005794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005795 binding surface 1144275005796 TPR motif; other site 1144275005797 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275005798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005799 binding surface 1144275005800 TPR motif; other site 1144275005801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005802 TPR motif; other site 1144275005803 binding surface 1144275005804 UbiA prenyltransferase family; Region: UbiA; cl00337 1144275005805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275005806 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1144275005807 Walker A/P-loop; other site 1144275005808 ATP binding site [chemical binding]; other site 1144275005809 Q-loop/lid; other site 1144275005810 ABC transporter signature motif; other site 1144275005811 Walker B; other site 1144275005812 D-loop; other site 1144275005813 H-loop/switch region; other site 1144275005814 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275005815 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275005816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275005817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275005818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005819 dimer interface [polypeptide binding]; other site 1144275005820 phosphorylation site [posttranslational modification] 1144275005821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005822 ATP binding site [chemical binding]; other site 1144275005823 Mg2+ binding site [ion binding]; other site 1144275005824 G-X-G motif; other site 1144275005825 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275005826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005827 active site 1144275005828 phosphorylation site [posttranslational modification] 1144275005829 intermolecular recognition site; other site 1144275005830 dimerization interface [polypeptide binding]; other site 1144275005831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275005832 DNA binding site [nucleotide binding] 1144275005833 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1144275005834 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1144275005835 DNA-binding site [nucleotide binding]; DNA binding site 1144275005836 RNA-binding motif; other site 1144275005837 Cupin domain; Region: Cupin_2; cl09118 1144275005838 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275005839 active site 1144275005840 metal binding site [ion binding]; metal-binding site 1144275005841 DoxX; Region: DoxX; cl00976 1144275005842 Helix-turn-helix domains; Region: HTH; cl00088 1144275005843 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1144275005844 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1144275005845 DTW domain; Region: DTW; cl01221 1144275005846 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1144275005847 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275005848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275005849 motif II; other site 1144275005850 hypothetical protein; Provisional; Region: PRK08262 1144275005851 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 1144275005852 metal binding site [ion binding]; metal-binding site 1144275005853 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275005854 OpgC protein; Region: OpgC_C; cl00792 1144275005855 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1144275005856 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275005857 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1144275005858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275005859 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1144275005860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275005861 Isochorismatase family; Region: Isochorismatase; pfam00857 1144275005862 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1144275005863 catalytic triad [active] 1144275005864 dimer interface [polypeptide binding]; other site 1144275005865 conserved cis-peptide bond; other site 1144275005866 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1144275005867 MAPEG family; Region: MAPEG; cl09190 1144275005868 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1144275005869 Helix-turn-helix domains; Region: HTH; cl00088 1144275005870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1144275005871 dimerization interface [polypeptide binding]; other site 1144275005872 acetolactate synthase; Reviewed; Region: PRK08322 1144275005873 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1144275005874 PYR/PP interface [polypeptide binding]; other site 1144275005875 dimer interface [polypeptide binding]; other site 1144275005876 TPP binding site [chemical binding]; other site 1144275005877 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1144275005878 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1144275005879 TPP-binding site [chemical binding]; other site 1144275005880 dimer interface [polypeptide binding]; other site 1144275005881 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275005882 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 1144275005883 NAD(P) binding site [chemical binding]; other site 1144275005884 catalytic residues [active] 1144275005885 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1144275005886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275005887 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 1144275005888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275005889 ATP binding site [chemical binding]; other site 1144275005890 putative Mg++ binding site [ion binding]; other site 1144275005891 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275005892 nucleotide binding region [chemical binding]; other site 1144275005893 ATP-binding site [chemical binding]; other site 1144275005894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275005895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275005896 Histidine kinase; Region: His_kinase; pfam06580 1144275005897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005898 ATP binding site [chemical binding]; other site 1144275005899 Mg2+ binding site [ion binding]; other site 1144275005900 G-X-G motif; other site 1144275005901 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1144275005902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005903 active site 1144275005904 phosphorylation site [posttranslational modification] 1144275005905 intermolecular recognition site; other site 1144275005906 dimerization interface [polypeptide binding]; other site 1144275005907 LytTr DNA-binding domain; Region: LytTR; cl04498 1144275005908 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275005909 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275005910 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275005911 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275005912 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275005913 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275005914 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275005915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275005916 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1144275005917 active site 1144275005918 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1144275005919 putative ligand binding site [chemical binding]; other site 1144275005920 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275005921 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1144275005922 hypothetical protein; Provisional; Region: PHA03169 1144275005923 tellurite resistance protein terB; Region: terB; cd07176 1144275005924 putative metal binding site [ion binding]; other site 1144275005925 kelch-like protein; Provisional; Region: PHA03098 1144275005926 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005927 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005928 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275005929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275005930 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275005931 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1144275005932 DNA binding site [nucleotide binding] 1144275005933 active site 1144275005934 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1144275005935 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1144275005936 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1144275005937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275005938 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1144275005939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275005940 DNA binding residues [nucleotide binding] 1144275005941 DNA primase, catalytic core; Region: dnaG; TIGR01391 1144275005942 CHC2 zinc finger; Region: zf-CHC2; cl15369 1144275005943 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1144275005944 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1144275005945 active site 1144275005946 metal binding site [ion binding]; metal-binding site 1144275005947 interdomain interaction site; other site 1144275005948 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1144275005949 GatB domain; Region: GatB_Yqey; cl11497 1144275005950 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1144275005951 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1144275005952 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275005953 phosphopeptide binding site; other site 1144275005954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275005955 metal binding site [ion binding]; metal-binding site 1144275005956 active site 1144275005957 I-site; other site 1144275005958 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1144275005959 homodimer interface [polypeptide binding]; other site 1144275005960 active site 1144275005961 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275005962 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1144275005963 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275005964 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 1144275005965 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1144275005966 Permutation of conserved domain; other site 1144275005967 active site 1144275005968 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1144275005969 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275005970 ligand binding site [chemical binding]; other site 1144275005971 HEAT repeats; Region: HEAT_2; pfam13646 1144275005972 HEAT repeats; Region: HEAT_2; pfam13646 1144275005973 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1144275005974 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275005975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275005976 active site 1144275005977 phosphorylation site [posttranslational modification] 1144275005978 intermolecular recognition site; other site 1144275005979 dimerization interface [polypeptide binding]; other site 1144275005980 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1144275005981 30S subunit binding site; other site 1144275005982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275005983 dimerization interface [polypeptide binding]; other site 1144275005984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275005985 dimer interface [polypeptide binding]; other site 1144275005986 phosphorylation site [posttranslational modification] 1144275005987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275005988 ATP binding site [chemical binding]; other site 1144275005989 Mg2+ binding site [ion binding]; other site 1144275005990 G-X-G motif; other site 1144275005991 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1144275005992 Transglycosylase; Region: Transgly; cl07896 1144275005993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275005994 TPR repeat; Region: TPR_11; pfam13414 1144275005995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275005996 binding surface 1144275005997 TPR motif; other site 1144275005998 TPR repeat; Region: TPR_11; pfam13414 1144275005999 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1144275006000 putative catalytic site [active] 1144275006001 putative phosphate binding site [ion binding]; other site 1144275006002 active site 1144275006003 metal binding site A [ion binding]; metal-binding site 1144275006004 DNA binding site [nucleotide binding] 1144275006005 putative AP binding site [nucleotide binding]; other site 1144275006006 putative metal binding site B [ion binding]; other site 1144275006007 threonine synthase; Validated; Region: PRK08197 1144275006008 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1144275006009 homodimer interface [polypeptide binding]; other site 1144275006010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275006011 catalytic residue [active] 1144275006012 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275006013 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1144275006014 putative alpha-glucosidase; Provisional; Region: PRK10658 1144275006015 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1144275006016 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1144275006017 trimer interface [polypeptide binding]; other site 1144275006018 active site 1144275006019 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1144275006020 catalytic site [active] 1144275006021 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275006022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006023 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275006024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275006025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275006026 dimer interface [polypeptide binding]; other site 1144275006027 phosphorylation site [posttranslational modification] 1144275006028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275006029 ATP binding site [chemical binding]; other site 1144275006030 Mg2+ binding site [ion binding]; other site 1144275006031 G-X-G motif; other site 1144275006032 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275006033 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1144275006034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275006035 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1144275006036 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1144275006037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006038 active site 1144275006039 phosphorylation site [posttranslational modification] 1144275006040 intermolecular recognition site; other site 1144275006041 dimerization interface [polypeptide binding]; other site 1144275006042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275006043 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275006044 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275006045 putative active site [active] 1144275006046 heme pocket [chemical binding]; other site 1144275006047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275006048 dimer interface [polypeptide binding]; other site 1144275006049 phosphorylation site [posttranslational modification] 1144275006050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275006051 ATP binding site [chemical binding]; other site 1144275006052 Mg2+ binding site [ion binding]; other site 1144275006053 G-X-G motif; other site 1144275006054 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275006055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006056 active site 1144275006057 phosphorylation site [posttranslational modification] 1144275006058 intermolecular recognition site; other site 1144275006059 dimerization interface [polypeptide binding]; other site 1144275006060 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275006061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006062 active site 1144275006063 phosphorylation site [posttranslational modification] 1144275006064 intermolecular recognition site; other site 1144275006065 dimerization interface [polypeptide binding]; other site 1144275006066 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275006067 putative binding surface; other site 1144275006068 active site 1144275006069 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 1144275006070 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1144275006071 GIY-YIG motif/motif A; other site 1144275006072 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275006073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006074 active site 1144275006075 phosphorylation site [posttranslational modification] 1144275006076 intermolecular recognition site; other site 1144275006077 dimerization interface [polypeptide binding]; other site 1144275006078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006079 Walker A motif; other site 1144275006080 ATP binding site [chemical binding]; other site 1144275006081 Walker B motif; other site 1144275006082 arginine finger; other site 1144275006083 Helix-turn-helix domains; Region: HTH; cl00088 1144275006084 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275006085 ligand binding site [chemical binding]; other site 1144275006086 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275006087 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275006088 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275006089 dimer interface [polypeptide binding]; other site 1144275006090 putative CheW interface [polypeptide binding]; other site 1144275006091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275006092 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275006093 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275006094 dimer interface [polypeptide binding]; other site 1144275006095 putative CheW interface [polypeptide binding]; other site 1144275006096 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275006097 putative binding surface; other site 1144275006098 active site 1144275006099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275006100 ATP binding site [chemical binding]; other site 1144275006101 Mg2+ binding site [ion binding]; other site 1144275006102 G-X-G motif; other site 1144275006103 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275006104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006105 active site 1144275006106 phosphorylation site [posttranslational modification] 1144275006107 intermolecular recognition site; other site 1144275006108 dimerization interface [polypeptide binding]; other site 1144275006109 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1144275006110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006111 active site 1144275006112 phosphorylation site [posttranslational modification] 1144275006113 intermolecular recognition site; other site 1144275006114 dimerization interface [polypeptide binding]; other site 1144275006115 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275006116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275006117 proteasome ATPase; Region: pup_AAA; TIGR03689 1144275006118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275006119 binding surface 1144275006120 TPR motif; other site 1144275006121 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275006122 active site 1144275006123 metal binding site [ion binding]; metal-binding site 1144275006124 peptide synthase; Provisional; Region: PRK12316 1144275006125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006126 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006127 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006128 peptide synthase; Provisional; Region: PRK12467 1144275006129 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006130 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006131 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006132 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006133 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006134 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006135 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006136 peptide synthase; Provisional; Region: PRK12316 1144275006137 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006138 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006139 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006140 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006141 peptide synthase; Provisional; Region: PRK12467 1144275006142 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006143 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006144 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006145 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006146 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006147 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006148 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006149 peptide synthase; Provisional; Region: PRK12316 1144275006150 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006151 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006152 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006153 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006154 peptide synthase; Provisional; Region: PRK12467 1144275006155 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006156 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006157 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006158 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1144275006159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275006160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275006161 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 1144275006162 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 1144275006163 active site 1144275006164 Zn binding site [ion binding]; other site 1144275006165 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 1144275006166 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1144275006167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006168 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1144275006169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275006170 substrate binding site [chemical binding]; other site 1144275006171 oxyanion hole (OAH) forming residues; other site 1144275006172 trimer interface [polypeptide binding]; other site 1144275006173 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1144275006174 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1144275006175 dimer interface [polypeptide binding]; other site 1144275006176 active site 1144275006177 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 1144275006178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275006179 Walker A/P-loop; other site 1144275006180 ATP binding site [chemical binding]; other site 1144275006181 Q-loop/lid; other site 1144275006182 ABC transporter signature motif; other site 1144275006183 Walker B; other site 1144275006184 D-loop; other site 1144275006185 H-loop/switch region; other site 1144275006186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275006187 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1144275006188 ligand binding site [chemical binding]; other site 1144275006189 flexible hinge region; other site 1144275006190 Helix-turn-helix domains; Region: HTH; cl00088 1144275006191 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275006192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006193 active site 1144275006194 phosphorylation site [posttranslational modification] 1144275006195 intermolecular recognition site; other site 1144275006196 dimerization interface [polypeptide binding]; other site 1144275006197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006198 Walker A motif; other site 1144275006199 ATP binding site [chemical binding]; other site 1144275006200 Walker B motif; other site 1144275006201 arginine finger; other site 1144275006202 Helix-turn-helix domains; Region: HTH; cl00088 1144275006203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275006204 dimer interface [polypeptide binding]; other site 1144275006205 phosphorylation site [posttranslational modification] 1144275006206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275006207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275006208 S-adenosylmethionine binding site [chemical binding]; other site 1144275006209 SmpA / OmlA family; Region: SmpA_OmlA; cl01095 1144275006210 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1144275006211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275006212 active site 1144275006213 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1144275006214 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1144275006215 putative RNA binding site [nucleotide binding]; other site 1144275006216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275006217 S-adenosylmethionine binding site [chemical binding]; other site 1144275006218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275006219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275006220 active site 1144275006221 ATP binding site [chemical binding]; other site 1144275006222 substrate binding site [chemical binding]; other site 1144275006223 activation loop (A-loop); other site 1144275006224 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1144275006225 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1144275006226 dimerization interface 3.5A [polypeptide binding]; other site 1144275006227 active site 1144275006228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006229 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1144275006230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275006231 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1144275006232 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1144275006233 Ligand Binding Site [chemical binding]; other site 1144275006234 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1144275006235 active sites [active] 1144275006236 Lyase; Region: Lyase_1; pfam00206 1144275006237 tetramer interface [polypeptide binding]; other site 1144275006238 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1144275006239 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275006240 metal binding site [ion binding]; metal-binding site 1144275006241 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1144275006242 nucleotide binding site [chemical binding]; other site 1144275006243 substrate binding site [chemical binding]; other site 1144275006244 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 1144275006245 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1144275006246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006247 Arginine repressor [Transcription]; Region: ArgR; COG1438 1144275006248 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1144275006249 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1144275006250 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1144275006251 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1144275006252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006253 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1144275006254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275006255 active site 1144275006256 ATP binding site [chemical binding]; other site 1144275006257 substrate binding site [chemical binding]; other site 1144275006258 activation loop (A-loop); other site 1144275006259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006260 binding surface 1144275006261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006262 TPR motif; other site 1144275006263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006265 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275006266 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275006267 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1144275006268 dimer interface [polypeptide binding]; other site 1144275006269 N-terminal domain interface [polypeptide binding]; other site 1144275006270 substrate binding pocket (H-site) [chemical binding]; other site 1144275006271 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1144275006272 Clp amino terminal domain; Region: Clp_N; pfam02861 1144275006273 Clp amino terminal domain; Region: Clp_N; pfam02861 1144275006274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006275 Walker A motif; other site 1144275006276 ATP binding site [chemical binding]; other site 1144275006277 Walker B motif; other site 1144275006278 arginine finger; other site 1144275006279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006280 Walker A motif; other site 1144275006281 ATP binding site [chemical binding]; other site 1144275006282 Walker B motif; other site 1144275006283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275006284 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 1144275006285 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1144275006286 thiamine phosphate binding site [chemical binding]; other site 1144275006287 active site 1144275006288 pyrophosphate binding site [ion binding]; other site 1144275006289 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1144275006290 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1144275006291 catalytic triad [active] 1144275006292 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1144275006293 substrate binding site [chemical binding]; other site 1144275006294 ATP binding site [chemical binding]; other site 1144275006295 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1144275006296 replicative DNA helicase; Region: DnaB; TIGR00665 1144275006297 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1144275006298 Walker A motif; other site 1144275006299 ATP binding site [chemical binding]; other site 1144275006300 Walker B motif; other site 1144275006301 DNA binding loops [nucleotide binding] 1144275006302 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1144275006303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006304 active site 1144275006305 phosphorylation site [posttranslational modification] 1144275006306 intermolecular recognition site; other site 1144275006307 dimerization interface [polypeptide binding]; other site 1144275006308 LytTr DNA-binding domain; Region: LytTR; cl04498 1144275006309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275006310 Histidine kinase; Region: His_kinase; pfam06580 1144275006311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275006312 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1144275006313 OpgC protein; Region: OpgC_C; cl00792 1144275006314 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1144275006315 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1144275006316 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1144275006317 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 1144275006318 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1144275006319 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1144275006320 putative active site [active] 1144275006321 catalytic residue [active] 1144275006322 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1144275006323 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1144275006324 5S rRNA interface [nucleotide binding]; other site 1144275006325 CTC domain interface [polypeptide binding]; other site 1144275006326 L16 interface [polypeptide binding]; other site 1144275006327 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1144275006328 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1144275006329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275006330 active site 1144275006331 SpoVG; Region: SpoVG; cl00915 1144275006332 thymidine kinase; Provisional; Region: PRK04296 1144275006333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1144275006334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275006335 active site 1144275006336 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1144275006337 amphipathic channel; other site 1144275006338 Asn-Pro-Ala signature motifs; other site 1144275006339 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1144275006340 dimer interface [polypeptide binding]; other site 1144275006341 putative radical transfer pathway; other site 1144275006342 diiron center [ion binding]; other site 1144275006343 tyrosyl radical; other site 1144275006344 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 1144275006345 ATP cone domain; Region: ATP-cone; pfam03477 1144275006346 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1144275006347 active site 1144275006348 dimer interface [polypeptide binding]; other site 1144275006349 catalytic residues [active] 1144275006350 effector binding site; other site 1144275006351 R2 peptide binding site; other site 1144275006352 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275006353 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275006354 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1144275006355 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1144275006356 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1144275006357 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275006358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006359 active site 1144275006360 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1144275006361 phosphorylation site [posttranslational modification] 1144275006362 intermolecular recognition site; other site 1144275006363 dimerization interface [polypeptide binding]; other site 1144275006364 GAF domain; Region: GAF; cl15785 1144275006365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275006366 metal binding site [ion binding]; metal-binding site 1144275006367 active site 1144275006368 I-site; other site 1144275006369 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006371 active site 1144275006372 phosphorylation site [posttranslational modification] 1144275006373 intermolecular recognition site; other site 1144275006374 dimerization interface [polypeptide binding]; other site 1144275006375 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275006376 Cytochrome P450; Region: p450; pfam00067 1144275006377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275006378 Cytochrome P450; Region: p450; pfam00067 1144275006379 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275006380 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1144275006381 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275006382 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275006383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006384 binding surface 1144275006385 TPR motif; other site 1144275006386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006387 binding surface 1144275006388 TPR motif; other site 1144275006389 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275006390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006391 TPR motif; other site 1144275006392 binding surface 1144275006393 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275006394 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275006395 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275006396 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275006397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275006398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275006399 dimerization interface [polypeptide binding]; other site 1144275006400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275006401 dimer interface [polypeptide binding]; other site 1144275006402 phosphorylation site [posttranslational modification] 1144275006403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275006404 ATP binding site [chemical binding]; other site 1144275006405 Mg2+ binding site [ion binding]; other site 1144275006406 G-X-G motif; other site 1144275006407 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275006408 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275006409 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1144275006410 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1144275006411 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1144275006412 Cupin domain; Region: Cupin_2; cl09118 1144275006413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275006414 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275006415 short chain dehydrogenase; Provisional; Region: PRK06179 1144275006416 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1144275006417 NADP binding site [chemical binding]; other site 1144275006418 active site 1144275006419 steroid binding site; other site 1144275006420 Peptidase family M48; Region: Peptidase_M48; cl12018 1144275006421 DsrE/DsrF-like family; Region: DrsE; cl00672 1144275006422 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1144275006423 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1144275006424 homotetramer interface [polypeptide binding]; other site 1144275006425 FMN binding site [chemical binding]; other site 1144275006426 homodimer contacts [polypeptide binding]; other site 1144275006427 putative active site [active] 1144275006428 putative substrate binding site [chemical binding]; other site 1144275006429 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1144275006430 homodimer interface [polypeptide binding]; other site 1144275006431 catalytic residues [active] 1144275006432 NAD binding site [chemical binding]; other site 1144275006433 substrate binding pocket [chemical binding]; other site 1144275006434 flexible flap; other site 1144275006435 mevalonate kinase; Region: mevalon_kin; TIGR00549 1144275006436 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1144275006437 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1144275006438 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275006439 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1144275006440 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1144275006441 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275006442 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1144275006443 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 1144275006444 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275006445 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1144275006446 HSP70 interaction site [polypeptide binding]; other site 1144275006447 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1144275006448 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1144275006449 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1144275006450 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1144275006451 trimerization site [polypeptide binding]; other site 1144275006452 active site 1144275006453 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275006454 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1144275006455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275006456 catalytic residue [active] 1144275006457 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1144275006458 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1144275006459 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275006460 DTW domain; Region: DTW; cl01221 1144275006461 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275006462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275006463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275006464 Putative zinc-finger; Region: zf-HC2; cl15806 1144275006465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006466 binding surface 1144275006467 TPR motif; other site 1144275006468 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1144275006469 active site 1144275006470 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1144275006471 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1144275006472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006473 Walker A motif; other site 1144275006474 ATP binding site [chemical binding]; other site 1144275006475 Walker B motif; other site 1144275006476 arginine finger; other site 1144275006477 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1144275006478 hypothetical protein; Reviewed; Region: PRK09588 1144275006479 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1144275006480 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...; Region: RNA_Cyclase_Class_II; cd00874 1144275006481 putative active site [active] 1144275006482 adenylation catalytic residue [active] 1144275006483 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1144275006484 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1144275006485 DNA binding site [nucleotide binding] 1144275006486 H2TH interface [polypeptide binding]; other site 1144275006487 putative catalytic residues [active] 1144275006488 turnover-facilitating residue; other site 1144275006489 8OG recognition residue [nucleotide binding]; other site 1144275006490 putative reading head residues; other site 1144275006491 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1144275006492 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1144275006493 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275006494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006495 active site 1144275006496 phosphorylation site [posttranslational modification] 1144275006497 intermolecular recognition site; other site 1144275006498 dimerization interface [polypeptide binding]; other site 1144275006499 Transcriptional regulator; Region: Transcrip_reg; cl00361 1144275006500 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1144275006501 active site 1144275006502 putative DNA-binding cleft [nucleotide binding]; other site 1144275006503 dimer interface [polypeptide binding]; other site 1144275006504 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1144275006505 RuvA N terminal domain; Region: RuvA_N; pfam01330 1144275006506 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1144275006507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275006508 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1144275006509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006510 Walker A motif; other site 1144275006511 ATP binding site [chemical binding]; other site 1144275006512 Walker B motif; other site 1144275006513 arginine finger; other site 1144275006514 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1144275006515 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1144275006516 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1144275006517 SurA N-terminal domain; Region: SurA_N_3; cl07813 1144275006518 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275006519 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1144275006520 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275006521 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1144275006522 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1144275006523 interface (dimer of trimers) [polypeptide binding]; other site 1144275006524 Substrate-binding/catalytic site; other site 1144275006525 Zn-binding sites [ion binding]; other site 1144275006526 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1144275006527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006529 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275006531 non-specific DNA binding site [nucleotide binding]; other site 1144275006532 salt bridge; other site 1144275006533 sequence-specific DNA binding site [nucleotide binding]; other site 1144275006534 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1144275006535 Domain of unknown function (DUF955); Region: DUF955; cl01076 1144275006536 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1144275006537 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1144275006538 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1144275006539 dimer interface [polypeptide binding]; other site 1144275006540 active site 1144275006541 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275006542 CoenzymeA binding site [chemical binding]; other site 1144275006543 subunit interaction site [polypeptide binding]; other site 1144275006544 PHB binding site; other site 1144275006545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275006546 Helix-turn-helix domains; Region: HTH; cl00088 1144275006547 YceI-like domain; Region: YceI; cl01001 1144275006548 Protein of unknown function (DUF692); Region: DUF692; cl01263 1144275006549 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 1144275006550 selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082 1144275006551 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 1144275006552 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1144275006553 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1144275006554 active site 1144275006555 Zn binding site [ion binding]; other site 1144275006556 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1144275006557 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1144275006558 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275006559 FeS/SAM binding site; other site 1144275006560 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1144275006561 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1144275006562 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1144275006563 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1144275006564 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1144275006565 catalytic site [active] 1144275006566 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1144275006567 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1144275006568 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1144275006569 hinge; other site 1144275006570 active site 1144275006571 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1144275006572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275006573 S-adenosylmethionine binding site [chemical binding]; other site 1144275006574 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1144275006575 RF-1 domain; Region: RF-1; cl02875 1144275006576 RF-1 domain; Region: RF-1; cl02875 1144275006577 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1144275006578 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1144275006579 putative active site [active] 1144275006580 putative metal binding site [ion binding]; other site 1144275006581 TPR repeat; Region: TPR_11; pfam13414 1144275006582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006583 binding surface 1144275006584 TPR motif; other site 1144275006585 TPR repeat; Region: TPR_11; pfam13414 1144275006586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006587 binding surface 1144275006588 TPR motif; other site 1144275006589 TPR repeat; Region: TPR_11; pfam13414 1144275006590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006591 binding surface 1144275006592 TPR motif; other site 1144275006593 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1144275006594 Domain of unknown function DUF21; Region: DUF21; pfam01595 1144275006595 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1144275006596 Transporter associated domain; Region: CorC_HlyC; cl08393 1144275006597 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1144275006598 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275006599 NAD binding site [chemical binding]; other site 1144275006600 catalytic Zn binding site [ion binding]; other site 1144275006601 structural Zn binding site [ion binding]; other site 1144275006602 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1144275006603 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275006604 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1144275006605 Walker A/P-loop; other site 1144275006606 ATP binding site [chemical binding]; other site 1144275006607 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1144275006608 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1144275006609 ABC transporter signature motif; other site 1144275006610 Walker B; other site 1144275006611 D-loop; other site 1144275006612 H-loop/switch region; other site 1144275006613 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275006614 phosphopeptide binding site; other site 1144275006615 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275006616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006617 Walker A motif; other site 1144275006618 ATP binding site [chemical binding]; other site 1144275006619 Walker B motif; other site 1144275006620 arginine finger; other site 1144275006621 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1144275006622 GSH binding site [chemical binding]; other site 1144275006623 catalytic residues [active] 1144275006624 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1144275006625 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1144275006626 ring oligomerisation interface [polypeptide binding]; other site 1144275006627 ATP/Mg binding site [chemical binding]; other site 1144275006628 stacking interactions; other site 1144275006629 hinge regions; other site 1144275006630 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1144275006631 oligomerisation interface [polypeptide binding]; other site 1144275006632 mobile loop; other site 1144275006633 roof hairpin; other site 1144275006634 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1144275006635 active site 1144275006636 Ap6A binding site [chemical binding]; other site 1144275006637 nudix motif; other site 1144275006638 metal binding site [ion binding]; metal-binding site 1144275006639 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1144275006640 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1144275006641 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1144275006642 NADP binding site [chemical binding]; other site 1144275006643 Predicted membrane protein [Function unknown]; Region: COG4270 1144275006644 phosphoglucomutase; Validated; Region: PRK07564 1144275006645 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1144275006646 active site 1144275006647 substrate binding site [chemical binding]; other site 1144275006648 metal binding site [ion binding]; metal-binding site 1144275006649 muropeptide transporter; Validated; Region: ampG; PRK11010 1144275006650 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1144275006651 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275006652 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1144275006653 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275006654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275006655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275006656 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275006657 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275006658 active site 1144275006659 metal binding site [ion binding]; metal-binding site 1144275006660 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1144275006661 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1144275006662 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1144275006663 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1144275006664 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1144275006665 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275006666 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1144275006667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275006668 Walker A/P-loop; other site 1144275006669 ATP binding site [chemical binding]; other site 1144275006670 Q-loop/lid; other site 1144275006671 ABC transporter signature motif; other site 1144275006672 Walker B; other site 1144275006673 D-loop; other site 1144275006674 H-loop/switch region; other site 1144275006675 aspartate kinase; Reviewed; Region: PRK06635 1144275006676 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1144275006677 putative catalytic residues [active] 1144275006678 putative nucleotide binding site [chemical binding]; other site 1144275006679 putative aspartate binding site [chemical binding]; other site 1144275006680 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275006681 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 1144275006682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275006683 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275006684 Walker A motif; other site 1144275006685 ATP binding site [chemical binding]; other site 1144275006686 Walker B motif; other site 1144275006687 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275006688 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275006689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1144275006690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1144275006691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275006692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006693 binding surface 1144275006694 TPR motif; other site 1144275006695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006696 TPR motif; other site 1144275006697 binding surface 1144275006698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006699 binding surface 1144275006700 TPR motif; other site 1144275006701 TPR repeat; Region: TPR_11; pfam13414 1144275006702 Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780 1144275006703 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275006704 phosphopeptide binding site; other site 1144275006705 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275006706 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275006707 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275006708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006709 binding surface 1144275006710 TPR motif; other site 1144275006711 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275006712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006713 binding surface 1144275006714 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275006715 TPR motif; other site 1144275006716 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275006717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006718 binding surface 1144275006719 TPR motif; other site 1144275006720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006721 binding surface 1144275006722 TPR motif; other site 1144275006723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275006724 binding surface 1144275006725 TPR motif; other site 1144275006726 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1144275006727 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1144275006728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275006729 Predicted membrane protein [Function unknown]; Region: COG1470 1144275006730 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275006731 Bacterial Ig-like domain; Region: Big_5; cl01012 1144275006732 signal recognition particle protein; Provisional; Region: PRK10867 1144275006733 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1144275006734 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1144275006735 P loop; other site 1144275006736 GTP binding site [chemical binding]; other site 1144275006737 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1144275006738 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1144275006739 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1144275006740 glutamine binding [chemical binding]; other site 1144275006741 catalytic triad [active] 1144275006742 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1144275006743 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1144275006744 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1144275006745 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275006746 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275006747 active site 1144275006748 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275006749 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275006750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006751 NAD(P) binding site [chemical binding]; other site 1144275006752 active site 1144275006753 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006754 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1144275006755 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275006756 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275006757 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006758 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1144275006759 putative NADP binding site [chemical binding]; other site 1144275006760 active site 1144275006761 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006762 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006763 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1144275006764 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275006765 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1144275006766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006767 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1144275006768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275006769 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275006770 active site 1144275006771 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275006772 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275006773 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006774 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1144275006775 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1144275006776 inhibitor-cofactor binding pocket; inhibition site 1144275006777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275006778 catalytic residue [active] 1144275006779 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1144275006780 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275006781 peptide synthase; Provisional; Region: PRK12316 1144275006782 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006783 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006784 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006785 peptide synthase; Provisional; Region: PRK12467 1144275006786 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1144275006787 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006788 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006789 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275006790 putative chaperone; Provisional; Region: PRK11678 1144275006791 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275006792 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1144275006793 putative NAD(P) binding site [chemical binding]; other site 1144275006794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275006795 ATP binding site [chemical binding]; other site 1144275006796 putative Mg++ binding site [ion binding]; other site 1144275006797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275006798 nucleotide binding region [chemical binding]; other site 1144275006799 ATP-binding site [chemical binding]; other site 1144275006800 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1144275006801 hypothetical protein; Validated; Region: PRK08238 1144275006802 UbiA prenyltransferase family; Region: UbiA; cl00337 1144275006803 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1144275006804 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275006805 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275006806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275006807 NAD(P) binding site [chemical binding]; other site 1144275006808 active site 1144275006809 peptide synthase; Provisional; Region: PRK12467 1144275006810 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006811 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006812 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006813 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006814 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006815 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006816 peptide synthase; Provisional; Region: PRK12467 1144275006817 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006818 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006819 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006820 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006821 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006822 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006823 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006824 peptide synthase; Provisional; Region: PRK12467 1144275006825 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006826 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006827 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006828 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006829 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006830 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006831 peptide synthase; Provisional; Region: PRK12467 1144275006832 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006833 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006834 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006835 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006836 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006837 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006838 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006839 peptide synthase; Provisional; Region: PRK12467 1144275006840 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006841 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006842 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006843 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275006844 peptide synthase; Provisional; Region: PRK12467 1144275006845 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006846 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006847 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006848 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006849 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006850 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006851 peptide synthase; Provisional; Region: PRK12316 1144275006852 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006853 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006854 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006855 peptide synthase; Provisional; Region: PRK12467 1144275006856 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006857 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006858 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006859 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006860 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006861 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006862 peptide synthase; Provisional; Region: PRK12316 1144275006863 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006864 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006865 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006866 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006867 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275006868 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006869 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006870 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006871 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006872 peptide synthase; Provisional; Region: PRK12467 1144275006873 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006874 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006875 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006876 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006877 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006878 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006879 peptide synthase; Provisional; Region: PRK12467 1144275006880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006881 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006882 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006883 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006884 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006885 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006886 peptide synthase; Provisional; Region: PRK12316 1144275006887 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006888 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006889 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006890 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006891 peptide synthase; Provisional; Region: PRK12467 1144275006892 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006893 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006894 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006895 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006896 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006897 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006898 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006899 peptide synthase; Provisional; Region: PRK12467 1144275006900 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275006901 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275006902 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275006903 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275006904 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1144275006905 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 1144275006906 phosphatidylcholine-sterol O-acyltransferase; Region: PLN02517 1144275006907 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1144275006908 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275006909 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275006910 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1144275006911 Domain of unknown function DUF21; Region: DUF21; pfam01595 1144275006912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1144275006913 Transporter associated domain; Region: CorC_HlyC; cl08393 1144275006914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006915 active site 1144275006916 phosphorylation site [posttranslational modification] 1144275006917 intermolecular recognition site; other site 1144275006918 dimerization interface [polypeptide binding]; other site 1144275006919 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275006920 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275006921 active site 1144275006922 metal binding site [ion binding]; metal-binding site 1144275006923 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1144275006924 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1144275006925 ligand binding site; other site 1144275006926 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1144275006927 PhoU domain; Region: PhoU; pfam01895 1144275006928 PhoU domain; Region: PhoU; pfam01895 1144275006929 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 1144275006930 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1144275006931 Walker A/P-loop; other site 1144275006932 ATP binding site [chemical binding]; other site 1144275006933 Q-loop/lid; other site 1144275006934 ABC transporter signature motif; other site 1144275006935 Walker B; other site 1144275006936 D-loop; other site 1144275006937 H-loop/switch region; other site 1144275006938 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1144275006939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275006940 ABC-ATPase subunit interface; other site 1144275006941 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1144275006942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275006943 dimer interface [polypeptide binding]; other site 1144275006944 conserved gate region; other site 1144275006945 putative PBP binding loops; other site 1144275006946 ABC-ATPase subunit interface; other site 1144275006947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275006948 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1144275006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006950 active site 1144275006951 phosphorylation site [posttranslational modification] 1144275006952 intermolecular recognition site; other site 1144275006953 dimerization interface [polypeptide binding]; other site 1144275006954 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275006955 DNA binding site [nucleotide binding] 1144275006956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1144275006957 catalytic core [active] 1144275006958 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 1144275006959 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1144275006960 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1144275006961 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 1144275006962 Cl- selectivity filter; other site 1144275006963 Cl- binding residues [ion binding]; other site 1144275006964 pore gating glutamate residue; other site 1144275006965 dimer interface [polypeptide binding]; other site 1144275006966 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1144275006967 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275006968 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275006969 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275006970 active site 1144275006971 metal binding site [ion binding]; metal-binding site 1144275006972 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275006973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275006974 dimer interface [polypeptide binding]; other site 1144275006975 phosphorylation site [posttranslational modification] 1144275006976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275006977 ATP binding site [chemical binding]; other site 1144275006978 Mg2+ binding site [ion binding]; other site 1144275006979 G-X-G motif; other site 1144275006980 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1144275006981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275006982 active site 1144275006983 phosphorylation site [posttranslational modification] 1144275006984 intermolecular recognition site; other site 1144275006985 dimerization interface [polypeptide binding]; other site 1144275006986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275006987 DNA binding site [nucleotide binding] 1144275006988 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1144275006989 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 1144275006990 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1144275006991 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1144275006992 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1144275006993 dimer interface [polypeptide binding]; other site 1144275006994 active site 1144275006995 CoA binding pocket [chemical binding]; other site 1144275006996 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275006997 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275006998 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1144275006999 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1144275007000 NAD(P) binding site [chemical binding]; other site 1144275007001 homotetramer interface [polypeptide binding]; other site 1144275007002 homodimer interface [polypeptide binding]; other site 1144275007003 active site 1144275007004 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275007005 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1144275007006 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1144275007007 dimer interface [polypeptide binding]; other site 1144275007008 active site 1144275007009 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1144275007010 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1144275007011 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1144275007012 dimer interface [polypeptide binding]; other site 1144275007013 active site 1144275007014 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1144275007015 folate binding site [chemical binding]; other site 1144275007016 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1144275007017 ATP cone domain; Region: ATP-cone; pfam03477 1144275007018 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1144275007019 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1144275007020 catalytic motif [active] 1144275007021 Zn binding site [ion binding]; other site 1144275007022 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1144275007023 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1144275007024 Lumazine binding domain; Region: Lum_binding; pfam00677 1144275007025 Lumazine binding domain; Region: Lum_binding; pfam00677 1144275007026 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1144275007027 homopentamer interface [polypeptide binding]; other site 1144275007028 active site 1144275007029 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1144275007030 putative RNA binding site [nucleotide binding]; other site 1144275007031 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 1144275007032 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275007033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007034 active site 1144275007035 phosphorylation site [posttranslational modification] 1144275007036 intermolecular recognition site; other site 1144275007037 dimerization interface [polypeptide binding]; other site 1144275007038 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1144275007039 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1144275007040 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1144275007041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275007042 ATP binding site [chemical binding]; other site 1144275007043 Mg2+ binding site [ion binding]; other site 1144275007044 G-X-G motif; other site 1144275007045 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1144275007046 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275007047 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275007048 HEAT repeats; Region: HEAT_2; pfam13646 1144275007049 HEAT repeats; Region: HEAT_2; pfam13646 1144275007050 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1144275007051 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1144275007052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275007053 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1144275007054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007055 active site 1144275007056 phosphorylation site [posttranslational modification] 1144275007057 intermolecular recognition site; other site 1144275007058 dimerization interface [polypeptide binding]; other site 1144275007059 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275007060 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1144275007061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007062 active site 1144275007063 phosphorylation site [posttranslational modification] 1144275007064 intermolecular recognition site; other site 1144275007065 dimerization interface [polypeptide binding]; other site 1144275007066 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1144275007067 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275007068 Walker A/P-loop; other site 1144275007069 ATP binding site [chemical binding]; other site 1144275007070 Q-loop/lid; other site 1144275007071 ABC transporter signature motif; other site 1144275007072 Walker B; other site 1144275007073 D-loop; other site 1144275007074 H-loop/switch region; other site 1144275007075 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1144275007076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275007077 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1144275007078 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1144275007079 putative dimer interface [polypeptide binding]; other site 1144275007080 putative anticodon binding site; other site 1144275007081 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1144275007082 homodimer interface [polypeptide binding]; other site 1144275007083 motif 1; other site 1144275007084 motif 2; other site 1144275007085 active site 1144275007086 motif 3; other site 1144275007087 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1144275007088 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1144275007089 HIGH motif; other site 1144275007090 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1144275007091 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275007092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275007093 active site 1144275007094 KMSKS motif; other site 1144275007095 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1144275007096 tRNA binding surface [nucleotide binding]; other site 1144275007097 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1144275007098 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1144275007099 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1144275007100 homodimer interface [polypeptide binding]; other site 1144275007101 metal binding site [ion binding]; metal-binding site 1144275007102 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 1144275007103 homodimer interface [polypeptide binding]; other site 1144275007104 active site 1144275007105 putative chemical substrate binding site [chemical binding]; other site 1144275007106 metal binding site [ion binding]; metal-binding site 1144275007107 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275007108 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1144275007109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007110 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 1144275007111 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 1144275007112 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1144275007113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275007114 Zn2+ binding site [ion binding]; other site 1144275007115 Mg2+ binding site [ion binding]; other site 1144275007116 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1144275007117 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1144275007118 peptide chain release factor 2; Provisional; Region: PRK05589 1144275007119 RF-1 domain; Region: RF-1; cl02875 1144275007120 RF-1 domain; Region: RF-1; cl02875 1144275007121 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275007122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275007123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275007124 DNA binding residues [nucleotide binding] 1144275007125 Putative zinc-finger; Region: zf-HC2; cl15806 1144275007126 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1144275007127 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1144275007128 dimer interface [polypeptide binding]; other site 1144275007129 putative anticodon binding site; other site 1144275007130 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1144275007131 motif 1; other site 1144275007132 active site 1144275007133 motif 2; other site 1144275007134 motif 3; other site 1144275007135 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275007136 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1144275007137 FtsX-like permease family; Region: FtsX; cl15850 1144275007138 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1144275007139 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275007140 Walker A/P-loop; other site 1144275007141 ATP binding site [chemical binding]; other site 1144275007142 Q-loop/lid; other site 1144275007143 ABC transporter signature motif; other site 1144275007144 Walker B; other site 1144275007145 D-loop; other site 1144275007146 H-loop/switch region; other site 1144275007147 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275007148 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1144275007149 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275007150 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275007151 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275007152 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275007153 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275007154 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1144275007155 periplasmic chaperone; Provisional; Region: PRK10780 1144275007156 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1144275007157 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1144275007158 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1144275007159 trimer interface [polypeptide binding]; other site 1144275007160 active site 1144275007161 UDP-GlcNAc binding site [chemical binding]; other site 1144275007162 lipid binding site [chemical binding]; lipid-binding site 1144275007163 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1144275007164 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1144275007165 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1144275007166 active site 1144275007167 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 1144275007168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275007169 ligand binding site [chemical binding]; other site 1144275007170 MarC family integral membrane protein; Region: MarC; cl00919 1144275007171 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1144275007172 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1144275007173 Ligand binding site; other site 1144275007174 Putative Catalytic site; other site 1144275007175 DXD motif; other site 1144275007176 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1144275007177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275007178 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275007179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007180 active site 1144275007181 phosphorylation site [posttranslational modification] 1144275007182 intermolecular recognition site; other site 1144275007183 dimerization interface [polypeptide binding]; other site 1144275007184 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275007185 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1144275007186 TPR repeat; Region: TPR_11; pfam13414 1144275007187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275007188 binding surface 1144275007189 TPR motif; other site 1144275007190 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275007191 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275007192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007193 Walker A/P-loop; other site 1144275007194 ATP binding site [chemical binding]; other site 1144275007195 Q-loop/lid; other site 1144275007196 ABC transporter signature motif; other site 1144275007197 Walker B; other site 1144275007198 D-loop; other site 1144275007199 H-loop/switch region; other site 1144275007200 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1144275007201 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1144275007202 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1144275007203 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275007204 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275007205 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 1144275007206 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1144275007207 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1144275007208 putative ribose interaction site [chemical binding]; other site 1144275007209 putative ADP binding site [chemical binding]; other site 1144275007210 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275007211 active site 1144275007212 nucleotide binding site [chemical binding]; other site 1144275007213 HIGH motif; other site 1144275007214 KMSKS motif; other site 1144275007215 Trm112p-like protein; Region: Trm112p; cl01066 1144275007216 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1144275007217 putative active site [active] 1144275007218 hypothetical protein; Provisional; Region: PRK11820 1144275007219 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1144275007220 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1144275007221 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1144275007222 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1144275007223 catalytic site [active] 1144275007224 G-X2-G-X-G-K; other site 1144275007225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275007226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275007227 active site 1144275007228 ATP binding site [chemical binding]; other site 1144275007229 substrate binding site [chemical binding]; other site 1144275007230 activation loop (A-loop); other site 1144275007231 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275007232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1144275007233 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1144275007234 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1144275007235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275007236 FeS/SAM binding site; other site 1144275007237 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1144275007238 Stage II sporulation protein; Region: SpoIID; pfam08486 1144275007239 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1144275007240 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1144275007241 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1144275007242 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1144275007243 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 1144275007244 Preprotein translocase subunit; Region: YajC; cl00806 1144275007245 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1144275007246 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1144275007247 Protein export membrane protein; Region: SecD_SecF; cl14618 1144275007248 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1144275007249 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1144275007250 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 1144275007251 Protein export membrane protein; Region: SecD_SecF; cl14618 1144275007252 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1144275007253 DHH family; Region: DHH; pfam01368 1144275007254 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1144275007255 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275007256 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1144275007257 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1144275007258 dimer interface [polypeptide binding]; other site 1144275007259 anticodon binding site; other site 1144275007260 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1144275007261 homodimer interface [polypeptide binding]; other site 1144275007262 motif 1; other site 1144275007263 active site 1144275007264 motif 2; other site 1144275007265 GAD domain; Region: GAD; pfam02938 1144275007266 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1144275007267 active site 1144275007268 motif 3; other site 1144275007269 Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659 1144275007270 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1144275007271 JmjC domain, hydroxylase; Region: JmjC; cl15814 1144275007272 JmjC domain, hydroxylase; Region: JmjC; cl15814 1144275007273 CHAT domain; Region: CHAT; pfam12770 1144275007274 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1144275007275 putative active site [active] 1144275007276 Zn binding site [ion binding]; other site 1144275007277 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 1144275007278 Protein of unknown function (DUF1152); Region: DUF1152; pfam06626 1144275007279 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1144275007280 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275007281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275007282 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1144275007283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1144275007284 minor groove reading motif; other site 1144275007285 helix-hairpin-helix signature motif; other site 1144275007286 substrate binding pocket [chemical binding]; other site 1144275007287 active site 1144275007288 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1144275007289 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1144275007290 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1144275007291 putative active site [active] 1144275007292 metal binding site [ion binding]; metal-binding site 1144275007293 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1144275007294 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1144275007295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275007296 substrate binding site [chemical binding]; other site 1144275007297 oxyanion hole (OAH) forming residues; other site 1144275007298 trimer interface [polypeptide binding]; other site 1144275007299 Transthyretin-like family; Region: DUF290; pfam01060 1144275007300 Lipoxygenase; Region: Lipoxygenase; pfam00305 1144275007301 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 1144275007302 Lipoxygenase; Region: Lipoxygenase; pfam00305 1144275007303 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275007304 Cytochrome P450; Region: p450; pfam00067 1144275007305 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275007306 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 1144275007307 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275007308 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1144275007309 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1144275007310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275007311 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275007312 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1144275007313 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1144275007314 DNA binding site [nucleotide binding] 1144275007315 active site 1144275007316 Phospholipase B; Region: Phospholip_B; pfam04916 1144275007317 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275007318 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1144275007319 Helix-turn-helix domains; Region: HTH; cl00088 1144275007320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275007321 putative substrate translocation pore; other site 1144275007322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275007323 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1144275007324 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275007325 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1144275007326 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275007327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275007328 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1144275007329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275007330 Coenzyme A binding pocket [chemical binding]; other site 1144275007331 AmpG-like permease; Region: 2A0125; TIGR00901 1144275007332 alpha-amylase; Region: PLN02361 1144275007333 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 1144275007334 active site 1144275007335 Ca binding site [ion binding]; other site 1144275007336 catalytic site [active] 1144275007337 Alpha-amylase C-terminal beta-sheet domain; Region: Alpha-amyl_C2; cl06726 1144275007338 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1144275007339 starch-binding site 2 [chemical binding]; other site 1144275007340 starch-binding site 1 [chemical binding]; other site 1144275007341 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1144275007342 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275007343 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275007344 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275007345 Outer membrane efflux protein; Region: OEP; pfam02321 1144275007346 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275007347 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1144275007348 Helix-turn-helix domains; Region: HTH; cl00088 1144275007349 Helix-turn-helix domains; Region: HTH; cl00088 1144275007350 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1144275007351 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007352 Walker A motif; other site 1144275007353 ATP binding site [chemical binding]; other site 1144275007354 Walker B motif; other site 1144275007355 fumarate hydratase; Provisional; Region: PRK15389 1144275007356 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 1144275007357 Fumarase C-terminus; Region: Fumerase_C; cl00795 1144275007358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275007359 S-adenosylmethionine binding site [chemical binding]; other site 1144275007360 enterobactin exporter EntS; Provisional; Region: PRK10489 1144275007361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275007362 putative substrate translocation pore; other site 1144275007363 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1144275007364 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 1144275007365 Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306 1144275007366 active site 1144275007367 Zn binding site [ion binding]; other site 1144275007368 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1144275007369 catalytic triad [active] 1144275007370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007371 Walker A/P-loop; other site 1144275007372 ATP binding site [chemical binding]; other site 1144275007373 AAA domain; Region: AAA_21; pfam13304 1144275007374 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1144275007375 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 1144275007376 pantothenate kinase; Provisional; Region: PRK05439 1144275007377 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1144275007378 ATP-binding site [chemical binding]; other site 1144275007379 CoA-binding site [chemical binding]; other site 1144275007380 Mg2+-binding site [ion binding]; other site 1144275007381 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1144275007382 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1144275007383 dimer interface [polypeptide binding]; other site 1144275007384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275007385 catalytic residue [active] 1144275007386 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1144275007387 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1144275007388 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275007389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275007390 DNA-binding site [nucleotide binding]; DNA binding site 1144275007391 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275007392 Predicted membrane protein [Function unknown]; Region: COG2311 1144275007393 Protein of unknown function (DUF418); Region: DUF418; cl12135 1144275007394 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1144275007395 active site 1144275007396 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1144275007397 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275007398 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275007399 putative di-iron ligands [ion binding]; other site 1144275007400 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1144275007401 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1144275007402 iron-sulfur cluster [ion binding]; other site 1144275007403 [2Fe-2S] cluster binding site [ion binding]; other site 1144275007404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275007405 ligand binding site [chemical binding]; other site 1144275007406 flexible hinge region; other site 1144275007407 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1144275007408 Domain of unknown function (DUF955); Region: DUF955; cl01076 1144275007409 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1144275007410 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275007411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275007412 homodimer interface [polypeptide binding]; other site 1144275007413 catalytic residue [active] 1144275007414 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275007415 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1144275007416 heme binding pocket [chemical binding]; other site 1144275007417 heme ligand [chemical binding]; other site 1144275007418 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1144275007419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275007420 DNA binding residues [nucleotide binding] 1144275007421 dimerization interface [polypeptide binding]; other site 1144275007422 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 1144275007423 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 1144275007424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275007425 peptide synthase; Provisional; Region: PRK12467 1144275007426 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275007427 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275007428 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275007429 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275007430 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275007431 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275007432 acyl-CoA synthetase; Validated; Region: PRK08308 1144275007433 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275007434 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1144275007435 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275007436 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275007437 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275007438 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275007439 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275007440 active site 1144275007441 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275007442 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275007443 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275007444 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1144275007445 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275007446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275007447 catalytic residue [active] 1144275007448 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275007449 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1144275007450 LabA_like proteins; Region: LabA_like; cd06167 1144275007451 putative metal binding site [ion binding]; other site 1144275007452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275007453 Helix-turn-helix domains; Region: HTH; cl00088 1144275007454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275007455 dimerization interface [polypeptide binding]; other site 1144275007456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275007457 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1144275007458 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1144275007459 conserved cys residue [active] 1144275007460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275007461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275007462 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1144275007463 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275007464 Helix-turn-helix domains; Region: HTH; cl00088 1144275007465 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275007466 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275007467 active site 1144275007468 catalytic tetrad [active] 1144275007469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275007470 Helix-turn-helix domains; Region: HTH; cl00088 1144275007471 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275007472 putative effector binding pocket; other site 1144275007473 dimerization interface [polypeptide binding]; other site 1144275007474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275007475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275007476 NAD(P) binding site [chemical binding]; other site 1144275007477 active site 1144275007478 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 1144275007479 TadE-like protein; Region: TadE; cl10688 1144275007480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275007481 Helix-turn-helix domains; Region: HTH; cl00088 1144275007482 WHG domain; Region: WHG; pfam13305 1144275007483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275007484 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275007485 NAD(P) binding site [chemical binding]; other site 1144275007486 active site 1144275007487 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 1144275007488 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1144275007489 Cl- selectivity filter; other site 1144275007490 Cl- binding residues [ion binding]; other site 1144275007491 pore gating glutamate residue; other site 1144275007492 dimer interface [polypeptide binding]; other site 1144275007493 FOG: CBS domain [General function prediction only]; Region: COG0517 1144275007494 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1144275007495 Helix-turn-helix domains; Region: HTH; cl00088 1144275007496 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1144275007497 Helix-turn-helix domains; Region: HTH; cl00088 1144275007498 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1144275007499 dimerization interface [polypeptide binding]; other site 1144275007500 substrate binding pocket [chemical binding]; other site 1144275007501 EamA-like transporter family; Region: EamA; cl01037 1144275007502 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1144275007503 EamA-like transporter family; Region: EamA; cl01037 1144275007504 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1144275007505 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1144275007506 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 1144275007507 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275007508 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1144275007509 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1144275007510 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1144275007511 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1144275007512 metal binding site [ion binding]; metal-binding site 1144275007513 putative dimer interface [polypeptide binding]; other site 1144275007514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275007515 Helix-turn-helix domains; Region: HTH; cl00088 1144275007516 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275007517 putative effector binding pocket; other site 1144275007518 putative dimerization interface [polypeptide binding]; other site 1144275007519 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1144275007520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275007521 putative substrate translocation pore; other site 1144275007522 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1144275007523 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275007524 amidase; Provisional; Region: PRK08137 1144275007525 Amidase; Region: Amidase; cl11426 1144275007526 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1144275007527 Phage-related protein [Function unknown]; Region: COG5412 1144275007528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275007529 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275007530 Walker A motif; other site 1144275007531 ATP binding site [chemical binding]; other site 1144275007532 Walker B motif; other site 1144275007533 arginine finger; other site 1144275007534 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1144275007535 Baseplate J-like protein; Region: Baseplate_J; cl01294 1144275007536 Baseplate J-like protein; Region: Baseplate_J; cl01294 1144275007537 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1144275007538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1144275007539 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1144275007540 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1144275007541 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1144275007542 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275007543 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1144275007544 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275007545 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275007546 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1144275007547 Integrase core domain; Region: rve; cl01316 1144275007548 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275007549 ligand binding site [chemical binding]; other site 1144275007550 flexible hinge region; other site 1144275007551 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1144275007552 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1144275007553 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1144275007554 Sulfatase; Region: Sulfatase; cl10460 1144275007555 Sulfatase; Region: Sulfatase; cl10460 1144275007556 MgtC family; Region: MgtC; pfam02308 1144275007557 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1144275007558 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275007559 ATP binding site [chemical binding]; other site 1144275007560 putative Mg++ binding site [ion binding]; other site 1144275007561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275007562 nucleotide binding region [chemical binding]; other site 1144275007563 ATP-binding site [chemical binding]; other site 1144275007564 Helicase associated domain (HA2); Region: HA2; cl04503 1144275007565 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1144275007566 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1144275007567 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275007568 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1144275007569 putative C-terminal domain interface [polypeptide binding]; other site 1144275007570 putative GSH binding site (G-site) [chemical binding]; other site 1144275007571 putative dimer interface [polypeptide binding]; other site 1144275007572 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275007573 N-terminal domain interface [polypeptide binding]; other site 1144275007574 dimer interface [polypeptide binding]; other site 1144275007575 substrate binding pocket (H-site) [chemical binding]; other site 1144275007576 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1144275007577 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275007578 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275007579 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275007580 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275007581 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1144275007582 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1144275007583 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1144275007584 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275007585 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275007586 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275007587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275007588 DNA binding residues [nucleotide binding] 1144275007589 FecR protein; Region: FecR; pfam04773 1144275007590 cytokinin dehydrogenase; Region: PLN02441 1144275007591 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275007592 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 1144275007593 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275007594 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 1144275007595 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 1144275007596 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275007597 putative acyl-acceptor binding pocket; other site 1144275007598 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275007599 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275007600 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 1144275007601 active site 1144275007602 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 1144275007603 putative substrate binding site [chemical binding]; other site 1144275007604 active site 1144275007605 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1144275007606 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275007607 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275007608 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1144275007609 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1144275007610 active site 1144275007611 catalytic residues [active] 1144275007612 galactokinase; Provisional; Region: PRK05101 1144275007613 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1144275007614 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1144275007615 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1144275007616 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1144275007617 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1144275007618 Walker A/P-loop; other site 1144275007619 ATP binding site [chemical binding]; other site 1144275007620 Q-loop/lid; other site 1144275007621 ABC transporter signature motif; other site 1144275007622 Walker B; other site 1144275007623 D-loop; other site 1144275007624 H-loop/switch region; other site 1144275007625 TOBE domain; Region: TOBE_2; cl01440 1144275007626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1144275007627 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1144275007628 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1144275007629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275007630 dimer interface [polypeptide binding]; other site 1144275007631 conserved gate region; other site 1144275007632 putative PBP binding loops; other site 1144275007633 ABC-ATPase subunit interface; other site 1144275007634 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275007635 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1144275007636 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1144275007637 active site 1144275007638 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 1144275007639 putative substrate binding site [chemical binding]; other site 1144275007640 active site 1144275007641 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275007642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275007643 active site 1144275007644 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1144275007645 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275007646 DNA utilization protein GntX; Provisional; Region: PRK11595 1144275007647 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275007648 Helix-turn-helix domains; Region: HTH; cl00088 1144275007649 haloalkane dehalogenase; Provisional; Region: PRK03592 1144275007650 pectate lyase, PelA/Pel-15E family; Region: pec_lyase; TIGR02474 1144275007651 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275007652 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 1144275007653 metal binding site [ion binding]; metal-binding site 1144275007654 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1144275007655 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 1144275007656 Putative transposase; Region: Y2_Tnp; pfam04986 1144275007657 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275007658 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275007659 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1144275007660 kelch-like protein; Provisional; Region: PHA03098 1144275007661 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275007662 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275007663 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1144275007664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275007665 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1144275007666 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1144275007667 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275007668 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1144275007669 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1144275007670 putative active site [active] 1144275007671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007672 Walker A/P-loop; other site 1144275007673 ATP binding site [chemical binding]; other site 1144275007674 Q-loop/lid; other site 1144275007675 Protein of unknown function (DUF493); Region: DUF493; cl01102 1144275007676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275007677 S-adenosylmethionine binding site [chemical binding]; other site 1144275007678 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1144275007679 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275007680 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275007681 hydrophobic ligand binding site; other site 1144275007682 Protein of unknown function, DUF393; Region: DUF393; cl01136 1144275007683 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275007684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007685 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275007686 metal ion-dependent adhesion site (MIDAS); other site 1144275007687 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1144275007688 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1144275007689 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1144275007690 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1144275007691 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275007692 phosphopeptide binding site; other site 1144275007693 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1144275007694 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275007695 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275007696 active site 1144275007697 ATP binding site [chemical binding]; other site 1144275007698 substrate binding site [chemical binding]; other site 1144275007699 activation loop (A-loop); other site 1144275007700 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1144275007701 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1144275007702 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1144275007703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275007704 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1144275007705 synthetase active site [active] 1144275007706 NTP binding site [chemical binding]; other site 1144275007707 metal binding site [ion binding]; metal-binding site 1144275007708 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1144275007709 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1144275007710 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1144275007711 homotrimer interaction site [polypeptide binding]; other site 1144275007712 putative active site [active] 1144275007713 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275007714 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1144275007715 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275007716 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1144275007717 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275007718 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1144275007719 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1144275007720 CPxP motif; other site 1144275007721 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1144275007722 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275007723 Walker A/P-loop; other site 1144275007724 ATP binding site [chemical