-- dump date 20120504_142741 -- class Genbank::misc_feature -- table misc_feature_note -- id note 196164000001 Predicted helicase [General function prediction only]; Region: COG4889 196164000002 TrwC relaxase; Region: TrwC; cl08490 196164000003 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 196164000004 ParA-like protein; Provisional; Region: PHA02518 196164000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164000006 P-loop; other site 196164000007 Magnesium ion binding site [ion binding]; other site 196164000008 ParG; Region: ParG; pfam09274 196164000009 Replicase family; Region: Replicase; pfam03090 196164000010 beta-amylase; Region: PLN02705 196164000011 Helix-turn-helix domains; Region: HTH; cl00088 196164000012 DNA-binding site [nucleotide binding]; DNA binding site 196164000013 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164000014 MULE transposase domain; Region: MULE; pfam10551 196164000015 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164000016 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164000017 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 196164000018 P-loop; other site 196164000019 Magnesium ion binding site [ion binding]; other site 196164000020 Replicase family; Region: Replicase; pfam03090 196164000021 Predicted helicase [General function prediction only]; Region: COG4889 196164000022 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164000023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164000024 Helix-turn-helix domains; Region: HTH; cl00088 196164000025 putative transposase OrfB; Reviewed; Region: PHA02517 196164000026 Integrase core domain; Region: rve; cl01316 196164000027 ABC-2 type transporter; Region: ABC2_membrane; cl11417 196164000028 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196164000029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000030 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 196164000031 Walker A/P-loop; other site 196164000032 ATP binding site [chemical binding]; other site 196164000033 Q-loop/lid; other site 196164000034 ABC transporter signature motif; other site 196164000035 Walker B; other site 196164000036 D-loop; other site 196164000037 H-loop/switch region; other site 196164000038 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164000039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164000040 active site 196164000041 phosphorylation site [posttranslational modification] 196164000042 intermolecular recognition site; other site 196164000043 dimerization interface [polypeptide binding]; other site 196164000044 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164000045 DNA binding residues [nucleotide binding] 196164000046 dimerization interface [polypeptide binding]; other site 196164000047 Histidine kinase; Region: HisKA_3; pfam07730 196164000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 196164000049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 196164000050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 196164000051 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 196164000052 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164000053 P-loop; other site 196164000054 Magnesium ion binding site [ion binding]; other site 196164000055 Replicase family; Region: Replicase; pfam03090 196164000056 transcription elongation factor regulatory protein; Validated; Region: PRK06342 196164000057 Helix-turn-helix domains; Region: HTH; cl00088 196164000058 Restriction endonuclease; Region: Mrr_cat; cl00747 196164000059 TrwC relaxase; Region: TrwC; cl08490 196164000060 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 196164000061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164000062 non-specific DNA binding site [nucleotide binding]; other site 196164000063 salt bridge; other site 196164000064 sequence-specific DNA binding site [nucleotide binding]; other site 196164000065 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 196164000066 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 196164000067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 196164000068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164000069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196164000070 Integrase core domain; Region: rve; cl01316 196164000071 Vitamin K epoxide reductase family; Region: VKOR; cl01729 196164000072 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196164000073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164000074 dimerization interface [polypeptide binding]; other site 196164000075 putative DNA binding site [nucleotide binding]; other site 196164000076 putative Zn2+ binding site [ion binding]; other site 196164000077 Peptidase family M23; Region: Peptidase_M23; pfam01551 196164000078 Copper resistance protein D; Region: CopD; cl00563 196164000079 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 196164000080 Bacterial Ig-like domain; Region: Big_5; cl01012 196164000081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164000082 dimerization interface [polypeptide binding]; other site 196164000083 putative DNA binding site [nucleotide binding]; other site 196164000084 putative Zn2+ binding site [ion binding]; other site 196164000085 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 196164000086 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164000087 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164000088 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 196164000089 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 196164000090 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164000091 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164000092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196164000093 Integrase core domain; Region: rve; cl01316 196164000094 Integrase core domain; Region: rve; cl01316 196164000095 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 196164000096 multiple promoter invertase; Provisional; Region: mpi; PRK13413 196164000097 catalytic residues [active] 196164000098 catalytic nucleophile [active] 196164000099 Presynaptic Site I dimer interface [polypeptide binding]; other site 196164000100 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 196164000101 Synaptic Flat tetramer interface [polypeptide binding]; other site 196164000102 Synaptic Site I dimer interface [polypeptide binding]; other site 196164000103 DNA binding site [nucleotide binding] 196164000104 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 196164000105 DNA-binding interface [nucleotide binding]; DNA binding site 196164000106 Integrase core domain; Region: rve; cl01316 196164000107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164000108 non-specific DNA binding site [nucleotide binding]; other site 196164000109 salt bridge; other site 196164000110 sequence-specific DNA binding site [nucleotide binding]; other site 196164000111 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196164000112 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164000113 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164000114 MULE transposase domain; Region: MULE; pfam10551 196164000115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 196164000116 Integrase core domain; Region: rve; cl01316 196164000117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164000118 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 196164000119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164000120 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 196164000121 Walker A motif; other site 196164000122 ATP binding site [chemical binding]; other site 196164000123 Walker B motif; other site 196164000124 arginine finger; other site 196164000125 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 196164000126 DnaA box-binding interface [nucleotide binding]; other site 196164000127 DNA polymerase III subunit beta; Validated; Region: PRK07761 196164000128 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 196164000129 putative DNA binding surface [nucleotide binding]; other site 196164000130 dimer interface [polypeptide binding]; other site 196164000131 beta-clamp/clamp loader binding surface; other site 196164000132 beta-clamp/translesion DNA polymerase binding surface; other site 196164000133 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 196164000134 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 196164000135 Walker A/P-loop; other site 196164000136 ATP binding site [chemical binding]; other site 196164000137 Q-loop/lid; other site 196164000138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000139 ABC transporter signature motif; other site 196164000140 Walker B; other site 196164000141 D-loop; other site 196164000142 H-loop/switch region; other site 196164000143 Protein of unknown function (DUF721); Region: DUF721; cl02324 196164000144 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 196164000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164000146 ATP binding site [chemical binding]; other site 196164000147 Mg2+ binding site [ion binding]; other site 196164000148 G-X-G motif; other site 196164000149 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 196164000150 anchoring element; other site 196164000151 dimer interface [polypeptide binding]; other site 196164000152 ATP binding site [chemical binding]; other site 196164000153 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 196164000154 active site 196164000155 putative metal-binding site [ion binding]; other site 196164000156 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 196164000157 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 196164000158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164000159 dimerization interface [polypeptide binding]; other site 196164000160 putative DNA binding site [nucleotide binding]; other site 196164000161 putative Zn2+ binding site [ion binding]; other site 196164000162 