-- dump date 20120504_142737 -- class Genbank::misc_feature -- table misc_feature_note -- id note 698968000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698968000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968000003 Walker A motif; other site 698968000004 ATP binding site [chemical binding]; other site 698968000005 Walker B motif; other site 698968000006 arginine finger; other site 698968000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 698968000008 DnaA box-binding interface [nucleotide binding]; other site 698968000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 698968000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 698968000011 putative DNA binding surface [nucleotide binding]; other site 698968000012 dimer interface [polypeptide binding]; other site 698968000013 beta-clamp/clamp loader binding surface; other site 698968000014 beta-clamp/translesion DNA polymerase binding surface; other site 698968000015 recombination protein F; Reviewed; Region: recF; PRK00064 698968000016 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 698968000017 Walker A/P-loop; other site 698968000018 ATP binding site [chemical binding]; other site 698968000019 Q-loop/lid; other site 698968000020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968000021 ABC transporter signature motif; other site 698968000022 Walker B; other site 698968000023 D-loop; other site 698968000024 H-loop/switch region; other site 698968000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 698968000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 698968000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000028 ATP binding site [chemical binding]; other site 698968000029 Mg2+ binding site [ion binding]; other site 698968000030 G-X-G motif; other site 698968000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 698968000032 anchoring element; other site 698968000033 dimer interface [polypeptide binding]; other site 698968000034 ATP binding site [chemical binding]; other site 698968000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 698968000036 active site 698968000037 putative metal-binding site [ion binding]; other site 698968000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 698968000039 DNA gyrase subunit A; Validated; Region: PRK05560 698968000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 698968000041 CAP-like domain; other site 698968000042 active site 698968000043 primary dimer interface [polypeptide binding]; other site 698968000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 698968000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 698968000051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968000052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968000053 DNA-binding site [nucleotide binding]; DNA binding site 698968000054 FCD domain; Region: FCD; cl11656 698968000055 glycolate transporter; Provisional; Region: PRK09695 698968000056 L-lactate permease; Region: Lactate_perm; cl00701 698968000057 Cadherin repeat-like domain; Region: CA_like; cl15786 698968000058 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968000059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968000060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968000061 Walker A/P-loop; other site 698968000062 ATP binding site [chemical binding]; other site 698968000063 Q-loop/lid; other site 698968000064 ABC transporter signature motif; other site 698968000065 Walker B; other site 698968000066 D-loop; other site 698968000067 H-loop/switch region; other site 698968000068 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 698968000069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968000070 Walker A/P-loop; other site 698968000071 ATP binding site [chemical binding]; other site 698968000072 Q-loop/lid; other site 698968000073 ABC transporter signature motif; other site 698968000074 Walker B; other site 698968000075 D-loop; other site 698968000076 H-loop/switch region; other site 698968000077 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698968000078 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 698968000079 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 698968000080 putative ligand binding site [chemical binding]; other site 698968000081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 698968000082 TM-ABC transporter signature motif; other site 698968000083 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698968000084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968000085 Walker A/P-loop; other site 698968000086 ATP binding site [chemical binding]; other site 698968000087 Q-loop/lid; other site 698968000088 ABC transporter signature motif; other site 698968000089 Walker B; other site 698968000090 D-loop; other site 698968000091 H-loop/switch region; other site 698968000092 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 698968000093 active site 698968000094 Helix-turn-helix domains; Region: HTH; cl00088 698968000095 putative transposase OrfB; Reviewed; Region: PHA02517 698968000096 Rhomboid family; Region: Rhomboid; cl11446 698968000097 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 698968000098 ThiC-associated domain; Region: ThiC-associated; pfam13667 698968000099 ThiC family; Region: ThiC; cl08031 698968000100 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 698968000101 thiamine phosphate binding site [chemical binding]; other site 698968000102 active site 698968000103 pyrophosphate binding site [ion binding]; other site 698968000104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000105 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 698968000106 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 698968000107 ThiS interaction site; other site 698968000108 putative active site [active] 698968000109 tetramer interface [polypeptide binding]; other site 698968000110 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 698968000111 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698968000112 ATP binding site [chemical binding]; other site 698968000113 substrate interface [chemical binding]; other site 698968000114 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698968000115 active site residue [active] 698968000116 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 698968000117 dimer interface [polypeptide binding]; other site 698968000118 substrate binding site [chemical binding]; other site 698968000119 ATP binding site [chemical binding]; other site 698968000120 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 698968000121 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698968000122 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698968000123 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 698968000124 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 698968000125 Helix-turn-helix domains; Region: HTH; cl00088 698968000126 potential frameshift: common BLAST hit: gi|336326698|ref|YP_004606664.1| transposase for insertion sequence element 698968000127 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968000128 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968000129 MULE transposase domain; Region: MULE; pfam10551 698968000130 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 698968000131 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698968000132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968000133 active site 698968000134 ATP binding site [chemical binding]; other site 698968000135 substrate binding site [chemical binding]; other site 698968000136 activation loop (A-loop); other site 698968000137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698968000138 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968000139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968000141 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 698968000142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968000143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698968000144 active site 698968000145 ATP binding site [chemical binding]; other site 698968000146 substrate binding site [chemical binding]; other site 698968000147 activation loop (A-loop); other site 698968000148 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698968000149 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 698968000150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968000151 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 698968000152 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 698968000153 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 698968000154 active site 698968000155 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698968000156 phosphopeptide binding site; other site 698968000157 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 698968000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698968000159 phosphopeptide binding site; other site 698968000160 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698968000161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 698968000162 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698968000163 metal-binding site [ion binding] 698968000164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968000165 dimerization interface [polypeptide binding]; other site 698968000166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968000167 dimer interface [polypeptide binding]; other site 698968000168 phosphorylation site [posttranslational modification] 698968000169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000170 ATP binding site [chemical binding]; other site 698968000171 Mg2+ binding site [ion binding]; other site 698968000172 G-X-G motif; other site 698968000173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968000174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000175 active site 698968000176 phosphorylation site [posttranslational modification] 698968000177 intermolecular recognition site; other site 698968000178 dimerization interface [polypeptide binding]; other site 698968000179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968000180 DNA binding site [nucleotide binding] 698968000181 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 698968000182 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698968000183 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698968000184 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698968000185 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698968000186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000187 dimerization interface [polypeptide binding]; other site 698968000188 putative DNA binding site [nucleotide binding]; other site 698968000189 putative Zn2+ binding site [ion binding]; other site 698968000190 Cadmium resistance transporter; Region: Cad; pfam03596 698968000191 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 698968000192 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 698968000193 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968000194 endonuclease III; Region: ENDO3c; smart00478 698968000195 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968000196 mercuric reductase; Region: MerA; TIGR02053 698968000197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968000198 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968000199 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698968000200 catalytic residues [active] 698968000201 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698968000202 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 698968000203 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 698968000204 DNA binding residues [nucleotide binding] 698968000205 dimer interface [polypeptide binding]; other site 698968000206 metal binding site [ion binding]; metal-binding site 698968000207 NIPSNAP; Region: NIPSNAP; pfam07978 698968000208 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698968000209 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 698968000210 Helix-turn-helix domains; Region: HTH; cl00088 698968000211 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 698968000212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000213 dimerization interface [polypeptide binding]; other site 698968000214 putative DNA binding site [nucleotide binding]; other site 698968000215 putative Zn2+ binding site [ion binding]; other site 698968000216 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 698968000217 Membrane transport protein; Region: Mem_trans; cl09117 698968000218 Low molecular weight phosphatase family; Region: LMWPc; cl00105 698968000219 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 698968000220 active site 698968000221 Predicted permease; Region: DUF318; pfam03773 698968000222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000223 dimerization interface [polypeptide binding]; other site 698968000224 putative DNA binding site [nucleotide binding]; other site 698968000225 putative Zn2+ binding site [ion binding]; other site 698968000226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968000227 non-specific DNA binding site [nucleotide binding]; other site 698968000228 salt bridge; other site 698968000229 sequence-specific DNA binding site [nucleotide binding]; other site 698968000230 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 698968000231 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698968000232 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 698968000233 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 698968000234 Walker A/P-loop; other site 698968000235 ATP binding site [chemical binding]; other site 698968000236 Q-loop/lid; other site 698968000237 ABC transporter signature motif; other site 698968000238 Walker B; other site 698968000239 D-loop; other site 698968000240 H-loop/switch region; other site 698968000241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968000242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000243 active site 698968000244 phosphorylation site [posttranslational modification] 698968000245 intermolecular recognition site; other site 698968000246 dimerization interface [polypeptide binding]; other site 698968000247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968000248 DNA binding residues [nucleotide binding] 698968000249 dimerization interface [polypeptide binding]; other site 698968000250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968000251 Histidine kinase; Region: HisKA_3; pfam07730 698968000252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698968000253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968000254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968000255 dimer interface [polypeptide binding]; other site 698968000256 conserved gate region; other site 698968000257 putative PBP binding loops; other site 698968000258 ABC-ATPase subunit interface; other site 698968000259 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 698968000260 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 698968000261 Walker A/P-loop; other site 698968000262 ATP binding site [chemical binding]; other site 698968000263 Q-loop/lid; other site 698968000264 ABC transporter signature motif; other site 698968000265 Walker B; other site 698968000266 D-loop; other site 698968000267 H-loop/switch region; other site 698968000268 Anti-sigma-K factor rskA; Region: RskA; pfam10099 698968000269 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 698968000270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968000271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968000272 DNA binding residues [nucleotide binding] 698968000273 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698968000274 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 698968000275 catalytic residues [active] 698968000276 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 698968000277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968000278 DNA binding residues [nucleotide binding] 698968000279 dimer interface [polypeptide binding]; other site 698968000280 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 698968000281 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 698968000282 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 698968000283 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 698968000284 putative metal binding site [ion binding]; other site 698968000285 biotin synthase; Validated; Region: PRK06256 698968000286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968000287 FeS/SAM binding site; other site 698968000288 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 698968000289 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 698968000290 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 698968000291 putative ligand binding residues [chemical binding]; other site 698968000292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968000293 ABC-ATPase subunit interface; other site 698968000294 dimer interface [polypeptide binding]; other site 698968000295 putative PBP binding regions; other site 698968000296 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968000297 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968000298 Walker A/P-loop; other site 698968000299 ATP binding site [chemical binding]; other site 698968000300 Q-loop/lid; other site 698968000301 ABC transporter signature motif; other site 698968000302 Walker B; other site 698968000303 D-loop; other site 698968000304 H-loop/switch region; other site 698968000305 Protein of unknown function (DUF419); Region: DUF419; cl15265 698968000306 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 698968000307 DNA photolyase; Region: DNA_photolyase; pfam00875 698968000308 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 698968000309 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 698968000310 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 698968000311 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 698968000312 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968000313 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 698968000314 dimer interface [polypeptide binding]; other site 698968000315 FMN binding site [chemical binding]; other site 698968000316 Helix-turn-helix domains; Region: HTH; cl00088 698968000317 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 698968000318 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 698968000319 trimer interface [polypeptide binding]; other site 698968000320 putative metal binding site [ion binding]; other site 698968000321 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968000322 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 698968000323 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 698968000324 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 698968000325 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968000326 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 698968000327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 698968000328 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698968000329 Helix-turn-helix domains; Region: HTH; cl00088 698968000330 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 698968000331 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698968000332 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 698968000333 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 698968000334 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 698968000335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968000336 ATP binding site [chemical binding]; other site 698968000337 putative Mg++ binding site [ion binding]; other site 698968000338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968000339 nucleotide binding region [chemical binding]; other site 698968000340 Helicase associated domain (HA2); Region: HA2; cl04503 698968000341 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 698968000342 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 698968000343 active site 698968000344 substrate binding site [chemical binding]; other site 698968000345 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 698968000346 trimer interface [polypeptide binding]; other site 698968000347 CoA binding site [chemical binding]; other site 698968000348 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 698968000349 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 698968000350 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 698968000351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000352 NAD(P) binding site [chemical binding]; other site 698968000353 active site 698968000354 LysE type translocator; Region: LysE; cl00565 698968000355 Helix-turn-helix domains; Region: HTH; cl00088 698968000356 Integrase core domain; Region: rve_3; cl15866 698968000357 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 698968000358 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 698968000359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 698968000360 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698968000361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698968000362 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 698968000363 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 698968000364 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 698968000365 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 698968000366 active site 698968000367 Zn binding site [ion binding]; other site 698968000368 Protease prsW family; Region: PrsW-protease; cl15823 698968000369 NMT1-like family; Region: NMT1_2; cl15260 698968000370 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 698968000371 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 698968000372 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 698968000373 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 698968000374 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698968000375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000376 NAD(P) binding site [chemical binding]; other site 698968000377 active site 698968000378 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 698968000379 FAD binding domain; Region: FAD_binding_4; pfam01565 698968000380 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 698968000381 GtrA-like protein; Region: GtrA; cl00971 698968000382 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968000383 putative active site [active] 698968000384 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698968000385 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968000386 active site 698968000387 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968000388 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698968000389 intersubunit interface [polypeptide binding]; other site 698968000390 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698968000391 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 698968000392 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968000393 ABC-ATPase subunit interface; other site 698968000394 dimer interface [polypeptide binding]; other site 698968000395 putative PBP binding regions; other site 698968000396 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968000397 ABC-ATPase subunit interface; other site 698968000398 dimer interface [polypeptide binding]; other site 698968000399 putative PBP binding regions; other site 698968000400 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968000401 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698968000402 intersubunit interface [polypeptide binding]; other site 698968000403 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 698968000404 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 698968000405 Walker A/P-loop; other site 698968000406 ATP binding site [chemical binding]; other site 698968000407 Q-loop/lid; other site 698968000408 ABC transporter signature motif; other site 698968000409 Walker B; other site 698968000410 D-loop; other site 698968000411 H-loop/switch region; other site 698968000412 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698968000413 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698968000414 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968000415 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968000416 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 698968000417 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 698968000418 NAD(P) binding site [chemical binding]; other site 698968000419 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 698968000420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968000421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000422 homodimer interface [polypeptide binding]; other site 698968000423 catalytic residue [active] 698968000424 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 698968000425 transmembrane helices; other site 698968000426 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 698968000427 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 698968000428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968000429 DNA-binding site [nucleotide binding]; DNA binding site 698968000430 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968000431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000432 homodimer interface [polypeptide binding]; other site 698968000433 catalytic residue [active] 698968000434 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 698968000435 active site 698968000436 multimer interface [polypeptide binding]; other site 698968000437 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 698968000438 predicted active site [active] 698968000439 catalytic triad [active] 698968000440 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698968000441 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968000442 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000443 active site 698968000444 catalytic site [active] 698968000445 Fibronectin type III-like domain; Region: Fn3-like; cl15273 698968000446 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000447 active site 698968000448 catalytic site [active] 698968000449 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698968000450 metal ion-dependent adhesion site (MIDAS); other site 698968000451 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 698968000452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000453 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 698968000454 nucleoside/Zn binding site; other site 698968000455 dimer interface [polypeptide binding]; other site 698968000456 catalytic motif [active] 698968000457 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 698968000458 DNA binding residues [nucleotide binding] 698968000459 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 698968000460 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698968000461 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 698968000462 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 698968000463 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 698968000464 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968000465 active site 698968000466 HIGH motif; other site 698968000467 nucleotide binding site [chemical binding]; other site 698968000468 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968000469 active site 698968000470 KMSKS motif; other site 698968000471 GntP family permease; Region: GntP_permease; pfam02447 698968000472 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 698968000473 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 698968000474 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 698968000475 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 698968000476 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 698968000477 putative NAD(P) binding site [chemical binding]; other site 698968000478 catalytic Zn binding site [ion binding]; other site 698968000479 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 698968000480 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 698968000481 NADP binding site [chemical binding]; other site 698968000482 homodimer interface [polypeptide binding]; other site 698968000483 active site 698968000484 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 698968000485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968000486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000487 homodimer interface [polypeptide binding]; other site 698968000488 catalytic residue [active] 698968000489 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 698968000490 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 698968000491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968000492 Walker A motif; other site 698968000493 ATP binding site [chemical binding]; other site 698968000494 Walker B motif; other site 698968000495 arginine finger; other site 698968000496 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 698968000497 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 698968000498 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 698968000499 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 698968000500 recombination protein RecR; Reviewed; Region: recR; PRK00076 698968000501 RecR protein; Region: RecR; pfam02132 698968000502 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 698968000503 putative active site [active] 698968000504 putative metal-binding site [ion binding]; other site 698968000505 tetramer interface [polypeptide binding]; other site 698968000506 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698968000507 catalytic triad [active] 698968000508 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 698968000509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968000510 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 698968000511 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 698968000512 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698968000513 active site 698968000514 catalytic site [active] 698968000515 substrate binding site [chemical binding]; other site 698968000516 potential frameshift: common BLAST hit: gi|38232888|ref|NP_938655.1| nitroreductase 698968000517 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 698968000518 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 698968000519 dimer interface [polypeptide binding]; other site 698968000520 FMN binding site [chemical binding]; other site 698968000521 2-isopropylmalate synthase; Validated; Region: PRK03739 698968000522 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 698968000523 active site 698968000524 catalytic residues [active] 698968000525 metal binding site [ion binding]; metal-binding site 698968000526 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 698968000527 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 698968000528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968000529 DNA binding residues [nucleotide binding] 698968000530 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 698968000531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968000532 active site 698968000533 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 698968000534 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698968000535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968000536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000537 putative substrate translocation pore; other site 698968000538 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 698968000539 intersubunit interface [polypeptide binding]; other site 698968000540 active site 698968000541 catalytic residue [active] 698968000542 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 698968000543 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 698968000544 active site 698968000545 substrate binding site [chemical binding]; other site 698968000546 metal binding site [ion binding]; metal-binding site 698968000547 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 698968000548 aspartate kinase; Reviewed; Region: PRK06635 698968000549 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 698968000550 putative nucleotide binding site [chemical binding]; other site 698968000551 putative catalytic residues [active] 698968000552 putative Mg ion binding site [ion binding]; other site 698968000553 putative aspartate binding site [chemical binding]; other site 698968000554 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 698968000555 putative allosteric regulatory site; other site 698968000556 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 698968000557 putative allosteric regulatory residue; other site 698968000558 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 698968000559 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 698968000560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000561 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698968000562 potential frameshift: common BLAST hit: gi|172040440|ref|YP_001800154.1| transposase for insertion sequence 698968000563 Helix-turn-helix domains; Region: HTH; cl00088 698968000564 potential frameshift: common BLAST hit: gi|38234519|ref|NP_940286.1| transposase 698968000565 HTH-like domain; Region: HTH_21; pfam13276 698968000566 Integrase core domain; Region: rve; cl01316 698968000567 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 698968000568 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698968000569 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698968000570 Fibronectin type III-like domain; Region: Fn3-like; cl15273 698968000571 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000572 active site 698968000573 catalytic site [active] 698968000574 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968000575 active site 698968000576 catalytic site [active] 698968000577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968000578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698968000579 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 698968000580 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 698968000581 heme binding pocket [chemical binding]; other site 698968000582 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 698968000583 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 698968000584 Walker A/P-loop; other site 698968000585 ATP binding site [chemical binding]; other site 698968000586 Q-loop/lid; other site 698968000587 ABC transporter signature motif; other site 698968000588 Walker B; other site 698968000589 D-loop; other site 698968000590 H-loop/switch region; other site 698968000591 TOBE domain; Region: TOBE_2; cl01440 698968000592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968000593 dimer interface [polypeptide binding]; other site 698968000594 conserved gate region; other site 698968000595 ABC-ATPase subunit interface; other site 698968000596 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698968000597 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 698968000598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000599 putative substrate translocation pore; other site 698968000600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000601 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968000602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000603 active site 698968000604 phosphorylation site [posttranslational modification] 698968000605 intermolecular recognition site; other site 698968000606 dimerization interface [polypeptide binding]; other site 698968000607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968000608 DNA binding site [nucleotide binding] 698968000609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968000610 dimer interface [polypeptide binding]; other site 698968000611 phosphorylation site [posttranslational modification] 698968000612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000613 ATP binding site [chemical binding]; other site 698968000614 Mg2+ binding site [ion binding]; other site 698968000615 G-X-G motif; other site 698968000616 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 698968000617 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 698968000618 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 698968000619 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 698968000620 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698968000621 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 698968000622 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 698968000623 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 698968000624 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698968000625 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698968000626 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 698968000627 Predicted membrane protein [Function unknown]; Region: COG1511 698968000628 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968000629 putative active site [active] 698968000630 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698968000631 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 698968000632 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 698968000633 putative active site [active] 698968000634 putative metal binding site [ion binding]; other site 698968000635 GatB domain; Region: GatB_Yqey; cl11497 698968000636 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698968000637 Transglycosylase; Region: Transgly; cl07896 698968000638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968000639 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 698968000640 Transcription factor WhiB; Region: Whib; pfam02467 698968000641 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 698968000642 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 698968000643 homotrimer interaction site [polypeptide binding]; other site 698968000644 putative active site [active] 698968000645 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698968000646 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 698968000647 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698968000648 ligand binding site [chemical binding]; other site 698968000649 flexible hinge region; other site 698968000650 Helix-turn-helix domains; Region: HTH; cl00088 698968000651 putative switch regulator; other site 698968000652 non-specific DNA interactions [nucleotide binding]; other site 698968000653 DNA binding site [nucleotide binding] 698968000654 sequence specific DNA binding site [nucleotide binding]; other site 698968000655 putative cAMP binding site [chemical binding]; other site 698968000656 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 698968000657 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698968000658 minor groove reading motif; other site 698968000659 helix-hairpin-helix signature motif; other site 698968000660 substrate binding pocket [chemical binding]; other site 698968000661 active site 698968000662 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 698968000663 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698968000664 catalytic residues [active] 698968000665 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 698968000666 putative active site [active] 698968000667 putative CoA binding site [chemical binding]; other site 698968000668 nudix motif; other site 698968000669 metal binding site [ion binding]; metal-binding site 698968000670 Colicin V production protein; Region: Colicin_V; cl00567 698968000671 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698968000672 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968000673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968000674 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 698968000675 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698968000676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968000677 motif II; other site 698968000678 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 698968000679 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 698968000680 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 698968000681 ATP binding site [chemical binding]; other site 698968000682 Walker A motif; other site 698968000683 hexamer interface [polypeptide binding]; other site 698968000684 Walker B motif; other site 698968000685 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 698968000686 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 698968000687 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 698968000688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968000689 ATP binding site [chemical binding]; other site 698968000690 putative Mg++ binding site [ion binding]; other site 698968000691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968000692 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 698968000693 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 698968000694 DNA-binding site [nucleotide binding]; DNA binding site 698968000695 RNA-binding motif; other site 698968000696 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698968000697 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968000698 Walker A/P-loop; other site 698968000699 ATP binding site [chemical binding]; other site 698968000700 Q-loop/lid; other site 698968000701 ABC transporter signature motif; other site 698968000702 Walker B; other site 698968000703 D-loop; other site 698968000704 H-loop/switch region; other site 698968000705 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968000706 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698968000707 Walker A/P-loop; other site 698968000708 ATP binding site [chemical binding]; other site 698968000709 Q-loop/lid; other site 698968000710 ABC transporter signature motif; other site 698968000711 Walker B; other site 698968000712 D-loop; other site 698968000713 H-loop/switch region; other site 698968000714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968000715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968000716 putative substrate translocation pore; other site 698968000717 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 698968000718 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698968000719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968000720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968000721 dimer interface [polypeptide binding]; other site 698968000722 conserved gate region; other site 698968000723 putative PBP binding loops; other site 698968000724 ABC-ATPase subunit interface; other site 698968000725 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 698968000726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000727 NAD(P) binding site [chemical binding]; other site 698968000728 active site 698968000729 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 698968000730 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 698968000731 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 698968000732 active site 698968000733 interdomain interaction site; other site 698968000734 putative metal-binding site [ion binding]; other site 698968000735 nucleotide binding site [chemical binding]; other site 698968000736 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 698968000737 domain I; other site 698968000738 DNA binding groove [nucleotide binding] 698968000739 phosphate binding site [ion binding]; other site 698968000740 domain II; other site 698968000741 domain III; other site 698968000742 nucleotide binding site [chemical binding]; other site 698968000743 catalytic site [active] 698968000744 domain IV; other site 698968000745 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 698968000746 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698968000747 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 698968000748 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698968000749 active site 698968000750 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 698968000751 OPT oligopeptide transporter protein; Region: OPT; cl14607 698968000752 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 698968000753 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698968000754 catalytic site [active] 698968000755 Asp-box motif; other site 698968000756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968000757 dimerization interface [polypeptide binding]; other site 698968000758 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 698968000759 cyclase homology domain; Region: CHD; cd07302 698968000760 nucleotidyl binding site; other site 698968000761 metal binding site [ion binding]; metal-binding site 698968000762 dimer interface [polypeptide binding]; other site 698968000763 DNA polymerase III subunit delta'; Validated; Region: PRK07940 698968000764 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968000765 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 698968000766 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 698968000767 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698968000768 active site 698968000769 DNA binding site [nucleotide binding] 698968000770 Int/Topo IB signature motif; other site 698968000771 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 698968000772 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698968000773 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 698968000774 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698968000775 Fic family protein [Function unknown]; Region: COG3177 698968000776 Fic/DOC family; Region: Fic; cl00960 698968000777 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 698968000778 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698968000779 active site 698968000780 substrate binding sites [chemical binding]; other site 698968000781 putative transposase OrfB; Reviewed; Region: PHA02517 698968000782 HTH-like domain; Region: HTH_21; pfam13276 698968000783 Integrase core domain; Region: rve; cl01316 698968000784 Integrase core domain; Region: rve_3; cl15866 698968000785 Helix-turn-helix domains; Region: HTH; cl00088 698968000786 acyl-CoA synthetase; Validated; Region: PRK07788 698968000787 AMP-binding enzyme; Region: AMP-binding; cl15778 698968000788 AMP-binding enzyme; Region: AMP-binding; cl15778 698968000789 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 698968000790 active site 698968000791 catalytic triad [active] 698968000792 oxyanion hole [active] 698968000793 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 698968000794 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 698968000795 substrate binding site; other site 698968000796 tetramer interface; other site 698968000797 Cupin domain; Region: Cupin_2; cl09118 698968000798 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 698968000799 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 698968000800 NADP binding site [chemical binding]; other site 698968000801 active site 698968000802 putative substrate binding site [chemical binding]; other site 698968000803 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 698968000804 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 698968000805 NAD binding site [chemical binding]; other site 698968000806 substrate binding site [chemical binding]; other site 698968000807 homodimer interface [polypeptide binding]; other site 698968000808 active site 698968000809 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 698968000810 Zn binding site [ion binding]; other site 698968000811 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 698968000812 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968000813 Predicted esterase [General function prediction only]; Region: COG0627 698968000814 