binding]; other site 1144275007725 Q-loop/lid; other site 1144275007726 ABC transporter signature motif; other site 1144275007727 Walker B; other site 1144275007728 D-loop; other site 1144275007729 H-loop/switch region; other site 1144275007730 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275007731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275007732 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275007733 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 1144275007734 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275007735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007736 active site 1144275007737 phosphorylation site [posttranslational modification] 1144275007738 intermolecular recognition site; other site 1144275007739 dimerization interface [polypeptide binding]; other site 1144275007740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275007741 metal binding site [ion binding]; metal-binding site 1144275007742 active site 1144275007743 I-site; other site 1144275007744 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275007745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007746 active site 1144275007747 phosphorylation site [posttranslational modification] 1144275007748 intermolecular recognition site; other site 1144275007749 dimerization interface [polypeptide binding]; other site 1144275007750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275007751 Walker A motif; other site 1144275007752 ATP binding site [chemical binding]; other site 1144275007753 Walker B motif; other site 1144275007754 arginine finger; other site 1144275007755 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1144275007756 Helix-turn-helix domains; Region: HTH; cl00088 1144275007757 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1144275007758 putative NAD(P) binding site [chemical binding]; other site 1144275007759 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1144275007760 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1144275007761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275007762 binding surface 1144275007763 TPR motif; other site 1144275007764 TPR repeat; Region: TPR_11; pfam13414 1144275007765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275007766 TPR motif; other site 1144275007767 binding surface 1144275007768 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1144275007769 NeuB family; Region: NeuB; cl00496 1144275007770 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1144275007771 Prephenate dehydratase; Region: PDT; pfam00800 1144275007772 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1144275007773 putative L-Phe binding site [chemical binding]; other site 1144275007774 Chorismate mutase type II; Region: CM_2; cl00693 1144275007775 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1144275007776 Prephenate dehydratase; Region: PDT; pfam00800 1144275007777 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1144275007778 putative L-Phe binding site [chemical binding]; other site 1144275007779 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1144275007780 EVE domain; Region: EVE; cl00728 1144275007781 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275007782 structural tetrad; other site 1144275007783 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1144275007784 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1144275007785 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1144275007786 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1144275007787 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1144275007788 PLD-like domain; Region: PLDc_2; pfam13091 1144275007789 putative active site [active] 1144275007790 catalytic site [active] 1144275007791 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1144275007792 PLD-like domain; Region: PLDc_2; pfam13091 1144275007793 putative active site [active] 1144275007794 catalytic site [active] 1144275007795 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1144275007796 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1144275007797 SLBB domain; Region: SLBB; pfam10531 1144275007798 Chain length determinant protein; Region: Wzz; cl15801 1144275007799 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1144275007800 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1144275007801 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275007802 Bacterial sugar transferase; Region: Bac_transf; cl00939 1144275007803 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1144275007804 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1144275007805 phosphate binding site [ion binding]; other site 1144275007806 putative substrate binding pocket [chemical binding]; other site 1144275007807 dimer interface [polypeptide binding]; other site 1144275007808 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275007809 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275007810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275007811 catalytic residue [active] 1144275007812 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275007813 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1144275007814 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275007815 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1144275007816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275007817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275007818 binding surface 1144275007819 TPR motif; other site 1144275007820 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275007821 Cytochrome C biogenesis protein; Region: CcmH; cl01179 1144275007822 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275007823 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1144275007824 CcmE; Region: CcmE; cl00994 1144275007825 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1144275007826 CcmB protein; Region: CcmB; cl01016 1144275007827 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1144275007828 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275007829 Walker A/P-loop; other site 1144275007830 ATP binding site [chemical binding]; other site 1144275007831 Q-loop/lid; other site 1144275007832 ABC transporter signature motif; other site 1144275007833 Walker B; other site 1144275007834 D-loop; other site 1144275007835 H-loop/switch region; other site 1144275007836 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 1144275007837 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1144275007838 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1144275007839 putative active site [active] 1144275007840 putative metal binding site [ion binding]; other site 1144275007841 MatE; Region: MatE; cl10513 1144275007842 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1144275007843 active site 1144275007844 substrate binding site [chemical binding]; other site 1144275007845 trimer interface [polypeptide binding]; other site 1144275007846 CoA binding site [chemical binding]; other site 1144275007847 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275007848 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1144275007849 putative homodimer interface [polypeptide binding]; other site 1144275007850 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1144275007851 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1144275007852 active site 1144275007853 thiamine phosphate binding site [chemical binding]; other site 1144275007854 pyrophosphate binding site [ion binding]; other site 1144275007855 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1144275007856 ThiS interaction site; other site 1144275007857 putative active site [active] 1144275007858 tetramer interface [polypeptide binding]; other site 1144275007859 Ubiquitin-like proteins; Region: UBQ; cl00155 1144275007860 charged pocket; other site 1144275007861 hydrophobic patch; other site 1144275007862 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275007863 active site 1144275007864 ATP binding site [chemical binding]; other site 1144275007865 substrate binding site [chemical binding]; other site 1144275007866 activation loop (A-loop); other site 1144275007867 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1144275007868 active site 1144275007869 dimer interface [polypeptide binding]; other site 1144275007870 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1144275007871 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1144275007872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275007873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275007874 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1144275007875 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1144275007876 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1144275007877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275007878 active site 1144275007879 motif I; other site 1144275007880 motif II; other site 1144275007881 PUA domain; Region: PUA; cl00607 1144275007882 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1144275007883 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1144275007884 putative RNA binding site [nucleotide binding]; other site 1144275007885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275007886 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1144275007887 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1144275007888 active site 1144275007889 catalytic triad [active] 1144275007890 CAAX protease self-immunity; Region: Abi; cl00558 1144275007891 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 1144275007892 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1144275007893 putative acyl-acceptor binding pocket; other site 1144275007894 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1144275007895 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1144275007896 active site 1144275007897 HIGH motif; other site 1144275007898 KMSK motif region; other site 1144275007899 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1144275007900 tRNA binding surface [nucleotide binding]; other site 1144275007901 anticodon binding site; other site 1144275007902 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1144275007903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275007904 dimer interface [polypeptide binding]; other site 1144275007905 phosphorylation site [posttranslational modification] 1144275007906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275007907 ATP binding site [chemical binding]; other site 1144275007908 Mg2+ binding site [ion binding]; other site 1144275007909 G-X-G motif; other site 1144275007910 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275007911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275007912 active site 1144275007913 phosphorylation site [posttranslational modification] 1144275007914 intermolecular recognition site; other site 1144275007915 dimerization interface [polypeptide binding]; other site 1144275007916 HEAT repeats; Region: HEAT_2; pfam13646 1144275007917 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1144275007918 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275007919 HSP70 interaction site [polypeptide binding]; other site 1144275007920 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1144275007921 Zn binding sites [ion binding]; other site 1144275007922 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1144275007923 dimer interface [polypeptide binding]; other site 1144275007924 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1144275007925 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275007926 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1144275007927 S17 interaction site [polypeptide binding]; other site 1144275007928 S8 interaction site; other site 1144275007929 16S rRNA interaction site [nucleotide binding]; other site 1144275007930 streptomycin interaction site [chemical binding]; other site 1144275007931 23S rRNA interaction site [nucleotide binding]; other site 1144275007932 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1144275007933 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1144275007934 elongation factor G; Reviewed; Region: PRK00007 1144275007935 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1144275007936 G1 box; other site 1144275007937 putative GEF interaction site [polypeptide binding]; other site 1144275007938 GTP/Mg2+ binding site [chemical binding]; other site 1144275007939 Switch I region; other site 1144275007940 G2 box; other site 1144275007941 G3 box; other site 1144275007942 Switch II region; other site 1144275007943 G4 box; other site 1144275007944 G5 box; other site 1144275007945 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1144275007946 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1144275007947 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1144275007948 elongation factor Tu; Reviewed; Region: PRK00049 1144275007949 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1144275007950 G1 box; other site 1144275007951 GEF interaction site [polypeptide binding]; other site 1144275007952 GTP/Mg2+ binding site [chemical binding]; other site 1144275007953 Switch I region; other site 1144275007954 G2 box; other site 1144275007955 G3 box; other site 1144275007956 Switch II region; other site 1144275007957 G4 box; other site 1144275007958 G5 box; other site 1144275007959 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1144275007960 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1144275007961 Antibiotic Binding Site [chemical binding]; other site 1144275007962 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1144275007963 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1144275007964 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1144275007965 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1144275007966 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1144275007967 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1144275007968 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 1144275007969 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1144275007970 putative translocon binding site; other site 1144275007971 protein-rRNA interface [nucleotide binding]; other site 1144275007972 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1144275007973 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1144275007974 G-X-X-G motif; other site 1144275007975 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1144275007976 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1144275007977 23S rRNA interface [nucleotide binding]; other site 1144275007978 5S rRNA interface [nucleotide binding]; other site 1144275007979 putative antibiotic binding site [chemical binding]; other site 1144275007980 L25 interface [polypeptide binding]; other site 1144275007981 L27 interface [polypeptide binding]; other site 1144275007982 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1144275007983 23S rRNA interface [nucleotide binding]; other site 1144275007984 putative translocon interaction site; other site 1144275007985 signal recognition particle (SRP54) interaction site; other site 1144275007986 L23 interface [polypeptide binding]; other site 1144275007987 trigger factor interaction site; other site 1144275007988 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1144275007989 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1144275007990 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1144275007991 KOW motif; Region: KOW; cl00354 1144275007992 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1144275007993 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1144275007994 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1144275007995 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1144275007996 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1144275007997 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1144275007998 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1144275007999 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1144275008000 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1144275008001 5S rRNA interface [nucleotide binding]; other site 1144275008002 L27 interface [polypeptide binding]; other site 1144275008003 23S rRNA interface [nucleotide binding]; other site 1144275008004 L5 interface [polypeptide binding]; other site 1144275008005 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1144275008006 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1144275008007 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1144275008008 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1144275008009 23S rRNA binding site [nucleotide binding]; other site 1144275008010 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1144275008011 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1144275008012 SecY translocase; Region: SecY; pfam00344 1144275008013 adenylate kinase; Reviewed; Region: adk; PRK00279 1144275008014 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1144275008015 AMP-binding site [chemical binding]; other site 1144275008016 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1144275008017 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1144275008018 active site 1144275008019 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1144275008020 rRNA binding site [nucleotide binding]; other site 1144275008021 predicted 30S ribosome binding site; other site 1144275008022 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1144275008023 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1144275008024 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1144275008025 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1144275008026 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1144275008027 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1144275008028 RNA binding surface [nucleotide binding]; other site 1144275008029 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1144275008030 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1144275008031 alphaNTD homodimer interface [polypeptide binding]; other site 1144275008032 alphaNTD - beta interaction site [polypeptide binding]; other site 1144275008033 alphaNTD - beta' interaction site [polypeptide binding]; other site 1144275008034 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1144275008035 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1144275008036 TPR repeat; Region: TPR_11; pfam13414 1144275008037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008038 TPR motif; other site 1144275008039 binding surface 1144275008040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008041 TPR motif; other site 1144275008042 TPR repeat; Region: TPR_11; pfam13414 1144275008043 binding surface 1144275008044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008045 binding surface 1144275008046 TPR motif; other site 1144275008047 TPR repeat; Region: TPR_11; pfam13414 1144275008048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275008049 putative acyl-acceptor binding pocket; other site 1144275008050 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1144275008051 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1144275008052 Substrate-binding site [chemical binding]; other site 1144275008053 Substrate specificity [chemical binding]; other site 1144275008054 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1144275008055 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275008056 phosphopeptide binding site; other site 1144275008057 GAF domain; Region: GAF; cl15785 1144275008058 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275008059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008060 Helix-turn-helix domains; Region: HTH; cl00088 1144275008061 EamA-like transporter family; Region: EamA; cl01037 1144275008062 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1144275008063 EamA-like transporter family; Region: EamA; cl01037 1144275008064 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 1144275008065 GAF domain; Region: GAF; cl15785 1144275008066 NAD-dependent deacetylase; Provisional; Region: PRK00481 1144275008067 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1144275008068 NAD+ binding site [chemical binding]; other site 1144275008069 substrate binding site [chemical binding]; other site 1144275008070 Zn binding site [ion binding]; other site 1144275008071 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1144275008072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275008073 ATP binding site [chemical binding]; other site 1144275008074 putative Mg++ binding site [ion binding]; other site 1144275008075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275008076 nucleotide binding region [chemical binding]; other site 1144275008077 ATP-binding site [chemical binding]; other site 1144275008078 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1144275008079 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1144275008080 ligand binding site [chemical binding]; other site 1144275008081 Protein of unknown function (DUF504); Region: DUF504; cl00661 1144275008082 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 1144275008083 putative catalytic site [active] 1144275008084 putative metal binding site [ion binding]; other site 1144275008085 putative phosphate binding site [ion binding]; other site 1144275008086 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1144275008087 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1144275008088 Poly(A) polymerase central domain; Region: PAP_central; pfam04928 1144275008089 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 1144275008090 active site 1144275008091 putative primer-binding pocket; other site 1144275008092 metal binding triad [ion binding]; metal-binding site 1144275008093 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275008094 active site 1144275008095 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275008096 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275008097 active site 1144275008098 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1144275008099 Helix-turn-helix domains; Region: HTH; cl00088 1144275008100 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1144275008101 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275008102 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275008103 active site 1144275008104 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275008105 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1144275008106 NAD(P) binding site [chemical binding]; other site 1144275008107 substrate binding site [chemical binding]; other site 1144275008108 homotetramer interface [polypeptide binding]; other site 1144275008109 active site 1144275008110 homodimer interface [polypeptide binding]; other site 1144275008111 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1144275008112 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275008113 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275008114 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1144275008115 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1144275008116 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275008117 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1144275008118 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1144275008119 carboxyltransferase (CT) interaction site; other site 1144275008120 biotinylation site [posttranslational modification]; other site 1144275008121 enoyl-CoA hydratase; Provisional; Region: PRK07827 1144275008122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275008123 substrate binding site [chemical binding]; other site 1144275008124 oxyanion hole (OAH) forming residues; other site 1144275008125 trimer interface [polypeptide binding]; other site 1144275008126 acyl-CoA synthetase; Validated; Region: PRK08316 1144275008127 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275008128 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275008129 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1144275008130 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1144275008131 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 1144275008132 Gas vesicle protein G; Region: GvpG; pfam05120 1144275008133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008134 ATP binding site [chemical binding]; other site 1144275008135 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1144275008136 putative Mg++ binding site [ion binding]; other site 1144275008137 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008138 nucleotide binding region [chemical binding]; other site 1144275008139 haloalkane dehalogenase; Provisional; Region: PRK03592 1144275008140 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275008141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275008142 Helix-turn-helix domains; Region: HTH; cl00088 1144275008143 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1144275008144 substrate binding pocket [chemical binding]; other site 1144275008145 dimerization interface [polypeptide binding]; other site 1144275008146 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 1144275008147 putative hydrophobic ligand binding site [chemical binding]; other site 1144275008148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275008149 dimerization interface [polypeptide binding]; other site 1144275008150 putative DNA binding site [nucleotide binding]; other site 1144275008151 putative Zn2+ binding site [ion binding]; other site 1144275008152 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1144275008153 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275008154 putative metal binding site [ion binding]; other site 1144275008155 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1144275008156 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1144275008157 Repair protein; Region: Repair_PSII; cl01535 1144275008158 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275008159 Protein of unknown function (DUF419); Region: DUF419; cl15265 1144275008160 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1144275008161 putative hydrophobic ligand binding site [chemical binding]; other site 1144275008162 HYR domain; Region: HYR; pfam02494 1144275008163 HYR domain; Region: HYR; pfam02494 1144275008164 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 1144275008165 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1144275008166 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1144275008167 active site 1144275008168 TDP-binding site; other site 1144275008169 acceptor substrate-binding pocket; other site 1144275008170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275008171 Helix-turn-helix domains; Region: HTH; cl00088 1144275008172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1144275008173 Histidine kinase; Region: HisKA_3; pfam07730 1144275008174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1144275008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008176 active site 1144275008177 phosphorylation site [posttranslational modification] 1144275008178 intermolecular recognition site; other site 1144275008179 dimerization interface [polypeptide binding]; other site 1144275008180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275008181 DNA binding residues [nucleotide binding] 1144275008182 dimerization interface [polypeptide binding]; other site 1144275008183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275008184 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275008185 Helix-turn-helix domains; Region: HTH; cl00088 1144275008186 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275008187 putative effector binding pocket; other site 1144275008188 dimerization interface [polypeptide binding]; other site 1144275008189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275008190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275008191 S-adenosylmethionine binding site [chemical binding]; other site 1144275008192 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 1144275008193 Active_site [active] 1144275008194 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1144275008195 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1144275008196 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275008197 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 1144275008198 putative substrate binding site [chemical binding]; other site 1144275008199 active site 1144275008200 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1144275008201 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1144275008202 NADP binding site [chemical binding]; other site 1144275008203 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1144275008204 heme binding pocket [chemical binding]; other site 1144275008205 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275008206 L-type amino acid transporter; Region: 2A0308; TIGR00911 1144275008207 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1144275008208 homotrimer interaction site [polypeptide binding]; other site 1144275008209 putative active site [active] 1144275008210 LysR family transcriptional regulator; Provisional; Region: PRK14997 1144275008211 Helix-turn-helix domains; Region: HTH; cl00088 1144275008212 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275008213 putative effector binding pocket; other site 1144275008214 dimerization interface [polypeptide binding]; other site 1144275008215 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1144275008216 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1144275008217 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1144275008218 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1144275008219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275008221 DNA binding residues [nucleotide binding] 1144275008222 dimerization interface [polypeptide binding]; other site 1144275008223 SpoVR like protein; Region: SpoVR; pfam04293 1144275008224 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1144275008225 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275008226 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275008227 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275008228 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275008229 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275008230 Cupin domain; Region: Cupin_2; cl09118 1144275008231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275008232 Helix-turn-helix domain; Region: HTH_18; pfam12833 1144275008233 EamA-like transporter family; Region: EamA; cl01037 1144275008234 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275008235 structural tetrad; other site 1144275008236 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1144275008237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1144275008238 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1144275008239 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1144275008240 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1144275008241 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1144275008242 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1144275008243 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1144275008244 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1144275008245 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1144275008246 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1144275008247 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275008248 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1144275008249 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1144275008250 HYR domain; Region: HYR; pfam02494 1144275008251 HYR domain; Region: HYR; pfam02494 1144275008252 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1144275008253 TIGR02452 family protein; Region: TIGR02452 1144275008254 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1144275008255 putative lyase; Provisional; Region: PRK09687 1144275008256 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1144275008257 active site 1144275008258 zinc binding site [ion binding]; other site 1144275008259 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275008260 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1144275008261 putative C-terminal domain interface [polypeptide binding]; other site 1144275008262 putative GSH binding site (G-site) [chemical binding]; other site 1144275008263 putative dimer interface [polypeptide binding]; other site 1144275008264 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275008265 N-terminal domain interface [polypeptide binding]; other site 1144275008266 dimer interface [polypeptide binding]; other site 1144275008267 substrate binding pocket (H-site) [chemical binding]; other site 1144275008268 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275008269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275008270 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1144275008271 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1144275008272 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275008273 LCCL domain; Region: LCCL; cl02694 1144275008274 LCCL domain; Region: LCCL; cl02694 1144275008275 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1144275008276 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 1144275008277 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275008278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275008279 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1144275008280 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1144275008281 inhibitor-cofactor binding pocket; inhibition site 1144275008282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275008283 catalytic residue [active] 1144275008284 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1144275008285 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1144275008286 NAD binding site [chemical binding]; other site 1144275008287 catalytic Zn binding site [ion binding]; other site 1144275008288 structural Zn binding site [ion binding]; other site 1144275008289 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1144275008290 Clp amino terminal domain; Region: Clp_N; pfam02861 1144275008291 Clp amino terminal domain; Region: Clp_N; pfam02861 1144275008292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275008293 Walker A motif; other site 1144275008294 ATP binding site [chemical binding]; other site 1144275008295 Walker B motif; other site 1144275008296 arginine finger; other site 1144275008297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275008298 Walker A motif; other site 1144275008299 ATP binding site [chemical binding]; other site 1144275008300 Walker B motif; other site 1144275008301 arginine finger; other site 1144275008302 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275008303 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275008304 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008305 active site 1144275008306 ATP binding site [chemical binding]; other site 1144275008307 substrate binding site [chemical binding]; other site 1144275008308 activation loop (A-loop); other site 1144275008309 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1144275008310 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275008311 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275008312 ABC transporter; Region: ABC_tran_2; pfam12848 1144275008313 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275008314 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 1144275008315 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 1144275008316 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1144275008317 Peptidase M35 family; Region: M35_like; cl03449 1144275008318 active site 1144275008319 Zn binding site [ion binding]; other site 1144275008320 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1144275008321 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1144275008322 GAF domain; Region: GAF_2; pfam13185 1144275008323 GAF domain; Region: GAF; cl15785 1144275008324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275008325 phosphorylation site [posttranslational modification] 1144275008326 dimer interface [polypeptide binding]; other site 1144275008327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275008328 ATP binding site [chemical binding]; other site 1144275008329 Mg2+ binding site [ion binding]; other site 1144275008330 G-X-G motif; other site 1144275008331 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1144275008332 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275008333 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275008334 catalytic residue [active] 1144275008335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275008336 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275008337 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008338 active site 1144275008339 ATP binding site [chemical binding]; other site 1144275008340 substrate binding site [chemical binding]; other site 1144275008341 activation loop (A-loop); other site 1144275008342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1144275008343 active site 1144275008344 metal binding site [ion binding]; metal-binding site 1144275008345 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 1144275008346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275008347 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1144275008348 active site 1144275008349 tyrosine kinase; Provisional; Region: PRK11519 1144275008350 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008351 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1144275008352 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275008353 HSP70 interaction site [polypeptide binding]; other site 1144275008354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275008355 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1144275008356 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1144275008357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275008358 active site 1144275008359 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275008360 HEAT repeats; Region: HEAT_2; pfam13646 1144275008361 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275008362 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275008363 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1144275008364 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1144275008365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275008366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1144275008367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275008368 DNA binding residues [nucleotide binding] 1144275008369 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1144275008370 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1144275008371 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1144275008372 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275008373 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275008374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275008375 Walker A motif; other site 1144275008376 ATP binding site [chemical binding]; other site 1144275008377 Walker B motif; other site 1144275008378 arginine finger; other site 1144275008379 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1144275008380 anti sigma factor interaction site; other site 1144275008381 regulatory phosphorylation site [posttranslational modification]; other site 1144275008382 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275008383 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275008384 catalytic residue [active] 1144275008385 HupE / UreJ protein; Region: HupE_UreJ; cl01011 1144275008386 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1144275008387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1144275008388 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008389 TPR motif; other site 1144275008390 binding surface 1144275008391 tol-pal system protein YbgF; Provisional; Region: PRK10803 1144275008392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008393 binding surface 1144275008394 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275008395 TPR motif; other site 1144275008396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275008397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008398 binding surface 1144275008399 TPR motif; other site 1144275008400 TPR repeat; Region: TPR_11; pfam13414 1144275008401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275008402 binding surface 1144275008403 TPR motif; other site 1144275008404 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275008405 phosphopeptide binding site; other site 1144275008406 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275008407 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275008408 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1144275008409 Helix-turn-helix domain; Region: HTH_18; pfam12833 1144275008410 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1144275008411 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1144275008412 G1 box; other site 1144275008413 putative GEF interaction site [polypeptide binding]; other site 1144275008414 GTP/Mg2+ binding site [chemical binding]; other site 1144275008415 Switch I region; other site 1144275008416 G2 box; other site 1144275008417 G3 box; other site 1144275008418 Switch II region; other site 1144275008419 G4 box; other site 1144275008420 G5 box; other site 1144275008421 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1144275008422 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1144275008423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275008424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275008425 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1144275008426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275008427 Walker A motif; other site 1144275008428 ATP binding site [chemical binding]; other site 1144275008429 Walker B motif; other site 1144275008430 arginine finger; other site 1144275008431 Helix-turn-helix domains; Region: HTH; cl00088 1144275008432 Cation efflux family; Region: Cation_efflux; cl00316 1144275008433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275008434 S-adenosylmethionine binding site [chemical binding]; other site 1144275008435 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1144275008436 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1144275008437 active site 1144275008438 (T/H)XGH motif; other site 1144275008439 aspartate aminotransferase; Provisional; Region: PRK05764 1144275008440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275008441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275008442 homodimer interface [polypeptide binding]; other site 1144275008443 catalytic residue [active] 1144275008444 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008445 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008446 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1144275008447 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1144275008448 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008449 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008450 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008451 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008452 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1144275008453 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1144275008454 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275008455 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1144275008456 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1144275008457 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275008458 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1144275008459 IMP binding site; other site 1144275008460 dimer interface [polypeptide binding]; other site 1144275008461 interdomain contacts; other site 1144275008462 partial ornithine binding site; other site 1144275008463 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275008464 Rhomboid family; Region: Rhomboid; cl11446 1144275008465 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1144275008466 PAS fold; Region: PAS_4; pfam08448 1144275008467 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275008468 putative active site [active] 1144275008469 heme pocket [chemical binding]; other site 1144275008470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275008471 putative active site [active] 1144275008472 PAS fold; Region: PAS_3; pfam08447 1144275008473 heme pocket [chemical binding]; other site 1144275008474 PAS fold; Region: PAS_4; pfam08448 1144275008475 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275008476 PAS fold; Region: PAS_4; pfam08448 1144275008477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275008478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275008479 ATP binding site [chemical binding]; other site 1144275008480 Mg2+ binding site [ion binding]; other site 1144275008481 G-X-G motif; other site 1144275008482 Protein of unknown function (DUF1622); Region: DUF1622; cl01991 1144275008483 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275008484 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1144275008485 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1144275008486 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 1144275008487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1144275008488 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1144275008489 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1144275008490 Baseplate J-like protein; Region: Baseplate_J; cl01294 1144275008491 Baseplate J-like protein; Region: Baseplate_J; cl01294 1144275008492 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275008493 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1144275008494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1144275008495 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 1144275008496 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1144275008497 Substrate binding site [chemical binding]; other site 1144275008498 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1144275008499 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1144275008500 SpaB C-terminal domain; Region: SpaB_C; cl14828 1144275008501 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1144275008502 active site 1144275008503 zinc binding site [ion binding]; other site 1144275008504 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1144275008505 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275008506 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1144275008507 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1144275008508 trimer interface [polypeptide binding]; other site 1144275008509 active site 1144275008510 CoA binding site [chemical binding]; other site 1144275008511 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008512 HEAT repeats; Region: HEAT_2; pfam13646 1144275008513 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275008514 Annexin; Region: Annexin; cl02574 1144275008515 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1144275008516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275008517 Walker A motif; other site 1144275008518 ATP binding site [chemical binding]; other site 1144275008519 Walker B motif; other site 1144275008520 arginine finger; other site 1144275008521 Flavin Reductases; Region: FlaRed; cl00801 1144275008522 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1144275008523 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1144275008524 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1144275008525 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275008526 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008527 active site 1144275008528 ATP binding site [chemical binding]; other site 1144275008529 substrate binding site [chemical binding]; other site 1144275008530 activation loop (A-loop); other site 1144275008531 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1144275008532 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1144275008533 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1144275008534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275008535 DNA binding residues [nucleotide binding] 1144275008536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275008537 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1144275008538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275008539 catalytic residue [active] 1144275008540 Restriction endonuclease; Region: Mrr_cat; cl00516 1144275008541 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008542 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008543 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008544 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008545 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008546 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008547 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008548 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008549 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008550 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008551 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008552 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008553 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008554 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008555 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275008556 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275008557 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275008558 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275008559 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275008560 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275008561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275008562 S-adenosylmethionine binding site [chemical binding]; other site 1144275008563 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1144275008564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275008565 binding surface 1144275008566 TPR motif; other site 1144275008567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008568 binding surface 1144275008569 TPR motif; other site 1144275008570 TPR repeat; Region: TPR_11; pfam13414 1144275008571 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 1144275008572 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008574 active site 1144275008575 phosphorylation site [posttranslational modification] 1144275008576 intermolecular recognition site; other site 1144275008577 dimerization interface [polypeptide binding]; other site 1144275008578 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1144275008579 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1144275008580 ring oligomerisation interface [polypeptide binding]; other site 1144275008581 ATP/Mg binding site [chemical binding]; other site 1144275008582 stacking interactions; other site 1144275008583 hinge regions; other site 1144275008584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275008585 dimer interface [polypeptide binding]; other site 1144275008586 phosphorylation site [posttranslational modification] 1144275008587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275008588 ATP binding site [chemical binding]; other site 1144275008589 Mg2+ binding site [ion binding]; other site 1144275008590 G-X-G motif; other site 1144275008591 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008593 active site 1144275008594 phosphorylation site [posttranslational modification] 1144275008595 intermolecular recognition site; other site 1144275008596 dimerization interface [polypeptide binding]; other site 1144275008597 Uncharacterized conserved protein [Function unknown]; Region: COG3461 1144275008598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008599 active site 1144275008600 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 1144275008601 phosphorylation site [posttranslational modification] 1144275008602 intermolecular recognition site; other site 1144275008603 dimerization interface [polypeptide binding]; other site 1144275008604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275008605 metal binding site [ion binding]; metal-binding site 1144275008606 active site 1144275008607 I-site; other site 1144275008608 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275008609 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275008610 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008612 active site 1144275008613 phosphorylation site [posttranslational modification] 1144275008614 intermolecular recognition site; other site 1144275008615 dimerization interface [polypeptide binding]; other site 1144275008616 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1144275008617 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1144275008618 HIGH motif; other site 1144275008619 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1144275008620 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1144275008621 active site 1144275008622 KMSKS motif; other site 1144275008623 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1144275008624 tRNA binding surface [nucleotide binding]; other site 1144275008625 anticodon binding site; other site 1144275008626 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1144275008627 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1144275008628 nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078 1144275008629 dimerization interface [polypeptide binding]; other site 1144275008630 active site 1144275008631 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1144275008632 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1144275008633 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275008634 active site 1144275008635 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1144275008636 putative active site [active] 1144275008637 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1144275008638 hydrophobic ligand binding site; other site 1144275008639 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1144275008640 enolase; Provisional; Region: eno; PRK00077 1144275008641 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1144275008642 dimer interface [polypeptide binding]; other site 1144275008643 metal binding site [ion binding]; metal-binding site 1144275008644 substrate binding pocket [chemical binding]; other site 1144275008645 Survival protein SurE; Region: SurE; cl00448 1144275008646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275008647 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275008648 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1144275008649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275008650 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1144275008651 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275008652 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275008653 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275008654 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275008655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275008656 NAD(P) binding site [chemical binding]; other site 1144275008657 active site 1144275008658 TolB amino-terminal domain; Region: TolB_N; cl00639 1144275008659 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275008660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008661 binding surface 1144275008662 TPR motif; other site 1144275008663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275008664 binding surface 1144275008665 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275008666 TPR motif; other site 1144275008667 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275008668 LexA repressor; Validated; Region: PRK00215 1144275008669 Helix-turn-helix domains; Region: HTH; cl00088 1144275008670 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1144275008671 Catalytic site [active] 1144275008672 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008674 active site 1144275008675 phosphorylation site [posttranslational modification] 1144275008676 intermolecular recognition site; other site 1144275008677 dimerization interface [polypeptide binding]; other site 1144275008678 GAF domain; Region: GAF_2; pfam13185 1144275008679 GAF domain; Region: GAF; cl15785 1144275008680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1144275008681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275008682 dimer interface [polypeptide binding]; other site 1144275008683 phosphorylation site [posttranslational modification] 1144275008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275008685 ATP binding site [chemical binding]; other site 1144275008686 G-X-G motif; other site 1144275008687 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008689 active site 1144275008690 phosphorylation site [posttranslational modification] 1144275008691 intermolecular recognition site; other site 1144275008692 dimerization interface [polypeptide binding]; other site 1144275008693 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008695 active site 1144275008696 phosphorylation site [posttranslational modification] 1144275008697 intermolecular recognition site; other site 1144275008698 dimerization interface [polypeptide binding]; other site 1144275008699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275008700 metal binding site [ion binding]; metal-binding site 1144275008701 active site 1144275008702 I-site; other site 1144275008703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275008704 phosphorylation site [posttranslational modification] 1144275008705 dimer interface [polypeptide binding]; other site 1144275008706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275008707 ATP binding site [chemical binding]; other site 1144275008708 Mg2+ binding site [ion binding]; other site 1144275008709 G-X-G motif; other site 1144275008710 Ribosomal protein L5 [Translation, ribosomal structure and biogenesis]; Region: RplE; COG0094 1144275008711 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275008712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275008713 active site 1144275008714 phosphorylation site [posttranslational modification] 1144275008715 intermolecular recognition site; other site 1144275008716 dimerization interface [polypeptide binding]; other site 1144275008717 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1144275008718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275008719 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1144275008720 active site 1144275008721 metal binding site [ion binding]; metal-binding site 1144275008722 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275008723 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275008724 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1144275008725 cleavage site 1144275008726 active site 1144275008727 substrate binding sites [chemical binding]; other site 1144275008728 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275008729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008730 active site 1144275008731 ATP binding site [chemical binding]; other site 1144275008732 substrate binding site [chemical binding]; other site 1144275008733 activation loop (A-loop); other site 1144275008734 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008735 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1144275008736 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1144275008737 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275008738 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275008739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275008740 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1144275008741 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1144275008742 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 1144275008743 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 1144275008744 active site 1144275008745 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275008746 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275008747 putative sugar binding sites [chemical binding]; other site 1144275008748 Q-X-W motif; other site 1144275008749 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275008750 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275008751 putative sugar binding sites [chemical binding]; other site 1144275008752 Q-X-W motif; other site 1144275008753 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1144275008754 putative hydrophobic ligand binding site [chemical binding]; other site 1144275008755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275008756 dimerization interface [polypeptide binding]; other site 1144275008757 putative DNA binding site [nucleotide binding]; other site 1144275008758 putative Zn2+ binding site [ion binding]; other site 1144275008759 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275008760 ligand binding site [chemical binding]; other site 1144275008761 O-methyltransferase; Region: Methyltransf_2; pfam00891 1144275008762 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1144275008763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275008764 S-adenosylmethionine binding site [chemical binding]; other site 1144275008765 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 1144275008766 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1144275008767 Family description; Region: UvrD_C_2; cl15862 1144275008768 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275008769 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275008770 active site 1144275008771 ATP binding site [chemical binding]; other site 1144275008772 substrate binding site [chemical binding]; other site 1144275008773 activation loop (A-loop); other site 1144275008774 Protein kinase domain; Region: Pkinase; pfam00069 1144275008775 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008776 active site 1144275008777 ATP binding site [chemical binding]; other site 1144275008778 substrate binding site [chemical binding]; other site 1144275008779 activation loop (A-loop); other site 1144275008780 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275008781 enoyl-CoA hydratase; Provisional; Region: PRK06142 1144275008782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275008783 substrate binding site [chemical binding]; other site 1144275008784 oxyanion hole (OAH) forming residues; other site 1144275008785 trimer interface [polypeptide binding]; other site 1144275008786 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1144275008787 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1144275008788 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275008789 O-methyltransferase; Region: Methyltransf_2; pfam00891 1144275008790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275008791 putative DNA binding site [nucleotide binding]; other site 1144275008792 dimerization interface [polypeptide binding]; other site 1144275008793 putative Zn2+ binding site [ion binding]; other site 1144275008794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275008795 S-adenosylmethionine binding site [chemical binding]; other site 1144275008796 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275008797 putative catalytic site [active] 1144275008798 putative metal binding site [ion binding]; other site 1144275008799 putative phosphate binding site [ion binding]; other site 1144275008800 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1144275008801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1144275008802 active site 1144275008803 DNA binding site [nucleotide binding] 1144275008804 Int/Topo IB signature motif; other site 1144275008805 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275008806 metal binding site [ion binding]; metal-binding site 1144275008807 Helix-turn-helix domains; Region: HTH; cl00088 1144275008808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1144275008809 dimerization interface [polypeptide binding]; other site 1144275008810 glutathionine S-transferase; Provisional; Region: PRK10542 1144275008811 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1144275008812 C-terminal domain interface [polypeptide binding]; other site 1144275008813 GSH binding site (G-site) [chemical binding]; other site 1144275008814 dimer interface [polypeptide binding]; other site 1144275008815 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1144275008816 dimer interface [polypeptide binding]; other site 1144275008817 N-terminal domain interface [polypeptide binding]; other site 1144275008818 substrate binding pocket (H-site) [chemical binding]; other site 1144275008819 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1144275008820 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275008821 putative catalytic site [active] 1144275008822 putative metal binding site [ion binding]; other site 1144275008823 putative phosphate binding site [ion binding]; other site 1144275008824 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1144275008825 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275008826 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1144275008827 PA14 domain; Region: PA14; cl08459 1144275008828 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1144275008829 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1144275008830 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1144275008831 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1144275008832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275008833 NAD(P) binding site [chemical binding]; other site 1144275008834 active site 1144275008835 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275008836 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008837 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1144275008838 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275008839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275008840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008841 Walker A/P-loop; other site 1144275008842 ATP binding site [chemical binding]; other site 1144275008843 Q-loop/lid; other site 1144275008844 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1144275008845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275008846 Walker A/P-loop; other site 1144275008847 ATP binding site [chemical binding]; other site 1144275008848 Q-loop/lid; other site 1144275008849 ABC transporter signature motif; other site 1144275008850 Walker B; other site 1144275008851 D-loop; other site 1144275008852 H-loop/switch region; other site 1144275008853 DinB superfamily; Region: DinB_2; pfam12867 1144275008854 Condensation domain; Region: Condensation; pfam00668 1144275008855 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275008856 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1144275008857 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275008858 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275008859 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008860 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275008861 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275008862 active site 1144275008863 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275008864 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275008865 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1144275008866 putative NADP binding site [chemical binding]; other site 1144275008867 active site 1144275008868 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008869 Thioesterase domain; Region: Thioesterase; pfam00975 1144275008870 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275008871 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275008872 active site 1144275008873 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1144275008874 putative NADP binding site [chemical binding]; other site 1144275008875 active site 1144275008876 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008877 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275008878 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275008879 active site 1144275008880 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1144275008881 putative NADP binding site [chemical binding]; other site 1144275008882 active site 1144275008883 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008884 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275008885 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275008886 active site 1144275008887 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275008888 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275008889 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1144275008890 putative NADP binding site [chemical binding]; other site 1144275008891 active site 1144275008892 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008893 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1144275008894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275008895 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275008896 MepB protein; Region: MepB; cl01985 1144275008897 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275008898 putative catalytic site [active] 1144275008899 putative metal binding site [ion binding]; other site 1144275008900 putative phosphate binding site [ion binding]; other site 1144275008901 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275008902 putative catalytic site [active] 1144275008903 putative phosphate binding site [ion binding]; other site 1144275008904 putative metal binding site [ion binding]; other site 1144275008905 Bacterial SH3 domain; Region: SH3_3; cl02551 1144275008906 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275008907 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275008908 putative sugar binding sites [chemical binding]; other site 1144275008909 Q-X-W motif; other site 1144275008910 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275008911 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1144275008912 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275008913 MG2 domain; Region: A2M_N; pfam01835 1144275008914 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275008915 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1144275008916 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1144275008917 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1144275008918 surface patch; other site 1144275008919 thioester region; other site 1144275008920 A-macroglobulin complement component; Region: A2M_comp; pfam07678 1144275008921 specificity defining residues; other site 1144275008922 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275008923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275008924 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275008925 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1144275008926 hypothetical protein; Provisional; Region: PRK08317 1144275008927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275008928 S-adenosylmethionine binding site [chemical binding]; other site 1144275008929 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1144275008930 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1144275008931 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 1144275008932 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1144275008933 active site 1144275008934 catalytic site [active] 1144275008935 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1144275008936 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1144275008937 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008938 active site 1144275008939 ATP binding site [chemical binding]; other site 1144275008940 substrate binding site [chemical binding]; other site 1144275008941 activation loop (A-loop); other site 1144275008942 potential frameshift: common BLAST hit: gi|338531514|ref|YP_004664848.1| serine/threonine protein kinase 1144275008943 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275008944 active site 1144275008945 substrate binding site [chemical binding]; other site 1144275008946 activation loop (A-loop); other site 1144275008947 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275008948 Phage capsid family; Region: Phage_capsid; pfam05065 1144275008949 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1144275008950 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275008951 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275008952 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275008953 Rdx family; Region: Rdx; cl01407 1144275008954 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008955 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008956 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275008957 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1144275008958 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1144275008959 putative diguanylate cyclase; Provisional; Region: PRK09776 1144275008960 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275008961 GAF domain; Region: GAF_2; pfam13185 1144275008962 GAF domain; Region: GAF; cl15785 1144275008963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275008964 dimer interface [polypeptide binding]; other site 1144275008965 phosphorylation site [posttranslational modification] 1144275008966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275008967 ATP binding site [chemical binding]; other site 1144275008968 Mg2+ binding site [ion binding]; other site 1144275008969 G-X-G motif; other site 1144275008970 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275008971 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275008972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275008973 DNA binding residues [nucleotide binding] 1144275008974 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275008975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275008976 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1144275008977 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1144275008978 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275008979 catalytic residue [active] 1144275008980 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275008981 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275008982 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275008983 Protein of unknown function, DUF488; Region: DUF488; cl01246 1144275008984 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1144275008985 Catalytic site [active] 1144275008986 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1144275008987 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1144275008988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275008989 dimerization interface [polypeptide binding]; other site 1144275008990 putative DNA binding site [nucleotide binding]; other site 1144275008991 putative Zn2+ binding site [ion binding]; other site 1144275008992 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275008993 hydrophobic ligand binding site; other site 1144275008994 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1144275008995 Cytochrome c; Region: Cytochrom_C; cl11414 1144275008996 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1144275008997 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 1144275008998 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275008999 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 1144275009000 hypothetical protein; Provisional; Region: PRK11770 1144275009001 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1144275009002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275009003 active site 1144275009004 ATP binding site [chemical binding]; other site 1144275009005 substrate binding site [chemical binding]; other site 1144275009006 activation loop (A-loop); other site 1144275009007 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009008 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1144275009009 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275009010 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275009011 protein binding site [polypeptide binding]; other site 1144275009012 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275009013 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275009014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009015 active site 1144275009016 phosphorylation site [posttranslational modification] 1144275009017 intermolecular recognition site; other site 1144275009018 dimerization interface [polypeptide binding]; other site 1144275009019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275009020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009021 ATP binding site [chemical binding]; other site 1144275009022 Mg2+ binding site [ion binding]; other site 1144275009023 G-X-G motif; other site 1144275009024 Arginase family; Region: Arginase; cl00306 1144275009025 Protein of unknown function (DUF419); Region: DUF419; cl15265 1144275009026 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1144275009027 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1144275009028 NAD(P) binding site [chemical binding]; other site 1144275009029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1144275009030 Divalent cation transporter; Region: MgtE; cl00786 1144275009031 Domain of unknown function (DUF329); Region: DUF329; cl01144 1144275009032 Predicted integral membrane protein [Function unknown]; Region: COG0392 1144275009033 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1144275009034 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1144275009035 Predicted membrane protein [Function unknown]; Region: COG2119 1144275009036 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1144275009037 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1144275009038 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1144275009039 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1144275009040 putative NAD(P) binding site [chemical binding]; other site 1144275009041 putative substrate binding site [chemical binding]; other site 1144275009042 catalytic Zn binding site [ion binding]; other site 1144275009043 structural Zn binding site [ion binding]; other site 1144275009044 dimer interface [polypeptide binding]; other site 1144275009045 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1144275009046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275009047 S-adenosylmethionine binding site [chemical binding]; other site 1144275009048 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1144275009049 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1144275009050 tetramer interface [polypeptide binding]; other site 1144275009051 active site 1144275009052 Mg2+/Mn2+ binding site [ion binding]; other site 1144275009053 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1144275009054 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1144275009055 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1144275009056 DNA binding site [nucleotide binding] 1144275009057 active site 1144275009058 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1144275009059 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1144275009060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275009061 AlkA N-terminal domain; Region: AlkA_N; cl05528 1144275009062 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1144275009063 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1144275009064 minor groove reading motif; other site 1144275009065 helix-hairpin-helix signature motif; other site 1144275009066 substrate binding pocket [chemical binding]; other site 1144275009067 active site 1144275009068 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1144275009069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275009070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275009071 active site 1144275009072 ATP binding site [chemical binding]; other site 1144275009073 substrate binding site [chemical binding]; other site 1144275009074 activation loop (A-loop); other site 1144275009075 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1144275009076 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275009077 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1144275009078 putative active site [active] 1144275009079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275009080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009081 Walker A/P-loop; other site 1144275009082 ATP binding site [chemical binding]; other site 1144275009083 Q-loop/lid; other site 1144275009084 ABC transporter signature motif; other site 1144275009085 Walker B; other site 1144275009086 D-loop; other site 1144275009087 H-loop/switch region; other site 1144275009088 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1144275009089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009090 Walker A/P-loop; other site 1144275009091 ATP binding site [chemical binding]; other site 1144275009092 Q-loop/lid; other site 1144275009093 ABC transporter signature motif; other site 1144275009094 Walker B; other site 1144275009095 D-loop; other site 1144275009096 H-loop/switch region; other site 1144275009097 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275009098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275009099 active site 1144275009100 substrate binding site [chemical binding]; other site 1144275009101 ATP binding site [chemical binding]; other site 1144275009102 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1144275009103 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1144275009104 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275009105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009106 dimer interface [polypeptide binding]; other site 1144275009107 phosphorylation site [posttranslational modification] 1144275009108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009109 ATP binding site [chemical binding]; other site 1144275009110 Mg2+ binding site [ion binding]; other site 1144275009111 G-X-G motif; other site 1144275009112 putative acetyltransferase; Provisional; Region: PRK03624 1144275009113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275009114 Coenzyme A binding pocket [chemical binding]; other site 1144275009115 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1144275009116 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275009117 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1144275009118 Dienelactone hydrolase family; Region: DLH; pfam01738 1144275009119 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275009120 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275009121 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275009122 active site 1144275009123 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1144275009124 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275009125 phosphopeptide binding site; other site 1144275009126 Protein phosphatase 2C; Region: PP2C; pfam00481 1144275009127 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1144275009128 active site 1144275009129 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275009130 ligand binding site [chemical binding]; other site 1144275009131 flexible hinge region; other site 1144275009132 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009133 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009134 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009135 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009136 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009137 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009138 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1144275009139 Flavoprotein; Region: Flavoprotein; cl08021 1144275009140 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1144275009141 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275009142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275009143 Helix-turn-helix domains; Region: HTH; cl00088 1144275009144 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1144275009145 substrate binding pocket [chemical binding]; other site 1144275009146 dimerization interface [polypeptide binding]; other site 1144275009147 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1144275009148 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275009149 NAD(P) binding site [chemical binding]; other site 1144275009150 active site 1144275009151 Helix-turn-helix domains; Region: HTH; cl00088 1144275009152 LysR family transcriptional regulator; Provisional; Region: PRK14997 1144275009153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275009154 dimerization interface [polypeptide binding]; other site 1144275009155 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1144275009156 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275009157 metal binding site [ion binding]; metal-binding site 1144275009158 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1144275009159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275009160 non-specific DNA binding site [nucleotide binding]; other site 1144275009161 salt bridge; other site 1144275009162 sequence-specific DNA binding site [nucleotide binding]; other site 1144275009163 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1144275009164 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1144275009165 Fe-S cluster binding site [ion binding]; other site 1144275009166 active site 1144275009167 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275009168 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1144275009169 NAD(P) binding site [chemical binding]; other site 1144275009170 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1144275009171 Interdomain contacts; other site 1144275009172 Cytokine receptor motif; other site 1144275009173 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275009174 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1144275009175 Glyco_18 domain; Region: Glyco_18; smart00636 1144275009176 active site 1144275009177 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1144275009178 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1144275009179 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1144275009180 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1144275009181 tetramer interface [polypeptide binding]; other site 1144275009182 heme binding pocket [chemical binding]; other site 1144275009183 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1144275009184 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1144275009185 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 1144275009186 B12 binding site [chemical binding]; other site 1144275009187 cobalt ligand [ion binding]; other site 1144275009188 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1144275009189 active site 2 [active] 1144275009190 active site 1 [active] 1144275009191 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1144275009192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009193 hypothetical protein; Provisional; Region: PRK08244 1144275009194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009195 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1144275009196 Helix-turn-helix domains; Region: HTH; cl00088 1144275009197 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1144275009198 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275009199 classical (c) SDRs; Region: SDR_c; cd05233 1144275009200 NAD(P) binding site [chemical binding]; other site 1144275009201 active site 1144275009202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275009203 S-adenosylmethionine binding site [chemical binding]; other site 1144275009204 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275009205 Protein of unknown function, DUF399; Region: DUF399; cl01139 1144275009206 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1144275009207 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275009208 N-terminal plug; other site 1144275009209 ligand-binding site [chemical binding]; other site 1144275009210 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275009211 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1144275009212 Ligand Binding Site [chemical binding]; other site 1144275009213 B3/4 domain; Region: B3_4; cl11458 1144275009214 FtsH Extracellular; Region: FtsH_ext; pfam06480 1144275009215 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1144275009216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009218 Walker A motif; other site 1144275009219 ATP binding site [chemical binding]; other site 1144275009220 Walker B motif; other site 1144275009221 arginine finger; other site 1144275009222 Peptidase family M41; Region: Peptidase_M41; pfam01434 1144275009223 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1144275009224 dihydropteroate synthase; Region: DHPS; TIGR01496 1144275009225 substrate binding pocket [chemical binding]; other site 1144275009226 dimer interface [polypeptide binding]; other site 1144275009227 inhibitor binding site; inhibition site 1144275009228 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1144275009229 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1144275009230 active site 1144275009231 substrate binding site [chemical binding]; other site 1144275009232 metal binding site [ion binding]; metal-binding site 1144275009233 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 1144275009234 active site 1144275009235 hydrophilic channel; other site 1144275009236 dimerization interface [polypeptide binding]; other site 1144275009237 catalytic residues [active] 1144275009238 active site lid [active] 1144275009239 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1144275009240 putative carbohydrate kinase; Provisional; Region: PRK10565 1144275009241 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1144275009242 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1144275009243 putative substrate binding site [chemical binding]; other site 1144275009244 putative ATP binding site [chemical binding]; other site 1144275009245 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1144275009246 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1144275009247 putative dimer interface [polypeptide binding]; other site 1144275009248 putative active site [active] 1144275009249 imidazolonepropionase; Validated; Region: PRK09356 1144275009250 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1144275009251 active site 1144275009252 urocanate hydratase; Provisional; Region: PRK05414 1144275009253 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1144275009254 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1144275009255 putative molybdopterin cofactor binding site [chemical binding]; other site 1144275009256 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1144275009257 putative molybdopterin cofactor binding site; other site 1144275009258 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275009259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009260 Walker A motif; other site 1144275009261 ATP binding site [chemical binding]; other site 1144275009262 Walker B motif; other site 1144275009263 arginine finger; other site 1144275009264 enoyl-CoA hydratase; Region: PLN02864 1144275009265 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275009266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275009267 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1144275009268 active site 1144275009269 8-oxo-dGMP binding site [chemical binding]; other site 1144275009270 nudix motif; other site 1144275009271 metal binding site [ion binding]; metal-binding site 1144275009272 FtsH Extracellular; Region: FtsH_ext; pfam06480 1144275009273 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1144275009274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009275 Walker A motif; other site 1144275009276 ATP binding site [chemical binding]; other site 1144275009277 Walker B motif; other site 1144275009278 arginine finger; other site 1144275009279 Peptidase family M41; Region: Peptidase_M41; pfam01434 1144275009280 anthranilate synthase component I; Provisional; Region: PRK13572 1144275009281 heat shock protein GrpE; Provisional; Region: PRK14140 1144275009282 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1144275009283 dimer interface [polypeptide binding]; other site 1144275009284 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1144275009285 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1144275009286 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275009287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275009288 protein binding site [polypeptide binding]; other site 1144275009289 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275009290 protein binding site [polypeptide binding]; other site 1144275009291 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1144275009292 PilZ domain; Region: PilZ; cl01260 1144275009293 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1144275009294 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1144275009295 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1144275009296 NAD(P) binding site [chemical binding]; other site 1144275009297 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 1144275009298 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1144275009299 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1144275009300 FAD binding pocket [chemical binding]; other site 1144275009301 FAD binding motif [chemical binding]; other site 1144275009302 phosphate binding motif [ion binding]; other site 1144275009303 beta-alpha-beta structure motif; other site 1144275009304 NAD binding pocket [chemical binding]; other site 1144275009305 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1144275009306 active site 1 [active] 1144275009307 dimer interface [polypeptide binding]; other site 1144275009308 hexamer interface [polypeptide binding]; other site 1144275009309 active site 2 [active] 1144275009310 Cupin domain; Region: Cupin_2; cl09118 1144275009311 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1144275009312 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1144275009313 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1144275009314 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1144275009315 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 1144275009316 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1144275009317 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275009318 ligand binding site [chemical binding]; other site 1144275009319 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275009320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009321 active site 1144275009322 phosphorylation site [posttranslational modification] 1144275009323 intermolecular recognition site; other site 1144275009324 dimerization interface [polypeptide binding]; other site 1144275009325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009326 Walker A motif; other site 1144275009327 ATP binding site [chemical binding]; other site 1144275009328 Walker B motif; other site 1144275009329 arginine finger; other site 1144275009330 Helix-turn-helix domains; Region: HTH; cl00088 1144275009331 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275009332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009333 phosphorylation site [posttranslational modification] 1144275009334 dimer interface [polypeptide binding]; other site 1144275009335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009336 ATP binding site [chemical binding]; other site 1144275009337 G-X-G motif; other site 1144275009338 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1144275009339 catalytic residues [active] 1144275009340 dimer interface [polypeptide binding]; other site 1144275009341 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275009342 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1144275009343 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1144275009344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009345 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1144275009346 active site clefts [active] 1144275009347 zinc binding site [ion binding]; other site 1144275009348 dimer interface [polypeptide binding]; other site 1144275009349 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1144275009350 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1144275009351 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1144275009352 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1144275009353 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275009354 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275009355 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275009356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275009357 Coenzyme A binding pocket [chemical binding]; other site 1144275009358 peptide synthase; Provisional; Region: PRK12467 1144275009359 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009360 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009361 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009363 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009364 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009365 peptide synthase; Provisional; Region: PRK12316 1144275009366 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009367 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009368 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009369 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009370 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275009371 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009372 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009373 acyl-CoA synthetase; Validated; Region: PRK08308 1144275009374 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009375 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275009376 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275009377 active site 1144275009378 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275009379 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275009380 peptide synthase; Provisional; Region: PRK12467 1144275009381 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009382 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009383 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009384 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1144275009385 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275009386 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009387 peptide synthase; Provisional; Region: PRK12467 1144275009388 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009389 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009390 peptide synthase; Provisional; Region: PRK12316 1144275009391 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009392 peptide synthase; Provisional; Region: PRK12467 1144275009393 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009394 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009395 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009396 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009397 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275009398 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009399 peptide synthase; Provisional; Region: PRK12316 1144275009400 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275009401 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275009402 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275009403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1144275009404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275009405 Coenzyme A binding pocket [chemical binding]; other site 1144275009406 putative oxidoreductase; Provisional; Region: PRK11579 1144275009407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1144275009409 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275009410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275009411 DNA-binding site [nucleotide binding]; DNA binding site 1144275009412 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1144275009413 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 1144275009414 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275009415 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275009416 dinuclear metal binding motif [ion binding]; other site 1144275009417 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1144275009418 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1144275009419 dimer interface [polypeptide binding]; other site 1144275009420 active site 1144275009421 Chorismate mutase type II; Region: CM_2; cl00693 1144275009422 putative alcohol dehydrogenase; Provisional; Region: PRK13771 1144275009423 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1144275009424 NAD(P) binding site [chemical binding]; other site 1144275009425 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1144275009426 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1144275009427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275009428 Helix-turn-helix domains; Region: HTH; cl00088 1144275009429 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275009430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275009431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009432 dimer interface [polypeptide binding]; other site 1144275009433 phosphorylation site [posttranslational modification] 1144275009434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009435 ATP binding site [chemical binding]; other site 1144275009436 G-X-G motif; other site 1144275009437 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275009438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009439 active site 1144275009440 phosphorylation site [posttranslational modification] 1144275009441 intermolecular recognition site; other site 1144275009442 dimerization interface [polypeptide binding]; other site 1144275009443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009444 Walker A motif; other site 1144275009445 ATP binding site [chemical binding]; other site 1144275009446 Walker B motif; other site 1144275009447 arginine finger; other site 1144275009448 Helix-turn-helix domains; Region: HTH; cl00088 1144275009449 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1144275009450 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009452 active site 1144275009453 phosphorylation site [posttranslational modification] 1144275009454 intermolecular recognition site; other site 1144275009455 dimerization interface [polypeptide binding]; other site 1144275009456 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275009457 GAF domain; Region: GAF; cl15785 1144275009458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275009459 metal binding site [ion binding]; metal-binding site 1144275009460 active site 1144275009461 I-site; other site 1144275009462 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275009463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009464 active site 1144275009465 phosphorylation site [posttranslational modification] 1144275009466 intermolecular recognition site; other site 1144275009467 dimerization interface [polypeptide binding]; other site 1144275009468 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009470 active site 1144275009471 phosphorylation site [posttranslational modification] 1144275009472 intermolecular recognition site; other site 1144275009473 dimerization interface [polypeptide binding]; other site 1144275009474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009475 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275009476 structural tetrad; other site 1144275009477 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1144275009478 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275009479 structural tetrad; other site 1144275009480 CHAT domain; Region: CHAT; pfam12770 1144275009481 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1144275009482 active site 1144275009483 substrate binding sites [chemical binding]; other site 1144275009484 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275009485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275009486 Coenzyme A binding pocket [chemical binding]; other site 1144275009487 Helix-turn-helix domains; Region: HTH; cl00088 1144275009488 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1144275009489 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1144275009490 active site 1144275009491 catalytic triad [active] 1144275009492 dimer interface [polypeptide binding]; other site 1144275009493 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275009494 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275009495 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1144275009496 Helix-turn-helix domains; Region: HTH; cl00088 1144275009497 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275009498 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275009499 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 1144275009500 short chain dehydrogenase; Provisional; Region: PRK06180 1144275009501 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1144275009502 NADP binding site [chemical binding]; other site 1144275009503 active site 1144275009504 steroid binding site; other site 1144275009505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275009506 Helix-turn-helix domains; Region: HTH; cl00088 1144275009507 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275009508 putative effector binding pocket; other site 1144275009509 putative dimerization interface [polypeptide binding]; other site 1144275009510 Transglycosylase; Region: Transgly; cl07896 1144275009511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275009512 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275009513 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275009514 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 1144275009515 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1144275009516 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1144275009517 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275009518 Glutaminase; Region: Glutaminase; cl00907 1144275009519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275009520 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1144275009521 dimer interface [polypeptide binding]; other site 1144275009522 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1144275009523 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1144275009524 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1144275009525 SpaB C-terminal domain; Region: SpaB_C; cl14828 1144275009526 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1144275009527 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1144275009528 active site 1144275009529 zinc binding site [ion binding]; other site 1144275009530 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1144275009531 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1144275009532 putative active site [active] 1144275009533 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275009534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009535 Walker A/P-loop; other site 1144275009536 ATP binding site [chemical binding]; other site 1144275009537 Q-loop/lid; other site 1144275009538 ABC transporter signature motif; other site 1144275009539 Walker B; other site 1144275009540 D-loop; other site 1144275009541 H-loop/switch region; other site 1144275009542 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3055 1144275009543 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275009544 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275009545 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275009546 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275009547 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275009548 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275009549 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1144275009550 Helix-turn-helix domains; Region: HTH; cl00088 1144275009551 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 1144275009552 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1144275009553 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 1144275009554 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1144275009555 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1144275009556 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009557 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1144275009558 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 1144275009559 hypothetical protein; Provisional; Region: PRK06185 1144275009560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009562 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1144275009563 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275009564 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275009565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009566 active site 1144275009567 phosphorylation site [posttranslational modification] 1144275009568 intermolecular recognition site; other site 1144275009569 dimerization interface [polypeptide binding]; other site 1144275009570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009571 Walker A motif; other site 1144275009572 ATP binding site [chemical binding]; other site 1144275009573 Walker B motif; other site 1144275009574 Helix-turn-helix domains; Region: HTH; cl00088 1144275009575 PAS fold; Region: PAS_4; pfam08448 1144275009576 PAS fold; Region: PAS_3; pfam08447 1144275009577 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275009578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009579 phosphorylation site [posttranslational modification] 1144275009580 dimer interface [polypeptide binding]; other site 1144275009581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009582 ATP binding site [chemical binding]; other site 1144275009583 Mg2+ binding site [ion binding]; other site 1144275009584 G-X-G motif; other site 1144275009585 OsmC-like protein; Region: OsmC; cl00767 1144275009586 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1144275009587 putative hydrophobic ligand binding site [chemical binding]; other site 1144275009588 protein interface [polypeptide binding]; other site 1144275009589 gate; other site 1144275009590 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1144275009591 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1144275009592 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1144275009593 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275009594 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1144275009595 putative di-iron ligands [ion binding]; other site 1144275009596 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275009597 dinuclear metal binding motif [ion binding]; other site 1144275009598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009599 ATP binding site [chemical binding]; other site 1144275009600 putative Mg++ binding site [ion binding]; other site 1144275009601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275009602 nucleotide binding region [chemical binding]; other site 1144275009603 ATP-binding site [chemical binding]; other site 1144275009604 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 1144275009605 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1144275009606 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1144275009607 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1144275009608 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1144275009609 FAD binding pocket [chemical binding]; other site 1144275009610 FAD binding motif [chemical binding]; other site 1144275009611 phosphate binding motif [ion binding]; other site 1144275009612 NAD binding pocket [chemical binding]; other site 1144275009613 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1144275009614 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275009615 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1144275009616 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1144275009617 putative hypoxanthine oxidase; Provisional; Region: PRK09800 1144275009618 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1144275009619 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275009620 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275009621 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275009622 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1144275009623 ThiC-associated domain; Region: ThiC-associated; pfam13667 1144275009624 ThiC family; Region: ThiC; cl08031 1144275009625 Tic20-like protein; Region: Tic20; pfam09685 1144275009626 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1144275009627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275009628 FeS/SAM binding site; other site 1144275009629 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1144275009630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009631 active site 1144275009632 phosphorylation site [posttranslational modification] 1144275009633 intermolecular recognition site; other site 1144275009634 dimerization interface [polypeptide binding]; other site 1144275009635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275009636 Zn2+ binding site [ion binding]; other site 1144275009637 Mg2+ binding site [ion binding]; other site 1144275009638 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1144275009639 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1144275009640 ATP phosphoribosyltransferase; Region: HisG; cl15266 1144275009641 HisG, C-terminal domain; Region: HisG_C; cl06867 1144275009642 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1144275009643 histidinol dehydrogenase; Region: hisD; TIGR00069 1144275009644 NAD binding site [chemical binding]; other site 1144275009645 dimerization interface [polypeptide binding]; other site 1144275009646 product binding site; other site 1144275009647 substrate binding site [chemical binding]; other site 1144275009648 zinc binding site [ion binding]; other site 1144275009649 catalytic residues [active] 1144275009650 