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 196164000163 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164000164 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164000165 Predicted membrane protein [Function unknown]; Region: COG2364 196164000166 DNA gyrase subunit A; Validated; Region: PRK05560 196164000167 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 196164000168 CAP-like domain; other site 196164000169 active site 196164000170 primary dimer interface [polypeptide binding]; other site 196164000171 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196164000172 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196164000173 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196164000174 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196164000175 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196164000176 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 196164000177 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 196164000178 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196164000179 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000180 Walker A/P-loop; other site 196164000181 ATP binding site [chemical binding]; other site 196164000182 Q-loop/lid; other site 196164000183 ABC transporter signature motif; other site 196164000184 Walker B; other site 196164000185 D-loop; other site 196164000186 H-loop/switch region; other site 196164000187 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164000188 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196164000189 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196164000190 DNA binding site [nucleotide binding] 196164000191 domain linker motif; other site 196164000192 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 196164000193 putative ligand binding site [chemical binding]; other site 196164000194 putative dimerization interface [polypeptide binding]; other site 196164000195 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 196164000196 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 196164000197 putative ligand binding site [chemical binding]; other site 196164000198 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 196164000199 TM-ABC transporter signature motif; other site 196164000200 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196164000201 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 196164000202 Walker A/P-loop; other site 196164000203 ATP binding site [chemical binding]; other site 196164000204 Q-loop/lid; other site 196164000205 ABC transporter signature motif; other site 196164000206 Walker B; other site 196164000207 D-loop; other site 196164000208 H-loop/switch region; other site 196164000209 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 196164000210 Amidase; Region: Amidase; cl11426 196164000211 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 196164000212 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 196164000213 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 196164000214 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 196164000215 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 196164000216 putative ligand binding site [chemical binding]; other site 196164000217 Helix-turn-helix domains; Region: HTH; cl00088 196164000218 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 196164000219 active site 196164000220 Rhomboid family; Region: Rhomboid; cl11446 196164000221 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 196164000222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 196164000223 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196164000224 active site 196164000225 ATP binding site [chemical binding]; other site 196164000226 substrate binding site [chemical binding]; other site 196164000227 activation loop (A-loop); other site 196164000228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 196164000229 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196164000230 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196164000231 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196164000232 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 196164000233 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196164000234 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 196164000235 active site 196164000236 ATP binding site [chemical binding]; other site 196164000237 substrate binding site [chemical binding]; other site 196164000238 activation loop (A-loop); other site 196164000239 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164000240 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 196164000241 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 196164000242 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 196164000243 active site 196164000244 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 196164000245 phosphopeptide binding site; other site 196164000246 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 196164000247 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 196164000248 phosphopeptide binding site; other site 196164000249 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164000250 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164000251 Abi-like protein; Region: Abi_2; cl01988 196164000252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196164000253 LabA_like proteins; Region: LabA_like; cd06167 196164000254 putative metal binding site [ion binding]; other site 196164000255 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164000256 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 196164000257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164000258 HsdM N-terminal domain; Region: HsdM_N; pfam12161 196164000259 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 196164000260 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196164000261 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 196164000262 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 196164000263 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 196164000264 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000265 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 196164000266 Integrase core domain; Region: rve; cl01316 196164000267 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 196164000268 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 196164000269 NAD binding site [chemical binding]; other site 196164000270 substrate binding site [chemical binding]; other site 196164000271 catalytic Zn binding site [ion binding]; other site 196164000272 tetramer interface [polypeptide binding]; other site 196164000273 structural Zn binding site [ion binding]; other site 196164000274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196164000275 active site residue [active] 196164000276 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196164000277 active site residue [active] 196164000278 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 196164000279 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 196164000280 putative homotetramer interface [polypeptide binding]; other site 196164000281 putative homodimer interface [polypeptide binding]; other site 196164000282 putative allosteric switch controlling residues; other site 196164000283 putative metal binding site [ion binding]; other site 196164000284 putative homodimer-homodimer interface [polypeptide binding]; other site 196164000285 Domain of unknown function DUF302; Region: DUF302; cl01364 196164000286 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196164000287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000288 NAD(P) binding site [chemical binding]; other site 196164000289 active site 196164000290 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 196164000291 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 196164000292 Helix-turn-helix domains; Region: HTH; cl00088 196164000293 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 196164000294 dimerization interface [polypeptide binding]; other site 196164000295 substrate binding pocket [chemical binding]; other site 196164000296 Fasciclin domain; Region: Fasciclin; cl02663 196164000297 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196164000298 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 196164000299 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 196164000300 two component system sensor kinase SsrB; Provisional; Region: PRK15369 196164000301 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164000302 hydroperoxidase II; Provisional; Region: katE; PRK11249 196164000303 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 196164000304 heme binding pocket [chemical binding]; other site 196164000305 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 196164000306 domain interactions; other site 196164000307 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 196164000308 MgtE intracellular N domain; Region: MgtE_N; cl15244 196164000309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 196164000310 Divalent cation transporter; Region: MgtE; cl00786 196164000311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196164000312 metal-binding site [ion binding] 196164000313 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 196164000314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164000315 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164000316 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 196164000317 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 196164000318 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 196164000319 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196164000320 NAD(P) binding site [chemical binding]; other site 196164000321 catalytic residues [active] 196164000322 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 196164000323 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 196164000324 Cl- selectivity filter; other