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 698968000815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000816 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968000817 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968000818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 698968000819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968000820 non-specific DNA binding site [nucleotide binding]; other site 698968000821 salt bridge; other site 698968000822 sequence-specific DNA binding site [nucleotide binding]; other site 698968000823 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 698968000824 Domain of unknown function (DUF955); Region: DUF955; cl01076 698968000825 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 698968000826 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 698968000827 putative Iron-sulfur protein interface [polypeptide binding]; other site 698968000828 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 698968000829 proximal heme binding site [chemical binding]; other site 698968000830 distal heme binding site [chemical binding]; other site 698968000831 putative dimer interface [polypeptide binding]; other site 698968000832 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 698968000833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000834 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 698968000835 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 698968000836 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 698968000837 Predicted membrane protein [Function unknown]; Region: COG2733 698968000838 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 698968000839 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698968000840 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698968000841 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 698968000842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968000843 FeS/SAM binding site; other site 698968000844 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698968000845 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698968000846 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 698968000847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968000848 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 698968000849 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 698968000850 FAD binding domain; Region: FAD_binding_4; pfam01565 698968000851 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 698968000852 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698968000853 AMP-binding enzyme; Region: AMP-binding; cl15778 698968000854 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 698968000855 AMP-binding enzyme; Region: AMP-binding; cl15778 698968000856 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 698968000857 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 698968000858 putative ADP-binding pocket [chemical binding]; other site 698968000859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968000860 catalytic core [active] 698968000861 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968000862 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 698968000863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968000864 dimer interface [polypeptide binding]; other site 698968000865 phosphorylation site [posttranslational modification] 698968000866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968000867 ATP binding site [chemical binding]; other site 698968000868 Mg2+ binding site [ion binding]; other site 698968000869 G-X-G motif; other site 698968000870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968000871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968000872 active site 698968000873 phosphorylation site [posttranslational modification] 698968000874 intermolecular recognition site; other site 698968000875 dimerization interface [polypeptide binding]; other site 698968000876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968000877 DNA binding site [nucleotide binding] 698968000878 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 698968000879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968000880 NAD(P) binding pocket [chemical binding]; other site 698968000881 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 698968000882 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 698968000883 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698968000884 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 698968000885 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698968000886 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698968000887 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 698968000888 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 698968000889 tRNA; other site 698968000890 putative tRNA binding site [nucleotide binding]; other site 698968000891 putative NADP binding site [chemical binding]; other site 698968000892 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 698968000893 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 698968000894 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 698968000895 domain interfaces; other site 698968000896 active site 698968000897 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968000898 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968000899 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 698968000900 active site 698968000901 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 698968000902 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 698968000903 dimer interface [polypeptide binding]; other site 698968000904 active site 698968000905 Schiff base residues; other site 698968000906 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698968000907 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698968000908 Predicted membrane protein [Function unknown]; Region: COG2311 698968000909 Protein of unknown function (DUF418); Region: DUF418; cl12135 698968000910 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 698968000911 substrate binding site [chemical binding]; other site 698968000912 active site 698968000913 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 698968000914 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 698968000915 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698968000916 inhibitor-cofactor binding pocket; inhibition site 698968000917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968000918 catalytic residue [active] 698968000919 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968000920 catalytic core [active] 698968000921 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 698968000922 catalytic residues [active] 698968000923 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 698968000924 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 698968000925 ResB-like family; Region: ResB; pfam05140 698968000926 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 698968000927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968000928 dimerization interface [polypeptide binding]; other site 698968000929 putative DNA binding site [nucleotide binding]; other site 698968000930 putative Zn2+ binding site [ion binding]; other site 698968000931 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 698968000932 UbiA prenyltransferase family; Region: UbiA; cl00337 698968000933 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968000934 active site 698968000935 AMP-binding enzyme; Region: AMP-binding; cl15778 698968000936 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 698968000937 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 698968000938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698968000939 substrate binding site [chemical binding]; other site 698968000940 oxyanion hole (OAH) forming residues; other site 698968000941 trimer interface [polypeptide binding]; other site 698968000942 O-succinylbenzoate synthase; Provisional; Region: PRK02901 698968000943 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 698968000944 active site 698968000945 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 698968000946 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 698968000947 dimer interface [polypeptide binding]; other site 698968000948 tetramer interface [polypeptide binding]; other site 698968000949 PYR/PP interface [polypeptide binding]; other site 698968000950 TPP binding site [chemical binding]; other site 698968000951 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 698968000952 TPP-binding site; other site 698968000953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968000954 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 698968000955 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698968000956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968000957 S-adenosylmethionine binding site [chemical binding]; other site 698968000958 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 698968000959 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 698968000960 NAD binding site [chemical binding]; other site 698968000961 dimer interface [polypeptide binding]; other site 698968000962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968000963 substrate binding site [chemical binding]; other site 698968000964 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 698968000965 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698968000966 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698968000967 substrate binding pocket [chemical binding]; other site 698968000968 chain length determination region; other site 698968000969 substrate-Mg2+ binding site; other site 698968000970 catalytic residues [active] 698968000971 aspartate-rich region 1; other site 698968000972 active site lid residues [active] 698968000973 aspartate-rich region 2; other site 698968000974 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 698968000975 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 698968000976 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 698968000977 putative homodimer interface [polypeptide binding]; other site 698968000978 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 698968000979 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 698968000980 23S rRNA interface [nucleotide binding]; other site 698968000981 L7/L12 interface [polypeptide binding]; other site 698968000982 putative thiostrepton binding site; other site 698968000983 L25 interface [polypeptide binding]; other site 698968000984 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 698968000985 mRNA/rRNA interface [nucleotide binding]; other site 698968000986 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 698968000987 23S rRNA interface [nucleotide binding]; other site 698968000988 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 698968000989 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 698968000990 L11 interface [polypeptide binding]; other site 698968000991 putative EF-Tu interaction site [polypeptide binding]; other site 698968000992 putative EF-G interaction site [polypeptide binding]; other site 698968000993 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 698968000994 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968000995 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968000996 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968000997 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968000998 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968000999 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 698968001000 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 698968001001 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001002 ABC-ATPase subunit interface; other site 698968001003 dimer interface [polypeptide binding]; other site 698968001004 putative PBP binding regions; other site 698968001005 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968001006 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968001007 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968001008 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968001009 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698968001010 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 698968001011 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 698968001012 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 698968001013 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 698968001014 RPB1 interaction site [polypeptide binding]; other site 698968001015 RPB10 interaction site [polypeptide binding]; other site 698968001016 RPB11 interaction site [polypeptide binding]; other site 698968001017 RPB3 interaction site [polypeptide binding]; other site 698968001018 RPB12 interaction site [polypeptide binding]; other site 698968001019 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 698968001020 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 698968001021 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 698968001022 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 698968001023 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 698968001024 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698968001025 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 698968001026 G-loop; other site 698968001027 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 698968001028 DNA binding site [nucleotide binding] 698968001029 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 698968001030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968001031 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698968001032 Walker A/P-loop; other site 698968001033 ATP binding site [chemical binding]; other site 698968001034 Q-loop/lid; other site 698968001035 ABC transporter signature motif; other site 698968001036 Walker B; other site 698968001037 D-loop; other site 698968001038 H-loop/switch region; other site 698968001039 putative transposase OrfB; Reviewed; Region: PHA02517 698968001040 HTH-like domain; Region: HTH_21; pfam13276 698968001041 Integrase core domain; Region: rve; cl01316 698968001042 Integrase core domain; Region: rve_3; cl15866 698968001043 Helix-turn-helix domains; Region: HTH; cl00088 698968001044 Helix-turn-helix domains; Region: HTH; cl00088 698968001045 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 698968001046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968001047 Histidine kinase; Region: HisKA_3; pfam07730 698968001048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968001049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968001050 active site 698968001051 phosphorylation site [posttranslational modification] 698968001052 intermolecular recognition site; other site 698968001053 dimerization interface [polypeptide binding]; other site 698968001054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968001055 DNA binding residues [nucleotide binding] 698968001056 dimerization interface [polypeptide binding]; other site 698968001057 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968001058 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 698968001059 Walker A/P-loop; other site 698968001060 ATP binding site [chemical binding]; other site 698968001061 Q-loop/lid; other site 698968001062 ABC transporter signature motif; other site 698968001063 Walker B; other site 698968001064 D-loop; other site 698968001065 H-loop/switch region; other site 698968001066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968001067 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698968001068 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 698968001069 Predicted permeases [General function prediction only]; Region: COG0701 698968001070 Predicted permease; Region: DUF318; pfam03773 698968001071 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 698968001072 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968001073 FeS/SAM binding site; other site 698968001074 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 698968001075 Class III ribonucleotide reductase; Region: RNR_III; cd01675 698968001076 effector binding site; other site 698968001077 active site 698968001078 Zn binding site [ion binding]; other site 698968001079 glycine loop; other site 698968001080 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 698968001081 S17 interaction site [polypeptide binding]; other site 698968001082 S8 interaction site; other site 698968001083 16S rRNA interaction site [nucleotide binding]; other site 698968001084 streptomycin interaction site [chemical binding]; other site 698968001085 23S rRNA interaction site [nucleotide binding]; other site 698968001086 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 698968001087 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 698968001088 elongation factor G; Reviewed; Region: PRK00007 698968001089 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 698968001090 G1 box; other site 698968001091 putative GEF interaction site [polypeptide binding]; other site 698968001092 GTP/Mg2+ binding site [chemical binding]; other site 698968001093 Switch I region; other site 698968001094 G2 box; other site 698968001095 G3 box; other site 698968001096 Switch II region; other site 698968001097 G4 box; other site 698968001098 G5 box; other site 698968001099 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 698968001100 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 698968001101 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 698968001102 elongation factor Tu; Reviewed; Region: PRK00049 698968001103 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 698968001104 G1 box; other site 698968001105 GEF interaction site [polypeptide binding]; other site 698968001106 GTP/Mg2+ binding site [chemical binding]; other site 698968001107 Switch I region; other site 698968001108 G2 box; other site 698968001109 G3 box; other site 698968001110 Switch II region; other site 698968001111 G4 box; other site 698968001112 G5 box; other site 698968001113 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 698968001114 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 698968001115 Antibiotic Binding Site [chemical binding]; other site 698968001116 Protein of unknown function (DUF421); Region: DUF421; cl00990 698968001117 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 698968001118 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 698968001119 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 698968001120 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 698968001121 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 698968001122 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 698968001123 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 698968001124 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 698968001125 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 698968001126 putative translocon binding site; other site 698968001127 protein-rRNA interface [nucleotide binding]; other site 698968001128 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 698968001129 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 698968001130 G-X-X-G motif; other site 698968001131 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 698968001132 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 698968001133 23S rRNA interface [nucleotide binding]; other site 698968001134 5S rRNA interface [nucleotide binding]; other site 698968001135 putative antibiotic binding site [chemical binding]; other site 698968001136 L25 interface [polypeptide binding]; other site 698968001137 L27 interface [polypeptide binding]; other site 698968001138 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 698968001139 putative translocon interaction site; other site 698968001140 23S rRNA interface [nucleotide binding]; other site 698968001141 signal recognition particle (SRP54) interaction site; other site 698968001142 L23 interface [polypeptide binding]; other site 698968001143 trigger factor interaction site; other site 698968001144 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 698968001145 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698968001146 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 698968001147 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 698968001148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968001149 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698968001150 Walker A/P-loop; other site 698968001151 ATP binding site [chemical binding]; other site 698968001152 Q-loop/lid; other site 698968001153 ABC transporter signature motif; other site 698968001154 Walker B; other site 698968001155 D-loop; other site 698968001156 H-loop/switch region; other site 698968001157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968001158 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698968001159 FtsX-like permease family; Region: FtsX; cl15850 698968001160 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 698968001161 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 698968001162 KOW motif; Region: KOW; cl00354 698968001163 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 698968001164 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 698968001165 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 698968001166 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 698968001167 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 698968001168 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698968001169 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698968001170 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 698968001171 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698968001172 active site 698968001173 homotetramer interface [polypeptide binding]; other site 698968001174 homodimer interface [polypeptide binding]; other site 698968001175 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 698968001176 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 698968001177 ATP binding site [chemical binding]; other site 698968001178 substrate interface [chemical binding]; other site 698968001179 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698968001180 active site residue [active] 698968001181 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698968001182 MPT binding site; other site 698968001183 trimer interface [polypeptide binding]; other site 698968001184 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 698968001185 MoaE homodimer interface [polypeptide binding]; other site 698968001186 MoaD interaction [polypeptide binding]; other site 698968001187 active site residues [active] 698968001188 Predicted transcriptional regulator [Transcription]; Region: COG2345 698968001189 Helix-turn-helix domains; Region: HTH; cl00088 698968001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001191 dimer interface [polypeptide binding]; other site 698968001192 conserved gate region; other site 698968001193 putative PBP binding loops; other site 698968001194 ABC-ATPase subunit interface; other site 698968001195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001196 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 698968001197 Walker A/P-loop; other site 698968001198 ATP binding site [chemical binding]; other site 698968001199 Q-loop/lid; other site 698968001200 ABC transporter signature motif; other site 698968001201 Walker B; other site 698968001202 D-loop; other site 698968001203 H-loop/switch region; other site 698968001204 TOBE domain; Region: TOBE_2; cl01440 698968001205 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 698968001206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698968001207 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 698968001208 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 698968001209 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 698968001210 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 698968001211 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 698968001212 [4Fe-4S] binding site [ion binding]; other site 698968001213 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698968001214 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698968001215 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 698968001216 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 698968001217 molybdopterin cofactor binding site; other site 698968001218 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 698968001219 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 698968001220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968001221 putative substrate translocation pore; other site 698968001222 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698968001223 MPT binding site; other site 698968001224 trimer interface [polypeptide binding]; other site 698968001225 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 698968001226 GTP binding site; other site 698968001227 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 698968001228 trimer interface [polypeptide binding]; other site 698968001229 dimer interface [polypeptide binding]; other site 698968001230 putative active site [active] 698968001231 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698968001232 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698968001233 dimer interface [polypeptide binding]; other site 698968001234 putative functional site; other site 698968001235 putative MPT binding site; other site 698968001236 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 698968001237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968001238 FeS/SAM binding site; other site 698968001239 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 698968001240 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968001241 endonuclease III; Region: ENDO3c; smart00478 698968001242 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968001243 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698968001244 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698968001245 inhibitor site; inhibition site 698968001246 active site 698968001247 dimer interface [polypeptide binding]; other site 698968001248 catalytic residue [active] 698968001249 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 698968001250 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968001251 Walker A/P-loop; other site 698968001252 ATP binding site [chemical binding]; other site 698968001253 Q-loop/lid; other site 698968001254 ABC transporter signature motif; other site 698968001255 Walker B; other site 698968001256 D-loop; other site 698968001257 H-loop/switch region; other site 698968001258 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968001259 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698968001260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001261 dimer interface [polypeptide binding]; other site 698968001262 conserved gate region; other site 698968001263 putative PBP binding loops; other site 698968001264 ABC-ATPase subunit interface; other site 698968001265 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 698968001266 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968001267 Walker A/P-loop; other site 698968001268 ATP binding site [chemical binding]; other site 698968001269 Q-loop/lid; other site 698968001270 ABC transporter signature motif; other site 698968001271 Walker B; other site 698968001272 D-loop; other site 698968001273 H-loop/switch region; other site 698968001274 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968001275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968001276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001277 dimer interface [polypeptide binding]; other site 698968001278 conserved gate region; other site 698968001279 putative PBP binding loops; other site 698968001280 ABC-ATPase subunit interface; other site 698968001281 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 698968001282 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698968001283 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698968001284 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968001285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968001286 DNA-binding site [nucleotide binding]; DNA binding site 698968001287 FCD domain; Region: FCD; cl11656 698968001288 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968001289 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 698968001290 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 698968001291 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 698968001292 putative active site cavity [active] 698968001293 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 698968001294 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 698968001295 active site 698968001296 dimer interface [polypeptide binding]; other site 698968001297 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 698968001298 active site 698968001299 trimer interface [polypeptide binding]; other site 698968001300 allosteric site; other site 698968001301 active site lid [active] 698968001302 hexamer (dimer of trimers) interface [polypeptide binding]; other site 698968001303 Htaa; Region: HtaA; pfam04213 698968001304 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 698968001305 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 698968001306 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698968001307 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 698968001308 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 698968001309 5S rRNA interface [nucleotide binding]; other site 698968001310 L27 interface [polypeptide binding]; other site 698968001311 23S rRNA interface [nucleotide binding]; other site 698968001312 L5 interface [polypeptide binding]; other site 698968001313 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 698968001314 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 698968001315 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 698968001316 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 698968001317 23S rRNA binding site [nucleotide binding]; other site 698968001318 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 698968001319 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 698968001320 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 698968001321 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 698968001322 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698968001323 active site 698968001324 catalytic site [active] 698968001325 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 698968001326 trehalose synthase; Region: treS_nterm; TIGR02456 698968001327 active site 698968001328 catalytic site [active] 698968001329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698968001330 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 698968001331 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 698968001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001333 dimer interface [polypeptide binding]; other site 698968001334 conserved gate region; other site 698968001335 putative PBP binding loops; other site 698968001336 ABC-ATPase subunit interface; other site 698968001337 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 698968001338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968001339 dimer interface [polypeptide binding]; other site 698968001340 conserved gate region; other site 698968001341 putative PBP binding loops; other site 698968001342 ABC-ATPase subunit interface; other site 698968001343 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 698968001344 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 698968001345 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 698968001346 Walker A/P-loop; other site 698968001347 ATP binding site [chemical binding]; other site 698968001348 Q-loop/lid; other site 698968001349 ABC transporter signature motif; other site 698968001350 Walker B; other site 698968001351 D-loop; other site 698968001352 H-loop/switch region; other site 698968001353 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 698968001354 SecY translocase; Region: SecY; pfam00344 698968001355 adenylate kinase; Reviewed; Region: adk; PRK00279 698968001356 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 698968001357 AMP-binding site [chemical binding]; other site 698968001358 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 698968001359 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698968001360 active site 698968001361 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 698968001362 catalytic site [active] 698968001363 BNR repeat-like domain; Region: BNR_2; pfam13088 698968001364 Asp-box motif; other site 698968001365 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 698968001366 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 698968001367 rRNA binding site [nucleotide binding]; other site 698968001368 predicted 30S ribosome binding site; other site 698968001369 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 698968001370 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 698968001371 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 698968001372 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 698968001373 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 698968001374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968001375 RNA binding surface [nucleotide binding]; other site 698968001376 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 698968001377 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 698968001378 alphaNTD - beta interaction site [polypeptide binding]; other site 698968001379 alphaNTD homodimer interface [polypeptide binding]; other site 698968001380 alphaNTD - beta' interaction site [polypeptide binding]; other site 698968001381 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 698968001382 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 698968001383 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 698968001384 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 698968001385 dimerization interface 3.5A [polypeptide binding]; other site 698968001386 active site 698968001387 Protein of unknown function (DUF690); Region: DUF690; cl04939 698968001388 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 698968001389 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 698968001390 active site 698968001391 catalytic residues [active] 698968001392 Ubiquitin-like proteins; Region: UBQ; cl00155 698968001393 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 698968001394 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001395 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 698968001396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001398 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 698968001399 Proteins of 100 residues with WXG; Region: WXG100; cl02005 698968001400 Proteins of 100 residues with WXG; Region: WXG100; cl02005 698968001401 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 698968001402 23S rRNA interface [nucleotide binding]; other site 698968001403 L3 interface [polypeptide binding]; other site 698968001404 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 698968001405 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 698968001406 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 698968001407 active site 698968001408 substrate binding site [chemical binding]; other site 698968001409 metal binding site [ion binding]; metal-binding site 698968001410 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 698968001411 alanine racemase; Reviewed; Region: alr; PRK00053 698968001412 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 698968001413 active site 698968001414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698968001415 dimer interface [polypeptide binding]; other site 698968001416 substrate binding site [chemical binding]; other site 698968001417 catalytic residues [active] 698968001418 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 698968001419 Predicted permease [General function prediction only]; Region: COG2985 698968001420 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 698968001421 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698968001422 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 698968001423 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698968001424 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 698968001425 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698968001426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968001427 Coenzyme A binding pocket [chemical binding]; other site 698968001428 UGMP family protein; Validated; Region: PRK09604 698968001429 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 698968001430 oligomerisation interface [polypeptide binding]; other site 698968001431 mobile loop; other site 698968001432 roof hairpin; other site 698968001433 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698968001434 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698968001435 ring oligomerisation interface [polypeptide binding]; other site 698968001436 ATP/Mg binding site [chemical binding]; other site 698968001437 stacking interactions; other site 698968001438 hinge regions; other site 698968001439 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 698968001440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968001441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968001442 DNA binding residues [nucleotide binding] 698968001443 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 698968001444 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698968001445 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 698968001446 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 698968001447 active site 698968001448 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 698968001449 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698968001450 phosphate binding site [ion binding]; other site 698968001451 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698968001452 siderophore binding site; other site 698968001453 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001454 dimer interface [polypeptide binding]; other site 698968001455 putative PBP binding regions; other site 698968001456 ABC-ATPase subunit interface; other site 698968001457 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698968001458 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001459 ABC-ATPase subunit interface; other site 698968001460 dimer interface [polypeptide binding]; other site 698968001461 putative PBP binding regions; other site 698968001462 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 698968001463 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968001464 Walker A/P-loop; other site 698968001465 ATP binding site [chemical binding]; other site 698968001466 Q-loop/lid; other site 698968001467 ABC transporter signature motif; other site 698968001468 Walker B; other site 698968001469 D-loop; other site 698968001470 H-loop/switch region; other site 698968001471 IucA / IucC family; Region: IucA_IucC; pfam04183 698968001472 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698968001473 IucA / IucC family; Region: IucA_IucC; pfam04183 698968001474 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 698968001475 H+ Antiporter protein; Region: 2A0121; TIGR00900 698968001476 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 698968001477 EamA-like transporter family; Region: EamA; cl01037 698968001478 GMP synthase; Reviewed; Region: guaA; PRK00074 698968001479 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 698968001480 AMP/PPi binding site [chemical binding]; other site 698968001481 candidate oxyanion hole; other site 698968001482 catalytic triad [active] 698968001483 potential glutamine specificity residues [chemical binding]; other site 698968001484 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 698968001485 ATP Binding subdomain [chemical binding]; other site 698968001486 Ligand Binding sites [chemical binding]; other site 698968001487 Dimerization subdomain; other site 698968001488 PspC domain; Region: PspC; cl00864 698968001489 PspC domain; Region: PspC; cl00864 698968001490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968001491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698968001492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968001493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968001494 active site 698968001495 phosphorylation site [posttranslational modification] 698968001496 intermolecular recognition site; other site 698968001497 dimerization interface [polypeptide binding]; other site 698968001498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968001499 DNA binding residues [nucleotide binding] 698968001500 dimerization interface [polypeptide binding]; other site 698968001501 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001502 intersubunit interface [polypeptide binding]; other site 698968001503 DNA Polymerase Y-family; Region: PolY_like; cd03468 698968001504 active site 698968001505 DNA binding site [nucleotide binding] 698968001506 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 698968001507 putative dimer interface [polypeptide binding]; other site 698968001508 putative [2Fe-2S] cluster binding site [ion binding]; other site 698968001509 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698968001510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968001512 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 698968001513 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 698968001514 Walker A/P-loop; other site 698968001515 ATP binding site [chemical binding]; other site 698968001516 Q-loop/lid; other site 698968001517 ABC transporter signature motif; other site 698968001518 Walker B; other site 698968001519 D-loop; other site 698968001520 H-loop/switch region; other site 698968001521 NIL domain; Region: NIL; cl09633 698968001522 NMT1-like family; Region: NMT1_2; cl15260 698968001523 NMT1-like family; Region: NMT1_2; cl15260 698968001524 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 698968001525 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 698968001526 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698968001527 generic binding surface II; other site 698968001528 generic binding surface I; other site 698968001529 Bacterial PH domain; Region: DUF304; cl01348 698968001530 Predicted membrane protein [Function unknown]; Region: COG3428 698968001531 Bacterial PH domain; Region: DUF304; cl01348 698968001532 Bacterial PH domain; Region: DUF304; cl01348 698968001533 Bacterial PH domain; Region: DUF304; cl01348 698968001534 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001535 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 698968001536 intersubunit interface [polypeptide binding]; other site 698968001537 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698968001538 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 698968001539 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698968001540 dimer interface [polypeptide binding]; other site 698968001541 putative PBP binding regions; other site 698968001542 ABC-ATPase subunit interface; other site 698968001543 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698968001544 ABC-ATPase subunit interface; other site 698968001545 dimer interface [polypeptide binding]; other site 698968001546 putative PBP binding regions; other site 698968001547 Helix-turn-helix domains; Region: HTH; cl00088 698968001548 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698968001549 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698968001550 FeoA domain; Region: FeoA; cl00838 698968001551 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 698968001552 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 698968001553 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 698968001554 homodimer interface [polypeptide binding]; other site 698968001555 NADP binding site [chemical binding]; other site 698968001556 substrate binding site [chemical binding]; other site 698968001557 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 698968001558 Helix-turn-helix domains; Region: HTH; cl00088 698968001559 Helix-turn-helix domains; Region: HTH; cl00088 698968001560 putative transposase OrfB; Reviewed; Region: PHA02517 698968001561 HTH-like domain; Region: HTH_21; pfam13276 698968001562 Integrase core domain; Region: rve; cl01316 698968001563 Integrase core domain; Region: rve_3; cl15866 698968001564 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968001565 active site 698968001566 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968001567 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 698968001568 Htaa; Region: HtaA; pfam04213 698968001569 Htaa; Region: HtaA; pfam04213 698968001570 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 698968001571 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 698968001572 intersubunit interface [polypeptide binding]; other site 698968001573 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968001574 ABC-ATPase subunit interface; other site 698968001575 dimer interface [polypeptide binding]; other site 698968001576 putative PBP binding regions; other site 698968001577 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 698968001578 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968001579 Walker A/P-loop; other site 698968001580 ATP binding site [chemical binding]; other site 698968001581 Q-loop/lid; other site 698968001582 ABC transporter signature motif; other site 698968001583 Walker B; other site 698968001584 D-loop; other site 698968001585 H-loop/switch region; other site 698968001586 Htaa; Region: HtaA; pfam04213 698968001587 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 698968001588 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 698968001589 homodimer interface [polypeptide binding]; other site 698968001590 substrate-cofactor binding pocket; other site 698968001591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968001592 catalytic residue [active] 698968001593 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 698968001594 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698968001595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968001596 putative substrate translocation pore; other site 698968001597 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698968001598 putative catalytic site [active] 698968001599 putative metal binding site [ion binding]; other site 698968001600 putative phosphate binding site [ion binding]; other site 698968001601 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 698968001602 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 698968001603 active site 698968001604 HIGH motif; other site 698968001605 dimer interface [polypeptide binding]; other site 698968001606 KMSKS motif; other site 698968001607 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 698968001608 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 698968001609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968001610 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698968001611 NlpC/P60 family; Region: NLPC_P60; cl11438 698968001612 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968001613 active site 698968001614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968001615 non-specific DNA binding site [nucleotide binding]; other site 698968001616 salt bridge; other site 698968001617 sequence-specific