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1144275009651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275009652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275009653 homodimer interface [polypeptide binding]; other site 1144275009654 catalytic residue [active] 1144275009655 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 1144275009656 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1144275009657 putative active site [active] 1144275009658 oxyanion strand; other site 1144275009659 catalytic triad [active] 1144275009660 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1144275009661 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1144275009662 catalytic residues [active] 1144275009663 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 1144275009664 4-fold oligomerization interface [polypeptide binding]; other site 1144275009665 putative active site pocket [active] 1144275009666 metal binding residues [ion binding]; metal-binding site 1144275009667 3-fold/trimer interface [polypeptide binding]; other site 1144275009668 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1144275009669 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1144275009670 substrate binding site [chemical binding]; other site 1144275009671 glutamase interaction surface [polypeptide binding]; other site 1144275009672 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1144275009673 active site 1144275009674 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1144275009675 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1144275009676 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1144275009677 metal binding site [ion binding]; metal-binding site 1144275009678 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1144275009679 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 1144275009680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275009681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1144275009682 Helix-turn-helix domains; Region: HTH; cl00088 1144275009683 WYL domain; Region: WYL; cl14852 1144275009684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009685 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1144275009686 NAD(P) binding site [chemical binding]; other site 1144275009687 active site 1144275009688 Bacterial Ig-like domain; Region: Big_5; cl01012 1144275009689 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275009690 MG2 domain; Region: A2M_N; pfam01835 1144275009691 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1144275009692 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1144275009693 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1144275009694 surface patch; other site 1144275009695 thioester region; other site 1144275009696 specificity defining residues; other site 1144275009697 Transglycosylase; Region: Transgly; cl07896 1144275009698 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1144275009699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275009700 Stage II sporulation protein; Region: SpoIID; pfam08486 1144275009701 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1144275009702 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275009703 ligand binding site [chemical binding]; other site 1144275009704 Protein of unknown function DUF72; Region: DUF72; cl00777 1144275009705 lipoyl synthase; Provisional; Region: PRK05481 1144275009706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275009707 FeS/SAM binding site; other site 1144275009708 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1144275009709 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1144275009710 E3 interaction surface; other site 1144275009711 lipoyl attachment site [posttranslational modification]; other site 1144275009712 e3 binding domain; Region: E3_binding; pfam02817 1144275009713 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1144275009714 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1144275009715 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1144275009716 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1144275009717 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1144275009718 nudix motif; other site 1144275009719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275009720 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1144275009721 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1144275009722 dimerization interface [polypeptide binding]; other site 1144275009723 active site 1144275009724 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1144275009725 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1144275009726 dimer interface [polypeptide binding]; other site 1144275009727 putative functional site; other site 1144275009728 putative MPT binding site; other site 1144275009729 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 1144275009730 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1144275009731 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275009732 RNB domain; Region: RNB; pfam00773 1144275009733 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1144275009734 RNA binding site [nucleotide binding]; other site 1144275009735 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 1144275009736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275009737 TPR motif; other site 1144275009738 binding surface 1144275009739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275009740 binding surface 1144275009741 TPR motif; other site 1144275009742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1144275009743 ABC-ATPase subunit interface; other site 1144275009744 dimer interface [polypeptide binding]; other site 1144275009745 putative PBP binding regions; other site 1144275009746 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1144275009747 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1144275009748 Walker A/P-loop; other site 1144275009749 ATP binding site [chemical binding]; other site 1144275009750 Q-loop/lid; other site 1144275009751 ABC transporter signature motif; other site 1144275009752 Walker B; other site 1144275009753 D-loop; other site 1144275009754 H-loop/switch region; other site 1144275009755 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1144275009756 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1144275009757 intersubunit interface [polypeptide binding]; other site 1144275009758 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 1144275009759 putative active site [active] 1144275009760 putative metal binding site [ion binding]; other site 1144275009761 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1144275009762 active site 1144275009763 catalytic residues [active] 1144275009764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275009765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1144275009766 active site 1144275009767 catalytic tetrad [active] 1144275009768 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1144275009769 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275009770 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1144275009771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275009772 dimer interface [polypeptide binding]; other site 1144275009773 conserved gate region; other site 1144275009774 putative PBP binding loops; other site 1144275009775 ABC-ATPase subunit interface; other site 1144275009776 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1144275009777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009778 Walker A/P-loop; other site 1144275009779 ATP binding site [chemical binding]; other site 1144275009780 Q-loop/lid; other site 1144275009781 ABC transporter signature motif; other site 1144275009782 Walker B; other site 1144275009783 D-loop; other site 1144275009784 H-loop/switch region; other site 1144275009785 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1144275009786 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1144275009787 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1144275009788 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1144275009789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275009790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275009791 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1144275009792 Helix-turn-helix domains; Region: HTH; cl00088 1144275009793 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1144275009794 dimerization interface [polypeptide binding]; other site 1144275009795 substrate binding pocket [chemical binding]; other site 1144275009796 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1144275009797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275009798 putative substrate translocation pore; other site 1144275009799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275009800 Helix-turn-helix domains; Region: HTH; cl00088 1144275009801 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1144275009802 putative effector binding pocket; other site 1144275009803 putative dimerization interface [polypeptide binding]; other site 1144275009804 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1144275009805 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275009806 putative NAD(P) binding site [chemical binding]; other site 1144275009807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275009808 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1144275009809 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1144275009810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275009811 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1144275009812 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275009813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275009814 FtsX-like permease family; Region: FtsX; cl15850 1144275009815 GAF domain; Region: GAF_2; pfam13185 1144275009816 GAF domain; Region: GAF; cl15785 1144275009817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009818 dimer interface [polypeptide binding]; other site 1144275009819 phosphorylation site [posttranslational modification] 1144275009820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009821 ATP binding site [chemical binding]; other site 1144275009822 Mg2+ binding site [ion binding]; other site 1144275009823 G-X-G motif; other site 1144275009824 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275009825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275009826 active site 1144275009827 phosphorylation site [posttranslational modification] 1144275009828 intermolecular recognition site; other site 1144275009829 dimerization interface [polypeptide binding]; other site 1144275009830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275009831 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275009832 putative active site [active] 1144275009833 heme pocket [chemical binding]; other site 1144275009834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009835 dimer interface [polypeptide binding]; other site 1144275009836 phosphorylation site [posttranslational modification] 1144275009837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009838 ATP binding site [chemical binding]; other site 1144275009839 Mg2+ binding site [ion binding]; other site 1144275009840 G-X-G motif; other site 1144275009841 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1144275009842 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275009843 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275009844 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1144275009845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009846 Walker A/P-loop; other site 1144275009847 ATP binding site [chemical binding]; other site 1144275009848 Q-loop/lid; other site 1144275009849 ABC transporter signature motif; other site 1144275009850 Walker B; other site 1144275009851 D-loop; other site 1144275009852 H-loop/switch region; other site 1144275009853 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1144275009854 Smr domain; Region: Smr; cl02619 1144275009855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275009856 binding surface 1144275009857 TPR motif; other site 1144275009858 cyclase homology domain; Region: CHD; cd07302 1144275009859 nucleotidyl binding site; other site 1144275009860 metal binding site [ion binding]; metal-binding site 1144275009861 dimer interface [polypeptide binding]; other site 1144275009862 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1144275009863 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275009864 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1144275009865 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1144275009866 active site 1144275009867 (T/H)XGH motif; other site 1144275009868 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275009869 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275009870 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1144275009871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009872 Walker A motif; other site 1144275009873 ATP binding site [chemical binding]; other site 1144275009874 Walker B motif; other site 1144275009875 arginine finger; other site 1144275009876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275009877 Walker A motif; other site 1144275009878 ATP binding site [chemical binding]; other site 1144275009879 Walker B motif; other site 1144275009880 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275009881 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275009882 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275009883 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275009884 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275009885 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275009886 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275009887 Walker A/P-loop; other site 1144275009888 ATP binding site [chemical binding]; other site 1144275009889 Q-loop/lid; other site 1144275009890 ABC transporter signature motif; other site 1144275009891 Walker B; other site 1144275009892 D-loop; other site 1144275009893 H-loop/switch region; other site 1144275009894 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275009895 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1144275009896 FtsX-like permease family; Region: FtsX; cl15850 1144275009897 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275009898 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1144275009899 FtsX-like permease family; Region: FtsX; cl15850 1144275009900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275009901 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275009902 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275009903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275009904 binding surface 1144275009905 TPR motif; other site 1144275009906 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1144275009907 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1144275009908 PYR/PP interface [polypeptide binding]; other site 1144275009909 dimer interface [polypeptide binding]; other site 1144275009910 TPP binding site [chemical binding]; other site 1144275009911 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1144275009912 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1144275009913 TPP-binding site [chemical binding]; other site 1144275009914 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275009915 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1144275009916 active site 1144275009917 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275009918 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275009919 active site 1144275009920 ATP binding site [chemical binding]; other site 1144275009921 substrate binding site [chemical binding]; other site 1144275009922 activation loop (A-loop); other site 1144275009923 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1144275009924 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1144275009925 ATP binding site [chemical binding]; other site 1144275009926 Mg++ binding site [ion binding]; other site 1144275009927 motif III; other site 1144275009928 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275009929 nucleotide binding region [chemical binding]; other site 1144275009930 ATP-binding site [chemical binding]; other site 1144275009931 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1144275009932 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1144275009933 Membrane glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: MdoH; COG2943 1144275009934 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1144275009935 Ligand binding site; other site 1144275009936 DXD motif; other site 1144275009937 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275009938 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1144275009939 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275009940 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 1144275009941 metal binding site [ion binding]; metal-binding site 1144275009942 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1144275009943 cyclase homology domain; Region: CHD; cd07302 1144275009944 nucleotidyl binding site; other site 1144275009945 metal binding site [ion binding]; metal-binding site 1144275009946 dimer interface [polypeptide binding]; other site 1144275009947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275009948 Predicted ATPase [General function prediction only]; Region: COG3903 1144275009949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275009950 TIGR02452 family protein; Region: TIGR02452 1144275009951 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1144275009952 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009953 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009954 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009955 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009956 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009957 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009958 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009959 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009960 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009961 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009962 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275009963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275009964 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1144275009965 putative active site [active] 1144275009966 heme pocket [chemical binding]; other site 1144275009967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275009968 putative active site [active] 1144275009969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275009970 heme pocket [chemical binding]; other site 1144275009971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275009972 dimer interface [polypeptide binding]; other site 1144275009973 phosphorylation site [posttranslational modification] 1144275009974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275009975 ATP binding site [chemical binding]; other site 1144275009976 Mg2+ binding site [ion binding]; other site 1144275009977 G-X-G motif; other site 1144275009978 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275009979 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1144275009980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275009981 NAD(P) binding site [chemical binding]; other site 1144275009982 active site 1144275009983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275009984 classical (c) SDRs; Region: SDR_c; cd05233 1144275009985 NAD(P) binding site [chemical binding]; other site 1144275009986 active site 1144275009987 Helix-turn-helix domains; Region: HTH; cl00088 1144275009988 Protein of unknown function (DUF692); Region: DUF692; cl01263 1144275009989 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1144275009990 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1144275009991 ATP-binding site [chemical binding]; other site 1144275009992 Sugar specificity; other site 1144275009993 Pyrimidine base specificity; other site 1144275009994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275009995 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275009996 PQQ-like domain; Region: PQQ_2; pfam13360 1144275009997 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1144275009998 active site 1144275009999 potential frameshift: common BLAST hit: gi|153005037|ref|YP_001379362.1| restriction endonuclease 1144275010000 Restriction endonuclease; Region: Mrr_cat; cl00516 1144275010001 HEAT repeats; Region: HEAT_2; pfam13646 1144275010002 HEAT repeats; Region: HEAT_2; pfam13646 1144275010003 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1144275010004 Helix-turn-helix domains; Region: HTH; cl00088 1144275010005 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1144275010006 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1144275010007 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1144275010008 potential frameshift: common BLAST hit: gi|108759929|ref|YP_632324.1| response regulator FrzS 1144275010009 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1144275010010 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 1144275010011 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275010012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010013 active site 1144275010014 phosphorylation site [posttranslational modification] 1144275010015 intermolecular recognition site; other site 1144275010016 dimerization interface [polypeptide binding]; other site 1144275010017 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1144275010018 Putative zinc-finger; Region: zf-HC2; cl15806 1144275010019 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275010020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275010021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275010022 DNA binding residues [nucleotide binding] 1144275010023 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1144275010024 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1144275010025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010026 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1144275010027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275010028 FeS/SAM binding site; other site 1144275010029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275010030 binding surface 1144275010031 TPR motif; other site 1144275010032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010033 active site 1144275010034 phosphorylation site [posttranslational modification] 1144275010035 intermolecular recognition site; other site 1144275010036 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275010037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010038 active site 1144275010039 phosphorylation site [posttranslational modification] 1144275010040 intermolecular recognition site; other site 1144275010041 dimerization interface [polypeptide binding]; other site 1144275010042 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275010043 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275010044 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275010045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275010046 dimer interface [polypeptide binding]; other site 1144275010047 putative CheW interface [polypeptide binding]; other site 1144275010048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275010049 putative binding surface; other site 1144275010050 active site 1144275010051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275010052 ATP binding site [chemical binding]; other site 1144275010053 Mg2+ binding site [ion binding]; other site 1144275010054 G-X-G motif; other site 1144275010055 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1144275010056 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275010057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010058 active site 1144275010059 phosphorylation site [posttranslational modification] 1144275010060 intermolecular recognition site; other site 1144275010061 dimerization interface [polypeptide binding]; other site 1144275010062 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275010063 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1144275010064 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1144275010065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275010066 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275010067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275010068 binding surface 1144275010069 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275010070 TPR motif; other site 1144275010071 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 1144275010072 photolyase PhrII; Region: phr2; TIGR00591 1144275010073 DNA photolyase; Region: DNA_photolyase; pfam00875 1144275010074 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1144275010075 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 1144275010076 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1144275010077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275010078 S-adenosylmethionine binding site [chemical binding]; other site 1144275010079 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 1144275010080 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275010081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010082 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1144275010083 Walker A/P-loop; other site 1144275010084 ATP binding site [chemical binding]; other site 1144275010085 Q-loop/lid; other site 1144275010086 ABC transporter signature motif; other site 1144275010087 Walker B; other site 1144275010088 D-loop; other site 1144275010089 H-loop/switch region; other site 1144275010090 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1144275010091 dimer interface [polypeptide binding]; other site 1144275010092 active site 1144275010093 Schiff base residues; other site 1144275010094 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 1144275010095 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275010096 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1144275010097 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 1144275010098 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275010099 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1144275010100 putative active site [active] 1144275010101 catalytic site [active] 1144275010102 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1144275010103 putative active site [active] 1144275010104 catalytic site [active] 1144275010105 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1144275010106 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1144275010107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275010108 Helix-turn-helix domains; Region: HTH; cl00088 1144275010109 WHG domain; Region: WHG; pfam13305 1144275010110 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1144275010111 homodimer interface [polypeptide binding]; other site 1144275010112 homotetramer interface [polypeptide binding]; other site 1144275010113 active site pocket [active] 1144275010114 cleavage site 1144275010115 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1144275010116 CotH protein; Region: CotH; pfam08757 1144275010117 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1144275010118 Predicted peptidase [General function prediction only]; Region: COG4099 1144275010119 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 1144275010120 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1144275010121 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275010122 active site 1144275010123 glutathione s-transferase; Provisional; Region: PTZ00057 1144275010124 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 1144275010125 GSH binding site (G-site) [chemical binding]; other site 1144275010126 C-terminal domain interface [polypeptide binding]; other site 1144275010127 dimer interface [polypeptide binding]; other site 1144275010128 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1144275010129 dimer interface [polypeptide binding]; other site 1144275010130 N-terminal domain interface [polypeptide binding]; other site 1144275010131 substrate binding pocket (H-site) [chemical binding]; other site 1144275010132 RNA polymerase sigma factor; Provisional; Region: PRK12513 1144275010133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275010134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275010135 DNA binding residues [nucleotide binding] 1144275010136 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275010137 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275010138 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1144275010139 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1144275010140 ATP binding site [chemical binding]; other site 1144275010141 Mg++ binding site [ion binding]; other site 1144275010142 motif III; other site 1144275010143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275010144 nucleotide binding region [chemical binding]; other site 1144275010145 ATP-binding site [chemical binding]; other site 1144275010146 Predicted esterase [General function prediction only]; Region: COG0627 1144275010147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010148 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1144275010149 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1144275010150 substrate binding site [chemical binding]; other site 1144275010151 catalytic Zn binding site [ion binding]; other site 1144275010152 NAD binding site [chemical binding]; other site 1144275010153 structural Zn binding site [ion binding]; other site 1144275010154 dimer interface [polypeptide binding]; other site 1144275010155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1144275010156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010157 active site 1144275010158 phosphorylation site [posttranslational modification] 1144275010159 intermolecular recognition site; other site 1144275010160 dimerization interface [polypeptide binding]; other site 1144275010161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275010162 DNA binding residues [nucleotide binding] 1144275010163 dimerization interface [polypeptide binding]; other site 1144275010164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275010165 Histidine kinase; Region: HisKA_3; pfam07730 1144275010166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275010167 ATP binding site [chemical binding]; other site 1144275010168 Mg2+ binding site [ion binding]; other site 1144275010169 G-X-G motif; other site 1144275010170 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1144275010171 ATP binding site [chemical binding]; other site 1144275010172 substrate interface [chemical binding]; other site 1144275010173 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1144275010174 CPxP motif; other site 1144275010175 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1144275010176 MoaE interaction surface [polypeptide binding]; other site 1144275010177 MoeB interaction surface [polypeptide binding]; other site 1144275010178 thiocarboxylated glycine; other site 1144275010179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010180 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1144275010181 MPN+ (JAMM) motif; other site 1144275010182 Zinc-binding site [ion binding]; other site 1144275010183 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1144275010184 ligand-binding site [chemical binding]; other site 1144275010185 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1144275010186 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1144275010187 Ligand Binding Site [chemical binding]; other site 1144275010188 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1144275010189 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1144275010190 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1144275010191 active site 1144275010192 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1144275010193 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1144275010194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275010196 Walker A motif; other site 1144275010197 ATP binding site [chemical binding]; other site 1144275010198 Walker B motif; other site 1144275010199 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275010200 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275010201 PrkA AAA domain; Region: AAA_PrkA; smart00763 1144275010202 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1144275010203 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275010204 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1144275010205 catalytic motif [active] 1144275010206 Zn binding site [ion binding]; other site 1144275010207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275010208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275010209 phosphorylation site [posttranslational modification] 1144275010210 dimer interface [polypeptide binding]; other site 1144275010211 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275010212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010213 active site 1144275010214 phosphorylation site [posttranslational modification] 1144275010215 intermolecular recognition site; other site 1144275010216 dimerization interface [polypeptide binding]; other site 1144275010217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275010218 Walker A motif; other site 1144275010219 ATP binding site [chemical binding]; other site 1144275010220 Walker B motif; other site 1144275010221 arginine finger; other site 1144275010222 Helix-turn-helix domains; Region: HTH; cl00088 1144275010223 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1144275010224 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275010225 DTAP/Switch II; other site 1144275010226 Switch I; other site 1144275010227 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275010228 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1144275010229 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275010230 P loop; other site 1144275010231 Nucleotide binding site [chemical binding]; other site 1144275010232 DTAP/Switch II; other site 1144275010233 Switch I; other site 1144275010234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275010235 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275010236 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1144275010237 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1144275010238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275010239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275010240 homodimer interface [polypeptide binding]; other site 1144275010241 catalytic residue [active] 1144275010242 cytidylate kinase; Provisional; Region: cmk; PRK00023 1144275010243 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1144275010244 CMP-binding site; other site 1144275010245 The sites determining sugar specificity; other site 1144275010246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1144275010247 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1144275010248 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275010249 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275010250 catalytic residue [active] 1144275010251 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1144275010252 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1144275010253 Protein of unknown function (DUF721); Region: DUF721; cl02324 1144275010254 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275010255 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275010256 phosphopeptide binding site; other site 1144275010257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275010258 metal binding site [ion binding]; metal-binding site 1144275010259 active site 1144275010260 I-site; other site 1144275010261 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1144275010262 putative acyl-acceptor binding pocket; other site 1144275010263 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1144275010264 putative NAD(P) binding site [chemical binding]; other site 1144275010265 active site 1144275010266 putative substrate binding site [chemical binding]; other site 1144275010267 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1144275010268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275010269 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1144275010270 ATP binding site [chemical binding]; other site 1144275010271 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1144275010272 YCII-related domain; Region: YCII; cl00999 1144275010273 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1144275010274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275010275 binding surface 1144275010276 TPR motif; other site 1144275010277 Cys-rich repeat, Myxococcales-type; Region: Myxo_Cys_RPT; TIGR04201 1144275010278 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275010279 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1144275010280 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1144275010281 GAF domain; Region: GAF; cl15785 1144275010282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275010283 Walker A motif; other site 1144275010284 ATP binding site [chemical binding]; other site 1144275010285 Walker B motif; other site 1144275010286 arginine finger; other site 1144275010287 Helix-turn-helix domains; Region: HTH; cl00088 1144275010288 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275010289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275010290 active site 1144275010291 ATP binding site [chemical binding]; other site 1144275010292 substrate binding site [chemical binding]; other site 1144275010293 activation loop (A-loop); other site 1144275010294 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1144275010295 active site 1144275010296 ADP/pyrophosphate binding site [chemical binding]; other site 1144275010297 dimerization interface [polypeptide binding]; other site 1144275010298 allosteric effector site; other site 1144275010299 fructose-1,6-bisphosphate binding site; other site 1144275010300 CAAX protease self-immunity; Region: Abi; cl00558 1144275010301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275010302 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275010303 acyl-CoA synthetase; Validated; Region: PRK05850 1144275010304 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010305 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010306 peptide synthase; Provisional; Region: PRK12316 1144275010307 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010308 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010309 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010310 peptide synthase; Provisional; Region: PRK12467 1144275010311 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010312 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010313 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010314 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010315 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010316 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010317 peptide synthase; Provisional; Region: PRK12467 1144275010318 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010319 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010320 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010321 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010322 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010323 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010324 peptide synthase; Provisional; Region: PRK12467 1144275010325 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010326 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010327 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010328 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010329 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010330 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010331 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010332 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010333 peptide synthase; Provisional; Region: PRK12316 1144275010334 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010335 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010336 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010337 peptide synthase; Provisional; Region: PRK12467 1144275010338 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010339 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010340 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010341 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275010342 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275010343 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275010344 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1144275010345 phosphopeptide binding site; other site 1144275010346 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275010347 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275010348 active site 1144275010349 catalytic tetrad [active] 1144275010350 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275010351 Cytochrome P450; Region: p450; pfam00067 1144275010352 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1144275010353 ATP-dependent protease La; Region: lon; TIGR00763 1144275010354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275010355 Walker A motif; other site 1144275010356 ATP binding site [chemical binding]; other site 1144275010357 Walker B motif; other site 1144275010358 arginine finger; other site 1144275010359 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1144275010360 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275010361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010362 Walker A motif; other site 1144275010363 ATP binding site [chemical binding]; other site 1144275010364 Walker B motif; other site 1144275010365 DNA Polymerase Y-family; Region: PolY_like; cd03468 1144275010366 active site 1144275010367 DNA polymerase IV; Validated; Region: PRK03858 1144275010368 DNA binding site [nucleotide binding] 1144275010369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275010370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010371 NAD(P) binding site [chemical binding]; other site 1144275010372 active site 1144275010373 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010374 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010375 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010376 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010377 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010378 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010379 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010380 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010381 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010382 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010383 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010384 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010385 Uncharacterized conserved protein [Function unknown]; Region: COG1572 1144275010386 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275010387 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1144275010388 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275010389 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275010390 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1144275010391 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1144275010392 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1144275010393 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275010394 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010395 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010396 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1144275010397 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1144275010398 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1144275010399 generic binding surface II; other site 1144275010400 generic binding surface I; other site 1144275010401 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275010402 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275010403 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275010404 active site 1144275010405 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1144275010406 WbqC-like protein family; Region: WbqC; pfam08889 1144275010407 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275010408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275010409 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010410 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275010411 Lamin Tail Domain; Region: LTD; pfam00932 1144275010412 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275010413 putative catalytic site [active] 1144275010414 putative metal binding site [ion binding]; other site 1144275010415 putative phosphate binding site [ion binding]; other site 1144275010416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275010417 putative acyl-acceptor binding pocket; other site 1144275010418 circadian clock protein KaiC; Reviewed; Region: PRK09302 1144275010419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010420 Walker A motif; other site 1144275010421 ATP binding site [chemical binding]; other site 1144275010422 Walker B motif; other site 1144275010423 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010424 Walker A motif; other site 1144275010425 ATP binding site [chemical binding]; other site 1144275010426 Walker B motif; other site 1144275010427 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275010428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275010429 active site 1144275010430 phosphorylation site [posttranslational modification] 1144275010431 intermolecular recognition site; other site 1144275010432 dimerization interface [polypeptide binding]; other site 1144275010433 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 1144275010434 Helix-turn-helix domains; Region: HTH; cl00088 1144275010435 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1144275010436 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1144275010437 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1144275010438 active site 1144275010439 catalytic residues [active] 1144275010440 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1144275010441 substrate binding site [chemical binding]; other site 1144275010442 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1144275010443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1144275010444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275010445 dimer interface [polypeptide binding]; other site 1144275010446 conserved gate region; other site 1144275010447 putative PBP binding loops; other site 1144275010448 ABC-ATPase subunit interface; other site 1144275010449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275010450 dimer interface [polypeptide binding]; other site 1144275010451 conserved gate region; other site 1144275010452 putative PBP binding loops; other site 1144275010453 ABC-ATPase subunit interface; other site 1144275010454 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1144275010455 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1144275010456 Walker A/P-loop; other site 1144275010457 ATP binding site [chemical binding]; other site 1144275010458 Q-loop/lid; other site 1144275010459 ABC transporter signature motif; other site 1144275010460 Walker B; other site 1144275010461 D-loop; other site 1144275010462 H-loop/switch region; other site 1144275010463 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1144275010464 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1144275010465 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1144275010466 Walker A/P-loop; other site 1144275010467 ATP binding site [chemical binding]; other site 1144275010468 Q-loop/lid; other site 1144275010469 ABC transporter signature motif; other site 1144275010470 Walker B; other site 1144275010471 D-loop; other site 1144275010472 H-loop/switch region; other site 1144275010473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1144275010474 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1144275010475 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275010476 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275010477 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1144275010478 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1144275010479 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1144275010480 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275010481 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275010482 Zn binding site [ion binding]; other site 1144275010483 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1144275010484 putative hydrophobic ligand binding site [chemical binding]; other site 1144275010485 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275010486 structural tetrad; other site 1144275010487 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275010488 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1144275010489 Isochorismatase family; Region: Isochorismatase; pfam00857 1144275010490 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1144275010491 catalytic triad [active] 1144275010492 conserved cis-peptide bond; other site 1144275010493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1144275010494 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1144275010495 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275010496 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275010497 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1144275010498 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1144275010499 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1144275010500 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1144275010501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275010502 N-terminal plug; other site 1144275010503 ligand-binding site [chemical binding]; other site 1144275010504 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275010505 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1144275010506 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275010507 Ligand Binding Site [chemical binding]; other site 1144275010508 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275010509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010510 NAD(P) binding site [chemical binding]; other site 1144275010511 active site 1144275010512 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275010513 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1144275010514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010515 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 1144275010516 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275010517 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1144275010518 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1144275010519 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275010520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275010521 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275010522 DNA binding residues [nucleotide binding] 1144275010523 Uncharacterized conserved protein [Function unknown]; Region: COG0585 1144275010524 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1144275010525 active site 1144275010526 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1144275010527 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1144275010528 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275010529 phosphopeptide binding site; other site 1144275010530 GAF domain; Region: GAF_2; pfam13185 1144275010531 GAF domain; Region: GAF; cl15785 1144275010532 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1144275010533 cyclase homology domain; Region: CHD; cd07302 1144275010534 nucleotidyl binding site; other site 1144275010535 metal binding site [ion binding]; metal-binding site 1144275010536 dimer interface [polypeptide binding]; other site 1144275010537 Protein kinase domain; Region: Pkinase; pfam00069 1144275010538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275010539 active site 1144275010540 ATP binding site [chemical binding]; other site 1144275010541 substrate binding site [chemical binding]; other site 1144275010542 activation loop (A-loop); other site 1144275010543 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275010544 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1144275010545 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275010546 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1144275010547 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275010548 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275010549 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275010550 PA14 domain; Region: PA14; cl08459 1144275010551 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1144275010552 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1144275010553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275010554 putative substrate translocation pore; other site 1144275010555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275010556 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1144275010557 GAF domain; Region: GAF; cl15785 1144275010558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275010559 Walker A motif; other site 1144275010560 ATP binding site [chemical binding]; other site 1144275010561 Walker B motif; other site 1144275010562 arginine finger; other site 1144275010563 Helix-turn-helix domains; Region: HTH; cl00088 1144275010564 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275010565 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1144275010566 active site 1144275010567 DNA binding site [nucleotide binding] 1144275010568 Int/Topo IB signature motif; other site 1144275010569 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1144275010570 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275010571 Phage capsid family; Region: Phage_capsid; pfam05065 1144275010572 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1144275010573 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1144275010574 Uncharacterized conserved protein [Function unknown]; Region: COG5323 1144275010575 Podovirus DNA encapsidation protein (Gp16); Region: Podovirus_Gp16; cl11625 1144275010576 NlpC/P60 family; Region: NLPC_P60; cl11438 1144275010577 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1144275010578 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1144275010579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275010580 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1144275010581 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1144275010582 DNA-sulfur modification-associated; Region: DndB; cl14002 1144275010583 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1144275010584 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275010585 Magnesium ion binding site [ion binding]; other site 1144275010586 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275010587 Magnesium ion binding site [ion binding]; other site 1144275010588 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1144275010589 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1144275010590 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010591 Glutaminase; Region: Glutaminase; cl00907 1144275010592 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1144275010593 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275010595 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1144275010596 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1144275010597 DNA binding residues [nucleotide binding] 1144275010598 putative dimer interface [polypeptide binding]; other site 1144275010599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275010600 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1144275010601 putative active site [active] 1144275010602 putative metal binding site [ion binding]; other site 1144275010603 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275010604 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 1144275010605 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1144275010606 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1144275010607 active site 1144275010608 zinc binding site [ion binding]; other site 1144275010609 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1144275010610 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1144275010611 ATP binding site [chemical binding]; other site 1144275010612 Mg++ binding site [ion binding]; other site 1144275010613 motif III; other site 1144275010614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275010615 nucleotide binding region [chemical binding]; other site 1144275010616 ATP-binding site [chemical binding]; other site 1144275010617 DbpA RNA binding domain; Region: DbpA; pfam03880 1144275010618 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1144275010619 SpoOM protein; Region: Spo0M; pfam07070 1144275010620 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1144275010621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010622 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1144275010623 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275010624 CoenzymeA binding site [chemical binding]; other site 1144275010625 subunit interaction site [polypeptide binding]; other site 1144275010626 PHB binding site; other site 1144275010627 Helix-turn-helix domains; Region: HTH; cl00088 1144275010628 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275010629 putative effector binding pocket; other site 1144275010630 dimerization interface [polypeptide binding]; other site 1144275010631 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1144275010632 mce related protein; Region: MCE; pfam02470 1144275010633 T-complex protein 11; Region: Tcp11; pfam05794 1144275010634 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1144275010635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010636 Walker A/P-loop; other site 1144275010637 ATP binding site [chemical binding]; other site 1144275010638 Q-loop/lid; other site 1144275010639 ABC transporter signature motif; other site 1144275010640 Walker B; other site 1144275010641 D-loop; other site 1144275010642 H-loop/switch region; other site 1144275010643 Permease; Region: Permease; cl00510 1144275010644 Permease; Region: Permease; cl00510 1144275010645 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275010646 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275010647 Walker A/P-loop; other site 1144275010648 ATP binding site [chemical binding]; other site 1144275010649 Q-loop/lid; other site 1144275010650 ABC transporter signature motif; other site 1144275010651 Walker B; other site 1144275010652 D-loop; other site 1144275010653 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275010654 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275010655 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275010656 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275010657 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275010658 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275010659 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1144275010660 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 1144275010661 short chain dehydrogenase; Provisional; Region: PRK07832 1144275010662 classical (c) SDRs; Region: SDR_c; cd05233 1144275010663 NAD(P) binding site [chemical binding]; other site 1144275010664 active site 1144275010665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1144275010666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275010667 Helix-turn-helix domains; Region: HTH; cl00088 1144275010668 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1144275010669 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1144275010670 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1144275010671 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275010672 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1144275010673 active site 1144275010674 ATP binding site [chemical binding]; other site 1144275010675 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1144275010676 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1144275010677 MutS domain I; Region: MutS_I; pfam01624 1144275010678 MutS domain II; Region: MutS_II; pfam05188 1144275010679 MutS family domain IV; Region: MutS_IV; pfam05190 1144275010680 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 1144275010681 Walker A/P-loop; other site 1144275010682 ATP binding site [chemical binding]; other site 1144275010683 Q-loop/lid; other site 1144275010684 ABC transporter signature motif; other site 1144275010685 Walker B; other site 1144275010686 D-loop; other site 1144275010687 H-loop/switch region; other site 1144275010688 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 1144275010689 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275010690 active site 1144275010691 ATP binding site [chemical binding]; other site 1144275010692 substrate binding site [chemical binding]; other site 1144275010693 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275010694 substrate binding site [chemical binding]; other site 1144275010695 activation loop (A-loop); other site 1144275010696 activation loop (A-loop); other site 1144275010697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275010698 non-specific DNA binding site [nucleotide binding]; other site 1144275010699 sequence-specific DNA binding site [nucleotide binding]; other site 1144275010700 salt bridge; other site 1144275010701 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275010702 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275010703 active site 1144275010704 ATP binding site [chemical binding]; other site 1144275010705 substrate binding site [chemical binding]; other site 1144275010706 activation loop (A-loop); other site 1144275010707 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275010708 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275010709 Ligand Binding Site [chemical binding]; other site 1144275010710 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275010711 Ligand Binding Site [chemical binding]; other site 1144275010712 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275010713 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1144275010714 active site 1144275010715 metal binding site [ion binding]; metal-binding site 1144275010716 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1144275010717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275010718 ATP binding site [chemical binding]; other site 1144275010719 putative Mg++ binding site [ion binding]; other site 1144275010720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275010721 nucleotide binding region [chemical binding]; other site 1144275010722 ATP-binding site [chemical binding]; other site 1144275010723 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1144275010724 dimer interface [polypeptide binding]; other site 1144275010725 substrate binding site [chemical binding]; other site 1144275010726 ATP binding site [chemical binding]; other site 1144275010727 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1144275010728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275010730 Helix-turn-helix domains; Region: HTH; cl00088 1144275010731 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275010732 putative effector binding pocket; other site 1144275010733 dimerization interface [polypeptide binding]; other site 1144275010734 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275010735 Small hydrophilic plant seed protein; Region: LEA_5; pfam00477 1144275010736 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1144275010737 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1144275010738 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1144275010739 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1144275010740 active site 1144275010741 Int/Topo IB signature motif; other site 1144275010742 VID27 cytoplasmic protein; Region: VID27; pfam08553 1144275010743 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275010744 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1144275010745 C-terminal domain interface [polypeptide binding]; other site 1144275010746 GSH binding site (G-site) [chemical binding]; other site 1144275010747 dimer interface [polypeptide binding]; other site 1144275010748 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275010749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275010750 PAS fold; Region: PAS; pfam00989 1144275010751 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 1144275010752 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1144275010753 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1144275010754 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1144275010755 active site 1144275010756 HIGH motif; other site 1144275010757 dimer interface [polypeptide binding]; other site 1144275010758 KMSKS motif; other site 1144275010759 ScpA/B protein; Region: ScpA_ScpB; cl00598 1144275010760 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1144275010761 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1144275010762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1144275010763 RNA binding surface [nucleotide binding]; other site 1144275010764 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1144275010765 active site 1144275010766 HEAT repeats; Region: HEAT_2; pfam13646 1144275010767 HEAT repeats; Region: HEAT_2; pfam13646 1144275010768 TPR repeat; Region: TPR_11; pfam13414 1144275010769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275010770 binding surface 1144275010771 TPR motif; other site 1144275010772 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275010773 ligand binding site [chemical binding]; other site 1144275010774 flexible hinge region; other site 1144275010775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275010776 ligand binding site [chemical binding]; other site 1144275010777 flexible hinge region; other site 1144275010778 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275010779 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010780 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1144275010781 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 1144275010782 Protein of unknown function (DUF770); Region: DUF770; cl01402 1144275010783 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1144275010784 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1144275010785 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1144275010786 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1144275010787 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1144275010788 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1144275010789 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1144275010790 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1144275010791 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1144275010792 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1144275010793 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1144275010794 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275010795 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275010796 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1144275010797 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1144275010798 transmembrane helices; other site 1144275010799 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1144275010800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275010801 ATP binding site [chemical binding]; other site 1144275010802 putative Mg++ binding site [ion binding]; other site 1144275010803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275010804 nucleotide binding region [chemical binding]; other site 1144275010805 ATP-binding site [chemical binding]; other site 1144275010806 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1144275010807 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1144275010808 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1144275010809 active site 1144275010810 substrate binding site [chemical binding]; other site 1144275010811 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1144275010812 carboxyltransferase (CT) interaction site; other site 1144275010813 biotinylation site [posttranslational modification]; other site 1144275010814 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275010815 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275010816 ligand binding site [chemical binding]; other site 1144275010817 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1144275010818 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 1144275010819 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1144275010820 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275010821 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275010822 FeS/SAM binding site; other site 1144275010823 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1144275010824 HemN C-terminal domain; Region: HemN_C; pfam06969 1144275010825 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1144275010826 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 1144275010827 active site 1144275010828 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1144275010829 catalytic triad [active] 1144275010830 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 1144275010831 Predicted acyl esterases [General function prediction only]; Region: COG2936 1144275010832 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275010833 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1144275010834 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1144275010835 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 1144275010836 putative active site [active] 1144275010837 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1144275010838 tandem repeat interface [polypeptide binding]; other site 1144275010839 oligomer interface [polypeptide binding]; other site 1144275010840 active site residues [active] 1144275010841 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1144275010842 oligomer interface [polypeptide binding]; other site 1144275010843 tandem repeat interface [polypeptide binding]; other site 1144275010844 active site residues [active] 1144275010845 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1144275010846 substrate binding site [chemical binding]; other site 1144275010847 Cupin domain; Region: Cupin_2; cl09118 1144275010848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275010849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275010850 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1144275010851 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1144275010852 antiporter inner membrane protein; Provisional; Region: PRK11670 1144275010853 Domain of unknown function DUF59; Region: DUF59; cl00941 1144275010854 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1144275010855 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1144275010856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275010857 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1144275010858 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1144275010859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275010860 substrate binding site [chemical binding]; other site 1144275010861 oxyanion hole (OAH) forming residues; other site 1144275010862 trimer interface [polypeptide binding]; other site 1144275010863 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275010864 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1144275010865 FAD binding site [chemical binding]; other site 1144275010866 homotetramer interface [polypeptide binding]; other site 1144275010867 substrate binding pocket [chemical binding]; other site 1144275010868 catalytic base [active] 1144275010869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275010870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275010871 active site 1144275010872 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1144275010873 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1144275010874 RNA binding site [nucleotide binding]; other site 1144275010875 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1144275010876 RNA binding site [nucleotide binding]; other site 1144275010877 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 1144275010878 RNA binding site [nucleotide binding]; other site 1144275010879 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275010880 RNA binding site [nucleotide binding]; other site 1144275010881 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275010882 RNA binding site [nucleotide binding]; other site 1144275010883 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1144275010884 RNA binding site [nucleotide binding]; other site 1144275010885 putative acyltransferase; Provisional; Region: PRK05790 1144275010886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1144275010887 dimer interface [polypeptide binding]; other site 1144275010888 active site 1144275010889 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1144275010890 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1144275010891 PilZ domain; Region: PilZ; cl01260 1144275010892 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1144275010893 TRAM domain; Region: TRAM; cl01282 1144275010894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275010895 S-adenosylmethionine binding site [chemical binding]; other site 1144275010896 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275010897 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1144275010898 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1144275010899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275010900 FeS/SAM binding site; other site 1144275010901 TRAM domain; Region: TRAM; cl01282 1144275010902 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1144275010903 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1144275010904 trimer interface [polypeptide binding]; other site 1144275010905 putative metal binding site [ion binding]; other site 1144275010906 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275010907 ligand binding site [chemical binding]; other site 1144275010908 flexible hinge region; other site 1144275010909 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275010910 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1144275010911 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010912 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010913 peptide synthase; Provisional; Region: PRK12467 1144275010914 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010915 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010916 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010917 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010918 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010919 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010920 peptide synthase; Provisional; Region: PRK12467 1144275010921 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010922 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010923 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275010924 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275010925 active site 1144275010926 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275010927 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275010928 peptide synthase; Provisional; Region: PRK12467 1144275010929 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010930 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010931 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275010932 peptide synthase; Provisional; Region: PRK12316 1144275010933 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010934 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010935 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010936 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1144275010937 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010938 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010940 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010941 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010942 peptide synthase; Provisional; Region: PRK12316 1144275010943 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010944 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010945 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010946 peptide synthase; Provisional; Region: PRK12467 1144275010947 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010948 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010949 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010950 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1144275010951 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010952 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010953 Condensation domain; Region: Condensation; pfam00668 1144275010954 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275010955 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010956 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010957 acyl-CoA synthetase; Validated; Region: PRK08308 1144275010958 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010959 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275010960 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275010961 active site 1144275010962 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275010963 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275010964 peptide synthase; Provisional; Region: PRK12467 1144275010965 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010966 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010967 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275010968 peptide synthase; Provisional; Region: PRK12467 1144275010969 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010970 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010971 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010972 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1144275010973 peptide synthase; Provisional; Region: PRK12316 1144275010974 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010975 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010976 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1144275010977 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010978 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010979 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010980 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010981 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010982 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010983 peptide synthase; Provisional; Region: PRK12316 1144275010984 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010985 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010986 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010987 peptide synthase; Provisional; Region: PRK12467 1144275010988 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275010989 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275010990 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275010991 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275010992 PilZ domain; Region: PilZ; cl01260 1144275010993 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275010994 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1144275010995 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1144275010996 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1144275010997 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1144275010998 active site 1144275010999 GMP synthase; Reviewed; Region: guaA; PRK00074 1144275011000 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1144275011001 AMP/PPi binding site [chemical binding]; other site 1144275011002 candidate oxyanion hole; other site 1144275011003 catalytic triad [active] 1144275011004 potential glutamine specificity residues [chemical binding]; other site 1144275011005 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1144275011006 ATP Binding subdomain [chemical binding]; other site 1144275011007 Ligand Binding sites [chemical binding]; other site 1144275011008 Dimerization subdomain; other site 1144275011009 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1144275011010 Peptidase S46; Region: Peptidase_S46; pfam10459 1144275011011 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275011012 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1144275011013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275011014 Helix-turn-helix domain; Region: HTH_18; pfam12833 1144275011015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275011016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275011017 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1144275011018 Amidohydrolase; Region: Amidohydro_4; pfam13147 1144275011019 active site 1144275011020 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275011021 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275011022 active site 1144275011023 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1144275011024 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275011025 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275011026 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275011027 active site 1144275011028 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275011029 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275011030 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011031 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275011032 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011033 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011034 Condensation domain; Region: Condensation; pfam00668 1144275011035 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275011036 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011037 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011038 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011039 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011040 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275011041 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275011042 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275011043 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275011044 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275011045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275011046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275011047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275011048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275011049 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1144275011050 Catalytic site [active] 1144275011051 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275011052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275011053 Walker A/P-loop; other site 1144275011054 ATP binding site [chemical binding]; other site 1144275011055 Q-loop/lid; other site 1144275011056 ABC transporter signature motif; other site 1144275011057 Walker B; other site 1144275011058 D-loop; other site 1144275011059 H-loop/switch region; other site 1144275011060 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275011061 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011062 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011063 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011064 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011065 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011066 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011067 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275011068 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011069 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011070 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011071 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011072 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275011073 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1144275011074 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1144275011075 catalytic residues [active] 1144275011076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275011077 Helix-turn-helix domains; Region: HTH; cl00088 1144275011078 Chromate transporter; Region: Chromate_transp; pfam02417 1144275011079 Chromate transporter; Region: Chromate_transp; pfam02417 1144275011080 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 1144275011081 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1144275011082 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1144275011083 active site 1144275011084 8-oxo-dGMP binding site [chemical binding]; other site 1144275011085 nudix motif; other site 1144275011086 metal binding site [ion binding]; metal-binding site 1144275011087 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1144275011088 PQQ-like domain; Region: PQQ_2; pfam13360 1144275011089 Trp docking motif [polypeptide binding]; other site 1144275011090 active site 1144275011091 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275011092 potential frameshift: common BLAST hit: gi|310821559|ref|YP_003953917.1| GTP-binding protein EngA 1144275011093 GTP-binding protein Der; Reviewed; Region: PRK00093 1144275011094 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1144275011095 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1144275011096 G1 box; other site 1144275011097 GTP/Mg2+ binding site [chemical binding]; other site 1144275011098 Switch I region; other site 1144275011099 G2 box; other site 1144275011100 Switch II region; other site 1144275011101 G3 box; other site 1144275011102 G4 box; other site 1144275011103 G5 box; other site 1144275011104 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1144275011105 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1144275011106 G1 box; other site 1144275011107 GTP/Mg2+ binding site [chemical binding]; other site 1144275011108 Switch I region; other site 1144275011109 G2 box; other site 1144275011110 G3 box; other site 1144275011111 Switch II region; other site 1144275011112 G4 box; other site 1144275011113 G5 box; other site 1144275011114 GTPase Era; Reviewed; Region: era; PRK00089 1144275011115 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1144275011116 G1 box; other site 1144275011117 GTP/Mg2+ binding site [chemical binding]; other site 1144275011118 Switch I region; other site 1144275011119 G2 box; other site 1144275011120 Switch II region; other site 1144275011121 G3 box; other site 1144275011122 G4 box; other site 1144275011123 G5 box; other site 1144275011124 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1144275011125 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1144275011126 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1144275011127 active site 1144275011128 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 1144275011129 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1144275011130 active site 1144275011131 ribonuclease III; Reviewed; Region: rnc; PRK00102 1144275011132 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1144275011133 dimerization interface [polypeptide binding]; other site 1144275011134 active site 1144275011135 metal binding site [ion binding]; metal-binding site 1144275011136 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1144275011137 dsRNA binding site [nucleotide binding]; other site 1144275011138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275011139 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275011140 active site 1144275011141 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1144275011142 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275011143 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275011144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275011145 enoyl-CoA hydratase; Provisional; Region: PRK07657 1144275011146 substrate binding site [chemical binding]; other site 1144275011147 oxyanion hole (OAH) forming residues; other site 1144275011148 trimer interface [polypeptide binding]; other site 1144275011149 Tim44-like domain; Region: Tim44; cl09208 1144275011150 tellurium resistance terB-like protein; Region: terB_like; cd07177 1144275011151 metal binding site [ion binding]; metal-binding site 1144275011152 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1144275011153 active site 1144275011154 catalytic residues [active] 1144275011155 metal binding site [ion binding]; metal-binding site 1144275011156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275011157 S-adenosylmethionine binding site [chemical binding]; other site 1144275011158 aminotransferase; Validated; Region: PRK07777 1144275011159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275011160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275011161 homodimer interface [polypeptide binding]; other site 1144275011162 catalytic residue [active] 1144275011163 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1144275011164 active site 1144275011165 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1144275011166 Protein export membrane protein; Region: SecD_SecF; cl14618 1144275011167 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1144275011168 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1144275011169 substrate-cofactor binding pocket; other site 1144275011170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275011171 catalytic residue [active] 1144275011172 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1144275011173 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275011174 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1144275011175 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1144275011176 putative active site; other site 1144275011177 catalytic residue [active] 1144275011178 GAF domain; Region: GAF_2; pfam13185 1144275011179 GAF domain; Region: GAF; cl15785 1144275011180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275011181 dimer interface [polypeptide binding]; other site 1144275011182 phosphorylation site [posttranslational modification] 1144275011183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275011184 ATP binding site [chemical binding]; other site 1144275011185 Mg2+ binding site [ion binding]; other site 1144275011186 G-X-G motif; other site 1144275011187 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275011188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011189 active site 1144275011190 phosphorylation site [posttranslational modification] 1144275011191 intermolecular recognition site; other site 1144275011192 dimerization interface [polypeptide binding]; other site 1144275011193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275011194 PAS fold; Region: PAS_3; pfam08447 1144275011195 putative active site [active] 1144275011196 heme pocket [chemical binding]; other site 1144275011197 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275011198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275011199 putative active site [active] 1144275011200 heme pocket [chemical binding]; other site 1144275011201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275011202 dimer interface [polypeptide binding]; other site 1144275011203 phosphorylation site [posttranslational modification] 1144275011204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275011205 ATP binding site [chemical binding]; other site 1144275011206 Mg2+ binding site [ion binding]; other site 1144275011207 G-X-G motif; other site 1144275011208 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1144275011209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275011210 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275011211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011212 active site 1144275011213 phosphorylation site [posttranslational modification] 1144275011214 intermolecular recognition site; other site 1144275011215 dimerization interface [polypeptide binding]; other site 1144275011216 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1144275011217 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275011218 TPR motif; other site 1144275011219 binding surface 1144275011220 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275011221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011222 active site 1144275011223 phosphorylation site [posttranslational modification] 1144275011224 intermolecular recognition site; other site 1144275011225 dimerization interface [polypeptide binding]; other site 1144275011226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275011227 metal binding site [ion binding]; metal-binding site 1144275011228 active site 1144275011229 I-site; other site 1144275011230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011231 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275011232 active site 1144275011233 phosphorylation site [posttranslational modification] 1144275011234 intermolecular recognition site; other site 1144275011235 dimerization interface [polypeptide binding]; other site 1144275011236 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1144275011237 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275011238 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1144275011239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275011240 PQQ-like domain; Region: PQQ_2; pfam13360 1144275011241 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1144275011242 active site 1144275011243 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1144275011244 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1144275011245 Catalytic site [active] 1144275011246 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1144275011247 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1144275011248 dimer interface [polypeptide binding]; other site 1144275011249 motif 1; other site 1144275011250 active site 1144275011251 motif 2; other site 1144275011252 motif 3; other site 1144275011253 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1144275011254 anticodon binding site; other site 1144275011255 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1144275011256 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275011257 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1144275011258 active site 1144275011259 metal binding site [ion binding]; metal-binding site 1144275011260 PilZ domain; Region: PilZ; cl01260 1144275011261 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1144275011262 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 1144275011263 substrate binding site [chemical binding]; other site 1144275011264 ATP binding site [chemical binding]; other site 1144275011265 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1144275011266 mce related protein; Region: MCE; pfam02470 1144275011267 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1144275011268 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 1144275011269 Walker A/P-loop; other site 1144275011270 ATP binding site [chemical binding]; other site 1144275011271 Q-loop/lid; other site 1144275011272 ABC transporter signature motif; other site 1144275011273 Walker B; other site 1144275011274 D-loop; other site 1144275011275 H-loop/switch region; other site 1144275011276 Permease; Region: Permease; cl00510 1144275011277 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275011278 active site 1144275011279 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275011280 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275011281 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275011282 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275011283 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275011284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275011285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1144275011286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011287 active site 1144275011288 phosphorylation site [posttranslational modification] 1144275011289 intermolecular recognition site; other site 1144275011290 dimerization interface [polypeptide binding]; other site 1144275011291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275011292 DNA binding residues [nucleotide binding] 1144275011293 dimerization interface [polypeptide binding]; other site 1144275011294 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275011295 active site 1144275011296 ATP binding site [chemical binding]; other site 1144275011297 substrate binding site [chemical binding]; other site 1144275011298 activation loop (A-loop); other site 1144275011299 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1144275011300 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275011301 HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase; Region: HAD-IG-Ncltidse; TIGR02244 1144275011302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275011303 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 1144275011304 GAF domain; Region: GAF_2; pfam13185 1144275011305 GAF domain; Region: GAF; cl15785 1144275011306 GAF domain; Region: GAF_2; pfam13185 1144275011307 GAF domain; Region: GAF; cl15785 1144275011308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275011309 metal binding site [ion binding]; metal-binding site 1144275011310 active site 1144275011311 I-site; other site 1144275011312 Septum formation initiator; Region: DivIC; cl11433 1144275011313 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1144275011314 catalytic residues [active] 1144275011315 ferric uptake regulator; Provisional; Region: fur; PRK09462 1144275011316 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1144275011317 metal binding site 2 [ion binding]; metal-binding site 1144275011318 putative DNA binding helix; other site 1144275011319 metal binding site 1 [ion binding]; metal-binding site 1144275011320 dimer interface [polypeptide binding]; other site 1144275011321 structural Zn2+ binding site [ion binding]; other site 1144275011322 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1144275011323 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1144275011324 potential frameshift: common BLAST hit: gi|108757027|ref|YP_631885.1| lipoprotein 1144275011325 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1144275011326 PHP-associated; Region: PHP_C; pfam13263 1144275011327 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275011328 phosphopeptide binding site; other site 1144275011329 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275011330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275011331 Walker A motif; other site 1144275011332 ATP binding site [chemical binding]; other site 1144275011333 Walker B motif; other site 1144275011334 arginine finger; other site 1144275011335 Helix-turn-helix domains; Region: HTH; cl00088 1144275011336 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275011337 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275011338 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275011339 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1144275011340 active site 1144275011341 nucleophile elbow; other site 1144275011342 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1144275011343 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1144275011344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275011345 Helix-turn-helix domains; Region: HTH; cl00088 1144275011346 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275011347 putative effector binding pocket; other site 1144275011348 putative dimerization interface [polypeptide binding]; other site 1144275011349 short chain dehydrogenase; Provisional; Region: PRK06180 1144275011350 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1144275011351 NADP binding site [chemical binding]; other site 1144275011352 active site 1144275011353 steroid binding site; other site 1144275011354 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1144275011355 putative active site [active] 1144275011356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275011357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011358 active site 1144275011359 phosphorylation site [posttranslational modification] 1144275011360 intermolecular recognition site; other site 1144275011361 dimerization interface [polypeptide binding]; other site 1144275011362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275011363 DNA binding site [nucleotide binding] 1144275011364 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275011365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275011366 dimer interface [polypeptide binding]; other site 1144275011367 phosphorylation site [posttranslational modification] 1144275011368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275011369 ATP binding site [chemical binding]; other site 1144275011370 Mg2+ binding site [ion binding]; other site 1144275011371 G-X-G motif; other site 1144275011372 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275011373 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275011374 DNA-binding site [nucleotide binding]; DNA binding site 1144275011375 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275011376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275011377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275011378 DNA binding residues [nucleotide binding] 1144275011379 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1144275011380 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1144275011381 active site 1144275011382 homodimer interface [polypeptide binding]; other site 1144275011383 catalytic site [active] 1144275011384 acceptor binding site [chemical binding]; other site 1144275011385 trehalose synthase; Region: treS_nterm; TIGR02456 1144275011386 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1144275011387 active site 1144275011388 catalytic site [active] 1144275011389 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 1144275011390 glycogen branching enzyme; Provisional; Region: PRK05402 1144275011391 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1144275011392 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1144275011393 active site 1144275011394 catalytic site [active] 1144275011395 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1144275011396 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275011397 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275011398 active site 1144275011399 catalytic tetrad [active] 1144275011400 PilZ domain; Region: PilZ; cl01260 1144275011401 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1144275011402 heme binding pocket [chemical binding]; other site 1144275011403 heme ligand [chemical binding]; other site 1144275011404 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1144275011405 Predicted transcriptional regulators [Transcription]; Region: COG1510 1144275011406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275011407 dimerization interface [polypeptide binding]; other site 1144275011408 putative Zn2+ binding site [ion binding]; other site 1144275011409 putative DNA binding site [nucleotide binding]; other site 1144275011410 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1144275011411 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1144275011412 substrate binding pocket [chemical binding]; other site 1144275011413 chain length determination region; other site 1144275011414 substrate-Mg2+ binding site; other site 1144275011415 catalytic residues [active] 1144275011416 aspartate-rich region 1; other site 1144275011417 active site lid residues [active] 1144275011418 aspartate-rich region 2; other site 1144275011419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275011420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275011421 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275011422 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275011423 dimer interface [polypeptide binding]; other site 1144275011424 putative CheW interface [polypeptide binding]; other site 1144275011425 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1144275011426 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275011427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011428 active site 1144275011429 phosphorylation site [posttranslational modification] 1144275011430 intermolecular recognition site; other site 1144275011431 dimerization interface [polypeptide binding]; other site 1144275011432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275011433 dimer interface [polypeptide binding]; other site 1144275011434 phosphorylation site [posttranslational modification] 1144275011435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275011436 ATP binding site [chemical binding]; other site 1144275011437 Mg2+ binding site [ion binding]; other site 1144275011438 G-X-G motif; other site 1144275011439 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1144275011440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011441 HupE / UreJ protein; Region: HupE_UreJ; cl01011 1144275011442 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1144275011443 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1144275011444 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1144275011445 amidase catalytic site [active] 1144275011446 Zn binding residues [ion binding]; other site 1144275011447 substrate binding site [chemical binding]; other site 1144275011448 Outer membrane efflux protein; Region: OEP; pfam02321 1144275011449 Outer membrane efflux protein; Region: OEP; pfam02321 1144275011450 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275011451 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1144275011452 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1144275011453 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1144275011454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275011455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275011456 Phospholipid methyltransferase; Region: PEMT; cl00763 1144275011457 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275011458 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1144275011459 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1144275011460 GAF domain; Region: GAF; cl15785 1144275011461 GAF domain; Region: GAF_2; pfam13185 1144275011462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275011463 dimer interface [polypeptide binding]; other site 1144275011464 phosphorylation site [posttranslational modification] 1144275011465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275011466 ATP binding site [chemical binding]; other site 1144275011467 Mg2+ binding site [ion binding]; other site 1144275011468 G-X-G motif; other site 1144275011469 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275011470 putative di-iron ligands [ion binding]; other site 1144275011471 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275011472 Bacterial PH domain; Region: DUF304; cl01348 1144275011473 Bacterial PH domain; Region: DUF304; cl01348 1144275011474 Predicted membrane protein [Function unknown]; Region: COG3428 1144275011475 Bacterial PH domain; Region: DUF304; cl01348 1144275011476 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1144275011477 active site 1144275011478 dihydroxyacetone kinase; Provisional; Region: PRK14479 1144275011479 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1144275011480 DAK2 domain; Region: Dak2; cl03685 1144275011481 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1144275011482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275011483 putative substrate translocation pore; other site 1144275011484 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1144275011485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275011486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275011487 catalytic residue [active] 1144275011488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275011489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011490 NAD(P) binding site [chemical binding]; other site 1144275011491 active site 1144275011492 isochorismate synthase DhbC; Validated; Region: PRK06923 1144275011493 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1144275011494 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1144275011495 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011496 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275011497 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1144275011498 Isochorismatase family; Region: Isochorismatase; pfam00857 1144275011499 catalytic triad [active] 1144275011500 conserved cis-peptide bond; other site 1144275011501 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011502 Condensation domain; Region: Condensation; pfam00668 1144275011503 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275011504 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011505 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011506 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011507 thioester reductase domain; Region: Thioester-redct; TIGR01746 1144275011508 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1144275011509 putative NAD(P) binding site [chemical binding]; other site 1144275011510 active site 1144275011511 putative substrate binding site [chemical binding]; other site 1144275011512 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 1144275011513 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275011514 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1144275011515 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275011516 N-terminal plug; other site 1144275011517 ligand-binding site [chemical binding]; other site 1144275011518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275011519 active site 1144275011520 UPF0506; Region: UPF0506; pfam11703 1144275011521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275011522 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275011523 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275011524 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275011525 Walker A/P-loop; other site 1144275011526 ATP binding site [chemical binding]; other site 1144275011527 Q-loop/lid; other site 1144275011528 ABC transporter signature motif; other site 1144275011529 Walker B; other site 1144275011530 D-loop; other site 1144275011531 H-loop/switch region; other site 1144275011532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275011533 FtsX-like permease family; Region: FtsX; cl15850 1144275011534 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275011535 YCII-related domain; Region: YCII; cl00999 1144275011536 peptide synthase; Provisional; Region: PRK12467 1144275011537 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011538 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011539 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011540 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011541 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011542 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011543 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011544 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275011545 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011546 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1144275011547 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275011548 active site 1144275011549 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275011550 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1144275011551 putative NADP binding site [chemical binding]; other site 1144275011552 active site 1144275011553 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011554 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1144275011555 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011556 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011557 peptide synthase; Provisional; Region: PRK12467 1144275011558 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011559 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011560 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011561 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011562 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011563 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011564 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011565 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011566 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1144275011567 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011568 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011569 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275011570 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011571 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011572 acyl-CoA synthetase; Validated; Region: PRK08308 1144275011573 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011574 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1144275011575 Walker A/P-loop; other site 1144275011576 ATP binding site [chemical binding]; other site 1144275011577 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1144275011578 active site 1144275011579 NTP binding site [chemical binding]; other site 1144275011580 metal binding triad [ion binding]; metal-binding site 1144275011581 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1144275011582 Penicillin amidase; Region: Penicil_amidase; pfam01804 1144275011583 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275011584 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275011585 active site 1144275011586 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275011587 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1144275011588 putative active site [active] 1144275011589 putative metal binding site [ion binding]; other site 1144275011590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275011591 HEAT repeats; Region: HEAT_2; pfam13646 1144275011592 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1144275011593 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275011594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275011595 