site 196164000325 Cl- binding residues [ion binding]; other site 196164000326 pore gating glutamate residue; other site 196164000327 dimer interface [polypeptide binding]; other site 196164000328 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 196164000329 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 196164000330 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 196164000331 putative active site [active] 196164000332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000333 CAAX protease self-immunity; Region: Abi; cl00558 196164000334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000336 Domain of unknown function DUF222; Region: DUF222; pfam02720 196164000337 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196164000338 active site 196164000339 biotin synthase; Validated; Region: PRK06256 196164000340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164000341 FeS/SAM binding site; other site 196164000342 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 196164000343 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 196164000344 NAD-dependent deacetylase; Provisional; Region: PRK05333 196164000345 NAD+ binding site [chemical binding]; other site 196164000346 substrate binding site [chemical binding]; other site 196164000347 Zn binding site [ion binding]; other site 196164000348 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 196164000349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000350 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 196164000351 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000352 Helix-turn-helix domains; Region: HTH; cl00088 196164000353 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196164000355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164000356 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 196164000357 AMP nucleosidase; Provisional; Region: PRK08292 196164000358 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 196164000359 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 196164000360 Proline dehydrogenase; Region: Pro_dh; cl03282 196164000361 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 196164000362 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196164000363 Glutamate binding site [chemical binding]; other site 196164000364 NAD binding site [chemical binding]; other site 196164000365 catalytic residues [active] 196164000366 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 196164000367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196164000368 active site 196164000369 catalytic tetrad [active] 196164000370 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 196164000371 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000372 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 196164000373 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000374 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 196164000375 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 196164000376 amidohydrolase; Region: amidohydrolases; TIGR01891 196164000377 metal binding site [ion binding]; metal-binding site 196164000378 Domain of unknown function DUF; Region: DUF202; cl09954 196164000379 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 196164000380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164000381 catalytic core [active] 196164000382 Uncharacterized conserved protein [Function unknown]; Region: COG4127 196164000383 Restriction endonuclease; Region: Mrr_cat; cl00516 196164000384 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 196164000385 Pantoate-beta-alanine ligase; Region: PanC; cd00560 196164000386 active site 196164000387 ATP-binding site [chemical binding]; other site 196164000388 pantoate-binding site; other site 196164000389 HXXH motif; other site 196164000390 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 196164000391 oligomerization interface [polypeptide binding]; other site 196164000392 active site 196164000393 metal binding site [ion binding]; metal-binding site 196164000394 salicylate hydroxylase; Provisional; Region: PRK08163 196164000395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000396 Helix-turn-helix domains; Region: HTH; cl00088 196164000397 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 196164000398 active site 196164000399 DNA binding site [nucleotide binding] 196164000400 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 196164000401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164000402 motif II; other site 196164000403 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 196164000404 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 196164000405 trimer interface [polypeptide binding]; other site 196164000406 putative metal binding site [ion binding]; other site 196164000407 TM2 domain; Region: TM2; cl00984 196164000408 Helix-turn-helix domains; Region: HTH; cl00088 196164000409 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 196164000410 enterobactin exporter EntS; Provisional; Region: PRK10489 196164000411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164000412 putative substrate translocation pore; other site 196164000413 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 196164000414 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196164000415 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 196164000416 DXD motif; other site 196164000417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164000418 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 196164000419 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196164000420 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196164000421 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 196164000422 YibE/F-like protein; Region: YibE_F; cl02259 196164000423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164000424 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 196164000425 tetramerization interface [polypeptide binding]; other site 196164000426 active site 196164000427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805 196164000428 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 196164000429 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 196164000430 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 196164000431 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 196164000432 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 196164000433 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000434 putative Mg++ binding site [ion binding]; other site 196164000435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164000436 nucleotide binding region [chemical binding]; other site 196164000437 Helicase associated domain (HA2); Region: HA2; cl04503 196164000438 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 196164000439 maltose O-acetyltransferase; Provisional; Region: PRK10092 196164000440 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 196164000441 active site 196164000442 substrate binding site [chemical binding]; other site 196164000443 trimer interface [polypeptide binding]; other site 196164000444 CoA binding site [chemical binding]; other site 196164000445 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 196164000446 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 196164000447 LysE type translocator; Region: LysE; cl00565 196164000448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196164000449 RNA binding surface [nucleotide binding]; other site 196164000450 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 196164000451 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196164000452 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 196164000453 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 196164000454 active site 196164000455 DNA binding site [nucleotide binding] 196164000456 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 196164000457 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 196164000458 putative NAD(P) binding site [chemical binding]; other site 196164000459 putative substrate binding site [chemical binding]; other site 196164000460 catalytic Zn binding site [ion binding]; other site 196164000461 structural Zn binding site [ion binding]; other site 196164000462 dimer interface [polypeptide binding]; other site 196164000463 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 196164000464 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 196164000465 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 196164000466 active site 196164000467 Zn binding site [ion binding]; other site 196164000468 Protease prsW family; Region: PrsW-protease; cl15823 196164000469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164000470 putative substrate translocation pore; other site 196164000471 PAS domain S-box; Region: sensory_box; TIGR00229 196164000472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 196164000473 putative active site [active] 196164000474 heme pocket [chemical binding]; other site 196164000475 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 196164000476 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 196164000477 active site 196164000478 dimer interface [polypeptide binding]; other site 196164000479 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 196164000480 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 196164000481 active site 196164000482 FMN binding site [chemical binding]; other site 196164000483 substrate binding site [chemical binding]; other site 196164000484 3Fe-4S cluster binding site [ion binding]; other site 196164000485 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 196164000486 domain interface; other site 196164000487 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 196164000488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000489 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 196164000490 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 