DNA binding site [nucleotide binding]; other site 698968001618 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698968001619 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 698968001620 metal binding site [ion binding]; metal-binding site 698968001621 putative dimer interface [polypeptide binding]; other site 698968001622 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 698968001623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968001624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968001625 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968001626 pyruvate carboxylase; Reviewed; Region: PRK12999 698968001627 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968001628 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968001629 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 698968001630 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698968001631 active site 698968001632 catalytic residues [active] 698968001633 metal binding site [ion binding]; metal-binding site 698968001634 homodimer binding site [polypeptide binding]; other site 698968001635 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968001636 carboxyltransferase (CT) interaction site; other site 698968001637 biotinylation site [posttranslational modification]; other site 698968001638 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 698968001639 ADP-ribose binding site [chemical binding]; other site 698968001640 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 698968001641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968001642 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968001643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 698968001644 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968001645 carboxyltransferase (CT) interaction site; other site 698968001646 biotinylation site [posttranslational modification]; other site 698968001647 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698968001648 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698968001649 active site residue [active] 698968001650 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698968001651 active site residue [active] 698968001652 OpgC protein; Region: OpgC_C; cl00792 698968001653 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 698968001654 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 698968001655 active site 698968001656 dimer interface [polypeptide binding]; other site 698968001657 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 698968001658 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 698968001659 substrate binding site [chemical binding]; other site 698968001660 dimer interface [polypeptide binding]; other site 698968001661 ATP binding site [chemical binding]; other site 698968001662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698968001663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698968001664 DNA binding site [nucleotide binding] 698968001665 domain linker motif; other site 698968001666 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 698968001667 dimerization interface [polypeptide binding]; other site 698968001668 putative ligand binding site [chemical binding]; other site 698968001669 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 698968001670 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698968001671 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001672 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001673 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698968001674 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001675 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001676 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 698968001677 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698968001678 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 698968001679 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968001680 AIR carboxylase; Region: AIRC; cl00310 698968001681 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698968001682 putative active site [active] 698968001683 Hydrogenase formation hypA family; Region: HypD; cl12072 698968001684 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 698968001685 HupF/HypC family; Region: HupF_HypC; cl00394 698968001686 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 698968001687 dimerization interface [polypeptide binding]; other site 698968001688 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 698968001689 ATP binding site [chemical binding]; other site 698968001690 Acylphosphatase; Region: Acylphosphatase; cl00551 698968001691 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 698968001692 HypF finger; Region: zf-HYPF; pfam07503 698968001693 HypF finger; Region: zf-HYPF; pfam07503 698968001694 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 698968001695 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 698968001696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001697 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001698 G4 box; other site 698968001699 G5 box; other site 698968001700 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 698968001701 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 698968001702 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 698968001703 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698968001704 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 698968001705 putative substrate-binding site; other site 698968001706 nickel binding site [ion binding]; other site 698968001707 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 698968001708 hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418 698968001709 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 698968001710 AMP-binding enzyme; Region: AMP-binding; cl15778 698968001711 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698968001712 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698968001713 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 698968001714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968001715 active site 698968001716 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968001717 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 698968001718 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 698968001719 active site 698968001720 Substrate binding site; other site 698968001721 Mg++ binding site; other site 698968001722 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968001723 putative trimer interface [polypeptide binding]; other site 698968001724 putative CoA binding site [chemical binding]; other site 698968001725 Transcription factor WhiB; Region: Whib; pfam02467 698968001726 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 698968001727 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 698968001728 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 698968001729 active site 698968001730 substrate binding site [chemical binding]; other site 698968001731 metal binding site [ion binding]; metal-binding site 698968001732 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 698968001733 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 698968001734 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 698968001735 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 698968001736 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 698968001737 oligomerization interface [polypeptide binding]; other site 698968001738 active site 698968001739 NAD+ binding site [chemical binding]; other site 698968001740 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 698968001741 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 698968001742 TMP-binding site; other site 698968001743 ATP-binding site [chemical binding]; other site 698968001744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968001746 active site 698968001747 phosphorylation site [posttranslational modification] 698968001748 intermolecular recognition site; other site 698968001749 dimerization interface [polypeptide binding]; other site 698968001750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968001751 DNA binding site [nucleotide binding] 698968001752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968001753 dimerization interface [polypeptide binding]; other site 698968001754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968001755 dimer interface [polypeptide binding]; other site 698968001756 phosphorylation site [posttranslational modification] 698968001757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968001758 ATP binding site [chemical binding]; other site 698968001759 Mg2+ binding site [ion binding]; other site 698968001760 G-X-G motif; other site 698968001761 lipoprotein LpqB; Provisional; Region: PRK13616 698968001762 Sporulation and spore germination; Region: Germane; cl11253 698968001763 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 698968001764 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968001765 active site 698968001766 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 698968001767 30S subunit binding site; other site 698968001768 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 698968001769 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 698968001770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968001771 nucleotide binding region [chemical binding]; other site 698968001772 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698968001773 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 698968001774 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 698968001775 FAD binding pocket [chemical binding]; other site 698968001776 FAD binding motif [chemical binding]; other site 698968001777 phosphate binding motif [ion binding]; other site 698968001778 beta-alpha-beta structure motif; other site 698968001779 NAD binding pocket [chemical binding]; other site 698968001780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 698968001781 catalytic loop [active] 698968001782 iron binding site [ion binding]; other site 698968001783 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 698968001784 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 698968001785 putative di-iron ligands [ion binding]; other site 698968001786 Predicted GTPases [General function prediction only]; Region: COG1162 698968001787 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 698968001788 GTPase/Zn-binding domain interface [polypeptide binding]; other site 698968001789 GTP/Mg2+ binding site [chemical binding]; other site 698968001790 G4 box; other site 698968001791 G5 box; other site 698968001792 G1 box; other site 698968001793 Switch I region; other site 698968001794 G2 box; other site 698968001795 G3 box; other site 698968001796 Switch II region; other site 698968001797 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 698968001798 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 698968001799 hinge; other site 698968001800 active site 698968001801 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 698968001802 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 698968001803 putative deacylase active site [active] 698968001804 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 698968001805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968001806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968001807 DNA binding residues [nucleotide binding] 698968001808 Transcription factor WhiB; Region: Whib; pfam02467 698968001809 PQQ-like domain; Region: PQQ_2; pfam13360 698968001810 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698968001811 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698968001812 ATP binding site [chemical binding]; other site 698968001813 Mg++ binding site [ion binding]; other site 698968001814 motif III; other site 698968001815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968001816 nucleotide binding region [chemical binding]; other site 698968001817 ATP-binding site [chemical binding]; other site 698968001818 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 698968001819 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 698968001820 TIGR02569 family protein; Region: TIGR02569_actnb 698968001821 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698968001822 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968001823 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968001824 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698968001825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001826 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 698968001827 Family description; Region: UvrD_C_2; cl15862 698968001828 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968001829 Ion channel; Region: Ion_trans_2; cl11596 698968001830 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698968001831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968001832 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 698968001833 putative NADH binding site [chemical binding]; other site 698968001834 putative active site [active] 698968001835 nudix motif; other site 698968001836 putative metal binding site [ion binding]; other site 698968001837 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 698968001838 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001839 Family description; Region: UvrD_C_2; cl15862 698968001840 HRDC domain; Region: HRDC; cl02578 698968001841 Protein of unknown function DUF45; Region: DUF45; cl00636 698968001842 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 698968001843 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 698968001844 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698968001845 protein binding site [polypeptide binding]; other site 698968001846 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 698968001847 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 698968001848 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698968001849 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698968001850 active site 698968001851 Protein of unknown function (DUF418); Region: DUF418; cl12135 698968001852 oxaloacetate decarboxylase; Provisional; Region: PRK12330 698968001853 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 698968001854 active site 698968001855 catalytic residues [active] 698968001856 metal binding site [ion binding]; metal-binding site 698968001857 homodimer binding site [polypeptide binding]; other site 698968001858 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 698968001859 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001860 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001861 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968001862 carboxyltransferase (CT) interaction site; other site 698968001863 biotinylation site [posttranslational modification]; other site 698968001864 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 698968001865 active site 698968001866 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698968001867 active site 698968001868 peptide chain release factor 2; Validated; Region: prfB; PRK00578 698968001869 RF-1 domain; Region: RF-1; cl02875 698968001870 RF-1 domain; Region: RF-1; cl02875 698968001871 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 698968001872 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 698968001873 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 698968001874 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968001875 Walker A/P-loop; other site 698968001876 ATP binding site [chemical binding]; other site 698968001877 Q-loop/lid; other site 698968001878 ABC transporter signature motif; other site 698968001879 Walker B; other site 698968001880 D-loop; other site 698968001881 H-loop/switch region; other site 698968001882 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 698968001883 FtsX-like permease family; Region: FtsX; cl15850 698968001884 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 698968001885 SmpB-tmRNA interface; other site 698968001886 Helix-turn-helix domains; Region: HTH; cl00088 698968001887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698968001888 HTH-like domain; Region: HTH_21; pfam13276 698968001889 Integrase core domain; Region: rve; cl01316 698968001890 Integrase core domain; Region: rve_3; cl15866 698968001891 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968001892 MULE transposase domain; Region: MULE; pfam10551 698968001893 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 698968001894 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 698968001895 active site 698968001896 zinc binding site [ion binding]; other site 698968001897 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39F; cd02425 698968001898 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 698968001899 putative active site [active] 698968001900 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968001901 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 698968001902 Walker A/P-loop; other site 698968001903 ATP binding site [chemical binding]; other site 698968001904 Q-loop/lid; other site 698968001905 ABC transporter signature motif; other site 698968001906 Walker B; other site 698968001907 D-loop; other site 698968001908 H-loop/switch region; other site 698968001909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968001910 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 698968001911 Walker A/P-loop; other site 698968001912 ATP binding site [chemical binding]; other site 698968001913 Q-loop/lid; other site 698968001914 ABC transporter signature motif; other site 698968001915 Walker B; other site 698968001916 D-loop; other site 698968001917 H-loop/switch region; other site 698968001918 Integrase core domain; Region: rve_3; cl15866 698968001919 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968001920 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 698968001921 DNA-binding interface [nucleotide binding]; DNA binding site 698968001922 HTH-like domain; Region: HTH_21; pfam13276 698968001923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698968001924 Integrase core domain; Region: rve; cl01316 698968001925 Integrase core domain; Region: rve_3; cl15866 698968001926 Cupin domain; Region: Cupin_2; cl09118 698968001927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968001928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968001929 Integrase core domain; Region: rve_3; cl15866 698968001930 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698968001931 Helix-turn-helix domains; Region: HTH; cl00088 698968001932 Integrase core domain; Region: rve; cl01316 698968001933 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968001934 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968001935 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698968001936 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 698968001937 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698968001938 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968001939 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968001940 nucleotide binding region [chemical binding]; other site 698968001941 ATP-binding site [chemical binding]; other site 698968001942 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 698968001943 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698968001944 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 698968001945 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 698968001946 DNA-binding site [nucleotide binding]; DNA binding site 698968001947 RNA-binding motif; other site 698968001948 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 698968001949 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 698968001950 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 698968001951 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 698968001952 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968001953 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698968001954 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 698968001955 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968001956 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 698968001957 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968001958 catalytic residue [active] 698968001959 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 698968001960 dimer interface [polypeptide binding]; other site 698968001961 Citrate synthase; Region: Citrate_synt; pfam00285 698968001962 active site 698968001963 citrylCoA binding site [chemical binding]; other site 698968001964 NADH binding [chemical binding]; other site 698968001965 cationic pore residues; other site 698968001966 oxalacetate/citrate binding site [chemical binding]; other site 698968001967 coenzyme A binding site [chemical binding]; other site 698968001968 catalytic triad [active] 698968001969 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 698968001970 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 698968001971 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968001972 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698968001973 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 698968001974 active site 698968001975 catalytic tetrad [active] 698968001976 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 698968001977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698968001978 substrate binding site [chemical binding]; other site 698968001979 oxyanion hole (OAH) forming residues; other site 698968001980 trimer interface [polypeptide binding]; other site 698968001981 Protein of unknown function, DUF485; Region: DUF485; cl01231 698968001982 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698968001983 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 698968001984 Na binding site [ion binding]; other site 698968001985 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 698968001986 active site 698968001987 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698968001988 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698968001989 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 698968001990 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968001991 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968001992 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698968001993 catalytic residues [active] 698968001994 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 698968001995 folate binding site [chemical binding]; other site 698968001996 NADP+ binding site [chemical binding]; other site 698968001997 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 698968001998 dimerization interface [polypeptide binding]; other site 698968001999 active site 698968002000 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 698968002001 active site 698968002002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002003 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 698968002004 ATP binding site [chemical binding]; other site 698968002005 putative Mg++ binding site [ion binding]; other site 698968002006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002007 nucleotide binding region [chemical binding]; other site 698968002008 ATP-binding site [chemical binding]; other site 698968002009 DEAD/H associated; Region: DEAD_assoc; pfam08494 698968002010 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 698968002011 active site 698968002012 SUMO-1 interface [polypeptide binding]; other site 698968002013 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698968002014 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 698968002015 putative DNA binding site [nucleotide binding]; other site 698968002016 catalytic residue [active] 698968002017 putative H2TH interface [polypeptide binding]; other site 698968002018 putative catalytic residues [active] 698968002019 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698968002020 Predicted permease [General function prediction only]; Region: COG2985 698968002021 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 698968002022 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698968002023 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698968002024 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 698968002025 hypothetical protein; Provisional; Region: PRK11770 698968002026 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698968002027 Domain of unknown function (DUF307); Region: DUF307; pfam03733 698968002028 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 698968002029 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 698968002030 active site 698968002031 dimer interface [polypeptide binding]; other site 698968002032 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 698968002033 dimer interface [polypeptide binding]; other site 698968002034 active site 698968002035 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968002036 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 698968002037 tetramerization interface [polypeptide binding]; other site 698968002038 NAD(P) binding site [chemical binding]; other site 698968002039 catalytic residues [active] 698968002040 Chorismate mutase type II; Region: CM_2; cl00693 698968002041 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 698968002042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002043 Family description; Region: UvrD_C_2; cl15862 698968002044 Peptidase family M23; Region: Peptidase_M23; pfam01551 698968002045 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 698968002046 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 698968002047 active site 698968002048 substrate binding site [chemical binding]; other site 698968002049 cosubstrate binding site; other site 698968002050 catalytic site [active] 698968002051 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 698968002052 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 698968002053 purine monophosphate binding site [chemical binding]; other site 698968002054 dimer interface [polypeptide binding]; other site 698968002055 putative catalytic residues [active] 698968002056 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 698968002057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968002058 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 698968002059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002060 Helix-turn-helix domains; Region: HTH; cl00088 698968002061 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698968002062 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 698968002063 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 698968002064 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 698968002065 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 698968002066 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 698968002067 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 698968002068 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968002069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968002070 active site 698968002071 phosphorylation site [posttranslational modification] 698968002072 intermolecular recognition site; other site 698968002073 dimerization interface [polypeptide binding]; other site 698968002074 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968002075 DNA binding site [nucleotide binding] 698968002076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 698968002077 dimerization interface [polypeptide binding]; other site 698968002078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968002079 dimer interface [polypeptide binding]; other site 698968002080 phosphorylation site [posttranslational modification] 698968002081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968002082 ATP binding site [chemical binding]; other site 698968002083 Mg2+ binding site [ion binding]; other site 698968002084 G-X-G motif; other site 698968002085 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698968002086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 698968002087 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 698968002088 MPT binding site; other site 698968002089 trimer interface [polypeptide binding]; other site 698968002090 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 698968002091 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 698968002092 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 698968002093 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 698968002094 active site 698968002095 tetramer interface; other site 698968002096 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 698968002097 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 698968002098 dimer interface [polypeptide binding]; other site 698968002099 putative functional site; other site 698968002100 putative MPT binding site; other site 698968002101 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968002102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698968002103 DoxX; Region: DoxX; cl00976 698968002104 Predicted integral membrane protein [Function unknown]; Region: COG5660 698968002105 Putative zinc-finger; Region: zf-HC2; cl15806 698968002106 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 698968002107 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 698968002108 BCCT family transporter; Region: BCCT; cl00569 698968002109 Uncharacterized membrane protein [Function unknown]; Region: COG3949 698968002110 Predicted methyltransferases [General function prediction only]; Region: COG0313 698968002111 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968002112 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 698968002113 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 698968002114 active site 698968002115 HIGH motif; other site 698968002116 KMSKS motif; other site 698968002117 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 698968002118 tRNA binding surface [nucleotide binding]; other site 698968002119 anticodon binding site; other site 698968002120 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 698968002121 active site 698968002122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 698968002123 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698968002124 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698968002125 Domain of unknown function (DUF348); Region: DUF348; pfam03990 698968002126 G5 domain; Region: G5; pfam07501 698968002127 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698968002128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002129 S-adenosylmethionine binding site [chemical binding]; other site 698968002130 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 698968002131 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698968002132 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698968002133 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698968002134 ABC transporter; Region: ABC_tran_2; pfam12848 698968002135 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698968002136 Mnd1 family; Region: Mnd1; pfam03962 698968002137 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698968002138 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 698968002139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968002140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968002141 DNA binding residues [nucleotide binding] 698968002142 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 698968002143 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 698968002144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968002145 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698968002146 active site 698968002147 motif I; other site 698968002148 motif II; other site 698968002149 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698968002150 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 698968002151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 698968002152 substrate binding site [chemical binding]; other site 698968002153 oxyanion hole (OAH) forming residues; other site 698968002154 trimer interface [polypeptide binding]; other site 698968002155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 698968002156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002157 Helix-turn-helix domains; Region: HTH; cl00088 698968002158 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 698968002159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002160 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698968002161 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 698968002162 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 698968002163 G1 box; other site 698968002164 putative GEF interaction site [polypeptide binding]; other site 698968002165 GTP/Mg2+ binding site [chemical binding]; other site 698968002166 Switch I region; other site 698968002167 G2 box; other site 698968002168 G3 box; other site 698968002169 Switch II region; other site 698968002170 G4 box; other site 698968002171 G5 box; other site 698968002172 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 698968002173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002174 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 698968002175 NAD(P) binding site [chemical binding]; other site 698968002176 active site 698968002177 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698968002178 putative active site [active] 698968002179 catalytic residue [active] 698968002180 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968002181 active site 698968002182 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 698968002183 putative active site [active] 698968002184 catalytic residue [active] 698968002185 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 698968002186 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 698968002187 5S rRNA interface [nucleotide binding]; other site 698968002188 CTC domain interface [polypeptide binding]; other site 698968002189 L16 interface [polypeptide binding]; other site 698968002190 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 698968002191 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 698968002192 Ca binding site [ion binding]; other site 698968002193 active site 698968002194 catalytic site [active] 698968002195 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 698968002196 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 698968002197 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 698968002198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968002199 active site 698968002200 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 698968002201 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 698968002202 Substrate binding site; other site 698968002203 Mg++ binding site; other site 698968002204 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 698968002205 active site 698968002206 substrate binding site [chemical binding]; other site 698968002207 CoA binding site [chemical binding]; other site 698968002208 Helix-turn-helix domains; Region: HTH; cl00088 698968002209 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 698968002210 putative dimerization interface [polypeptide binding]; other site 698968002211 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 698968002212 gating phenylalanine in ion channel; other site 698968002213 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 698968002214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002215 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002216 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968002217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002218 Q-loop/lid; other site 698968002219 ABC transporter signature motif; other site 698968002220 Walker B; other site 698968002221 D-loop; other site 698968002222 H-loop/switch region; other site 698968002223 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002224 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968002225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002226 Walker A/P-loop; other site 698968002227 ATP binding site [chemical binding]; other site 698968002228 Q-loop/lid; other site 698968002229 ABC transporter signature motif; other site 698968002230 Walker B; other site 698968002231 D-loop; other site 698968002232 H-loop/switch region; other site 698968002233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002234 Helix-turn-helix domains; Region: HTH; cl00088 698968002235 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 698968002236 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 698968002237 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002238 ATP binding site [chemical binding]; other site 698968002239 putative Mg++ binding site [ion binding]; other site 698968002240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002241 nucleotide binding region [chemical binding]; other site 698968002242 ATP-binding site [chemical binding]; other site 698968002243 TRCF domain; Region: TRCF; cl04088 698968002244 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 698968002245 Spore germination protein; Region: Spore_permease; cl15802 698968002246 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 698968002247 enolase; Provisional; Region: eno; PRK00077 698968002248 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 698968002249 dimer interface [polypeptide binding]; other site 698968002250 metal binding site [ion binding]; metal-binding site 698968002251 substrate binding pocket [chemical binding]; other site 698968002252 Septum formation initiator; Region: DivIC; cl11433 698968002253 Protein of unknown function (DUF501); Region: DUF501; cl00652 698968002254 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 698968002255 Helix-turn-helix domain; Region: HTH_18; pfam12833 698968002256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 698968002257 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 698968002258 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 698968002259 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 698968002260 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 698968002261 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 698968002262 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698968002263 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 698968002264 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 698968002265 catalytic residue [active] 698968002266 putative FPP diphosphate binding site; other site 698968002267 putative FPP binding hydrophobic cleft; other site 698968002268 dimer interface [polypeptide binding]; other site 698968002269 putative IPP diphosphate binding site; other site 698968002270 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698968002271 pantothenate kinase; Provisional; Region: PRK05439 698968002272 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 698968002273 ATP-binding site [chemical binding]; other site 698968002274 CoA-binding site [chemical binding]; other site 698968002275 Mg2+-binding site [ion binding]; other site 698968002276 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 698968002277 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 698968002278 dimer interface [polypeptide binding]; other site 698968002279 active site 698968002280 glycine-pyridoxal phosphate binding site [chemical binding]; other site 698968002281 folate binding site [chemical binding]; other site 698968002282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 698968002283 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 698968002284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968002285 Coenzyme A binding pocket [chemical binding]; other site 698968002286 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 698968002287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002288 putative substrate translocation pore; other site 698968002289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968002291 Helix-turn-helix domains; Region: HTH; cl00088 698968002292 fumarate hydratase; Reviewed; Region: fumC; PRK00485 698968002293 Class II fumarases; Region: Fumarase_classII; cd01362 698968002294 active site 698968002295 tetramer interface [polypeptide binding]; other site 698968002296 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 698968002297 putative active site [active] 698968002298 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 698968002299 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 698968002300 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 698968002301 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 698968002302 generic binding surface II; other site 698968002303 generic binding surface I; other site 698968002304 LytB protein; Region: LYTB; cl00507 698968002305 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 698968002306 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 698968002307 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 698968002308 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 698968002309 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 698968002310 Na2 binding site [ion binding]; other site 698968002311 putative substrate binding site 1 [chemical binding]; other site 698968002312 Na binding site 1 [ion binding]; other site 698968002313 putative substrate binding site 2 [chemical binding]; other site 698968002314 GTP-binding protein YchF; Reviewed; Region: PRK09601 698968002315 YchF GTPase; Region: YchF; cd01900 698968002316 G1 box; other site 698968002317 GTP/Mg2+ binding site [chemical binding]; other site 698968002318 Switch I region; other site 698968002319 G2 box; other site 698968002320 Switch II region; other site 698968002321 G3 box; other site 698968002322 G4 box; other site 698968002323 G5 box; other site 698968002324 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 698968002325 Protein of unknown function (DUF808); Region: DUF808; cl01002 698968002326 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 698968002327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002328 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 698968002329 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 698968002330 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 698968002331 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 698968002332 Cl- selectivity filter; other site 698968002333 Cl- binding residues [ion binding]; other site 698968002334 pore gating glutamate residue; other site 698968002335 dimer interface [polypeptide binding]; other site 698968002336 Helix-turn-helix domains; Region: HTH; cl00088 698968002337 Helix-turn-helix domains; Region: HTH; cl00088 698968002338 putative transposase OrfB; Reviewed; Region: PHA02517 698968002339 HTH-like domain; Region: HTH_21; pfam13276 698968002340 Integrase core domain; Region: rve; cl01316 698968002341 Integrase core domain; Region: rve_3; cl15866 698968002342 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698968002343 Walker A/P-loop; other site 698968002344 ATP binding site [chemical binding]; other site 698968002345 ABC transporter; Region: ABC_tran; pfam00005 698968002346 Q-loop/lid; other site 698968002347 ABC transporter signature motif; other site 698968002348 Walker B; other site 698968002349 D-loop; other site 698968002350 H-loop/switch region; other site 698968002351 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 698968002352 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698968002353 Walker A/P-loop; other site 698968002354 ATP binding site [chemical binding]; other site 698968002355 Q-loop/lid; other site 698968002356 ABC transporter signature motif; other site 698968002357 Walker B; other site 698968002358 D-loop; other site 698968002359 H-loop/switch region; other site 698968002360 Cobalt transport protein; Region: CbiQ; cl00463 698968002361 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 698968002362 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 698968002363 active site 698968002364 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698968002365 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 698968002366 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698968002367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968002368 dimer interface [polypeptide binding]; other site 698968002369 conserved gate region; other site 698968002370 putative PBP binding loops; other site 698968002371 ABC-ATPase subunit interface; other site 698968002372 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698968002373 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968002374 Walker A/P-loop; other site 698968002375 ATP binding site [chemical binding]; other site 698968002376 Q-loop/lid; other site 698968002377 ABC transporter signature motif; other site 698968002378 Walker B; other site 698968002379 D-loop; other site 698968002380 H-loop/switch region; other site 698968002381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968002382 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968002383 Walker A/P-loop; other site 698968002384 ATP binding site [chemical binding]; other site 698968002385 Q-loop/lid; other site 698968002386 ABC transporter signature motif; other site 698968002387 Walker B; other site 698968002388 D-loop; other site 698968002389 H-loop/switch region; other site 698968002390 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968002391 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 698968002392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002393 Walker A/P-loop; other site 698968002394 ATP binding site [chemical binding]; other site 698968002395 ABC transporter signature motif; other site 698968002396 Walker B; other site 698968002397 D-loop; other site 698968002398 H-loop/switch region; other site 698968002399 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 698968002400 active site 698968002401 substrate binding sites [chemical binding]; other site 698968002402 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 698968002403 ArsC family; Region: ArsC; pfam03960 698968002404 catalytic residues [active] 698968002405 Protein of unknown function (DUF402); Region: DUF402; cl00979 698968002406 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002407 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 698968002408 G1 box; other site 698968002409 GTP/Mg2+ binding site [chemical binding]; other site 698968002410 G2 box; other site 698968002411 Switch I region; other site 698968002412 G3 box; other site 698968002413 Switch II region; other site 698968002414 G4 box; other site 698968002415 G5 box; other site 698968002416 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 698968002417 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 698968002418 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 698968002419 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 698968002420 Ferredoxin [Energy production and conversion]; Region: COG1146 698968002421 4Fe-4S binding domain; Region: Fer4; cl02805 698968002422 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 698968002423 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968002424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968002425 homodimer interface [polypeptide binding]; other site 698968002426 catalytic residue [active] 698968002427 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 698968002428 active site 698968002429 GtrA-like protein; Region: GtrA; cl00971 698968002430 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968002431 active site 698968002432 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698968002433 