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1144275011596 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1144275011597 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1144275011598 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1144275011599 putative active site [active] 1144275011600 putative metal binding site [ion binding]; other site 1144275011601 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275011602 active site 1144275011603 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275011604 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1144275011605 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1144275011606 active site 1144275011607 TDP-binding site; other site 1144275011608 acceptor substrate-binding pocket; other site 1144275011609 homodimer interface [polypeptide binding]; other site 1144275011610 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275011611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011612 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275011613 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1144275011614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1144275011615 active site 1144275011616 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1144275011617 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1144275011618 active site 1144275011619 TDP-binding site; other site 1144275011620 acceptor substrate-binding pocket; other site 1144275011621 homodimer interface [polypeptide binding]; other site 1144275011622 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1144275011623 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1144275011624 Walker A/P-loop; other site 1144275011625 ATP binding site [chemical binding]; other site 1144275011626 Q-loop/lid; other site 1144275011627 ABC transporter signature motif; other site 1144275011628 Walker B; other site 1144275011629 D-loop; other site 1144275011630 H-loop/switch region; other site 1144275011631 Protein of unknown function DUF91; Region: DUF91; cl00709 1144275011632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275011633 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1144275011634 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1144275011635 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275011636 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275011637 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275011638 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1144275011639 structural tetrad; other site 1144275011640 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275011641 structural tetrad; other site 1144275011642 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1144275011643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275011644 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275011645 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275011646 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275011647 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275011648 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1144275011649 PLD-like domain; Region: PLDc_2; pfam13091 1144275011650 homodimer interface [polypeptide binding]; other site 1144275011651 putative active site [active] 1144275011652 catalytic site [active] 1144275011653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275011654 ATP binding site [chemical binding]; other site 1144275011655 putative Mg++ binding site [ion binding]; other site 1144275011656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275011657 nucleotide binding region [chemical binding]; other site 1144275011658 ATP-binding site [chemical binding]; other site 1144275011659 Domain of unknown function (DUF932); Region: DUF932; cl12129 1144275011660 Domain of unknown function (DUF932); Region: DUF932; cl12129 1144275011661 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1144275011662 catalytic site [active] 1144275011663 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1144275011664 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1144275011665 IHF dimer interface [polypeptide binding]; other site 1144275011666 IHF - DNA interface [nucleotide binding]; other site 1144275011667 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1144275011668 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1144275011669 putative tRNA-binding site [nucleotide binding]; other site 1144275011670 B3/4 domain; Region: B3_4; cl11458 1144275011671 tRNA synthetase B5 domain; Region: B5; cl08394 1144275011672 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1144275011673 dimer interface [polypeptide binding]; other site 1144275011674 motif 1; other site 1144275011675 motif 3; other site 1144275011676 motif 2; other site 1144275011677 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1144275011678 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1144275011679 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1144275011680 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1144275011681 dimer interface [polypeptide binding]; other site 1144275011682 motif 1; other site 1144275011683 active site 1144275011684 motif 2; other site 1144275011685 motif 3; other site 1144275011686 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1144275011687 23S rRNA binding site [nucleotide binding]; other site 1144275011688 L21 binding site [polypeptide binding]; other site 1144275011689 L13 binding site [polypeptide binding]; other site 1144275011690 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1144275011691 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1144275011692 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1144275011693 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1144275011694 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1144275011695 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1144275011696 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1144275011697 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1144275011698 active site 1144275011699 dimer interface [polypeptide binding]; other site 1144275011700 motif 1; other site 1144275011701 motif 2; other site 1144275011702 motif 3; other site 1144275011703 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1144275011704 anticodon binding site; other site 1144275011705 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1144275011706 Fe-S cluster binding site [ion binding]; other site 1144275011707 DNA binding site [nucleotide binding] 1144275011708 active site 1144275011709 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1144275011710 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1144275011711 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275011712 LPP20 lipoprotein; Region: LPP20; cl15824 1144275011713 PilZ domain; Region: PilZ; cl01260 1144275011714 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1144275011715 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1144275011716 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275011717 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275011718 Zn binding site [ion binding]; other site 1144275011719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1144275011720 DNA-binding site [nucleotide binding]; DNA binding site 1144275011721 RNA-binding motif; other site 1144275011722 Angiotensin-converting enzyme; Region: Peptidase_M2; pfam01401 1144275011723 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 1144275011724 active site 1144275011725 Zn binding site [ion binding]; other site 1144275011726 UV-endonuclease UvdE; Region: UvdE; cl10036 1144275011727 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 1144275011728 DHH family; Region: DHH; pfam01368 1144275011729 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1144275011730 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275011731 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011732 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011733 peptide synthase; Provisional; Region: PRK12316 1144275011734 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011735 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011736 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011737 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011738 peptide synthase; Provisional; Region: PRK12316 1144275011739 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011740 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011741 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011742 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011743 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275011744 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275011745 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011746 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011747 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275011748 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1144275011749 dimer interface [polypeptide binding]; other site 1144275011750 substrate binding site [chemical binding]; other site 1144275011751 metal binding site [ion binding]; metal-binding site 1144275011752 von Willebrand factor; Region: vWF_A; pfam12450 1144275011753 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1144275011754 metal ion-dependent adhesion site (MIDAS); other site 1144275011755 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1144275011756 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1144275011757 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1144275011758 Integrase core domain; Region: rve; cl01316 1144275011759 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1144275011760 AAA domain; Region: AAA_22; pfam13401 1144275011761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275011762 Walker A motif; other site 1144275011763 ATP binding site [chemical binding]; other site 1144275011764 Walker B motif; other site 1144275011765 arginine finger; other site 1144275011766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1144275011767 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1144275011768 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1144275011769 active site 1144275011770 DNA binding site [nucleotide binding] 1144275011771 Int/Topo IB signature motif; other site 1144275011772 catalytic residues [active] 1144275011773 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275011774 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275011775 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275011776 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1144275011777 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1144275011778 Helix-turn-helix domains; Region: HTH; cl00088 1144275011779 LysR family transcriptional regulator; Provisional; Region: PRK14997 1144275011780 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1144275011781 putative effector binding pocket; other site 1144275011782 putative dimerization interface [polypeptide binding]; other site 1144275011783 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 1144275011784 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1144275011785 RNA binding site [nucleotide binding]; other site 1144275011786 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275011787 RNA binding site [nucleotide binding]; other site 1144275011788 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1144275011789 RNA binding site [nucleotide binding]; other site 1144275011790 domain interface; other site 1144275011791 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275011792 RNA binding site [nucleotide binding]; other site 1144275011793 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1144275011794 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1144275011795 dinuclear metal binding motif [ion binding]; other site 1144275011796 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1144275011797 Encapsulating protein for peroxidase; Region: Linocin_M18; cl12047 1144275011798 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275011799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275011800 active site 1144275011801 phosphorylation site [posttranslational modification] 1144275011802 intermolecular recognition site; other site 1144275011803 dimerization interface [polypeptide binding]; other site 1144275011804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275011805 Walker A motif; other site 1144275011806 ATP binding site [chemical binding]; other site 1144275011807 Walker B motif; other site 1144275011808 arginine finger; other site 1144275011809 Helix-turn-helix domains; Region: HTH; cl00088 1144275011810 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275011811 Predicted methyltransferases [General function prediction only]; Region: COG0313 1144275011812 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1144275011813 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1144275011814 Restriction endonuclease; Region: Mrr_cat; cl00516 1144275011815 AAA domain; Region: AAA_27; pfam13514 1144275011816 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1144275011817 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1144275011818 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1144275011819 RimM N-terminal domain; Region: RimM; pfam01782 1144275011820 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1144275011821 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1144275011822 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1144275011823 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1144275011824 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1144275011825 radical SAM enzyme, TIGR04100 family; Region: rSAM_pair_X 1144275011826 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1144275011827 FAD binding pocket [chemical binding]; other site 1144275011828 FAD binding motif [chemical binding]; other site 1144275011829 phosphate binding motif [ion binding]; other site 1144275011830 NAD binding pocket [chemical binding]; other site 1144275011831 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1144275011832 active site 1144275011833 multimer interface [polypeptide binding]; other site 1144275011834 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1144275011835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011836 CoA-ligase; Region: Ligase_CoA; cl02894 1144275011837 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1144275011838 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275011839 CoA-ligase; Region: Ligase_CoA; cl02894 1144275011840 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1144275011841 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275011842 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1144275011843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011844 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1144275011845 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1144275011846 malate dehydrogenase; Reviewed; Region: PRK06223 1144275011847 dimer interface [polypeptide binding]; other site 1144275011848 NAD(P) binding site [chemical binding]; other site 1144275011849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1144275011850 substrate binding site [chemical binding]; other site 1144275011851 isocitrate dehydrogenase; Validated; Region: PRK07362 1144275011852 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1144275011853 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1144275011854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275011858 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275011859 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1144275011860 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011861 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011862 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1144275011863 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1144275011864 metal binding site [ion binding]; metal-binding site 1144275011865 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 1144275011866 substrate binding pocket [chemical binding]; other site 1144275011867 UbiA prenyltransferase family; Region: UbiA; cl00337 1144275011868 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1144275011869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275011870 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1144275011871 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1144275011872 dimer interface [polypeptide binding]; other site 1144275011873 tetramer interface [polypeptide binding]; other site 1144275011874 PYR/PP interface [polypeptide binding]; other site 1144275011875 TPP binding site [chemical binding]; other site 1144275011876 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1144275011877 TPP-binding site; other site 1144275011878 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 1144275011879 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1144275011880 NeuB family; Region: NeuB; cl00496 1144275011881 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1144275011882 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1144275011883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275011884 S-adenosylmethionine binding site [chemical binding]; other site 1144275011885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275011886 active site 1144275011887 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1144275011888 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1144275011889 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1144275011890 Tetramer interface [polypeptide binding]; other site 1144275011891 active site 1144275011892 FMN-binding site [chemical binding]; other site 1144275011893 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1144275011894 active site 1144275011895 NAD binding site [chemical binding]; other site 1144275011896 metal binding site [ion binding]; metal-binding site 1144275011897 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 1144275011898 putative active site [active] 1144275011899 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1144275011900 Citrate synthase; Region: Citrate_synt; pfam00285 1144275011901 oxalacetate binding site [chemical binding]; other site 1144275011902 citrylCoA binding site [chemical binding]; other site 1144275011903 coenzyme A binding site [chemical binding]; other site 1144275011904 catalytic triad [active] 1144275011905 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1144275011906 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275011907 Bifunctional nuclease; Region: DNase-RNase; cl00553 1144275011908 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1144275011909 pyruvate kinase; Provisional; Region: PRK05826 1144275011910 domain interfaces; other site 1144275011911 active site 1144275011912 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1144275011913 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1144275011914 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1144275011915 catalytic site [active] 1144275011916 subunit interface [polypeptide binding]; other site 1144275011917 dihydroorotase; Validated; Region: pyrC; PRK09357 1144275011918 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275011919 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1144275011920 active site 1144275011921 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1144275011922 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1144275011923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011924 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 1144275011925 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1144275011926 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1144275011927 Catalytic site [active] 1144275011928 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1144275011929 GTP-binding protein LepA; Provisional; Region: PRK05433 1144275011930 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1144275011931 G1 box; other site 1144275011932 putative GEF interaction site [polypeptide binding]; other site 1144275011933 GTP/Mg2+ binding site [chemical binding]; other site 1144275011934 Switch I region; other site 1144275011935 G2 box; other site 1144275011936 G3 box; other site 1144275011937 Switch II region; other site 1144275011938 G4 box; other site 1144275011939 G5 box; other site 1144275011940 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1144275011941 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1144275011942 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1144275011943 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275011944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275011945 NAD(P) binding site [chemical binding]; other site 1144275011946 active site 1144275011947 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1144275011948 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1144275011949 NAD binding site [chemical binding]; other site 1144275011950 putative substrate binding site 2 [chemical binding]; other site 1144275011951 putative substrate binding site 1 [chemical binding]; other site 1144275011952 active site 1144275011953 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1144275011954 Cupin domain; Region: Cupin_2; cl09118 1144275011955 Sporulation related domain; Region: SPOR; cl10051 1144275011956 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1144275011957 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1144275011958 Ligand Binding Site [chemical binding]; other site 1144275011959 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1144275011960 active site 1144275011961 NTP binding site [chemical binding]; other site 1144275011962 metal binding triad [ion binding]; metal-binding site 1144275011963 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1144275011964 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275011965 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 1144275011966 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275011967 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1144275011968 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1144275011969 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1144275011970 active site 1144275011971 catalytic residues [active] 1144275011972 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1144275011973 hypothetical protein; Provisional; Region: PRK12361 1144275011974 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1144275011975 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275011976 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275011977 active site 1144275011978 catalytic tetrad [active] 1144275011979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275011980 Helix-turn-helix domains; Region: HTH; cl00088 1144275011981 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275011982 putative effector binding pocket; other site 1144275011983 putative dimerization interface [polypeptide binding]; other site 1144275011984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275011985 Helix-turn-helix domains; Region: HTH; cl00088 1144275011986 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275011987 putative effector binding pocket; other site 1144275011988 putative dimerization interface [polypeptide binding]; other site 1144275011989 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1144275011990 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1144275011991 putative NAD(P) binding site [chemical binding]; other site 1144275011992 putative substrate binding site [chemical binding]; other site 1144275011993 catalytic Zn binding site [ion binding]; other site 1144275011994 structural Zn binding site [ion binding]; other site 1144275011995 dimer interface [polypeptide binding]; other site 1144275011996 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1144275011997 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1144275011998 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275011999 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275012000 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275012001 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275012002 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275012003 ligand binding site [chemical binding]; other site 1144275012004 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1144275012005 active site 1144275012006 catalytic residues [active] 1144275012007 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1144275012008 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275012009 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1144275012010 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1144275012011 putative NAD(P) binding site [chemical binding]; other site 1144275012012 putative substrate binding site [chemical binding]; other site 1144275012013 catalytic Zn binding site [ion binding]; other site 1144275012014 structural Zn binding site [ion binding]; other site 1144275012015 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275012016 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1144275012017 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275012018 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275012019 metal binding site [ion binding]; metal-binding site 1144275012020 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 1144275012021 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1144275012022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012023 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1144275012024 Walker B; other site 1144275012025 D-loop; other site 1144275012026 H-loop/switch region; other site 1144275012027 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275012028 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275012029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012030 binding surface 1144275012031 TPR motif; other site 1144275012032 Predicted membrane protein [Function unknown]; Region: COG4425 1144275012033 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1144275012034 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 1144275012035 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1144275012036 Cytochrome c; Region: Cytochrom_C; cl11414 1144275012037 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275012038 classical (c) SDRs; Region: SDR_c; cd05233 1144275012039 NAD(P) binding site [chemical binding]; other site 1144275012040 active site 1144275012041 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275012042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012043 NAD(P) binding site [chemical binding]; other site 1144275012044 active site 1144275012045 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1144275012046 Helix-turn-helix domains; Region: HTH; cl00088 1144275012047 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1144275012048 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275012049 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275012050 active site 1144275012051 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1144275012052 Family description; Region: VCBS; pfam13517 1144275012053 Family description; Region: VCBS; pfam13517 1144275012054 Family description; Region: VCBS; pfam13517 1144275012055 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1144275012056 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1144275012057 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275012058 AAA domain; Region: AAA_28; pfam13521 1144275012059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275012060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275012061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012062 active site 1144275012063 phosphorylation site [posttranslational modification] 1144275012064 intermolecular recognition site; other site 1144275012065 dimerization interface [polypeptide binding]; other site 1144275012066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275012067 DNA binding site [nucleotide binding] 1144275012068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275012069 dimer interface [polypeptide binding]; other site 1144275012070 phosphorylation site [posttranslational modification] 1144275012071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012072 ATP binding site [chemical binding]; other site 1144275012073 Mg2+ binding site [ion binding]; other site 1144275012074 G-X-G motif; other site 1144275012075 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1144275012076 LysR family transcriptional regulator; Provisional; Region: PRK14997 1144275012077 Helix-turn-helix domains; Region: HTH; cl00088 1144275012078 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275012079 putative effector binding pocket; other site 1144275012080 dimerization interface [polypeptide binding]; other site 1144275012081 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275012082 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1144275012083 C-terminal domain interface [polypeptide binding]; other site 1144275012084 GSH binding site (G-site) [chemical binding]; other site 1144275012085 dimer interface [polypeptide binding]; other site 1144275012086 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1144275012087 N-terminal domain interface [polypeptide binding]; other site 1144275012088 dimer interface [polypeptide binding]; other site 1144275012089 substrate binding pocket (H-site) [chemical binding]; other site 1144275012090 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1144275012091 Spore germination protein; Region: Spore_permease; cl15802 1144275012092 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1144275012093 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1144275012094 ATP binding site [chemical binding]; other site 1144275012095 Mg++ binding site [ion binding]; other site 1144275012096 motif III; other site 1144275012097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275012098 nucleotide binding region [chemical binding]; other site 1144275012099 ATP-binding site [chemical binding]; other site 1144275012100 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275012101 ligand binding site [chemical binding]; other site 1144275012102 flexible hinge region; other site 1144275012103 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1144275012104 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 1144275012105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275012106 Helix-turn-helix domains; Region: HTH; cl00088 1144275012107 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1144275012108 putative effector binding pocket; other site 1144275012109 putative dimerization interface [polypeptide binding]; other site 1144275012110 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275012111 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1144275012112 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1144275012113 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1144275012114 putative active site [active] 1144275012115 putative metal binding site [ion binding]; other site 1144275012116 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275012117 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275012118 putative di-iron ligands [ion binding]; other site 1144275012119 Phospholipid methyltransferase; Region: PEMT; cl00763 1144275012120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275012121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275012122 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1144275012123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275012124 putative active site [active] 1144275012125 heme pocket [chemical binding]; other site 1144275012126 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1144275012127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275012128 dimer interface [polypeptide binding]; other site 1144275012129 phosphorylation site [posttranslational modification] 1144275012130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012131 ATP binding site [chemical binding]; other site 1144275012132 Mg2+ binding site [ion binding]; other site 1144275012133 G-X-G motif; other site 1144275012134 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275012135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012136 active site 1144275012137 phosphorylation site [posttranslational modification] 1144275012138 intermolecular recognition site; other site 1144275012139 dimerization interface [polypeptide binding]; other site 1144275012140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275012141 dimer interface [polypeptide binding]; other site 1144275012142 phosphorylation site [posttranslational modification] 1144275012143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012144 ATP binding site [chemical binding]; other site 1144275012145 Mg2+ binding site [ion binding]; other site 1144275012146 G-X-G motif; other site 1144275012147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012148 active site 1144275012149 phosphorylation site [posttranslational modification] 1144275012150 intermolecular recognition site; other site 1144275012151 dimerization interface [polypeptide binding]; other site 1144275012152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275012153 PAS fold; Region: PAS_3; pfam08447 1144275012154 putative active site [active] 1144275012155 heme pocket [chemical binding]; other site 1144275012156 GAF domain; Region: GAF; cl15785 1144275012157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275012158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275012159 dimer interface [polypeptide binding]; other site 1144275012160 phosphorylation site [posttranslational modification] 1144275012161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012162 ATP binding site [chemical binding]; other site 1144275012163 Mg2+ binding site [ion binding]; other site 1144275012164 G-X-G motif; other site 1144275012165 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275012166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012167 active site 1144275012168 phosphorylation site [posttranslational modification] 1144275012169 intermolecular recognition site; other site 1144275012170 dimerization interface [polypeptide binding]; other site 1144275012171 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1144275012172 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1144275012173 peptidase domain interface [polypeptide binding]; other site 1144275012174 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1144275012175 active site 1144275012176 catalytic triad [active] 1144275012177 calcium binding site [ion binding]; other site 1144275012178 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 1144275012179 YcaO-like family; Region: YcaO; pfam02624 1144275012180 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 1144275012181 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275012182 B12 binding site [chemical binding]; other site 1144275012183 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1144275012184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1144275012185 FeS/SAM binding site; other site 1144275012186 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275012187 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1144275012188 putative FMN binding site [chemical binding]; other site 1144275012189 NADPH bind site [chemical binding]; other site 1144275012190 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 1144275012191 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275012192 active site 1144275012193 ATP binding site [chemical binding]; other site 1144275012194 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 1144275012195 substrate binding site [chemical binding]; other site 1144275012196 activation loop (A-loop); other site 1144275012197 cyclase homology domain; Region: CHD; cd07302 1144275012198 dimer interface [polypeptide binding]; other site 1144275012199 nucleotidyl binding site; other site 1144275012200 metal binding site [ion binding]; metal-binding site 1144275012201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012202 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275012203 phosphopeptide binding site; other site 1144275012204 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275012205 GAF domain; Region: GAF; cl15785 1144275012206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275012207 dimer interface [polypeptide binding]; other site 1144275012208 phosphorylation site [posttranslational modification] 1144275012209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012210 ATP binding site [chemical binding]; other site 1144275012211 Mg2+ binding site [ion binding]; other site 1144275012212 G-X-G motif; other site 1144275012213 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1144275012214 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1144275012215 ligand-binding site [chemical binding]; other site 1144275012216 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1144275012217 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1144275012218 CysD dimerization site [polypeptide binding]; other site 1144275012219 G1 box; other site 1144275012220 putative GEF interaction site [polypeptide binding]; other site 1144275012221 GTP/Mg2+ binding site [chemical binding]; other site 1144275012222 Switch I region; other site 1144275012223 G2 box; other site 1144275012224 G3 box; other site 1144275012225 Switch II region; other site 1144275012226 G4 box; other site 1144275012227 G5 box; other site 1144275012228 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1144275012229 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1144275012230 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1144275012231 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1144275012232 Active Sites [active] 1144275012233 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1144275012234 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1144275012235 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1144275012236 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1144275012237 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1144275012238 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1144275012239 DXD motif; other site 1144275012240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275012241 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1144275012242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012243 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1144275012244 allantoinase; Region: allantoinase; TIGR03178 1144275012245 active site 1144275012246 allantoicase; Provisional; Region: PRK13257 1144275012247 Allantoicase repeat; Region: Allantoicase; pfam03561 1144275012248 Allantoicase repeat; Region: Allantoicase; pfam03561 1144275012249 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1144275012250 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1144275012251 active site 1144275012252 homotetramer interface [polypeptide binding]; other site 1144275012253 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275012254 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1144275012255 iron-sulfur cluster [ion binding]; other site 1144275012256 [2Fe-2S] cluster binding site [ion binding]; other site 1144275012257 Integral membrane protein TerC family; Region: TerC; cl10468 1144275012258 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 1144275012259 SCP-2 sterol transfer family; Region: SCP2; cl01225 1144275012260 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275012261 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1144275012262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012263 Family description; Region: UvrD_C_2; cl15862 1144275012264 HEAT repeats; Region: HEAT_2; pfam13646 1144275012265 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1144275012266 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1144275012267 DXD motif; other site 1144275012268 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1144275012269 aspartate kinase; Reviewed; Region: PRK06635 1144275012270 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1144275012271 putative nucleotide binding site [chemical binding]; other site 1144275012272 putative catalytic residues [active] 1144275012273 putative Mg ion binding site [ion binding]; other site 1144275012274 putative aspartate binding site [chemical binding]; other site 1144275012275 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1144275012276 putative allosteric regulatory site; other site 1144275012277 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1144275012278 putative allosteric regulatory residue; other site 1144275012279 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1144275012280 active sites [active] 1144275012281 tetramer interface [polypeptide binding]; other site 1144275012282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012283 active site 1144275012284 phosphorylation site [posttranslational modification] 1144275012285 intermolecular recognition site; other site 1144275012286 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275012287 DDE superfamily endonuclease; Region: DDE_5; cl02413 1144275012288 DDE superfamily endonuclease; Region: DDE_5; cl02413 1144275012289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012290 TPR motif; other site 1144275012291 binding surface 1144275012292 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275012293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012294 binding surface 1144275012295 TPR motif; other site 1144275012296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012297 TPR motif; other site 1144275012298 binding surface 1144275012299 TPR repeat; Region: TPR_11; pfam13414 1144275012300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275012301 binding surface 1144275012302 TPR motif; other site 1144275012303 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1144275012304 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1144275012305 MPT binding site; other site 1144275012306 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275012307 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275012308 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275012309 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1144275012310 NAD(P) binding site [chemical binding]; other site 1144275012311 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275012312 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275012313 active site 1144275012314 catalytic tetrad [active] 1144275012315 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275012316 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275012317 active site 1144275012318 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1144275012319 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275012320 active site 1144275012321 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1144275012322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275012323 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1144275012324 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275012325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275012326 catalytic residue [active] 1144275012327 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1144275012328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012329 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1144275012330 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; cl14733 1144275012331 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275012332 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 1144275012333 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1144275012334 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275012335 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275012336 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275012337 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275012338 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275012339 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1144275012340 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275012341 AMP-binding domain protein; Validated; Region: PRK08315 1144275012342 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275012343 thymidylate kinase; Validated; Region: tmk; PRK00698 1144275012344 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1144275012345 TMP-binding site; other site 1144275012346 ATP-binding site [chemical binding]; other site 1144275012347 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1144275012348 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1144275012349 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1144275012350 dimerization interface [polypeptide binding]; other site 1144275012351 active site 1144275012352 threonine synthase; Validated; Region: PRK06260 1144275012353 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1144275012354 homodimer interface [polypeptide binding]; other site 1144275012355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275012356 catalytic residue [active] 1144275012357 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1144275012358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275012359 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1144275012360 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1144275012361 ssDNA binding site; other site 1144275012362 generic binding surface II; other site 1144275012363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275012364 ATP binding site [chemical binding]; other site 1144275012365 putative Mg++ binding site [ion binding]; other site 1144275012366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275012367 nucleotide binding region [chemical binding]; other site 1144275012368 ATP-binding site [chemical binding]; other site 1144275012369 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1144275012370 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1144275012371 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275012372 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275012373 phosphopeptide binding site; other site 1144275012374 Putative zinc-finger; Region: zf-HC2; cl15806 1144275012375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012376 binding surface 1144275012377 TPR motif; other site 1144275012378 CHAT domain; Region: CHAT; pfam12770 1144275012379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275012380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275012381 DNA binding residues [nucleotide binding] 1144275012382 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1144275012383 Transcriptional regulator; Region: Transcrip_reg; cl00361 1144275012384 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275012385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275012386 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275012387 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1144275012388 DNA binding site [nucleotide binding] 1144275012389 active site 1144275012390 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1144275012391 PAS domain S-box; Region: sensory_box; TIGR00229 1144275012392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275012393 putative active site [active] 1144275012394 heme pocket [chemical binding]; other site 1144275012395 PAS fold; Region: PAS_4; pfam08448 1144275012396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275012397 putative active site [active] 1144275012398 heme pocket [chemical binding]; other site 1144275012399 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275012400 GAF domain; Region: GAF; cl15785 1144275012401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275012402 dimer interface [polypeptide binding]; other site 1144275012403 phosphorylation site [posttranslational modification] 1144275012404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012405 ATP binding site [chemical binding]; other site 1144275012406 Mg2+ binding site [ion binding]; other site 1144275012407 G-X-G motif; other site 1144275012408 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275012409 active site 1144275012410 ATP binding site [chemical binding]; other site 1144275012411 substrate binding site [chemical binding]; other site 1144275012412 activation loop (A-loop); other site 1144275012413 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1144275012414 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 1144275012415 putative homodimer interface [polypeptide binding]; other site 1144275012416 putative active site [active] 1144275012417 catalytic site [active] 1144275012418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275012420 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1144275012421 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1144275012422 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1144275012423 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1144275012424 conserved hypothetical protein; Region: TIGR02231 1144275012425 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1144275012426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275012427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012428 hypothetical protein; Provisional; Region: PRK06753 1144275012429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275012430 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1144275012431 active site 1144275012432 FMN binding site [chemical binding]; other site 1144275012433 substrate binding site [chemical binding]; other site 1144275012434 homotetramer interface [polypeptide binding]; other site 1144275012435 catalytic residue [active] 1144275012436 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1144275012437 active site 1144275012438 catalytic residues [active] 1144275012439 metal binding site [ion binding]; metal-binding site 1144275012440 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275012441 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1144275012442 putative di-iron ligands [ion binding]; other site 1144275012443 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1144275012444 putative active site [active] 1144275012445 putative catalytic site [active] 1144275012446 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275012447 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275012448 Cytochrome c; Region: Cytochrom_C; cl11414 1144275012449 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1144275012450 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 1144275012451 UbiA prenyltransferase family; Region: UbiA; cl00337 1144275012452 replication factor A; Reviewed; Region: PRK12366 1144275012453 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275012454 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275012455 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275012456 catalytic residue [active] 1144275012457 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275012458 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275012459 metal binding site [ion binding]; metal-binding site 1144275012460 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275012461 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275012462 putative di-iron ligands [ion binding]; other site 1144275012463 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1144275012464 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1144275012465 Phosphate transporter family; Region: PHO4; cl00396 1144275012466 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1144275012467 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275012468 B12 binding site [chemical binding]; other site 1144275012469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275012470 FeS/SAM binding site; other site 1144275012471 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275012472 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275012473 Di-iron ligands [ion binding]; other site 1144275012474 cyclase homology domain; Region: CHD; cd07302 1144275012475 nucleotidyl binding site; other site 1144275012476 metal binding site [ion binding]; metal-binding site 1144275012477 dimer interface [polypeptide binding]; other site 1144275012478 cyclase homology domain; Region: CHD; cd07302 1144275012479 nucleotidyl binding site; other site 1144275012480 dimer interface [polypeptide binding]; other site 1144275012481 metal binding site [ion binding]; metal-binding site 1144275012482 Predicted ATPase [General function prediction only]; Region: COG3899 1144275012483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275012485 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1144275012486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275012487 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275012488 active site 1144275012489 ATP binding site [chemical binding]; other site 1144275012490 substrate binding site [chemical binding]; other site 1144275012491 activation loop (A-loop); other site 1144275012492 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1144275012493 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275012494 N-terminal plug; other site 1144275012495 ligand-binding site [chemical binding]; other site 1144275012496 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1144275012497 Ribosomal protein S12-like family; composed of prokaryotic 30S ribosomal protein S12, eukaryotic 40S ribosomal protein S23 and similar proteins. S12 and S23 are located at the interface of the large and small ribosomal subunits, adjacent to the decoding...; Region: Ribosomal_S12_like; cl00312 1144275012498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275012499 TPR motif; other site 1144275012500 binding surface 1144275012501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012502 binding surface 1144275012503 TPR motif; other site 1144275012504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012505 TPR motif; other site 1144275012506 binding surface 1144275012507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012508 TPR motif; other site 1144275012509 binding surface 1144275012510 TPR repeat; Region: TPR_11; pfam13414 1144275012511 TPR repeat; Region: TPR_11; pfam13414 1144275012512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275012513 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1144275012514 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1144275012515 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1144275012516 tetramer interface [polypeptide binding]; other site 1144275012517 TPP-binding site [chemical binding]; other site 1144275012518 heterodimer interface [polypeptide binding]; other site 1144275012519 phosphorylation loop region [posttranslational modification] 1144275012520 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1144275012521 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1144275012522 PYR/PP interface [polypeptide binding]; other site 1144275012523 dimer interface [polypeptide binding]; other site 1144275012524 TPP binding site [chemical binding]; other site 1144275012525 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1144275012526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275012527 Coenzyme A binding pocket [chemical binding]; other site 1144275012528 PilZ domain; Region: PilZ; cl01260 1144275012529 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1144275012530 active site 1144275012531 catalytic triad [active] 1144275012532 oxyanion hole [active] 1144275012533 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1144275012534 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1144275012535 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1144275012536 CotH protein; Region: CotH; pfam08757 1144275012537 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1144275012538 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 1144275012539 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1144275012540 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1144275012541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275012542 PAS fold; Region: PAS_3; pfam08447 1144275012543 putative active site [active] 1144275012544 heme pocket [chemical binding]; other site 1144275012545 GAF domain; Region: GAF; cl15785 1144275012546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275012547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012548 ATP binding site [chemical binding]; other site 1144275012549 Mg2+ binding site [ion binding]; other site 1144275012550 G-X-G motif; other site 1144275012551 YceG-like family; Region: YceG; pfam02618 1144275012552 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1144275012553 dimerization interface [polypeptide binding]; other site 1144275012554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275012555 Helix-turn-helix domains; Region: HTH; cl00088 1144275012556 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1144275012557 putative dimerization interface [polypeptide binding]; other site 1144275012558 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1144275012559 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1144275012560 active site 1144275012561 Helix-turn-helix domains; Region: HTH; cl00088 1144275012562 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1144275012563 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275012564 ATP binding site [chemical binding]; other site 1144275012565 putative Mg++ binding site [ion binding]; other site 1144275012566 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012567 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1144275012568 Domain of unknown function (DUF305); Region: DUF305; cl15795 1144275012569 Domain of unknown function (DUF305); Region: DUF305; cl15795 1144275012570 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275012571 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275012572 active site 1144275012573 ATP binding site [chemical binding]; other site 1144275012574 substrate binding site [chemical binding]; other site 1144275012575 activation loop (A-loop); other site 1144275012576 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1144275012577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012578 CoA-ligase; Region: Ligase_CoA; cl02894 1144275012579 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275012580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275012581 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 1144275012582 NmrA-like family; Region: NmrA; pfam05368 1144275012583 putative NADP binding site [chemical binding]; other site 1144275012584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275012585 Helix-turn-helix domains; Region: HTH; cl00088 1144275012586 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1144275012587 dimerization interface [polypeptide binding]; other site 1144275012588 substrate binding pocket [chemical binding]; other site 1144275012589 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275012590 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1144275012591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275012592 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275012593 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012594 kelch-like protein; Provisional; Region: PHA03098 1144275012595 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012596 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1144275012597 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012598 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012599 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012600 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012601 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012602 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012603 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275012604 ligand binding site [chemical binding]; other site 1144275012605 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275012606 maltose O-acetyltransferase; Provisional; Region: PRK10092 1144275012607 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1144275012608 active site 1144275012609 substrate binding site [chemical binding]; other site 1144275012610 trimer interface [polypeptide binding]; other site 1144275012611 CoA binding site [chemical binding]; other site 1144275012612 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1144275012613 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1144275012614 hypothetical protein; Validated; Region: PRK07883 1144275012615 GIY-YIG motif/motif A; other site 1144275012616 active site 1144275012617 catalytic site [active] 1144275012618 putative DNA binding site [nucleotide binding]; other site 1144275012619 metal binding site [ion binding]; metal-binding site 1144275012620 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275012621 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1144275012622 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1144275012623 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1144275012624 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275012625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275012626 Walker A/P-loop; other site 1144275012627 ATP binding site [chemical binding]; other site 1144275012628 Q-loop/lid; other site 1144275012629 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275012630 ABC transporter signature motif; other site 1144275012631 Walker B; other site 1144275012632 D-loop; other site 1144275012633 ABC transporter; Region: ABC_tran_2; pfam12848 1144275012634 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275012635 Integrase core domain; Region: rve; cl01316 1144275012636 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275012637 Integrase core domain; Region: rve; cl01316 1144275012638 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275012639 active site 1144275012640 ATP binding site [chemical binding]; other site 1144275012641 substrate binding site [chemical binding]; other site 1144275012642 activation loop (A-loop); other site 1144275012643 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1144275012644 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275012645 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275012646 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1144275012647 C-terminal domain interface [polypeptide binding]; other site 1144275012648 GSH binding site (G-site) [chemical binding]; other site 1144275012649 dimer interface [polypeptide binding]; other site 1144275012650 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1144275012651 N-terminal domain interface [polypeptide binding]; other site 1144275012652 dimer interface [polypeptide binding]; other site 1144275012653 substrate binding pocket (H-site) [chemical binding]; other site 1144275012654 Helix-turn-helix domains; Region: HTH; cl00088 1144275012655 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1144275012656 Cupin domain; Region: Cupin_2; cl09118 1144275012657 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1144275012658 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1144275012659 substrate binding site; other site 1144275012660 tetramer interface; other site 1144275012661 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1144275012662 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1144275012663 NADP binding site [chemical binding]; other site 1144275012664 active site 1144275012665 putative substrate binding site [chemical binding]; other site 1144275012666 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1144275012667 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1144275012668 NAD binding site [chemical binding]; other site 1144275012669 substrate binding site [chemical binding]; other site 1144275012670 homodimer interface [polypeptide binding]; other site 1144275012671 active site 1144275012672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275012673 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275012674 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1144275012675 Ligand binding site; other site 1144275012676 Putative Catalytic site; other site 1144275012677 DXD motif; other site 1144275012678 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1144275012679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275012680 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275012681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275012682 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1144275012683 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1144275012684 Probable Catalytic site; other site 1144275012685 metal-binding site 1144275012686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275012687 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1144275012688 Probable Catalytic site; other site 1144275012689 metal-binding site 1144275012690 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1144275012691 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1144275012692 Walker A/P-loop; other site 1144275012693 ATP binding site [chemical binding]; other site 1144275012694 Q-loop/lid; other site 1144275012695 ABC transporter signature motif; other site 1144275012696 Walker B; other site 1144275012697 D-loop; other site 1144275012698 H-loop/switch region; other site 1144275012699 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1144275012700 putative carbohydrate binding site [chemical binding]; other site 1144275012701 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275012702 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1144275012703 TPR repeat; Region: TPR_11; pfam13414 1144275012704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012705 binding surface 1144275012706 TPR motif; other site 1144275012707 TPR repeat; Region: TPR_11; pfam13414 1144275012708 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1144275012709 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1144275012710 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275012711 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275012712 catalytic residue [active] 1144275012713 L-aspartate oxidase; Provisional; Region: PRK09077 1144275012714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012715 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1144275012716 Rhomboid family; Region: Rhomboid; cl11446 1144275012717 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1144275012718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1144275012719 active site 1144275012720 ParB-like nuclease domain; Region: ParBc; cl02129 1144275012721 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1144275012722 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1144275012723 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1144275012724 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1144275012725 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275012726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012727 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275012728 TPR motif; other site 1144275012729 binding surface 1144275012730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012731 binding surface 1144275012732 TPR motif; other site 1144275012733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012734 binding surface 1144275012735 TPR motif; other site 1144275012736 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275012737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275012738 binding surface 1144275012739 TPR motif; other site 1144275012740 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275012741 GAF domain; Region: GAF; cl15785 1144275012742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275012743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012744 ATP binding site [chemical binding]; other site 1144275012745 Mg2+ binding site [ion binding]; other site 1144275012746 G-X-G motif; other site 1144275012747 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275012748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012749 active site 1144275012750 phosphorylation site [posttranslational modification] 1144275012751 intermolecular recognition site; other site 1144275012752 dimerization interface [polypeptide binding]; other site 1144275012753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275012754 metal binding site [ion binding]; metal-binding site 1144275012755 I-site; other site 1144275012756 active site 1144275012757 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1144275012758 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1144275012759 RNA binding surface [nucleotide binding]; other site 1144275012760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275012761 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1144275012762 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1144275012763 TPP-binding site; other site 1144275012764 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1144275012765 PYR/PP interface [polypeptide binding]; other site 1144275012766 dimer interface [polypeptide binding]; other site 1144275012767 TPP binding site [chemical binding]; other site 1144275012768 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1144275012769 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1144275012770 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1144275012771 substrate binding pocket [chemical binding]; other site 1144275012772 chain length determination region; other site 1144275012773 substrate-Mg2+ binding site; other site 1144275012774 catalytic residues [active] 1144275012775 aspartate-rich region 1; other site 1144275012776 active site lid residues [active] 1144275012777 aspartate-rich region 2; other site 1144275012778 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275012779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012780 active site 1144275012781 phosphorylation site [posttranslational modification] 1144275012782 intermolecular recognition site; other site 1144275012783 dimerization interface [polypeptide binding]; other site 1144275012784 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1144275012785 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1144275012786 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1144275012787 generic binding surface II; other site 1144275012788 generic binding surface I; other site 1144275012789 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275012790 phosphopeptide binding site; other site 1144275012791 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275012792 phosphopeptide binding site; other site 1144275012793 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1144275012794 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1144275012795 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1144275012796 Putative zinc-finger; Region: zf-HC2; cl15806 1144275012797 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275012798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275012799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275012800 DNA binding residues [nucleotide binding] 1144275012801 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1144275012802 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1144275012803 Walker A/P-loop; other site 1144275012804 ATP binding site [chemical binding]; other site 1144275012805 Q-loop/lid; other site 1144275012806 ABC transporter signature motif; other site 1144275012807 Walker B; other site 1144275012808 D-loop; other site 1144275012809 H-loop/switch region; other site 1144275012810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1144275012811 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1144275012812 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1144275012813 Walker A/P-loop; other site 1144275012814 ATP binding site [chemical binding]; other site 1144275012815 Q-loop/lid; other site 1144275012816 ABC transporter signature motif; other site 1144275012817 Walker B; other site 1144275012818 D-loop; other site 1144275012819 H-loop/switch region; other site 1144275012820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1144275012821 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275012822 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 1144275012823 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275012824 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 1144275012825 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275012826 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275012827 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275012828 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275012829 active site 1144275012830 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1144275012831 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1144275012832 active site 1144275012833 catalytic site [active] 1144275012834 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1144275012835 active site 1144275012836 catalytic site [active] 1144275012837 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1144275012838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012839 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1144275012840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012841 active site 1144275012842 phosphorylation site [posttranslational modification] 1144275012843 intermolecular recognition site; other site 1144275012844 dimerization interface [polypeptide binding]; other site 1144275012845 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275012846 Zn2+ binding site [ion binding]; other site 1144275012847 Mg2+ binding site [ion binding]; other site 1144275012848 HEAT repeats; Region: HEAT_2; pfam13646 1144275012849 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1144275012850 active site 1144275012851 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275012852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275012853 Walker A motif; other site 1144275012854 ATP binding site [chemical binding]; other site 1144275012855 Walker B motif; other site 1144275012856 arginine finger; other site 1144275012857 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1144275012858 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275012859 metal ion-dependent adhesion site (MIDAS); other site 1144275012860 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1144275012861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275012862 ATP binding site [chemical binding]; other site 1144275012863 putative Mg++ binding site [ion binding]; other site 1144275012864 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1144275012865 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275012866 nucleotide binding region [chemical binding]; other site 1144275012867 ATP-binding site [chemical binding]; other site 1144275012868 Smr domain; Region: Smr; cl02619 1144275012869 Protein of unknown function DUF72; Region: DUF72; cl00777 1144275012870 PAS domain; Region: PAS_9; pfam13426 1144275012871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275012872 DNA binding residues [nucleotide binding] 1144275012873 dimerization interface [polypeptide binding]; other site 1144275012874 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1144275012875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275012876 putative binding surface; other site 1144275012877 active site 1144275012878 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1144275012879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275012880 ATP binding site [chemical binding]; other site 1144275012881 Mg2+ binding site [ion binding]; other site 1144275012882 G-X-G motif; other site 1144275012883 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275012884 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275012885 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275012886 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1144275012887 apolar tunnel; other site 1144275012888 heme binding site [chemical binding]; other site 1144275012889 dimerization interface [polypeptide binding]; other site 1144275012890 hypothetical protein; Provisional; Region: PRK13560 1144275012891 PAS fold; Region: PAS; pfam00989 1144275012892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275012893 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275012894 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275012895 dimer interface [polypeptide binding]; other site 1144275012896 putative CheW interface [polypeptide binding]; other site 1144275012897 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275012898 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1144275012899 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1144275012900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275012901 active site 1144275012902 phosphorylation site [posttranslational modification] 1144275012903 intermolecular recognition site; other site 1144275012904 dimerization interface [polypeptide binding]; other site 1144275012905 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275012906 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1144275012907 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1144275012908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275012909 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1144275012910 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1144275012911 Fic/DOC family; Region: Fic; cl00960 1144275012912 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1144275012913 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1144275012914 putative dimer interface [polypeptide binding]; other site 1144275012915 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1144275012916 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1144275012917 Protein of unknown function, DUF481; Region: DUF481; cl01213 1144275012918 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275012919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275012920 DNA-binding site [nucleotide binding]; DNA binding site 1144275012921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275012922 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1144275012923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275012924 putative DNA binding site [nucleotide binding]; other site 1144275012925 dimerization interface [polypeptide binding]; other site 1144275012926 putative Zn2+ binding site [ion binding]; other site 1144275012927 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275012928 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1144275012929 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1144275012930 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1144275012931 Zn binding site [ion binding]; other site 1144275012932 REJ domain; Region: REJ; pfam02010 1144275012933 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012934 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012935 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012936 kelch-like protein; Provisional; Region: PHA03098 1144275012937 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275012938 short chain dehydrogenase; Provisional; Region: PRK08278 1144275012939 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1144275012940 NAD(P) binding site [chemical binding]; other site 1144275012941 homodimer interface [polypeptide binding]; other site 1144275012942 active site 1144275012943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275012944 Helix-turn-helix domains; Region: HTH; cl00088 1144275012945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1144275012946 dimerization interface [polypeptide binding]; other site 1144275012947 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1144275012948 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1144275012949 cofactor binding site; other site 1144275012950 metal binding site [ion binding]; metal-binding site 1144275012951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275012952 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1144275012953 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275012954 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472 1144275012955 major vault protein; Provisional; Region: PTZ00491 1144275012956 Major Vault Protein repeat; Region: Vault; pfam01505 1144275012957 Major Vault Protein repeat; Region: Vault; pfam01505 1144275012958 Shoulder domain; Region: MVP_shoulder; pfam11978 1144275012959 Putative exonuclease, RdgC; Region: RdgC; cl01122 1144275012960 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1144275012961 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275012962 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1144275012963 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275012964 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1144275012965 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1144275012966 dimer interface [polypeptide binding]; other site 1144275012967 active site 1144275012968 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275012969 substrate binding site [chemical binding]; other site 1144275012970 catalytic residue [active] 1144275012971 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275012972 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl16918 1144275012973 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275012974 ligand binding site [chemical binding]; other site 1144275012975 flexible hinge region; other site 1144275012976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275012977 ligand binding site [chemical binding]; other site 1144275012978 flexible hinge region; other site 1144275012979 Predicted membrane protein [Function unknown]; Region: COG4270 1144275012980 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1144275012981 nudix motif; other site 1144275012982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1144275012983 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1144275012984 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1144275012985 MbtH-like protein; Region: MbtH; cl01279 1144275012986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275012987 active site 1144275012988 phosphorylation site [posttranslational modification] 1144275012989 intermolecular recognition site; other site 1144275012990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275012991 DNA binding residues [nucleotide binding] 1144275012992 dimerization interface [polypeptide binding]; other site 1144275012993 RDD family; Region: RDD; cl00746 1144275012994 Integral membrane protein DUF95; Region: DUF95; cl00572 1144275012995 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275012996 HSP70 interaction site [polypeptide binding]; other site 1144275012997 DivIVA protein; Region: DivIVA; pfam05103 1144275012998 DivIVA domain; Region: DivI1A_domain; TIGR03544 1144275012999 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1144275013000 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275013001 DNA polymerase I; Provisional; Region: PRK05755 1144275013002 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1144275013003 active site 1144275013004 metal binding site 1 [ion binding]; metal-binding site 1144275013005 putative 5' ssDNA interaction site; other site 1144275013006 metal binding site 3; metal-binding site 1144275013007 metal binding site 2 [ion binding]; metal-binding site 1144275013008 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1144275013009 putative DNA binding site [nucleotide binding]; other site 1144275013010 putative metal binding site [ion binding]; other site 1144275013011 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1144275013012 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1144275013013 active site 1144275013014 DNA binding site [nucleotide binding] 1144275013015 catalytic site [active] 1144275013016 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275013017 phosphopeptide binding site; other site 1144275013018 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275013019 phosphopeptide binding site; other site 1144275013020 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275013021 phosphopeptide binding site; other site 1144275013022 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1144275013023 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1144275013024 ATP binding site [chemical binding]; other site 1144275013025 Walker A motif; other site 1144275013026 hexamer interface [polypeptide binding]; other site 1144275013027 Walker B motif; other site 1144275013028 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1144275013029 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1144275013030 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1144275013031 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275013032 phosphopeptide binding site; other site 1144275013033 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1144275013034 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1144275013035 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1144275013036 dimer interface [polypeptide binding]; other site 1144275013037 motif 1; other site 1144275013038 active site 1144275013039 motif 2; other site 1144275013040 motif 3; other site 1144275013041 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275013042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275013043 active site 1144275013044 ATP binding site [chemical binding]; other site 1144275013045 substrate binding site [chemical binding]; other site 1144275013046 activation loop (A-loop); other site 1144275013047 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275013048 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1144275013049 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1144275013050 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1144275013051 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1144275013052 putative substrate binding site [chemical binding]; other site 1144275013053 putative ATP binding site [chemical binding]; other site 1144275013054 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1144275013055 Recombination protein O N terminal; Region: RecO_N; cl15812 1144275013056 Recombination protein O C terminal; Region: RecO_C; pfam02565 1144275013057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275013058 TPR repeat; Region: TPR_11; pfam13414 1144275013059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275013060 binding surface 1144275013061 TPR motif; other site 1144275013062 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275013063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275013064 binding surface 1144275013065 TPR motif; other site 1144275013066 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275013067 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275013068 catalytic residue [active] 1144275013069 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1144275013070 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1144275013071 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1144275013072 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1144275013073 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1144275013074 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1144275013075 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1144275013076 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1144275013077 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1144275013078 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 1144275013079 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1144275013080 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1144275013081 DNA binding site [nucleotide binding] 1144275013082 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1144275013083 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1144275013084 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1144275013085 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1144275013086 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1144275013087 RPB12 interaction site [polypeptide binding]; other site 1144275013088 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1144275013089 RPB11 interaction site [polypeptide binding]; other site 1144275013090 RPB12 interaction site [polypeptide binding]; other site 1144275013091 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1144275013092 RPB3 interaction site [polypeptide binding]; other site 1144275013093 RPB1 interaction site [polypeptide binding]; other site 1144275013094 RPB11 interaction site [polypeptide binding]; other site 1144275013095 RPB10 interaction site [polypeptide binding]; other site 1144275013096 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1144275013097 core dimer interface [polypeptide binding]; other site 1144275013098 peripheral dimer interface [polypeptide binding]; other site 1144275013099 L10 interface [polypeptide binding]; other site 1144275013100 L11 interface [polypeptide binding]; other site 1144275013101 putative EF-Tu interaction site [polypeptide binding]; other site 1144275013102 putative EF-G interaction site [polypeptide binding]; other site 1144275013103 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1144275013104 23S rRNA interface [nucleotide binding]; other site 1144275013105 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1144275013106 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1144275013107 mRNA/rRNA interface [nucleotide binding]; other site 1144275013108 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1144275013109 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1144275013110 23S rRNA interface [nucleotide binding]; other site 1144275013111 L7/L12 interface [polypeptide binding]; other site 1144275013112 putative thiostrepton binding site; other site 1144275013113 L25 interface [polypeptide binding]; other site 1144275013114 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1144275013115 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1144275013116 putative homodimer interface [polypeptide binding]; other site 1144275013117 KOW motif; Region: KOW; cl00354 1144275013118 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1144275013119 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1144275013120 elongation factor Tu; Reviewed; Region: PRK00049 1144275013121 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1144275013122 G1 box; other site 1144275013123 GEF interaction site [polypeptide binding]; other site 1144275013124 GTP/Mg2+ binding site [chemical binding]; other site 1144275013125 Switch I region; other site 1144275013126 G2 box; other site 1144275013127 G3 box; other site 1144275013128 Switch II region; other site 1144275013129 G4 box; other site 1144275013130 G5 box; other site 1144275013131 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1144275013132 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1144275013133 Antibiotic Binding Site [chemical binding]; other site 1144275013134 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1144275013135 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1144275013136 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1144275013137 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1144275013138 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275013139 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275013140 DsrE/DsrF-like family; Region: DrsE; cl00672 1144275013141 HEAT repeats; Region: HEAT_2; pfam13646 1144275013142 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1144275013143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275013144 motif II; other site 1144275013145 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1144275013146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275013147 ATP binding site [chemical binding]; other site 1144275013148 putative Mg++ binding site [ion binding]; other site 1144275013149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275013150 nucleotide binding region [chemical binding]; other site 1144275013151 Helicase associated domain (HA2); Region: HA2; cl04503 1144275013152 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1144275013153 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275013154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275013155 Coenzyme A binding pocket [chemical binding]; other site 1144275013156 Ferredoxin [Energy production and conversion]; Region: COG1146 1144275013157 4Fe-4S binding domain; Region: Fer4; cl02805 1144275013158 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1144275013159 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 1144275013160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013161 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1144275013162 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1144275013163 active site residue [active] 1144275013164 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275013165 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275013166 active site 1144275013167 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1144275013168 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275013169 Stage II sporulation protein; Region: SpoIID; pfam08486 1144275013170 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1144275013171 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275013172 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1144275013173 Cation efflux family; Region: Cation_efflux; cl00316 1144275013174 glycine dehydrogenase; Provisional; Region: PRK05367 1144275013175 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1144275013176 tetramer interface [polypeptide binding]; other site 1144275013177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275013178 catalytic residue [active] 1144275013179 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1144275013180 tetramer interface [polypeptide binding]; other site 1144275013181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275013182 catalytic residue [active] 1144275013183 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1144275013184 lipoyl attachment site [posttranslational modification]; other site 1144275013185 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1144275013186 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1144275013187 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1144275013188 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 1144275013189 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1144275013190 FAD binding site [chemical binding]; other site 1144275013191 homoserine dehydrogenase; Provisional; Region: PRK06270 1144275013192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013193 NAD(P) binding pocket [chemical binding]; other site 1144275013194 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1144275013195 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1144275013196 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275013197 ligand binding site [chemical binding]; other site 1144275013198 O-Antigen ligase; Region: Wzy_C; cl04850 1144275013199 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1144275013200 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1144275013201 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1144275013202 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1144275013203 Transglycosylase; Region: Transgly; cl07896 1144275013204 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1144275013205 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1144275013206 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1144275013207 homodimer interface [polypeptide binding]; other site 1144275013208 NADP binding site [chemical binding]; other site 1144275013209 substrate binding site [chemical binding]; other site 1144275013210 tellurium resistance terB-like protein; Region: terB_like; cl11965 1144275013211 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275013212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1144275013213 Smr domain; Region: Smr; cl02619 1144275013214 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275013215 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1144275013216 active site 1144275013217 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1144275013218 quinone interaction residues [chemical binding]; other site 1144275013219 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 1144275013220 active site 1144275013221 catalytic residues [active] 1144275013222 FMN binding site [chemical binding]; other site 1144275013223 substrate binding site [chemical binding]; other site 1144275013224 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1144275013225 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275013226 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275013227 active site 1144275013228 ATP binding site [chemical binding]; other site 1144275013229 substrate binding site [chemical binding]; other site 1144275013230 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013231 substrate binding site [chemical binding]; other site 1144275013232 activation loop (A-loop); other site 1144275013233 activation loop (A-loop); other site 1144275013234 Protein kinase domain; Region: Pkinase; pfam00069 1144275013235 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275013236 active site 1144275013237 ATP binding site [chemical binding]; other site 1144275013238 substrate binding site [chemical binding]; other site 1144275013239 activation loop (A-loop); other site 1144275013240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013241 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275013242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275013243 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275013244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275013245 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275013246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275013247 alanine dehydrogenase; Validated; Region: PRK06046 1144275013248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013249 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275013250 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275013251 O-Antigen ligase; Region: Wzy_C; cl04850 1144275013252 Predicted GTPase [General function prediction only]; Region: COG0218 1144275013253 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1144275013254 G1 box; other site 1144275013255 GTP/Mg2+ binding site [chemical binding]; other site 1144275013256 Switch I region; other site 1144275013257 G2 box; other site 1144275013258 G3 box; other site 1144275013259 Switch II region; other site 1144275013260 G4 box; other site 1144275013261 G5 box; other site 1144275013262 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1144275013263 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1144275013264 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1144275013265 CoA-binding site [chemical binding]; other site 1144275013266 ATP-binding [chemical binding]; other site 1144275013267 thioester reductase domain; Region: Thioester-redct; TIGR01746 1144275013268 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1144275013269 putative NAD(P) binding site [chemical binding]; other site 1144275013270 active site 1144275013271 putative substrate binding site [chemical binding]; other site 1144275013272 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1144275013273 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 1144275013274 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275013275 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1144275013276 Zn binding site [ion binding]; other site 1144275013277 REJ domain; Region: REJ; pfam02010 1144275013278 REJ domain; Region: REJ; pfam02010 1144275013279 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275013280 active site 2 [active] 1144275013281 active site 1 [active] 1144275013282 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1144275013283 active site 1144275013284 catalytic site [active] 1144275013285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275013286 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275013287 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275013288 HSP70 interaction site [polypeptide binding]; other site 1144275013289 TPR repeat; Region: TPR_11; pfam13414 1144275013290 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275013291 binding surface 1144275013292 TPR motif; other site 1144275013293 acetylornithine aminotransferase; Provisional; Region: PRK02627 1144275013294 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1144275013295 inhibitor-cofactor binding pocket; inhibition site 1144275013296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275013297 catalytic residue [active] 1144275013298 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1144275013299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275013300 Walker A motif; other site 1144275013301 ATP binding site [chemical binding]; other site 1144275013302 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013303 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275013304 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1144275013305 active site 1144275013306 HslU subunit interaction site [polypeptide binding]; other site 1144275013307 Protein of unknown function (DUF419); Region: DUF419; cl15265 1144275013308 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1144275013309 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275013310 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1144275013311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013312 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1144275013313 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275013314 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275013315 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275013316 DNA topoisomerase I; Validated; Region: PRK06599 1144275013317 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1144275013318 active site 1144275013319 interdomain interaction site; other site 1144275013320 putative metal-binding site [ion binding]; other site 1144275013321 nucleotide binding site [chemical binding]; other site 1144275013322 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1144275013323 domain I; other site 1144275013324 DNA binding groove [nucleotide binding] 1144275013325 phosphate binding site [ion binding]; other site 1144275013326 domain II; other site 1144275013327 domain III; other site 1144275013328 nucleotide binding site [chemical binding]; other site 1144275013329 catalytic site [active] 1144275013330 domain IV; other site 1144275013331 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1144275013332 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1144275013333 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1144275013334 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 1144275013335 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1144275013336 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1144275013337 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1144275013338 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275013339 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275013340 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1144275013341 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1144275013342 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1144275013343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275013344 dimerization interface [polypeptide binding]; other site 1144275013345 GAF domain; Region: GAF_2; pfam13185 1144275013346 GAF domain; Region: GAF; cl15785 1144275013347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275013348 metal binding site [ion binding]; metal-binding site 1144275013349 active site 1144275013350 I-site; other site 1144275013351 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1144275013352 active site 1144275013353 catalytic triad [active] 1144275013354 oxyanion hole [active] 1144275013355 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1144275013356 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275013357 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275013358 protein binding site [polypeptide binding]; other site 1144275013359 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275013360 protein binding site [polypeptide binding]; other site 1144275013361 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1144275013362 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1144275013363 active site 1144275013364 substrate binding site [chemical binding]; other site 1144275013365 catalytic site [active] 1144275013366 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1144275013367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1144275013368 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1144275013369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275013370 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275013371 large tegument protein UL36; Provisional; Region: PHA03247 1144275013372 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275013373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013374 active site 1144275013375 phosphorylation site [posttranslational modification] 1144275013376 intermolecular recognition site; other site 1144275013377 dimerization interface [polypeptide binding]; other site 1144275013378 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275013379 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275013380 hypothetical protein; Validated; Region: PRK09039 1144275013381 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1144275013382 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275013383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275013384 Walker A motif; other site 1144275013385 ATP binding site [chemical binding]; other site 1144275013386 Walker B motif; other site 1144275013387 arginine finger; other site 1144275013388 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1144275013389 homodimer interface [polypeptide binding]; other site 1144275013390 substrate-cofactor binding pocket; other site 1144275013391 catalytic residue [active] 1144275013392 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1144275013393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013394 Fic/DOC family; Region: Fic; cl00960 1144275013395 endonuclease IV; Provisional; Region: PRK01060 1144275013396 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1144275013397 AP (apurinic/apyrimidinic) site pocket; other site 1144275013398 DNA interaction; other site 1144275013399 Metal-binding active site; metal-binding site 1144275013400 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1144275013401 DHH family; Region: DHH; pfam01368 1144275013402 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1144275013403 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275013404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275013405 catalytic residue [active] 1144275013406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275013407 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013408 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275013409 active site 1144275013410 ATP binding site [chemical binding]; other site 1144275013411 substrate binding site [chemical binding]; other site 1144275013412 activation loop (A-loop); other site 1144275013413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275013414 binding surface 1144275013415 TPR motif; other site 1144275013416 TPR repeat; Region: TPR_11; pfam13414 1144275013417 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1144275013418 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1144275013419 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1144275013420 active site 1144275013421 HIGH motif; other site 1144275013422 dimer interface [polypeptide binding]; other site 1144275013423 KMSKS motif; other site 1144275013424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1144275013425 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275013426 classical (c) SDRs; Region: SDR_c; cd05233 1144275013427 NAD(P) binding site [chemical binding]; other site 1144275013428 active site 1144275013429 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1144275013430 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275013431 MG2 domain; Region: A2M_N; pfam01835 1144275013432 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1144275013433 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275013434 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1144275013435 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1144275013436 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275013437 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1144275013438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275013439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275013440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275013441 active site 1144275013442 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275013443 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275013444 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1144275013445 Protein export membrane protein; Region: SecD_SecF; cl14618 1144275013446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275013447 Helix-turn-helix domains; Region: HTH; cl00088 1144275013448 acyl-CoA synthetase; Validated; Region: PRK09192 1144275013449 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275013450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275013451 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275013452 active site 1144275013453 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1144275013454 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1144275013455 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1144275013456 SCP-2 sterol transfer family; Region: SCP2; cl01225 1144275013457 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275013458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013459 active site 1144275013460 phosphorylation site [posttranslational modification] 1144275013461 intermolecular recognition site; other site 1144275013462 dimerization interface [polypeptide binding]; other site 1144275013463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275013464 dimer interface [polypeptide binding]; other site 1144275013465 phosphorylation site [posttranslational modification] 1144275013466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275013467 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1144275013468 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1144275013469 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275013470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275013471 TPR motif; other site 1144275013472 binding surface 1144275013473 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275013474 CoenzymeA binding site [chemical binding]; other site 1144275013475 subunit interaction site [polypeptide binding]; other site 1144275013476 PHB binding site; other site 1144275013477 acyl-CoA synthetase; Validated; Region: PRK05850 1144275013478 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275013479 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275013480 active site 1144275013481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013482 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1144275013483 Enoylreductase; Region: PKS_ER; smart00829 1144275013484 NAD(P) binding site [chemical binding]; other site 1144275013485 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1144275013486 putative NADP binding site [chemical binding]; other site 1144275013487 active site 1144275013488 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275013489 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1144275013490 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275013491 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275013492 active site 1144275013493 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275013494 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275013495 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1144275013496 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1144275013497 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 1144275013498 nucleophilic elbow; other site 1144275013499 catalytic triad; other site 1144275013500 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275013501 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275013502 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275013503 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275013504 active site 1144275013505 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1144275013506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275013507 S-adenosylmethionine binding site [chemical binding]; other site 1144275013508 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275013509 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275013510 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275013511 Di-iron ligands [ion binding]; other site 1144275013512 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275013513 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275013514 Di-iron ligands [ion binding]; other site 1144275013515 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275013516 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1144275013517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1144275013518 nudix motif; other site 1144275013519 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1144275013520 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1144275013521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275013522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275013523 