196164000491 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 196164000492 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 196164000493 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196164000494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000495 NAD(P) binding site [chemical binding]; other site 196164000496 active site 196164000497 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 196164000498 FAD binding domain; Region: FAD_binding_4; pfam01565 196164000499 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 196164000500 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 196164000501 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 196164000502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196164000503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164000504 dimer interface [polypeptide binding]; other site 196164000505 conserved gate region; other site 196164000506 ABC-ATPase subunit interface; other site 196164000507 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196164000508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000509 Walker A/P-loop; other site 196164000510 ATP binding site [chemical binding]; other site 196164000511 Q-loop/lid; other site 196164000512 ABC transporter signature motif; other site 196164000513 Walker B; other site 196164000514 D-loop; other site 196164000515 H-loop/switch region; other site 196164000516 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 196164000517 GtrA-like protein; Region: GtrA; cl00971 196164000518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 196164000519 MOSC domain; Region: MOSC; pfam03473 196164000520 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196164000521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164000522 active site 196164000523 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196164000524 active site 196164000525 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 196164000526 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 196164000527 Walker A/P-loop; other site 196164000528 ATP binding site [chemical binding]; other site 196164000529 Q-loop/lid; other site 196164000530 ABC transporter signature motif; other site 196164000531 Walker B; other site 196164000532 D-loop; other site 196164000533 H-loop/switch region; other site 196164000534 ABC-2 type transporter; Region: ABC2_membrane; cl11417 196164000535 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 196164000536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196164000537 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 196164000538 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 196164000539 NAD(P) binding site [chemical binding]; other site 196164000540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196164000541 catalytic loop [active] 196164000542 iron binding site [ion binding]; other site 196164000543 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 196164000544 putative active site [active] 196164000545 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK05597 196164000546 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 196164000547 ATP binding site [chemical binding]; other site 196164000548 substrate interface [chemical binding]; other site 196164000549 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196164000550 active site residue [active] 196164000551 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 196164000552 MoaE homodimer interface [polypeptide binding]; other site 196164000553 MoaD interaction [polypeptide binding]; other site 196164000554 active site residues [active] 196164000555 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 196164000556 MPT binding site; other site 196164000557 trimer interface [polypeptide binding]; other site 196164000558 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 196164000559 trimer interface [polypeptide binding]; other site 196164000560 dimer interface [polypeptide binding]; other site 196164000561 putative active site [active] 196164000562 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196164000563 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196164000564 dimer interface [polypeptide binding]; other site 196164000565 putative functional site; other site 196164000566 putative MPT binding site; other site 196164000567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164000568 dimer interface [polypeptide binding]; other site 196164000569 conserved gate region; other site 196164000570 putative PBP binding loops; other site 196164000571 ABC-ATPase subunit interface; other site 196164000572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164000573 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 196164000574 MoaE interaction surface [polypeptide binding]; other site 196164000575 MoeB interaction surface [polypeptide binding]; other site 196164000576 thiocarboxylated glycine; other site 196164000577 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 196164000578 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 196164000579 Walker A/P-loop; other site 196164000580 ATP binding site [chemical binding]; other site 196164000581 Q-loop/lid; other site 196164000582 ABC transporter signature motif; other site 196164000583 Walker B; other site 196164000584 D-loop; other site 196164000585 H-loop/switch region; other site 196164000586 Membrane protein of unknown function; Region: DUF360; cl00850 196164000587 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 196164000588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164000589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164000590 homodimer interface [polypeptide binding]; other site 196164000591 catalytic residue [active] 196164000592 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 196164000593 transmembrane helices; other site 196164000594 prephenate dehydrogenase; Validated; Region: PRK06545 196164000595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000596 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 196164000597 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 196164000598 nucleoside/Zn binding site; other site 196164000599 dimer interface [polypeptide binding]; other site 196164000600 catalytic motif [active] 196164000601 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 196164000602 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 196164000603 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 196164000604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164000605 active site 196164000606 HIGH motif; other site 196164000607 nucleotide binding site [chemical binding]; other site 196164000608 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164000609 active site 196164000610 KMSKS motif; other site 196164000611 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196164000612 Domain of unknown function DUF21; Region: DUF21; pfam01595 196164000613 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196164000614 Transporter associated domain; Region: CorC_HlyC; cl08393 196164000615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196164000616 Coenzyme A binding pocket [chemical binding]; other site 196164000617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000618 NAD(P) binding site [chemical binding]; other site 196164000619 active site 196164000620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164000621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164000622 homodimer interface [polypeptide binding]; other site 196164000623 catalytic residue [active] 196164000624 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 196164000625 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 196164000626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164000627 Walker A motif; other site 196164000628 ATP binding site [chemical binding]; other site 196164000629 Walker B motif; other site 196164000630 arginine finger; other site 196164000631 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 196164000632 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 196164000633 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 196164000634 recombination protein RecR; Reviewed; Region: recR; PRK00076 196164000635 RecR protein; Region: RecR; pfam02132 196164000636 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 196164000637 putative active site [active] 196164000638 putative metal-binding site [ion binding]; other site 196164000639 tetramer interface [polypeptide binding]; other site 196164000640 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 196164000641 catalytic triad [active] 196164000642 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 196164000643 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 196164000644 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 196164000645 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196164000646 active site 196164000647 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 196164000648 2-isopropylmalate synthase; Validated; Region: PRK03739 196164000649 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 196164000650 active site 196164000651 catalytic residues [active] 196164000652 metal binding site [ion binding]; metal-binding site 196164000653 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 196164000654 aspartate kinase; Reviewed; Region: PRK06635 196164000655 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 196164000656 putative nucleotide binding site [chemical binding]; other site 196164000657 putative catalytic residues [active] 196164000658 putative Mg ion binding site [ion binding]; other site 196164000659 putative aspartate binding site [chemical binding]; other site 196164000660 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 196164000661 putative allosteric regulatory site; other site 196164000662 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 196164000663 putative allosteric regulatory