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 698968002434 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698968002435 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 698968002436 putative trimer interface [polypeptide binding]; other site 698968002437 putative CoA binding site [chemical binding]; other site 698968002438 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 698968002439 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 698968002440 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 698968002441 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968002442 putative trimer interface [polypeptide binding]; other site 698968002443 putative CoA binding site [chemical binding]; other site 698968002444 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 698968002445 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 698968002446 metal binding site [ion binding]; metal-binding site 698968002447 putative dimer interface [polypeptide binding]; other site 698968002448 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 698968002449 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698968002450 dihydropteroate synthase; Region: DHPS; TIGR01496 698968002451 substrate binding pocket [chemical binding]; other site 698968002452 dimer interface [polypeptide binding]; other site 698968002453 inhibitor binding site; inhibition site 698968002454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968002455 active site 698968002456 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 698968002457 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 698968002458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968002459 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 698968002460 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 698968002461 active site 698968002462 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 698968002463 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 698968002464 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 698968002465 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968002466 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 698968002467 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 698968002468 ligand binding site; other site 698968002469 oligomer interface; other site 698968002470 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 698968002471 dimer interface [polypeptide binding]; other site 698968002472 N-terminal domain interface [polypeptide binding]; other site 698968002473 sulfate 1 binding site; other site 698968002474 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 698968002475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968002476 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 698968002477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968002478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968002479 DNA binding residues [nucleotide binding] 698968002480 Putative zinc-finger; Region: zf-HC2; cl15806 698968002481 sec-independent translocase; Provisional; Region: tatB; PRK00182 698968002482 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698968002483 Domain of unknown function DUF59; Region: DUF59; cl00941 698968002484 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 698968002485 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 698968002486 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 698968002487 MgtE intracellular N domain; Region: MgtE_N; cl15244 698968002488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 698968002489 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 698968002490 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 698968002491 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 698968002492 TPP-binding site [chemical binding]; other site 698968002493 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 698968002494 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002495 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968002496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002497 Walker A/P-loop; other site 698968002498 ATP binding site [chemical binding]; other site 698968002499 Q-loop/lid; other site 698968002500 ABC transporter signature motif; other site 698968002501 Walker B; other site 698968002502 D-loop; other site 698968002503 H-loop/switch region; other site 698968002504 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968002505 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968002506 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002507 Walker A/P-loop; other site 698968002508 ATP binding site [chemical binding]; other site 698968002509 Q-loop/lid; other site 698968002510 ABC transporter signature motif; other site 698968002511 Walker B; other site 698968002512 D-loop; other site 698968002513 H-loop/switch region; other site 698968002514 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 698968002515 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698968002516 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698968002517 shikimate binding site; other site 698968002518 NAD(P) binding site [chemical binding]; other site 698968002519 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968002520 catalytic triad [active] 698968002521 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 698968002522 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 698968002523 active site 698968002524 catalytic residues [active] 698968002525 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 698968002526 putative transporter; Provisional; Region: PRK10484 698968002527 Na binding site [ion binding]; other site 698968002528 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698968002529 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698968002530 nucleotide binding site/active site [active] 698968002531 HIT family signature motif; other site 698968002532 catalytic residue [active] 698968002533 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698968002534 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698968002535 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 698968002536 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 698968002537 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 698968002538 PLD-like domain; Region: PLDc_2; pfam13091 698968002539 putative homodimer interface [polypeptide binding]; other site 698968002540 putative active site [active] 698968002541 catalytic site [active] 698968002542 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968002543 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002545 nucleotide binding region [chemical binding]; other site 698968002546 ATP-binding site [chemical binding]; other site 698968002547 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 698968002548 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 698968002549 active site 698968002550 8-oxo-dGMP binding site [chemical binding]; other site 698968002551 nudix motif; other site 698968002552 metal binding site [ion binding]; metal-binding site 698968002553 helicase 45; Provisional; Region: PTZ00424 698968002554 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698968002555 ATP binding site [chemical binding]; other site 698968002556 Mg++ binding site [ion binding]; other site 698968002557 motif III; other site 698968002558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002559 nucleotide binding region [chemical binding]; other site 698968002560 ATP-binding site [chemical binding]; other site 698968002561 DbpA RNA binding domain; Region: DbpA; pfam03880 698968002562 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 698968002563 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 698968002564 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 698968002565 Na binding site [ion binding]; other site 698968002566 SNF2 Helicase protein; Region: DUF3670; pfam12419 698968002567 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 698968002568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002569 ATP binding site [chemical binding]; other site 698968002570 putative Mg++ binding site [ion binding]; other site 698968002571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002572 nucleotide binding region [chemical binding]; other site 698968002573 ATP-binding site [chemical binding]; other site 698968002574 SWIM zinc finger; Region: SWIM; cl15408 698968002575 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 698968002576 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 698968002577 active site 698968002578 metal binding site [ion binding]; metal-binding site 698968002579 DNA binding site [nucleotide binding] 698968002580 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 698968002581 YceI-like domain; Region: YceI; cl01001 698968002582 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698968002583 Helix-turn-helix domains; Region: HTH; cl00088 698968002584 PspC domain; Region: PspC; cl00864 698968002585 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 698968002586 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 698968002587 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 698968002588 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 698968002589 Cysteine-rich domain; Region: CCG; pfam02754 698968002590 Cysteine-rich domain; Region: CCG; pfam02754 698968002591 glycolate transporter; Provisional; Region: PRK09695 698968002592 L-lactate permease; Region: Lactate_perm; cl00701 698968002593 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 698968002594 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 698968002595 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 698968002596 active site 698968002597 HIGH motif; other site 698968002598 KMSK motif region; other site 698968002599 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 698968002600 tRNA binding surface [nucleotide binding]; other site 698968002601 anticodon binding site; other site 698968002602 diaminopimelate decarboxylase; Region: lysA; TIGR01048 698968002603 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 698968002604 active site 698968002605 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 698968002606 substrate binding site [chemical binding]; other site 698968002607 catalytic residues [active] 698968002608 dimer interface [polypeptide binding]; other site 698968002609 homoserine dehydrogenase; Provisional; Region: PRK06349 698968002610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002611 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 698968002612 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 698968002613 homoserine kinase; Provisional; Region: PRK01212 698968002614 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 698968002615 AMP-binding enzyme; Region: AMP-binding; cl15778 698968002616 transcription termination factor Rho; Provisional; Region: PRK12678 698968002617 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 698968002618 transcription termination factor Rho; Provisional; Region: PRK12608 698968002619 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698968002620 RNA binding site [nucleotide binding]; other site 698968002621 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 698968002622 multimer interface [polypeptide binding]; other site 698968002623 Walker A motif; other site 698968002624 ATP binding site [chemical binding]; other site 698968002625 Walker B motif; other site 698968002626 peptide chain release factor 1; Validated; Region: prfA; PRK00591 698968002627 RF-1 domain; Region: RF-1; cl02875 698968002628 RF-1 domain; Region: RF-1; cl02875 698968002629 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 698968002630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002631 S-adenosylmethionine binding site [chemical binding]; other site 698968002632 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 698968002633 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 698968002634 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 698968002635 Mg++ binding site [ion binding]; other site 698968002636 putative catalytic motif [active] 698968002637 substrate binding site [chemical binding]; other site 698968002638 ATP synthase A chain; Region: ATP-synt_A; cl00413 698968002639 ATP synthase subunit C; Region: ATP-synt_C; cl00466 698968002640 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 698968002641 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 698968002642 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 698968002643 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 698968002644 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 698968002645 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 698968002646 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 698968002647 beta subunit interaction interface [polypeptide binding]; other site 698968002648 Walker A motif; other site 698968002649 ATP binding site [chemical binding]; other site 698968002650 Walker B motif; other site 698968002651 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698968002652 ATP synthase; Region: ATP-synt; cl00365 698968002653 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 698968002654 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 698968002655 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 698968002656 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 698968002657 alpha subunit interaction interface [polypeptide binding]; other site 698968002658 Walker A motif; other site 698968002659 ATP binding site [chemical binding]; other site 698968002660 Walker B motif; other site 698968002661 inhibitor binding site; inhibition site 698968002662 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 698968002663 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 698968002664 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 698968002665 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 698968002666 Protein of unknown function DUF91; Region: DUF91; cl00709 698968002667 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 698968002668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 698968002669 dimer interface [polypeptide binding]; other site 698968002670 substrate binding site [chemical binding]; other site 698968002671 metal binding site [ion binding]; metal-binding site 698968002672 Domain of unknown function DUF77; Region: DUF77; cl00307 698968002673 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968002674 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 698968002675 Walker A/P-loop; other site 698968002676 ATP binding site [chemical binding]; other site 698968002677 Q-loop/lid; other site 698968002678 ABC transporter signature motif; other site 698968002679 Walker B; other site 698968002680 D-loop; other site 698968002681 H-loop/switch region; other site 698968002682 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698968002683 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968002684 ABC-ATPase subunit interface; other site 698968002685 dimer interface [polypeptide binding]; other site 698968002686 putative PBP binding regions; other site 698968002687 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968002688 ABC-ATPase subunit interface; other site 698968002689 dimer interface [polypeptide binding]; other site 698968002690 putative PBP binding regions; other site 698968002691 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 698968002692 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 698968002693 siderophore binding site; other site 698968002694 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 698968002695 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 698968002696 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 698968002697 PsiA protein; Region: PsiA; cl11646 698968002698 glycogen branching enzyme; Provisional; Region: PRK05402 698968002699 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 698968002700 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 698968002701 active site 698968002702 catalytic site [active] 698968002703 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 698968002704 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 698968002705 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 698968002706 active site 698968002707 homodimer interface [polypeptide binding]; other site 698968002708 catalytic site [active] 698968002709 acceptor binding site [chemical binding]; other site 698968002710 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968002711 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002712 Walker A/P-loop; other site 698968002713 ATP binding site [chemical binding]; other site 698968002714 Q-loop/lid; other site 698968002715 ABC transporter signature motif; other site 698968002716 Walker B; other site 698968002717 D-loop; other site 698968002718 H-loop/switch region; other site 698968002719 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 698968002720 Ligand binding site [chemical binding]; other site 698968002721 Electron transfer flavoprotein domain; Region: ETF; pfam01012 698968002722 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 698968002723 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 698968002724 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 698968002725 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 698968002726 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968002727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968002728 catalytic residue [active] 698968002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002730 S-adenosylmethionine binding site [chemical binding]; other site 698968002731 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 698968002732 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698968002733 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 698968002734 active site 698968002735 catalytic site [active] 698968002736 substrate binding site [chemical binding]; other site 698968002737 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 698968002738 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 698968002739 nucleotide binding pocket [chemical binding]; other site 698968002740 K-X-D-G motif; other site 698968002741 catalytic site [active] 698968002742 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 698968002743 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 698968002744 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 698968002745 Dimer interface [polypeptide binding]; other site 698968002746 BRCT sequence motif; other site 698968002747 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 698968002748 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 698968002749 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 698968002750 Amidase; Region: Amidase; cl11426 698968002751 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 698968002752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 698968002753 Coenzyme A binding pocket [chemical binding]; other site 698968002754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968002756 putative substrate translocation pore; other site 698968002757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968002758 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 698968002759 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 698968002760 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 698968002761 ABC-ATPase subunit interface; other site 698968002762 dimer interface [polypeptide binding]; other site 698968002763 putative PBP binding regions; other site 698968002764 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 698968002765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968002766 Walker A/P-loop; other site 698968002767 ATP binding site [chemical binding]; other site 698968002768 Q-loop/lid; other site 698968002769 ABC transporter signature motif; other site 698968002770 Walker B; other site 698968002771 H-loop/switch region; other site 698968002772 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 698968002773 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 698968002774 putative ligand binding residues [chemical binding]; other site 698968002775 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 698968002776 active site 698968002777 ADP/pyrophosphate binding site [chemical binding]; other site 698968002778 dimerization interface [polypeptide binding]; other site 698968002779 allosteric effector site; other site 698968002780 fructose-1,6-bisphosphate binding site; other site 698968002781 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 698968002782 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 698968002783 GatB domain; Region: GatB_Yqey; cl11497 698968002784 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 698968002785 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 698968002786 active site 698968002787 catalytic tetrad [active] 698968002788 LysE type translocator; Region: LysE; cl00565 698968002789 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 698968002790 Helix-turn-helix domains; Region: HTH; cl00088 698968002791 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 698968002792 dimerization interface [polypeptide binding]; other site 698968002793 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 698968002794 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698968002795 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 698968002796 putative dimer interface [polypeptide binding]; other site 698968002797 N-terminal domain interface [polypeptide binding]; other site 698968002798 putative substrate binding pocket (H-site) [chemical binding]; other site 698968002799 Protein of unknown function DUF262; Region: DUF262; cl14890 698968002800 DoxX; Region: DoxX; cl00976 698968002801 Dehydratase family; Region: ILVD_EDD; cl00340 698968002802 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698968002803 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 698968002804 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 698968002805 PYR/PP interface [polypeptide binding]; other site 698968002806 dimer interface [polypeptide binding]; other site 698968002807 TPP binding site [chemical binding]; other site 698968002808 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 698968002809 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 698968002810 TPP-binding site [chemical binding]; other site 698968002811 dimer interface [polypeptide binding]; other site 698968002812 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 698968002813 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 698968002814 putative valine binding site [chemical binding]; other site 698968002815 dimer interface [polypeptide binding]; other site 698968002816 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 698968002817 ketol-acid reductoisomerase; Provisional; Region: PRK05479 698968002818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002819 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 698968002820 Cation efflux family; Region: Cation_efflux; cl00316 698968002821 Protein of unknown function DUF262; Region: DUF262; cl14890 698968002822 Protein of unknown function DUF262; Region: DUF262; cl14890 698968002823 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 698968002824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002825 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 698968002826 putative L-serine binding site [chemical binding]; other site 698968002827 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 698968002828 tartrate dehydrogenase; Provisional; Region: PRK08194 698968002829 potential frameshift: common BLAST hit: gi|62390174|ref|YP_225576.1| signal transduction protein 698968002830 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 698968002831 ligand binding site [chemical binding]; other site 698968002832 flexible hinge region; other site 698968002833 FOG: CBS domain [General function prediction only]; Region: COG0517 698968002834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 698968002835 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968002836 metal binding triad; other site 698968002837 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 698968002838 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698968002839 catalytic site [active] 698968002840 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 698968002841 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 698968002842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002843 S-adenosylmethionine binding site [chemical binding]; other site 698968002844 isochorismate synthase DhbC; Validated; Region: PRK06923 698968002845 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698968002846 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 698968002847 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698968002848 active site 698968002849 HIGH motif; other site 698968002850 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 698968002851 active site 698968002852 KMSKS motif; other site 698968002853 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 698968002854 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968002855 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 698968002856 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 698968002857 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 698968002858 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 698968002859 PhnA protein; Region: PhnA; pfam03831 698968002860 biotin synthase; Region: bioB; TIGR00433 698968002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968002862 FeS/SAM binding site; other site 698968002863 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 698968002864 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698968002865 Transcriptional regulator [Transcription]; Region: IclR; COG1414 698968002866 Helix-turn-helix domains; Region: HTH; cl00088 698968002867 Bacterial transcriptional regulator; Region: IclR; pfam01614 698968002868 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 698968002869 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 698968002870 substrate binding site [chemical binding]; other site 698968002871 ligand binding site [chemical binding]; other site 698968002872 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 698968002873 substrate binding site [chemical binding]; other site 698968002874 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698968002875 active site 698968002876 Ap6A binding site [chemical binding]; other site 698968002877 nudix motif; other site 698968002878 metal binding site [ion binding]; metal-binding site 698968002879 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968002880 catalytic core [active] 698968002881 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 698968002882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968002883 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 698968002884 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 698968002885 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 698968002886 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968002887 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698968002888 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 698968002889 thiamine monophosphate kinase; Provisional; Region: PRK05731 698968002890 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 698968002891 ATP binding site [chemical binding]; other site 698968002892 dimerization interface [polypeptide binding]; other site 698968002893 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 698968002894 ligand binding site [chemical binding]; other site 698968002895 active site 698968002896 UGI interface [polypeptide binding]; other site 698968002897 catalytic site [active] 698968002898 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 698968002899 DAK2 domain; Region: Dak2; cl03685 698968002900 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 698968002901 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 698968002902 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 698968002903 generic binding surface II; other site 698968002904 ssDNA binding site; other site 698968002905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002906 ATP binding site [chemical binding]; other site 698968002907 putative Mg++ binding site [ion binding]; other site 698968002908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002909 nucleotide binding region [chemical binding]; other site 698968002910 ATP-binding site [chemical binding]; other site 698968002911 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 698968002912 carboxyltransferase (CT) interaction site; other site 698968002913 biotinylation site [posttranslational modification]; other site 698968002914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002915 S-adenosylmethionine binding site [chemical binding]; other site 698968002916 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 698968002917 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 698968002918 active site 698968002919 (T/H)XGH motif; other site 698968002920 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 698968002921 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 698968002922 Walker A/P-loop; other site 698968002923 ATP binding site [chemical binding]; other site 698968002924 Q-loop/lid; other site 698968002925 ABC transporter signature motif; other site 698968002926 Walker B; other site 698968002927 D-loop; other site 698968002928 H-loop/switch region; other site 698968002929 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968002930 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 698968002931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968002932 dimer interface [polypeptide binding]; other site 698968002933 conserved gate region; other site 698968002934 putative PBP binding loops; other site 698968002935 ABC-ATPase subunit interface; other site 698968002936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698968002937 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698968002938 substrate binding pocket [chemical binding]; other site 698968002939 membrane-bound complex binding site; other site 698968002940 hinge residues; other site 698968002941 Domain of unknown function (DUF368); Region: DUF368; cl00893 698968002942 DNA polymerase I; Provisional; Region: PRK05755 698968002943 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 698968002944 active site 698968002945 metal binding site 1 [ion binding]; metal-binding site 698968002946 putative 5' ssDNA interaction site; other site 698968002947 metal binding site 3; metal-binding site 698968002948 metal binding site 2 [ion binding]; metal-binding site 698968002949 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 698968002950 putative DNA binding site [nucleotide binding]; other site 698968002951 putative metal binding site [ion binding]; other site 698968002952 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 698968002953 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 698968002954 active site 698968002955 DNA binding site [nucleotide binding] 698968002956 catalytic site [active] 698968002957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968002958 S-adenosylmethionine binding site [chemical binding]; other site 698968002959 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 698968002960 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 698968002961 RNA binding site [nucleotide binding]; other site 698968002962 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 698968002963 RNA binding site [nucleotide binding]; other site 698968002964 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698968002965 RNA binding site [nucleotide binding]; other site 698968002966 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 698968002967 RNA binding site [nucleotide binding]; other site 698968002968 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 698968002969 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 698968002970 transcriptional antiterminator BglG; Provisional; Region: PRK09772 698968002971 CAT RNA binding domain; Region: CAT_RBD; cl03904 698968002972 PRD domain; Region: PRD; cl15445 698968002973 PRD domain; Region: PRD; cl15445 698968002974 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 698968002975 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 698968002976 active site turn [active] 698968002977 phosphorylation site [posttranslational modification] 698968002978 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 698968002979 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 698968002980 HPr interaction site; other site 698968002981 glycerol kinase (GK) interaction site [polypeptide binding]; other site 698968002982 active site 698968002983 phosphorylation site [posttranslational modification] 698968002984 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 698968002985 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 698968002986 CoA-binding site [chemical binding]; other site 698968002987 ATP-binding [chemical binding]; other site 698968002988 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 698968002989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968002990 FeS/SAM binding site; other site 698968002991 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 698968002992 excinuclease ABC subunit B; Provisional; Region: PRK05298 698968002993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968002994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968002995 nucleotide binding region [chemical binding]; other site 698968002996 ATP-binding site [chemical binding]; other site 698968002997 Ultra-violet resistance protein B; Region: UvrB; pfam12344 698968002998 UvrB/uvrC motif; Region: UVR; pfam02151 698968002999 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968003000 Ligand Binding Site [chemical binding]; other site 698968003001 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 698968003002 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003003 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003004 Family description; Region: UvrD_C_2; cl15862 698968003005 DoxX; Region: DoxX; cl00976 698968003006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698968003007 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 698968003008 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 698968003009 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 698968003010 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 698968003011 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 698968003012 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 698968003013 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 698968003014 ribosomal protein L20; Region: rpl20; CHL00068 698968003015 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 698968003016 23S rRNA binding site [nucleotide binding]; other site 698968003017 L21 binding site [polypeptide binding]; other site 698968003018 L13 binding site [polypeptide binding]; other site 698968003019 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968003020 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 698968003021 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698968003022 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 698968003023 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 698968003024 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 698968003025 dimer interface [polypeptide binding]; other site 698968003026 motif 1; other site 698968003027 active site 698968003028 motif 2; other site 698968003029 motif 3; other site 698968003030 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 698968003031 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 698968003032 putative tRNA-binding site [nucleotide binding]; other site 698968003033 B3/4 domain; Region: B3_4; cl11458 698968003034 tRNA synthetase B5 domain; Region: B5; cl08394 698968003035 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 698968003036 dimer interface [polypeptide binding]; other site 698968003037 motif 1; other site 698968003038 motif 3; other site 698968003039 motif 2; other site 698968003040 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 698968003041 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 698968003042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003043 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698968003044 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 698968003045 heterotetramer interface [polypeptide binding]; other site 698968003046 active site pocket [active] 698968003047 cleavage site 698968003048 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 698968003049 feedback inhibition sensing region; other site 698968003050 homohexameric interface [polypeptide binding]; other site 698968003051 nucleotide binding site [chemical binding]; other site 698968003052 N-acetyl-L-glutamate binding site [chemical binding]; other site 698968003053 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 698968003054 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698968003055 inhibitor-cofactor binding pocket; inhibition site 698968003056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968003057 catalytic residue [active] 698968003058 ornithine carbamoyltransferase; Provisional; Region: PRK00779 698968003059 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698968003060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003061 arginine repressor; Provisional; Region: PRK03341 698968003062 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 698968003063 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 698968003064 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 698968003065 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 698968003066 ANP binding site [chemical binding]; other site 698968003067 Substrate Binding Site II [chemical binding]; other site 698968003068 Substrate Binding Site I [chemical binding]; other site 698968003069 argininosuccinate lyase; Provisional; Region: PRK00855 698968003070 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 698968003071 active sites [active] 698968003072 tetramer interface [polypeptide binding]; other site 698968003073 Trm112p-like protein; Region: Trm112p; cl01066 698968003074 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 698968003075 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 698968003076 active site 698968003077 HIGH motif; other site 698968003078 dimer interface [polypeptide binding]; other site 698968003079 KMSKS motif; other site 698968003080 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 698968003081 transcription termination factor Rho; Provisional; Region: PRK12678 698968003082 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698968003083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968003084 active site 698968003085 motif I; other site 698968003086 motif II; other site 698968003087 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698968003088 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 698968003089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968003090 RNA binding surface [nucleotide binding]; other site 698968003091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968003092 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 698968003093 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 698968003094 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 698968003095 Walker A/P-loop; other site 698968003096 ATP binding site [chemical binding]; other site 698968003097 Q-loop/lid; other site 698968003098 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 698968003099 ABC transporter signature motif; other site 698968003100 Walker B; other site 698968003101 D-loop; other site 698968003102 H-loop/switch region; other site 698968003103 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 698968003104 Thiamine pyrophosphokinase; Region: TPK; cl08415 698968003105 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 698968003106 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 698968003107 dimer interface [polypeptide binding]; other site 698968003108 ADP-ribose binding site [chemical binding]; other site 698968003109 active site 698968003110 nudix motif; other site 698968003111 metal binding site [ion binding]; metal-binding site 698968003112 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 698968003113 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 698968003114 active site 698968003115 Int/Topo IB signature motif; other site 698968003116 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698968003117 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968003118 P-loop; other site 698968003119 Magnesium ion binding site [ion binding]; other site 698968003120 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968003121 Magnesium ion binding site [ion binding]; other site 698968003122 ScpA/B protein; Region: ScpA_ScpB; cl00598 698968003123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003124 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 698968003125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968003126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 698968003127 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05630 698968003128 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 698968003129 inhibitor-cofactor binding pocket; inhibition site 698968003130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968003131 catalytic residue [active] 698968003132 AAA domain; Region: AAA_26; pfam13500 698968003133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003135 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 698968003136 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 698968003137 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 698968003138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968003139 RNA binding surface [nucleotide binding]; other site 698968003140 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 698968003141 active site 698968003142 cytidylate kinase; Provisional; Region: cmk; PRK00023 698968003143 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 698968003144 CMP-binding site; other site 698968003145 The sites determining sugar specificity; other site 698968003146 GTP-binding protein Der; Reviewed; Region: PRK03003 698968003147 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 698968003148 G1 box; other site 698968003149 GTP/Mg2+ binding site [chemical binding]; other site 698968003150 Switch I region; other site 698968003151 G2 box; other site 698968003152 Switch II region; other site 698968003153 G3 box; other site 698968003154 G4 box; other site 698968003155 G5 box; other site 698968003156 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 698968003157 G1 box; other site 698968003158 GTP/Mg2+ binding site [chemical binding]; other site 698968003159 Switch I region; other site 698968003160 G2 box; other site 698968003161 G3 box; other site 698968003162 Switch II region; other site 698968003163 G4 box; other site 698968003164 G5 box; other site 698968003165 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698968003166 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 698968003167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003168 S-adenosylmethionine binding site [chemical binding]; other site 698968003169 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 698968003170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968003171 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 698968003172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003173 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 698968003174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003175 nucleotide binding region [chemical binding]; other site 698968003176 ATP-binding site [chemical binding]; other site 698968003177 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 698968003178 phosphopeptide binding site; other site 698968003179 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 698968003180 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968003181 DNA binding residues [nucleotide binding] 698968003182 Bifunctional nuclease; Region: DNase-RNase; cl00553 698968003183 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 698968003184 DNA binding residues [nucleotide binding] 698968003185 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968003186 putative dimer interface [polypeptide binding]; other site 698968003187 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698968003188 metal ion-dependent adhesion site (MIDAS); other site 698968003189 Domain of unknown function DUF21; Region: DUF21; pfam01595 698968003190 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698968003191 Domain of unknown function DUF21; Region: DUF21; pfam01595 698968003192 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698968003193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698968003194 Transporter associated domain; Region: CorC_HlyC; cl08393 698968003195 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 698968003196 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 698968003197 ATP binding site [chemical binding]; other site 698968003198 Mg++ binding site [ion binding]; other site 698968003199 motif III; other site 698968003200 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003201 nucleotide binding region [chemical binding]; other site 698968003202 ATP-binding site [chemical binding]; other site 698968003203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003204 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 698968003205 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 698968003206 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 698968003207 CoenzymeA binding site [chemical binding]; other site 698968003208 subunit interaction site [polypeptide binding]; other site 698968003209 PHB binding site; other site 698968003210 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 698968003211 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 698968003212 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698968003213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003214 S-adenosylmethionine binding site [chemical binding]; other site 698968003215 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 698968003216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968003218 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 698968003219 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 698968003220 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698968003221 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 698968003222 potential frameshift: common BLAST hit: gi|227833113|ref|YP_002834820.1| oxidoreductase 698968003223 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698968003224 potential frameshift: common BLAST hit: gi|337290692|ref|YP_004629713.1| putative RNA helicase 698968003225 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 698968003226 FAD binding domain; Region: FAD_binding_4; pfam01565 698968003227 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 698968003228 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 698968003229 Membrane transport protein; Region: Mem_trans; cl09117 698968003230 YceI-like domain; Region: YceI; cl01001 698968003231 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 