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275013524 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1144275013525 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1144275013526 GTP cyclohydrolase I; Provisional; Region: PLN03044 1144275013527 active site 1144275013528 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1144275013529 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1144275013530 intersubunit interface [polypeptide binding]; other site 1144275013531 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1144275013532 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1144275013533 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1144275013534 ABC-ATPase subunit interface; other site 1144275013535 dimer interface [polypeptide binding]; other site 1144275013536 putative PBP binding regions; other site 1144275013537 Isochorismatase family; Region: Isochorismatase; pfam00857 1144275013538 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1144275013539 catalytic triad [active] 1144275013540 dimer interface [polypeptide binding]; other site 1144275013541 conserved cis-peptide bond; other site 1144275013542 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503 1144275013543 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1144275013544 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1144275013545 dimer interface [polypeptide binding]; other site 1144275013546 [2Fe-2S] cluster binding site [ion binding]; other site 1144275013547 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1144275013548 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1144275013549 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1144275013550 active site 1144275013551 dimer interface [polypeptide binding]; other site 1144275013552 effector binding site; other site 1144275013553 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1144275013554 TSCPD domain; Region: TSCPD; cl14834 1144275013555 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275013556 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1144275013557 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275013558 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275013559 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275013560 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275013561 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275013562 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1144275013563 Bacterial sugar transferase; Region: Bac_transf; cl00939 1144275013564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275013565 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1144275013566 putative ADP-binding pocket [chemical binding]; other site 1144275013567 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1144275013568 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275013569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275013570 putative substrate translocation pore; other site 1144275013571 transcriptional regulator; Provisional; Region: PRK10632 1144275013572 Helix-turn-helix domains; Region: HTH; cl00088 1144275013573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275013574 dimerization interface [polypeptide binding]; other site 1144275013575 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1144275013576 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275013577 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 1144275013578 O-Antigen ligase; Region: Wzy_C; cl04850 1144275013579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275013580 putative substrate translocation pore; other site 1144275013581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275013582 putative phosphoketolase; Provisional; Region: PRK05261 1144275013583 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1144275013584 TPP-binding site; other site 1144275013585 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 1144275013586 XFP C-terminal domain; Region: XFP_C; pfam09363 1144275013587 Acetokinase family; Region: Acetate_kinase; cl01029 1144275013588 acetate kinase; Region: ackA; TIGR00016 1144275013589 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1144275013590 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1144275013591 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1144275013592 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1144275013593 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1144275013594 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275013595 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1144275013596 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1144275013597 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275013598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275013599 binding surface 1144275013600 TPR motif; other site 1144275013601 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1144275013602 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1144275013603 purine monophosphate binding site [chemical binding]; other site 1144275013604 dimer interface [polypeptide binding]; other site 1144275013605 putative catalytic residues [active] 1144275013606 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1144275013607 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1144275013608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275013609 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1144275013610 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275013611 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275013612 active site 1144275013613 ATP binding site [chemical binding]; other site 1144275013614 substrate binding site [chemical binding]; other site 1144275013615 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013616 substrate binding site [chemical binding]; other site 1144275013617 activation loop (A-loop); other site 1144275013618 activation loop (A-loop); other site 1144275013619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275013620 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013621 active site 1144275013622 ATP binding site [chemical binding]; other site 1144275013623 substrate binding site [chemical binding]; other site 1144275013624 activation loop (A-loop); other site 1144275013625 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275013626 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1144275013627 Penicillin amidase; Region: Penicil_amidase; pfam01804 1144275013628 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275013629 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1144275013630 active site 1144275013631 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275013632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013633 ATP binding site [chemical binding]; other site 1144275013634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275013635 S-adenosylmethionine binding site [chemical binding]; other site 1144275013636 PilZ domain; Region: PilZ; cl01260 1144275013637 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275013638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275013639 Walker A motif; other site 1144275013640 ATP binding site [chemical binding]; other site 1144275013641 Walker B motif; other site 1144275013642 arginine finger; other site 1144275013643 Helix-turn-helix domains; Region: HTH; cl00088 1144275013644 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275013645 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1144275013646 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1144275013647 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1144275013648 active site 1144275013649 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1144275013650 catalytic triad [active] 1144275013651 dimer interface [polypeptide binding]; other site 1144275013652 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275013653 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1144275013654 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275013655 Zn binding site [ion binding]; other site 1144275013656 PhoD-like phosphatase; Region: PhoD; pfam09423 1144275013657 PhoD-like phosphatase; Region: PhoD; pfam09423 1144275013658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1144275013659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275013660 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 1144275013661 active site 1144275013662 metal binding site [ion binding]; metal-binding site 1144275013663 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1144275013664 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275013665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275013666 dimer interface [polypeptide binding]; other site 1144275013667 phosphorylation site [posttranslational modification] 1144275013668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275013669 ATP binding site [chemical binding]; other site 1144275013670 Mg2+ binding site [ion binding]; other site 1144275013671 G-X-G motif; other site 1144275013672 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275013673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013674 active site 1144275013675 phosphorylation site [posttranslational modification] 1144275013676 intermolecular recognition site; other site 1144275013677 dimerization interface [polypeptide binding]; other site 1144275013678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275013679 dimer interface [polypeptide binding]; other site 1144275013680 phosphorylation site [posttranslational modification] 1144275013681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275013682 ATP binding site [chemical binding]; other site 1144275013683 Mg2+ binding site [ion binding]; other site 1144275013684 G-X-G motif; other site 1144275013685 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1144275013686 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1144275013687 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275013688 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1144275013689 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1144275013690 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1144275013691 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1144275013692 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1144275013693 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275013694 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1144275013695 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1144275013696 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275013697 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275013698 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275013699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013700 active site 1144275013701 phosphorylation site [posttranslational modification] 1144275013702 intermolecular recognition site; other site 1144275013703 dimerization interface [polypeptide binding]; other site 1144275013704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275013705 dimer interface [polypeptide binding]; other site 1144275013706 phosphorylation site [posttranslational modification] 1144275013707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275013708 ATP binding site [chemical binding]; other site 1144275013709 Mg2+ binding site [ion binding]; other site 1144275013710 G-X-G motif; other site 1144275013711 circadian clock protein KaiC; Reviewed; Region: PRK09302 1144275013712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013713 Walker A motif; other site 1144275013714 ATP binding site [chemical binding]; other site 1144275013715 Walker B motif; other site 1144275013716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013717 ATP binding site [chemical binding]; other site 1144275013718 Walker B motif; other site 1144275013719 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275013720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013721 active site 1144275013722 phosphorylation site [posttranslational modification] 1144275013723 intermolecular recognition site; other site 1144275013724 dimerization interface [polypeptide binding]; other site 1144275013725 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1144275013726 MatE; Region: MatE; cl10513 1144275013727 MatE; Region: MatE; cl10513 1144275013728 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1144275013729 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1144275013730 NAD binding site [chemical binding]; other site 1144275013731 catalytic Zn binding site [ion binding]; other site 1144275013732 structural Zn binding site [ion binding]; other site 1144275013733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275013734 active site 1144275013735 phosphorylation site [posttranslational modification] 1144275013736 intermolecular recognition site; other site 1144275013737 dimerization interface [polypeptide binding]; other site 1144275013738 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1144275013739 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275013740 substrate binding pocket [chemical binding]; other site 1144275013741 catalytic triad [active] 1144275013742 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1144275013743 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275013744 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275013745 dimer interface [polypeptide binding]; other site 1144275013746 putative CheW interface [polypeptide binding]; other site 1144275013747 Haemolysin-III related; Region: HlyIII; cl03831 1144275013748 hypothetical protein; Provisional; Region: PRK06185 1144275013749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013750 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1144275013751 putative hydrophobic ligand binding site [chemical binding]; other site 1144275013752 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1144275013753 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275013754 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275013755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275013756 S-adenosylmethionine binding site [chemical binding]; other site 1144275013757 OsmC-like protein; Region: OsmC; cl00767 1144275013758 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275013759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275013760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275013761 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275013762 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275013763 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 1144275013764 YceI-like domain; Region: YceI; cl01001 1144275013765 LysR family transcriptional regulator; Provisional; Region: PRK14997 1144275013766 Helix-turn-helix domains; Region: HTH; cl00088 1144275013767 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275013768 putative effector binding pocket; other site 1144275013769 dimerization interface [polypeptide binding]; other site 1144275013770 Pirin-related protein [General function prediction only]; Region: COG1741 1144275013771 Cupin domain; Region: Cupin_2; cl09118 1144275013772 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275013773 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275013774 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275013775 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275013776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275013777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013778 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1144275013779 AAA ATPase domain; Region: AAA_15; pfam13175 1144275013780 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013781 ABC transporter signature motif; other site 1144275013782 Walker B; other site 1144275013783 D-loop; other site 1144275013784 H-loop/switch region; other site 1144275013785 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1144275013786 active site 1144275013787 metal binding site [ion binding]; metal-binding site 1144275013788 Helix-turn-helix domains; Region: HTH; cl00088 1144275013789 Integrase core domain; Region: rve; cl01316 1144275013790 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1144275013791 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1144275013792 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 1144275013793 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1144275013794 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1144275013795 SpaB C-terminal domain; Region: SpaB_C; cl14828 1144275013796 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1144275013797 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275013798 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 1144275013799 active site 1144275013800 zinc binding site [ion binding]; other site 1144275013801 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275013802 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275013803 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275013804 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1144275013805 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 1144275013806 putative active site [active] 1144275013807 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1144275013808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013809 Walker A/P-loop; other site 1144275013810 ATP binding site [chemical binding]; other site 1144275013811 Q-loop/lid; other site 1144275013812 ABC transporter signature motif; other site 1144275013813 Walker B; other site 1144275013814 D-loop; other site 1144275013815 H-loop/switch region; other site 1144275013816 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1144275013817 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275013818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275013819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275013820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275013821 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1144275013822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275013823 ATP binding site [chemical binding]; other site 1144275013824 putative Mg++ binding site [ion binding]; other site 1144275013825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275013826 nucleotide binding region [chemical binding]; other site 1144275013827 ATP-binding site [chemical binding]; other site 1144275013828 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1144275013829 catalytic site [active] 1144275013830 putative active site [active] 1144275013831 putative substrate binding site [chemical binding]; other site 1144275013832 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1144275013833 PglZ domain; Region: PglZ; pfam08665 1144275013834 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275013835 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 1144275013836 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1144275013837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275013838 Restriction endonuclease; Region: Mrr_cat; cl00516 1144275013839 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013840 active site 1144275013841 ATP binding site [chemical binding]; other site 1144275013842 substrate binding site [chemical binding]; other site 1144275013843 activation loop (A-loop); other site 1144275013844 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275013845 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275013846 active site 1144275013847 ATP binding site [chemical binding]; other site 1144275013848 substrate binding site [chemical binding]; other site 1144275013849 activation loop (A-loop); other site 1144275013850 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1144275013851 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1144275013852 substrate binding site [chemical binding]; other site 1144275013853 dimer interface [polypeptide binding]; other site 1144275013854 catalytic triad [active] 1144275013855 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1144275013856 Phosphoglycerate kinase; Region: PGK; pfam00162 1144275013857 substrate binding site [chemical binding]; other site 1144275013858 hinge regions; other site 1144275013859 ADP binding site [chemical binding]; other site 1144275013860 catalytic site [active] 1144275013861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013862 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1144275013863 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1144275013864 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 1144275013865 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1144275013866 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1144275013867 active site 1144275013868 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1144275013869 Interdomain contacts; other site 1144275013870 Cytokine receptor motif; other site 1144275013871 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1144275013872 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1144275013873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013874 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1144275013875 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1144275013876 putative RNA binding site [nucleotide binding]; other site 1144275013877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275013878 S-adenosylmethionine binding site [chemical binding]; other site 1144275013879 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 1144275013880 generic binding surface II; other site 1144275013881 generic binding surface I; other site 1144275013882 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275013883 Zn2+ binding site [ion binding]; other site 1144275013884 Mg2+ binding site [ion binding]; other site 1144275013885 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1144275013886 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275013887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275013888 Zn2+ binding site [ion binding]; other site 1144275013889 Mg2+ binding site [ion binding]; other site 1144275013890 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275013891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275013892 active site 1144275013893 phosphorylation site [posttranslational modification] 1144275013894 intermolecular recognition site; other site 1144275013895 dimerization interface [polypeptide binding]; other site 1144275013896 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1144275013897 active site 1144275013898 putative lyase; Provisional; Region: PRK09687 1144275013899 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1144275013900 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1144275013901 active site 1144275013902 HIGH motif; other site 1144275013903 KMSKS motif; other site 1144275013904 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1144275013905 anticodon binding site; other site 1144275013906 tRNA binding surface [nucleotide binding]; other site 1144275013907 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1144275013908 dimer interface [polypeptide binding]; other site 1144275013909 putative tRNA-binding site [nucleotide binding]; other site 1144275013910 NRDE protein; Region: NRDE; cl01315 1144275013911 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275013912 active site 1144275013913 nucleophile elbow; other site 1144275013914 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1144275013915 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275013916 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275013917 active site 1144275013918 Zn binding site [ion binding]; other site 1144275013919 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275013920 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1144275013921 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1144275013922 DNA polymerase III subunit delta; Validated; Region: PRK07452 1144275013923 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1144275013924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275013925 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1144275013926 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275013927 ligand binding site [chemical binding]; other site 1144275013928 flexible hinge region; other site 1144275013929 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1144275013930 trimer interface [polypeptide binding]; other site 1144275013931 active site 1144275013932 substrate binding site [chemical binding]; other site 1144275013933 CoA binding site [chemical binding]; other site 1144275013934 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1144275013935 trimer interface [polypeptide binding]; other site 1144275013936 active site 1144275013937 substrate binding site [chemical binding]; other site 1144275013938 CoA binding site [chemical binding]; other site 1144275013939 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1144275013940 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1144275013941 active site 1144275013942 dimer interface [polypeptide binding]; other site 1144275013943 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1144275013944 Ligand Binding Site [chemical binding]; other site 1144275013945 Molecular Tunnel; other site 1144275013946 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1144275013947 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275013948 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275013949 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1144275013950 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1144275013951 homodimer interface [polypeptide binding]; other site 1144275013952 NAD binding pocket [chemical binding]; other site 1144275013953 ATP binding pocket [chemical binding]; other site 1144275013954 Mg binding site [ion binding]; other site 1144275013955 active-site loop [active] 1144275013956 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 1144275013957 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1144275013958 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275013959 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1144275013960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275013961 catalytic residue [active] 1144275013962 cysteine synthase B; Region: cysM; TIGR01138 1144275013963 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1144275013964 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1144275013965 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1144275013966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275013967 dimer interface [polypeptide binding]; other site 1144275013968 phosphorylation site [posttranslational modification] 1144275013969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275013970 ATP binding site [chemical binding]; other site 1144275013971 Mg2+ binding site [ion binding]; other site 1144275013972 G-X-G motif; other site 1144275013973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275013974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013975 active site 1144275013976 phosphorylation site [posttranslational modification] 1144275013977 intermolecular recognition site; other site 1144275013978 dimerization interface [polypeptide binding]; other site 1144275013979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275013980 DNA binding site [nucleotide binding] 1144275013981 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275013982 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1144275013983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275013984 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1144275013985 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1144275013986 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 1144275013987 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1144275013988 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275013989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275013990 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275013991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275013992 dimer interface [polypeptide binding]; other site 1144275013993 phosphorylation site [posttranslational modification] 1144275013994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275013995 ATP binding site [chemical binding]; other site 1144275013996 Mg2+ binding site [ion binding]; other site 1144275013997 G-X-G motif; other site 1144275013998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275013999 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014000 active site 1144275014001 phosphorylation site [posttranslational modification] 1144275014002 intermolecular recognition site; other site 1144275014003 dimerization interface [polypeptide binding]; other site 1144275014004 Protein of unknown function (DUF2400); Region: DUF2400; cl09884 1144275014005 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1144275014006 MPT binding site; other site 1144275014007 trimer interface [polypeptide binding]; other site 1144275014008 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1144275014009 iron-sulfur cluster [ion binding]; other site 1144275014010 [2Fe-2S] cluster binding site [ion binding]; other site 1144275014011 hypothetical protein; Provisional; Region: PRK08609 1144275014012 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1144275014013 active site 1144275014014 primer binding site [nucleotide binding]; other site 1144275014015 NTP binding site [chemical binding]; other site 1144275014016 metal binding triad [ion binding]; metal-binding site 1144275014017 CAAX protease self-immunity; Region: Abi; cl00558 1144275014018 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1144275014019 putative active site [active] 1144275014020 putative dimer interface [polypeptide binding]; other site 1144275014021 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275014022 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275014023 HSP70 interaction site [polypeptide binding]; other site 1144275014024 Colicin V production protein; Region: Colicin_V; cl00567 1144275014025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275014026 Walker A motif; other site 1144275014027 ATP binding site [chemical binding]; other site 1144275014028 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1144275014029 Walker B motif; other site 1144275014030 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275014031 arginine decarboxylase; Provisional; Region: PRK05354 1144275014032 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1144275014033 active site 1144275014034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275014035 catalytic residues [active] 1144275014036 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1144275014037 OsmC-like protein; Region: OsmC; cl00767 1144275014038 Deoxyhypusine synthase; Region: DS; cl00826 1144275014039 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1144275014040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275014041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275014042 dimer interface [polypeptide binding]; other site 1144275014043 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1144275014044 putative CheW interface [polypeptide binding]; other site 1144275014045 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1144275014046 NADH dehydrogenase subunit B; Provisional; Region: PRK14817 1144275014047 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 1144275014048 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1144275014049 CoenzymeA binding site [chemical binding]; other site 1144275014050 subunit interaction site [polypeptide binding]; other site 1144275014051 PHB binding site; other site 1144275014052 Sulfatase; Region: Sulfatase; cl10460 1144275014053 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1144275014054 cyclase homology domain; Region: CHD; cd07302 1144275014055 nucleotidyl binding site; other site 1144275014056 metal binding site [ion binding]; metal-binding site 1144275014057 dimer interface [polypeptide binding]; other site 1144275014058 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1144275014059 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 1144275014060 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 1144275014061 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275014062 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1144275014063 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1144275014064 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275014065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275014066 NADH dehydrogenase; Region: NADHdh; cl00469 1144275014067 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1144275014068 4Fe-4S binding domain; Region: Fer4; cl02805 1144275014069 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1144275014070 [2Fe-2S] cluster binding site [ion binding]; other site 1144275014071 dimer interface [polypeptide binding]; other site 1144275014072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275014073 CHASE2 domain; Region: CHASE2; cl01732 1144275014074 CHASE2 domain; Region: CHASE2; cl01732 1144275014075 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1144275014076 cyclase homology domain; Region: CHD; cd07302 1144275014077 nucleotidyl binding site; other site 1144275014078 metal binding site [ion binding]; metal-binding site 1144275014079 dimer interface [polypeptide binding]; other site 1144275014080 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1144275014081 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 1144275014082 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275014083 putative catalytic site [active] 1144275014084 putative metal binding site [ion binding]; other site 1144275014085 putative phosphate binding site [ion binding]; other site 1144275014086 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275014087 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1144275014088 Helix-turn-helix domains; Region: HTH; cl00088 1144275014089 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1144275014090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275014091 non-specific DNA binding site [nucleotide binding]; other site 1144275014092 salt bridge; other site 1144275014093 sequence-specific DNA binding site [nucleotide binding]; other site 1144275014094 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1144275014095 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1144275014096 AMIN domain; Region: AMIN; pfam11741 1144275014097 AMIN domain; Region: AMIN; pfam11741 1144275014098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275014099 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1144275014100 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1144275014101 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1144275014102 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1144275014103 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1144275014104 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275014105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275014106 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1144275014107 ligand binding site [chemical binding]; other site 1144275014108 flexible hinge region; other site 1144275014109 Helix-turn-helix domains; Region: HTH; cl00088 1144275014110 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1144275014111 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1144275014112 dimerization interface [polypeptide binding]; other site 1144275014113 putative ATP binding site [chemical binding]; other site 1144275014114 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1144275014115 active site 1144275014116 cosubstrate binding site; other site 1144275014117 substrate binding site [chemical binding]; other site 1144275014118 catalytic site [active] 1144275014119 Protein of unknown function (DUF523); Region: DUF523; cl00733 1144275014120 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1144275014121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275014122 substrate binding site [chemical binding]; other site 1144275014123 oxyanion hole (OAH) forming residues; other site 1144275014124 trimer interface [polypeptide binding]; other site 1144275014125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1144275014126 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1144275014127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275014128 motif II; other site 1144275014129 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1144275014130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275014131 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1144275014132 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1144275014133 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1144275014134 putative active site [active] 1144275014135 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1144275014136 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1144275014137 G1 box; other site 1144275014138 GTP/Mg2+ binding site [chemical binding]; other site 1144275014139 G2 box; other site 1144275014140 Switch I region; other site 1144275014141 G3 box; other site 1144275014142 Switch II region; other site 1144275014143 G4 box; other site 1144275014144 G5 box; other site 1144275014145 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275014146 Sulfatase; Region: Sulfatase; cl10460 1144275014147 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275014148 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1144275014149 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1144275014150 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1144275014151 active site 1144275014152 catalytic site [active] 1144275014153 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1144275014154 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1144275014155 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1144275014156 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1144275014157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275014158 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1144275014159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275014160 dimer interface [polypeptide binding]; other site 1144275014161 phosphorylation site [posttranslational modification] 1144275014162 UV excision repair protein Rad23; Region: rad23; TIGR00601 1144275014163 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1144275014164 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275014165 putative binding surface; other site 1144275014166 active site 1144275014167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014168 ATP binding site [chemical binding]; other site 1144275014169 Mg2+ binding site [ion binding]; other site 1144275014170 G-X-G motif; other site 1144275014171 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275014172 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014174 active site 1144275014175 phosphorylation site [posttranslational modification] 1144275014176 intermolecular recognition site; other site 1144275014177 dimerization interface [polypeptide binding]; other site 1144275014178 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275014179 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014181 active site 1144275014182 phosphorylation site [posttranslational modification] 1144275014183 intermolecular recognition site; other site 1144275014184 dimerization interface [polypeptide binding]; other site 1144275014185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275014186 dimerization interface [polypeptide binding]; other site 1144275014187 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275014188 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275014189 dimer interface [polypeptide binding]; other site 1144275014190 putative CheW interface [polypeptide binding]; other site 1144275014191 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1144275014192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275014193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275014194 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1144275014195 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275014196 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275014197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275014198 active site 1144275014199 ATP binding site [chemical binding]; other site 1144275014200 substrate binding site [chemical binding]; other site 1144275014201 activation loop (A-loop); other site 1144275014202 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275014203 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275014204 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1144275014205 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275014206 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275014207 active site 1144275014208 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1144275014209 active site 1144275014210 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1144275014211 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1144275014212 active site 1144275014213 HIGH motif; other site 1144275014214 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1144275014215 active site 1144275014216 KMSKS motif; other site 1144275014217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014218 active site 1144275014219 phosphorylation site [posttranslational modification] 1144275014220 intermolecular recognition site; other site 1144275014221 dimerization interface [polypeptide binding]; other site 1144275014222 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014224 active site 1144275014225 phosphorylation site [posttranslational modification] 1144275014226 intermolecular recognition site; other site 1144275014227 dimerization interface [polypeptide binding]; other site 1144275014228 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1144275014229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014230 ATP binding site [chemical binding]; other site 1144275014231 Mg2+ binding site [ion binding]; other site 1144275014232 G-X-G motif; other site 1144275014233 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1144275014234 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1144275014235 E3 interaction surface; other site 1144275014236 lipoyl attachment site [posttranslational modification]; other site 1144275014237 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1144275014238 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1144275014239 E3 interaction surface; other site 1144275014240 lipoyl attachment site [posttranslational modification]; other site 1144275014241 e3 binding domain; Region: E3_binding; pfam02817 1144275014242 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1144275014243 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 1144275014244 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1144275014245 alpha subunit interface [polypeptide binding]; other site 1144275014246 TPP binding site [chemical binding]; other site 1144275014247 heterodimer interface [polypeptide binding]; other site 1144275014248 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1144275014249 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1144275014250 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1144275014251 tetramer interface [polypeptide binding]; other site 1144275014252 TPP-binding site [chemical binding]; other site 1144275014253 heterodimer interface [polypeptide binding]; other site 1144275014254 phosphorylation loop region [posttranslational modification] 1144275014255 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1144275014256 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1144275014257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275014258 putative substrate translocation pore; other site 1144275014259 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1144275014260 nudix motif; other site 1144275014261 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1144275014262 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1144275014263 active site 1144275014264 metal binding site [ion binding]; metal-binding site 1144275014265 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275014266 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275014267 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1144275014268 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1144275014269 Walker A motif; other site 1144275014270 ATP binding site [chemical binding]; other site 1144275014271 Walker B motif; other site 1144275014272 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1144275014273 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1144275014274 active site 1144275014275 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1144275014276 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1144275014277 domain interfaces; other site 1144275014278 active site 1144275014279 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1144275014280 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1144275014281 tRNA; other site 1144275014282 putative tRNA binding site [nucleotide binding]; other site 1144275014283 putative NADP binding site [chemical binding]; other site 1144275014284 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1144275014285 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1144275014286 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1144275014287 catalytic residues [active] 1144275014288 PilZ domain; Region: PilZ; cl01260 1144275014289 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1144275014290 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1144275014291 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1144275014292 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275014293 rod shape-determining protein MreC; Region: MreC; pfam04085 1144275014294 SurA N-terminal domain; Region: SurA_N_3; cl07813 1144275014295 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1144275014296 GAF domain; Region: GAF; cl15785 1144275014297 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275014298 metal binding site [ion binding]; metal-binding site 1144275014299 active site 1144275014300 I-site; other site 1144275014301 Maf-like protein; Region: Maf; pfam02545 1144275014302 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1144275014303 active site 1144275014304 dimer interface [polypeptide binding]; other site 1144275014305 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1144275014306 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275014307 catalytic residue [active] 1144275014308 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1144275014309 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1144275014310 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1144275014311 Protein of unknown function (DUF507); Region: DUF507; cl01112 1144275014312 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1144275014313 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1144275014314 GIY-YIG motif/motif A; other site 1144275014315 active site 1144275014316 catalytic site [active] 1144275014317 putative DNA binding site [nucleotide binding]; other site 1144275014318 metal binding site [ion binding]; metal-binding site 1144275014319 UvrB/uvrC motif; Region: UVR; pfam02151 1144275014320 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1144275014321 excinuclease ABC subunit B; Provisional; Region: PRK05298 1144275014322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275014323 ATP binding site [chemical binding]; other site 1144275014324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275014325 nucleotide binding region [chemical binding]; other site 1144275014326 ATP-binding site [chemical binding]; other site 1144275014327 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1144275014328 UvrB/uvrC motif; Region: UVR; pfam02151 1144275014329 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275014330 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1144275014331 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1144275014332 PA/protease or protease-like domain interface [polypeptide binding]; other site 1144275014333 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 1144275014334 metal binding site [ion binding]; metal-binding site 1144275014335 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1144275014336 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1144275014337 active site 1144275014338 HIGH motif; other site 1144275014339 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1144275014340 KMSKS motif; other site 1144275014341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1144275014342 tRNA binding surface [nucleotide binding]; other site 1144275014343 anticodon binding site; other site 1144275014344 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275014345 phosphopeptide binding site; other site 1144275014346 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1144275014347 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1144275014348 Competence protein; Region: Competence; cl00471 1144275014349 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275014350 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 1144275014351 putative ligand binding site [chemical binding]; other site 1144275014352 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275014353 phosphopeptide binding site; other site 1144275014354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275014355 binding surface 1144275014356 TPR motif; other site 1144275014357 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1144275014358 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1144275014359 GDP-binding site [chemical binding]; other site 1144275014360 ACT binding site; other site 1144275014361 IMP binding site; other site 1144275014362 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1144275014363 Family description; Region: UvrD_C_2; cl15862 1144275014364 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1144275014365 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1144275014366 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 1144275014367 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1144275014368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275014369 transcriptional regulator; Provisional; Region: PRK10632 1144275014370 Helix-turn-helix domains; Region: HTH; cl00088 1144275014371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275014372 dimerization interface [polypeptide binding]; other site 1144275014373 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 1144275014374 active site 1144275014375 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275014376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275014377 DNA-binding site [nucleotide binding]; DNA binding site 1144275014378 CHASE3 domain; Region: CHASE3; cl05000 1144275014379 GAF domain; Region: GAF_2; pfam13185 1144275014380 GAF domain; Region: GAF; cl15785 1144275014381 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1144275014382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275014383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014384 ATP binding site [chemical binding]; other site 1144275014385 Mg2+ binding site [ion binding]; other site 1144275014386 G-X-G motif; other site 1144275014387 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014389 active site 1144275014390 phosphorylation site [posttranslational modification] 1144275014391 intermolecular recognition site; other site 1144275014392 dimerization interface [polypeptide binding]; other site 1144275014393 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275014394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014395 active site 1144275014396 phosphorylation site [posttranslational modification] 1144275014397 intermolecular recognition site; other site 1144275014398 dimerization interface [polypeptide binding]; other site 1144275014399 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014401 active site 1144275014402 phosphorylation site [posttranslational modification] 1144275014403 intermolecular recognition site; other site 1144275014404 dimerization interface [polypeptide binding]; other site 1144275014405 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1144275014406 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1144275014407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275014408 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275014409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014410 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014411 active site 1144275014412 phosphorylation site [posttranslational modification] 1144275014413 intermolecular recognition site; other site 1144275014414 dimerization interface [polypeptide binding]; other site 1144275014415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275014416 dimer interface [polypeptide binding]; other site 1144275014417 phosphorylation site [posttranslational modification] 1144275014418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014419 ATP binding site [chemical binding]; other site 1144275014420 Mg2+ binding site [ion binding]; other site 1144275014421 G-X-G motif; other site 1144275014422 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275014423 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275014424 active site 1144275014425 metal binding site [ion binding]; metal-binding site 1144275014426 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1144275014427 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1144275014428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275014429 Q-loop/lid; other site 1144275014430 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1144275014431 ABC transporter signature motif; other site 1144275014432 Walker B; other site 1144275014433 D-loop; other site 1144275014434 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1144275014435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275014436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275014437 putative substrate translocation pore; other site 1144275014438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1144275014439 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1144275014440 PAS domain; Region: PAS_9; pfam13426 1144275014441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275014442 putative active site [active] 1144275014443 heme pocket [chemical binding]; other site 1144275014444 GAF domain; Region: GAF_2; pfam13185 1144275014445 GAF domain; Region: GAF; cl15785 1144275014446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275014447 dimer interface [polypeptide binding]; other site 1144275014448 phosphorylation site [posttranslational modification] 1144275014449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014450 ATP binding site [chemical binding]; other site 1144275014451 Mg2+ binding site [ion binding]; other site 1144275014452 G-X-G motif; other site 1144275014453 FIST N domain; Region: FIST; cl10701 1144275014454 FIST C domain; Region: FIST_C; pfam10442 1144275014455 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1144275014456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275014457 putative substrate translocation pore; other site 1144275014458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1144275014459 Heme NO binding; Region: HNOB; cl15268 1144275014460 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 1144275014461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014462 ATP binding site [chemical binding]; other site 1144275014463 Mg2+ binding site [ion binding]; other site 1144275014464 G-X-G motif; other site 1144275014465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014466 active site 1144275014467 phosphorylation site [posttranslational modification] 1144275014468 intermolecular recognition site; other site 1144275014469 dimerization interface [polypeptide binding]; other site 1144275014470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275014471 dimer interface [polypeptide binding]; other site 1144275014472 phosphorylation site [posttranslational modification] 1144275014473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014474 ATP binding site [chemical binding]; other site 1144275014475 Mg2+ binding site [ion binding]; other site 1144275014476 G-X-G motif; other site 1144275014477 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275014478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275014479 S-adenosylmethionine binding site [chemical binding]; other site 1144275014480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275014481 active site 1144275014482 intermolecular recognition site; other site 1144275014483 dimerization interface [polypeptide binding]; other site 1144275014484 Quinolinate synthetase A protein; Region: NadA; cl00420 1144275014485 Protein of unknown function DUF45; Region: DUF45; cl00636 1144275014486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275014487 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275014488 active site 1144275014489 ATP binding site [chemical binding]; other site 1144275014490 substrate binding site [chemical binding]; other site 1144275014491 activation loop (A-loop); other site 1144275014492 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1144275014493 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1144275014494 putative active site [active] 1144275014495 catalytic site [active] 1144275014496 putative metal binding site [ion binding]; other site 1144275014497 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1144275014498 AAA domain; Region: AAA_18; pfam13238 1144275014499 Substrate-binding site [chemical binding]; other site 1144275014500 Substrate specificity [chemical binding]; other site 1144275014501 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1144275014502 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1144275014503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1144275014504 active site residue [active] 1144275014505 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275014506 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275014507 active site 1144275014508 ATP binding site [chemical binding]; other site 1144275014509 substrate binding site [chemical binding]; other site 1144275014510 activation loop (A-loop); other site 1144275014511 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1144275014512 putative active site; other site 1144275014513 putative metal binding residues [ion binding]; other site 1144275014514 signature motif; other site 1144275014515 putative triphosphate binding site [ion binding]; other site 1144275014516 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1144275014517 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1144275014518 TMP-binding site; other site 1144275014519 ATP-binding site [chemical binding]; other site 1144275014520 Immunity protein Imm1; Region: Imm1; pfam14430 1144275014521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275014522 PhoD-like phosphatase; Region: PhoD; pfam09423 1144275014523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275014524 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275014525 active site 1144275014526 metal binding site [ion binding]; metal-binding site 1144275014527 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1144275014528 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1144275014529 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1144275014530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275014531 S-adenosylmethionine binding site [chemical binding]; other site 1144275014532 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1144275014533 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275014534 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1144275014535 protein binding site [polypeptide binding]; other site 1144275014536 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 1144275014537 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1144275014538 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275014539 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1144275014540 RNA/DNA hybrid binding site [nucleotide binding]; other site 1144275014541 active site 1144275014542 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1144275014543 NlpC/P60 family; Region: NLPC_P60; cl11438 1144275014544 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1144275014545 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1144275014546 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1144275014547 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1144275014548 active site 1144275014549 catalytic residues [active] 1144275014550 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275014551 active site 1144275014552 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1144275014553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275014554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275014555 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1144275014556 Helix-turn-helix domains; Region: HTH; cl00088 1144275014557 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1144275014558 active site 1144275014559 metal binding site [ion binding]; metal-binding site 1144275014560 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275014561 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275014562 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275014563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275014564 Helix-turn-helix domains; Region: HTH; cl00088 1144275014565 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275014566 putative effector binding pocket; other site 1144275014567 putative dimerization interface [polypeptide binding]; other site 1144275014568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275014569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1144275014570 active site 1144275014571 catalytic tetrad [active] 1144275014572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275014573 Helix-turn-helix domains; Region: HTH; cl00088 1144275014574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1144275014575 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275014576 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275014577 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 1144275014578 putative lyase; Provisional; Region: PRK09687 1144275014579 PemK-like protein; Region: PemK; cl00995 1144275014580 CAAX protease self-immunity; Region: Abi; cl00558 1144275014581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275014582 Helix-turn-helix domains; Region: HTH; cl00088 1144275014583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275014584 dimerization interface [polypeptide binding]; other site 1144275014585 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275014586 classical (c) SDRs; Region: SDR_c; cd05233 1144275014587 NAD(P) binding site [chemical binding]; other site 1144275014588 active site 1144275014589 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1144275014590 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1144275014591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275014592 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1144275014593 putative CheA interaction surface; other site 1144275014594 CHASE3 domain; Region: CHASE3; cl05000 1144275014595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275014596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275014597 dimer interface [polypeptide binding]; other site 1144275014598 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1144275014599 putative CheW interface [polypeptide binding]; other site 1144275014600 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275014601 putative binding surface; other site 1144275014602 active site 1144275014603 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1144275014604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014605 ATP binding site [chemical binding]; other site 1144275014606 G-X-G motif; other site 1144275014607 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1144275014608 Cupin domain; Region: Cupin_2; cl09118 1144275014609 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 1144275014610 CAS motifs; other site 1144275014611 active site 1144275014612 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1144275014613 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1144275014614 FMN binding site [chemical binding]; other site 1144275014615 active site 1144275014616 catalytic residues [active] 1144275014617 substrate binding site [chemical binding]; other site 1144275014618 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1144275014619 substrate binding pocket [chemical binding]; other site 1144275014620 substrate-Mg2+ binding site; other site 1144275014621 aspartate-rich region 1; other site 1144275014622 aspartate-rich region 2; other site 1144275014623 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1144275014624 Peptidase family C69; Region: Peptidase_C69; pfam03577 1144275014625 acetyl-CoA synthetase; Provisional; Region: PRK00174 1144275014626 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1144275014627 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275014628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275014629 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1144275014630 nudix motif; other site 1144275014631 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1144275014632 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1144275014633 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1144275014634 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1144275014635 putative substrate binding region [chemical binding]; other site 1144275014636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275014637 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1144275014638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014639 ATP binding site [chemical binding]; other site 1144275014640 Mg2+ binding site [ion binding]; other site 1144275014641 G-X-G motif; other site 1144275014642 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014644 active site 1144275014645 phosphorylation site [posttranslational modification] 1144275014646 intermolecular recognition site; other site 1144275014647 dimerization interface [polypeptide binding]; other site 1144275014648 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275014649 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275014650 dimer interface [polypeptide binding]; other site 1144275014651 phosphorylation site [posttranslational modification] 1144275014652 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275014653 ATP binding site [chemical binding]; other site 1144275014654 Mg2+ binding site [ion binding]; other site 1144275014655 G-X-G motif; other site 1144275014656 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275014657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014658 active site 1144275014659 phosphorylation site [posttranslational modification] 1144275014660 intermolecular recognition site; other site 1144275014661 dimerization interface [polypeptide binding]; other site 1144275014662 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1144275014663 MoaE interaction surface [polypeptide binding]; other site 1144275014664 MoeB interaction surface [polypeptide binding]; other site 1144275014665 thiocarboxylated glycine; other site 1144275014666 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1144275014667 MoaE homodimer interface [polypeptide binding]; other site 1144275014668 MoaD interaction [polypeptide binding]; other site 1144275014669 active site residues [active] 1144275014670 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1144275014671 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1144275014672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275014673 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1144275014674 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1144275014675 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1144275014676 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1144275014677 active site 1144275014678 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1144275014679 protein binding site [polypeptide binding]; other site 1144275014680 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1144275014681 protein binding site [polypeptide binding]; other site 1144275014682 RIP metalloprotease RseP; Region: TIGR00054 1144275014683 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1144275014684 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1144275014685 putative substrate binding region [chemical binding]; other site 1144275014686 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1144275014687 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1144275014688 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1144275014689 catalytic residue [active] 1144275014690 putative FPP diphosphate binding site; other site 1144275014691 putative FPP binding hydrophobic cleft; other site 1144275014692 dimer interface [polypeptide binding]; other site 1144275014693 putative IPP diphosphate binding site; other site 1144275014694 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275014695 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275014696 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275014697 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275014698 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275014699 active site 1144275014700 ATP binding site [chemical binding]; other site 1144275014701 substrate binding site [chemical binding]; other site 1144275014702 activation loop (A-loop); other site 1144275014703 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275014704 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275014705 active site 1144275014706 ATP binding site [chemical binding]; other site 1144275014707 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275014708 substrate binding site [chemical binding]; other site 1144275014709 activation loop (A-loop); other site 1144275014710 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1144275014711 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1144275014712 RNA binding surface [nucleotide binding]; other site 1144275014713 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275014714 active site 1144275014715 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1144275014716 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1144275014717 active site 1144275014718 DNA polymerase IV; Validated; Region: PRK02406 1144275014719 DNA binding site [nucleotide binding] 1144275014720 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1144275014721 poly(A) polymerase; Region: pcnB; TIGR01942 1144275014722 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1144275014723 active site 1144275014724 NTP binding site [chemical binding]; other site 1144275014725 metal binding triad [ion binding]; metal-binding site 1144275014726 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1144275014727 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1144275014728 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1144275014729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275014730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275014731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275014732 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275014733 metal ion-dependent adhesion site (MIDAS); other site 1144275014734 AIR carboxylase; Region: AIRC; cl00310 1144275014735 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1144275014736 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275014737 Uncharacterized conserved protein [Function unknown]; Region: COG3760 1144275014738 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1144275014739 putative deacylase active site [active] 1144275014740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1144275014741 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1144275014742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275014743 metal binding site [ion binding]; metal-binding site 1144275014744 active site 1144275014745 I-site; other site 1144275014746 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 1144275014747 PilZ domain; Region: PilZ; cl01260 1144275014748 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275014749 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1144275014750 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275014751 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1144275014752 Phosphotransferase enzyme family; Region: APH; pfam01636 1144275014753 putative active site [active] 1144275014754 putative substrate binding site [chemical binding]; other site 1144275014755 ATP binding site [chemical binding]; other site 1144275014756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275014757 TPR repeat; Region: TPR_11; pfam13414 1144275014758 binding surface 1144275014759 TPR motif; other site 1144275014760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275014761 ligand binding site [chemical binding]; other site 1144275014762 flexible hinge region; other site 1144275014763 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275014764 ligand binding site [chemical binding]; other site 1144275014765 flexible hinge region; other site 1144275014766 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275014767 phosphopeptide binding site; other site 1144275014768 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1144275014769 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1144275014770 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 1144275014771 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1144275014772 ParB-like nuclease domain; Region: ParBc; cl02129 1144275014773 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275014774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275014775 active site 1144275014776 phosphorylation site [posttranslational modification] 1144275014777 intermolecular recognition site; other site 1144275014778 dimerization interface [polypeptide binding]; other site 1144275014779 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275014780 Walker A motif; other site 1144275014781 ATP binding site [chemical binding]; other site 1144275014782 Walker B motif; other site 1144275014783 arginine finger; other site 1144275014784 Helix-turn-helix domains; Region: HTH; cl00088 1144275014785 Type IV pilus biogenesis; Region: Pilus_PilP; cl11837 1144275014786 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275014787 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1144275014788 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1144275014789 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1144275014790 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1144275014791 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1144275014792 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275014793 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1144275014794 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1144275014795 Walker A motif; other site 1144275014796 ATP binding site [chemical binding]; other site 1144275014797 Walker B motif; other site 1144275014798 type II secretion system protein F; Region: GspF; TIGR02120 1144275014799 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1144275014800 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1144275014801 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1144275014802 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1144275014803 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1144275014804 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1144275014805 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1144275014806 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1144275014807 general secretion pathway protein J; Validated; Region: PRK08808 1144275014808 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1144275014809 PilX N-terminal; Region: PilX_N; pfam14341 1144275014810 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1144275014811 Competence protein A; Region: Competence_A; pfam11104 1144275014812 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1144275014813 Cell division protein FtsA; Region: FtsA; cl11496 1144275014814 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1144275014815 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1144275014816 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275014817 phosphopeptide binding site; other site 1144275014818 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275014819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275014820 Walker A motif; other site 1144275014821 ATP binding site [chemical binding]; other site 1144275014822 Walker B motif; other site 1144275014823 arginine finger; other site 1144275014824 Helix-turn-helix domains; Region: HTH; cl00088 1144275014825 Amino acid permease; Region: AA_permease_2; pfam13520 1144275014826 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275014827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275014828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275014829 DNA binding residues [nucleotide binding] 1144275014830 Peptidase S46; Region: Peptidase_S46; pfam10459 1144275014831 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275014832 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1144275014833 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275014834 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1144275014835 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1144275014836 CAP-like domain; other site 1144275014837 active site 1144275014838 primary dimer interface [polypeptide binding]; other site 1144275014839 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1144275014840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275014841 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1144275014842 anchoring element; other site 1144275014843 dimer interface [polypeptide binding]; other site 1144275014844 ATP binding site [chemical binding]; other site 1144275014845 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1144275014846 active site 1144275014847 putative metal-binding site [ion binding]; other site 1144275014848 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1144275014849 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275014850 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275014851 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1144275014852 oligomer interface [polypeptide binding]; other site 1144275014853 tandem repeat interface [polypeptide binding]; other site 1144275014854 active site residues [active] 1144275014855 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1144275014856 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1144275014857 tandem repeat interface [polypeptide binding]; other site 1144275014858 oligomer interface [polypeptide binding]; other site 1144275014859 active site residues [active] 1144275014860 transcription termination factor Rho; Provisional; Region: PRK12608 1144275014861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275014862 Walker A motif; other site 1144275014863 ATP binding site [chemical binding]; other site 1144275014864 Walker B motif; other site 1144275014865 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275014866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275014867 Walker A motif; other site 1144275014868 ATP binding site [chemical binding]; other site 1144275014869 Walker B motif; other site 1144275014870 arginine finger; other site 1144275014871 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1144275014872 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275014873 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275014874 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 1144275014875 dimer interface [polypeptide binding]; other site 1144275014876 substrate binding site [chemical binding]; other site 1144275014877 metal binding sites [ion binding]; metal-binding site 1144275014878 Integral membrane protein DUF95; Region: DUF95; cl00572 1144275014879 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275014880 active site 1144275014881 metal binding site [ion binding]; metal-binding site 1144275014882 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275014883 HEAT repeats; Region: HEAT_2; pfam13646 1144275014884 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275014885 ligand binding site [chemical binding]; other site 1144275014886 RDD family; Region: RDD; cl00746 1144275014887 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275014888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275014889 TPR repeat; Region: TPR_11; pfam13414 1144275014890 binding surface 1144275014891 TPR motif; other site 1144275014892 TPR repeat; Region: TPR_11; pfam13414 1144275014893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275014894 binding surface 1144275014895 TPR motif; other site 1144275014896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275014897 TPR motif; other site 1144275014898 binding surface 1144275014899 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275014900 phosphopeptide binding site; other site 1144275014901 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275014902 phosphopeptide binding site; other site 1144275014903 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1144275014904 FHIPEP family; Region: FHIPEP; pfam00771 1144275014905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275014906 TPR motif; other site 1144275014907 binding surface 1144275014908 TPR repeat; Region: TPR_11; pfam13414 1144275014909 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1144275014910 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1144275014911 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1144275014912 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1144275014913 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1144275014914 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1144275014915 FliP family; Region: FliP; cl00593 1144275014916 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1144275014917 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1144275014918 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1144275014919 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1144275014920 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1144275014921 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1144275014922 Walker A motif/ATP binding site; other site 1144275014923 Walker B motif; other site 1144275014924 Flagellar assembly protein FliH; Region: FliH; pfam02108 1144275014925 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1144275014926 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1144275014927 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1144275014928 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275014929 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275014930 DNA binding residues [nucleotide binding] 1144275014931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275014932 binding surface 1144275014933 TPR motif; other site 1144275014934 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1144275014935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275014936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275014937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1144275014938 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1144275014939 LVIVD repeat; Region: LVIVD; pfam08309 1144275014940 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275014941 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275014942 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275014943 CotH protein; Region: CotH; pfam08757 1144275014944 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1144275014945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275014946 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1144275014947 Transglycosylase; Region: Transgly; cl07896 1144275014948 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275014949 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1144275014950 Bacterial Ig-like domain; Region: Big_5; cl01012 1144275014951 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1144275014952 MG2 domain; Region: A2M_N; pfam01835 1144275014953 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1144275014954 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1144275014955 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1144275014956 surface patch; other site 1144275014957 thioester region; other site 1144275014958 specificity defining residues; other site 1144275014959 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1144275014960 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1144275014961 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1144275014962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1144275014963 RNA binding surface [nucleotide binding]; other site 1144275014964 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1144275014965 active site 1144275014966 uracil binding [chemical binding]; other site 1144275014967 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1144275014968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275014969 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1144275014970 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275014971 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1144275014972 elongation factor G; Reviewed; Region: PRK12740 1144275014973 G1 box; other site 1144275014974 putative GEF interaction site [polypeptide binding]; other site 1144275014975 GTP/Mg2+ binding site [chemical binding]; other site 1144275014976 Switch I region; other site 1144275014977 G2 box; other site 1144275014978 G3 box; other site 1144275014979 Switch II region; other site 1144275014980 G4 box; other site 1144275014981 G5 box; other site 1144275014982 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 1144275014983 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1144275014984 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 1144275014985 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1144275014986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275014987 Walker A/P-loop; other site 1144275014988 ATP binding site [chemical binding]; other site 1144275014989 Q-loop/lid; other site 1144275014990 ABC transporter signature motif; other site 1144275014991 Walker B; other site 1144275014992 D-loop; other site 1144275014993 H-loop/switch region; other site 1144275014994 ABC transporter; Region: ABC_tran_2; pfam12848 1144275014995 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1144275014996 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 1144275014997 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275014998 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275014999 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1144275015000 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1144275015001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275015002 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275015003 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275015004 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015005 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015006 active site 1144275015007 ATP binding site [chemical binding]; other site 1144275015008 substrate binding site [chemical binding]; other site 1144275015009 activation loop (A-loop); other site 1144275015010 TfuA-like protein; Region: TfuA; pfam07812 1144275015011 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 1144275015012 YcaO-like family; Region: YcaO; pfam02624 1144275015013 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1144275015014 catalytic triad [active] 1144275015015 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275015016 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275015017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275015018 DNA binding residues [nucleotide binding] 1144275015019 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1144275015020 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1144275015021 catalytic residues [active] 1144275015022 dimer interface [polypeptide binding]; other site 1144275015023 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1144275015024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015025 Walker A/P-loop; other site 1144275015026 ATP binding site [chemical binding]; other site 1144275015027 Q-loop/lid; other site 1144275015028 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015029 ABC transporter signature motif; other site 1144275015030 Walker B; other site 1144275015031 D-loop; other site 1144275015032 H-loop/switch region; other site 1144275015033 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015034 Walker A/P-loop; other site 1144275015035 ATP binding site [chemical binding]; other site 1144275015036 Q-loop/lid; other site 1144275015037 ABC transporter signature motif; other site 1144275015038 Walker B; other site 1144275015039 D-loop; other site 1144275015040 H-loop/switch region; other site 1144275015041 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1144275015042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015043 Walker A/P-loop; other site 1144275015044 ATP binding site [chemical binding]; other site 1144275015045 Q-loop/lid; other site 1144275015046 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1144275015047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015048 Walker A/P-loop; other site 1144275015049 ATP binding site [chemical binding]; other site 1144275015050 Q-loop/lid; other site 1144275015051 ABC transporter signature motif; other site 1144275015052 Walker B; other site 1144275015053 D-loop; other site 1144275015054 H-loop/switch region; other site 1144275015055 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275015056 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275015057 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275015058 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1144275015059 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1144275015060 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275015061 active site 1144275015062 Zn binding site [ion binding]; other site 1144275015063 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1144275015064 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1144275015065 active site 1144275015066 metal binding site [ion binding]; metal-binding site 1144275015067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275015068 SET domain; Region: SET; cl02566 1144275015069 Protein of unknown function (DUF423); Region: DUF423; cl01008 1144275015070 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1144275015071 active site 1144275015072 SUMO-1 interface [polypeptide binding]; other site 1144275015073 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 1144275015074 active site 1144275015075 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1144275015076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275015077 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275015078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1144275015079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275015080 Coenzyme A binding pocket [chemical binding]; other site 1144275015081 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1144275015082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275015083 active site 1144275015084 HIGH motif; other site 1144275015085 nucleotide binding site [chemical binding]; other site 1144275015086 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1144275015087 KMSKS motif; other site 1144275015088 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1144275015089 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1144275015090 putative ADP-binding pocket [chemical binding]; other site 1144275015091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275015092 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275015093 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275015094 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1144275015095 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275015096 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1144275015097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275015098 active site 1144275015099 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1144275015100 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1144275015101 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275015102 catalytic residue [active] 1144275015103 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275015104 HYR domain; Region: HYR; pfam02494 1144275015105 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275015106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275015107 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275015108 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1144275015109 active site 1144275015110 dimer interface [polypeptide binding]; other site 1144275015111 motif 1; other site 1144275015112 motif 2; other site 1144275015113 motif 3; other site 1144275015114 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1144275015115 anticodon binding site; other site 1144275015116 FOG: CBS domain [General function prediction only]; Region: COG0517 1144275015117 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1144275015118 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1144275015119 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1144275015120 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275015121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275015122 DNA-binding site [nucleotide binding]; DNA binding site 1144275015123 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1144275015124 Glyco_18 domain; Region: Glyco_18; smart00636 1144275015125 active site 1144275015126 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1144275015127 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1144275015128 dimerization interface [polypeptide binding]; other site 1144275015129 ATP binding site [chemical binding]; other site 1144275015130 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1144275015131 dimerization interface [polypeptide binding]; other site 1144275015132 ATP binding site [chemical binding]; other site 1144275015133 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1144275015134 putative active site [active] 1144275015135 catalytic triad [active] 1144275015136 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275015137 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275015138 active site 1144275015139 Zn binding site [ion binding]; other site 1144275015140 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275015141 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275015142 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275015143 dinuclear metal binding motif [ion binding]; other site 1144275015144 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1144275015145 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1144275015146 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1144275015147 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275015148 xanthine dehydrogenase; Region: PLN02906 1144275015149 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1144275015150 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1144275015151 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1144275015152 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275015153 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 1144275015154 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1144275015155 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 1144275015156 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1144275015157 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015158 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015159 Condensation domain; Region: Condensation; pfam00668 1144275015160 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275015161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275015162 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015163 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015164 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015165 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275015166 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1144275015167 active site 1144275015168 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1144275015169 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275015170 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1144275015171 putative NADP binding site [chemical binding]; other site 1144275015172 active site 1144275015173 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015174 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1144275015175 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275015176 active site 1144275015177 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275015178 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1144275015179 putative NADP binding site [chemical binding]; other site 1144275015180 active site 1144275015181 peptide synthase; Provisional; Region: PRK12316 1144275015182 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015183 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 1144275015184 Condensation domain; Region: Condensation; pfam00668 1144275015185 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1144275015186 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275015187 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015188 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015189 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015190 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1144275015191 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1144275015192 active site 1144275015193 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1144275015194 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1144275015195 putative NADP binding site [chemical binding]; other site 1144275015196 active site 1144275015197 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015198 H+ Antiporter protein; Region: 2A0121; TIGR00900 1144275015199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275015200 putative substrate translocation pore; other site 1144275015201 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1144275015202 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275015203 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1144275015204 active site 1144275015205 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1144275015206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275015207 ligand binding site [chemical binding]; other site 1144275015208 flexible hinge region; other site 1144275015209 Helix-turn-helix domains; Region: HTH; cl00088 1144275015210 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275015211 phosphopeptide binding site; other site 1144275015212 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275015213 GAF domain; Region: GAF; cl15785 1144275015214 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1144275015215 cyclase homology domain; Region: CHD; cd07302 1144275015216 nucleotidyl binding site; other site 1144275015217 metal binding site [ion binding]; metal-binding site 1144275015218 dimer interface [polypeptide binding]; other site 1144275015219 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015220 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015221 active site 1144275015222 ATP binding site [chemical binding]; other site 1144275015223 substrate binding site [chemical binding]; other site 1144275015224 activation loop (A-loop); other site 1144275015225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275015226 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275015227 active site 1144275015228 phosphorylation site [posttranslational modification] 1144275015229 intermolecular recognition site; other site 1144275015230 dimerization interface [polypeptide binding]; other site 1144275015231 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1144275015232 cyclase homology domain; Region: CHD; cd07302 1144275015233 nucleotidyl binding site; other site 1144275015234 metal binding site [ion binding]; metal-binding site 1144275015235 dimer interface [polypeptide binding]; other site 1144275015236 NAD-dependent deacetylase; Provisional; Region: PRK05333 1144275015237 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1144275015238 NAD+ binding site [chemical binding]; other site 1144275015239 substrate binding site [chemical binding]; other site 1144275015240 Zn binding site [ion binding]; other site 1144275015241 Putative zinc-finger; Region: zf-HC2; cl15806 1144275015242 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015243 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015244 active site 1144275015245 ATP binding site [chemical binding]; other site 1144275015246 substrate binding site [chemical binding]; other site 1144275015247 activation loop (A-loop); other site 1144275015248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275015250 binding surface 1144275015251 TPR motif; other site 1144275015252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015253 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275015255 binding surface 1144275015256 TPR motif; other site 1144275015257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015259 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1144275015260 Amidase; Region: Amidase; cl11426 1144275015261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1144275015262 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275015263 ATP binding site [chemical binding]; other site 1144275015264 polyadenylate binding protein, human types 1, 2, 3, 4 family; Region: PABP-1234; TIGR01628 1144275015265 transcription termination factor Rho; Provisional; Region: PRK12678 1144275015266 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275015267 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275015268 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1144275015269 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1144275015270 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275015271 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1144275015272 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1144275015273 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1144275015274 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275015275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275015276 catalytic residue [active] 1144275015277 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1144275015278 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1144275015279 EamA-like transporter family; Region: EamA; cl01037 1144275015280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015281 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275015282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015283 NAD(P) binding site [chemical binding]; other site 1144275015284 active site 1144275015285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275015286 Helix-turn-helix domains; Region: HTH; cl00088 1144275015287 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1144275015288 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275015289 putative catalytic site [active] 1144275015290 putative metal binding site [ion binding]; other site 1144275015291 putative phosphate binding site [ion binding]; other site 1144275015292 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275015293 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1144275015294 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 1144275015295 Fic family protein [Function unknown]; Region: COG3177 1144275015296 Fic/DOC family; Region: Fic; cl00960 1144275015297 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1144275015298 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1144275015299 ATP binding site [chemical binding]; other site 1144275015300 Mg++ binding site [ion binding]; other site 1144275015301 motif III; other site 1144275015302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275015303 nucleotide binding region [chemical binding]; other site 1144275015304 ATP-binding site [chemical binding]; other site 1144275015305 DbpA RNA binding domain; Region: DbpA; pfam03880 1144275015306 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1144275015307 Helix-turn-helix domains; Region: HTH; cl00088 1144275015308 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1144275015309 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1144275015310 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275015311 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275015312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275015313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275015314 DNA binding residues [nucleotide binding] 1144275015315 H+ Antiporter protein; Region: 2A0121; TIGR00900 1144275015316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275015317 putative substrate translocation pore; other site 1144275015318 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1144275015319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275015320 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 1144275015321 ATP adenylyltransferase; Region: ATP_transf; pfam09830 1144275015322 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275015323 TIGR01666 family membrane protein; Region: YCCS 1144275015324 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1144275015325 SGT1, suppressor of G2 allele of SKP1; Provisional; Region: PLN03088 1144275015326 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1144275015327 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275015328 active site 1144275015329 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1144275015330 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275015331 putative NAD(P) binding site [chemical binding]; other site 1144275015332 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1144275015333 triacylglycerol lipase; Region: PLN02872 1144275015334 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275015335 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275015336 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275015337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015338 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275015339 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015340 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015341 active site 1144275015342 ATP binding site [chemical binding]; other site 1144275015343 substrate binding site [chemical binding]; other site 1144275015344 activation loop (A-loop); other site 1144275015345 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275015347 active site 1144275015348 ATP binding site [chemical binding]; other site 1144275015349 substrate binding site [chemical binding]; other site 1144275015350 activation loop (A-loop); other site 1144275015351 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015352 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015353 active site 1144275015354 ATP binding site [chemical binding]; other site 1144275015355 substrate binding site [chemical binding]; other site 1144275015356 activation loop (A-loop); other site 1144275015357 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1144275015358 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1144275015359 FMN binding site [chemical binding]; other site 1144275015360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275015361 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1144275015362 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275015363 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1144275015364 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275015365 phosphopeptide binding site; other site 1144275015366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275015367 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275015368 Walker A motif; other site 1144275015369 ATP binding site [chemical binding]; other site 1144275015370 Walker B motif; other site 1144275015371 arginine finger; other site 1144275015372 Helix-turn-helix domains; Region: HTH; cl00088 1144275015373 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015374 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275015375 active site 1144275015376 ATP binding site [chemical binding]; other site 1144275015377 substrate binding site [chemical binding]; other site 1144275015378 activation loop (A-loop); other site 1144275015379 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015380 Protein kinase domain; Region: Pkinase; pfam00069 1144275015381 active site 1144275015382 ATP binding site [chemical binding]; other site 1144275015383 substrate binding site [chemical binding]; other site 1144275015384 activation loop (A-loop); other site 1144275015385 Predicted ATPase [General function prediction only]; Region: COG3899 1144275015386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275015387 TPR motif; other site 1144275015388 binding surface 1144275015389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015390 OPT oligopeptide transporter protein; Region: OPT; cl14607 1144275015391 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1144275015392 protein-splicing catalytic site; other site 1144275015393 thioester formation/cholesterol transfer; other site 1144275015394 HipA N-terminal domain; Region: Couple_hipA; cl11853 1144275015395 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1144275015396 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1144275015397 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1144275015398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275015399 S-adenosylmethionine binding site [chemical binding]; other site 1144275015400 Protein of unknown function DUF262; Region: DUF262; cl14890 1144275015401 Protein of unknown function DUF262; Region: DUF262; cl14890 1144275015402 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 1144275015403 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 1144275015404 active site 1144275015405 trehalose synthase; Region: treS_nterm; TIGR02456 1144275015406 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1144275015407 active site 1144275015408 catalytic site [active] 1144275015409 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1144275015410 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1144275015411 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 1144275015412 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275015413 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015414 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015415 active site 1144275015416 ATP binding site [chemical binding]; other site 1144275015417 substrate binding site [chemical binding]; other site 1144275015418 activation loop (A-loop); other site 1144275015419 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015420 active site 1144275015421 ATP binding site [chemical binding]; other site 1144275015422 substrate binding site [chemical binding]; other site 1144275015423 activation loop (A-loop); other site 1144275015424 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1144275015425 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1144275015426 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275015427 ATP binding site [chemical binding]; other site 1144275015428 putative Mg++ binding site [ion binding]; other site 1144275015429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275015430 nucleotide binding region [chemical binding]; other site 1144275015431 ATP-binding site [chemical binding]; other site 1144275015432 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1144275015433 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275015434 N-terminal plug; other site 1144275015435 ligand-binding site [chemical binding]; other site 1144275015436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275015437 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275015438 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275015439 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015440 active site 1144275015441 ATP binding site [chemical binding]; other site 1144275015442 substrate binding site [chemical binding]; other site 1144275015443 activation loop (A-loop); other site 1144275015444 metabolite-proton symporter; Region: 2A0106; TIGR00883 1144275015445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275015446 circadian clock protein KaiC; Reviewed; Region: PRK09302 1144275015447 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015449 Walker A motif; other site 1144275015450 ATP binding site [chemical binding]; other site 1144275015451 Walker B motif; other site 1144275015452 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275015453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275015454 active site 1144275015455 phosphorylation site [posttranslational modification] 1144275015456 intermolecular recognition site; other site 1144275015457 dimerization interface [polypeptide binding]; other site 1144275015458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275015459 dimer interface [polypeptide binding]; other site 1144275015460 phosphorylation site [posttranslational modification] 1144275015461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275015462 ATP binding site [chemical binding]; other site 