residue; other site 196164000664 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 196164000665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000666 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 196164000667 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 196164000668 Cation efflux family; Region: Cation_efflux; cl00316 196164000669 RNA polymerase sigma factor; Provisional; Region: PRK12535 196164000670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164000671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164000672 DNA binding residues [nucleotide binding] 196164000673 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 196164000674 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 196164000675 tetramer interface [polypeptide binding]; other site 196164000676 heme binding pocket [chemical binding]; other site 196164000677 NADPH binding site [chemical binding]; other site 196164000678 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 196164000679 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 196164000680 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164000681 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 196164000682 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 196164000683 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 196164000684 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 196164000685 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164000686 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 196164000687 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 196164000688 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 196164000689 Predicted membrane protein [Function unknown]; Region: COG1511 196164000690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196164000691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164000692 active site 196164000693 phosphorylation site [posttranslational modification] 196164000694 intermolecular recognition site; other site 196164000695 dimerization interface [polypeptide binding]; other site 196164000696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196164000697 DNA binding site [nucleotide binding] 196164000698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196164000699 dimerization interface [polypeptide binding]; other site 196164000700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196164000701 dimer interface [polypeptide binding]; other site 196164000702 phosphorylation site [posttranslational modification] 196164000703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164000704 ATP binding site [chemical binding]; other site 196164000705 Mg2+ binding site [ion binding]; other site 196164000706 G-X-G motif; other site 196164000707 Glycerate kinase family; Region: Gly_kinase; cl00841 196164000708 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 196164000709 transmembrane helices; other site 196164000710 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164000711 MULE transposase domain; Region: MULE; pfam10551 196164000712 MULE transposase domain; Region: MULE; pfam10551 196164000713 Helix-turn-helix domains; Region: HTH; cl00088 196164000714 putative transposase OrfB; Reviewed; Region: PHA02517 196164000715 Integrase core domain; Region: rve; cl01316 196164000716 Helix-turn-helix domains; Region: HTH; cl00088 196164000717 putative transposase OrfB; Reviewed; Region: PHA02517 196164000718 Integrase core domain; Region: rve; cl01316 196164000719 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164000720 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164000721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164000722 non-specific DNA binding site [nucleotide binding]; other site 196164000723 salt bridge; other site 196164000724 sequence-specific DNA binding site [nucleotide binding]; other site 196164000725 Nuclease-related domain; Region: NERD; pfam08378 196164000726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 196164000727 Transposase; Region: DDE_Tnp_ISL3; pfam01610 196164000728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 196164000729 Transposase; Region: DDE_Tnp_ISL3; pfam01610 196164000730 HsdM N-terminal domain; Region: HsdM_N; pfam12161 196164000731 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 196164000732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164000733 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196164000734 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 196164000735 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 196164000736 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 196164000737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000739 Protein of unknown function DUF45; Region: DUF45; cl00636 196164000740 Integrase core domain; Region: rve; cl01316 196164000741 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 196164000742 Helix-turn-helix domains; Region: HTH; cl00088 196164000743 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 196164000744 HIT family signature motif; other site 196164000745 catalytic residue [active] 196164000746 TIR domain; Region: TIR; cl02060 196164000747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196164000748 Int/Topo IB signature motif; other site 196164000749 active site 196164000750 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 196164000751 Int/Topo IB signature motif; other site 196164000752 active site 196164000753 catalytic residues [active] 196164000754 DNA binding site [nucleotide binding] 196164000755 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 196164000756 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 196164000757 putative active site [active] 196164000758 putative metal binding site [ion binding]; other site 196164000759 GatB domain; Region: GatB_Yqey; cl11497 196164000760 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 196164000761 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 196164000762 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 196164000763 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 196164000764 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 196164000765 Transglycosylase; Region: Transgly; cl07896 196164000766 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 196164000767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164000768 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196164000769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164000770 active site 196164000771 phosphorylation site [posttranslational modification] 196164000772 intermolecular recognition site; other site 196164000773 dimerization interface [polypeptide binding]; other site 196164000774 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196164000775 DNA binding site [nucleotide binding] 196164000776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196164000777 dimerization interface [polypeptide binding]; other site 196164000778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196164000779 dimer interface [polypeptide binding]; other site 196164000780 phosphorylation site [posttranslational modification] 196164000781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164000782 ATP binding site [chemical binding]; other site 196164000783 Mg2+ binding site [ion binding]; other site 196164000784 G-X-G motif; other site 196164000785 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 196164000786 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164000787 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164000788 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 196164000789 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 196164000790 Transcription factor WhiB; Region: Whib; pfam02467 196164000791 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 196164000792 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 196164000793 homotrimer interaction site [polypeptide binding]; other site 196164000794 putative active site [active] 196164000795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164000796 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 196164000797 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196164000798 ligand binding site [chemical binding]; other site 196164000799 flexible hinge region; other site 196164000800 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 196164000801 putative switch regulator; other site 196164000802 non-specific DNA interactions [nucleotide binding]; other site 196164000803 DNA binding site [nucleotide binding] 196164000804 sequence specific DNA binding site [nucleotide binding]; other site 196164000805 putative cAMP binding site [chemical binding]; other site 196164000806 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 196164000807 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196164000808 minor groove reading motif; other site 196164000809 helix-hairpin-helix signature motif; other site 196164000810 substrate binding pocket [chemical binding]; other site 196164000811 active site 196164000812 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 196164000813 catalytic residues [active] 196164000814 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 196164000815 putative active site [active] 196164000816 putative CoA binding site [chemical binding]; other site 196164000817 nudix motif; other site 196164000818 metal binding site [ion binding]; metal-binding site 196164000819 Colicin V production protein; Region: Colicin_V; cl00567 196164000820 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164000821 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196164000823 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 196164000824 Transposase domain (DUF772); Region: DUF772; cl12084 196164000825 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164000826 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 196164000827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164000828 