698968003232 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 698968003233 Ligand binding site; other site 698968003234 Putative Catalytic site; other site 698968003235 DXD motif; other site 698968003236 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 698968003237 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 698968003238 putative active site [active] 698968003239 catalytic triad [active] 698968003240 putative dimer interface [polypeptide binding]; other site 698968003241 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 698968003242 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 698968003243 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698968003244 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 698968003245 precorrin-3B synthase; Region: CobG; TIGR02435 698968003246 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698968003247 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 698968003248 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 698968003249 Precorrin-8X methylmutase; Region: CbiC; pfam02570 698968003250 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968003251 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968003252 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968003253 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968003254 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 698968003255 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 698968003256 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968003257 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968003258 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968003259 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968003260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968003261 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698968003262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003263 NAD(P) binding site [chemical binding]; other site 698968003264 active site 698968003265 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698968003266 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698968003267 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698968003268 active site 698968003269 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 698968003270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003271 ATP binding site [chemical binding]; other site 698968003272 putative Mg++ binding site [ion binding]; other site 698968003273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003274 nucleotide binding region [chemical binding]; other site 698968003275 ATP-binding site [chemical binding]; other site 698968003276 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 698968003277 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698968003278 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 698968003279 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 698968003280 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 698968003281 Predicted transcriptional regulator [Transcription]; Region: COG2378 698968003282 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698968003283 WYL domain; Region: WYL; cl14852 698968003284 WYL domain; Region: WYL; cl14852 698968003285 Pup-ligase protein; Region: Pup_ligase; cl15463 698968003286 Pup-like protein; Region: Pup; cl05289 698968003287 Pup-ligase protein; Region: Pup_ligase; cl15463 698968003288 proteasome ATPase; Region: pup_AAA; TIGR03689 698968003289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968003290 Walker A motif; other site 698968003291 ATP binding site [chemical binding]; other site 698968003292 Walker B motif; other site 698968003293 arginine finger; other site 698968003294 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 698968003295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968003296 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 698968003297 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 698968003298 active site 698968003299 metal binding site [ion binding]; metal-binding site 698968003300 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968003301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698968003302 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 698968003303 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 698968003304 Potassium binding sites [ion binding]; other site 698968003305 Cesium cation binding sites [ion binding]; other site 698968003306 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 698968003307 Aspartase; Region: Aspartase; cd01357 698968003308 active sites [active] 698968003309 tetramer interface [polypeptide binding]; other site 698968003310 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698968003311 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 698968003312 ATP phosphoribosyltransferase; Region: HisG; cl15266 698968003313 HisG, C-terminal domain; Region: HisG_C; cl06867 698968003314 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 698968003315 homodimer interface [polypeptide binding]; other site 698968003316 putative metal binding site [ion binding]; other site 698968003317 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698968003318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968003319 motif II; other site 698968003320 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 698968003321 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 698968003322 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 698968003323 substrate binding pocket [chemical binding]; other site 698968003324 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 698968003325 B12 binding site [chemical binding]; other site 698968003326 cobalt ligand [ion binding]; other site 698968003327 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 698968003328 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 698968003329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968003330 active site 698968003331 HIGH motif; other site 698968003332 nucleotide binding site [chemical binding]; other site 698968003333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968003334 active site 698968003335 KMSKS motif; other site 698968003336 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698968003337 tRNA binding surface [nucleotide binding]; other site 698968003338 anticodon binding site; other site 698968003339 Bacitracin resistance protein BacA; Region: BacA; cl00858 698968003340 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 698968003341 quinone interaction residues [chemical binding]; other site 698968003342 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 698968003343 active site 698968003344 catalytic residues [active] 698968003345 FMN binding site [chemical binding]; other site 698968003346 substrate binding site [chemical binding]; other site 698968003347 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 698968003348 substrate binding site [chemical binding]; other site 698968003349 Helix-turn-helix domains; Region: HTH; cl00088 698968003350 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 698968003351 HTH-like domain; Region: HTH_21; pfam13276 698968003352 Integrase core domain; Region: rve; cl01316 698968003353 Integrase core domain; Region: rve_3; cl15866 698968003354 potential frameshift: common BLAST hit: gi|256379310|ref|YP_003102970.1| oxidoreductase 698968003355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003356 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698968003357 active site residue [active] 698968003358 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698968003359 active site residue [active] 698968003360 membrane ATPase/protein kinase; Provisional; Region: PRK09435 698968003361 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 698968003362 Walker A; other site 698968003363 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 698968003364 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 698968003365 active site 698968003366 substrate binding site [chemical binding]; other site 698968003367 coenzyme B12 binding site [chemical binding]; other site 698968003368 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 698968003369 B12 binding site [chemical binding]; other site 698968003370 cobalt ligand [ion binding]; other site 698968003371 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 698968003372 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 698968003373 heterodimer interface [polypeptide binding]; other site 698968003374 substrate interaction site [chemical binding]; other site 698968003375 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 698968003376 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698968003377 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 698968003378 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968003379 MULE transposase domain; Region: MULE; pfam10551 698968003380 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 698968003381 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 698968003382 ferrochelatase; Reviewed; Region: hemH; PRK00035 698968003383 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 698968003384 C-terminal domain interface [polypeptide binding]; other site 698968003385 active site 698968003386 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 698968003387 active site 698968003388 N-terminal domain interface [polypeptide binding]; other site 698968003389 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 698968003390 NlpC/P60 family; Region: NLPC_P60; cl11438 698968003391 aconitate hydratase; Validated; Region: PRK09277 698968003392 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698968003393 substrate binding site [chemical binding]; other site 698968003394 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 698968003395 ligand binding site [chemical binding]; other site 698968003396 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 698968003397 substrate binding site [chemical binding]; other site 698968003398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968003399 Helix-turn-helix domains; Region: HTH; cl00088 698968003400 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 698968003401 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 698968003402 catalytic triad [active] 698968003403 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 698968003404 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 698968003405 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 698968003406 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698968003407 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003408 Walker A/P-loop; other site 698968003409 ATP binding site [chemical binding]; other site 698968003410 Q-loop/lid; other site 698968003411 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698968003412 ABC transporter signature motif; other site 698968003413 Walker B; other site 698968003414 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698968003415 Domain of unknown function DUF59; Region: DUF59; cl00941 698968003416 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 698968003417 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 698968003418 trimerization site [polypeptide binding]; other site 698968003419 active site 698968003420 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 698968003421 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 698968003422 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968003423 catalytic residue [active] 698968003424 FeS assembly ATPase SufC; Region: sufC; TIGR01978 698968003425 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 698968003426 Walker A/P-loop; other site 698968003427 ATP binding site [chemical binding]; other site 698968003428 Q-loop/lid; other site 698968003429 ABC transporter signature motif; other site 698968003430 Walker B; other site 698968003431 D-loop; other site 698968003432 H-loop/switch region; other site 698968003433 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 698968003434 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 698968003435 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 698968003436 FeS assembly protein SufB; Region: sufB; TIGR01980 698968003437 Helix-turn-helix domains; Region: HTH; cl00088 698968003438 Predicted transcriptional regulator [Transcription]; Region: COG2345 698968003439 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698968003440 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968003441 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 698968003442 Walker A/P-loop; other site 698968003443 ATP binding site [chemical binding]; other site 698968003444 Q-loop/lid; other site 698968003445 ABC transporter signature motif; other site 698968003446 Walker B; other site 698968003447 D-loop; other site 698968003448 H-loop/switch region; other site 698968003449 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698968003450 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 698968003451 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 698968003452 UbiA prenyltransferase family; Region: UbiA; cl00337 698968003453 transketolase; Reviewed; Region: PRK05899 698968003454 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 698968003455 TPP-binding site [chemical binding]; other site 698968003456 dimer interface [polypeptide binding]; other site 698968003457 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698968003458 PYR/PP interface [polypeptide binding]; other site 698968003459 dimer interface [polypeptide binding]; other site 698968003460 TPP binding site [chemical binding]; other site 698968003461 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698968003462 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 698968003463 putative active site [active] 698968003464 transaldolase; Provisional; Region: PRK03903 698968003465 catalytic residue [active] 698968003466 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 698968003467 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 698968003468 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 698968003469 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 698968003470 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 698968003471 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 698968003472 putative active site [active] 698968003473 Preprotein translocase SecG subunit; Region: SecG; cl09123 698968003474 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 698968003475 substrate binding site [chemical binding]; other site 698968003476 dimer interface [polypeptide binding]; other site 698968003477 catalytic triad [active] 698968003478 Phosphoglycerate kinase; Region: PGK; pfam00162 698968003479 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 698968003480 substrate binding site [chemical binding]; other site 698968003481 hinge regions; other site 698968003482 ADP binding site [chemical binding]; other site 698968003483 catalytic site [active] 698968003484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003485 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 698968003486 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 698968003487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 698968003488 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 698968003489 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 698968003490 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 698968003491 phosphate binding site [ion binding]; other site 698968003492 putative substrate binding pocket [chemical binding]; other site 698968003493 dimer interface [polypeptide binding]; other site 698968003494 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 698968003495 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 698968003496 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 698968003497 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 698968003498 GIY-YIG motif/motif A; other site 698968003499 active site 698968003500 catalytic site [active] 698968003501 putative DNA binding site [nucleotide binding]; other site 698968003502 metal binding site [ion binding]; metal-binding site 698968003503 UvrB/uvrC motif; Region: UVR; pfam02151 698968003504 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 698968003505 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 698968003506 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 698968003507 homopentamer interface [polypeptide binding]; other site 698968003508 active site 698968003509 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 698968003510 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 698968003511 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 698968003512 dimerization interface [polypeptide binding]; other site 698968003513 active site 698968003514 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 698968003515 Lumazine binding domain; Region: Lum_binding; pfam00677 698968003516 Lumazine binding domain; Region: Lum_binding; pfam00677 698968003517 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 698968003518 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 698968003519 catalytic motif [active] 698968003520 Zn binding site [ion binding]; other site 698968003521 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 698968003522 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 698968003523 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 698968003524 substrate binding site [chemical binding]; other site 698968003525 hexamer interface [polypeptide binding]; other site 698968003526 metal binding site [ion binding]; metal-binding site 698968003527 16S rRNA methyltransferase B; Provisional; Region: PRK14902 698968003528 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698968003529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968003530 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 698968003531 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 698968003532 putative active site [active] 698968003533 substrate binding site [chemical binding]; other site 698968003534 putative cosubstrate binding site; other site 698968003535 catalytic site [active] 698968003536 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 698968003537 substrate binding site [chemical binding]; other site 698968003538 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698968003539 active site 698968003540 catalytic residues [active] 698968003541 metal binding site [ion binding]; metal-binding site 698968003542 primosome assembly protein PriA; Provisional; Region: PRK14873 698968003543 S-adenosylmethionine synthetase; Validated; Region: PRK05250 698968003544 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698968003545 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698968003546 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698968003547 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 698968003548 Flavoprotein; Region: Flavoprotein; cl08021 698968003549 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 698968003550 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 698968003551 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 698968003552 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 698968003553 catalytic site [active] 698968003554 G-X2-G-X-G-K; other site 698968003555 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 698968003556 active site 698968003557 dimer interface [polypeptide binding]; other site 698968003558 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 698968003559 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968003560 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968003561 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 698968003562 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 698968003563 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968003564 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 698968003565 IMP binding site; other site 698968003566 dimer interface [polypeptide binding]; other site 698968003567 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 698968003568 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 698968003569 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 698968003570 catalytic site [active] 698968003571 subunit interface [polypeptide binding]; other site 698968003572 dihydroorotase; Validated; Region: pyrC; PRK09357 698968003573 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 698968003574 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 698968003575 active site 698968003576 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 698968003577 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 698968003578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968003580 active site 698968003581 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 698968003582 hydrophobic ligand binding site; other site 698968003583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003584 TIGR01777 family protein; Region: yfcH 698968003585 NAD(P) binding site [chemical binding]; other site 698968003586 active site 698968003587 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 698968003588 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 698968003589 elongation factor P; Validated; Region: PRK00529 698968003590 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 698968003591 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 698968003592 RNA binding site [nucleotide binding]; other site 698968003593 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 698968003594 RNA binding site [nucleotide binding]; other site 698968003595 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 698968003596 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 698968003597 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 698968003598 active site 698968003599 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 698968003600 trimer interface [polypeptide binding]; other site 698968003601 active site 698968003602 dimer interface [polypeptide binding]; other site 698968003603 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 698968003604 active site 698968003605 dimer interface [polypeptide binding]; other site 698968003606 metal binding site [ion binding]; metal-binding site 698968003607 shikimate kinase; Reviewed; Region: aroK; PRK00131 698968003608 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 698968003609 ADP binding site [chemical binding]; other site 698968003610 magnesium binding site [ion binding]; other site 698968003611 putative shikimate binding site; other site 698968003612 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 698968003613 Tetramer interface [polypeptide binding]; other site 698968003614 active site 698968003615 FMN-binding site [chemical binding]; other site 698968003616 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 698968003617 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 698968003618 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 698968003619 shikimate binding site; other site 698968003620 NAD(P) binding site [chemical binding]; other site 698968003621 YceG-like family; Region: YceG; pfam02618 698968003622 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 698968003623 dimerization interface [polypeptide binding]; other site 698968003624 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 698968003625 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 698968003626 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 698968003627 motif 1; other site 698968003628 active site 698968003629 motif 2; other site 698968003630 motif 3; other site 698968003631 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 698968003632 DHHA1 domain; Region: DHHA1; pfam02272 698968003633 recombination factor protein RarA; Reviewed; Region: PRK13342 698968003634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968003635 Walker A motif; other site 698968003636 ATP binding site [chemical binding]; other site 698968003637 Walker B motif; other site 698968003638 arginine finger; other site 698968003639 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 698968003640 Phosphotransferase enzyme family; Region: APH; pfam01636 698968003641 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 698968003642 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 698968003643 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 698968003644 dimer interface [polypeptide binding]; other site 698968003645 anticodon binding site; other site 698968003646 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 698968003647 homodimer interface [polypeptide binding]; other site 698968003648 motif 1; other site 698968003649 active site 698968003650 motif 2; other site 698968003651 GAD domain; Region: GAD; pfam02938 698968003652 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 698968003653 active site 698968003654 motif 3; other site 698968003655 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 698968003656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003657 ATP binding site [chemical binding]; other site 698968003658 putative Mg++ binding site [ion binding]; other site 698968003659 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003660 nucleotide binding region [chemical binding]; other site 698968003661 ATP-binding site [chemical binding]; other site 698968003662 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698968003663 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968003664 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968003665 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968003666 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 698968003667 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698968003668 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003669 ATP binding site [chemical binding]; other site 698968003670 Q-loop/lid; other site 698968003671 ABC transporter signature motif; other site 698968003672 Walker B; other site 698968003673 D-loop; other site 698968003674 H-loop/switch region; other site 698968003675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968003676 Helix-turn-helix domains; Region: HTH; cl00088 698968003677 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 698968003678 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 698968003679 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 698968003680 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 698968003681 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 698968003682 dimer interface [polypeptide binding]; other site 698968003683 motif 1; other site 698968003684 active site 698968003685 motif 2; other site 698968003686 motif 3; other site 698968003687 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 698968003688 anticodon binding site; other site 698968003689 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698968003690 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 698968003691 dimer interface [polypeptide binding]; other site 698968003692 catalytic triad [active] 698968003693 peroxidatic and resolving cysteines [active] 698968003694 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 698968003695 active site 698968003696 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 698968003697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968003698 Zn2+ binding site [ion binding]; other site 698968003699 Mg2+ binding site [ion binding]; other site 698968003700 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698968003701 synthetase active site [active] 698968003702 NTP binding site [chemical binding]; other site 698968003703 metal binding site [ion binding]; metal-binding site 698968003704 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 698968003705 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 698968003706 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968003707 active site 698968003708 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 698968003709 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 698968003710 Protein export membrane protein; Region: SecD_SecF; cl14618 698968003711 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 698968003712 Protein export membrane protein; Region: SecD_SecF; cl14618 698968003713 Preprotein translocase subunit; Region: YajC; cl00806 698968003714 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 698968003715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968003716 Walker A motif; other site 698968003717 ATP binding site [chemical binding]; other site 698968003718 Walker B motif; other site 698968003719 arginine finger; other site 698968003720 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 698968003721 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 698968003722 RuvA N terminal domain; Region: RuvA_N; pfam01330 698968003723 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 698968003724 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 698968003725 active site 698968003726 putative DNA-binding cleft [nucleotide binding]; other site 698968003727 dimer interface [polypeptide binding]; other site 698968003728 Transcriptional regulator; Region: Transcrip_reg; cl00361 698968003729 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 698968003730 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 698968003731 active site 698968003732 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 698968003733 catalytic triad [active] 698968003734 dimer interface [polypeptide binding]; other site 698968003735 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 698968003736 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 698968003737 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 698968003738 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968003739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968003740 catalytic residue [active] 698968003741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968003742 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968003743 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 698968003744 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 698968003745 putative acyl-acceptor binding pocket; other site 698968003746 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 698968003747 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 698968003748 nucleotide binding site/active site [active] 698968003749 HIT family signature motif; other site 698968003750 catalytic residue [active] 698968003751 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 698968003752 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 698968003753 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 698968003754 active site 698968003755 dimer interface [polypeptide binding]; other site 698968003756 motif 1; other site 698968003757 motif 2; other site 698968003758 motif 3; other site 698968003759 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 698968003760 anticodon binding site; other site 698968003761 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 698968003762 Protein of unknown function (DUF461); Region: DUF461; cl01071 698968003763 Bacterial Ig-like domain; Region: Big_5; cl01012 698968003764 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 698968003765 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 698968003766 SelR domain; Region: SelR; pfam01641 698968003767 Chlorite dismutase; Region: Chlor_dismutase; cl01280 698968003768 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 698968003769 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 698968003770 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 698968003771 catalytic site [active] 698968003772 putative active site [active] 698968003773 putative substrate binding site [chemical binding]; other site 698968003774 HRDC domain; Region: HRDC; cl02578 698968003775 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 698968003776 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 698968003777 TPP-binding site; other site 698968003778 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 698968003779 PYR/PP interface [polypeptide binding]; other site 698968003780 dimer interface [polypeptide binding]; other site 698968003781 TPP binding site [chemical binding]; other site 698968003782 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 698968003783 TRAM domain; Region: TRAM; cl01282 698968003784 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 698968003785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968003786 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 698968003787 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698968003788 trimer interface [polypeptide binding]; other site 698968003789 active site 698968003790 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 698968003791 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 698968003792 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 698968003793 active site 698968003794 dimerization interface [polypeptide binding]; other site 698968003795 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 698968003796 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 698968003797 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698968003798 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698968003799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968003800 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698968003801 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968003802 DNA binding residues [nucleotide binding] 698968003803 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968003804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003805 ATP binding site [chemical binding]; other site 698968003806 putative Mg++ binding site [ion binding]; other site 698968003807 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 698968003808 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 698968003809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968003810 S-adenosylmethionine binding site [chemical binding]; other site 698968003811 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 698968003812 putative active site [active] 698968003813 dimerization interface [polypeptide binding]; other site 698968003814 putative tRNAtyr binding site [nucleotide binding]; other site 698968003815 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 698968003816 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 698968003817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968003818 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 698968003819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 698968003820 DNA binding residues [nucleotide binding] 698968003821 Helix-turn-helix domains; Region: HTH; cl00088 698968003822 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 698968003823 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 698968003824 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 698968003825 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 698968003826 NAD binding site [chemical binding]; other site 698968003827 homodimer interface [polypeptide binding]; other site 698968003828 active site 698968003829 substrate binding site [chemical binding]; other site 698968003830 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 698968003831 PAC2 family; Region: PAC2; cl00847 698968003832 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003833 ATP binding site [chemical binding]; other site 698968003834 putative Mg++ binding site [ion binding]; other site 698968003835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003836 nucleotide binding region [chemical binding]; other site 698968003837 ATP-binding site [chemical binding]; other site 698968003838 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 698968003839 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 698968003840 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 698968003841 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 698968003842 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 698968003843 dimer interface [polypeptide binding]; other site 698968003844 decamer (pentamer of dimers) interface [polypeptide binding]; other site 698968003845 catalytic triad [active] 698968003846 peroxidatic and resolving cysteines [active] 698968003847 Helix-turn-helix domains; Region: HTH; cl00088 698968003848 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 698968003849 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 698968003850 dimerization interface [polypeptide binding]; other site 698968003851 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 698968003852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968003853 ATP binding site [chemical binding]; other site 698968003854 putative Mg++ binding site [ion binding]; other site 698968003855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968003856 nucleotide binding region [chemical binding]; other site 698968003857 ATP-binding site [chemical binding]; other site 698968003858 Helicase associated domain (HA2); Region: HA2; cl04503 698968003859 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 698968003860 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 698968003861 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 698968003862 ATP cone domain; Region: ATP-cone; pfam03477 698968003863 LexA repressor; Validated; Region: PRK00215 698968003864 Helix-turn-helix domains; Region: HTH; cl00088 698968003865 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 698968003866 Catalytic site [active] 698968003867 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698968003868 Helix-turn-helix domains; Region: HTH; cl00088 698968003869 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698968003870 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 698968003871 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 698968003872 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 698968003873 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 698968003874 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 698968003875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968003876 DNA-binding site [nucleotide binding]; DNA binding site 698968003877 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698968003878 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 698968003879 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 698968003880 putative substrate binding site [chemical binding]; other site 698968003881 putative ATP binding site [chemical binding]; other site 698968003882 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698968003883 dimerization domain swap beta strand [polypeptide binding]; other site 698968003884 regulatory protein interface [polypeptide binding]; other site 698968003885 active site 698968003886 regulatory phosphorylation site [posttranslational modification]; other site 698968003887 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 698968003888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698968003889 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698968003890 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 698968003891 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 698968003892 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 698968003893 HflX GTPase family; Region: HflX; cd01878 698968003894 G1 box; other site 698968003895 GTP/Mg2+ binding site [chemical binding]; other site 698968003896 Switch I region; other site 698968003897 G2 box; other site 698968003898 G3 box; other site 698968003899 Switch II region; other site 698968003900 G4 box; other site 698968003901 G5 box; other site 698968003902 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 698968003903 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698968003904 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 698968003905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003906 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 698968003907 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698968003908 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698968003909 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 698968003910 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 698968003911 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 698968003912 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 698968003913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968003914 FeS/SAM binding site; other site 698968003915 RecX family; Region: RecX; cl00936 698968003916 recombinase A; Provisional; Region: recA; PRK09354 698968003917 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 698968003918 hexamer interface [polypeptide binding]; other site 698968003919 Walker A motif; other site 698968003920 ATP binding site [chemical binding]; other site 698968003921 Walker B motif; other site 698968003922 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 698968003923 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 698968003924 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 698968003925 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 698968003926 Walker A/P-loop; other site 698968003927 ATP binding site [chemical binding]; other site 698968003928 Q-loop/lid; other site 698968003929 ABC transporter signature motif; other site 698968003930 Walker B; other site 698968003931 D-loop; other site 698968003932 H-loop/switch region; other site 698968003933 Cobalt transport protein; Region: CbiQ; cl00463 698968003934 PspA/IM30 family; Region: PspA_IM30; pfam04012 698968003935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 698968003936 sequence-specific DNA binding site [nucleotide binding]; other site 698968003937 salt bridge; other site 698968003938 Competence-damaged protein; Region: CinA; cl00666 698968003939 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 698968003940 YCII-related domain; Region: YCII; cl00999 698968003941 Integral membrane protein TerC family; Region: TerC; cl10468 698968003942 DNA translocase FtsK; Provisional; Region: PRK10263 698968003943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968003944 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 698968003945 TIGR03085 family protein; Region: TIGR03085 698968003946 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 698968003947 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698968003948 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 698968003949 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698968003950 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 698968003951 dimer interface [polypeptide binding]; other site 698968003952 active site 698968003953 catalytic residue [active] 698968003954 Thymidylate synthase complementing protein; Region: Thy1; cl03630 698968003955 dihydrodipicolinate reductase; Provisional; Region: PRK00048 698968003956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968003957 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 698968003958 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 698968003959 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 698968003960 oligomer interface [polypeptide binding]; other site 698968003961 RNA binding site [nucleotide binding]; other site 698968003962 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 698968003963 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 698968003964 RNase E interface [polypeptide binding]; other site 698968003965 trimer interface [polypeptide binding]; other site 698968003966 active site 698968003967 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 698968003968 putative nucleic acid binding region [nucleotide binding]; other site 698968003969 G-X-X-G motif; other site 698968003970 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 698968003971 RNA binding site [nucleotide binding]; other site 698968003972 domain interface; other site 698968003973 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 698968003974 16S/18S rRNA binding site [nucleotide binding]; other site 698968003975 S13e-L30e interaction site [polypeptide binding]; other site 698968003976 25S rRNA binding site [nucleotide binding]; other site 698968003977 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 698968003978 active site 698968003979 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 698968003980 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 698968003981 active site 698968003982 Riboflavin kinase; Region: Flavokinase; cl03312 698968003983 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 698968003984 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 698968003985 RNA binding site [nucleotide binding]; other site 698968003986 active site 698968003987 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 698968003988 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 698968003989 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 698968003990 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 698968003991 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 698968003992 active site 698968003993 metal binding site [ion binding]; metal-binding site 698968003994 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 698968003995 MatE; Region: MatE; cl10513 698968003996 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 698968003997 DHH family; Region: DHH; pfam01368 698968003998 Ribosome-binding factor A; Region: RBFA; cl00542 698968003999 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698968004000 translation initiation factor IF-2; Region: IF-2; TIGR00487 698968004001 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698968004002 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 698968004003 G1 box; other site 698968004004 putative GEF interaction site [polypeptide binding]; other site 698968004005 GTP/Mg2+ binding site [chemical binding]; other site 698968004006 Switch I region; other site 698968004007 G2 box; other site 698968004008 G3 box; other site 698968004009 Switch II region; other site 698968004010 G4 box; other site 698968004011 G5 box; other site 698968004012 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 698968004013 Translation-initiation factor 2; Region: IF-2; pfam11987 698968004014 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 698968004015 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 698968004016 putative RNA binding cleft [nucleotide binding]; other site 698968004017 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 698968004018 NusA N-terminal domain; Region: NusA_N; pfam08529 698968004019 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 698968004020 RNA binding site [nucleotide binding]; other site 698968004021 homodimer interface [polypeptide binding]; other site 698968004022 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 698968004023 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 698968004024 G-X-X-G motif; other site 698968004025 ribosome maturation protein RimP; Reviewed; Region: PRK00092 698968004026 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 698968004027 prolyl-tRNA synthetase; Provisional; Region: PRK09194 698968004028 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 698968004029 dimer interface [polypeptide binding]; other site 698968004030 motif 1; other site 698968004031 active site 698968004032 motif 2; other site 698968004033 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 698968004034 putative deacylase active site [active] 698968004035 