1144275015463 Mg2+ binding site [ion binding]; other site 1144275015464 G-X-G motif; other site 1144275015465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275015466 H+ Antiporter protein; Region: 2A0121; TIGR00900 1144275015467 putative substrate translocation pore; other site 1144275015468 peptide synthase; Provisional; Region: PRK12467 1144275015469 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275015470 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015471 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015472 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275015473 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015474 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015475 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015476 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1144275015477 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1144275015478 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015479 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015480 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1144275015481 Glyco_18 domain; Region: Glyco_18; smart00636 1144275015482 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1144275015483 active site 1144275015484 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275015485 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275015486 putative sugar binding sites [chemical binding]; other site 1144275015487 Q-X-W motif; other site 1144275015488 Protein of unknown function (DUF466); Region: DUF466; cl01082 1144275015489 carbon starvation protein A; Provisional; Region: PRK15015 1144275015490 Carbon starvation protein CstA; Region: CstA; pfam02554 1144275015491 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1144275015492 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1144275015493 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1144275015494 active site triad [active] 1144275015495 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1144275015496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015497 Helix-turn-helix domains; Region: HTH; cl00088 1144275015498 WYL domain; Region: WYL; cl14852 1144275015499 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1144275015500 DNA polymerase type-B family; Region: POLBc; smart00486 1144275015501 active site 1144275015502 catalytic site [active] 1144275015503 substrate binding site [chemical binding]; other site 1144275015504 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both synthetic; Region: POLBc; cl10023 1144275015505 active site 1144275015506 metal-binding site 1144275015507 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; cl07913 1144275015508 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1144275015509 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275015510 putative acyl-acceptor binding pocket; other site 1144275015511 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015512 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275015513 Predicted membrane protein [Function unknown]; Region: COG4648 1144275015514 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1144275015515 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275015516 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275015517 active site 2 [active] 1144275015518 active site 1 [active] 1144275015519 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1144275015520 Ligand binding site; other site 1144275015521 Putative Catalytic site; other site 1144275015522 DXD motif; other site 1144275015523 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1144275015524 putative acyl-acceptor binding pocket; other site 1144275015525 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1144275015526 active sites [active] 1144275015527 tetramer interface [polypeptide binding]; other site 1144275015528 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275015529 active site 1144275015530 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 1144275015531 Predicted exporter [General function prediction only]; Region: COG4258 1144275015532 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1144275015533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015534 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1144275015535 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1144275015536 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275015537 active site 1144275015538 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1144275015539 putative active site 1 [active] 1144275015540 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275015541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015542 NAD(P) binding site [chemical binding]; other site 1144275015543 active site 1144275015544 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1144275015545 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1144275015546 dimer interface [polypeptide binding]; other site 1144275015547 active site 1144275015548 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1144275015549 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1144275015550 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1144275015551 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275015552 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1144275015553 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1144275015554 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1144275015555 active site 1144275015556 Zn binding site [ion binding]; other site 1144275015557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275015558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275015559 Helix-turn-helix domains; Region: HTH; cl00088 1144275015560 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1144275015561 putative substrate binding pocket [chemical binding]; other site 1144275015562 putative dimerization interface [polypeptide binding]; other site 1144275015563 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 1144275015564 catalytic triad [active] 1144275015565 putative active site [active] 1144275015566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275015567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1144275015568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275015569 Helix-turn-helix domains; Region: HTH; cl00088 1144275015570 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1144275015571 catalytic residue [active] 1144275015572 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1144275015573 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275015574 Histidine kinase; Region: His_kinase; pfam06580 1144275015575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275015576 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1144275015577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275015578 active site 1144275015579 phosphorylation site [posttranslational modification] 1144275015580 intermolecular recognition site; other site 1144275015581 dimerization interface [polypeptide binding]; other site 1144275015582 LytTr DNA-binding domain; Region: LytTR; cl04498 1144275015583 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1144275015584 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1144275015585 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1144275015586 active site 1144275015587 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275015588 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1144275015589 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275015590 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275015591 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275015592 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1144275015593 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1144275015594 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275015595 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1144275015596 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275015597 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 1144275015598 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1144275015599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275015600 elongation factor G; Reviewed; Region: PRK00007 1144275015601 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1144275015602 G1 box; other site 1144275015603 putative GEF interaction site [polypeptide binding]; other site 1144275015604 GTP/Mg2+ binding site [chemical binding]; other site 1144275015605 Switch I region; other site 1144275015606 G2 box; other site 1144275015607 G3 box; other site 1144275015608 Switch II region; other site 1144275015609 G4 box; other site 1144275015610 G5 box; other site 1144275015611 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1144275015612 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1144275015613 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1144275015614 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275015615 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275015616 active site 1144275015617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275015618 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275015619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275015620 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1144275015621 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1144275015622 Citrate synthase; Region: Citrate_synt; pfam00285 1144275015623 dimer interface [polypeptide binding]; other site 1144275015624 active site 1144275015625 oxalacetate/citrate binding site [chemical binding]; other site 1144275015626 citrylCoA binding site [chemical binding]; other site 1144275015627 coenzyme A binding site [chemical binding]; other site 1144275015628 catalytic triad [active] 1144275015629 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275015630 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 1144275015631 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1144275015632 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275015633 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275015634 hypothetical protein; Validated; Region: PRK09169 1144275015635 Predicted esterase [General function prediction only]; Region: COG0400 1144275015636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275015637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275015638 Coenzyme A binding pocket [chemical binding]; other site 1144275015639 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275015640 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1144275015641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275015642 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1144275015643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275015644 putative substrate translocation pore; other site 1144275015645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275015646 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275015647 putative acyltransferase; Provisional; Region: PRK05790 1144275015648 Helix-turn-helix domains; Region: HTH; cl00088 1144275015649 Cupin domain; Region: Cupin_2; cl09118 1144275015650 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1144275015651 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1144275015652 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1144275015653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275015654 S-adenosylmethionine binding site [chemical binding]; other site 1144275015655 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1144275015656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275015657 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1144275015658 active site 1144275015659 metal binding site [ion binding]; metal-binding site 1144275015660 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 1144275015661 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1144275015662 hypothetical protein; Provisional; Region: PHA02664 1144275015663 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275015664 active site 1144275015665 Zn binding site [ion binding]; other site 1144275015666 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1144275015667 active site 1144275015668 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 1144275015669 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1144275015670 putative active site [active] 1144275015671 metal binding site [ion binding]; metal-binding site 1144275015672 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1144275015673 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275015674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1144275015675 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275015676 Walker A/P-loop; other site 1144275015677 ATP binding site [chemical binding]; other site 1144275015678 Q-loop/lid; other site 1144275015679 ABC transporter signature motif; other site 1144275015680 Walker B; other site 1144275015681 D-loop; other site 1144275015682 H-loop/switch region; other site 1144275015683 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275015684 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275015685 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275015686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275015687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275015688 dimer interface [polypeptide binding]; other site 1144275015689 phosphorylation site [posttranslational modification] 1144275015690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1144275015691 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275015692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275015693 active site 1144275015694 phosphorylation site [posttranslational modification] 1144275015695 intermolecular recognition site; other site 1144275015696 dimerization interface [polypeptide binding]; other site 1144275015697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275015698 Walker A motif; other site 1144275015699 ATP binding site [chemical binding]; other site 1144275015700 Walker B motif; other site 1144275015701 arginine finger; other site 1144275015702 Helix-turn-helix domains; Region: HTH; cl00088 1144275015703 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 1144275015704 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1144275015705 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275015706 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1144275015707 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1144275015708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275015709 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1144275015710 YceI-like domain; Region: YceI; cl01001 1144275015711 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1144275015712 PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921 1144275015713 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275015714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1144275015715 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1144275015716 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1144275015717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275015718 S-adenosylmethionine binding site [chemical binding]; other site 1144275015719 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1144275015720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275015721 DNA-binding site [nucleotide binding]; DNA binding site 1144275015722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275015723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275015724 homodimer interface [polypeptide binding]; other site 1144275015725 catalytic residue [active] 1144275015726 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1144275015727 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1144275015728 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1144275015729 Walker A/P-loop; other site 1144275015730 ATP binding site [chemical binding]; other site 1144275015731 Q-loop/lid; other site 1144275015732 ABC transporter signature motif; other site 1144275015733 Walker B; other site 1144275015734 D-loop; other site 1144275015735 H-loop/switch region; other site 1144275015736 NIL domain; Region: NIL; cl09633 1144275015737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275015738 dimer interface [polypeptide binding]; other site 1144275015739 conserved gate region; other site 1144275015740 ABC-ATPase subunit interface; other site 1144275015741 NMT1-like family; Region: NMT1_2; cl15260 1144275015742 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 1144275015743 active site flap/lid [active] 1144275015744 nucleophilic elbow; other site 1144275015745 serine endoprotease; Provisional; Region: PRK10139 1144275015746 Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441 1144275015747 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275015748 TetR family transcriptional regulator; Provisional; Region: PRK14996 1144275015749 Helix-turn-helix domains; Region: HTH; cl00088 1144275015750 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1144275015751 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1144275015752 calcium binding site 2 [ion binding]; other site 1144275015753 active site 1144275015754 catalytic triad [active] 1144275015755 calcium binding site 1 [ion binding]; other site 1144275015756 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1144275015757 EamA-like transporter family; Region: EamA; cl01037 1144275015758 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1144275015759 Integrase core domain; Region: rve; cl01316 1144275015760 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275015761 active site 1144275015762 trigger factor; Region: tig; TIGR00115 1144275015763 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275015764 Putative zinc-finger; Region: zf-HC2; cl15806 1144275015765 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015766 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015767 active site 1144275015768 ATP binding site [chemical binding]; other site 1144275015769 substrate binding site [chemical binding]; other site 1144275015770 activation loop (A-loop); other site 1144275015771 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275015773 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1144275015774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275015775 DNA binding residues [nucleotide binding] 1144275015776 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015777 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015778 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1144275015779 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1144275015780 metal binding site [ion binding]; metal-binding site 1144275015781 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1144275015782 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275015783 active site 1144275015784 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 1144275015785 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1144275015786 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1144275015787 active site 1144275015788 zinc binding site [ion binding]; other site 1144275015789 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1144275015790 HNH endonuclease; Region: HNH_3; pfam13392 1144275015791 Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Region: COG5222 1144275015792 GatB domain; Region: GatB_Yqey; cl11497 1144275015793 CotH protein; Region: CotH; pfam08757 1144275015794 TIGR03118 family protein; Region: PEPCTERM_chp_1 1144275015795 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1144275015796 conserved cys residue [active] 1144275015797 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1144275015798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275015799 S-adenosylmethionine binding site [chemical binding]; other site 1144275015800 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1144275015801 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1144275015802 active site 1144275015803 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015804 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015805 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015806 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015807 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275015808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275015809 non-specific DNA binding site [nucleotide binding]; other site 1144275015810 salt bridge; other site 1144275015811 sequence-specific DNA binding site [nucleotide binding]; other site 1144275015812 Domain of unknown function (DUF955); Region: DUF955; cl01076 1144275015813 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1144275015814 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275015815 putative NAD(P) binding site [chemical binding]; other site 1144275015816 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275015817 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275015818 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275015819 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275015820 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275015821 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275015822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275015823 ligand binding site [chemical binding]; other site 1144275015824 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 1144275015825 transcriptional regulator; Provisional; Region: PRK10632 1144275015826 Helix-turn-helix domains; Region: HTH; cl00088 1144275015827 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1144275015828 putative effector binding pocket; other site 1144275015829 dimerization interface [polypeptide binding]; other site 1144275015830 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1144275015831 catalytic residues [active] 1144275015832 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1144275015833 catalytic residues [active] 1144275015834 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1144275015835 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275015836 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275015837 protein binding site [polypeptide binding]; other site 1144275015838 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1144275015839 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1144275015840 active site 1144275015841 ATP binding site [chemical binding]; other site 1144275015842 substrate binding site [chemical binding]; other site 1144275015843 adenylosuccinate lyase; Provisional; Region: PRK07492 1144275015844 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1144275015845 tetramer interface [polypeptide binding]; other site 1144275015846 active site 1144275015847 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1144275015848 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1144275015849 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015850 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015851 active site 1144275015852 ATP binding site [chemical binding]; other site 1144275015853 substrate binding site [chemical binding]; other site 1144275015854 activation loop (A-loop); other site 1144275015855 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275015856 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1144275015857 trimer interface [polypeptide binding]; other site 1144275015858 active site 1144275015859 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275015860 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1144275015861 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1144275015862 RNase E interface [polypeptide binding]; other site 1144275015863 trimer interface [polypeptide binding]; other site 1144275015864 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1144275015865 RNase E interface [polypeptide binding]; other site 1144275015866 trimer interface [polypeptide binding]; other site 1144275015867 active site 1144275015868 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1144275015869 putative nucleic acid binding region [nucleotide binding]; other site 1144275015870 G-X-X-G motif; other site 1144275015871 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1144275015872 RNA binding site [nucleotide binding]; other site 1144275015873 domain interface; other site 1144275015874 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1144275015875 16S/18S rRNA binding site [nucleotide binding]; other site 1144275015876 S13e-L30e interaction site [polypeptide binding]; other site 1144275015877 25S rRNA binding site [nucleotide binding]; other site 1144275015878 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1144275015879 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1144275015880 RNA binding site [nucleotide binding]; other site 1144275015881 active site 1144275015882 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1144275015883 Ribosome-binding factor A; Region: RBFA; cl00542 1144275015884 Protein of unknown function (DUF503); Region: DUF503; cl00669 1144275015885 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1144275015886 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1144275015887 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1144275015888 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1144275015889 G1 box; other site 1144275015890 putative GEF interaction site [polypeptide binding]; other site 1144275015891 GTP/Mg2+ binding site [chemical binding]; other site 1144275015892 Switch I region; other site 1144275015893 G2 box; other site 1144275015894 G3 box; other site 1144275015895 Switch II region; other site 1144275015896 G4 box; other site 1144275015897 G5 box; other site 1144275015898 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1144275015899 Translation-initiation factor 2; Region: IF-2; pfam11987 1144275015900 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1144275015901 NusA N-terminal domain; Region: NusA_N; pfam08529 1144275015902 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1144275015903 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1144275015904 RNA binding site [nucleotide binding]; other site 1144275015905 homodimer interface [polypeptide binding]; other site 1144275015906 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1144275015907 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1144275015908 G-X-X-G motif; other site 1144275015909 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1144275015910 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1144275015911 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1144275015912 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 1144275015913 Sm1 motif; other site 1144275015914 predicted subunit interaction site [polypeptide binding]; other site 1144275015915 RNA binding pocket [nucleotide binding]; other site 1144275015916 Sm2 motif; other site 1144275015917 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1144275015918 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1144275015919 putative active site [active] 1144275015920 catalytic triad [active] 1144275015921 dimer interface [polypeptide binding]; other site 1144275015922 FecR protein; Region: FecR; pfam04773 1144275015923 Cache domain; Region: Cache_1; pfam02743 1144275015924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275015925 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275015926 Zn2+ binding site [ion binding]; other site 1144275015927 Mg2+ binding site [ion binding]; other site 1144275015928 Protein of unknown function (DUF971); Region: DUF971; cl01414 1144275015929 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275015930 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275015931 active site 1144275015932 ATP binding site [chemical binding]; other site 1144275015933 substrate binding site [chemical binding]; other site 1144275015934 activation loop (A-loop); other site 1144275015935 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1144275015936 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275015937 Stringent starvation protein B; Region: SspB; cl01120 1144275015938 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1144275015939 SmpB-tmRNA interface; other site 1144275015940 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1144275015941 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1144275015942 active site 1144275015943 ATP-binding site [chemical binding]; other site 1144275015944 pantoate-binding site; other site 1144275015945 HXXH motif; other site 1144275015946 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1144275015947 oligomerization interface [polypeptide binding]; other site 1144275015948 active site 1144275015949 metal binding site [ion binding]; metal-binding site 1144275015950 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1144275015951 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1144275015952 Substrate-binding site [chemical binding]; other site 1144275015953 Substrate specificity [chemical binding]; other site 1144275015954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275015955 S-adenosylmethionine binding site [chemical binding]; other site 1144275015956 UGMP family protein; Validated; Region: PRK09604 1144275015957 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1144275015958 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275015959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275015960 active site 1144275015961 phosphorylation site [posttranslational modification] 1144275015962 intermolecular recognition site; other site 1144275015963 dimerization interface [polypeptide binding]; other site 1144275015964 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275015965 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1144275015966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275015967 binding surface 1144275015968 TPR repeat; Region: TPR_11; pfam13414 1144275015969 TPR motif; other site 1144275015970 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275015971 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275015972 HSP70 interaction site [polypeptide binding]; other site 1144275015973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275015974 binding surface 1144275015975 TPR motif; other site 1144275015976 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1144275015977 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 1144275015978 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1144275015979 active site 1144275015980 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1144275015981 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1144275015982 Substrate binding site; other site 1144275015983 metal-binding site 1144275015984 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1144275015985 Phosphotransferase enzyme family; Region: APH; pfam01636 1144275015986 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1144275015987 active site 1144275015988 ATP binding site [chemical binding]; other site 1144275015989 substrate binding site [chemical binding]; other site 1144275015990 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1144275015991 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1144275015992 dimer interface [polypeptide binding]; other site 1144275015993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275015994 catalytic residue [active] 1144275015995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1144275015996 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1144275015997 putative active site [active] 1144275015998 putative catalytic site [active] 1144275015999 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1144275016000 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275016001 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275016002 active site 1144275016003 metal binding site [ion binding]; metal-binding site 1144275016004 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1144275016005 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1144275016006 homodimer interface [polypeptide binding]; other site 1144275016007 substrate-cofactor binding pocket; other site 1144275016008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275016009 catalytic residue [active] 1144275016010 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1144275016011 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275016012 substrate binding site [chemical binding]; other site 1144275016013 oxyanion hole (OAH) forming residues; other site 1144275016014 trimer interface [polypeptide binding]; other site 1144275016015 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1144275016016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275016017 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275016018 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275016019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275016020 FecR protein; Region: FecR; pfam04773 1144275016021 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1144275016022 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1144275016023 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1144275016024 putative RNA binding site [nucleotide binding]; other site 1144275016025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275016026 S-adenosylmethionine binding site [chemical binding]; other site 1144275016027 Flagellin N-methylase; Region: FliB; cl00497 1144275016028 Glycerate kinase family; Region: Gly_kinase; cl00841 1144275016029 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1144275016030 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1144275016031 active site 1144275016032 Protein of unknown function (DUF419); Region: DUF419; cl15265 1144275016033 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1144275016034 dimer interface [polypeptide binding]; other site 1144275016035 substrate binding site [chemical binding]; other site 1144275016036 metal binding sites [ion binding]; metal-binding site 1144275016037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275016038 putative acyl-acceptor binding pocket; other site 1144275016039 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1144275016040 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1144275016041 motif 1; other site 1144275016042 dimer interface [polypeptide binding]; other site 1144275016043 active site 1144275016044 motif 2; other site 1144275016045 motif 3; other site 1144275016046 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275016047 Zn binding site [ion binding]; other site 1144275016048 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275016049 phosphopeptide binding site; other site 1144275016050 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1144275016051 Short C-terminal domain; Region: SHOCT; cl01373 1144275016052 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275016053 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1144275016054 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275016055 Walker A/P-loop; other site 1144275016056 ATP binding site [chemical binding]; other site 1144275016057 Q-loop/lid; other site 1144275016058 ABC transporter signature motif; other site 1144275016059 Walker B; other site 1144275016060 D-loop; other site 1144275016061 H-loop/switch region; other site 1144275016062 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1144275016063 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275016064 Rhomboid family; Region: Rhomboid; cl11446 1144275016065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016066 binding surface 1144275016067 TPR motif; other site 1144275016068 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275016069 phosphopeptide binding site; other site 1144275016070 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275016071 phosphopeptide binding site; other site 1144275016072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275016073 TPR motif; other site 1144275016074 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275016075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016076 active site 1144275016077 phosphorylation site [posttranslational modification] 1144275016078 intermolecular recognition site; other site 1144275016079 dimerization interface [polypeptide binding]; other site 1144275016080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1144275016081 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1144275016082 substrate binding site [chemical binding]; other site 1144275016083 oxyanion hole (OAH) forming residues; other site 1144275016084 trimer interface [polypeptide binding]; other site 1144275016085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1144275016086 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1144275016087 carboxyltransferase (CT) interaction site; other site 1144275016088 biotinylation site [posttranslational modification]; other site 1144275016089 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1144275016090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1144275016091 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275016092 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1144275016093 cell division protein FtsZ; Validated; Region: PRK09330 1144275016094 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1144275016095 nucleotide binding site [chemical binding]; other site 1144275016096 SulA interaction site; other site 1144275016097 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1144275016098 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275016099 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275016100 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275016101 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1144275016102 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275016103 ligand binding site [chemical binding]; other site 1144275016104 cell division protein FtsA; Region: ftsA; TIGR01174 1144275016105 Cell division protein FtsA; Region: FtsA; cl11496 1144275016106 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1144275016107 ATP binding site [chemical binding]; other site 1144275016108 profilin binding site; other site 1144275016109 gelsolin binding site; other site 1144275016110 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1144275016111 Cell division protein FtsQ; Region: FtsQ; pfam03799 1144275016112 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1144275016113 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1144275016114 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275016115 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652 1144275016116 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275016117 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1144275016118 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1144275016119 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1144275016120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1144275016121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1144275016122 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1144275016123 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1144275016124 active site 1144275016125 homodimer interface [polypeptide binding]; other site 1144275016126 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1144275016127 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 1144275016128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275016129 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1144275016130 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1144275016131 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1144275016132 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1144275016133 Mg++ binding site [ion binding]; other site 1144275016134 putative catalytic motif [active] 1144275016135 putative substrate binding site [chemical binding]; other site 1144275016136 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1144275016137 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1144275016138 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1144275016139 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1144275016140 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1144275016141 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1144275016142 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1144275016143 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1144275016144 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1144275016145 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1144275016146 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275016147 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1144275016148 Septum formation initiator; Region: DivIC; cl11433 1144275016149 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1144275016150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275016151 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1144275016152 anti sigma factor interaction site; other site 1144275016153 regulatory phosphorylation site [posttranslational modification]; other site 1144275016154 cell division protein MraZ; Reviewed; Region: PRK00326 1144275016155 MraZ protein; Region: MraZ; pfam02381 1144275016156 MraZ protein; Region: MraZ; pfam02381 1144275016157 PilZ domain; Region: PilZ; cl01260 1144275016158 PilZ domain; Region: PilZ; cl01260 1144275016159 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275016160 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275016161 active site 1144275016162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275016163 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275016164 active site 1144275016165 ATP binding site [chemical binding]; other site 1144275016166 substrate binding site [chemical binding]; other site 1144275016167 activation loop (A-loop); other site 1144275016168 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016169 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1144275016170 Peptidase family M54; Region: Peptidase_M54; cl00835 1144275016171 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275016172 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1144275016173 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1144275016174 putative active site [active] 1144275016175 metal binding site [ion binding]; metal-binding site 1144275016176 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1144275016177 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1144275016178 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1144275016179 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275016180 NAD(P) binding site [chemical binding]; other site 1144275016181 catalytic residues [active] 1144275016182 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1144275016183 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1144275016184 catalytic triad [active] 1144275016185 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1144275016186 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275016187 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1144275016188 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1144275016189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275016190 PAS domain; Region: PAS_9; pfam13426 1144275016191 hypothetical protein; Validated; Region: PRK09039 1144275016192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016193 dimer interface [polypeptide binding]; other site 1144275016194 phosphorylation site [posttranslational modification] 1144275016195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016196 ATP binding site [chemical binding]; other site 1144275016197 Mg2+ binding site [ion binding]; other site 1144275016198 G-X-G motif; other site 1144275016199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016200 active site 1144275016201 phosphorylation site [posttranslational modification] 1144275016202 intermolecular recognition site; other site 1144275016203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275016204 dimerization interface [polypeptide binding]; other site 1144275016205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016206 dimer interface [polypeptide binding]; other site 1144275016207 phosphorylation site [posttranslational modification] 1144275016208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016209 ATP binding site [chemical binding]; other site 1144275016210 Mg2+ binding site [ion binding]; other site 1144275016211 G-X-G motif; other site 1144275016212 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1144275016213 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1144275016214 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1144275016215 RNA binding site [nucleotide binding]; other site 1144275016216 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1144275016217 multimer interface [polypeptide binding]; other site 1144275016218 Walker A motif; other site 1144275016219 ATP binding site [chemical binding]; other site 1144275016220 Walker B motif; other site 1144275016221 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1144275016222 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1144275016223 nucleotide binding pocket [chemical binding]; other site 1144275016224 K-X-D-G motif; other site 1144275016225 catalytic site [active] 1144275016226 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1144275016227 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1144275016228 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1144275016229 Dimer interface [polypeptide binding]; other site 1144275016230 BRCT sequence motif; other site 1144275016231 Acylphosphatase; Region: Acylphosphatase; cl00551 1144275016232 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1144275016233 homodimer interface [polypeptide binding]; other site 1144275016234 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1144275016235 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1144275016236 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275016237 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1144275016238 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1144275016239 IHF dimer interface [polypeptide binding]; other site 1144275016240 IHF - DNA interface [nucleotide binding]; other site 1144275016241 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1144275016242 FHIPEP family; Region: FHIPEP; pfam00771 1144275016243 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1144275016244 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1144275016245 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1144275016246 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1144275016247 FliP family; Region: FliP; cl00593 1144275016248 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1144275016249 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1144275016250 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1144275016251 PilZ domain; Region: PilZ; cl01260 1144275016252 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275016253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016254 active site 1144275016255 phosphorylation site [posttranslational modification] 1144275016256 intermolecular recognition site; other site 1144275016257 dimerization interface [polypeptide binding]; other site 1144275016258 TPR repeat; Region: TPR_11; pfam13414 1144275016259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275016260 binding surface 1144275016261 TPR motif; other site 1144275016262 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1144275016263 Oxygen tolerance; Region: BatD; pfam13584 1144275016264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016265 binding surface 1144275016266 TPR motif; other site 1144275016267 TPR repeat; Region: TPR_11; pfam13414 1144275016268 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275016269 metal ion-dependent adhesion site (MIDAS); other site 1144275016270 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1144275016271 metal ion-dependent adhesion site (MIDAS); other site 1144275016272 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1144275016273 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275016274 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275016275 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275016276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016277 Walker A motif; other site 1144275016278 ATP binding site [chemical binding]; other site 1144275016279 Walker B motif; other site 1144275016280 arginine finger; other site 1144275016281 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275016282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275016283 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1144275016284 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 1144275016285 GDYXXLXY protein; Region: GDYXXLXY; cl02066 1144275016286 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275016287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016288 Walker A motif; other site 1144275016289 ATP binding site [chemical binding]; other site 1144275016290 Walker B motif; other site 1144275016291 arginine finger; other site 1144275016292 Predicted membrane protein [Function unknown]; Region: COG2860 1144275016293 UPF0126 domain; Region: UPF0126; pfam03458 1144275016294 UPF0126 domain; Region: UPF0126; pfam03458 1144275016295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275016296 S-adenosylmethionine binding site [chemical binding]; other site 1144275016297 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1144275016298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1144275016299 TolB amino-terminal domain; Region: TolB_N; cl00639 1144275016300 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1144275016301 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1144275016302 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275016303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016304 active site 1144275016305 phosphorylation site [posttranslational modification] 1144275016306 intermolecular recognition site; other site 1144275016307 dimerization interface [polypeptide binding]; other site 1144275016308 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1144275016309 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275016310 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275016311 catalytic residue [active] 1144275016312 autolysin; Reviewed; Region: PRK06347 1144275016313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275016314 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275016315 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 1144275016316 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275016317 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1144275016318 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1144275016319 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1144275016320 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016321 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275016322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275016323 active site 1144275016324 ATP binding site [chemical binding]; other site 1144275016325 substrate binding site [chemical binding]; other site 1144275016326 activation loop (A-loop); other site 1144275016327 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016328 FtsX-like permease family; Region: FtsX; cl15850 1144275016329 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275016330 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275016331 Walker A/P-loop; other site 1144275016332 ATP binding site [chemical binding]; other site 1144275016333 Q-loop/lid; other site 1144275016334 ABC transporter signature motif; other site 1144275016335 Walker B; other site 1144275016336 D-loop; other site 1144275016337 H-loop/switch region; other site 1144275016338 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1144275016339 NMT1-like family; Region: NMT1_2; cl15260 1144275016340 PspA/IM30 family; Region: PspA_IM30; pfam04012 1144275016341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016342 dimer interface [polypeptide binding]; other site 1144275016343 phosphorylation site [posttranslational modification] 1144275016344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016345 ATP binding site [chemical binding]; other site 1144275016346 Mg2+ binding site [ion binding]; other site 1144275016347 G-X-G motif; other site 1144275016348 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1144275016349 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1144275016350 active site 1144275016351 putative substrate binding pocket [chemical binding]; other site 1144275016352 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1144275016353 active site 1144275016354 catalytic motif [active] 1144275016355 Zn binding site [ion binding]; other site 1144275016356 PilZ domain; Region: PilZ; cl01260 1144275016357 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 1144275016358 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1144275016359 active site residue [active] 1144275016360 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1144275016361 ATP binding site [chemical binding]; other site 1144275016362 substrate interface [chemical binding]; other site 1144275016363 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1144275016364 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1144275016365 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1144275016366 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1144275016367 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1144275016368 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1144275016369 ligand binding site [chemical binding]; other site 1144275016370 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1144275016371 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1144275016372 Walker A/P-loop; other site 1144275016373 ATP binding site [chemical binding]; other site 1144275016374 Q-loop/lid; other site 1144275016375 ABC transporter signature motif; other site 1144275016376 Walker B; other site 1144275016377 D-loop; other site 1144275016378 H-loop/switch region; other site 1144275016379 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1144275016380 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1144275016381 TM-ABC transporter signature motif; other site 1144275016382 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1144275016383 TM-ABC transporter signature motif; other site 1144275016384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016385 active site 1144275016386 phosphorylation site [posttranslational modification] 1144275016387 intermolecular recognition site; other site 1144275016388 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1144275016389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016390 ATP binding site [chemical binding]; other site 1144275016391 Mg2+ binding site [ion binding]; other site 1144275016392 G-X-G motif; other site 1144275016393 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1144275016394 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1144275016395 active site 1144275016396 substrate binding site [chemical binding]; other site 1144275016397 metal binding site [ion binding]; metal-binding site 1144275016398 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1144275016399 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1144275016400 intersubunit interface [polypeptide binding]; other site 1144275016401 active site 1144275016402 catalytic residue [active] 1144275016403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275016404 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275016405 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1144275016406 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1144275016407 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1144275016408 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1144275016409 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1144275016410 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016411 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1144275016412 Putative zinc ribbon domain; Region: DUF164; pfam02591 1144275016413 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1144275016414 RNA/DNA hybrid binding site [nucleotide binding]; other site 1144275016415 active site 1144275016416 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1144275016417 RNA/DNA hybrid binding site [nucleotide binding]; other site 1144275016418 active site 1144275016419 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275016420 phosphopeptide binding site; other site 1144275016421 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1144275016422 substrate binding pocket [chemical binding]; other site 1144275016423 chain length determination region; other site 1144275016424 substrate-Mg2+ binding site; other site 1144275016425 catalytic residues [active] 1144275016426 aspartate-rich region 1; other site 1144275016427 active site lid residues [active] 1144275016428 aspartate-rich region 2; other site 1144275016429 putative oxidoreductase; Provisional; Region: PRK13984 1144275016430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275016431 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1144275016432 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275016433 active site 1144275016434 ATP binding site [chemical binding]; other site 1144275016435 substrate binding site [chemical binding]; other site 1144275016436 activation loop (A-loop); other site 1144275016437 Predicted ATPase [General function prediction only]; Region: COG3899 1144275016438 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016439 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275016440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275016441 S-adenosylmethionine binding site [chemical binding]; other site 1144275016442 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1144275016443 HSP70 interaction site [polypeptide binding]; other site 1144275016444 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1144275016445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016446 TPR motif; other site 1144275016447 binding surface 1144275016448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016449 binding surface 1144275016450 TPR motif; other site 1144275016451 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1144275016452 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275016453 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275016454 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1144275016455 Uncharacterized conserved protein [Function unknown]; Region: COG4021 1144275016456 Thg1 C terminal domain; Region: Thg1C; pfam14413 1144275016457 AAA domain; Region: AAA_33; pfam13671 1144275016458 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1144275016459 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1144275016460 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1144275016461 GTP binding site [chemical binding]; other site 1144275016462 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275016463 Zn binding site [ion binding]; other site 1144275016464 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016465 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016466 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 1144275016467 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1144275016468 DXD motif; other site 1144275016469 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1144275016470 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1144275016471 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275016472 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016473 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1144275016474 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1144275016475 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1144275016476 protein binding site [polypeptide binding]; other site 1144275016477 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1144275016478 Catalytic dyad [active] 1144275016479 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275016480 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275016481 FtsX-like permease family; Region: FtsX; cl15850 1144275016482 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1144275016483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016484 Walker A/P-loop; other site 1144275016485 ATP binding site [chemical binding]; other site 1144275016486 Q-loop/lid; other site 1144275016487 ABC transporter signature motif; other site 1144275016488 Walker B; other site 1144275016489 D-loop; other site 1144275016490 H-loop/switch region; other site 1144275016491 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 1144275016492 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1144275016493 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016494 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275016495 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275016496 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275016497 TolB amino-terminal domain; Region: TolB_N; cl00639 1144275016498 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275016499 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275016500 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275016501 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275016502 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275016503 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275016504 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1144275016505 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275016506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275016507 catalytic residue [active] 1144275016508 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1144275016509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275016510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275016511 putative substrate translocation pore; other site 1144275016512 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1144275016513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275016514 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1144275016515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275016516 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 1144275016517 putative acyl-acceptor binding pocket; other site 1144275016518 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1144275016519 active site 1144275016520 catalytic residues [active] 1144275016521 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275016522 Putative zinc-finger; Region: zf-HC2; cl15806 1144275016523 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275016524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275016525 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1144275016526 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275016527 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275016528 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275016529 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275016530 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275016531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1144275016532 Family of unknown function (DUF490); Region: DUF490; pfam04357 1144275016533 Family of unknown function (DUF490); Region: DUF490; pfam04357 1144275016534 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1144275016535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016536 Walker A motif; other site 1144275016537 ATP binding site [chemical binding]; other site 1144275016538 Walker B motif; other site 1144275016539 arginine finger; other site 1144275016540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016541 binding surface 1144275016542 TPR motif; other site 1144275016543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016544 TPR motif; other site 1144275016545 binding surface 1144275016546 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1144275016547 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1144275016548 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1144275016549 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275016550 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1144275016551 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1144275016552 carboxyltransferase (CT) interaction site; other site 1144275016553 biotinylation site [posttranslational modification]; other site 1144275016554 elongation factor P; Validated; Region: PRK00529 1144275016555 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1144275016556 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1144275016557 RNA binding site [nucleotide binding]; other site 1144275016558 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1144275016559 RNA binding site [nucleotide binding]; other site 1144275016560 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1144275016561 AMIN domain; Region: AMIN; pfam11741 1144275016562 AMIN domain; Region: AMIN; pfam11741 1144275016563 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1144275016564 Secretin and TonB N terminus short domain; Region: STN; cl06624 1144275016565 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1144275016566 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1144275016567 Pilus assembly protein, PilP; Region: PilP; pfam04351 1144275016568 Pilus assembly protein, PilO; Region: PilO; cl01234 1144275016569 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1144275016570 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1144275016571 Competence protein A; Region: Competence_A; pfam11104 1144275016572 Cell division protein FtsA; Region: FtsA; cl11496 1144275016573 Cell division protein FtsA; Region: FtsA; cl11496 1144275016574 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275016575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016576 active site 1144275016577 phosphorylation site [posttranslational modification] 1144275016578 intermolecular recognition site; other site 1144275016579 dimerization interface [polypeptide binding]; other site 1144275016580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016581 Walker A motif; other site 1144275016582 ATP binding site [chemical binding]; other site 1144275016583 Walker B motif; other site 1144275016584 arginine finger; other site 1144275016585 Helix-turn-helix domains; Region: HTH; cl00088 1144275016586 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1144275016587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016588 dimer interface [polypeptide binding]; other site 1144275016589 phosphorylation site [posttranslational modification] 1144275016590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016591 ATP binding site [chemical binding]; other site 1144275016592 G-X-G motif; other site 1144275016593 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1144275016594 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1144275016595 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1144275016596 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1144275016597 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1144275016598 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1144275016599 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1144275016600 Walker A/P-loop; other site 1144275016601 ATP binding site [chemical binding]; other site 1144275016602 Q-loop/lid; other site 1144275016603 ABC transporter signature motif; other site 1144275016604 Walker B; other site 1144275016605 D-loop; other site 1144275016606 H-loop/switch region; other site 1144275016607 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275016608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016609 active site 1144275016610 phosphorylation site [posttranslational modification] 1144275016611 intermolecular recognition site; other site 1144275016612 dimerization interface [polypeptide binding]; other site 1144275016613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016614 Walker A motif; other site 1144275016615 ATP binding site [chemical binding]; other site 1144275016616 Walker B motif; other site 1144275016617 arginine finger; other site 1144275016618 Helix-turn-helix domains; Region: HTH; cl00088 1144275016619 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275016620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016621 dimer interface [polypeptide binding]; other site 1144275016622 phosphorylation site [posttranslational modification] 1144275016623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016624 ATP binding site [chemical binding]; other site 1144275016625 Mg2+ binding site [ion binding]; other site 1144275016626 G-X-G motif; other site 1144275016627 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1144275016628 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1144275016629 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1144275016630 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1144275016631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016632 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1144275016633 Walker A motif; other site 1144275016634 ATP binding site [chemical binding]; other site 1144275016635 Walker B motif; other site 1144275016636 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1144275016637 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275016638 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1144275016639 Walker A motif; other site 1144275016640 ATP binding site [chemical binding]; other site 1144275016641 Walker B motif; other site 1144275016642 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1144275016643 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1144275016644 active site 1144275016645 Riboflavin kinase; Region: Flavokinase; cl03312 1144275016646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275016647 S-adenosylmethionine binding site [chemical binding]; other site 1144275016648 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275016649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016650 active site 1144275016651 phosphorylation site [posttranslational modification] 1144275016652 intermolecular recognition site; other site 1144275016653 dimerization interface [polypeptide binding]; other site 1144275016654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275016655 metal binding site [ion binding]; metal-binding site 1144275016656 active site 1144275016657 I-site; other site 1144275016658 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1144275016659 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1144275016660 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1144275016661 active site 1144275016662 catalytic site [active] 1144275016663 substrate binding site [chemical binding]; other site 1144275016664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016666 HEAT repeats; Region: HEAT_2; pfam13646 1144275016667 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1144275016668 peptidase domain interface [polypeptide binding]; other site 1144275016669 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1144275016670 active site 1144275016671 catalytic triad [active] 1144275016672 calcium binding site [ion binding]; other site 1144275016673 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1144275016674 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1144275016675 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1144275016676 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275016677 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1144275016678 active site 1144275016679 CoA binding site [chemical binding]; other site 1144275016680 trimer interface [polypeptide binding]; other site 1144275016681 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275016682 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1144275016683 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1144275016684 motif 1; other site 1144275016685 active site 1144275016686 motif 2; other site 1144275016687 motif 3; other site 1144275016688 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1144275016689 DHHA1 domain; Region: DHHA1; pfam02272 1144275016690 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1144275016691 PilZ domain; Region: PilZ; cl01260 1144275016692 cell division protein ZipA; Provisional; Region: PRK03427 1144275016693 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 1144275016694 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1144275016695 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1144275016696 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 1144275016697 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1144275016698 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1144275016699 protein binding site [polypeptide binding]; other site 1144275016700 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1144275016701 Catalytic dyad [active] 1144275016702 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1144275016703 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1144275016704 active site 1144275016705 catalytic site [active] 1144275016706 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1144275016707 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1144275016708 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1144275016709 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1144275016710 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1144275016711 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275016712 P-loop; other site 1144275016713 Magnesium ion binding site [ion binding]; other site 1144275016714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275016715 Magnesium ion binding site [ion binding]; other site 1144275016716 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275016717 DTAP/Switch II; other site 1144275016718 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275016719 P loop; other site 1144275016720 Nucleotide binding site [chemical binding]; other site 1144275016721 DTAP/Switch II; other site 1144275016722 Switch I; other site 1144275016723 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275016724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016725 binding surface 1144275016726 TPR motif; other site 1144275016727 Peptidase family M48; Region: Peptidase_M48; cl12018 1144275016728 TPR repeat; Region: TPR_11; pfam13414 1144275016729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275016730 binding surface 1144275016731 TPR motif; other site 1144275016732 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1144275016733 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1144275016734 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275016735 PrkA AAA domain; Region: AAA_PrkA; smart00763 1144275016736 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1144275016737 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275016738 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1144275016739 SpoVR like protein; Region: SpoVR; pfam04293 1144275016740 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1144275016741 putative peptidase; Provisional; Region: PRK11649 1144275016742 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275016743 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1144275016744 homodimer interface [polypeptide binding]; other site 1144275016745 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1144275016746 active site pocket [active] 1144275016747 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1144275016748 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 1144275016749 active site 1144275016750 Zn binding site [ion binding]; other site 1144275016751 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275016752 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275016753 Lamin Tail Domain; Region: LTD; pfam00932 1144275016754 short chain dehydrogenase; Provisional; Region: PRK07576 1144275016755 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1144275016756 NAD(P) binding site [chemical binding]; other site 1144275016757 substrate binding site [chemical binding]; other site 1144275016758 homotetramer interface [polypeptide binding]; other site 1144275016759 active site 1144275016760 homodimer interface [polypeptide binding]; other site 1144275016761 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1144275016762 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1144275016763 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1144275016764 generic binding surface II; other site 1144275016765 generic binding surface I; other site 1144275016766 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1144275016767 Sulfatase; Region: Sulfatase; cl10460 1144275016768 CAAX protease self-immunity; Region: Abi; cl00558 1144275016769 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1144275016770 active site 1144275016771 Cupin domain; Region: Cupin_2; cl09118 1144275016772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275016773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275016774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275016775 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1144275016776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275016777 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1144275016778 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1144275016779 calcium binding site 2 [ion binding]; other site 1144275016780 active site 1144275016781 catalytic triad [active] 1144275016782 calcium binding site 1 [ion binding]; other site 1144275016783 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1144275016784 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1144275016785 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1144275016786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275016787 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1144275016788 dimer interface [polypeptide binding]; other site 1144275016789 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1144275016790 active site 1144275016791 Zn binding site [ion binding]; other site 1144275016792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275016793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1144275016794 active site 1144275016795 catalytic tetrad [active] 1144275016796 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1144275016797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1144275016798 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1144275016799 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1144275016800 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275016801 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1144275016802 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275016803 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1144275016804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275016805 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1144275016806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275016807 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1144275016808 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1144275016809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275016810 NAD(P) binding site [chemical binding]; other site 1144275016811 active site 1144275016812 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1144275016813 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275016814 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1144275016815 homodimer interface [polypeptide binding]; other site 1144275016816 homotetramer interface [polypeptide binding]; other site 1144275016817 active site pocket [active] 1144275016818 cleavage site 1144275016819 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275016820 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1144275016821 PAS domain S-box; Region: sensory_box; TIGR00229 1144275016822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275016823 putative active site [active] 1144275016824 heme pocket [chemical binding]; other site 1144275016825 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275016826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275016827 putative active site [active] 1144275016828 heme pocket [chemical binding]; other site 1144275016829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016830 dimer interface [polypeptide binding]; other site 1144275016831 phosphorylation site [posttranslational modification] 1144275016832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016833 ATP binding site [chemical binding]; other site 1144275016834 Mg2+ binding site [ion binding]; other site 1144275016835 G-X-G motif; other site 1144275016836 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275016837 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1144275016838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016839 Walker A motif; other site 1144275016840 ATP binding site [chemical binding]; other site 1144275016841 Walker B motif; other site 1144275016842 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1144275016843 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275016844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275016845 dimer interface [polypeptide binding]; other site 1144275016846 phosphorylation site [posttranslational modification] 1144275016847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275016848 ATP binding site [chemical binding]; other site 1144275016849 Mg2+ binding site [ion binding]; other site 1144275016850 G-X-G motif; other site 1144275016851 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275016852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016853 active site 1144275016854 phosphorylation site [posttranslational modification] 1144275016855 intermolecular recognition site; other site 1144275016856 dimerization interface [polypeptide binding]; other site 1144275016857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016858 Walker A motif; other site 1144275016859 ATP binding site [chemical binding]; other site 1144275016860 Walker B motif; other site 1144275016861 arginine finger; other site 1144275016862 Phosphate-selective porin O and P; Region: Porin_O_P; cl01524 1144275016863 acetyl-CoA synthetase; Provisional; Region: PRK00174 1144275016864 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1144275016865 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275016866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275016867 Protein of unknown function, DUF485; Region: DUF485; cl01231 1144275016868 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1144275016869 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1144275016870 Na binding site [ion binding]; other site 1144275016871 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1144275016872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275016873 Ion transport protein; Region: Ion_trans; pfam00520 1144275016874 Ion channel; Region: Ion_trans_2; cl11596 1144275016875 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1144275016876 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1144275016877 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1144275016878 E-class dimer interface [polypeptide binding]; other site 1144275016879 P-class dimer interface [polypeptide binding]; other site 1144275016880 active site 1144275016881 Cu2+ binding site [ion binding]; other site 1144275016882 Zn2+ binding site [ion binding]; other site 1144275016883 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275016884 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1144275016885 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 1144275016886 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1144275016887 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 1144275016888 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 1144275016889 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 1144275016890 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275016891 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275016892 active site 1144275016893 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1144275016894 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1144275016895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275016896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275016897 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1144275016898 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1144275016899 ATP binding site [chemical binding]; other site 1144275016900 Mg++ binding site [ion binding]; other site 1144275016901 motif III; other site 1144275016902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275016903 nucleotide binding region [chemical binding]; other site 1144275016904 ATP-binding site [chemical binding]; other site 1144275016905 DbpA RNA binding domain; Region: DbpA; pfam03880 1144275016906 DbpA RNA binding domain; Region: DbpA; pfam03880 1144275016907 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 1144275016908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275016909 sequence-specific DNA binding site [nucleotide binding]; other site 1144275016910 salt bridge; other site 1144275016911 glutamate dehydrogenase; Region: PLN02477 1144275016912 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1144275016913 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1144275016914 NAD(P) binding site [chemical binding]; other site 1144275016915 threonine dehydratase; Provisional; Region: PRK08198 1144275016916 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1144275016917 tetramer interface [polypeptide binding]; other site 1144275016918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275016919 catalytic residue [active] 1144275016920 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1144275016921 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275016922 ribonuclease E; Reviewed; Region: rne; PRK10811 1144275016923 YceI-like domain; Region: YceI; cl01001 1144275016924 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1144275016925 putative active site [active] 1144275016926 metal binding site [ion binding]; metal-binding site 1144275016927 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1144275016928 Heme NO binding; Region: HNOB; cl15268 1144275016929 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275016930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275016931 Walker A motif; other site 1144275016932 ATP binding site [chemical binding]; other site 1144275016933 Walker B motif; other site 1144275016934 arginine finger; other site 1144275016935 Helix-turn-helix domains; Region: HTH; cl00088 1144275016936 putative acyltransferase; Provisional; Region: PRK05790 1144275016937 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1144275016938 dimer interface [polypeptide binding]; other site 1144275016939 active site 1144275016940 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1144275016941 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1144275016942 putative catalytic residue [active] 1144275016943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275016944 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275016945 active site 1144275016946 ATP binding site [chemical binding]; other site 1144275016947 substrate binding site [chemical binding]; other site 1144275016948 activation loop (A-loop); other site 1144275016949 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275016950 Predicted ATPase [General function prediction only]; Region: COG3899 1144275016951 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275016952 active site 1144275016953 substrate binding sites [chemical binding]; other site 1144275016954 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275016955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275016956 active site 1144275016957 phosphorylation site [posttranslational modification] 1144275016958 intermolecular recognition site; other site 1144275016959 dimerization interface [polypeptide binding]; other site 1144275016960 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1144275016961 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275016962 Glutamate binding site [chemical binding]; other site 1144275016963 NAD binding site [chemical binding]; other site 1144275016964 catalytic residues [active] 1144275016965 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1144275016966 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1144275016967 active site 1144275016968 catalytic residues [active] 1144275016969 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1144275016970 Cytochrome P450; Region: p450; pfam00067 1144275016971 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275016972 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1144275016973 putative C-terminal domain interface [polypeptide binding]; other site 1144275016974 putative GSH binding site (G-site) [chemical binding]; other site 1144275016975 putative dimer interface [polypeptide binding]; other site 1144275016976 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275016977 N-terminal domain interface [polypeptide binding]; other site 1144275016978 dimer interface [polypeptide binding]; other site 1144275016979 substrate binding pocket (H-site) [chemical binding]; other site 1144275016980 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275016981 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275016982 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1144275016983 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1144275016984 homodimer interface [polypeptide binding]; other site 1144275016985 substrate-cofactor binding pocket; other site 1144275016986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275016987 catalytic residue [active] 1144275016988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275016989 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1144275016990 nucleotide binding site [chemical binding]; other site 1144275016991 aspartate kinase; Provisional; Region: PRK07431 1144275016992 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1144275016993 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 1144275016994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275016995 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1144275016996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275016997 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275016998 catalytic residue [active] 1144275016999 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275017000 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1144275017001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017002 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275017003 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1144275017004 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1144275017005 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1144275017006 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1144275017007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275017008 putative substrate translocation pore; other site 1144275017009 potential frameshift: common BLAST hit: gi|338532994|ref|YP_004666328.1| methyl-accepting protein RppA 1144275017010 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1144275017011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275017012 dimerization interface [polypeptide binding]; other site 1144275017013 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275017014 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275017015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275017016 dimer interface [polypeptide binding]; other site 1144275017017 putative CheW interface [polypeptide binding]; other site 1144275017018 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1144275017019 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1144275017020 Scramblase; Region: Scramblase; cl02043 1144275017021 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1144275017022 putative C-terminal domain interface [polypeptide binding]; other site 1144275017023 putative GSH binding site (G-site) [chemical binding]; other site 1144275017024 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275017025 putative dimer interface [polypeptide binding]; other site 1144275017026 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1144275017027 dimer interface [polypeptide binding]; other site 1144275017028 N-terminal domain interface [polypeptide binding]; other site 1144275017029 putative substrate binding pocket (H-site) [chemical binding]; other site 1144275017030 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1144275017031 Sulfate transporter family; Region: Sulfate_transp; cl15842 1144275017032 Sulfate transporter family; Region: Sulfate_transp; cl15842 1144275017033 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1144275017034 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1144275017035 Sulfatase; Region: Sulfatase; cl10460 1144275017036 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1144275017037 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275017038 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1144275017039 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1144275017040 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 1144275017041 Sulfate transporter family; Region: Sulfate_transp; cl15842 1144275017042 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1144275017043 Sulfate transporter family; Region: Sulfate_transp; cl15842 1144275017044 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1144275017045 Membrane transport protein; Region: Mem_trans; cl09117 1144275017046 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1144275017047 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275017048 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1144275017049 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1144275017050 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1144275017051 Sulfatase; Region: Sulfatase; cl10460 1144275017052 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1144275017053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017054 active site 1144275017055 phosphorylation site [posttranslational modification] 1144275017056 intermolecular recognition site; other site 1144275017057 dimerization interface [polypeptide binding]; other site 1144275017058 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1144275017059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017060 NAD(P) binding site [chemical binding]; other site 1144275017061 active site 1144275017062 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1144275017063 active site 1144275017064 dimer interface [polypeptide binding]; other site 1144275017065 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1144275017066 Transglycosylase; Region: Transgly; cl07896 1144275017067 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275017068 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1144275017069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1144275017070 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1144275017071 active site 1144275017072 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1144275017073 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1144275017074 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 1144275017075 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 1144275017076 MOSC domain; Region: MOSC; pfam03473 1144275017077 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1144275017078 EamA-like transporter family; Region: EamA; cl01037 1144275017079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275017080 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275017081 Cytochrome oxidase complex assembly protein 1; Region: Coa1; cl14904 1144275017082 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1144275017083 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1144275017084 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1144275017085 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1144275017086 Ligand binding site [chemical binding]; other site 1144275017087 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1144275017088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275017089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275017090 active site 1144275017091 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1144275017092 active site 1144275017093 intersubunit interactions; other site 1144275017094 catalytic residue [active] 1144275017095 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1144275017096 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1144275017097 putative active site [active] 1144275017098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1144275017099 Outer membrane lipoprotein; Region: YfiO; pfam13525 1144275017100 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1144275017101 catalytic center binding site [active] 1144275017102 ATP binding site [chemical binding]; other site 1144275017103 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1144275017104 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1144275017105 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1144275017106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017107 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1144275017108 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1144275017109 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1144275017110 dimer interface [polypeptide binding]; other site 1144275017111 active site 1144275017112 catalytic residue [active] 1144275017113 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1144275017114 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1144275017115 active site 1144275017116 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275017117 substrate binding site [chemical binding]; other site 1144275017118 catalytic residues [active] 1144275017119 dimer interface [polypeptide binding]; other site 1144275017120 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1144275017121 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1144275017122 DNA binding site [nucleotide binding] 1144275017123 catalytic residue [active] 1144275017124 H2TH interface [polypeptide binding]; other site 1144275017125 putative catalytic residues [active] 1144275017126 turnover-facilitating residue; other site 1144275017127 intercalation triad [nucleotide binding]; other site 1144275017128 8OG recognition residue [nucleotide binding]; other site 1144275017129 putative reading head residues; other site 1144275017130 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1144275017131 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1144275017132 Peptidase family M48; Region: Peptidase_M48; cl12018 1144275017133 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1144275017134 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275017135 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1144275017136 EamA-like transporter family; Region: EamA; cl01037 1144275017137 EamA-like transporter family; Region: EamA; cl01037 1144275017138 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1144275017139 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1144275017140 4Fe-4S binding domain; Region: Fer4; cl02805 1144275017141 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1144275017142 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1144275017143 dimerization interface [polypeptide binding]; other site 1144275017144 active site 1144275017145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1144275017146 folate binding site [chemical binding]; other site 1144275017147 NADP+ binding site [chemical binding]; other site 1144275017148 Cytochrome c; Region: Cytochrom_C; cl11414 1144275017149 Iron permease FTR1 family; Region: FTR1; cl00475 1144275017150 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1144275017151 putative C-terminal domain interface [polypeptide binding]; other site 1144275017152 putative GSH binding site (G-site) [chemical binding]; other site 1144275017153 putative dimer interface [polypeptide binding]; other site 1144275017154 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275017155 N-terminal domain interface [polypeptide binding]; other site 1144275017156 dimer interface [polypeptide binding]; other site 1144275017157 substrate binding pocket (H-site) [chemical binding]; other site 1144275017158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275017159 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1144275017160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275017161 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1144275017162 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275017163 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1144275017164 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1144275017165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275017166 Coenzyme A binding pocket [chemical binding]; other site 1144275017167 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1144275017168 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1144275017169 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1144275017170 catalytic residues [active] 1144275017171 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275017172 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1144275017173 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1144275017174 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1144275017175 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1144275017176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017177 NAD(P) binding site [chemical binding]; other site 1144275017178 active site 1144275017179 Phospholipid methyltransferase; Region: PEMT; cl00763 1144275017180 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275017181 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1144275017182 putative active site [active] 1144275017183 putative dimer interface [polypeptide binding]; other site 1144275017184 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1144275017185 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1144275017186 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1144275017187 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 1144275017188 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1144275017189 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 1144275017190 HYR domain; Region: HYR; pfam02494 1144275017191 HYR domain; Region: HYR; pfam02494 1144275017192 HYR domain; Region: HYR; pfam02494 1144275017193 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1144275017194 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1144275017195 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275017196 active site 1144275017197 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1144275017198 catalytic residue [active] 1144275017199 DNA helicase, putative; Region: TIGR00376 1144275017200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275017201 Family description; Region: UvrD_C_2; cl15862 1144275017202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275017203 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275017204 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275017205 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275017206 active site 1144275017207 ATP binding site [chemical binding]; other site 1144275017208 substrate binding site [chemical binding]; other site 1144275017209 activation loop (A-loop); other site 1144275017210 transcriptional regulator ICP4; Provisional; Region: PHA03307 1144275017211 NMT1-like family; Region: NMT1_2; cl15260 1144275017212 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1144275017213 tellurite resistance protein terB; Region: terB; cd07176 1144275017214 putative metal binding site [ion binding]; other site 1144275017215 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1144275017216 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1144275017217 Ligand Binding Site [chemical binding]; other site 1144275017218 TIGR00269 family protein; Region: TIGR00269 1144275017219 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1144275017220 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1144275017221 catalytic site [active] 1144275017222 putative active site [active] 1144275017223 putative substrate binding site [chemical binding]; other site 1144275017224 HRDC domain; Region: HRDC; cl02578 1144275017225 HRDC domain; Region: HRDC; cl02578 1144275017226 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1144275017227 dimerization interface [polypeptide binding]; other site 1144275017228 potential frameshift: common BLAST hit: gi|338532916|ref|YP_004666250.1| thermostable carboxypeptidase 1 1144275017229 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1144275017230 active site 1144275017231 Zn binding site [ion binding]; other site 1144275017232 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275017233 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1144275017234 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1144275017235 G1 box; other site 1144275017236 putative GEF interaction site [polypeptide binding]; other site 1144275017237 GTP/Mg2+ binding site [chemical binding]; other site 1144275017238 Switch I region; other site 1144275017239 G2 box; other site 1144275017240 G3 box; other site 1144275017241 Switch II region; other site 1144275017242 G4 box; other site 1144275017243 G5 box; other site 1144275017244 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1144275017245 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1144275017246 homotrimer interaction site [polypeptide binding]; other site 1144275017247 putative active site [active] 1144275017248 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1144275017249 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017250 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017251 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017252 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017253 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017254 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017255 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275017256 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275017257 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1144275017258 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1144275017259 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1144275017260 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1144275017261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275017262 Walker A/P-loop; other site 1144275017263 ATP binding site [chemical binding]; other site 1144275017264 Q-loop/lid; other site 1144275017265 ABC transporter signature motif; other site 1144275017266 Walker B; other site 1144275017267 D-loop; other site 1144275017268 H-loop/switch region; other site 1144275017269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275017270 S-adenosylmethionine binding site [chemical binding]; other site 1144275017271 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1144275017272 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275017273 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1144275017274 hypothetical protein; Provisional; Region: PRK07907 1144275017275 active site 1144275017276 metal binding site [ion binding]; metal-binding site 1144275017277 dimer interface [polypeptide binding]; other site 1144275017278 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275017279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017280 active site 1144275017281 phosphorylation site [posttranslational modification] 1144275017282 intermolecular recognition site; other site 1144275017283 dimerization interface [polypeptide binding]; other site 1144275017284 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1144275017285 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 1144275017286 PilZ domain; Region: PilZ; cl01260 1144275017287 PAS fold; Region: PAS; pfam00989 1144275017288 GAF domain; Region: GAF_2; pfam13185 1144275017289 GAF domain; Region: GAF; cl15785 1144275017290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275017291 dimer interface [polypeptide binding]; other site 1144275017292 phosphorylation site [posttranslational modification] 1144275017293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275017294 ATP binding site [chemical binding]; other site 1144275017295 Mg2+ binding site [ion binding]; other site 1144275017296 G-X-G motif; other site 1144275017297 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1144275017298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275017299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275017300 PAS fold; Region: PAS_4; pfam08448 1144275017301 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275017302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275017303 dimer interface [polypeptide binding]; other site 1144275017304 phosphorylation site [posttranslational modification] 1144275017305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275017306 ATP binding site [chemical binding]; other site 1144275017307 Mg2+ binding site [ion binding]; other site 1144275017308 G-X-G motif; other site 1144275017309 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275017310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017311 active site 1144275017312 phosphorylation site [posttranslational modification] 1144275017313 intermolecular recognition site; other site 1144275017314 dimerization interface [polypeptide binding]; other site 1144275017315 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275017316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017317 active site 1144275017318 phosphorylation site [posttranslational modification] 1144275017319 intermolecular recognition site; other site 1144275017320 dimerization interface [polypeptide binding]; other site 1144275017321 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1144275017322 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275017323 putative di-iron ligands [ion binding]; other site 1144275017324 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275017325 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1144275017326 Interdomain contacts; other site 1144275017327 Cytokine receptor motif; other site 1144275017328 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1144275017329 Glyco_18 domain; Region: Glyco_18; smart00636 1144275017330 active site 1144275017331 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1144275017332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1144275017333 putative acyl-acceptor binding pocket; other site 1144275017334 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1144275017335 FAD binding pocket [chemical binding]; other site 1144275017336 conserved FAD binding motif [chemical binding]; other site 1144275017337 phosphate binding motif [ion binding]; other site 1144275017338 beta-alpha-beta structure motif; other site 1144275017339 NAD binding pocket [chemical binding]; other site 1144275017340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275017341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275017342 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1144275017343 NifU-like domain; Region: NifU; cl00484 1144275017344 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275017345 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1144275017346 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1144275017347 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1144275017348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275017349 Walker A motif; other site 1144275017350 ATP binding site [chemical binding]; other site 1144275017351 Walker B motif; other site 1144275017352 arginine finger; other site 1144275017353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275017354 Walker A motif; other site 1144275017355 ATP binding site [chemical binding]; other site 1144275017356 Walker B motif; other site 1144275017357 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1144275017358 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1144275017359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275017360 dimerization interface [polypeptide binding]; other site 1144275017361 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275017362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275017363 dimer interface [polypeptide binding]; other site 1144275017364 putative CheW interface [polypeptide binding]; other site 1144275017365 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1144275017366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017367 active site 1144275017368 phosphorylation site [posttranslational modification] 1144275017369 intermolecular recognition site; other site 1144275017370 dimerization interface [polypeptide binding]; other site 1144275017371 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275017372 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275017373 putative binding surface; other site 1144275017374 active site 1144275017375 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1144275017376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275017377 ATP binding site [chemical binding]; other site 1144275017378 Mg2+ binding site [ion binding]; other site 1144275017379 G-X-G motif; other site 1144275017380 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275017381 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275017382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017383 active site 1144275017384 phosphorylation site [posttranslational modification] 1144275017385 