motif II; other site 196164000829 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 196164000830 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 196164000831 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 196164000832 ATP binding site [chemical binding]; other site 196164000833 Walker A motif; other site 196164000834 hexamer interface [polypeptide binding]; other site 196164000835 Walker B motif; other site 196164000836 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 196164000837 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 196164000838 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 196164000839 Helix-turn-helix domains; Region: HTH; cl00088 196164000840 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 196164000841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164000842 ATP binding site [chemical binding]; other site 196164000843 putative Mg++ binding site [ion binding]; other site 196164000844 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 196164000845 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 196164000846 DNA-binding site [nucleotide binding]; DNA binding site 196164000847 RNA-binding motif; other site 196164000848 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 196164000849 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 196164000850 active site 196164000851 interdomain interaction site; other site 196164000852 putative metal-binding site [ion binding]; other site 196164000853 nucleotide binding site [chemical binding]; other site 196164000854 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 196164000855 domain I; other site 196164000856 phosphate binding site [ion binding]; other site 196164000857 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 196164000858 domain II; other site 196164000859 domain III; other site 196164000860 nucleotide binding site [chemical binding]; other site 196164000861 DNA binding groove [nucleotide binding] 196164000862 catalytic site [active] 196164000863 domain IV; other site 196164000864 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196164000865 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196164000866 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196164000867 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 196164000868 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 196164000869 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 196164000870 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 196164000871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196164000872 dimerization interface [polypeptide binding]; other site 196164000873 cyclase homology domain; Region: CHD; cd07302 196164000874 nucleotidyl binding site; other site 196164000875 metal binding site [ion binding]; metal-binding site 196164000876 dimer interface [polypeptide binding]; other site 196164000877 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 196164000878 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 196164000879 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196164000880 Helix-turn-helix domains; Region: HTH; cl00088 196164000881 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 196164000882 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196164000883 active site residue [active] 196164000884 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 196164000885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164000886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 196164000887 active site residue [active] 196164000888 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 196164000889 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 196164000890 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 196164000891 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164000892 substrate binding site [chemical binding]; other site 196164000893 oxyanion hole (OAH) forming residues; other site 196164000894 trimer interface [polypeptide binding]; other site 196164000895 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 196164000896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164000897 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 196164000898 acyl-coenzyme A oxidase; Region: PLN02526 196164000899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196164000900 active site 196164000901 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 196164000902 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196164000903 dimer interface [polypeptide binding]; other site 196164000904 active site 196164000905 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 196164000906 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164000907 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164000908 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 196164000909 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 196164000910 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 196164000911 active site 196164000912 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 196164000913 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 196164000914 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 196164000915 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 196164000916 NAD binding site [chemical binding]; other site 196164000917 catalytic Zn binding site [ion binding]; other site 196164000918 substrate binding site [chemical binding]; other site 196164000919 structural Zn binding site [ion binding]; other site 196164000920 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164000921 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 196164000923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 196164000924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000925 NAD(P) binding site [chemical binding]; other site 196164000926 active site 196164000927 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 196164000928 Ligand binding site; other site 196164000929 Putative Catalytic site; other site 196164000930 DXD motif; other site 196164000931 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196164000932 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 196164000933 Probable Catalytic site; other site 196164000934 metal-binding site 196164000935 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 196164000936 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 196164000937 putative active site [active] 196164000938 putative metal binding site [ion binding]; other site 196164000939 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 196164000940 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 196164000941 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 196164000942 putative NAD(P) binding site [chemical binding]; other site 196164000943 putative substrate binding site [chemical binding]; other site 196164000944 catalytic Zn binding site [ion binding]; other site 196164000945 structural Zn binding site [ion binding]; other site 196164000946 dimer interface [polypeptide binding]; other site 196164000947 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 196164000948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000949 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196164000950 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 196164000951 active site residue [active] 196164000952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000953 Q-loop/lid; other site 196164000954 ABC transporter signature motif; other site 196164000955 Integrase core domain; Region: rve; cl01316 196164000956 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 196164000957 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 196164000958 substrate binding site; other site 196164000959 tetramer interface; other site 196164000960 Cupin domain; Region: Cupin_2; cl09118 196164000961 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 196164000962 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 196164000963 NADP binding site [chemical binding]; other site 196164000964 active site 196164000965 putative substrate binding site [chemical binding]; other site 196164000966 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 196164000967 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 196164000968 NAD binding site [chemical binding]; other site 196164000969 substrate binding site [chemical binding]; other site 196164000970 homodimer interface [polypeptide binding]; other site 196164000971 active site 196164000972 LabA_like proteins; Region: LabA_like; cd06167 196164000973 putative metal binding site [ion binding]; other site 196164000974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000975 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 196164000976 Q-loop/lid; other site 196164000977 ABC transporter signature motif; other site 196164000978 Walker B; other site 196164000979 D-loop; other site 196164000980 H-loop/switch region; other site 196164000981 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535 196164000982 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 196164000983 Zn binding site [ion binding]; other site 196164000984 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 196164000985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164000986 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 196164000987 Predicted esterase [General function prediction only]; Region: COG0627 196164000988 Chain length determinant protein; Region: Wzz; cl01623 196164000989 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 196164000990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164000991 Low molecular weight phosphatase family; Region: LMWPc; cd00115 196164000992 active site 196164000993 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 196164000994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164000995 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 