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 698968004036 active site 698968004037 motif 3; other site 698968004038 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 698968004039 anticodon binding site; other site 698968004040 Protein of unknown function (DUF328); Region: DUF328; cl01143 698968004041 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 698968004042 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 698968004043 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 698968004044 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 698968004045 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 698968004046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004047 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 698968004048 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 698968004049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004050 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 698968004051 catalytic triad [active] 698968004052 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 698968004053 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 698968004054 Walker A motif; other site 698968004055 homodimer interface [polypeptide binding]; other site 698968004056 ATP binding site [chemical binding]; other site 698968004057 hydroxycobalamin binding site [chemical binding]; other site 698968004058 Walker B motif; other site 698968004059 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 698968004060 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 698968004061 metal ion-dependent adhesion site (MIDAS); other site 698968004062 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 698968004063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968004064 Walker A motif; other site 698968004065 ATP binding site [chemical binding]; other site 698968004066 Walker B motif; other site 698968004067 arginine finger; other site 698968004068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968004069 Predicted dehydrogenase [General function prediction only]; Region: COG0579 698968004070 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698968004071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968004072 mycothione reductase; Region: mycothione_red; TIGR03452 698968004073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968004074 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968004075 cobyric acid synthase; Provisional; Region: PRK00784 698968004076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004078 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 698968004079 catalytic triad [active] 698968004080 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 698968004081 active site 698968004082 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 698968004083 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 698968004084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968004085 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 698968004086 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698968004087 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 698968004088 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 698968004089 active site 698968004090 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 698968004091 protein binding site [polypeptide binding]; other site 698968004092 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 698968004093 putative substrate binding region [chemical binding]; other site 698968004094 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 698968004095 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 698968004096 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 698968004097 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 698968004098 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 698968004099 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 698968004100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004101 FeS/SAM binding site; other site 698968004102 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 698968004103 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 698968004104 ribosome recycling factor; Reviewed; Region: frr; PRK00083 698968004105 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 698968004106 hinge region; other site 698968004107 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 698968004108 putative nucleotide binding site [chemical binding]; other site 698968004109 uridine monophosphate binding site [chemical binding]; other site 698968004110 homohexameric interface [polypeptide binding]; other site 698968004111 elongation factor Ts; Provisional; Region: tsf; PRK09377 698968004112 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 698968004113 Elongation factor TS; Region: EF_TS; pfam00889 698968004114 Elongation factor TS; Region: EF_TS; pfam00889 698968004115 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 698968004116 rRNA interaction site [nucleotide binding]; other site 698968004117 S8 interaction site; other site 698968004118 putative laminin-1 binding site; other site 698968004119 Peptidase family M23; Region: Peptidase_M23; pfam01551 698968004120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 698968004121 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 698968004122 active site 698968004123 DNA binding site [nucleotide binding] 698968004124 Int/Topo IB signature motif; other site 698968004125 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 698968004126 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 698968004127 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 698968004128 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 698968004129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968004130 Walker A motif; other site 698968004131 ATP binding site [chemical binding]; other site 698968004132 Walker B motif; other site 698968004133 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 698968004134 Restriction endonuclease; Region: Mrr_cat; cl00516 698968004135 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 698968004136 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 698968004137 RNA/DNA hybrid binding site [nucleotide binding]; other site 698968004138 active site 698968004139 signal peptidase I; Provisional; Region: PRK10861 698968004140 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 698968004141 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698968004142 Catalytic site [active] 698968004143 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 698968004144 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 698968004145 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 698968004146 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 698968004147 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 698968004148 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 698968004149 RNA binding site [nucleotide binding]; other site 698968004150 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 698968004151 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 698968004152 RimM N-terminal domain; Region: RimM; pfam01782 698968004153 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 698968004154 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 698968004155 signal recognition particle protein; Provisional; Region: PRK10867 698968004156 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 698968004157 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 698968004158 P loop; other site 698968004159 GTP binding site [chemical binding]; other site 698968004160 Signal peptide binding domain; Region: SRP_SPB; pfam02978 698968004161 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 698968004162 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968004163 metal binding triad; other site 698968004164 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698968004165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 698968004166 Nitrogen regulatory protein P-II; Region: P-II; cl00412 698968004167 Nitrogen regulatory protein P-II; Region: P-II; smart00938 698968004168 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 698968004169 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 698968004170 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 698968004171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004172 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698968004173 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 698968004174 Walker A/P-loop; other site 698968004175 ATP binding site [chemical binding]; other site 698968004176 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 698968004177 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 698968004178 ABC transporter signature motif; other site 698968004179 Walker B; other site 698968004180 D-loop; other site 698968004181 H-loop/switch region; other site 698968004182 Acylphosphatase; Region: Acylphosphatase; cl00551 698968004183 potential frameshift: common BLAST hit: gi|38234117|ref|NP_939884.1| amino acid carrier protein 698968004184 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698968004185 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698968004186 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 698968004187 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 698968004188 DNA binding site [nucleotide binding] 698968004189 catalytic residue [active] 698968004190 H2TH interface [polypeptide binding]; other site 698968004191 putative catalytic residues [active] 698968004192 turnover-facilitating residue; other site 698968004193 intercalation triad [nucleotide binding]; other site 698968004194 8OG recognition residue [nucleotide binding]; other site 698968004195 putative reading head residues; other site 698968004196 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698968004197 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698968004198 ribonuclease III; Reviewed; Region: rnc; PRK00102 698968004199 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 698968004200 dimerization interface [polypeptide binding]; other site 698968004201 active site 698968004202 metal binding site [ion binding]; metal-binding site 698968004203 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 698968004204 dsRNA binding site [nucleotide binding]; other site 698968004205 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 698968004206 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 698968004207 glutamate dehydrogenase; Provisional; Region: PRK09414 698968004208 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 698968004209 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 698968004210 NAD(P) binding site [chemical binding]; other site 698968004211 Glycerate kinase family; Region: Gly_kinase; cl00841 698968004212 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 698968004213 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698968004214 nucleotide binding site/active site [active] 698968004215 HIT family signature motif; other site 698968004216 catalytic residue [active] 698968004217 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 698968004218 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 698968004219 metal binding site [ion binding]; metal-binding site 698968004220 putative dimer interface [polypeptide binding]; other site 698968004221 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 698968004222 homodimer interface [polypeptide binding]; other site 698968004223 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 698968004224 active site pocket [active] 698968004225 pyruvate kinase; Provisional; Region: PRK06247 698968004226 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 698968004227 domain interfaces; other site 698968004228 active site 698968004229 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 698968004230 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698968004231 active site 698968004232 ribulose/triose binding site [chemical binding]; other site 698968004233 phosphate binding site [ion binding]; other site 698968004234 substrate (anthranilate) binding pocket [chemical binding]; other site 698968004235 product (indole) binding pocket [chemical binding]; other site 698968004236 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 698968004237 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 698968004238 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 698968004239 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 698968004240 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 698968004241 substrate binding site [chemical binding]; other site 698968004242 glutamase interaction surface [polypeptide binding]; other site 698968004243 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 698968004244 active site 698968004245 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 698968004246 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 698968004247 catalytic residues [active] 698968004248 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 698968004249 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 698968004250 putative active site [active] 698968004251 oxyanion strand; other site 698968004252 catalytic triad [active] 698968004253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 698968004254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004256 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 698968004257 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 698968004258 putative active site pocket [active] 698968004259 4-fold oligomerization interface [polypeptide binding]; other site 698968004260 metal binding residues [ion binding]; metal-binding site 698968004261 3-fold/trimer interface [polypeptide binding]; other site 698968004262 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 698968004263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968004264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004265 homodimer interface [polypeptide binding]; other site 698968004266 catalytic residue [active] 698968004267 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 698968004268 histidinol dehydrogenase; Region: hisD; TIGR00069 698968004269 NAD binding site [chemical binding]; other site 698968004270 dimerization interface [polypeptide binding]; other site 698968004271 product binding site; other site 698968004272 substrate binding site [chemical binding]; other site 698968004273 zinc binding site [ion binding]; other site 698968004274 catalytic residues [active] 698968004275 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 698968004276 tetracycline repressor protein TetR; Provisional; Region: PRK13756 698968004277 Helix-turn-helix domains; Region: HTH; cl00088 698968004278 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 698968004279 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 698968004280 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 698968004281 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 698968004282 active site 698968004283 catalytic site [active] 698968004284 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 698968004285 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 698968004286 active site 698968004287 catalytic site [active] 698968004288 substrate binding site [chemical binding]; other site 698968004289 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 698968004290 synthetase active site [active] 698968004291 NTP binding site [chemical binding]; other site 698968004292 metal binding site [ion binding]; metal-binding site 698968004293 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968004294 RNA binding surface [nucleotide binding]; other site 698968004295 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 698968004296 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 698968004297 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 698968004298 threonine dehydratase; Validated; Region: PRK08639 698968004299 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 698968004300 tetramer interface [polypeptide binding]; other site 698968004301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004302 catalytic residue [active] 698968004303 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 698968004304 putative Ile/Val binding site [chemical binding]; other site 698968004305 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 698968004306 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 698968004307 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 698968004308 generic binding surface II; other site 698968004309 generic binding surface I; other site 698968004310 Predicted permeases [General function prediction only]; Region: RarD; COG2962 698968004311 EamA-like transporter family; Region: EamA; cl01037 698968004312 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 698968004313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 698968004314 RNA binding surface [nucleotide binding]; other site 698968004315 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 698968004316 active site 698968004317 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 698968004318 lipoprotein signal peptidase; Provisional; Region: PRK14787 698968004319 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 698968004320 active site 698968004321 homotetramer interface [polypeptide binding]; other site 698968004322 homodimer interface [polypeptide binding]; other site 698968004323 DNA polymerase IV; Provisional; Region: PRK03348 698968004324 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 698968004325 active site 698968004326 DNA binding site [nucleotide binding] 698968004327 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 698968004328 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698968004329 HIGH motif; other site 698968004330 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 698968004331 active site 698968004332 KMSKS motif; other site 698968004333 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 698968004334 tRNA binding surface [nucleotide binding]; other site 698968004335 anticodon binding site; other site 698968004336 DivIVA domain; Region: DivI1A_domain; TIGR03544 698968004337 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 698968004338 Protein of unknown function (DUF552); Region: DUF552; cl00775 698968004339 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 698968004340 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 698968004341 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 698968004342 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 698968004343 nucleotide binding site [chemical binding]; other site 698968004344 SulA interaction site; other site 698968004345 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 698968004346 Cell division protein FtsQ; Region: FtsQ; pfam03799 698968004347 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 698968004348 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698968004349 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004350 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004351 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 698968004352 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 698968004353 active site 698968004354 homodimer interface [polypeptide binding]; other site 698968004355 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 698968004356 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 698968004357 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004358 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004359 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 698968004360 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 698968004361 Mg++ binding site [ion binding]; other site 698968004362 putative catalytic motif [active] 698968004363 putative substrate binding site [chemical binding]; other site 698968004364 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698968004365 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 698968004366 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004367 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004368 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 698968004369 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 698968004370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 698968004371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004372 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 698968004373 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 698968004374 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968004375 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 698968004376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968004377 cell division protein MraZ; Reviewed; Region: PRK00326 698968004378 MraZ protein; Region: MraZ; pfam02381 698968004379 MraZ protein; Region: MraZ; pfam02381 698968004380 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 698968004381 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968004382 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 698968004383 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 698968004384 FAD binding site [chemical binding]; other site 698968004385 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 698968004386 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 698968004387 substrate binding pocket [chemical binding]; other site 698968004388 chain length determination region; other site 698968004389 substrate-Mg2+ binding site; other site 698968004390 catalytic residues [active] 698968004391 aspartate-rich region 1; other site 698968004392 active site lid residues [active] 698968004393 aspartate-rich region 2; other site 698968004394 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 698968004395 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968004396 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698968004397 active site 698968004398 ATP binding site [chemical binding]; other site 698968004399 substrate binding site [chemical binding]; other site 698968004400 activation loop (A-loop); other site 698968004401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 698968004402 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004403 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004404 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 698968004405 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 698968004406 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 698968004407 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698968004408 putative acyl-acceptor binding pocket; other site 698968004409 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 698968004410 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 698968004411 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968004412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968004413 NlpC/P60 family; Region: NLPC_P60; cl11438 698968004414 NlpC/P60 family; Region: NLPC_P60; cl11438 698968004415 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 698968004416 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 698968004417 heme bH binding site [chemical binding]; other site 698968004418 intrachain domain interface; other site 698968004419 heme bL binding site [chemical binding]; other site 698968004420 interchain domain interface [polypeptide binding]; other site 698968004421 Qo binding site; other site 698968004422 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 698968004423 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698968004424 iron-sulfur cluster [ion binding]; other site 698968004425 [2Fe-2S] cluster binding site [ion binding]; other site 698968004426 Cytochrome c; Region: Cytochrom_C; cl11414 698968004427 Cytochrome c; Region: Cytochrom_C; cl11414 698968004428 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 698968004429 Subunit I/III interface [polypeptide binding]; other site 698968004430 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 698968004431 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 698968004432 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698968004433 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 698968004434 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 698968004435 active site 698968004436 dimer interface [polypeptide binding]; other site 698968004437 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 698968004438 Ligand Binding Site [chemical binding]; other site 698968004439 Molecular Tunnel; other site 698968004440 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 698968004441 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 698968004442 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 698968004443 homotrimer interface [polypeptide binding]; other site 698968004444 Walker A motif; other site 698968004445 GTP binding site [chemical binding]; other site 698968004446 Walker B motif; other site 698968004447 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 698968004448 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 698968004449 putative dimer interface [polypeptide binding]; other site 698968004450 active site pocket [active] 698968004451 putative cataytic base [active] 698968004452 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 698968004453 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 698968004454 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 698968004455 homodimer interface [polypeptide binding]; other site 698968004456 substrate-cofactor binding pocket; other site 698968004457 catalytic residue [active] 698968004458 multifunctional aminopeptidase A; Provisional; Region: PRK00913 698968004459 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 698968004460 interface (dimer of trimers) [polypeptide binding]; other site 698968004461 Substrate-binding/catalytic site; other site 698968004462 Zn-binding sites [ion binding]; other site 698968004463 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 698968004464 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698968004465 E3 interaction surface; other site 698968004466 lipoyl attachment site [posttranslational modification]; other site 698968004467 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 698968004468 E3 interaction surface; other site 698968004469 lipoyl attachment site [posttranslational modification]; other site 698968004470 e3 binding domain; Region: E3_binding; pfam02817 698968004471 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 698968004472 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 698968004473 lipoyl synthase; Provisional; Region: PRK05481 698968004474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004475 FeS/SAM binding site; other site 698968004476 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 698968004477 RDD family; Region: RDD; cl00746 698968004478 glutamine synthetase, type I; Region: GlnA; TIGR00653 698968004479 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698968004480 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698968004481 Predicted peptidase [General function prediction only]; Region: COG4099 698968004482 CsbD-like; Region: CsbD; cl15799 698968004483 Predicted permease [General function prediction only]; Region: COG2056 698968004484 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 698968004485 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968004486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968004487 DNA-binding site [nucleotide binding]; DNA binding site 698968004488 FCD domain; Region: FCD; cl11656 698968004489 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 698968004490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004491 putative substrate translocation pore; other site 698968004492 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 698968004493 nudix motif; other site 698968004494 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 698968004495 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 698968004496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004497 catalytic residue [active] 698968004498 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 698968004499 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 698968004500 heme binding pocket [chemical binding]; other site 698968004501 heme ligand [chemical binding]; other site 698968004502 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 698968004503 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968004504 metal binding triad; other site 698968004505 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698968004506 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 698968004507 metal binding triad; other site 698968004508 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 698968004509 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 698968004510 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 698968004511 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 698968004512 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 698968004513 putative active site; other site 698968004514 putative metal binding residues [ion binding]; other site 698968004515 signature motif; other site 698968004516 putative triphosphate binding site [ion binding]; other site 698968004517 CHAD domain; Region: CHAD; cl10506 698968004518 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 698968004519 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 698968004520 potential frameshift: common BLAST hit: gi|300858911|ref|YP_003783894.1| ribonuclease R 698968004521 RNB domain; Region: RNB; pfam00773 698968004522 Predicted membrane protein [General function prediction only]; Region: COG4194 698968004523 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 698968004524 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 698968004525 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 698968004526 RNA/DNA hybrid binding site [nucleotide binding]; other site 698968004527 active site 698968004528 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968004529 catalytic core [active] 698968004530 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 698968004531 Putative zinc ribbon domain; Region: DUF164; pfam02591 698968004532 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 698968004533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 698968004534 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 698968004535 hypothetical protein; Provisional; Region: PRK07908 698968004536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968004537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004538 homodimer interface [polypeptide binding]; other site 698968004539 catalytic residue [active] 698968004540 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 698968004541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968004542 motif II; other site 698968004543 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 698968004544 CobD/Cbib protein; Region: CobD_Cbib; cl00561 698968004545 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 698968004546 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 698968004547 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 698968004548 dimer interface [polypeptide binding]; other site 698968004549 TPP-binding site [chemical binding]; other site 698968004550 Electron transfer DM13; Region: DM13; cl02735 698968004551 OpgC protein; Region: OpgC_C; cl00792 698968004552 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698968004553 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698968004554 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968004555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968004556 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968004557 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 698968004558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968004559 active site 698968004560 motif I; other site 698968004561 motif II; other site 698968004562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968004563 motif II; other site 698968004564 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968004565 UPF0126 domain; Region: UPF0126; pfam03458 698968004566 UPF0126 domain; Region: UPF0126; pfam03458 698968004567 DNA primase; Validated; Region: dnaG; PRK05667 698968004568 CHC2 zinc finger; Region: zf-CHC2; cl15369 698968004569 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 698968004570 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 698968004571 active site 698968004572 metal binding site [ion binding]; metal-binding site 698968004573 interdomain interaction site; other site 698968004574 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 698968004575 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 698968004576 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 698968004577 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 698968004578 glutaminase active site [active] 698968004579 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 698968004580 dimer interface [polypeptide binding]; other site 698968004581 active site 698968004582 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 698968004583 dimer interface [polypeptide binding]; other site 698968004584 active site 698968004585 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 698968004586 active site 698968004587 barstar interaction site; other site 698968004588 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 698968004589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968004590 Zn2+ binding site [ion binding]; other site 698968004591 Mg2+ binding site [ion binding]; other site 698968004592 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 698968004593 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 698968004594 putative active site [active] 698968004595 Repair protein; Region: Repair_PSII; cl01535 698968004596 glycyl-tRNA synthetase; Provisional; Region: PRK04173 698968004597 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 698968004598 motif 1; other site 698968004599 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 698968004600 dimer interface [polypeptide binding]; other site 698968004601 active site 698968004602 motif 2; other site 698968004603 motif 3; other site 698968004604 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 698968004605 anticodon binding site; other site 698968004606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 698968004607 putative DNA binding site [nucleotide binding]; other site 698968004608 dimerization interface [polypeptide binding]; other site 698968004609 putative Zn2+ binding site [ion binding]; other site 698968004610 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 698968004611 metal binding site 2 [ion binding]; metal-binding site 698968004612 putative DNA binding helix; other site 698968004613 metal binding site 1 [ion binding]; metal-binding site 698968004614 dimer interface [polypeptide binding]; other site 698968004615 structural Zn2+ binding site [ion binding]; other site 698968004616 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 698968004617 diiron binding motif [ion binding]; other site 698968004618 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 698968004619 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 698968004620 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 698968004621 catalytic residue [active] 698968004622 putative FPP diphosphate binding site; other site 698968004623 putative FPP binding hydrophobic cleft; other site 698968004624 dimer interface [polypeptide binding]; other site 698968004625 putative IPP diphosphate binding site; other site 698968004626 Recombination protein O N terminal; Region: RecO_N; cl15812 698968004627 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 698968004628 Recombination protein O C terminal; Region: RecO_C; pfam02565 698968004629 GTPase Era; Reviewed; Region: era; PRK00089 698968004630 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 698968004631 G1 box; other site 698968004632 GTP/Mg2+ binding site [chemical binding]; other site 698968004633 Switch I region; other site 698968004634 G2 box; other site 698968004635 Switch II region; other site 698968004636 G3 box; other site 698968004637 G4 box; other site 698968004638 G5 box; other site 698968004639 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 698968004640 pyridoxamine kinase; Validated; Region: PRK05756 698968004641 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 698968004642 dimer interface [polypeptide binding]; other site 698968004643 pyridoxal binding site [chemical binding]; other site 698968004644 ATP binding site [chemical binding]; other site 698968004645 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 698968004646 Domain of unknown function DUF21; Region: DUF21; pfam01595 698968004647 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 698968004648 Transporter associated domain; Region: CorC_HlyC; cl08393 698968004649 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 698968004650 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 698968004651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 698968004653 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 698968004654 chaperone protein DnaJ; Provisional; Region: PRK14278 698968004655 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698968004656 HSP70 interaction site [polypeptide binding]; other site 698968004657 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698968004658 Zn binding sites [ion binding]; other site 698968004659 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698968004660 dimer interface [polypeptide binding]; other site 698968004661 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 698968004662 Helix-turn-helix domains; Region: HTH; cl00088 698968004663 coproporphyrinogen III oxidase; Validated; Region: PRK05628 698968004664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 698968004665 FeS/SAM binding site; other site 698968004666 HemN C-terminal domain; Region: HemN_C; pfam06969 698968004667 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968004668 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968004669 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 698968004670 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968004671 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 698968004672 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 698968004673 AMP-binding enzyme; Region: AMP-binding; cl15778 698968004674 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 698968004675 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 698968004676 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 698968004677 active site 698968004678 Zn binding site [ion binding]; other site 698968004679 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968004680 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 698968004681 substrate binding pocket [chemical binding]; other site 698968004682 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 698968004683 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 698968004684 active site 698968004685 metal binding site [ion binding]; metal-binding site 698968004686 nudix motif; other site 698968004687 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968004688 active site 698968004689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968004690 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968004691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004692 Walker A/P-loop; other site 698968004693 ATP binding site [chemical binding]; other site 698968004694 Q-loop/lid; other site 698968004695 ABC transporter signature motif; other site 698968004696 Walker B; other site 698968004697 D-loop; other site 698968004698 H-loop/switch region; other site 698968004699 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 698968004700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968004701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968004702 homodimer interface [polypeptide binding]; other site 698968004703 catalytic residue [active] 698968004704 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 698968004705 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 698968004706 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 698968004707 BCCT family transporter; Region: BCCT; cl00569 698968004708 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 698968004709 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 698968004710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968004712 dimer interface [polypeptide binding]; other site 698968004713 conserved gate region; other site 698968004714 putative PBP binding loops; other site 698968004715 ABC-ATPase subunit interface; other site 698968004716 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 698968004717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968004718 dimer interface [polypeptide binding]; other site 698968004719 conserved gate region; other site 698968004720 putative PBP binding loops; other site 698968004721 ABC-ATPase subunit interface; other site 698968004722 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698968004723 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968004724 Walker A/P-loop; other site 698968004725 ATP binding site [chemical binding]; other site 698968004726 Q-loop/lid; other site 698968004727 ABC transporter signature motif; other site 698968004728 Walker B; other site 698968004729 D-loop; other site 698968004730 H-loop/switch region; other site 698968004731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968004732 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968004733 Walker A/P-loop; other site 698968004734 ATP binding site [chemical binding]; other site 698968004735 Q-loop/lid; other site 698968004736 ABC transporter signature motif; other site 698968004737 Walker B; other site 698968004738 D-loop; other site 698968004739 H-loop/switch region; other site 698968004740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968004741 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 698968004742 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 698968004743 N- and C-terminal domain interface [polypeptide binding]; other site 698968004744 active site 698968004745 MgATP binding site [chemical binding]; other site 698968004746 catalytic site [active] 698968004747 metal binding site [ion binding]; metal-binding site 698968004748 carbohydrate binding site [chemical binding]; other site 698968004749 potential frameshift: common BLAST hit: gi|38234319|ref|NP_940086.1| oxidase 698968004750 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 698968004751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968004752 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 698968004753 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 698968004754 active site residue [active] 698968004755 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 698968004756 putative homodimer interface [polypeptide binding]; other site 698968004757 putative homotetramer interface [polypeptide binding]; other site 698968004758 putative allosteric switch controlling residues; other site 698968004759 putative metal binding site [ion binding]; other site 698968004760 putative homodimer-homodimer interface [polypeptide binding]; other site 698968004761 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 698968004762 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 698968004763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968004764 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 698968004765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004766 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 698968004767 active site 698968004768 tetramer interface [polypeptide binding]; other site 698968004769 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 698968004770 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 698968004771 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698968004772 catalytic residues [active] 698968004773 catalytic nucleophile [active] 698968004774 Recombinase; Region: Recombinase; pfam07508 698968004775 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 698968004776 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 698968004777 catalytic residues [active] 698968004778 catalytic nucleophile [active] 698968004779 Recombinase; Region: Recombinase; pfam07508 698968004780 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698968004781 amidase catalytic site [active] 698968004782 Zn binding residues [ion binding]; other site 698968004783 substrate binding site [chemical binding]; other site 698968004784 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 698968004785 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 698968004786 Holin family; Region: Phage_holin_4; cl01989 698968004787 Protein of unknown function (DUF1617); Region: DUF1617; pfam07761 698968004788 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 698968004789 gp58-like protein; Region: Gp58; pfam07902 698968004790 Phage-related protein [Function unknown]; Region: COG4722; cl15832 698968004791 Phage tail protein; Region: Sipho_tail; pfam05709 698968004792 Phage-related minor tail protein [Function unknown]; Region: COG5280 698968004793 Phage-related protein [Function unknown]; Region: COG5412 698968004794 tape measure domain; Region: tape_meas_nterm; TIGR02675 698968004795 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 698968004796 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 698968004797 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 698968004798 oligomerization interface [polypeptide binding]; other site 698968004799 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 698968004800 Phage capsid family; Region: Phage_capsid; pfam05065 698968004801 Clp protease; Region: CLP_protease; pfam00574 698968004802 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 698968004803 oligomer interface [polypeptide binding]; other site 698968004804 active site residues [active] 698968004805 Phage-related protein [Function unknown]; Region: COG4695; cl01923 698968004806 Phage portal protein; Region: Phage_portal; pfam04860 698968004807 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 698968004808 Phage Terminase; Region: Terminase_1; pfam03354 698968004809 ParB-like nuclease domain; Region: ParBc; cl02129 698968004810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968004811 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 698968004812 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 698968004813 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 698968004814 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 698968004815 Phage terminase, small subunit; Region: Terminase_4; cl01525 698968004816 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968004817 active site 698968004818 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 698968004819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968004820 ATP binding site [chemical binding]; other site 698968004821 putative Mg++ binding site [ion binding]; other site 698968004822 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968004823 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 698968004824 D5 N terminal like; Region: D5_N; cl07360 698968004825 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 698968004826 BRO family, N-terminal domain; Region: Bro-N; cl10591 698968004827 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 