intermolecular recognition site; other site 1144275017386 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275017387 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1144275017388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275017389 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275017390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017391 active site 1144275017392 phosphorylation site [posttranslational modification] 1144275017393 intermolecular recognition site; other site 1144275017394 dimerization interface [polypeptide binding]; other site 1144275017395 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275017396 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275017397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017398 active site 1144275017399 phosphorylation site [posttranslational modification] 1144275017400 intermolecular recognition site; other site 1144275017401 dimerization interface [polypeptide binding]; other site 1144275017402 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1144275017403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017404 NAD(P) binding site [chemical binding]; other site 1144275017405 active site 1144275017406 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1144275017407 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1144275017408 TPP-binding site [chemical binding]; other site 1144275017409 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1144275017410 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1144275017411 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1144275017412 E3 interaction surface; other site 1144275017413 lipoyl attachment site [posttranslational modification]; other site 1144275017414 e3 binding domain; Region: E3_binding; pfam02817 1144275017415 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1144275017416 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1144275017417 DNA-binding site [nucleotide binding]; DNA binding site 1144275017418 RNA-binding motif; other site 1144275017419 translocation protein TolB; Provisional; Region: tolB; PRK05137 1144275017420 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1144275017421 Dienelactone hydrolase family; Region: DLH; pfam01738 1144275017422 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275017423 translocation protein TolB; Provisional; Region: tolB; PRK05137 1144275017424 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1144275017425 Dienelactone hydrolase family; Region: DLH; pfam01738 1144275017426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275017427 UPF0489 domain; Region: UPF0489; pfam12640 1144275017428 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1144275017429 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275017430 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275017431 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1144275017432 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1144275017433 cobalamin binding residues [chemical binding]; other site 1144275017434 putative BtuC binding residues; other site 1144275017435 dimer interface [polypeptide binding]; other site 1144275017436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275017437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275017438 active site 1144275017439 ATP binding site [chemical binding]; other site 1144275017440 substrate binding site [chemical binding]; other site 1144275017441 activation loop (A-loop); other site 1144275017442 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275017443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275017444 TPR repeat; Region: TPR_11; pfam13414 1144275017445 binding surface 1144275017446 TPR motif; other site 1144275017447 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1144275017448 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275017449 N-terminal plug; other site 1144275017450 ligand-binding site [chemical binding]; other site 1144275017451 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275017452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017453 active site 1144275017454 phosphorylation site [posttranslational modification] 1144275017455 intermolecular recognition site; other site 1144275017456 dimerization interface [polypeptide binding]; other site 1144275017457 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1144275017458 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1144275017459 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1144275017460 Moco binding site; other site 1144275017461 metal coordination site [ion binding]; other site 1144275017462 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275017463 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1144275017464 putative di-iron ligands [ion binding]; other site 1144275017465 Nudix hydrolase homolog; Region: PLN02791 1144275017466 heat shock protein 90; Provisional; Region: PRK05218 1144275017467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275017468 ATP binding site [chemical binding]; other site 1144275017469 Mg2+ binding site [ion binding]; other site 1144275017470 G-X-G motif; other site 1144275017471 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 1144275017472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017473 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1144275017474 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 1144275017475 active site 1144275017476 catalytic triad [active] 1144275017477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017478 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1144275017479 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1144275017480 NeuB family; Region: NeuB; cl00496 1144275017481 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1144275017482 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1144275017483 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1144275017484 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1144275017485 active site 1144275017486 ribulose/triose binding site [chemical binding]; other site 1144275017487 phosphate binding site [ion binding]; other site 1144275017488 substrate (anthranilate) binding pocket [chemical binding]; other site 1144275017489 product (indole) binding pocket [chemical binding]; other site 1144275017490 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 1144275017491 active site 1144275017492 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1144275017493 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1144275017494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275017495 catalytic residue [active] 1144275017496 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1144275017497 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1144275017498 substrate binding site [chemical binding]; other site 1144275017499 active site 1144275017500 catalytic residues [active] 1144275017501 heterodimer interface [polypeptide binding]; other site 1144275017502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275017503 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275017504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1144275017505 catalytic core [active] 1144275017506 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1144275017507 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1144275017508 glutamine binding [chemical binding]; other site 1144275017509 catalytic triad [active] 1144275017510 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1144275017511 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1144275017512 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1144275017513 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1144275017514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275017515 ATP-dependent DNA ligase; Validated; Region: PRK09247 1144275017516 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1144275017517 active site 1144275017518 DNA binding site [nucleotide binding] 1144275017519 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1144275017520 DNA binding site [nucleotide binding] 1144275017521 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1144275017522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275017523 ATP binding site [chemical binding]; other site 1144275017524 putative Mg++ binding site [ion binding]; other site 1144275017525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275017526 nucleotide binding region [chemical binding]; other site 1144275017527 ATP-binding site [chemical binding]; other site 1144275017528 DEAD/H associated; Region: DEAD_assoc; pfam08494 1144275017529 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1144275017530 putative active site [active] 1144275017531 putative metal binding site [ion binding]; other site 1144275017532 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1144275017533 heme-binding residues [chemical binding]; other site 1144275017534 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275017535 molybdopterin cofactor binding site; other site 1144275017536 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1144275017537 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1144275017538 4Fe-4S binding domain; Region: Fer4; cl02805 1144275017539 Polysulphide reductase, NrfD; Region: NrfD; cl01295 1144275017540 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1144275017541 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1144275017542 Cytochrome c; Region: Cytochrom_C; cl11414 1144275017543 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1144275017544 Cu(I) binding site [ion binding]; other site 1144275017545 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1144275017546 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1144275017547 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1144275017548 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1144275017549 D-pathway; other site 1144275017550 Low-spin heme binding site [chemical binding]; other site 1144275017551 Putative water exit pathway; other site 1144275017552 Binuclear center (active site) [active] 1144275017553 K-pathway; other site 1144275017554 Putative proton exit pathway; other site 1144275017555 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1144275017556 Subunit I/III interface [polypeptide binding]; other site 1144275017557 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1144275017558 Protein of unknown function, DUF481; Region: DUF481; cl01213 1144275017559 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275017560 Flagellin N-methylase; Region: FliB; cl00497 1144275017561 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1144275017562 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275017563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275017564 active site 1144275017565 phosphorylation site [posttranslational modification] 1144275017566 intermolecular recognition site; other site 1144275017567 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1144275017568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275017569 ATP binding site [chemical binding]; other site 1144275017570 putative Mg++ binding site [ion binding]; other site 1144275017571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275017572 nucleotide binding region [chemical binding]; other site 1144275017573 ATP-binding site [chemical binding]; other site 1144275017574 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1144275017575 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1144275017576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275017577 non-specific DNA binding site [nucleotide binding]; other site 1144275017578 salt bridge; other site 1144275017579 sequence-specific DNA binding site [nucleotide binding]; other site 1144275017580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1144275017581 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1144275017582 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275017583 active site 1144275017584 metal binding site [ion binding]; metal-binding site 1144275017585 Predicted membrane protein [Function unknown]; Region: COG2311 1144275017586 Protein of unknown function (DUF418); Region: DUF418; cl12135 1144275017587 Predicted membrane protein [Function unknown]; Region: COG2311 1144275017588 Protein of unknown function (DUF418); Region: DUF418; cl12135 1144275017589 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275017590 active site 1144275017591 Zn binding site [ion binding]; other site 1144275017592 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275017593 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275017594 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1144275017595 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1144275017596 NAD(P) binding site [chemical binding]; other site 1144275017597 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1144275017598 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275017599 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1144275017600 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1144275017601 thioester reductase domain; Region: Thioester-redct; TIGR01746 1144275017602 putative NAD(P) binding site [chemical binding]; other site 1144275017603 active site 1144275017604 putative substrate binding site [chemical binding]; other site 1144275017605 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275017606 putative catalytic site [active] 1144275017607 putative metal binding site [ion binding]; other site 1144275017608 putative phosphate binding site [ion binding]; other site 1144275017609 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1144275017610 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1144275017611 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1144275017612 Ligand binding site; other site 1144275017613 metal-binding site 1144275017614 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1144275017615 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1144275017616 active site 1144275017617 dimer interface [polypeptide binding]; other site 1144275017618 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1144275017619 Repair protein; Region: Repair_PSII; cl01535 1144275017620 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275017621 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1144275017622 active site 1144275017623 metal binding site [ion binding]; metal-binding site 1144275017624 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275017625 metal ion-dependent adhesion site (MIDAS); other site 1144275017626 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275017627 metal ion-dependent adhesion site (MIDAS); other site 1144275017628 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1144275017629 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1144275017630 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1144275017631 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1144275017632 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1144275017633 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1144275017634 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275017635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275017636 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275017637 Protein kinase domain; Region: Pkinase; pfam00069 1144275017638 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275017639 active site 1144275017640 ATP binding site [chemical binding]; other site 1144275017641 substrate binding site [chemical binding]; other site 1144275017642 activation loop (A-loop); other site 1144275017643 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275017644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275017645 TPR repeat; Region: TPR_11; pfam13414 1144275017646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275017647 binding surface 1144275017648 TPR motif; other site 1144275017649 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1144275017650 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1144275017651 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1144275017652 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275017653 Penicillin amidase; Region: Penicil_amidase; pfam01804 1144275017654 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275017655 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1144275017656 active site 1144275017657 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1144275017658 RecX family; Region: RecX; cl00936 1144275017659 Cupin domain; Region: Cupin_2; cl09118 1144275017660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275017662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017663 short chain dehydrogenase; Provisional; Region: PRK06180 1144275017664 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1144275017665 NADP binding site [chemical binding]; other site 1144275017666 active site 1144275017667 steroid binding site; other site 1144275017668 YCII-related domain; Region: YCII; cl00999 1144275017669 short chain dehydrogenase; Provisional; Region: PRK12939 1144275017670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017671 NAD(P) binding site [chemical binding]; other site 1144275017672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017673 active site 1144275017674 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1144275017675 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 1144275017676 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275017677 active site 1144275017678 HIGH motif; other site 1144275017679 nucleotide binding site [chemical binding]; other site 1144275017680 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275017681 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275017682 active site 1144275017683 KMSKS motif; other site 1144275017684 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1144275017685 tRNA binding surface [nucleotide binding]; other site 1144275017686 anticodon binding site; other site 1144275017687 aminoacyl-tRNA ligase; Region: PLN02882 1144275017688 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1144275017689 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275017690 N-terminal plug; other site 1144275017691 ligand-binding site [chemical binding]; other site 1144275017692 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1144275017693 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1144275017694 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 1144275017695 short chain dehydrogenase; Provisional; Region: PRK06180 1144275017696 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1144275017697 NADP binding site [chemical binding]; other site 1144275017698 active site 1144275017699 steroid binding site; other site 1144275017700 Helix-turn-helix domains; Region: HTH; cl00088 1144275017701 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1144275017702 Cupin domain; Region: Cupin_2; cl09118 1144275017703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275017705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017706 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275017707 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1144275017708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017709 NAD(P) binding site [chemical binding]; other site 1144275017710 active site 1144275017711 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1144275017712 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 1144275017713 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1144275017714 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1144275017715 heterodimer interface [polypeptide binding]; other site 1144275017716 substrate interaction site [chemical binding]; other site 1144275017717 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275017718 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1144275017719 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1144275017720 active site 1144275017721 substrate binding site [chemical binding]; other site 1144275017722 coenzyme B12 binding site [chemical binding]; other site 1144275017723 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1144275017724 B12 binding site [chemical binding]; other site 1144275017725 cobalt ligand [ion binding]; other site 1144275017726 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1144275017727 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1144275017728 Walker A; other site 1144275017729 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1144275017730 B12 binding site [chemical binding]; other site 1144275017731 cobalt ligand [ion binding]; other site 1144275017732 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1144275017733 Walker A; other site 1144275017734 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1144275017735 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1144275017736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017737 NAD(P) binding site [chemical binding]; other site 1144275017738 active site 1144275017739 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1144275017740 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1144275017741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017742 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1144275017743 dinuclear metal binding motif [ion binding]; other site 1144275017744 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 1144275017745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275017746 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275017747 putative catalytic site [active] 1144275017748 putative metal binding site [ion binding]; other site 1144275017749 putative phosphate binding site [ion binding]; other site 1144275017750 Family description; Region: VCBS; pfam13517 1144275017751 Family description; Region: VCBS; pfam13517 1144275017752 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1144275017753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275017754 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1144275017755 active site 1144275017756 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275017757 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275017758 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275017759 EamA-like transporter family; Region: EamA; cl01037 1144275017760 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1144275017761 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1144275017762 active site 1144275017763 Zn binding site [ion binding]; other site 1144275017764 D-mannose binding lectin; Region: B_lectin; pfam01453 1144275017765 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1144275017766 dimerization interface [polypeptide binding]; other site 1144275017767 mannose binding site [chemical binding]; other site 1144275017768 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1144275017769 Fibronectin type III-like domain; Region: Fn3-like; cl15273 1144275017770 Glycoside hydrolase family 71; Region: GH71; cd11577 1144275017771 putative ligand binding site [chemical binding]; other site 1144275017772 putative catalytic site [active] 1144275017773 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1144275017774 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275017775 active site 1144275017776 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; cl01461 1144275017777 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1144275017778 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1144275017779 NAD(P) binding site [chemical binding]; other site 1144275017780 substrate binding site [chemical binding]; other site 1144275017781 dimer interface [polypeptide binding]; other site 1144275017782 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275017783 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1144275017784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275017785 DNA-binding site [nucleotide binding]; DNA binding site 1144275017786 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275017787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275017788 homodimer interface [polypeptide binding]; other site 1144275017789 catalytic residue [active] 1144275017790 Cupin domain; Region: Cupin_2; cl09118 1144275017791 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275017792 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275017793 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275017794 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1144275017795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275017796 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1144275017797 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1144275017798 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 1144275017799 oligomerization interface [polypeptide binding]; other site 1144275017800 active site 1144275017801 NAD+ binding site [chemical binding]; other site 1144275017802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017803 NAD(P) binding site [chemical binding]; other site 1144275017804 active site 1144275017805 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1144275017806 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1144275017807 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1144275017808 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1144275017809 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1144275017810 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275017811 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1144275017812 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275017813 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1144275017814 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1144275017815 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1144275017816 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1144275017817 PAS domain S-box; Region: sensory_box; TIGR00229 1144275017818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275017819 putative active site [active] 1144275017820 heme pocket [chemical binding]; other site 1144275017821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275017822 dimer interface [polypeptide binding]; other site 1144275017823 phosphorylation site [posttranslational modification] 1144275017824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275017825 ATP binding site [chemical binding]; other site 1144275017826 Mg2+ binding site [ion binding]; other site 1144275017827 G-X-G motif; other site 1144275017828 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1144275017829 Ligand Binding Site [chemical binding]; other site 1144275017830 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275017831 Ligand Binding Site [chemical binding]; other site 1144275017832 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275017833 Ligand Binding Site [chemical binding]; other site 1144275017834 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1144275017835 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275017836 tetramer interface [polypeptide binding]; other site 1144275017837 catalytic Zn binding site [ion binding]; other site 1144275017838 NADP binding site [chemical binding]; other site 1144275017839 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1144275017840 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1144275017841 Helix-turn-helix domains; Region: HTH; cl00088 1144275017842 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1144275017843 dimerization interface [polypeptide binding]; other site 1144275017844 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1144275017845 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1144275017846 tetramer interface [polypeptide binding]; other site 1144275017847 heme binding pocket [chemical binding]; other site 1144275017848 NADPH binding site [chemical binding]; other site 1144275017849 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1144275017850 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1144275017851 transketolase; Reviewed; Region: PRK05899 1144275017852 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1144275017853 TPP-binding site [chemical binding]; other site 1144275017854 dimer interface [polypeptide binding]; other site 1144275017855 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1144275017856 PYR/PP interface [polypeptide binding]; other site 1144275017857 dimer interface [polypeptide binding]; other site 1144275017858 TPP binding site [chemical binding]; other site 1144275017859 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1144275017860 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1144275017861 putative active site [active] 1144275017862 transaldolase; Provisional; Region: PRK03903 1144275017863 catalytic residue [active] 1144275017864 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 1144275017865 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1144275017866 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1144275017867 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1144275017868 putative active site [active] 1144275017869 GAF domain; Region: GAF; cl15785 1144275017870 GAF domain; Region: GAF_2; pfam13185 1144275017871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275017872 dimer interface [polypeptide binding]; other site 1144275017873 phosphorylation site [posttranslational modification] 1144275017874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275017875 ATP binding site [chemical binding]; other site 1144275017876 Mg2+ binding site [ion binding]; other site 1144275017877 G-X-G motif; other site 1144275017878 putative lyase; Provisional; Region: PRK09687 1144275017879 putative lyase; Provisional; Region: PRK09687 1144275017880 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275017881 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1144275017882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275017883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017884 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1144275017885 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275017886 NAD binding site [chemical binding]; other site 1144275017887 catalytic Zn binding site [ion binding]; other site 1144275017888 structural Zn binding site [ion binding]; other site 1144275017889 5'-3' exonuclease; Region: 53EXOc; smart00475 1144275017890 polysaccharide export protein Wza; Provisional; Region: PRK15078 1144275017891 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1144275017892 SLBB domain; Region: SLBB; pfam10531 1144275017893 tyrosine kinase; Provisional; Region: PRK11519 1144275017894 Chain length determinant protein; Region: Wzz; cl15801 1144275017895 Chain length determinant protein; Region: Wzz; cl15801 1144275017896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275017897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275017898 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1144275017899 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1144275017900 Bacterial sugar transferase; Region: Bac_transf; cl00939 1144275017901 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1144275017902 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1144275017903 inhibitor-cofactor binding pocket; inhibition site 1144275017904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275017905 catalytic residue [active] 1144275017906 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275017907 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1144275017908 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1144275017909 NAD(P) binding site [chemical binding]; other site 1144275017910 homodimer interface [polypeptide binding]; other site 1144275017911 substrate binding site [chemical binding]; other site 1144275017912 active site 1144275017913 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1144275017914 catalytic core [active] 1144275017915 Helix-turn-helix domains; Region: HTH; cl00088 1144275017916 DNA binding site [nucleotide binding] 1144275017917 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1144275017918 cleavage site 1144275017919 active site 1144275017920 substrate binding sites [chemical binding]; other site 1144275017921 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1144275017922 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275017923 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1144275017924 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275017925 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1144275017926 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1144275017927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017928 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1144275017929 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1144275017930 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1144275017931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017932 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1144275017933 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1144275017934 cyclase homology domain; Region: CHD; cd07302 1144275017935 nucleotidyl binding site; other site 1144275017936 metal binding site [ion binding]; metal-binding site 1144275017937 dimer interface [polypeptide binding]; other site 1144275017938 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1144275017939 cyclase homology domain; Region: CHD; cd07302 1144275017940 dimer interface [polypeptide binding]; other site 1144275017941 nucleotidyl binding site; other site 1144275017942 metal binding site [ion binding]; metal-binding site 1144275017943 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 1144275017944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275017945 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1144275017946 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1144275017947 Short C-terminal domain; Region: SHOCT; cl01373 1144275017948 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1144275017949 active site 1144275017950 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1144275017951 putative ligand binding residues [chemical binding]; other site 1144275017952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1144275017953 ABC-ATPase subunit interface; other site 1144275017954 dimer interface [polypeptide binding]; other site 1144275017955 putative PBP binding regions; other site 1144275017956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1144275017957 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1144275017958 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1144275017959 Walker A/P-loop; other site 1144275017960 ATP binding site [chemical binding]; other site 1144275017961 Q-loop/lid; other site 1144275017962 ABC transporter signature motif; other site 1144275017963 Walker B; other site 1144275017964 D-loop; other site 1144275017965 H-loop/switch region; other site 1144275017966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1144275017967 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1144275017968 active site 1144275017969 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275017970 active site 1144275017971 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275017972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275017973 Helix-turn-helix domains; Region: HTH; cl00088 1144275017974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275017975 dimerization interface [polypeptide binding]; other site 1144275017976 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1144275017977 putative active site [active] 1144275017978 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1144275017979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017980 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1144275017981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1144275017982 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 1144275017983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275017984 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275017985 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1144275017986 DNA binding residues [nucleotide binding] 1144275017987 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1144275017988 putative dimer interface [polypeptide binding]; other site 1144275017989 putative metal binding residues [ion binding]; other site 1144275017990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275017991 S-adenosylmethionine binding site [chemical binding]; other site 1144275017992 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1144275017993 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275017994 NAD(P) binding site [chemical binding]; other site 1144275017995 catalytic residues [active] 1144275017996 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1144275017997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275017998 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1144275017999 LysE type translocator; Region: LysE; cl00565 1144275018000 multidrug efflux protein; Reviewed; Region: PRK09579 1144275018001 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275018002 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275018003 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275018004 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 1144275018005 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1144275018006 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275018007 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275018008 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275018009 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1144275018010 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1144275018012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018013 Q-loop/lid; other site 1144275018014 ABC transporter signature motif; other site 1144275018015 Walker B; other site 1144275018016 D-loop; other site 1144275018017 H-loop/switch region; other site 1144275018018 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275018019 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1144275018020 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275018021 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275018022 catalytic residue [active] 1144275018023 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1144275018024 sucrose phosphorylase; Provisional; Region: PRK13840 1144275018025 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1144275018026 active site 1144275018027 catalytic site [active] 1144275018028 hypothetical protein; Provisional; Region: PRK05849 1144275018029 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1144275018030 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1144275018031 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1144275018032 conserved cys residue [active] 1144275018033 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1144275018034 active site 1144275018035 metal-binding site 1144275018036 RNA polymerase sigma factor; Provisional; Region: PRK11924 1144275018037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275018038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1144275018039 active site 1144275018040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1144275018041 active site 1144275018042 Phage Tail Collar Domain; Region: Collar; pfam07484 1144275018043 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1144275018044 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275018045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275018046 ATP binding site [chemical binding]; other site 1144275018047 Walker B motif; other site 1144275018048 arginine finger; other site 1144275018049 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1144275018050 GIY-YIG motif/motif A; other site 1144275018051 active site 1144275018052 catalytic site [active] 1144275018053 metal binding site [ion binding]; metal-binding site 1144275018054 Transposase domain (DUF772); Region: DUF772; pfam05598 1144275018055 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1144275018056 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1144275018057 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1144275018058 putative sugar binding sites [chemical binding]; other site 1144275018059 Q-X-W motif; other site 1144275018060 Helix-turn-helix domains; Region: HTH; cl00088 1144275018061 WHG domain; Region: WHG; pfam13305 1144275018062 Predicted membrane protein [Function unknown]; Region: COG2311 1144275018063 Protein of unknown function (DUF418); Region: DUF418; cl12135 1144275018064 Protein of unknown function (DUF418); Region: DUF418; cl12135 1144275018065 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275018066 Jacalin-like lectin domain; Region: Jacalin_like; cl03205 1144275018067 putative sugar binding site [chemical binding]; other site 1144275018068 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275018069 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1144275018070 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275018071 ligand binding site [chemical binding]; other site 1144275018072 flexible hinge region; other site 1144275018073 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1144275018074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275018075 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275018076 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275018077 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275018078 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1144275018079 active site 1144275018080 DNA binding site [nucleotide binding] 1144275018081 Int/Topo IB signature motif; other site 1144275018082 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1144275018083 polymerase nucleotide-binding site; other site 1144275018084 DNA-binding residues [nucleotide binding]; DNA binding site 1144275018085 nucleotide binding site [chemical binding]; other site 1144275018086 primase nucleotide-binding site [nucleotide binding]; other site 1144275018087 Domain of unknown function (DUF927); Region: DUF927; cl12098 1144275018088 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275018089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018091 active site 1144275018092 ATP binding site [chemical binding]; other site 1144275018093 substrate binding site [chemical binding]; other site 1144275018094 activation loop (A-loop); other site 1144275018095 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 1144275018096 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018097 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018098 active site 1144275018099 ATP binding site [chemical binding]; other site 1144275018100 substrate binding site [chemical binding]; other site 1144275018101 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275018102 substrate binding site [chemical binding]; other site 1144275018103 activation loop (A-loop); other site 1144275018104 activation loop (A-loop); other site 1144275018105 response regulator PleD; Reviewed; Region: pleD; PRK09581 1144275018106 zinc-finger of acetyl-transferase ESCO; Region: zf-C2H2_3; pfam13878 1144275018107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275018108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018109 binding surface 1144275018110 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275018111 TPR motif; other site 1144275018112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275018113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018114 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018115 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018116 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018117 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018118 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018119 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275018120 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275018121 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275018122 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1144275018123 hypothetical protein; Provisional; Region: PRK08204 1144275018124 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275018125 active site 1144275018126 Helix-turn-helix domains; Region: HTH; cl00088 1144275018127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275018128 Helix-turn-helix domains; Region: HTH; cl00088 1144275018129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275018130 dimerization interface [polypeptide binding]; other site 1144275018131 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 1144275018132 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275018133 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 1144275018134 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1144275018135 active site 2 [active] 1144275018136 active site 1 [active] 1144275018137 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1144275018138 active site 1144275018139 catalytic site [active] 1144275018140 Cupin domain; Region: Cupin_2; cl09118 1144275018141 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1144275018142 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1144275018143 dimer interface [polypeptide binding]; other site 1144275018144 active site 1144275018145 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 1144275018146 active site flap/lid [active] 1144275018147 nucleophilic elbow; other site 1144275018148 catalytic triad [active] 1144275018149 Helix-turn-helix domains; Region: HTH; cl00088 1144275018150 Integrase core domain; Region: rve; cl01316 1144275018151 Integrase core domain; Region: rve_3; cl15866 1144275018152 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1144275018153 DDE superfamily endonuclease; Region: DDE_5; cl02413 1144275018154 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1144275018155 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275018156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275018157 active site 1144275018158 phosphorylation site [posttranslational modification] 1144275018159 intermolecular recognition site; other site 1144275018160 dimerization interface [polypeptide binding]; other site 1144275018161 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1144275018162 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1144275018163 substrate binding site [chemical binding]; other site 1144275018164 hexamer interface [polypeptide binding]; other site 1144275018165 metal binding site [ion binding]; metal-binding site 1144275018166 GAF domain; Region: GAF; cl15785 1144275018167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275018168 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1144275018169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1144275018170 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1144275018171 pyruvate kinase; Provisional; Region: PRK05826 1144275018172 domain interfaces; other site 1144275018173 active site 1144275018174 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1144275018175 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1144275018176 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1144275018177 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1144275018178 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1144275018179 FMN binding site [chemical binding]; other site 1144275018180 active site 1144275018181 catalytic residues [active] 1144275018182 substrate binding site [chemical binding]; other site 1144275018183 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1144275018184 active site 1144275018185 putative substrate binding region [chemical binding]; other site 1144275018186 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275018187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275018188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275018189 DNA binding residues [nucleotide binding] 1144275018190 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1144275018191 catalytic triad [active] 1144275018192 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1144275018193 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 1144275018194 Cl- selectivity filter; other site 1144275018195 Cl- binding residues [ion binding]; other site 1144275018196 pore gating glutamate residue; other site 1144275018197 dimer interface [polypeptide binding]; other site 1144275018198 FOG: CBS domain [General function prediction only]; Region: COG0517 1144275018199 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1144275018200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1144275018201 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1144275018202 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1144275018203 catalytic triad [active] 1144275018204 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1144275018205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1144275018206 active site 1144275018207 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275018208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018209 active site 1144275018210 ATP binding site [chemical binding]; other site 1144275018211 substrate binding site [chemical binding]; other site 1144275018212 activation loop (A-loop); other site 1144275018213 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275018214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018215 TPR motif; other site 1144275018216 binding surface 1144275018217 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1144275018218 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1144275018219 GAF domain; Region: GAF_2; pfam13185 1144275018220 GAF domain; Region: GAF; cl15785 1144275018221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1144275018222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018223 ATP binding site [chemical binding]; other site 1144275018224 Mg2+ binding site [ion binding]; other site 1144275018225 G-X-G motif; other site 1144275018226 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1144275018227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275018228 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1144275018229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275018230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018231 active site 1144275018232 ATP binding site [chemical binding]; other site 1144275018233 substrate binding site [chemical binding]; other site 1144275018234 activation loop (A-loop); other site 1144275018235 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1144275018236 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275018237 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1144275018238 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 1144275018239 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1144275018240 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1144275018241 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1144275018242 NAD binding site [chemical binding]; other site 1144275018243 catalytic Zn binding site [ion binding]; other site 1144275018244 structural Zn binding site [ion binding]; other site 1144275018245 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1144275018246 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1144275018247 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1144275018248 classical (c) SDRs; Region: SDR_c; cd05233 1144275018249 NAD(P) binding site [chemical binding]; other site 1144275018250 active site 1144275018251 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1144275018252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275018253 non-specific DNA binding site [nucleotide binding]; other site 1144275018254 salt bridge; other site 1144275018255 sequence-specific DNA binding site [nucleotide binding]; other site 1144275018256 Cupin domain; Region: Cupin_2; cl09118 1144275018257 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018258 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018259 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018260 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1144275018261 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1144275018262 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275018263 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1144275018264 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 1144275018265 putative ADP-ribose binding site [chemical binding]; other site 1144275018266 putative active site [active] 1144275018267 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1144275018268 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1144275018269 PAS domain; Region: PAS_9; pfam13426 1144275018270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275018271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018272 ATP binding site [chemical binding]; other site 1144275018273 Mg2+ binding site [ion binding]; other site 1144275018274 G-X-G motif; other site 1144275018275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275018276 active site 1144275018277 phosphorylation site [posttranslational modification] 1144275018278 intermolecular recognition site; other site 1144275018279 dimerization interface [polypeptide binding]; other site 1144275018280 Predicted integral membrane protein (DUF2270); Region: DUF2270; cl02337 1144275018281 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1144275018282 tartrate dehydrogenase; Provisional; Region: PRK08194 1144275018283 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1144275018284 putative rRNA binding site [nucleotide binding]; other site 1144275018285 Vitamin K epoxide reductase family; Region: VKOR; cl01729 1144275018286 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275018287 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1144275018288 Cupin domain; Region: Cupin_2; cl09118 1144275018289 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1144275018290 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1144275018291 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1144275018292 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1144275018293 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1144275018294 dimer interface [polypeptide binding]; other site 1144275018295 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1144275018296 active site 1144275018297 Fe binding site [ion binding]; other site 1144275018298 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1144275018299 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1144275018300 C-terminal domain interface [polypeptide binding]; other site 1144275018301 GSH binding site (G-site) [chemical binding]; other site 1144275018302 putative dimer interface [polypeptide binding]; other site 1144275018303 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1144275018304 dimer interface [polypeptide binding]; other site 1144275018305 N-terminal domain interface [polypeptide binding]; other site 1144275018306 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1144275018307 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1144275018308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1144275018309 Protein kinase domain; Region: Pkinase; pfam00069 1144275018310 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018311 active site 1144275018312 ATP binding site [chemical binding]; other site 1144275018313 substrate binding site [chemical binding]; other site 1144275018314 activation loop (A-loop); other site 1144275018315 Predicted ATPase [General function prediction only]; Region: COG3899 1144275018316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275018317 GAF domain; Region: GAF; cl15785 1144275018318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275018319 dimer interface [polypeptide binding]; other site 1144275018320 phosphorylation site [posttranslational modification] 1144275018321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018322 ATP binding site [chemical binding]; other site 1144275018323 Mg2+ binding site [ion binding]; other site 1144275018324 G-X-G motif; other site 1144275018325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275018326 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275018327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1144275018328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018329 ATP binding site [chemical binding]; other site 1144275018330 Mg2+ binding site [ion binding]; other site 1144275018331 G-X-G motif; other site 1144275018332 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1144275018333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275018334 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1144275018335 L-serine binding site [chemical binding]; other site 1144275018336 ACT domain interface; other site 1144275018337 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1144275018338 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275018339 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1144275018340 FAD binding pocket [chemical binding]; other site 1144275018341 FAD binding motif [chemical binding]; other site 1144275018342 phosphate binding motif [ion binding]; other site 1144275018343 NAD binding pocket [chemical binding]; other site 1144275018344 Helix-turn-helix domains; Region: HTH; cl00088 1144275018345 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1144275018346 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1144275018347 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1144275018348 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275018349 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1144275018350 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1144275018351 catalytic residue [active] 1144275018352 GXWXG protein; Region: GXWXG; pfam14231 1144275018353 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1144275018354 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1144275018355 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1144275018356 catalytic Zn binding site [ion binding]; other site 1144275018357 NAD binding site [chemical binding]; other site 1144275018358 structural Zn binding site [ion binding]; other site 1144275018359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018360 TPR motif; other site 1144275018361 binding surface 1144275018362 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275018363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018364 TPR motif; other site 1144275018365 binding surface 1144275018366 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275018367 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1144275018368 active site 1144275018369 trimer interface [polypeptide binding]; other site 1144275018370 allosteric site; other site 1144275018371 active site lid [active] 1144275018372 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1144275018373 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1144275018374 active site 1144275018375 ADP/pyrophosphate binding site [chemical binding]; other site 1144275018376 dimerization interface [polypeptide binding]; other site 1144275018377 allosteric effector site; other site 1144275018378 fructose-1,6-bisphosphate binding site; other site 1144275018379 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1144275018380 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275018381 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275018382 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275018383 phosphopeptide binding site; other site 1144275018384 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1144275018385 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275018386 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1144275018387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275018388 putative active site [active] 1144275018389 putative metal binding site [ion binding]; other site 1144275018390 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275018391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275018392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018393 binding surface 1144275018394 TPR motif; other site 1144275018395 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275018396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275018397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1144275018398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018399 TPR motif; other site 1144275018400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275018401 binding surface 1144275018402 CHAT domain; Region: CHAT; pfam12770 1144275018403 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1144275018404 intersubunit interface [polypeptide binding]; other site 1144275018405 active site 1144275018406 Zn2+ binding site [ion binding]; other site 1144275018407 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1144275018408 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1144275018409 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1144275018410 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1144275018411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275018412 motif II; other site 1144275018413 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1144275018414 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1144275018415 intersubunit interface [polypeptide binding]; other site 1144275018416 active site 1144275018417 Zn2+ binding site [ion binding]; other site 1144275018418 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275018419 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018420 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018421 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018422 active site 1144275018423 ATP binding site [chemical binding]; other site 1144275018424 substrate binding site [chemical binding]; other site 1144275018425 activation loop (A-loop); other site 1144275018426 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1144275018427 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1144275018428 Ligand Binding Site [chemical binding]; other site 1144275018429 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018430 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018431 active site 1144275018432 ATP binding site [chemical binding]; other site 1144275018433 substrate binding site [chemical binding]; other site 1144275018434 activation loop (A-loop); other site 1144275018435 cyclase homology domain; Region: CHD; cd07302 1144275018436 nucleotidyl binding site; other site 1144275018437 metal binding site [ion binding]; metal-binding site 1144275018438 dimer interface [polypeptide binding]; other site 1144275018439 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275018440 NlpC/P60 family; Region: NLPC_P60; cl11438 1144275018441 NlpC/P60 family; Region: NLPC_P60; cl11438 1144275018442 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1144275018443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275018444 Coenzyme A binding pocket [chemical binding]; other site 1144275018445 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1144275018446 endonuclease III; Region: ENDO3c; smart00478 1144275018447 minor groove reading motif; other site 1144275018448 helix-hairpin-helix signature motif; other site 1144275018449 substrate binding pocket [chemical binding]; other site 1144275018450 active site 1144275018451 cardiolipin synthase 2; Provisional; Region: PRK11263 1144275018452 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1144275018453 putative active site [active] 1144275018454 catalytic site [active] 1144275018455 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1144275018456 putative active site [active] 1144275018457 catalytic site [active] 1144275018458 acyl-coenzyme A oxidase; Region: PLN02636 1144275018459 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1144275018460 active site 1144275018461 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275018462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275018463 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 1144275018464 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1144275018465 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1144275018466 putative active site [active] 1144275018467 putative metal binding site [ion binding]; other site 1144275018468 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1144275018469 Clp protease; Region: CLP_protease; pfam00574 1144275018470 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1144275018471 oligomer interface [polypeptide binding]; other site 1144275018472 active site residues [active] 1144275018473 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1144275018474 Class II fumarases; Region: Fumarase_classII; cd01362 1144275018475 active site 1144275018476 tetramer interface [polypeptide binding]; other site 1144275018477 MOSC domain; Region: MOSC; pfam03473 1144275018478 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275018479 putative active site [active] 1144275018480 putative DNA polymerase catalytic subunit; Provisional; Region: PHA03334 1144275018481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275018482 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275018483 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275018484 dimer interface [polypeptide binding]; other site 1144275018485 putative CheW interface [polypeptide binding]; other site 1144275018486 PspC domain; Region: PspC; cl00864 1144275018487 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1144275018488 malate synthase A; Region: malate_syn_A; TIGR01344 1144275018489 active site 1144275018490 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1144275018491 tetramer interface [polypeptide binding]; other site 1144275018492 active site 1144275018493 Mg2+/Mn2+ binding site [ion binding]; other site 1144275018494 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 1144275018495 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1144275018496 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275018497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275018498 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275018499 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1144275018500 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1144275018501 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275018502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275018503 dimer interface [polypeptide binding]; other site 1144275018504 putative CheW interface [polypeptide binding]; other site 1144275018505 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1144275018506 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1144275018507 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275018508 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1144275018509 classical (c) SDRs; Region: SDR_c; cd05233 1144275018510 NAD(P) binding site [chemical binding]; other site 1144275018511 active site 1144275018512 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 1144275018513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275018514 FeS/SAM binding site; other site 1144275018515 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275018516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275018517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275018518 DNA binding residues [nucleotide binding] 1144275018519 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1144275018520 active site 1144275018521 DNA binding site [nucleotide binding] 1144275018522 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1144275018523 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275018524 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 1144275018525 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275018526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1144275018527 Family of unknown function (DUF490); Region: DUF490; pfam04357 1144275018528 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1144275018529 active site 1144275018530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275018531 DNA binding residues [nucleotide binding] 1144275018532 dimerization interface [polypeptide binding]; other site 1144275018533 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275018534 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1144275018535 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1144275018536 metal ion-dependent adhesion site (MIDAS); other site 1144275018537 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1144275018538 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275018539 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1144275018540 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1144275018541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018542 Walker A/P-loop; other site 1144275018543 ATP binding site [chemical binding]; other site 1144275018544 Q-loop/lid; other site 1144275018545 ABC transporter signature motif; other site 1144275018546 Walker B; other site 1144275018547 D-loop; other site 1144275018548 H-loop/switch region; other site 1144275018549 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275018550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275018551 Walker A motif; other site 1144275018552 ATP binding site [chemical binding]; other site 1144275018553 Walker B motif; other site 1144275018554 arginine finger; other site 1144275018555 Predicted ATPases [General function prediction only]; Region: COG1106 1144275018556 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018557 Walker A/P-loop; other site 1144275018558 ATP binding site [chemical binding]; other site 1144275018559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018560 Q-loop/lid; other site 1144275018561 ABC transporter signature motif; other site 1144275018562 Walker B; other site 1144275018563 D-loop; other site 1144275018564 H-loop/switch region; other site 1144275018565 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275018566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275018567 active site 1144275018568 catalytic tetrad [active] 1144275018569 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275018570 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275018571 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275018572 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275018573 Helix-turn-helix domains; Region: HTH; cl00088 1144275018574 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1144275018575 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1144275018576 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1144275018577 iron-sulfur cluster [ion binding]; other site 1144275018578 [2Fe-2S] cluster binding site [ion binding]; other site 1144275018579 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1144275018580 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1144275018581 Ycf48-like protein; Provisional; Region: PRK13684 1144275018582 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1144275018583 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1144275018584 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1144275018585 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1144275018586 active site 1144275018587 substrate binding site [chemical binding]; other site 1144275018588 metal binding site [ion binding]; metal-binding site 1144275018589 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018590 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018591 active site 1144275018592 ATP binding site [chemical binding]; other site 1144275018593 substrate binding site [chemical binding]; other site 1144275018594 activation loop (A-loop); other site 1144275018595 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275018596 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1144275018597 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1144275018598 Substrate binding site; other site 1144275018599 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1144275018600 homotrimer interaction site [polypeptide binding]; other site 1144275018601 putative active site [active] 1144275018602 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1144275018603 active site 1144275018604 oxyanion hole [active] 1144275018605 catalytic triad [active] 1144275018606 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 1144275018607 active site 1144275018608 oxyanion hole [active] 1144275018609 catalytic triad [active] 1144275018610 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1144275018611 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1144275018612 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275018613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275018614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275018615 dimer interface [polypeptide binding]; other site 1144275018616 phosphorylation site [posttranslational modification] 1144275018617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018618 ATP binding site [chemical binding]; other site 1144275018619 Mg2+ binding site [ion binding]; other site 1144275018620 G-X-G motif; other site 1144275018621 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275018622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275018623 active site 1144275018624 phosphorylation site [posttranslational modification] 1144275018625 intermolecular recognition site; other site 1144275018626 dimerization interface [polypeptide binding]; other site 1144275018627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275018628 Walker A motif; other site 1144275018629 ATP binding site [chemical binding]; other site 1144275018630 Walker B motif; other site 1144275018631 arginine finger; other site 1144275018632 Helix-turn-helix domains; Region: HTH; cl00088 1144275018633 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1144275018634 Surface antigen; Region: Bac_surface_Ag; cl03097 1144275018635 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1144275018636 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1144275018637 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1144275018638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275018639 S-adenosylmethionine binding site [chemical binding]; other site 1144275018640 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1144275018641 putative active site [active] 1144275018642 putative CoA binding site [chemical binding]; other site 1144275018643 nudix motif; other site 1144275018644 metal binding site [ion binding]; metal-binding site 1144275018645 Bacitracin resistance protein BacA; Region: BacA; cl00858 1144275018646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1144275018647 SEC-C motif; Region: SEC-C; pfam02810 1144275018648 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1144275018649 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1144275018650 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1144275018651 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1144275018652 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1144275018653 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 1144275018654 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1144275018655 active site 1144275018656 substrate binding site [chemical binding]; other site 1144275018657 cosubstrate binding site; other site 1144275018658 catalytic site [active] 1144275018659 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1144275018660 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1144275018661 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1144275018662 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1144275018663 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1144275018664 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 1144275018665 Site-specific recombinase; Region: SpecificRecomb; cl15411 1144275018666 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1144275018667 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1144275018668 MgtC family; Region: MgtC; pfam02308 1144275018669 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1144275018670 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1144275018671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1144275018672 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1144275018673 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1144275018674 dimerization domain swap beta strand [polypeptide binding]; other site 1144275018675 regulatory protein interface [polypeptide binding]; other site 1144275018676 active site 1144275018677 regulatory phosphorylation site [posttranslational modification]; other site 1144275018678 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1144275018679 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 1144275018680 active site 1144275018681 phosphorylation site [posttranslational modification] 1144275018682 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1144275018683 active pocket/dimerization site; other site 1144275018684 active site 1144275018685 phosphorylation site [posttranslational modification] 1144275018686 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1144275018687 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1144275018688 MAEBL; Provisional; Region: PTZ00121 1144275018689 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275018690 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1144275018691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018692 TPR motif; other site 1144275018693 binding surface 1144275018694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275018695 S-adenosylmethionine binding site [chemical binding]; other site 1144275018696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018697 Walker A motif; other site 1144275018698 ATP binding site [chemical binding]; other site 1144275018699 Walker B motif; other site 1144275018700 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1144275018701 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1144275018702 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1144275018703 DRTGG domain; Region: DRTGG; cl12147 1144275018704 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1144275018705 Hpr binding site; other site 1144275018706 active site 1144275018707 homohexamer subunit interaction site [polypeptide binding]; other site 1144275018708 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275018709 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1144275018710 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1144275018711 nucleotide binding site/active site [active] 1144275018712 HIT family signature motif; other site 1144275018713 catalytic residue [active] 1144275018714 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 1144275018715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275018716 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018718 active site 1144275018719 ATP binding site [chemical binding]; other site 1144275018720 substrate binding site [chemical binding]; other site 1144275018721 activation loop (A-loop); other site 1144275018722 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 1144275018723 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275018724 phosphopeptide binding site; other site 1144275018725 GAF domain; Region: GAF_2; pfam13185 1144275018726 GAF domain; Region: GAF; cl15785 1144275018727 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1144275018728 cyclase homology domain; Region: CHD; cd07302 1144275018729 nucleotidyl binding site; other site 1144275018730 metal binding site [ion binding]; metal-binding site 1144275018731 dimer interface [polypeptide binding]; other site 1144275018732 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1144275018733 iron-sulfur cluster [ion binding]; other site 1144275018734 [2Fe-2S] cluster binding site [ion binding]; other site 1144275018735 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1144275018736 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1144275018737 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1144275018738 Beta propeller domain; Region: Beta_propel; pfam09826 1144275018739 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275018740 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275018741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275018742 Helix-turn-helix domains; Region: HTH; cl00088 1144275018743 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275018744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275018745 active site 1144275018746 catalytic tetrad [active] 1144275018747 Protein of unknown function, DUF655; Region: DUF655; pfam04919 1144275018748 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1144275018749 Helix-turn-helix domains; Region: HTH; cl00088 1144275018750 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1144275018751 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1144275018752 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275018753 TPR repeat; Region: TPR_11; pfam13414 1144275018754 Domain of unknown function (DUF305); Region: DUF305; cl15795 1144275018755 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1144275018756 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018757 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1144275018758 PilZ domain; Region: PilZ; cl01260 1144275018759 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275018760 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1144275018761 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1144275018762 putative active site [active] 1144275018763 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018764 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1144275018765 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018766 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1144275018767 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1144275018768 putative NAD(P) binding site [chemical binding]; other site 1144275018769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275018770 Helix-turn-helix domains; Region: HTH; cl00088 1144275018771 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1144275018772 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275018773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275018774 Walker A motif; other site 1144275018775 ATP binding site [chemical binding]; other site 1144275018776 Walker B motif; other site 1144275018777 arginine finger; other site 1144275018778 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275018779 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275018780 Aerotolerance regulator N-terminal; Region: BatA; cl06567 1144275018781 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275018782 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1144275018783 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1144275018784 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1144275018785 catalytic triad [active] 1144275018786 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275018787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275018788 active site 1144275018789 phosphorylation site [posttranslational modification] 1144275018790 intermolecular recognition site; other site 1144275018791 dimerization interface [polypeptide binding]; other site 1144275018792 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1144275018793 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1144275018794 O-methyltransferase; Region: Methyltransf_2; pfam00891 1144275018795 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275018796 putative active site [active] 1144275018797 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275018798 putative active site [active] 1144275018799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275018800 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1144275018801 putative hydrophobic ligand binding site [chemical binding]; other site 1144275018802 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275018803 dimerization interface [polypeptide binding]; other site 1144275018804 putative DNA binding site [nucleotide binding]; other site 1144275018805 putative Zn2+ binding site [ion binding]; other site 1144275018806 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1144275018807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275018808 DNA-binding site [nucleotide binding]; DNA binding site 1144275018809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275018810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275018811 homodimer interface [polypeptide binding]; other site 1144275018812 catalytic residue [active] 1144275018813 NIPSNAP; Region: NIPSNAP; pfam07978 1144275018814 NIPSNAP; Region: NIPSNAP; pfam07978 1144275018815 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1144275018816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275018817 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1144275018818 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1144275018819 active site 1144275018820 substrate binding site [chemical binding]; other site 1144275018821 Mg2+ binding site [ion binding]; other site 1144275018822 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1144275018823 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1144275018824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275018825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1144275018826 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275018827 Phospholipid methyltransferase; Region: PEMT; cl00763 1144275018828 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1144275018829 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1144275018830 malonyl-CoA binding site [chemical binding]; other site 1144275018831 dimer interface [polypeptide binding]; other site 1144275018832 active site 1144275018833 product binding site; other site 1144275018834 TadE-like protein; Region: TadE; cl10688 1144275018835 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275018836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275018837 NAD(P) binding site [chemical binding]; other site 1144275018838 active site 1144275018839 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1144275018840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275018841 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 1144275018842 putative binding site; other site 1144275018843 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 1144275018844 YhhN-like protein; Region: YhhN; cl01505 1144275018845 HEAT repeats; Region: HEAT_2; pfam13646 1144275018846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018847 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018848 active site 1144275018849 ATP binding site [chemical binding]; other site 1144275018850 substrate binding site [chemical binding]; other site 1144275018851 activation loop (A-loop); other site 1144275018852 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018853 TPR repeat; Region: TPR_11; pfam13414 1144275018854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275018855 binding surface 1144275018856 TPR motif; other site 1144275018857 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275018858 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1144275018859 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1144275018860 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1144275018861 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1144275018862 active site 1144275018863 catalytic site [active] 1144275018864 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 1144275018865 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275018866 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1144275018867 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1144275018868 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1144275018869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275018870 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1144275018871 Walker A/P-loop; other site 1144275018872 ATP binding site [chemical binding]; other site 1144275018873 Q-loop/lid; other site 1144275018874 ABC transporter signature motif; other site 1144275018875 Walker B; other site 1144275018876 D-loop; other site 1144275018877 H-loop/switch region; other site 1144275018878 TOBE domain; Region: TOBE_2; cl01440 1144275018879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1144275018880 dimer interface [polypeptide binding]; other site 1144275018881 conserved gate region; other site 1144275018882 putative PBP binding loops; other site 1144275018883 ABC-ATPase subunit interface; other site 1144275018884 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1144275018885 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275018886 Helix-turn-helix domains; Region: HTH; cl00088 1144275018887 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1144275018888 putative active site [active] 1144275018889 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275018890 putative catalytic site [active] 1144275018891 putative metal binding site [ion binding]; other site 1144275018892 putative phosphate binding site [ion binding]; other site 1144275018893 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1144275018894 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1144275018895 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 1144275018896 dimer interface [polypeptide binding]; other site 1144275018897 motif 1; other site 1144275018898 active site 1144275018899 motif 2; other site 1144275018900 motif 3; other site 1144275018901 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1144275018902 anticodon binding site; other site 1144275018903 zinc-binding site [ion binding]; other site 1144275018904 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1144275018905 cyclase homology domain; Region: CHD; cd07302 1144275018906 nucleotidyl binding site; other site 1144275018907 metal binding site [ion binding]; metal-binding site 1144275018908 dimer interface [polypeptide binding]; other site 1144275018909 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1144275018910 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1144275018911 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1144275018912 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1144275018913 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1144275018914 NMT1-like family; Region: NMT1_2; cl15260 1144275018915 PAS fold; Region: PAS_4; pfam08448 1144275018916 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275018917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275018918 dimer interface [polypeptide binding]; other site 1144275018919 phosphorylation site [posttranslational modification] 1144275018920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018921 ATP binding site [chemical binding]; other site 1144275018922 G-X-G motif; other site 1144275018923 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1144275018924 BNR repeat-like domain; Region: BNR_2; pfam13088 1144275018925 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1144275018926 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1144275018927 Walker A/P-loop; other site 1144275018928 ATP binding site [chemical binding]; other site 1144275018929 Q-loop/lid; other site 1144275018930 ABC transporter signature motif; other site 1144275018931 Walker B; other site 1144275018932 D-loop; other site 1144275018933 H-loop/switch region; other site 1144275018934 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1144275018935 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1144275018936 Walker A/P-loop; other site 1144275018937 ATP binding site [chemical binding]; other site 1144275018938 Q-loop/lid; other site 1144275018939 ABC transporter signature motif; other site 1144275018940 Walker B; other site 1144275018941 D-loop; other site 1144275018942 H-loop/switch region; other site 1144275018943 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1144275018944 TM-ABC transporter signature motif; other site 1144275018945 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1144275018946 TM-ABC transporter signature motif; other site 1144275018947 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1144275018948 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1144275018949 putative ligand binding site [chemical binding]; other site 1144275018950 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1144275018951 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275018952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275018953 active site 1144275018954 ATP binding site [chemical binding]; other site 1144275018955 substrate binding site [chemical binding]; other site 1144275018956 activation loop (A-loop); other site 1144275018957 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1144275018958 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1144275018959 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1144275018960 dimer interface [polypeptide binding]; other site 1144275018961 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1144275018962 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275018963 putative catalytic site [active] 1144275018964 putative metal binding site [ion binding]; other site 1144275018965 putative phosphate binding site [ion binding]; other site 1144275018966 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1144275018967 Lamin Tail Domain; Region: LTD; pfam00932 1144275018968 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275018969 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275018970 Protein kinase domain; Region: Pkinase; pfam00069 1144275018971 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275018972 active site 1144275018973 ATP binding site [chemical binding]; other site 1144275018974 substrate binding site [chemical binding]; other site 1144275018975 activation loop (A-loop); other site 1144275018976 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275018977 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275018978 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1144275018979 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1144275018980 Protein of unknown function DUF111; Region: DUF111; cl03398 1144275018981 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1144275018982 AIR carboxylase; Region: AIRC; cl00310 1144275018983 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1144275018984 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1144275018985 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275018986 putative binding surface; other site 1144275018987 active site 1144275018988 P2 response regulator binding domain; Region: P2; pfam07194 1144275018989 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1144275018990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275018991 ATP binding site [chemical binding]; other site 1144275018992 G-X-G motif; other site 1144275018993 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275018994 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275018995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275018996 active site 1144275018997 phosphorylation site [posttranslational modification] 1144275018998 intermolecular recognition site; other site 1144275018999 dimerization interface [polypeptide binding]; other site 1144275019000 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275019001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019002 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275019003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275019004 dimer interface [polypeptide binding]; other site 1144275019005 putative CheW interface [polypeptide binding]; other site 1144275019006 thiamine monophosphate kinase; Provisional; Region: PRK05731 1144275019007 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1144275019008 ATP binding site [chemical binding]; other site 1144275019009 dimerization interface [polypeptide binding]; other site 1144275019010 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1144275019011 amphipathic channel; other site 1144275019012 Asn-Pro-Ala signature motifs; other site 1144275019013 MgtC family; Region: MgtC; pfam02308 1144275019014 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1144275019015 Sensory domain found in PocR; Region: PocR; pfam10114 1144275019016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275019017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019018 dimer interface [polypeptide binding]; other site 1144275019019 phosphorylation site [posttranslational modification] 1144275019020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019021 ATP binding site [chemical binding]; other site 1144275019022 Mg2+ binding site [ion binding]; other site 1144275019023 G-X-G motif; other site 1144275019024 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1144275019025 G1 box; other site 1144275019026 GTP/Mg2+ binding site [chemical binding]; other site 1144275019027 G2 box; other site 1144275019028 Switch I region; other site 1144275019029 G3 box; other site 1144275019030 Switch II region; other site 1144275019031 G4 box; other site 1144275019032 G5 box; other site 1144275019033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1144275019034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275019035 Coenzyme A binding pocket [chemical binding]; other site 1144275019036 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1144275019037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019038 Walker A motif; other site 1144275019039 ATP binding site [chemical binding]; other site 1144275019040 Walker B motif; other site 1144275019041 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1144275019042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019043 Walker A motif; other site 1144275019044 ATP binding site [chemical binding]; other site 1144275019045 Walker B motif; other site 1144275019046 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1144275019047 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1144275019048 N-terminal plug; other site 1144275019049 ligand-binding site [chemical binding]; other site 1144275019050 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1144275019051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019052 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1144275019053 active site 1144275019054 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1144275019055 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275019056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275019057 motif II; other site 1144275019058 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1144275019059 putative lipid kinase; Reviewed; Region: PRK13057 1144275019060 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1144275019061 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1144275019062 EamA-like transporter family; Region: EamA; cl01037 1144275019063 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1144275019064 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275019065 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019067 active site 1144275019068 phosphorylation site [posttranslational modification] 1144275019069 intermolecular recognition site; other site 1144275019070 dimerization interface [polypeptide binding]; other site 1144275019071 PAS domain S-box; Region: sensory_box; TIGR00229 1144275019072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019073 putative active site [active] 1144275019074 heme pocket [chemical binding]; other site 1144275019075 PAS domain S-box; Region: sensory_box; TIGR00229 1144275019076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019077 dimer interface [polypeptide binding]; other site 1144275019078 phosphorylation site [posttranslational modification] 1144275019079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019080 ATP binding site [chemical binding]; other site 1144275019081 Mg2+ binding site [ion binding]; other site 1144275019082 G-X-G motif; other site 1144275019083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019090 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019091 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1144275019092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275019098 GAF domain; Region: GAF_2; pfam13185 1144275019099 GAF domain; Region: GAF; cl15785 1144275019100 Domain of unknown function (DUF4200); Region: DUF4200; pfam13863 1144275019101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019102 dimer interface [polypeptide binding]; other site 1144275019103 phosphorylation site [posttranslational modification] 1144275019104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019105 ATP binding site [chemical binding]; other site 1144275019106 Mg2+ binding site [ion binding]; other site 1144275019107 G-X-G motif; other site 1144275019108 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019110 active site 1144275019111 phosphorylation site [posttranslational modification] 1144275019112 intermolecular recognition site; other site 1144275019113 dimerization interface [polypeptide binding]; other site 1144275019114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019115 phosphorylation site [posttranslational modification] 1144275019116 intermolecular recognition site; other site 1144275019117 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019119 active site 1144275019120 phosphorylation site [posttranslational modification] 1144275019121 intermolecular recognition site; other site 1144275019122 dimerization interface [polypeptide binding]; other site 1144275019123 Transglycosylase; Region: Transgly; cl07896 1144275019124 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1144275019125 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1144275019126 DNA binding residues [nucleotide binding] 1144275019127 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1144275019128 GTPase RsgA; Reviewed; Region: PRK01889 1144275019129 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1144275019130 RNA binding site [nucleotide binding]; other site 1144275019131 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1144275019132 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1144275019133 GTP/Mg2+ binding site [chemical binding]; other site 1144275019134 G4 box; other site 1144275019135 G5 box; other site 1144275019136 G1 box; other site 1144275019137 Switch I region; other site 1144275019138 G2 box; other site 1144275019139 G3 box; other site 1144275019140 Switch II region; other site 1144275019141 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275019142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275019143 Helix-turn-helix domains; Region: HTH; cl00088 1144275019144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275019145 classical (c) SDRs; Region: SDR_c; cd05233 1144275019146 NAD(P) binding site [chemical binding]; other site 1144275019147 active site 1144275019148 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1144275019149 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 1144275019150 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1144275019151 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1144275019152 proposed catalytic triad [active] 1144275019153 conserved cys residue [active] 1144275019154 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1144275019155 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1144275019156 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275019157 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1144275019158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019159 Walker A/P-loop; other site 1144275019160 ATP binding site [chemical binding]; other site 1144275019161 Q-loop/lid; other site 1144275019162 ABC transporter signature motif; other site 1144275019163 Walker B; other site 1144275019164 D-loop; other site 1144275019165 H-loop/switch region; other site 1144275019166 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1144275019167 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1144275019168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275019169 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1144275019170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275019171 ligand binding site [chemical binding]; other site 1144275019172 flexible hinge region; other site 1144275019173 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1144275019174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275019175 binding surface 1144275019176 TPR motif; other site 1144275019177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275019178 TPR motif; other site 1144275019179 binding surface 1144275019180 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1144275019181 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1144275019182 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 1144275019183 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1144275019184 Helix-turn-helix domains; Region: HTH; cl00088 1144275019185 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275019186 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275019187 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275019188 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1144275019189 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1144275019190 putative active site [active] 1144275019191 putative active site [active] 1144275019192 catalytic site [active] 1144275019193 catalytic site [active] 1144275019194 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1144275019195 putative active site [active] 1144275019196 catalytic site [active] 1144275019197 Putative zinc-finger; Region: zf-HC2; cl15806 1144275019198 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1144275019199 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1144275019200 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275019201 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275019202 DNA binding residues [nucleotide binding] 1144275019203 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 1144275019204 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1144275019205 Esterase/lipase [General function prediction only]; Region: COG1647 1144275019206 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275019207 PAS fold; Region: PAS_4; pfam08448 1144275019208 GAF domain; Region: GAF_2; pfam13185 1144275019209 GAF domain; Region: GAF; cl15785 1144275019210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019211 dimer interface [polypeptide binding]; other site 1144275019212 phosphorylation site [posttranslational modification] 1144275019213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019214 ATP binding site [chemical binding]; other site 1144275019215 Mg2+ binding site [ion binding]; other site 1144275019216 G-X-G motif; other site 1144275019217 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019219 active site 1144275019220 phosphorylation site [posttranslational modification] 1144275019221 intermolecular recognition site; other site 1144275019222 dimerization interface [polypeptide binding]; other site 1144275019223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275019224 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275019225 Walker A/P-loop; other site 1144275019226 ATP binding site [chemical binding]; other site 1144275019227 Q-loop/lid; other site 1144275019228 ABC transporter signature motif; other site 1144275019229 Walker B; other site 1144275019230 D-loop; other site 1144275019231 H-loop/switch region; other site 1144275019232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275019233 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1144275019234 FtsX-like permease family; Region: FtsX; cl15850 1144275019235 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1144275019236 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275019237 FtsX-like permease family; Region: FtsX; cl15850 1144275019238 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1144275019239 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1144275019240 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 1144275019241 Helix-turn-helix domains; Region: HTH; cl00088 1144275019242 NmrA-like family; Region: NmrA; pfam05368 1144275019243 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1144275019244 NADP binding site [chemical binding]; other site 1144275019245 active site 1144275019246 regulatory binding site [polypeptide binding]; other site 1144275019247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275019248 Helix-turn-helix domains; Region: HTH; cl00088 1144275019249 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1144275019250 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1144275019251 putative NADP binding site [chemical binding]; other site 1144275019252 putative substrate binding site [chemical binding]; other site 1144275019253 active site 1144275019254 glycerol kinase; Provisional; Region: glpK; PRK00047 1144275019255 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1144275019256 N- and C-terminal domain interface [polypeptide binding]; other site 1144275019257 active site 1144275019258 MgATP binding site [chemical binding]; other site 1144275019259 catalytic site [active] 1144275019260 metal binding site [ion binding]; metal-binding site 1144275019261 glycerol binding site [chemical binding]; other site 1144275019262 homotetramer interface [polypeptide binding]; other site 1144275019263 homodimer interface [polypeptide binding]; other site 1144275019264 FBP binding site [chemical binding]; other site 1144275019265 protein IIAGlc interface [polypeptide binding]; other site 1144275019266 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1144275019267 aromatic arch; other site 1144275019268 DCoH dimer interaction site [polypeptide binding]; other site 1144275019269 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1144275019270 DCoH tetramer interaction site [polypeptide binding]; other site 1144275019271 substrate binding site [chemical binding]; other site 1144275019272 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1144275019273 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1144275019274 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275019275 ligand binding site [chemical binding]; other site 1144275019276 flexible hinge region; other site 1144275019277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1144275019278 ligand binding site [chemical binding]; other site 1144275019279 flexible hinge region; other site 1144275019280 BRO family, N-terminal domain; Region: Bro-N; cl10591 1144275019281 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 1144275019282 substrate binding pocket [chemical binding]; other site 1144275019283 substrate-Mg2+ binding site; other site 1144275019284 aspartate-rich region 1; other site 1144275019285 active site lid residues [active] 1144275019286 aspartate-rich region 2; other site 1144275019287 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1144275019288 substrate binding pocket [chemical binding]; other site 1144275019289 substrate-Mg2+ binding site; other site 1144275019290 aspartate-rich region 1; other site 1144275019291 aspartate-rich region 2; other site 1144275019292 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 1144275019293 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1144275019294 metal binding site [ion binding]; metal-binding site 1144275019295 putative dimer interface [polypeptide binding]; other site 1144275019296 Putative zinc-finger; Region: zf-HC2; cl15806 1144275019297 putative anti-sigmaE protein; Provisional; Region: PRK13920 1144275019298 Cupin domain; Region: Cupin_2; cl09118 1144275019299 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1144275019300 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1144275019301 trimer interface [polypeptide binding]; other site 1144275019302 active site 1144275019303 substrate binding site [chemical binding]; other site 1144275019304 CoA binding site [chemical binding]; other site 1144275019305 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1144275019306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275019307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275019308 catalytic residue [active] 1144275019309 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1144275019310 Ligand binding site; other site 1144275019311 Putative Catalytic site; other site 1144275019312 DXD motif; other site 1144275019313 rod shape-determining protein MreB; Provisional; Region: PRK13927 1144275019314 Cell division protein FtsA; Region: FtsA; cl11496 1144275019315 Cytochrome c [Energy production and conversion]; Region: COG3258 1144275019316 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275019317 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275019318 active site 1144275019319 metal binding site [ion binding]; metal-binding site 1144275019320 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1144275019321 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1144275019322 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1144275019323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275019324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275019325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275019326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019327 dimer interface [polypeptide binding]; other site 1144275019328 phosphorylation site [posttranslational modification] 1144275019329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019330 ATP binding site [chemical binding]; other site 1144275019331 Mg2+ binding site [ion binding]; other site 1144275019332 G-X-G motif; other site 1144275019333 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019335 active site 1144275019336 phosphorylation site [posttranslational modification] 1144275019337 intermolecular recognition site; other site 1144275019338 dimerization interface [polypeptide binding]; other site 1144275019339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275019340 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1144275019341 Transglycosylase; Region: Transgly; cl07896 1144275019342 NlpC/P60 family; Region: NLPC_P60; cl11438 1144275019343 Peptidase family M1; Region: Peptidase_M1; pfam01433 1144275019344 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1144275019345 Zn binding site [ion binding]; other site 1144275019346 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 1144275019347 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1144275019348 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1144275019349 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1144275019350 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1144275019351 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1144275019352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019353 Walker A/P-loop; other site 1144275019354 ATP binding site [chemical binding]; other site 1144275019355 Q-loop/lid; other site 1144275019356 ABC transporter signature motif; other site 1144275019357 Walker B; other site 1144275019358 D-loop; other site 1144275019359 H-loop/switch region; other site 1144275019360 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1144275019361 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275019362 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 1144275019363 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1144275019364 Late embryogenesis abundant protein; Region: LEA_2; cl12118 1144275019365 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1144275019366 tetramerization interface [polypeptide binding]; other site 1144275019367 active site 1144275019368 EcsC protein family; Region: EcsC; pfam12787 1144275019369 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1144275019370 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275019371 putative catalytic site [active] 1144275019372 putative metal binding site [ion binding]; other site 1144275019373 putative phosphate binding site [ion binding]; other site 1144275019374 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1144275019375 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275019376 putative active site [active] 1144275019377 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275019378 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1144275019379 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275019380 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1144275019381 catalytic residues [active] 1144275019382 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1144275019383 NAD synthetase; Provisional; Region: PRK13981 1144275019384 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1144275019385 multimer interface [polypeptide binding]; other site 1144275019386 active site 1144275019387 catalytic triad [active] 1144275019388 protein interface 1 [polypeptide binding]; other site 1144275019389 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1144275019390 homodimer interface [polypeptide binding]; other site 1144275019391 NAD binding pocket [chemical binding]; other site 1144275019392 ATP binding pocket [chemical binding]; other site 1144275019393 Mg binding site [ion binding]; other site 1144275019394 active-site loop [active] 1144275019395 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1144275019396 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275019397 PAS domain; Region: PAS_9; pfam13426 1144275019398 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275019399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019400 phosphorylation site [posttranslational modification] 1144275019401 dimer interface [polypeptide binding]; other site 1144275019402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019403 ATP binding site [chemical binding]; other site 1144275019404 G-X-G motif; other site 1144275019405 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019407 active site 1144275019408 phosphorylation site [posttranslational modification] 1144275019409 intermolecular recognition site; other site 1144275019410 dimerization interface [polypeptide binding]; other site 1144275019411 TM2 domain; Region: TM2; cl00984 1144275019412 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1144275019413 DNA-binding site [nucleotide binding]; DNA binding site 1144275019414 RNA-binding motif; other site 1144275019415 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1144275019416 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1144275019417 putative di-iron ligands [ion binding]; other site 1144275019418 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1144275019419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275019420 motif II; other site 1144275019421 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275019422 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275019423 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275019424 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 1144275019425 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275019426 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1144275019427 GAF domain; Region: GAF; cl15785 1144275019428 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275019429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019430 putative active site [active] 1144275019431 heme pocket [chemical binding]; other site 1144275019432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019433 dimer interface [polypeptide binding]; other site 1144275019434 phosphorylation site [posttranslational modification] 1144275019435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019436 ATP binding site [chemical binding]; other site 1144275019437 Mg2+ binding site [ion binding]; other site 1144275019438 G-X-G motif; other site 1144275019439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019440 PAS domain; Region: PAS_9; pfam13426 1144275019441 putative active site [active] 1144275019442 heme pocket [chemical binding]; other site 1144275019443 PAS domain S-box; Region: sensory_box; TIGR00229 1144275019444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019445 putative active site [active] 1144275019446 heme pocket [chemical binding]; other site 1144275019447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019448 dimer interface [polypeptide binding]; other site 1144275019449 phosphorylation site [posttranslational modification] 1144275019450 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1144275019451 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1144275019452 GSH binding site [chemical binding]; other site 1144275019453 catalytic residues [active] 1144275019454 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1144275019455 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1144275019456 Peptidase family U32; Region: Peptidase_U32; cl03113 1144275019457 Collagenase; Region: DUF3656; pfam12392 1144275019458 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1144275019459 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1144275019460 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1144275019461 active site 1144275019462 pteridine reductase; Provisional; Region: PRK09135 1144275019463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275019464 NAD(P) binding site [chemical binding]; other site 1144275019465 active site 1144275019466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275019467 S-adenosylmethionine binding site [chemical binding]; other site 1144275019468 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275019469 PilZ domain; Region: PilZ; cl01260 1144275019470 Pollen proteins Ole e I like; Region: Pollen_Ole_e_I; pfam01190 1144275019471 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1144275019472 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1144275019473 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275019474 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 1144275019475 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1144275019476 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1144275019477 catalytic residue [active] 1144275019478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275019479 DNA binding residues [nucleotide binding] 1144275019480 dimerization interface [polypeptide binding]; other site 1144275019481 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275019482 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275019483 active site 1144275019484 metal binding site [ion binding]; metal-binding site 1144275019485 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1144275019486 catalytic residues [active] 1144275019487 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019488 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275019489 ligand binding site [chemical binding]; other site 1144275019490 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1144275019491 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275019492 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275019493 active site 1144275019494 ATP binding site [chemical binding]; other site 1144275019495 substrate binding site [chemical binding]; other site 1144275019496 activation loop (A-loop); other site 1144275019497 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1144275019498 cyclase homology domain; Region: CHD; cd07302 1144275019499 nucleotidyl binding site; other site 1144275019500 dimer interface [polypeptide binding]; other site 1144275019501 Predicted ATPase [General function prediction only]; Region: COG3899 1144275019502 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019503 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1144275019504 Protein of unknown function, DUF393; Region: DUF393; cl01136 1144275019505 Lipase maturation factor; Region: LMF1; pfam06762 1144275019506 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1144275019507 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1144275019508 Amidinotransferase; Region: Amidinotransf; cl12043 1144275019509 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1144275019510 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1144275019511 Receptor L domain; Region: Recep_L_domain; pfam01030 1144275019512 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1144275019513 putative hydrophobic ligand binding site [chemical binding]; other site 1144275019514 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275019515 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1144275019516 circadian clock protein KaiC; Reviewed; Region: PRK09302 1144275019517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019518 Walker A motif; other site 1144275019519 ATP binding site [chemical binding]; other site 1144275019520 Walker B motif; other site 1144275019521 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019522 Walker A motif; other site 1144275019523 ATP binding site [chemical binding]; other site 1144275019524 Walker B motif; other site 1144275019525 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019527 active site 1144275019528 phosphorylation site [posttranslational modification] 1144275019529 intermolecular recognition site; other site 1144275019530 dimerization interface [polypeptide binding]; other site 1144275019531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019533 G1 box; other site 1144275019534 G1 box; other site 1144275019535 GTP/Mg2+ binding site [chemical binding]; other site 1144275019536 GTP/Mg2+ binding site [chemical binding]; other site 1144275019537 G2 box; other site 1144275019538 Switch I region; other site 1144275019539 G3 box; other site 1144275019540 Switch II region; other site 1144275019541 G4 box; other site 1144275019542 G5 box; other site 1144275019543 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275019544 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1144275019545 Helix-turn-helix domains; Region: HTH; cl00088 1144275019546 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1144275019547 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275019548 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1144275019549 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1144275019550 active site 1144275019551 dimer interface [polypeptide binding]; other site 1144275019552 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1144275019553 dimer interface [polypeptide binding]; other site 1144275019554 active site 1144275019555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275019556 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1144275019557 classical (c) SDRs; Region: SDR_c; cd05233 1144275019558 NAD(P) binding site [chemical binding]; other site 1144275019559 active site 1144275019560 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1144275019561 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1144275019562 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1144275019563 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 1144275019564 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1144275019565 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 1144275019566 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1144275019567 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1144275019568 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1144275019569 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1144275019570 alpha subunit interaction interface [polypeptide binding]; other site 1144275019571 Walker A motif; other site 1144275019572 ATP binding site [chemical binding]; other site 1144275019573 Walker B motif; other site 1144275019574 inhibitor binding site; inhibition site 1144275019575 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1144275019576 ATP synthase; Region: ATP-synt; cl00365 1144275019577 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1144275019578 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1144275019579 putative active site [active] 1144275019580 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1144275019581 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1144275019582 catalytic residues [active] 1144275019583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1144275019584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019585 Walker A/P-loop; other site 1144275019586 ATP binding site [chemical binding]; other site 1144275019587 Q-loop/lid; other site 1144275019588 ABC transporter signature motif; other site 1144275019589 Walker B; other site 1144275019590 D-loop; other site 1144275019591 H-loop/switch region; other site 1144275019592 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1144275019593 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275019594 Ligand Binding Site [chemical binding]; other site 1144275019595 CsbD-like; Region: CsbD; cl15799 1144275019596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275019597 dimer interface [polypeptide binding]; other site 1144275019598 putative CheW interface [polypeptide binding]; other site 1144275019599 Predicted ATPases [General function prediction only]; Region: COG1106 1144275019600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019601 Walker A/P-loop; other site 1144275019602 ATP binding site [chemical binding]; other site 1144275019603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019604 Walker B; other site 1144275019605 D-loop; other site 1144275019606 H-loop/switch region; other site 1144275019607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275019608 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1144275019609 active site 1144275019610 metal binding site [ion binding]; metal-binding site 1144275019611 phytoene desaturase; Region: crtI_fam; TIGR02734 1144275019612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275019613 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275019614 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1144275019615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275019616 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275019617 CHASE3 domain; Region: CHASE3; cl05000 1144275019618 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1144275019619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275019620 dimerization interface [polypeptide binding]; other site 1144275019621 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275019622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275019623 dimer interface [polypeptide binding]; other site 1144275019624 putative CheW interface [polypeptide binding]; other site 1144275019625 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275019626 putative binding surface; other site 1144275019627 active site 1144275019628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019629 ATP binding site [chemical binding]; other site 1144275019630 Mg2+ binding site [ion binding]; other site 1144275019631 G-X-G motif; other site 1144275019632 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275019633 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019635 active site 1144275019636 phosphorylation site [posttranslational modification] 1144275019637 intermolecular recognition site; other site 1144275019638 dimerization interface [polypeptide binding]; other site 1144275019639 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1144275019640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019641 active site 1144275019642 phosphorylation site [posttranslational modification] 1144275019643 intermolecular recognition site; other site 1144275019644 dimerization interface [polypeptide binding]; other site 1144275019645 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275019646 GAF domain; Region: GAF; cl15785 1144275019647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019648 dimer interface [polypeptide binding]; other site 1144275019649 phosphorylation site [posttranslational modification] 1144275019650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019651 ATP binding site [chemical binding]; other site 1144275019652 Mg2+ binding site [ion binding]; other site 1144275019653 G-X-G motif; other site 1144275019654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275019655 Helix-turn-helix domains; Region: HTH; cl00088 1144275019656 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1144275019657 putative effector binding pocket; other site 1144275019658 putative dimerization interface [polypeptide binding]; other site 1144275019659 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1144275019660 classical (c) SDRs; Region: SDR_c; cd05233 1144275019661 NAD(P) binding site [chemical binding]; other site 1144275019662 active site 1144275019663 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1144275019664 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1144275019665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275019666 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1144275019667 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1144275019668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019669 active site 1144275019670 phosphorylation site [posttranslational modification] 1144275019671 intermolecular recognition site; other site 1144275019672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275019673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275019674 dimerization interface [polypeptide binding]; other site 1144275019675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019676 dimer interface [polypeptide binding]; other site 1144275019677 phosphorylation site [posttranslational modification] 1144275019678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019679 ATP binding site [chemical binding]; other site 1144275019680 Mg2+ binding site [ion binding]; other site 1144275019681 G-X-G motif; other site 1144275019682 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275019683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019684 active site 1144275019685 phosphorylation site [posttranslational modification] 1144275019686 intermolecular recognition site; other site 1144275019687 dimerization interface [polypeptide binding]; other site 1144275019688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275019689 Walker A motif; other site 1144275019690 ATP binding site [chemical binding]; other site 1144275019691 Walker B motif; other site 1144275019692 arginine finger; other site 1144275019693 Helix-turn-helix domains; Region: HTH; cl00088 1144275019694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275019695 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275019696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019697 putative active site [active] 1144275019698 heme pocket [chemical binding]; other site 1144275019699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019700 dimer interface [polypeptide binding]; other site 1144275019701 phosphorylation site [posttranslational modification] 1144275019702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019703 ATP binding site [chemical binding]; other site 1144275019704 Mg2+ binding site [ion binding]; other site 1144275019705 G-X-G motif; other site 1144275019706 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1144275019707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019708 active site 1144275019709 phosphorylation site [posttranslational modification] 1144275019710 intermolecular recognition site; other site 1144275019711 dimerization interface [polypeptide binding]; other site 1144275019712 CheB methylesterase; Region: CheB_methylest; pfam01339 1144275019713 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1144275019714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275019715 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1144275019716 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1144275019717 HEAT repeats; Region: HEAT_2; pfam13646 1144275019718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275019719 putative CheW interface [polypeptide binding]; other site 1144275019720 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275019721 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275019722 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1144275019723 putative binding surface; other site 1144275019724 active site 1144275019725 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1144275019726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019727 ATP binding site [chemical binding]; other site 1144275019728 Mg2+ binding site [ion binding]; other site 1144275019729 G-X-G motif; other site 1144275019730 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1144275019731 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019733 active site 1144275019734 phosphorylation site [posttranslational modification] 1144275019735 intermolecular recognition site; other site 1144275019736 dimerization interface [polypeptide binding]; other site 1144275019737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019738 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019739 active site 1144275019740 phosphorylation site [posttranslational modification] 1144275019741 intermolecular recognition site; other site 1144275019742 dimerization interface [polypeptide binding]; other site 1144275019743 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275019744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275019745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019746 dimer interface [polypeptide binding]; other site 1144275019747 phosphorylation site [posttranslational modification] 1144275019748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019749 ATP binding site [chemical binding]; other site 1144275019750 Mg2+ binding site [ion binding]; other site 1144275019751 G-X-G motif; other site 1144275019752 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019754 active site 1144275019755 phosphorylation site [posttranslational modification] 1144275019756 intermolecular recognition site; other site 1144275019757 dimerization interface [polypeptide binding]; other site 1144275019758 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019760 active site 1144275019761 phosphorylation site [posttranslational modification] 1144275019762 intermolecular recognition site; other site 1144275019763 dimerization interface [polypeptide binding]; other site 1144275019764 GAF domain; Region: GAF; cl15785 1144275019765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019766 PAS fold; Region: PAS_3; pfam08447 1144275019767 putative active site [active] 1144275019768 heme pocket [chemical binding]; other site 1144275019769 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1144275019770 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275019771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019772 dimer interface [polypeptide binding]; other site 1144275019773 phosphorylation site [posttranslational modification] 1144275019774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019775 ATP binding site [chemical binding]; other site 1144275019776 Mg2+ binding site [ion binding]; other site 1144275019777 G-X-G motif; other site 1144275019778 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275019779 active site 1144275019780 ATP binding site [chemical binding]; other site 1144275019781 substrate binding site [chemical binding]; other site 1144275019782 activation loop (A-loop); other site 1144275019783 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275019784 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275019785 active site 1144275019786 ATP binding site [chemical binding]; other site 1144275019787 substrate binding site [chemical binding]; other site 1144275019788 activation loop (A-loop); other site 1144275019789 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275019790 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275019791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275019792 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275019793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019794 active site 1144275019795 phosphorylation site [posttranslational modification] 1144275019796 intermolecular recognition site; other site 1144275019797 dimerization interface [polypeptide binding]; other site 1144275019798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019799 PAS fold; Region: PAS_3; pfam08447 1144275019800 putative active site [active] 1144275019801 heme pocket [chemical binding]; other site 1144275019802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275019803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019804 ATP binding site [chemical binding]; other site 1144275019805 G-X-G motif; other site 1144275019806 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019808 active site 1144275019809 phosphorylation site [posttranslational modification] 1144275019810 intermolecular recognition site; other site 1144275019811 dimerization interface [polypeptide binding]; other site 1144275019812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275019813 PAS fold; Region: PAS_3; pfam08447 1144275019814 putative active site [active] 1144275019815 heme pocket [chemical binding]; other site 1144275019816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019817 dimer interface [polypeptide binding]; other site 1144275019818 phosphorylation site [posttranslational modification] 1144275019819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019820 ATP binding site [chemical binding]; other site 1144275019821 Mg2+ binding site [ion binding]; other site 1144275019822 G-X-G motif; other site 1144275019823 Helix-turn-helix domains; Region: HTH; cl00088 1144275019824 metal binding site 2 [ion binding]; metal-binding site 1144275019825 putative DNA binding helix; other site 1144275019826 metal binding site 1 [ion binding]; metal-binding site 1144275019827 structural Zn2+ binding site [ion binding]; other site 1144275019828 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275019829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019830 active site 1144275019831 phosphorylation site [posttranslational modification] 1144275019832 intermolecular recognition site; other site 1144275019833 dimerization interface [polypeptide binding]; other site 1144275019834 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1144275019835 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1144275019836 putative active site [active] 1144275019837 putative metal binding site [ion binding]; other site 1144275019838 DoxX; Region: DoxX; cl00976 1144275019839 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1144275019840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275019841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019842 ATP binding site [chemical binding]; other site 1144275019843 Mg2+ binding site [ion binding]; other site 1144275019844 G-X-G motif; other site 1144275019845 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1144275019846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275019847 active site 1144275019848 phosphorylation site [posttranslational modification] 1144275019849 intermolecular recognition site; other site 1144275019850 dimerization interface [polypeptide binding]; other site 1144275019851 Helix-turn-helix domains; Region: HTH; cl00088 1144275019852 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275019853 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275019854 Immunity protein Imm5; Region: Imm5; pfam14423 1144275019855 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1144275019856 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1144275019857 ATP synthase; Region: ATP-synt; cl00365 1144275019858 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1144275019859 RHS Repeat; Region: RHS_repeat; cl11982 1144275019860 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1144275019861 RHS Repeat; Region: RHS_repeat; cl11982 1144275019862 RHS Repeat; Region: RHS_repeat; cl11982 1144275019863 RHS Repeat; Region: RHS_repeat; cl11982 1144275019864 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1144275019865 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1144275019866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275019867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275019868 dimerization interface [polypeptide binding]; other site 1144275019869 putative DNA binding site [nucleotide binding]; other site 1144275019870 putative Zn2+ binding site [ion binding]; other site 1144275019871 GLTT repeat (6 copies); Region: GLTT; pfam01744 1144275019872 PAS fold; Region: PAS_3; pfam08447 1144275019873 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275019874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019875 dimer interface [polypeptide binding]; other site 1144275019876 phosphorylation site [posttranslational modification] 1144275019877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019878 ATP binding site [chemical binding]; other site 1144275019879 Mg2+ binding site [ion binding]; other site 1144275019880 G-X-G motif; other site 1144275019881 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275019882 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275019883 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275019884 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275019885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275019886 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 1144275019887 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1144275019888 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1144275019889 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1144275019890 putative active site [active] 1144275019891 putative metal binding site [ion binding]; other site 1144275019892 Cupin domain; Region: Cupin_2; cl09118 1144275019893 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1144275019894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275019895 S-adenosylmethionine binding site [chemical binding]; other site 1144275019896 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1144275019897 Citrate synthase; Region: Citrate_synt; pfam00285 1144275019898 dimer interface [polypeptide binding]; other site 1144275019899 active site 1144275019900 oxalacetate/citrate binding site [chemical binding]; other site 1144275019901 citrylCoA binding site [chemical binding]; other site 1144275019902 coenzyme A binding site [chemical binding]; other site 1144275019903 catalytic triad [active] 1144275019904 GTP-binding protein YchF; Reviewed; Region: PRK09601 1144275019905 YchF GTPase; Region: YchF; cd01900 1144275019906 G1 box; other site 1144275019907 GTP/Mg2+ binding site [chemical binding]; other site 1144275019908 Switch I region; other site 1144275019909 G2 box; other site 1144275019910 Switch II region; other site 1144275019911 G3 box; other site 1144275019912 G4 box; other site 1144275019913 G5 box; other site 1144275019914 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1144275019915 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1144275019916 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1144275019917 ATP synthase A chain; Region: ATP-synt_A; cl00413 1144275019918 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1144275019919 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1144275019920 substrate binding site [chemical binding]; other site 1144275019921 Protein of unknown function (DUF692); Region: DUF692; cl01263 1144275019922 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1144275019923 hypothetical protein; Provisional; Region: PRK08317 1144275019924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275019925 S-adenosylmethionine binding site [chemical binding]; other site 1144275019926 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 1144275019927 putative ligand binding site [chemical binding]; other site 1144275019928 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1144275019929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275019930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275019931 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1144275019932 PAS fold; Region: PAS; pfam00989 1144275019933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275019934 GAF domain; Region: GAF; cl15785 1144275019935 GAF domain; Region: GAF; cl15785 1144275019936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275019937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275019938 dimer interface [polypeptide binding]; other site 1144275019939 phosphorylation site [posttranslational modification] 1144275019940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275019941 ATP binding site [chemical binding]; other site 1144275019942 Mg2+ binding site [ion binding]; other site 1144275019943 G-X-G motif; other site 1144275019944 Protein kinase domain; Region: Pkinase; pfam00069 1144275019945 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275019946 active site 1144275019947 ATP binding site [chemical binding]; other site 1144275019948 substrate binding site [chemical binding]; other site 1144275019949 activation loop (A-loop); other site 1144275019950 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1144275019951 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1144275019952 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1144275019953 inhibitor-cofactor binding pocket; inhibition site 1144275019954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275019955 catalytic residue [active] 1144275019956 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 1144275019957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275019958 Walker A/P-loop; other site 1144275019959 ATP binding site [chemical binding]; other site 1144275019960 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1144275019961 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275019962 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1144275019963 dimer interface [polypeptide binding]; other site 1144275019964 active site 1144275019965 metal binding site [ion binding]; metal-binding site 1144275019966 glutathione binding site [chemical binding]; other site 1144275019967 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1144275019968 MgtE intracellular N domain; Region: MgtE_N; cl15244 1144275019969 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1144275019970 Divalent cation transporter; Region: MgtE; cl00786 1144275019971 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1144275019972 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1144275019973 putative NAD(P) binding site [chemical binding]; other site 1144275019974 homodimer interface [polypeptide binding]; other site 1144275019975 homotetramer interface [polypeptide binding]; other site 1144275019976 active site 1144275019977 TPR repeat; Region: TPR_11; pfam13414 1144275019978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1144275019979 short chain dehydrogenase; Provisional; Region: PRK05650 1144275019980 classical (c) SDRs; Region: SDR_c; cd05233 1144275019981 NAD(P) binding site [chemical binding]; other site 1144275019982 active site 1144275019983 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 1144275019984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1144275019985 active site 1144275019986 motif I; other site 1144275019987 motif II; other site 1144275019988 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1144275019989 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1144275019990 lipoprotein signal peptidase; Provisional; Region: PRK14787 1144275019991 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1144275019992 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1144275019993 putative catalytic site [active] 1144275019994 putative metal binding site [ion binding]; other site 1144275019995 putative phosphate binding site [ion binding]; other site 1144275019996 Ubiquitin-like proteins; Region: UBQ; cl00155 1144275019997 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 1144275019998 Protein of unknown function DUF82; Region: DUF82; pfam01927 1144275019999 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1144275020000 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1144275020001 active site 1144275020002 HIGH motif; other site 1144275020003 nucleotide binding site [chemical binding]; other site 1144275020004 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1144275020005 active site 1144275020006 KMSKS motif; other site 1144275020007 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1144275020008 tRNA binding surface [nucleotide binding]; other site 1144275020009 anticodon binding site; other site 1144275020010 TadE-like protein; Region: TadE; cl10688 1144275020011 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1144275020012 phosphopeptide binding site; other site 1144275020013 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1144275020014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275020015 Walker A motif; other site 1144275020016 ATP binding site [chemical binding]; other site 1144275020017 Walker B motif; other site 1144275020018 arginine finger; other site 1144275020019 Helix-turn-helix domains; Region: HTH; cl00088 1144275020020 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1144275020021 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1144275020022 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1144275020023 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1144275020024 catalytic residues [active] 1144275020025 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020026 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275020027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275020028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020029 dimer interface [polypeptide binding]; other site 1144275020030 phosphorylation site [posttranslational modification] 1144275020031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020032 ATP binding site [chemical binding]; other site 1144275020033 Mg2+ binding site [ion binding]; other site 1144275020034 G-X-G motif; other site 1144275020035 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1144275020036 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275020037 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275020038 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275020039 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1144275020040 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1144275020041 amidase catalytic site [active] 1144275020042 Zn binding residues [ion binding]; other site 1144275020043 substrate binding site [chemical binding]; other site 1144275020044 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1144275020045 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 1144275020046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275020047 putative active site [active] 1144275020048 putative metal binding site [ion binding]; other site 1144275020049 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275020050 K+ potassium transporter; Region: K_trans; cl15781 1144275020051 GAF domain; Region: GAF; cl15785 1144275020052 GAF domain; Region: GAF; cl15785 1144275020053 GAF domain; Region: GAF_2; pfam13185 1144275020054 PAS domain S-box; Region: sensory_box; TIGR00229 1144275020055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275020056 putative active site [active] 1144275020057 heme pocket [chemical binding]; other site 1144275020058 GAF domain; Region: GAF; cl15785 1144275020059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020060 dimer interface [polypeptide binding]; other site 1144275020061 phosphorylation site [posttranslational modification] 1144275020062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020063 ATP binding site [chemical binding]; other site 1144275020064 Mg2+ binding site [ion binding]; other site 1144275020065 G-X-G motif; other site 1144275020066 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1144275020067 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020068 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1144275020069 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1144275020070 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275020071 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1144275020072 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1144275020073 Zn binding site [ion binding]; other site 1144275020074 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1144275020075 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 1144275020076 Walker A/P-loop; other site 1144275020077 ATP binding site [chemical binding]; other site 1144275020078 Q-loop/lid; other site 1144275020079 ABC transporter signature motif; other site 1144275020080 Walker B; other site 1144275020081 D-loop; other site 1144275020082 H-loop/switch region; other site 1144275020083 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1144275020084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1144275020085 DNA-binding site [nucleotide binding]; DNA binding site 1144275020086 OpgC protein; Region: OpgC_C; cl00792 1144275020087 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020089 active site 1144275020090 phosphorylation site [posttranslational modification] 1144275020091 intermolecular recognition site; other site 1144275020092 dimerization interface [polypeptide binding]; other site 1144275020093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020094 dimer interface [polypeptide binding]; other site 1144275020095 phosphorylation site [posttranslational modification] 1144275020096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020097 ATP binding site [chemical binding]; other site 1144275020098 Mg2+ binding site [ion binding]; other site 1144275020099 G-X-G motif; other site 1144275020100 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020102 active site 1144275020103 phosphorylation site [posttranslational modification] 1144275020104 intermolecular recognition site; other site 1144275020105 dimerization interface [polypeptide binding]; other site 1144275020106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275020107 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1144275020108 Helix-turn-helix domain; Region: HTH_18; pfam12833 1144275020109 Carbon starvation protein CstA; Region: CstA; pfam02554 1144275020110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275020111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275020112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020113 dimer interface [polypeptide binding]; other site 1144275020114 phosphorylation site [posttranslational modification] 1144275020115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020116 ATP binding site [chemical binding]; other site 1144275020117 Mg2+ binding site [ion binding]; other site 1144275020118 G-X-G motif; other site 1144275020119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275020120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1144275020121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020122 dimer interface [polypeptide binding]; other site 1144275020123 phosphorylation site [posttranslational modification] 1144275020124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020125 ATP binding site [chemical binding]; other site 1144275020126 Mg2+ binding site [ion binding]; other site 1144275020127 G-X-G motif; other site 1144275020128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020129 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1144275020130 UreF; Region: UreF; pfam01730 1144275020131 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1144275020132 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1144275020133 subunit interactions [polypeptide binding]; other site 1144275020134 active site 1144275020135 flap region; other site 1144275020136 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 1144275020137 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1144275020138 alpha-gamma subunit interface [polypeptide binding]; other site 1144275020139 beta-gamma subunit interface [polypeptide binding]; other site 1144275020140 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1144275020141 alpha-beta subunit interface [polypeptide binding]; other site 1144275020142 UreD urease accessory protein; Region: UreD; cl00530 1144275020143 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1144275020144 Putative esterase; Region: Esterase; pfam00756 1144275020145 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275020147 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275020148 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275020149 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 1144275020150 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1144275020151 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1144275020152 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275020153 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275020154 active site 1144275020155 catalytic tetrad [active] 1144275020156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275020157 Helix-turn-helix domains; Region: HTH; cl00088 1144275020158 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1144275020159 Amidase; Region: Amidase; cl11426 1144275020160 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275020161 Predicted membrane protein [Function unknown]; Region: COG3918 1144275020162 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1144275020163 apolar tunnel; other site 1144275020164 heme binding site [chemical binding]; other site 1144275020165 dimerization interface [polypeptide binding]; other site 1144275020166 5'-3' exonuclease; Region: 53EXOc; smart00475 1144275020167 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1144275020168 active site 1144275020169 metal binding site 1 [ion binding]; metal-binding site 1144275020170 putative 5' ssDNA interaction site; other site 1144275020171 metal binding site 3; metal-binding site 1144275020172 metal binding site 2 [ion binding]; metal-binding site 1144275020173 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1144275020174 putative DNA binding site [nucleotide binding]; other site 1144275020175 putative metal binding site [ion binding]; other site 1144275020176 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1144275020177 ligand binding site [chemical binding]; other site 1144275020178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275020179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020180 ATP binding site [chemical binding]; other site 1144275020181 Mg2+ binding site [ion binding]; other site 1144275020182 G-X-G motif; other site 1144275020183 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020185 active site 1144275020186 phosphorylation site [posttranslational modification] 1144275020187 intermolecular recognition site; other site 1144275020188 dimerization interface [polypeptide binding]; other site 1144275020189 Restriction endonuclease; Region: Mrr_cat; cl00516 1144275020190 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275020191 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1144275020192 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020193 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1144275020194 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1144275020195 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1144275020196 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1144275020197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020198 dimer interface [polypeptide binding]; other site 1144275020199 phosphorylation site [posttranslational modification] 1144275020200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020201 ATP binding site [chemical binding]; other site 1144275020202 Mg2+ binding site [ion binding]; other site 1144275020203 G-X-G motif; other site 1144275020204 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020206 active site 1144275020207 phosphorylation site [posttranslational modification] 1144275020208 intermolecular recognition site; other site 1144275020209 dimerization interface [polypeptide binding]; other site 1144275020210 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1144275020211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020212 dimer interface [polypeptide binding]; other site 1144275020213 phosphorylation site [posttranslational modification] 1144275020214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020215 ATP binding site [chemical binding]; other site 1144275020216 Mg2+ binding site [ion binding]; other site 1144275020217 G-X-G motif; other site 1144275020218 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1144275020219 FAD binding domain; Region: FAD_binding_4; pfam01565 1144275020220 Berberine and berberine like; Region: BBE; pfam08031 1144275020221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1144275020222 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1144275020223 inhibitor-cofactor binding pocket; inhibition site 1144275020224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275020225 catalytic residue [active] 1144275020226 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1144275020227 Di-iron ligands [ion binding]; other site 1144275020228 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1144275020229 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1144275020230 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1144275020231 NADP binding site [chemical binding]; other site 1144275020232 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275020233 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1144275020234 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1144275020235 NADP binding site [chemical binding]; other site 1144275020236 Helix-turn-helix domains; Region: HTH; cl00088 1144275020237 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275020238 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1144275020239 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1144275020240 PAS fold; Region: PAS_4; pfam08448 1144275020241 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275020242 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275020243 putative active site [active] 1144275020244 heme pocket [chemical binding]; other site 1144275020245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020246 dimer interface [polypeptide binding]; other site 1144275020247 phosphorylation site [posttranslational modification] 1144275020248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020249 ATP binding site [chemical binding]; other site 1144275020250 Mg2+ binding site [ion binding]; other site 1144275020251 G-X-G motif; other site 1144275020252 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020254 active site 1144275020255 phosphorylation site [posttranslational modification] 1144275020256 intermolecular recognition site; other site 1144275020257 dimerization interface [polypeptide binding]; other site 1144275020258 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1144275020259 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1144275020260 active site 1144275020261 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1144275020262 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1144275020263 protein binding site [polypeptide binding]; other site 1144275020264 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1144275020265 Active site serine [active] 1144275020266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1144275020267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1144275020268 DNA binding residues [nucleotide binding] 1144275020269 dimerization interface [polypeptide binding]; other site 1144275020270 Fic/DOC family; Region: Fic; cl00960 1144275020271 MoxR-like ATPases [General function prediction only]; Region: COG0714 1144275020272 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020273 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1144275020274 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275020275 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275020276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275020277 active site 1144275020278 catalytic tetrad [active] 1144275020279 PAS domain; Region: PAS_9; pfam13426 1144275020280 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275020281 GAF domain; Region: GAF; cl15785 1144275020282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020283 dimer interface [polypeptide binding]; other site 1144275020284 phosphorylation site [posttranslational modification] 1144275020285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020286 ATP binding site [chemical binding]; other site 1144275020287 Mg2+ binding site [ion binding]; other site 1144275020288 G-X-G motif; other site 1144275020289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1144275020290 FeS/SAM binding site; other site 1144275020291 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1144275020292 active site 1144275020293 catalytic residues [active] 1144275020294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275020295 ATP binding site [chemical binding]; other site 1144275020296 putative Mg++ binding site [ion binding]; other site 1144275020297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275020298 nucleotide binding region [chemical binding]; other site 1144275020299 ATP-binding site [chemical binding]; other site 1144275020300 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1144275020301 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1144275020302 Ligand Binding Site [chemical binding]; other site 1144275020303 Molecular Tunnel; other site 1144275020304 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1144275020305 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1144275020306 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1144275020307 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1144275020308 active site 1144275020309 TDP-binding site; other site 1144275020310 acceptor substrate-binding pocket; other site 1144275020311 homodimer interface [polypeptide binding]; other site 1144275020312 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1144275020313 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1144275020314 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1144275020315 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275020316 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275020317 protein binding site [polypeptide binding]; other site 1144275020318 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1144275020319 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1144275020320 protein binding site [polypeptide binding]; other site 1144275020321 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 1144275020322 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1144275020323 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1144275020324 putative catalytic residue [active] 1144275020325 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1144275020326 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1144275020327 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1144275020328 DsbD alpha interface [polypeptide binding]; other site 1144275020329 catalytic residues [active] 1144275020330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275020331 metal ion-dependent adhesion site (MIDAS); other site 1144275020332 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1144275020333 Cysteine-rich domain; Region: CCG; pfam02754 1144275020334 Cysteine-rich domain; Region: CCG; pfam02754 1144275020335 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1144275020336 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1144275020337 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1144275020338 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1144275020339 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1144275020340 translocation protein TolB; Provisional; Region: tolB; PRK04922 1144275020341 Peptidase family M54; Region: Peptidase_M54; cl00835 1144275020342 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 1144275020343 Ribosome-binding factor A; Region: RBFA; cl00542 1144275020344 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1144275020345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1144275020346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1144275020347 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1144275020348 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1144275020349 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275020350 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1144275020351 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020352 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1144275020353 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275020354 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155 1144275020355 acyl-CoA synthetase; Validated; Region: PRK08308 1144275020356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1144275020357 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1144275020358 active site 1144275020359 metal binding site [ion binding]; metal-binding site 1144275020360 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1144275020361 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275020362 active site 1144275020363 ATP binding site [chemical binding]; other site 1144275020364 substrate binding site [chemical binding]; other site 1144275020365 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275020366 substrate binding site [chemical binding]; other site 1144275020367 activation loop (A-loop); other site 1144275020368 activation loop (A-loop); other site 1144275020369 DNA translocase FtsK; Provisional; Region: PRK10263 1144275020370 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020371 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1144275020372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020373 ATP binding site [chemical binding]; other site 1144275020374 Mg2+ binding site [ion binding]; other site 1144275020375 G-X-G motif; other site 1144275020376 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1144275020377 anchoring element; other site 1144275020378 dimer interface [polypeptide binding]; other site 1144275020379 ATP binding site [chemical binding]; other site 1144275020380 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1144275020381 active site 1144275020382 putative metal-binding site [ion binding]; other site 1144275020383 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1144275020384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275020385 Coenzyme A binding pocket [chemical binding]; other site 1144275020386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275020387 non-specific DNA binding site [nucleotide binding]; other site 1144275020388 salt bridge; other site 1144275020389 sequence-specific DNA binding site [nucleotide binding]; other site 1144275020390 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1144275020391 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1144275020392 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1144275020393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275020394 Ligand Binding Site [chemical binding]; other site 1144275020395 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020397 active site 1144275020398 phosphorylation site [posttranslational modification] 1144275020399 intermolecular recognition site; other site 1144275020400 dimerization interface [polypeptide binding]; other site 1144275020401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020402 active site 1144275020403 phosphorylation site [posttranslational modification] 1144275020404 intermolecular recognition site; other site 1144275020405 dimerization interface [polypeptide binding]; other site 1144275020406 GAF domain; Region: GAF_2; pfam13185 1144275020407 GAF domain; Region: GAF; cl15785 1144275020408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275020409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020410 ATP binding site [chemical binding]; other site 1144275020411 Mg2+ binding site [ion binding]; other site 1144275020412 G-X-G motif; other site 1144275020413 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275020414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1144275020415 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1144275020416 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1144275020417 catalytic residue [active] 1144275020418 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1144275020419 active site 1144275020420 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1144275020421 active site 1144275020422 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1144275020423 mce related protein; Region: MCE; pfam02470 1144275020424 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1144275020425 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 1144275020426 Walker A/P-loop; other site 1144275020427 ATP binding site [chemical binding]; other site 1144275020428 Q-loop/lid; other site 1144275020429 ABC transporter signature motif; other site 1144275020430 Walker B; other site 1144275020431 D-loop; other site 1144275020432 H-loop/switch region; other site 1144275020433 Permease; Region: Permease; cl00510 1144275020434 recombination protein F; Reviewed; Region: recF; PRK00064 1144275020435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020436 Walker A/P-loop; other site 1144275020437 ATP binding site [chemical binding]; other site 1144275020438 Q-loop/lid; other site 1144275020439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020440 ABC transporter signature motif; other site 1144275020441 Walker B; other site 1144275020442 D-loop; other site 1144275020443 H-loop/switch region; other site 1144275020444 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1144275020445 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1144275020446 active site 1144275020447 putative substrate binding region [chemical binding]; other site 1144275020448 DNA polymerase III subunit beta; Validated; Region: PRK05643 1144275020449 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1144275020450 putative DNA binding surface [nucleotide binding]; other site 1144275020451 dimer interface [polypeptide binding]; other site 1144275020452 beta-clamp/clamp loader binding surface; other site 1144275020453 beta-clamp/translesion DNA polymerase binding surface; other site 1144275020454 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1144275020455 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1144275020456 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275020457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275020458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275020459 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1144275020460 B12 binding site [chemical binding]; other site 1144275020461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020462 dimer interface [polypeptide binding]; other site 1144275020463 phosphorylation site [posttranslational modification] 1144275020464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020465 ATP binding site [chemical binding]; other site 1144275020466 Mg2+ binding site [ion binding]; other site 1144275020467 G-X-G motif; other site 1144275020468 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020470 active site 1144275020471 phosphorylation site [posttranslational modification] 1144275020472 intermolecular recognition site; other site 1144275020473 dimerization interface [polypeptide binding]; other site 1144275020474 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1144275020475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020476 active site 1144275020477 phosphorylation site [posttranslational modification] 1144275020478 intermolecular recognition site; other site 1144275020479 dimerization interface [polypeptide binding]; other site 1144275020480 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020482 active site 1144275020483 phosphorylation site [posttranslational modification] 1144275020484 intermolecular recognition site; other site 1144275020485 dimerization interface [polypeptide binding]; other site 1144275020486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1144275020487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020488 dimer interface [polypeptide binding]; other site 1144275020489 phosphorylation site [posttranslational modification] 1144275020490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020491 ATP binding site [chemical binding]; other site 1144275020492 Mg2+ binding site [ion binding]; other site 1144275020493 G-X-G motif; other site 1144275020494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020495 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020496 active site 1144275020497 phosphorylation site [posttranslational modification] 1144275020498 intermolecular recognition site; other site 1144275020499 dimerization interface [polypeptide binding]; other site 1144275020500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275020501 non-specific DNA binding site [nucleotide binding]; other site 1144275020502 salt bridge; other site 1144275020503 sequence-specific DNA binding site [nucleotide binding]; other site 1144275020504 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1144275020505 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1144275020506 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1144275020507 FtsX-like permease family; Region: FtsX; cl15850 1144275020508 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1144275020509 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1144275020510 Walker A/P-loop; other site 1144275020511 ATP binding site [chemical binding]; other site 1144275020512 Q-loop/lid; other site 1144275020513 ABC transporter signature motif; other site 1144275020514 Walker B; other site 1144275020515 D-loop; other site 1144275020516 H-loop/switch region; other site 1144275020517 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1144275020518 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275020519 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1144275020520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275020521 dimerization interface [polypeptide binding]; other site 1144275020522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020523 dimer interface [polypeptide binding]; other site 1144275020524 phosphorylation site [posttranslational modification] 1144275020525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020526 ATP binding site [chemical binding]; other site 1144275020527 G-X-G motif; other site 1144275020528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1144275020529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020530 active site 1144275020531 phosphorylation site [posttranslational modification] 1144275020532 intermolecular recognition site; other site 1144275020533 dimerization interface [polypeptide binding]; other site 1144275020534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1144275020535 DNA binding site [nucleotide binding] 1144275020536 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1144275020537 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275020538 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275020539 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275020540 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1144275020541 AMP-binding enzyme; Region: AMP-binding; cl15778 1144275020542 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275020543 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1144275020544 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1144275020545 dimer interface [polypeptide binding]; other site 1144275020546 active site 1144275020547 CoA binding pocket [chemical binding]; other site 1144275020548 Helix-turn-helix domains; Region: HTH; cl00088 1144275020549 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1144275020550 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1144275020551 Helix-turn-helix domains; Region: HTH; cl00088 1144275020552 AsnC family; Region: AsnC_trans_reg; pfam01037 1144275020553 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1144275020554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1144275020555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1144275020556 homodimer interface [polypeptide binding]; other site 1144275020557 catalytic residue [active] 1144275020558 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1144275020559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275020560 NAD(P) binding site [chemical binding]; other site 1144275020561 active site 1144275020562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1144275020563 dimerization interface [polypeptide binding]; other site 1144275020564 putative DNA binding site [nucleotide binding]; other site 1144275020565 putative Zn2+ binding site [ion binding]; other site 1144275020566 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1144275020567 putative FMN binding site [chemical binding]; other site 1144275020568 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1144275020569 active site 1144275020570 catalytic residues [active] 1144275020571 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1144275020572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275020573 S-adenosylmethionine binding site [chemical binding]; other site 1144275020574 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 1144275020575 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020576 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275020577 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1144275020578 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1144275020579 active site residue [active] 1144275020580 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1144275020581 PAS fold; Region: PAS_4; pfam08448 1144275020582 GAF domain; Region: GAF; cl15785 1144275020583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020584 dimer interface [polypeptide binding]; other site 1144275020585 phosphorylation site [posttranslational modification] 1144275020586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020587 ATP binding site [chemical binding]; other site 1144275020588 Mg2+ binding site [ion binding]; other site 1144275020589 G-X-G motif; other site 1144275020590 PAS domain S-box; Region: sensory_box; TIGR00229 1144275020591 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275020592 putative active site [active] 1144275020593 heme pocket [chemical binding]; other site 1144275020594 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1144275020595 GAF domain; Region: GAF; cl15785 1144275020596 PAS fold; Region: PAS_3; pfam08447 1144275020597 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1144275020598 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1144275020599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020600 dimer interface [polypeptide binding]; other site 1144275020601 phosphorylation site [posttranslational modification] 1144275020602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020603 ATP binding site [chemical binding]; other site 1144275020604 Mg2+ binding site [ion binding]; other site 1144275020605 G-X-G motif; other site 1144275020606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020607 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020608 active site 1144275020609 phosphorylation site [posttranslational modification] 1144275020610 intermolecular recognition site; other site 1144275020611 dimerization interface [polypeptide binding]; other site 1144275020612 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275020613 metal ion-dependent adhesion site (MIDAS); other site 1144275020614 hypothetical protein; Validated; Region: PRK09039 1144275020615 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275020616 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1144275020617 Amidinotransferase; Region: Amidinotransf; cl12043 1144275020618 AsmA family; Region: AsmA; pfam05170 1144275020619 AsmA-like C-terminal region; Region: AsmA_2; cl15864 1144275020620 Predicted ATPase [General function prediction only]; Region: COG4637 1144275020621 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1144275020622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020623 ABC transporter signature motif; other site 1144275020624 Walker B; other site 1144275020625 D-loop; other site 1144275020626 H-loop/switch region; other site 1144275020627 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1144275020628 potential frameshift: common BLAST hit: gi|108758771|ref|YP_628458.1| formate--tetrahydrofolate ligase 1144275020629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275020632 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1144275020633 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1144275020634 dimer interface [polypeptide binding]; other site 1144275020635 putative CheW interface [polypeptide binding]; other site 1144275020636 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275020637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020638 active site 1144275020639 phosphorylation site [posttranslational modification] 1144275020640 intermolecular recognition site; other site 1144275020641 dimerization interface [polypeptide binding]; other site 1144275020642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275020643 Walker A motif; other site 1144275020644 ATP binding site [chemical binding]; other site 1144275020645 Walker B motif; other site 1144275020646 arginine finger; other site 1144275020647 Helix-turn-helix domains; Region: HTH; cl00088 1144275020648 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 1144275020649 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1144275020650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1144275020651 dimerization interface [polypeptide binding]; other site 1144275020652 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275020653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275020654 putative active site [active] 1144275020655 heme pocket [chemical binding]; other site 1144275020656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020657 dimer interface [polypeptide binding]; other site 1144275020658 phosphorylation site [posttranslational modification] 1144275020659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020660 ATP binding site [chemical binding]; other site 1144275020661 G-X-G motif; other site 1144275020662 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1144275020663 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1144275020664 Ligand Binding Site [chemical binding]; other site 1144275020665 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1144275020666 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1144275020667 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1144275020668 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1144275020669 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 1144275020670 Fic family protein [Function unknown]; Region: COG3177 1144275020671 Fic/DOC family; Region: Fic; cl00960 1144275020672 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1144275020673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275020674 S-adenosylmethionine binding site [chemical binding]; other site 1144275020675 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 1144275020676 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1144275020677 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275020678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275020679 DNA binding residues [nucleotide binding] 1144275020680 Putative zinc-finger; Region: zf-HC2; cl15806 1144275020681 CHAT domain; Region: CHAT; pfam12770 1144275020682 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1144275020683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020684 active site 1144275020685 phosphorylation site [posttranslational modification] 1144275020686 intermolecular recognition site; other site 1144275020687 dimerization interface [polypeptide binding]; other site 1144275020688 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1144275020689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1144275020690 ATP binding site [chemical binding]; other site 1144275020691 putative Mg++ binding site [ion binding]; other site 1144275020692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1144275020693 nucleotide binding region [chemical binding]; other site 1144275020694 ATP-binding site [chemical binding]; other site 1144275020695 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1144275020696 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1144275020697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020698 Walker A motif; other site 1144275020699 ATP binding site [chemical binding]; other site 1144275020700 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 1144275020701 RxxxH motif; other site 1144275020702 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1144275020703 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020704 Walker A/P-loop; other site 1144275020705 ATP binding site [chemical binding]; other site 1144275020706 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1144275020707 putative active site [active] 1144275020708 putative metal-binding site [ion binding]; other site 1144275020709 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1144275020710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020711 Family description; Region: UvrD_C_2; cl15862 1144275020712 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1144275020713 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1144275020714 HflX GTPase family; Region: HflX; cd01878 1144275020715 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1144275020716 G1 box; other site 1144275020717 GTP/Mg2+ binding site [chemical binding]; other site 1144275020718 Switch I region; other site 1144275020719 G2 box; other site 1144275020720 G3 box; other site 1144275020721 Switch II region; other site 1144275020722 G4 box; other site 1144275020723 G5 box; other site 1144275020724 CAAX protease self-immunity; Region: Abi; cl00558 1144275020725 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1144275020726 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 1144275020727 Walker A/P-loop; other site 1144275020728 ATP binding site [chemical binding]; other site 1144275020729 Q-loop/lid; other site 1144275020730 ABC transporter signature motif; other site 1144275020731 Walker B; other site 1144275020732 D-loop; other site 1144275020733 H-loop/switch region; other site 1144275020734 CHAT domain; Region: CHAT; pfam12770 1144275020735 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1144275020736 Peptidase family M23; Region: Peptidase_M23; pfam01551 1144275020737 GAF domain; Region: GAF; cl15785 1144275020738 GAF domain; Region: GAF_2; pfam13185 1144275020739 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1144275020740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020741 ATP binding site [chemical binding]; other site 1144275020742 Mg2+ binding site [ion binding]; other site 1144275020743 G-X-G motif; other site 1144275020744 short chain dehydrogenase; Provisional; Region: PRK12937 1144275020745 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1144275020746 NADP binding site [chemical binding]; other site 1144275020747 homodimer interface [polypeptide binding]; other site 1144275020748 active site 1144275020749 substrate binding site [chemical binding]; other site 1144275020750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1144275020751 Helix-turn-helix domains; Region: HTH; cl00088 1144275020752 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1144275020753 putative effector binding pocket; other site 1144275020754 putative dimerization interface [polypeptide binding]; other site 1144275020755 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1144275020756 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1144275020757 putative C-terminal domain interface [polypeptide binding]; other site 1144275020758 putative GSH binding site (G-site) [chemical binding]; other site 1144275020759 putative dimer interface [polypeptide binding]; other site 1144275020760 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275020761 N-terminal domain interface [polypeptide binding]; other site 1144275020762 dimer interface [polypeptide binding]; other site 1144275020763 substrate binding pocket (H-site) [chemical binding]; other site 1144275020764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275020765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1144275020766 TPR repeat; Region: TPR_11; pfam13414 1144275020767 binding surface 1144275020768 TPR motif; other site 1144275020769 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1144275020770 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1144275020771 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1144275020772 Right handed beta helix region; Region: Beta_helix; pfam13229 1144275020773 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1144275020774 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1144275020775 Moco binding site; other site 1144275020776 metal coordination site [ion binding]; other site 1144275020777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275020778 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275020780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1144275020781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020782 ATP binding site [chemical binding]; other site 1144275020783 Mg2+ binding site [ion binding]; other site 1144275020784 G-X-G motif; other site 1144275020785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275020786 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1144275020787 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1144275020788 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1144275020789 active site 1144275020790 metal binding site [ion binding]; metal-binding site 1144275020791 DNA binding site [nucleotide binding] 1144275020792 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1144275020793 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1144275020794 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020795 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020796 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020797 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020798 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1144275020799 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1144275020800 structural tetrad; other site 1144275020801 HEAT repeats; Region: HEAT_2; pfam13646 1144275020802 HEAT repeats; Region: HEAT_2; pfam13646 1144275020803 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1144275020804 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1144275020805 HEAT repeats; Region: HEAT_2; pfam13646 1144275020806 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1144275020807 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1144275020808 putative active site [active] 1144275020809 putative NTP binding site [chemical binding]; other site 1144275020810 putative nucleic acid binding site [nucleotide binding]; other site 1144275020811 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020812 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1144275020813 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275020814 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1144275020815 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1144275020816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1144275020817 Helix-turn-helix domains; Region: HTH; cl00088 1144275020818 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1144275020819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1144275020820 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1144275020821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1144275020822 S-adenosylmethionine binding site [chemical binding]; other site 1144275020823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275020824 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1144275020825 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1144275020826 putative active site [active] 1144275020827 catalytic triad [active] 1144275020828 putative dimer interface [polypeptide binding]; other site 1144275020829 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1144275020830 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1144275020831 active site 1144275020832 catalytic residues [active] 1144275020833 metal binding site [ion binding]; metal-binding site 1144275020834 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275020835 L-fuculokinase; Provisional; Region: PRK10331 1144275020836 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275020837 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1144275020838 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1144275020839 active site 1144275020840 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1144275020841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1144275020842 Walker A motif; other site 1144275020843 ATP binding site [chemical binding]; other site 1144275020844 Walker B motif; other site 1144275020845 arginine finger; other site 1144275020846 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1144275020847 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1144275020848 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1144275020849 TPP-binding site [chemical binding]; other site 1144275020850 dimer interface [polypeptide binding]; other site 1144275020851 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1144275020852 PYR/PP interface [polypeptide binding]; other site 1144275020853 dimer interface [polypeptide binding]; other site 1144275020854 TPP binding site [chemical binding]; other site 1144275020855 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1144275020856 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1144275020857 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1144275020858 RNA binding site [nucleotide binding]; other site 1144275020859 active site 1144275020860 Predicted ATPase [General function prediction only]; Region: COG4637 1144275020861 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020862 Walker A/P-loop; other site 1144275020863 ATP binding site [chemical binding]; other site 1144275020864 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1144275020865 LVIVD repeat; Region: LVIVD; pfam08309 1144275020866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020867 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020868 active site 1144275020869 phosphorylation site [posttranslational modification] 1144275020870 intermolecular recognition site; other site 1144275020871 dimerization interface [polypeptide binding]; other site 1144275020872 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1144275020873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 1144275020874 active site 1144275020875 phosphorylation site [posttranslational modification] 1144275020876 intermolecular recognition site; other site 1144275020877 dimerization interface [polypeptide binding]; other site 1144275020878 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020880 active site 1144275020881 phosphorylation site [posttranslational modification] 1144275020882 intermolecular recognition site; other site 1144275020883 dimerization interface [polypeptide binding]; other site 1144275020884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1144275020885 metal binding site [ion binding]; metal-binding site 1144275020886 active site 1144275020887 I-site; other site 1144275020888 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1144275020889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1144275020890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020891 dimer interface [polypeptide binding]; other site 1144275020892 phosphorylation site [posttranslational modification] 1144275020893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020894 ATP binding site [chemical binding]; other site 1144275020895 Mg2+ binding site [ion binding]; other site 1144275020896 G-X-G motif; other site 1144275020897 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020899 active site 1144275020900 phosphorylation site [posttranslational modification] 1144275020901 intermolecular recognition site; other site 1144275020902 dimerization interface [polypeptide binding]; other site 1144275020903 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020905 active site 1144275020906 phosphorylation site [posttranslational modification] 1144275020907 intermolecular recognition site; other site 1144275020908 dimerization interface [polypeptide binding]; other site 1144275020909 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275020910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275020911 active site 1144275020912 phosphorylation site [posttranslational modification] 1144275020913 intermolecular recognition site; other site 1144275020914 dimerization interface [polypeptide binding]; other site 1144275020915 GAF domain; Region: GAF; cl15785 1144275020916 PAS fold; Region: PAS_4; pfam08448 1144275020917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1144275020918 putative active site [active] 1144275020919 heme pocket [chemical binding]; other site 1144275020920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1144275020921 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1144275020922 phosphorylation site [posttranslational modification] 1144275020923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1144275020924 ATP binding site [chemical binding]; other site 1144275020925 Mg2+ binding site [ion binding]; other site 1144275020926 G-X-G motif; other site 1144275020927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275020928 sequence-specific DNA binding site [nucleotide binding]; other site 1144275020929 salt bridge; other site 1144275020930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275020931 non-specific DNA binding site [nucleotide binding]; other site 1144275020932 salt bridge; other site 1144275020933 sequence-specific DNA binding site [nucleotide binding]; other site 1144275020934 Protein kinase domain; Region: Pkinase; pfam00069 1144275020935 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275020936 active site 1144275020937 ATP binding site [chemical binding]; other site 1144275020938 substrate binding site [chemical binding]; other site 1144275020939 activation loop (A-loop); other site 1144275020940 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1144275020941 active site 1144275020942 ATP binding site [chemical binding]; other site 1144275020943 substrate binding site [chemical binding]; other site 1144275020944 activation loop (A-loop); other site 1144275020945 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020946 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020947 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020948 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020949 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020950 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020951 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020952 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020953 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020954 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020955 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020956 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020957 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020958 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020959 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020960 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020961 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020962 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020963 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020964 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020965 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020966 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020967 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020968 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020969 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020970 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020971 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020972 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020973 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020974 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020975 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020976 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020977 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020978 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020979 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020980 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1144275020981 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020982 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1144275020983 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275020984 P loop; other site 1144275020985 Nucleotide binding site [chemical binding]; other site 1144275020986 DTAP/Switch II; other site 1144275020987 Switch I; other site 1144275020988 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1144275020989 DTAP/Switch II; other site 1144275020990 Switch I; other site 1144275020991 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275020992 FOG: CBS domain [General function prediction only]; Region: COG0517 1144275020993 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1144275020994 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1144275020995 iron-sulfur cluster [ion binding]; other site 1144275020996 [2Fe-2S] cluster binding site [ion binding]; other site 1144275020997 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1144275020998 iron-sulfur cluster [ion binding]; other site 1144275020999 [2Fe-2S] cluster binding site [ion binding]; other site 1144275021000 YceI-like domain; Region: YceI; cl01001 1144275021001 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1144275021002 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1144275021003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1144275021004 Coenzyme A binding pocket [chemical binding]; other site 1144275021005 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275021006 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1144275021007 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275021008 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1144275021009 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1144275021010 catalytic residue [active] 1144275021011 Cytochrome c; Region: Cytochrom_C; cl11414 1144275021012 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1144275021013 D-pathway; other site 1144275021014 Low-spin heme binding site [chemical binding]; other site 1144275021015 Putative water exit pathway; other site 1144275021016 Binuclear center (active site) [active] 1144275021017 K-pathway; other site 1144275021018 Putative proton exit pathway; other site 1144275021019 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1144275021020 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1144275021021 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1144275021022 Cu(I) binding site [ion binding]; other site 1144275021023 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1144275021024 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1144275021025 Ligand Binding Site [chemical binding]; other site 1144275021026 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1144275021027 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1144275021028 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1144275021029 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1144275021030 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275021031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275021032 active site 1144275021033 phosphorylation site [posttranslational modification] 1144275021034 intermolecular recognition site; other site 1144275021035 dimerization interface [polypeptide binding]; other site 1144275021036 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1144275021037 cyclase homology domain; Region: CHD; cd07302 1144275021038 nucleotidyl binding site; other site 1144275021039 metal binding site [ion binding]; metal-binding site 1144275021040 dimer interface [polypeptide binding]; other site 1144275021041 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275021042 putative active site [active] 1144275021043 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1144275021044 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1144275021045 putative acyl-acceptor binding pocket; other site 1144275021046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1144275021047 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1144275021048 Proline dehydrogenase; Region: Pro_dh; cl03282 1144275021049 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1144275021050 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1144275021051 PYR/PP interface [polypeptide binding]; other site 1144275021052 dimer interface [polypeptide binding]; other site 1144275021053 tetramer interface [polypeptide binding]; other site 1144275021054 TPP binding site [chemical binding]; other site 1144275021055 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1144275021056 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1144275021057 TPP-binding site [chemical binding]; other site 1144275021058 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1144275021059 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1144275021060 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1144275021061 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1144275021062 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1144275021063 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1144275021064 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 1144275021065 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 1144275021066 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1144275021067 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1144275021068 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1144275021069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1144275021070 AAA domain; Region: AAA_21; pfam13304 1144275021071 Walker A/P-loop; other site 1144275021072 ATP binding site [chemical binding]; other site 1144275021073 ABC transporter signature motif; other site 1144275021074 Walker B; other site 1144275021075 D-loop; other site 1144275021076 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1144275021077 Subunit I/III interface [polypeptide binding]; other site 1144275021078 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1144275021079 D-pathway; other site 1144275021080 Low-spin heme binding site [chemical binding]; other site 1144275021081 Putative water exit pathway; other site 1144275021082 Binuclear center (active site) [active] 1144275021083 K-pathway; other site 1144275021084 Putative proton exit pathway; other site 1144275021085 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1144275021086 Cytochrome c; Region: Cytochrom_C; cl11414 1144275021087 Cytochrome c; Region: Cytochrom_C; cl11414 1144275021088 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1144275021089 Polysulphide reductase, NrfD; Region: NrfD; cl01295 1144275021090 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1144275021091 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275021092 molybdopterin cofactor binding site; other site 1144275021093 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1144275021094 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1144275021095 4Fe-4S binding domain; Region: Fer4; cl02805 1144275021096 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1144275021097 heme-binding residues [chemical binding]; other site 1144275021098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275021099 active site 1144275021100 ATP binding site [chemical binding]; other site 1144275021101 substrate binding site [chemical binding]; other site 1144275021102 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1144275021103 substrate binding site [chemical binding]; other site 1144275021104 activation loop (A-loop); other site 1144275021105 short chain dehydrogenase; Provisional; Region: PRK05872 1144275021106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275021107 NAD(P) binding site [chemical binding]; other site 1144275021108 active site 1144275021109 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1144275021110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275021111 active site 1144275021112 phosphorylation site [posttranslational modification] 1144275021113 intermolecular recognition site; other site 1144275021114 dimerization interface [polypeptide binding]; other site 1144275021115 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275021116 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275021117 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1144275021118 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275021119 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1144275021120 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1144275021121 molybdopterin cofactor binding site; other site 1144275021122 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1144275021123 4Fe-4S binding domain; Region: Fer4; cl02805 1144275021124 Polysulphide reductase, NrfD; Region: NrfD; cl01295 1144275021125 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1144275021126 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1144275021127 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1144275021128 GTP binding site; other site 1144275021129 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1144275021130 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1144275021131 dimer interface [polypeptide binding]; other site 1144275021132 putative functional site; other site 1144275021133 putative MPT binding site; other site 1144275021134 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1144275021135 Walker A motif; other site 1144275021136 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1144275021137 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1144275021138 Bacterial sugar transferase; Region: Bac_transf; cl00939 1144275021139 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1144275021140 MatE; Region: MatE; cl10513 1144275021141 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1144275021142 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1144275021143 Response regulator receiver domain; Region: Response_reg; pfam00072 1144275021144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275021145 active site 1144275021146 phosphorylation site [posttranslational modification] 1144275021147 intermolecular recognition site; other site 1144275021148 dimerization interface [polypeptide binding]; other site 1144275021149 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1144275021150 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1144275021151 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1144275021152 DXD motif; other site 1144275021153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275021154 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1144275021155 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1144275021156 DNA binding residues [nucleotide binding] 1144275021157 dimer interface [polypeptide binding]; other site 1144275021158 metal binding site [ion binding]; metal-binding site 1144275021159 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1144275021160 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1144275021161 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1144275021162 O-Antigen ligase; Region: Wzy_C; cl04850 1144275021163 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 1144275021164 Cation efflux family; Region: Cation_efflux; cl00316 1144275021165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1144275021166 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1144275021167 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1144275021168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1144275021169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1144275021170 DNA binding residues [nucleotide binding] 1144275021171 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1144275021172 putative ADP-binding pocket [chemical binding]; other site 1144275021173 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 1144275021174 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275021175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1144275021176 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1144275021177 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1144275021178 trimer interface [polypeptide binding]; other site 1144275021179 active site 1144275021180 substrate binding site [chemical binding]; other site 1144275021181 CoA binding site [chemical binding]; other site 1144275021182 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 1144275021183 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1144275021184 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1144275021185 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1144275021186 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1144275021187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1144275021188 non-specific DNA binding site [nucleotide binding]; other site 1144275021189 salt bridge; other site 1144275021190 sequence-specific DNA binding site [nucleotide binding]; other site 1144275021191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1144275021192 active site 1144275021193 phosphorylation site [posttranslational modification] 1144275021194 intermolecular recognition site; other site 1144275021195 dimerization interface [polypeptide binding]; other site 1144275021196 TIGR03440 family protein; Region: unchr_TIGR03440 1144275021197 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1144275021198 probable methyltransferase; Region: TIGR03438 1144275021199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275021200 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1144275021201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275021202 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1144275021203 ParB-like partition proteins; Region: parB_part; TIGR00180 1144275021204 ParB-like nuclease domain; Region: ParBc; cl02129 1144275021205 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1144275021206 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275021207 P-loop; other site 1144275021208 Magnesium ion binding site [ion binding]; other site 1144275021209 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1144275021210 Magnesium ion binding site [ion binding]; other site 1144275021211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1144275021212 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1144275021213 active site 1144275021214 metal binding site [ion binding]; metal-binding site 1144275021215 oxidoreductase; Provisional; Region: PRK06196 1144275021216 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1144275021217 putative NAD(P) binding site [chemical binding]; other site 1144275021218 active site 1144275021219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1144275021220 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1144275021221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1144275021222 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1144275021223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275021224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1144275021225 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1144275021226 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1144275021227 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1144275021228 C-terminal domain interface [polypeptide binding]; other site 1144275021229 GSH binding site (G-site) [chemical binding]; other site 1144275021230 dimer interface [polypeptide binding]; other site 1144275021231 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1144275021232 N-terminal domain interface [polypeptide binding]; other site 1144275021233 dimer interface [polypeptide binding]; other site 1144275021234 substrate binding pocket (H-site) [chemical binding]; other site 1144275021235 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1144275021236 putative ADP-ribose binding site [chemical binding]; other site 1144275021237 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275021238 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275021239 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275021240 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1144275021241 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1144275021242 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1144275021243 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275021244 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1144275021245 DDE superfamily endonuclease; Region: DDE_4; cl15789 1144275021246 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1144275021247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1144275021248 active site 1144275021249 catalytic tetrad [active] 1144275021250 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1144275021251 tandem repeat interface [polypeptide binding]; other site 1144275021252 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1144275021253 oligomer interface [polypeptide binding]; other site 1144275021254 active site residues [active] 1144275021255 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1144275021256 tandem repeat interface [polypeptide binding]; other site 1144275021257 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1144275021258 oligomer interface [polypeptide binding]; other site 1144275021259 active site residues [active] 1144275021260 Cysteine dioxygenase type I; Region: CDO_I; cl15835 1144275021261 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1144275021262 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1144275021263 putative active site [active] 1144275021264 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1144275021265 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1144275021266 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1144275021267 G1 box; other site 1144275021268 GTP/Mg2+ binding site [chemical binding]; other site 1144275021269 Switch I region; other site 1144275021270 G2 box; other site 1144275021271 Switch II region; other site 1144275021272 G3 box; other site 1144275021273 G4 box; other site 1144275021274 G5 box; other site 1144275021275 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1144275021276 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1144275021277 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1144275021278 G-X-X-G motif; other site 1144275021279 membrane protein insertase; Provisional; Region: PRK01318 1144275021280 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1144275021281 Haemolytic domain; Region: Haemolytic; cl00506 1144275021282 Ribonuclease P; Region: Ribonuclease_P; cl00457 1144275021283 Ribosomal protein L34; Region: Ribosomal_L34; cl00370