196164000996 NAD(P) binding site [chemical binding]; other site 196164000997 homodimer interface [polypeptide binding]; other site 196164000998 substrate binding site [chemical binding]; other site 196164000999 active site 196164001000 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 196164001001 Mg++ binding site [ion binding]; other site 196164001002 putative catalytic motif [active] 196164001003 putative substrate binding site [chemical binding]; other site 196164001004 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 196164001005 putative NAD(P) binding site [chemical binding]; other site 196164001006 active site 196164001007 putative substrate binding site [chemical binding]; other site 196164001008 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 196164001009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164001010 putative ADP-binding pocket [chemical binding]; other site 196164001011 HTH-like domain; Region: HTH_21; pfam13276 196164001012 Integrase core domain; Region: rve; cl01316 196164001013 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 196164001014 Integrase core domain; Region: rve; cl01316 196164001015 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 196164001016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164001017 Walker A motif; other site 196164001018 ATP binding site [chemical binding]; other site 196164001019 Walker B motif; other site 196164001020 putative transposase OrfB; Reviewed; Region: PHA02517 196164001021 Integrase core domain; Region: rve; cl01316 196164001022 Helix-turn-helix domains; Region: HTH; cl00088 196164001023 putative transposase OrfB; Reviewed; Region: PHA02517 196164001024 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164001025 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164001026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164001027 non-specific DNA binding site [nucleotide binding]; other site 196164001028 salt bridge; other site 196164001029 sequence-specific DNA binding site [nucleotide binding]; other site 196164001030 Integrase core domain; Region: rve; cl01316 196164001031 Helix-turn-helix domains; Region: HTH; cl00088 196164001032 putative transposase OrfB; Reviewed; Region: PHA02517 196164001033 Integrase core domain; Region: rve; cl01316 196164001034 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164001035 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164001036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164001037 non-specific DNA binding site [nucleotide binding]; other site 196164001038 salt bridge; other site 196164001039 sequence-specific DNA binding site [nucleotide binding]; other site 196164001040 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 196164001041 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 196164001042 active site 196164001043 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 196164001044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001045 NAD(P) binding site [chemical binding]; other site 196164001046 active site 196164001047 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 196164001048 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 196164001049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001050 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 196164001051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001053 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196164001054 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 196164001055 putative deacylase active site [active] 196164001056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 196164001057 Helix-turn-helix domains; Region: HTH; cl00088 196164001058 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 196164001059 Domain of unknown function (DUF955); Region: DUF955; cl01076 196164001060 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 196164001061 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 196164001062 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 196164001063 putative Iron-sulfur protein interface [polypeptide binding]; other site 196164001064 proximal heme binding site [chemical binding]; other site 196164001065 distal heme binding site [chemical binding]; other site 196164001066 putative dimer interface [polypeptide binding]; other site 196164001067 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 196164001068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001069 domain; Region: Succ_DH_flav_C; pfam02910 196164001070 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 196164001071 Transposase domain (DUF772); Region: DUF772; cl12084 196164001072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164001073 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 196164001074 Predicted membrane protein [Function unknown]; Region: COG2733 196164001075 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 196164001076 Helix-turn-helix domains; Region: HTH; cl00088 196164001077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164001079 putative substrate translocation pore; other site 196164001080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001081 Abi-like protein; Region: Abi_2; cl01988 196164001082 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 196164001083 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 196164001084 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 196164001085 putative active site [active] 196164001086 putative substrate binding site [chemical binding]; other site 196164001087 putative cosubstrate binding site; other site 196164001088 catalytic site [active] 196164001089 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 196164001090 intersubunit interface [polypeptide binding]; other site 196164001091 active site 196164001092 catalytic residue [active] 196164001093 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 196164001094 TPP-binding site [chemical binding]; other site 196164001095 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 196164001096 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 196164001097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001098 putative substrate translocation pore; other site 196164001099 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 196164001100 putative homotetramer interface [polypeptide binding]; other site 196164001101 putative homodimer interface [polypeptide binding]; other site 196164001102 putative allosteric switch controlling residues; other site 196164001103 putative metal binding site [ion binding]; other site 196164001104 putative homodimer-homodimer interface [polypeptide binding]; other site 196164001105 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196164001106 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196164001107 metal-binding site [ion binding] 196164001108 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164001109 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 196164001110 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 196164001111 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 196164001112 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164001113 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164001114 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 196164001115 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 196164001116 Protein of unknown function (DUF419); Region: DUF419; cl15265 196164001117 Abi-like protein; Region: Abi_2; cl01988 196164001118 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 196164001119 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164001120 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 196164001121 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 196164001122 putative ADP-binding pocket [chemical binding]; other site 196164001123 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164001124 catalytic core [active] 196164001125 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164001126 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 196164001127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196164001128 dimer interface [polypeptide binding]; other site 196164001129 phosphorylation site [posttranslational modification] 196164001130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164001131 ATP binding site [chemical binding]; other site 196164001132 Mg2+ binding site [ion binding]; other site 196164001133 G-X-G motif; other site 196164001134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196164001135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164001136 active site 196164001137 phosphorylation site [posttranslational modification] 196164001138 intermolecular recognition site; other site 196164001139 dimerization interface [polypeptide binding]; other site 196164001140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196164001141 DNA binding site [nucleotide binding] 196164001142 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196164001143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 196164001144 FtsX-like permease family; Region: FtsX; cl15850 196164001145 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 196164001146 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 196164001147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001148 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164001149 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 196164001150 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164001151 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 196164001152 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 196164001153 tRNA; other site 196164001154 putative tRNA binding site [nucleotide binding]; other site 196164001155 putative NADP binding site [chemical binding]; other site 196164001156 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 196164001157 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 