698968004828 Integrase core domain; Region: rve; cl01316 698968004829 DDE domain; Region: DDE_Tnp_IS240; pfam13610 698968004830 Integrase core domain; Region: rve; cl01316 698968004831 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 698968004832 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 698968004833 active site 698968004834 DNA binding site [nucleotide binding] 698968004835 catalytic site [active] 698968004836 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698968004837 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968004838 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698968004839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698968004840 DNA binding residues [nucleotide binding] 698968004841 Predicted ATPase [General function prediction only]; Region: COG5293 698968004842 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 698968004843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698968004844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004845 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 698968004846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968004847 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 698968004848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968004849 Mrr N-terminal domain; Region: Mrr_N; pfam14338 698968004850 Restriction endonuclease; Region: Mrr_cat; cl00516 698968004851 Abi-like protein; Region: Abi_2; cl01988 698968004852 GTP-binding protein LepA; Provisional; Region: PRK05433 698968004853 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 698968004854 G1 box; other site 698968004855 putative GEF interaction site [polypeptide binding]; other site 698968004856 GTP/Mg2+ binding site [chemical binding]; other site 698968004857 Switch I region; other site 698968004858 G2 box; other site 698968004859 G3 box; other site 698968004860 Switch II region; other site 698968004861 G4 box; other site 698968004862 G5 box; other site 698968004863 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 698968004864 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 698968004865 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 698968004866 PemK-like protein; Region: PemK; cl00995 698968004867 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 698968004868 LysE type translocator; Region: LysE; cl00565 698968004869 hypothetical protein; Validated; Region: PRK05629 698968004870 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 698968004871 Competence protein; Region: Competence; cl00471 698968004872 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 698968004873 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 698968004874 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 698968004875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968004876 catalytic core [active] 698968004877 Oligomerisation domain; Region: Oligomerisation; cl00519 698968004878 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 698968004879 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 698968004880 active site 698968004881 (T/H)XGH motif; other site 698968004882 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 698968004883 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 698968004884 putative catalytic cysteine [active] 698968004885 gamma-glutamyl kinase; Provisional; Region: PRK05429 698968004886 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 698968004887 nucleotide binding site [chemical binding]; other site 698968004888 homotetrameric interface [polypeptide binding]; other site 698968004889 putative phosphate binding site [ion binding]; other site 698968004890 putative allosteric binding site; other site 698968004891 PUA domain; Region: PUA; cl00607 698968004892 GTPase CgtA; Reviewed; Region: obgE; PRK12296 698968004893 GTP1/OBG; Region: GTP1_OBG; pfam01018 698968004894 Obg GTPase; Region: Obg; cd01898 698968004895 G1 box; other site 698968004896 GTP/Mg2+ binding site [chemical binding]; other site 698968004897 Switch I region; other site 698968004898 G2 box; other site 698968004899 G3 box; other site 698968004900 Switch II region; other site 698968004901 G4 box; other site 698968004902 G5 box; other site 698968004903 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 698968004904 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 698968004905 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 698968004906 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 698968004907 translation initiation factor IF-2; Validated; Region: infB; PRK05306 698968004908 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 698968004909 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 698968004910 homodimer interface [polypeptide binding]; other site 698968004911 oligonucleotide binding site [chemical binding]; other site 698968004912 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 698968004913 active site 698968004914 multimer interface [polypeptide binding]; other site 698968004915 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 698968004916 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 698968004917 dimer interface [polypeptide binding]; other site 698968004918 active site 698968004919 CoA binding pocket [chemical binding]; other site 698968004920 hypothetical protein; Provisional; Region: PRK07483 698968004921 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 698968004922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 698968004923 catalytic residue [active] 698968004924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 698968004925 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 698968004926 active site 698968004927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968004928 putative substrate translocation pore; other site 698968004929 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 698968004930 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 698968004931 Helix-turn-helix domains; Region: HTH; cl00088 698968004932 Integrase core domain; Region: rve; cl01316 698968004933 potential frameshift: common BLAST hit: gi|68535288|ref|YP_249993.1| transposase IS3510a 698968004934 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968004935 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 698968004936 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 698968004937 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 698968004938 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 698968004939 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968004940 active site 698968004941 HIGH motif; other site 698968004942 nucleotide binding site [chemical binding]; other site 698968004943 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698968004944 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 698968004945 active site 698968004946 KMSKS motif; other site 698968004947 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 698968004948 tRNA binding surface [nucleotide binding]; other site 698968004949 anticodon binding site; other site 698968004950 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 698968004951 malate dehydrogenase; Provisional; Region: PRK05442 698968004952 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 698968004953 NAD(P) binding site [chemical binding]; other site 698968004954 dimer interface [polypeptide binding]; other site 698968004955 malate binding site [chemical binding]; other site 698968004956 Helix-turn-helix domains; Region: HTH; cl00088 698968004957 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 698968004958 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 698968004959 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 698968004960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968004961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968004962 Walker A motif; other site 698968004963 ATP binding site [chemical binding]; other site 698968004964 Walker B motif; other site 698968004965 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698968004966 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698968004967 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698968004968 glutamine binding [chemical binding]; other site 698968004969 catalytic triad [active] 698968004970 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 698968004971 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698968004972 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 698968004973 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 698968004974 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698968004975 oligomer interface [polypeptide binding]; other site 698968004976 active site residues [active] 698968004977 Clp protease; Region: CLP_protease; pfam00574 698968004978 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 698968004979 oligomer interface [polypeptide binding]; other site 698968004980 active site residues [active] 698968004981 trigger factor; Provisional; Region: tig; PRK01490 698968004982 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 698968004983 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 698968004984 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 698968004985 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 698968004986 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 698968004987 catalytic residues [active] 698968004988 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 698968004989 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 698968004990 Zn binding site [ion binding]; other site 698968004991 Mechanosensitive ion channel; Region: MS_channel; pfam00924 698968004992 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 698968004993 apolar tunnel; other site 698968004994 heme binding site [chemical binding]; other site 698968004995 dimerization interface [polypeptide binding]; other site 698968004996 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 698968004997 active site 698968004998 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 698968004999 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005000 Walker A/P-loop; other site 698968005001 ATP binding site [chemical binding]; other site 698968005002 Q-loop/lid; other site 698968005003 ABC transporter signature motif; other site 698968005004 Walker B; other site 698968005005 D-loop; other site 698968005006 H-loop/switch region; other site 698968005007 ABC transporter; Region: ABC_tran_2; pfam12848 698968005008 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 698968005009 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698968005010 dimer interface [polypeptide binding]; other site 698968005011 ssDNA binding site [nucleotide binding]; other site 698968005012 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968005013 Copper resistance protein D; Region: CopD; cl00563 698968005014 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 698968005015 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 698968005016 Carbon starvation protein CstA; Region: CstA; pfam02554 698968005017 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 698968005018 Protein of unknown function (DUF466); Region: DUF466; cl01082 698968005019 putative transposase OrfB; Reviewed; Region: PHA02517 698968005020 HTH-like domain; Region: HTH_21; pfam13276 698968005021 Integrase core domain; Region: rve; cl01316 698968005022 Integrase core domain; Region: rve_3; cl15866 698968005023 Helix-turn-helix domains; Region: HTH; cl00088 698968005024 Helix-turn-helix domains; Region: HTH; cl00088 698968005025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 698968005026 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 698968005027 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 698968005028 NADP binding site [chemical binding]; other site 698968005029 dimer interface [polypeptide binding]; other site 698968005030 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 698968005031 classical (c) SDRs; Region: SDR_c; cd05233 698968005032 NAD(P) binding site [chemical binding]; other site 698968005033 active site 698968005034 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 698968005035 catalytic site [active] 698968005036 putative active site [active] 698968005037 putative substrate binding site [chemical binding]; other site 698968005038 dimer interface [polypeptide binding]; other site 698968005039 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 698968005040 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 698968005041 inhibitor site; inhibition site 698968005042 active site 698968005043 dimer interface [polypeptide binding]; other site 698968005044 catalytic residue [active] 698968005045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 698968005046 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 698968005047 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 698968005048 conserved cis-peptide bond; other site 698968005049 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 698968005050 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 698968005051 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 698968005052 catalytic triad [active] 698968005053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968005054 Helix-turn-helix domains; Region: HTH; cl00088 698968005055 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 698968005056 Acyl transferase domain; Region: Acyl_transf_1; cl08282 698968005057 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 698968005058 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 698968005059 FMN binding site [chemical binding]; other site 698968005060 substrate binding site [chemical binding]; other site 698968005061 putative catalytic residue [active] 698968005062 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 698968005063 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 698968005064 active site 2 [active] 698968005065 active site 1 [active] 698968005066 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 698968005067 Acyl transferase domain; Region: Acyl_transf_1; cl08282 698968005068 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 698968005069 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 698968005070 putative NAD(P) binding site [chemical binding]; other site 698968005071 active site 698968005072 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 698968005073 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 698968005074 active site 698968005075 Glucitol operon activator protein (GutM); Region: GutM; cl01890 698968005076 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 698968005077 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 698968005078 active site 698968005079 dimerization interface [polypeptide binding]; other site 698968005080 ribonuclease PH; Reviewed; Region: rph; PRK00173 698968005081 Ribonuclease PH; Region: RNase_PH_bact; cd11362 698968005082 hexamer interface [polypeptide binding]; other site 698968005083 active site 698968005084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 698968005085 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 698968005086 Rhomboid family; Region: Rhomboid; cl11446 698968005087 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 698968005088 putative active site pocket [active] 698968005089 cleavage site 698968005090 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 698968005091 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 698968005092 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 698968005093 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 698968005094 active site 698968005095 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 698968005096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005098 putative Mg++ binding site [ion binding]; other site 698968005099 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 698968005101 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968005102 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 698968005103 active site 698968005104 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; COG1990 698968005105 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 698968005106 dimer interface [polypeptide binding]; other site 698968005107 putative active site [active] 698968005108 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 698968005109 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 698968005110 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 698968005111 phosphoserine phosphatase SerB; Region: serB; TIGR00338 698968005112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968005113 motif II; other site 698968005114 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 698968005115 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 698968005116 D-pathway; other site 698968005117 Putative ubiquinol binding site [chemical binding]; other site 698968005118 Low-spin heme (heme b) binding site [chemical binding]; other site 698968005119 Putative water exit pathway; other site 698968005120 Binuclear center (heme o3/CuB) [ion binding]; other site 698968005121 K-pathway; other site 698968005122 Putative proton exit pathway; other site 698968005123 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698968005124 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698968005125 dimer interface [polypeptide binding]; other site 698968005126 putative radical transfer pathway; other site 698968005127 diiron center [ion binding]; other site 698968005128 tyrosyl radical; other site 698968005129 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 698968005130 Ferritin-like domain; Region: Ferritin; pfam00210 698968005131 ferroxidase diiron center [ion binding]; other site 698968005132 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 698968005133 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 698968005134 Class I ribonucleotide reductase; Region: RNR_I; cd01679 698968005135 active site 698968005136 dimer interface [polypeptide binding]; other site 698968005137 catalytic residues [active] 698968005138 effector binding site; other site 698968005139 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 698968005140 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698968005141 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 698968005142 catalytic residues [active] 698968005143 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 698968005144 active site lid residues [active] 698968005145 substrate binding pocket [chemical binding]; other site 698968005146 catalytic residues [active] 698968005147 substrate-Mg2+ binding site; other site 698968005148 aspartate-rich region 1; other site 698968005149 aspartate-rich region 2; other site 698968005150 phytoene desaturase; Region: crtI_fam; TIGR02734 698968005151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968005152 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 698968005153 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 698968005154 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 698968005155 homodimer interface [polypeptide binding]; other site 698968005156 NAD binding pocket [chemical binding]; other site 698968005157 ATP binding pocket [chemical binding]; other site 698968005158 Mg binding site [ion binding]; other site 698968005159 active-site loop [active] 698968005160 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 698968005161 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698968005162 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 698968005163 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 698968005164 Predicted transcriptional regulator [Transcription]; Region: COG2345 698968005165 Helix-turn-helix domains; Region: HTH; cl00088 698968005166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 698968005167 DoxX; Region: DoxX; cl00976 698968005168 phosphoglucomutase; Validated; Region: PRK07564 698968005169 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 698968005170 active site 698968005171 substrate binding site [chemical binding]; other site 698968005172 metal binding site [ion binding]; metal-binding site 698968005173 CrcB-like protein; Region: CRCB; cl09114 698968005174 CrcB-like protein; Region: CRCB; cl09114 698968005175 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968005176 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 698968005177 FtsX-like permease family; Region: FtsX; cl15850 698968005178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968005179 FtsX-like permease family; Region: FtsX; cl15850 698968005180 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968005181 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698968005182 Walker A/P-loop; other site 698968005183 ATP binding site [chemical binding]; other site 698968005184 Q-loop/lid; other site 698968005185 ABC transporter signature motif; other site 698968005186 Walker B; other site 698968005187 D-loop; other site 698968005188 H-loop/switch region; other site 698968005189 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 698968005190 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 698968005191 hinge; other site 698968005192 active site 698968005193 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 698968005194 GAF domain; Region: GAF_2; pfam13185 698968005195 GAF domain; Region: GAF; cl15785 698968005196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968005197 DNA binding residues [nucleotide binding] 698968005198 dimerization interface [polypeptide binding]; other site 698968005199 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 698968005200 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 698968005201 dimer interface [polypeptide binding]; other site 698968005202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968005203 catalytic residue [active] 698968005204 serine O-acetyltransferase; Region: cysE; TIGR01172 698968005205 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 698968005206 trimer interface [polypeptide binding]; other site 698968005207 active site 698968005208 substrate binding site [chemical binding]; other site 698968005209 CoA binding site [chemical binding]; other site 698968005210 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968005211 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 698968005212 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 698968005213 putative active site [active] 698968005214 metal binding site [ion binding]; metal-binding site 698968005215 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 698968005216 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968005218 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 698968005219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968005220 HTH-like domain; Region: HTH_21; pfam13276 698968005221 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 698968005222 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 698968005223 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698968005224 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 698968005225 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 698968005226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005227 Walker A/P-loop; other site 698968005228 ATP binding site [chemical binding]; other site 698968005229 Q-loop/lid; other site 698968005230 ABC transporter signature motif; other site 698968005231 Walker B; other site 698968005232 D-loop; other site 698968005233 H-loop/switch region; other site 698968005234 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 698968005235 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005236 Walker A/P-loop; other site 698968005237 ATP binding site [chemical binding]; other site 698968005238 Q-loop/lid; other site 698968005239 ABC transporter signature motif; other site 698968005240 Walker B; other site 698968005241 D-loop; other site 698968005242 H-loop/switch region; other site 698968005243 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 698968005244 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 698968005245 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 698968005246 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 698968005247 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 698968005248 FMN binding site [chemical binding]; other site 698968005249 active site 698968005250 catalytic residues [active] 698968005251 substrate binding site [chemical binding]; other site 698968005252 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 698968005253 PhoU domain; Region: PhoU; pfam01895 698968005254 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 698968005255 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 698968005256 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968005257 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968005258 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 698968005259 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 698968005260 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 698968005261 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 698968005262 heme-binding site [chemical binding]; other site 698968005263 potential frameshift: common BLAST hit: gi|38234483|ref|NP_940250.1| 4-amino-4-deoxychorismate lyase 698968005264 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 698968005265 substrate-cofactor binding pocket; other site 698968005266 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 698968005267 substrate binding site [chemical binding]; other site 698968005268 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 698968005269 homodimer interface [polypeptide binding]; other site 698968005270 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 698968005271 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 698968005272 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 698968005273 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 698968005274 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 698968005275 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 698968005276 dimerization interface [polypeptide binding]; other site 698968005277 putative ATP binding site [chemical binding]; other site 698968005278 amidophosphoribosyltransferase; Provisional; Region: PRK07847 698968005279 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 698968005280 active site 698968005281 tetramer interface [polypeptide binding]; other site 698968005282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005283 active site 698968005284 Haemolysin-III related; Region: HlyIII; cl03831 698968005285 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698968005286 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 698968005287 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 698968005288 dimer interface [polypeptide binding]; other site 698968005289 putative radical transfer pathway; other site 698968005290 diiron center [ion binding]; other site 698968005291 tyrosyl radical; other site 698968005292 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 698968005293 catalytic residues [active] 698968005294 dimer interface [polypeptide binding]; other site 698968005295 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 698968005296 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005297 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 698968005298 ATP binding site [chemical binding]; other site 698968005299 active site 698968005300 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 698968005301 substrate binding site [chemical binding]; other site 698968005302 adenylosuccinate lyase; Region: purB; TIGR00928 698968005303 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 698968005304 tetramer interface [polypeptide binding]; other site 698968005305 aspartate aminotransferase; Provisional; Region: PRK05764 698968005306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968005307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968005308 homodimer interface [polypeptide binding]; other site 698968005309 catalytic residue [active] 698968005310 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 698968005311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968005312 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 698968005313 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 698968005314 Cation transport protein; Region: TrkH; cl10514 698968005315 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 698968005316 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 698968005317 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968005318 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 698968005319 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 698968005320 nucleotide binding site/active site [active] 698968005321 HIT family signature motif; other site 698968005322 catalytic residue [active] 698968005323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005324 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 698968005326 dimerization interface [polypeptide binding]; other site 698968005327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 698968005328 dimer interface [polypeptide binding]; other site 698968005329 phosphorylation site [posttranslational modification] 698968005330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968005331 ATP binding site [chemical binding]; other site 698968005332 Mg2+ binding site [ion binding]; other site 698968005333 G-X-G motif; other site 698968005334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 698968005335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968005336 active site 698968005337 phosphorylation site [posttranslational modification] 698968005338 intermolecular recognition site; other site 698968005339 dimerization interface [polypeptide binding]; other site 698968005340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 698968005341 DNA binding site [nucleotide binding] 698968005342 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 698968005343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968005344 putative substrate translocation pore; other site 698968005345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968005346 Helix-turn-helix domains; Region: HTH; cl00088 698968005347 xanthine permease; Region: pbuX; TIGR03173 698968005348 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 698968005349 pyruvate dehydrogenase; Provisional; Region: PRK06546 698968005350 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 698968005351 PYR/PP interface [polypeptide binding]; other site 698968005352 dimer interface [polypeptide binding]; other site 698968005353 tetramer interface [polypeptide binding]; other site 698968005354 TPP binding site [chemical binding]; other site 698968005355 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 698968005356 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 698968005357 TPP-binding site [chemical binding]; other site 698968005358 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698968005359 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698968005360 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698968005361 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698968005362 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698968005363 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 698968005364 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 698968005365 active site 698968005366 homotetramer interface [polypeptide binding]; other site 698968005367 META domain; Region: META; cl01245 698968005368 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 698968005369 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698968005370 Transcriptional regulators [Transcription]; Region: PurR; COG1609 698968005371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 698968005372 DNA binding site [nucleotide binding] 698968005373 domain linker motif; other site 698968005374 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 698968005375 putative dimerization interface [polypeptide binding]; other site 698968005376 putative ligand binding site [chemical binding]; other site 698968005377 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 698968005378 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 698968005379 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698968005380 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 698968005381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968005382 active site 698968005383 HIGH motif; other site 698968005384 nucleotide binding site [chemical binding]; other site 698968005385 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 698968005386 KMSKS motif; other site 698968005387 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 698968005388 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 698968005389 homotrimer interaction site [polypeptide binding]; other site 698968005390 zinc binding site [ion binding]; other site 698968005391 CDP-binding sites; other site 698968005392 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 698968005393 substrate binding site; other site 698968005394 dimer interface; other site 698968005395 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 698968005396 DNA repair protein RadA; Provisional; Region: PRK11823 698968005397 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005398 Walker A motif; other site 698968005399 ATP binding site [chemical binding]; other site 698968005400 Walker B motif; other site 698968005401 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 698968005402 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 698968005403 active site clefts [active] 698968005404 zinc binding site [ion binding]; other site 698968005405 dimer interface [polypeptide binding]; other site 698968005406 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 698968005407 endonuclease III; Region: ENDO3c; smart00478 698968005408 minor groove reading motif; other site 698968005409 helix-hairpin-helix signature motif; other site 698968005410 substrate binding pocket [chemical binding]; other site 698968005411 active site 698968005412 Uncharacterized conserved protein [Function unknown]; Region: COG2966 698968005413 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698968005414 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 698968005415 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 698968005416 Clp protease ATP binding subunit; Region: clpC; CHL00095 698968005417 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005418 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005420 Walker A motif; other site 698968005421 ATP binding site [chemical binding]; other site 698968005422 Walker B motif; other site 698968005423 arginine finger; other site 698968005424 UvrB/uvrC motif; Region: UVR; pfam02151 698968005425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005426 Walker A motif; other site 698968005427 ATP binding site [chemical binding]; other site 698968005428 Walker B motif; other site 698968005429 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698968005430 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005431 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 698968005432 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 698968005433 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698968005434 dimer interface [polypeptide binding]; other site 698968005435 putative anticodon binding site; other site 698968005436 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698968005437 motif 1; other site 698968005438 active site 698968005439 motif 2; other site 698968005440 motif 3; other site 698968005441 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005442 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 698968005443 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968005444 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698968005445 Walker A/P-loop; other site 698968005446 ATP binding site [chemical binding]; other site 698968005447 Q-loop/lid; other site 698968005448 ABC transporter signature motif; other site 698968005449 Walker B; other site 698968005450 D-loop; other site 698968005451 H-loop/switch region; other site 698968005452 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 698968005453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 698968005454 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698968005455 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 698968005456 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968005457 active site 698968005458 KMSKS motif; other site 698968005459 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 698968005460 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 698968005461 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 698968005462 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 698968005463 catalytic center binding site [active] 698968005464 ATP binding site [chemical binding]; other site 698968005465 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 698968005466 homooctamer interface [polypeptide binding]; other site 698968005467 active site 698968005468 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 698968005469 dihydropteroate synthase; Region: DHPS; TIGR01496 698968005470 substrate binding pocket [chemical binding]; other site 698968005471 dimer interface [polypeptide binding]; other site 698968005472 inhibitor binding site; inhibition site 698968005473 Protein of unknown function, DUF393; Region: DUF393; cl01136 698968005474 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 698968005475 homodecamer interface [polypeptide binding]; other site 698968005476 GTP cyclohydrolase I; Provisional; Region: PLN03044 698968005477 active site 698968005478 putative catalytic site residues [active] 698968005479 zinc binding site [ion binding]; other site 698968005480 GTP-CH-I/GFRP interaction surface; other site 698968005481 FtsH Extracellular; Region: FtsH_ext; pfam06480 698968005482 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 698968005483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005484 Walker A motif; other site 698968005485 ATP binding site [chemical binding]; other site 698968005486 Walker B motif; other site 698968005487 arginine finger; other site 698968005488 Peptidase family M41; Region: Peptidase_M41; pfam01434 698968005489 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 698968005490 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005491 active site 698968005492 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 698968005493 Ligand Binding Site [chemical binding]; other site 698968005494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968005495 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 698968005496 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 698968005497 dimer interface [polypeptide binding]; other site 698968005498 substrate binding site [chemical binding]; other site 698968005499 metal binding sites [ion binding]; metal-binding site 698968005500 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 698968005501 active site residue [active] 698968005502 Transcriptional regulators [Transcription]; Region: MarR; COG1846 698968005503 Helix-turn-helix domains; Region: HTH; cl00088 698968005504 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 698968005505 AMP-binding enzyme; Region: AMP-binding; cl15778 698968005506 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005507 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 698968005508 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968005509 putative trimer interface [polypeptide binding]; other site 698968005510 putative CoA binding site [chemical binding]; other site 698968005511 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 698968005512 putative trimer interface [polypeptide binding]; other site 698968005513 putative CoA binding site [chemical binding]; other site 698968005514 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 698968005515 metal ion-dependent adhesion site (MIDAS); other site 698968005516 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 698968005517 active site 698968005518 catalytic site [active] 698968005519 Fibronectin type III-like domain; Region: Fn3-like; cl15273 698968005520 Secretory lipase; Region: LIP; pfam03583 698968005521 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 698968005522 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 698968005523 Helix-turn-helix domains; Region: HTH; cl00088 698968005524 Helix-turn-helix domains; Region: HTH; cl00088 698968005525 putative transposase OrfB; Reviewed; Region: PHA02517 698968005526 HTH-like domain; Region: HTH_21; pfam13276 698968005527 Integrase core domain; Region: rve; cl01316 698968005528 Integrase core domain; Region: rve_3; cl15866 698968005529 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 698968005530 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 698968005531 ring oligomerisation interface [polypeptide binding]; other site 698968005532 ATP/Mg binding site [chemical binding]; other site 698968005533 stacking interactions; other site 698968005534 hinge regions; other site 698968005535 Fic/DOC family; Region: Fic; cl00960 698968005536 Fic family protein [Function unknown]; Region: COG3177 698968005537 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 698968005538 hypothetical protein; Reviewed; Region: PRK09588 698968005539 potential frameshift: common BLAST hit: gi|172041596|ref|YP_001801310.1| transposase for insertion sequence 698968005540 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968005541 MULE transposase domain; Region: MULE; pfam10551 698968005542 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 698968005543 FMN binding site [chemical binding]; other site 698968005544 active site 698968005545 substrate binding site [chemical binding]; other site 698968005546 catalytic residue [active] 698968005547 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 698968005548 DNA topoisomerase III; Validated; Region: PRK08173 698968005549 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 698968005550 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 698968005551 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005552 Walker A/P-loop; other site 698968005553 ATP binding site [chemical binding]; other site 698968005554 Q-loop/lid; other site 698968005555 ABC transporter signature motif; other site 698968005556 Walker B; other site 698968005557 D-loop; other site 698968005558 H-loop/switch region; other site 698968005559 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005560 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 698968005561 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 698968005562 amidohydrolase; Region: amidohydrolases; TIGR01891 698968005563 metal binding site [ion binding]; metal-binding site 698968005564 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 698968005565 AAA domain; Region: AAA_21; pfam13304 698968005566 Restriction endonuclease [Defense mechanisms]; Region: COG3587 698968005567 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968005570 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005571 endonuclease III; Region: ENDO3c; smart00478 698968005572 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005573 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005574 DEAD-like helicases superfamily; Region: DEXDc; smart00487 698968005575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968005576 ATP binding site [chemical binding]; other site 698968005577 putative Mg++ binding site [ion binding]; other site 698968005578 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 698968005579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 698968005580 nucleotide binding region [chemical binding]; other site 698968005581 ATP-binding site [chemical binding]; other site 698968005582 Abi-like protein; Region: Abi_2; cl01988 698968005583 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968005584 HipA N-terminal domain; Region: Couple_hipA; cl11853 698968005585 HipA-like N-terminal domain; Region: HipA_N; pfam07805 698968005586 HipA-like C-terminal domain; Region: HipA_C; pfam07804 698968005587 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 698968005588 HicB family; Region: HicB; pfam05534 698968005589 putative transposase OrfB; Reviewed; Region: PHA02517 698968005590 HTH-like domain; Region: HTH_21; pfam13276 698968005591 Integrase core domain; Region: rve; cl01316 698968005592 Integrase core domain; Region: rve_3; cl15866 698968005593 Helix-turn-helix domains; Region: HTH; cl00088 698968005594 chromosome segregation protein; Provisional; Region: PRK03918 698968005595 potential frameshift: common BLAST hit: gi|227832249|ref|YP_002833956.1| transposase 698968005596 MULE transposase domain; Region: MULE; pfam10551 698968005597 Transposase, Mutator family; Region: Transposase_mut; pfam00872 698968005598 MULE transposase domain; Region: MULE; pfam10551 698968005599 hypothetical protein; Provisional; Region: PRK07907 698968005600 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 698968005601 active site 698968005602 metal binding site [ion binding]; metal-binding site 698968005603 dimer interface [polypeptide binding]; other site 698968005604 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698968005605 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 698968005606 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 698968005607 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 698968005608 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 698968005609 active site 698968005610 catalytic residues [active] 698968005611 metal binding site [ion binding]; metal-binding site 698968005612 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 698968005613 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 698968005614 putative catalytic site [active] 698968005615 putative metal binding site [ion binding]; other site 698968005616 putative phosphate binding site [ion binding]; other site 698968005617 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 698968005618 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 698968005619 putative active site [active] 698968005620 catalytic site [active] 698968005621 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 698968005622 putative active site [active] 698968005623 catalytic site [active] 698968005624 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 698968005625 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968005626 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 698968005627 Walker A/P-loop; other site 698968005628 ATP binding site [chemical binding]; other site 698968005629 Q-loop/lid; other site 698968005630 ABC transporter signature motif; other site 698968005631 Walker B; other site 698968005632 D-loop; other site 698968005633 H-loop/switch region; other site 698968005634 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 698968005635 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 698968005636 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 698968005637 substrate binding pocket [chemical binding]; other site 698968005638 membrane-bound complex binding site; other site 698968005639 hinge residues; other site 698968005640 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 698968005641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 698968005642 active site 698968005643 ATP binding site [chemical binding]; other site 698968005644 substrate binding site [chemical binding]; other site 698968005645 activation loop (A-loop); other site 698968005646 acetate kinase; Region: ackA; TIGR00016 698968005647 Acetokinase family; Region: Acetate_kinase; cl01029 698968005648 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 698968005649 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 698968005650 ferredoxin-NADP+ reductase; Region: PLN02852 698968005651 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 698968005652 ATP-grasp domain; Region: ATP-grasp_4; cl03087 698968005653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005654 active site 698968005655 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968005656 putative active site [active] 698968005657 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 698968005658 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 698968005659 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 698968005660 GDP-binding site [chemical binding]; other site 698968005661 ACT binding site; other site 698968005662 IMP binding site; other site 698968005663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968005664 Fibronectin type III-like domain; Region: Fn3-like; cl15273 698968005665 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698968005666 Gram positive anchor; Region: Gram_pos_anchor; cl15427 698968005667 Predicted membrane protein [Function unknown]; Region: COG4129 698968005668 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 698968005669 chromosome segregation protein; Provisional; Region: PRK03918 698968005670 Predicted membrane protein [Function unknown]; Region: COG4129 698968005671 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 698968005672 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005673 endonuclease III; Region: ENDO3c; smart00478 698968005674 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005675 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 698968005676 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 698968005677 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 698968005678 Helix-turn-helix domains; Region: HTH; cl00088 698968005679 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 698968005680 GntP family permease; Region: GntP_permease; pfam02447 698968005681 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 698968005682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968005683 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 698968005684 Transcriptional regulators [Transcription]; Region: FadR; COG2186 698968005685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968005686 DNA-binding site [nucleotide binding]; DNA binding site 698968005687 FCD domain; Region: FCD; cl11656 698968005688 Transposase; Region: DEDD_Tnp_IS110; pfam01548 698968005689 endonuclease III; Region: ENDO3c; smart00478 698968005690 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 698968005691 potential frameshift: common BLAST hit: gi|68535552|ref|YP_250257.1| transposase IS3510c 698968005692 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698968005693 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698968005694 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 698968005695 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 698968005696 active site 698968005697 intersubunit interface [polypeptide binding]; other site 698968005698 zinc binding site [ion binding]; other site 698968005699 Na+ binding site [ion binding]; other site 698968005700 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 698968005701 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 698968005702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 698968005703 active site 698968005704 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 698968005705 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 698968005706 active site residue [active] 698968005707 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 698968005708 active site residue [active] 698968005709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968005710 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 698968005711 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005712 Clp amino terminal domain; Region: Clp_N; pfam02861 698968005713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005714 Walker A motif; other site 698968005715 ATP binding site [chemical binding]; other site 698968005716 Walker B motif; other site 698968005717 arginine finger; other site 698968005718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 698968005719 Walker A motif; other site 698968005720 ATP binding site [chemical binding]; other site 698968005721 Walker B motif; other site 698968005722 arginine finger; other site 698968005723 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 698968005724 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 698968005725 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 698968005726 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698968005727 Walker A/P-loop; other site 698968005728 ATP binding site [chemical binding]; other site 698968005729 Q-loop/lid; other site 698968005730 ABC transporter signature motif; other site 698968005731 Walker B; other site 698968005732 D-loop; other site 698968005733 H-loop/switch region; other site 698968005734 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 698968005735 EamA-like transporter family; Region: EamA; cl01037 698968005736 EamA-like transporter family; Region: EamA; cl01037 698968005737 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 698968005738 FAD binding pocket [chemical binding]; other site 698968005739 FAD binding motif [chemical binding]; other site 698968005740 phosphate binding motif [ion binding]; other site 698968005741 beta-alpha-beta structure motif; other site 698968005742 NAD binding pocket [chemical binding]; other site 698968005743 Predicted amidohydrolase [General function prediction only]; Region: COG0388 698968005744 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 698968005745 putative active site [active] 698968005746 catalytic triad [active] 698968005747 putative dimer interface [polypeptide binding]; other site 698968005748 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 698968005749 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 698968005750 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 698968005751 NAD binding site [chemical binding]; other site 698968005752 substrate binding site [chemical binding]; other site 698968005753 catalytic Zn binding site [ion binding]; other site 698968005754 tetramer interface [polypeptide binding]; other site 698968005755 structural Zn binding site [ion binding]; other site 698968005756 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698968005757 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968005758 NAD(P) binding site [chemical binding]; other site 698968005759 catalytic residues [active] 698968005760 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 698968005761 DNA binding residues [nucleotide binding] 698968005762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 698968005763 putative dimer interface [polypeptide binding]; other site 698968005764 chaperone protein DnaJ; Provisional; Region: PRK14279 698968005765 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 698968005766 HSP70 interaction site [polypeptide binding]; other site 698968005767 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 698968005768 Zn binding sites [ion binding]; other site 698968005769 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 698968005770 dimer interface [polypeptide binding]; other site 698968005771 heat shock protein GrpE; Provisional; Region: PRK14140 698968005772 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 698968005773 dimer interface [polypeptide binding]; other site 698968005774 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 698968005775 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 698968005776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 698968005777 putative active site [active] 698968005778 heme pocket [chemical binding]; other site 698968005779 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 698968005780 Domain of unknown function DUF20; Region: UPF0118; pfam01594 698968005781 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968005782 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968005783 Walker A/P-loop; other site 698968005784 ATP binding site [chemical binding]; other site 698968005785 Q-loop/lid; other site 698968005786 ABC transporter signature motif; other site 698968005787 Walker B; other site 698968005788 D-loop; other site 698968005789 H-loop/switch region; other site 698968005790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968005791 dimer interface [polypeptide binding]; other site 698968005792 conserved gate region; other site 698968005793 putative PBP binding loops; other site 698968005794 ABC-ATPase subunit interface; other site 698968005795 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968005796 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 698968005797 Walker A/P-loop; other site 698968005798 ATP binding site [chemical binding]; other site 698968005799 Q-loop/lid; other site 698968005800 ABC transporter signature motif; other site 698968005801 Walker B; other site 698968005802 D-loop; other site 698968005803 H-loop/switch region; other site 698968005804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 698968005805 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 698968005806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 698968005807 dimer interface [polypeptide binding]; other site 698968005808 conserved gate region; other site 698968005809 putative PBP binding loops; other site 698968005810 ABC-ATPase subunit interface; other site 698968005811 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 698968005812 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 698968005813 Phosphate transporter family; Region: PHO4; cl00396 698968005814 Phosphate transporter family; Region: PHO4; cl00396 698968005815 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 698968005816 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 698968005817 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 698968005818 dimerization interface [polypeptide binding]; other site 698968005819 ATP binding site [chemical binding]; other site 698968005820 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 698968005821 dimerization interface [polypeptide binding]; other site 698968005822 ATP binding site [chemical binding]; other site 698968005823 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 698968005824 putative active site [active] 698968005825 catalytic triad [active] 698968005826 nucleosidase; Provisional; Region: PRK05634 698968005827 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 698968005828 ferredoxin-NADP+ reductase; Region: PLN02852 698968005829 Permease; Region: Permease; cl00510 698968005830 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 698968005831 4Fe-4S binding domain; Region: Fer4; cl02805 698968005832 Cysteine-rich domain; Region: CCG; pfam02754 698968005833 Cysteine-rich domain; Region: CCG; pfam02754 698968005834 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 698968005835 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 698968005836 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 698968005837 putative NAD(P) binding site [chemical binding]; other site 698968005838 catalytic Zn binding site [ion binding]; other site 698968005839 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 698968005840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 698968005841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968005842 homodimer interface [polypeptide binding]; other site 698968005843 catalytic residue [active] 698968005844 YibE/F-like protein; Region: YibE_F; cl02259 698968005845 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 698968005846 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 698968005847 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 698968005848 dimer interface [polypeptide binding]; other site 698968005849 putative anticodon binding site; other site 698968005850 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 698968005851 motif 1; other site 698968005852 active site 698968005853 motif 2; other site 698968005854 motif 3; other site 698968005855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 698968005856 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 698968005857 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005858 Protein of unknown function (DUF998); Region: DUF998; pfam06197 698968005859 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 698968005860 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 698968005861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968005862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 698968005863 trimer interface [polypeptide binding]; other site 698968005864 active site 698968005865 BRO family, N-terminal domain; Region: Bro-N; cl10591 698968005866 Abi-like protein; Region: Abi_2; cl01988 698968005867 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 698968005868 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968005869 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 698968005870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005871 Walker A/P-loop; other site 698968005872 ATP binding site [chemical binding]; other site 698968005873 Q-loop/lid; other site 698968005874 ABC transporter signature motif; other site 698968005875 Walker B; other site 698968005876 D-loop; other site 698968005877 H-loop/switch region; other site 698968005878 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 698968005879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005880 Walker A/P-loop; other site 698968005881 ATP binding site [chemical binding]; other site 698968005882 Q-loop/lid; other site 698968005883 ABC transporter signature motif; other site 698968005884 Walker B; other site 698968005885 D-loop; other site 698968005886 H-loop/switch region; other site 698968005887 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698968005888 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 698968005889 active site 698968005890 Acyl transferase domain; Region: Acyl_transf_1; cl08282 698968005891 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005892 Condensation domain; Region: Condensation; pfam00668 698968005893 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968005894 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968005895 Condensation domain; Region: Condensation; pfam00668 698968005896 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968005897 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968005898 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 698968005899 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005900 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005901 peptide synthase; Provisional; Region: PRK12467 698968005902 Condensation domain; Region: Condensation; pfam00668 698968005903 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968005904 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968005905 AMP-binding enzyme; Region: AMP-binding; cl15778 698968005906 Condensation domain; Region: Condensation; pfam00668 698968005907 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 698968005908 Nonribosomal peptide synthase; Region: NRPS; pfam08415 698968005909 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005910 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 698968005911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968005912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 698968005913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 698968005914 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 698968005915 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 698968005916 Walker A/P-loop; other site 698968005917 ATP binding site [chemical binding]; other site 698968005918 Q-loop/lid; other site 698968005919 ABC transporter signature motif; other site 698968005920 Walker B; other site 698968005921 D-loop; other site 698968005922 H-loop/switch region; other site 698968005923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968005924 Walker A/P-loop; other site 698968005925 ATP binding site [chemical binding]; other site 698968005926 Q-loop/lid; other site 698968005927 ABC transporter signature motif; other site 698968005928 Walker B; other site 698968005929 D-loop; other site 698968005930 H-loop/switch region; other site 698968005931 metabolite-proton symporter; Region: 2A0106; TIGR00883 698968005932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968005933 putative substrate translocation pore; other site 698968005934 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 698968005935 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 698968005936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968005937 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 698968005938 putative substrate translocation pore; other site 698968005939 YwiC-like protein; Region: YwiC; pfam14256 698968005940 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698968005941 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 698968005942 VanW like protein; Region: VanW; pfam04294 698968005943 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 698968005944 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 698968005945 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 698968005946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 698968005947 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 698968005948 Methyltransferase domain; Region: Methyltransf_31; pfam13847 698968005949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968005950 S-adenosylmethionine binding site [chemical binding]; other site 698968005951 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 698968005952 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 698968005953 active site 698968005954 substrate-binding site [chemical binding]; other site 698968005955 metal-binding site [ion binding] 698968005956 GTP binding site [chemical binding]; other site 698968005957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 698968005958 S-adenosylmethionine binding site [chemical binding]; other site 698968005959 LabA_like proteins; Region: LabA_like; cd06167 698968005960 putative metal binding site [ion binding]; other site 698968005961 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 698968005962 Predicted integral membrane protein [Function unknown]; Region: COG0392 698968005963 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 698968005964 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 698968005965 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 698968005966 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 698968005967 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 698968005968 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968005969 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 698968005970 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005971 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 698968005972 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 698968005973 active site 698968005974 Acyl transferase domain; Region: Acyl_transf_1; cl08282 698968005975 Phosphopantetheine attachment site; Region: PP-binding; cl09936 698968005976 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 698968005977 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 698968005978 AMP-binding enzyme; Region: AMP-binding; cl15778 698968005979 Cutinase; Region: Cutinase; pfam01083 698968005980 Predicted esterase [General function prediction only]; Region: COG0627 698968005981 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005982 LGFP repeat; Region: LGFP; pfam08310 698968005983 LGFP repeat; Region: LGFP; pfam08310 698968005984 LGFP repeat; Region: LGFP; pfam08310 698968005985 Predicted esterase [General function prediction only]; Region: COG0627 698968005986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968005987 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 698968005988 UbiA prenyltransferase family; Region: UbiA; cl00337 698968005989 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 698968005990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 698968005991 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 698968005992 active site 698968005993 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 698968005994 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968005995 NAD(P) binding site [chemical binding]; other site 698968005996 catalytic residues [active] 698968005997 BCCT family transporter; Region: BCCT; cl00569 698968005998 choline dehydrogenase; Validated; Region: PRK02106 698968005999 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 698968006000 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 698968006001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968006002 UDP-galactopyranose mutase; Region: GLF; pfam03275 698968006003 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 698968006004 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006005 ABC transporter signature motif; other site 698968006006 Walker B; other site 698968006007 D-loop; other site 698968006008 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 698968006009 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 698968006010 amidase catalytic site [active] 698968006011 Zn binding residues [ion binding]; other site 698968006012 substrate binding site [chemical binding]; other site 698968006013 LGFP repeat; Region: LGFP; pfam08310 698968006014 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 698968006015 HTH-like domain; Region: HTH_21; pfam13276 698968006016 Integrase core domain; Region: rve; cl01316 698968006017 Protein P3 of Potyviral polyprotein; Region: Potyvirid-P3; pfam13608 698968006018 glycerol kinase; Provisional; Region: glpK; PRK00047 698968006019 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 698968006020 N- and C-terminal domain interface [polypeptide binding]; other site 698968006021 active site 698968006022 MgATP binding site [chemical binding]; other site 698968006023 catalytic site [active] 698968006024 metal binding site [ion binding]; metal-binding site 698968006025 carbohydrate binding site [chemical binding]; other site 698968006026 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 698968006027 amphipathic channel; other site 698968006028 Asn-Pro-Ala signature motifs; other site 698968006029 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698968006030 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 698968006031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 698968006032 putative acyl-acceptor binding pocket; other site 698968006033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968006034 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 698968006035 active site 698968006036 motif I; other site 698968006037 motif II; other site 698968006038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 698968006039 seryl-tRNA synthetase; Provisional; Region: PRK05431 698968006040 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 698968006041 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 698968006042 dimer interface [polypeptide binding]; other site 698968006043 active site 698968006044 motif 1; other site 698968006045 motif 2; other site 698968006046 motif 3; other site 698968006047 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 698968006048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968006049 DNA-binding site [nucleotide binding]; DNA binding site 698968006050 UTRA domain; Region: UTRA; cl01230 698968006051 Septum formation; Region: Septum_form; pfam13845 698968006052 Septum formation; Region: Septum_form; pfam13845 698968006053 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 698968006054 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 698968006055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 698968006057 catalytic core [active] 698968006058 prephenate dehydratase; Provisional; Region: PRK11898 698968006059 Prephenate dehydratase; Region: PDT; pfam00800 698968006060 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 698968006061 putative L-Phe binding site [chemical binding]; other site 698968006062 Amidase; Region: Amidase; cl11426 698968006063 CAAX protease self-immunity; Region: Abi; cl00558 698968006064 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 698968006065 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 698968006066 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 698968006067 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 698968006068 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 698968006069 OpgC protein; Region: OpgC_C; cl00792 698968006070 Acyltransferase family; Region: Acyl_transf_3; pfam01757 698968006071 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 698968006072 catalytic triad [active] 698968006073 catalytic triad [active] 698968006074 oxyanion hole [active] 698968006075 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 698968006076 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 698968006077 putative active site [active] 698968006078 catalytic site [active] 698968006079 putative metal binding site [ion binding]; other site 698968006080 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 698968006081 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 698968006082 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968006083 NAD binding site [chemical binding]; other site 698968006084 dimer interface [polypeptide binding]; other site 698968006085 substrate binding site [chemical binding]; other site 698968006086 Quinolinate synthetase A protein; Region: NadA; cl00420 698968006087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 698968006088 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 698968006089 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 698968006090 dimerization interface [polypeptide binding]; other site 698968006091 active site 698968006092 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 698968006093 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 698968006094 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 698968006095 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 698968006096 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698968006097 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 698968006098 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 698968006099 Lsr2; Region: Lsr2; pfam11774 698968006100 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968006101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968006102 active site 698968006103 phosphorylation site [posttranslational modification] 698968006104 intermolecular recognition site; other site 698968006105 dimerization interface [polypeptide binding]; other site 698968006106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968006107 DNA binding residues [nucleotide binding] 698968006108 dimerization interface [polypeptide binding]; other site 698968006109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 698968006110 Histidine kinase; Region: HisKA_3; pfam07730 698968006111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 698968006112 ATP binding site [chemical binding]; other site 698968006113 Mg2+ binding site [ion binding]; other site 698968006114 G-X-G motif; other site 698968006115 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 698968006116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006118 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 698968006119 active site 698968006120 catalytic site [active] 698968006121 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 698968006122 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698968006123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 698968006124 Helix-turn-helix domains; Region: HTH; cl00088 698968006125 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006126 Ligand Binding Site [chemical binding]; other site 698968006127 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006128 Ligand Binding Site [chemical binding]; other site 698968006129 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 698968006130 probable active site [active] 698968006131 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 698968006132 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 698968006133 Walker A/P-loop; other site 698968006134 ATP binding site [chemical binding]; other site 698968006135 Q-loop/lid; other site 698968006136 ABC transporter signature motif; other site 698968006137 Walker B; other site 698968006138 D-loop; other site 698968006139 H-loop/switch region; other site 698968006140 Predicted transcriptional regulators [Transcription]; Region: COG1725 698968006141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 698968006142 DNA-binding site [nucleotide binding]; DNA binding site 698968006143 LabA_like proteins; Region: LabA_like; cd06167 698968006144 putative metal binding site [ion binding]; other site 698968006145 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 698968006146 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698968006147 catalytic residues [active] 698968006148 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698968006149 metal-binding site [ion binding] 698968006150 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 698968006151 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 698968006152 metal-binding site [ion binding] 698968006153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 698968006154 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 698968006155 benzoate transport; Region: 2A0115; TIGR00895 698968006156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006157 putative substrate translocation pore; other site 698968006158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 698968006159 replicative DNA helicase; Provisional; Region: PRK05636 698968006160 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 698968006161 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 698968006162 Walker A motif; other site 698968006163 ATP binding site [chemical binding]; other site 698968006164 Walker B motif; other site 698968006165 DNA binding loops [nucleotide binding] 698968006166 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 698968006167 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 698968006168 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 698968006169 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 698968006170 dimer interface [polypeptide binding]; other site 698968006171 ssDNA binding site [nucleotide binding]; other site 698968006172 tetramer (dimer of dimers) interface [polypeptide binding]; other site 698968006173 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 698968006174 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 698968006175 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 698968006176 Transglycosylase; Region: Transgly; cl07896 698968006177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 698968006178 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 698968006179 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006180 Ligand Binding Site [chemical binding]; other site 698968006181 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 698968006182 Ligand Binding Site [chemical binding]; other site 698968006183 classical (c) SDRs; Region: SDR_c; cd05233 698968006184 NAD(P) binding site [chemical binding]; other site 698968006185 active site 698968006186 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698968006187 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698968006188 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 698968006189 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 698968006190 active site residue [active] 698968006191 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 698968006192 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 698968006193 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 698968006194 dimerization interface [polypeptide binding]; other site 698968006195 DPS ferroxidase diiron center [ion binding]; other site 698968006196 ion pore; other site 698968006197 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 698968006198 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 698968006199 putative DNA binding site [nucleotide binding]; other site 698968006200 catalytic residue [active] 698968006201 putative H2TH interface [polypeptide binding]; other site 698968006202 putative catalytic residues [active] 698968006203 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 698968006204 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 698968006205 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 698968006206 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 698968006207 putative substrate binding site [chemical binding]; other site 698968006208 putative ATP binding site [chemical binding]; other site 698968006209 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 698968006210 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 698968006211 active site 698968006212 VanZ like family; Region: VanZ; cl01971 698968006213 AAA domain; Region: AAA_31; pfam13614 698968006214 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006215 P-loop; other site 698968006216 Magnesium ion binding site [ion binding]; other site 698968006217 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006218 Magnesium ion binding site [ion binding]; other site 698968006219 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698968006220 Divergent AAA domain; Region: AAA_4; pfam04326 698968006221 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698968006222 Divergent AAA domain; Region: AAA_4; pfam04326 698968006223 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 698968006224 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 698968006225 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 698968006226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 698968006227 ATP binding site [chemical binding]; other site 698968006228 putative Mg++ binding site [ion binding]; other site 698968006229 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 698968006230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968006231 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 698968006232 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 698968006233 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006234 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006235 ATP binding site [chemical binding]; other site 698968006236 putative Mg++ binding site [ion binding]; other site 698968006237 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 698968006238 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 698968006239 HsdM N-terminal domain; Region: HsdM_N; pfam12161 698968006240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968006241 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 698968006242 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 698968006243 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 698968006244 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698968006245 DNA binding residues [nucleotide binding] 698968006246 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 698968006247 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 698968006248 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 698968006249 Uncharacterized conserved protein [Function unknown]; Region: COG3410 698968006250 Fic family protein [Function unknown]; Region: COG3177 698968006251 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 698968006252 Fic/DOC family; Region: Fic; cl00960 698968006253 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 698968006254 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 698968006255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006256 Walker A/P-loop; other site 698968006257 ATP binding site [chemical binding]; other site 698968006258 Q-loop/lid; other site 698968006259 ABC transporter signature motif; other site 698968006260 Walker B; other site 698968006261 D-loop; other site 698968006262 H-loop/switch region; other site 698968006263 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 698968006264 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 698968006265 E-class dimer interface [polypeptide binding]; other site 698968006266 P-class dimer interface [polypeptide binding]; other site 698968006267 active site 698968006268 Cu2+ binding site [ion binding]; other site 698968006269 Zn2+ binding site [ion binding]; other site 698968006270 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 698968006271 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968006272 active site 698968006273 HIGH motif; other site 698968006274 nucleotide binding site [chemical binding]; other site 698968006275 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 698968006276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968006277 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 698968006278 active site 698968006279 KMSKS motif; other site 698968006280 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 698968006281 tRNA binding surface [nucleotide binding]; other site 698968006282 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 698968006283 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 698968006284 Walker A/P-loop; other site 698968006285 ATP binding site [chemical binding]; other site 698968006286 Q-loop/lid; other site 698968006287 ABC transporter signature motif; other site 698968006288 Walker B; other site 698968006289 D-loop; other site 698968006290 H-loop/switch region; other site 698968006291 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 698968006292 Histidine kinase; Region: HisKA_3; pfam07730 698968006293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 698968006294 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 698968006295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 698968006296 active site 698968006297 phosphorylation site [posttranslational modification] 698968006298 intermolecular recognition site; other site 698968006299 dimerization interface [polypeptide binding]; other site 698968006300 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 698968006301 DNA binding residues [nucleotide binding] 698968006302 VanZ like family; Region: VanZ; cl01971 698968006303 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 698968006304 Predicted membrane protein [Function unknown]; Region: COG1511 698968006305 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968006306 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968006307 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 698968006308 ABC-2 type transporter; Region: ABC2_membrane; cl11417 698968006309 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 698968006310 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 698968006311 NAD(P) binding site [chemical binding]; other site 698968006312 catalytic residues [active] 698968006313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 698968006314 active site 698968006315 phosphorylation site [posttranslational modification] 698968006316 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 698968006317 active site 698968006318 P-loop; other site 698968006319 phosphorylation site [posttranslational modification] 698968006320 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 698968006321 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 698968006322 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 698968006323 DAK2 domain; Region: Dak2; cl03685 698968006324 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 698968006325 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 698968006326 dimerization domain swap beta strand [polypeptide binding]; other site 698968006327 regulatory protein interface [polypeptide binding]; other site 698968006328 active site 698968006329 regulatory phosphorylation site [posttranslational modification]; other site 698968006330 AAA domain; Region: AAA_21; pfam13304 698968006331 AAA domain; Region: AAA_21; pfam13304 698968006332 Predicted esterase [General function prediction only]; Region: COG0627 698968006333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 698968006334 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 698968006335 active site 698968006336 Cobalt transport protein; Region: CbiQ; cl00463 698968006337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006338 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 698968006339 ABC transporter signature motif; other site 698968006340 Walker B; other site 698968006341 D-loop; other site 698968006342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006343 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 698968006344 Walker A/P-loop; other site 698968006345 ATP binding site [chemical binding]; other site 698968006346 Q-loop/lid; other site 698968006347 ABC transporter signature motif; other site 698968006348 Walker B; other site 698968006349 D-loop; other site 698968006350 H-loop/switch region; other site 698968006351 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 698968006352 active site 698968006353 catalytic residues [active] 698968006354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 698968006355 hypothetical protein; Provisional; Region: PRK13663 698968006356 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 698968006357 putative active site [active] 698968006358 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 698968006359 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 698968006360 SdpI/YhfL protein family; Region: SdpI; pfam13630 698968006361 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698968006362 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 698968006363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968006364 catalytic residue [active] 698968006365 anthranilate synthase component I; Provisional; Region: PRK13564 698968006366 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 698968006367 chorismate binding enzyme; Region: Chorismate_bind; cl10555 698968006368 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 698968006369 Glutamine amidotransferase class-I; Region: GATase; pfam00117 698968006370 glutamine binding [chemical binding]; other site 698968006371 catalytic triad [active] 698968006372 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 698968006373 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 698968006374 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 698968006375 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 698968006376 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 698968006377 active site 698968006378 ribulose/triose binding site [chemical binding]; other site 698968006379 phosphate binding site [ion binding]; other site 698968006380 substrate (anthranilate) binding pocket [chemical binding]; other site 698968006381 product (indole) binding pocket [chemical binding]; other site 698968006382 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 698968006383 active site 698968006384 Protein of unknown function (DUF454); Region: DUF454; cl01063 698968006385 pantoate--beta-alanine ligase; Region: panC; TIGR00018 698968006386 Pantoate-beta-alanine ligase; Region: PanC; cd00560 698968006387 active site 698968006388 ATP-binding site [chemical binding]; other site 698968006389 pantoate-binding site; other site 698968006390 HXXH motif; other site 698968006391 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 698968006392 oligomerization interface [polypeptide binding]; other site 698968006393 active site 698968006394 metal binding site [ion binding]; metal-binding site 698968006395 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 698968006396 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 698968006397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 698968006398 catalytic residue [active] 698968006399 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 698968006400 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 698968006401 substrate binding site [chemical binding]; other site 698968006402 active site 698968006403 catalytic residues [active] 698968006404 heterodimer interface [polypeptide binding]; other site 698968006405 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 698968006406 iron-sulfur cluster [ion binding]; other site 698968006407 [2Fe-2S] cluster binding site [ion binding]; other site 698968006408 Membrane transport protein; Region: Mem_trans; cl09117 698968006409 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 698968006410 AzlC protein; Region: AzlC; cl00570 698968006411 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 698968006412 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 698968006413 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 698968006414 active site 698968006415 NTP binding site [chemical binding]; other site 698968006416 metal binding triad [ion binding]; metal-binding site 698968006417 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 698968006418 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 698968006419 Zn2+ binding site [ion binding]; other site 698968006420 Mg2+ binding site [ion binding]; other site 698968006421 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 698968006422 active site 698968006423 Ap6A binding site [chemical binding]; other site 698968006424 nudix motif; other site 698968006425 metal binding site [ion binding]; metal-binding site 698968006426 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 698968006427 MatE; Region: MatE; cl10513 698968006428 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 698968006429 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 698968006430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 698968006431 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 698968006432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 698968006433 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 698968006434 catalytic residues [active] 698968006435 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 698968006436 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 698968006437 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 698968006438 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 698968006439 active site 698968006440 metal binding site [ion binding]; metal-binding site 698968006441 ParB-like partition proteins; Region: parB_part; TIGR00180 698968006442 ParB-like nuclease domain; Region: ParBc; cl02129 698968006443 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 698968006444 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 698968006445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 698968006446 Magnesium ion binding site [ion binding]; other site 698968006447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 698968006448 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 698968006449 Ribonuclease P; Region: Ribonuclease_P; cl00457 698968006450 Ribosomal protein L34; Region: Ribosomal_L34; cl00370