196164001158 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 196164001159 domain interfaces; other site 196164001160 active site 196164001161 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 196164001162 proposed catalytic triad [active] 196164001163 conserved cys residue [active] 196164001164 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 196164001165 Helix-turn-helix domains; Region: HTH; cl00088 196164001166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164001167 dimerization interface [polypeptide binding]; other site 196164001168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001169 metabolite-proton symporter; Region: 2A0106; TIGR00883 196164001170 putative substrate translocation pore; other site 196164001171 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 196164001172 AP (apurinic/apyrimidinic) site pocket; other site 196164001173 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 196164001174 DNA interaction; other site 196164001175 Metal-binding active site; metal-binding site 196164001176 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 196164001177 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 196164001178 active site 196164001179 Fe binding site [ion binding]; other site 196164001180 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 196164001181 active site 196164001182 trimer interface [polypeptide binding]; other site 196164001183 dimer interface [polypeptide binding]; other site 196164001184 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027 196164001185 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196164001186 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196164001187 shikimate binding site; other site 196164001188 NAD(P) binding site [chemical binding]; other site 196164001189 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164001190 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 196164001191 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 196164001192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164001193 Walker A/P-loop; other site 196164001194 ATP binding site [chemical binding]; other site 196164001195 Q-loop/lid; other site 196164001196 ABC transporter signature motif; other site 196164001197 Walker B; other site 196164001198 D-loop; other site 196164001199 H-loop/switch region; other site 196164001200 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 196164001201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164001202 conserved gate region; other site 196164001203 dimer interface [polypeptide binding]; other site 196164001204 putative PBP binding loops; other site 196164001205 ABC-ATPase subunit interface; other site 196164001206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196164001207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196164001208 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 196164001209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164001210 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 196164001211 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 196164001212 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 196164001213 active site 196164001214 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 196164001215 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 196164001216 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 196164001217 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 196164001218 dimer interface [polypeptide binding]; other site 196164001219 active site 196164001220 Schiff base residues; other site 196164001221 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 196164001222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 196164001223 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164001224 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164001225 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 196164001226 substrate binding site [chemical binding]; other site 196164001227 active site 196164001228 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 196164001229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001230 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 196164001231 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196164001232 inhibitor-cofactor binding pocket; inhibition site 196164001233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164001234 catalytic residue [active] 196164001235 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164001236 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 196164001237 catalytic core [active] 196164001238 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 196164001239 catalytic residues [active] 196164001240 LysE type translocator; Region: LysE; cl00565 196164001241 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 196164001242 ResB-like family; Region: ResB; pfam05140 196164001243 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 196164001244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164001245 dimerization interface [polypeptide binding]; other site 196164001246 putative DNA binding site [nucleotide binding]; other site 196164001247 putative Zn2+ binding site [ion binding]; other site 196164001248 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 196164001249 UbiA prenyltransferase family; Region: UbiA; cl00337 196164001250 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164001251 Phosphate transporter family; Region: PHO4; cl00396 196164001252 naphthoate synthase; Validated; Region: PRK08321 196164001253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164001254 substrate binding site [chemical binding]; other site 196164001255 oxyanion hole (OAH) forming residues; other site 196164001256 trimer interface [polypeptide binding]; other site 196164001257 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 196164001258 aromatic arch; other site 196164001259 DCoH dimer interaction site [polypeptide binding]; other site 196164001260 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 196164001261 DCoH tetramer interaction site [polypeptide binding]; other site 196164001262 substrate binding site [chemical binding]; other site 196164001263 O-succinylbenzoate synthase; Provisional; Region: PRK02901 196164001264 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 196164001265 active site 196164001266 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 196164001267 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 196164001268 dimer interface [polypeptide binding]; other site 196164001269 tetramer interface [polypeptide binding]; other site 196164001270 PYR/PP interface [polypeptide binding]; other site 196164001271 TPP binding site [chemical binding]; other site 196164001272 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 196164001273 TPP-binding site; other site 196164001274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164001275 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 196164001276 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 196164001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164001278 S-adenosylmethionine binding site [chemical binding]; other site 196164001279 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 196164001280 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 196164001281 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196164001282 substrate binding pocket [chemical binding]; other site 196164001283 chain length determination region; other site 196164001284 substrate-Mg2+ binding site; other site 196164001285 catalytic residues [active] 196164001286 aspartate-rich region 1; other site 196164001287 active site lid residues [active] 196164001288 aspartate-rich region 2; other site 196164001289 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 196164001290 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 196164001291 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 196164001292 putative homodimer interface [polypeptide binding]; other site 196164001293 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 196164001294 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 196164001295 23S rRNA interface [nucleotide binding]; other site 196164001296 L7/L12 interface [polypeptide binding]; other site 196164001297 putative thiostrepton binding site; other site 196164001298 L25 interface [polypeptide binding]; other site 196164001299 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 196164001300 mRNA/rRNA interface [nucleotide binding]; other site 196164001301 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164001302 Q-loop/lid; other site 196164001303 ABC transporter signature motif; other site 196164001304 Walker B; other site 196164001305 D-loop; other site 196164001306 H-loop/switch region; other site 196164001307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164001308 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 196164001309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001310 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 196164001311 23S rRNA interface [nucleotide binding]; other site 196164001312 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 196164001313 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 196164001314 L11 interface [polypeptide binding]; other site 196164001315 putative EF-Tu interaction site [polypeptide binding]; other site 196164001316 putative EF-G interaction site [polypeptide binding]; other site 196164001317 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 196164001318 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 196164001319 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 196164001320 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 196164001321 RPB1 interaction site [polypeptide binding]; other site 196164001322 RPB10 interaction site [polypeptide binding]; other site 196164001323 RPB11 interaction site [polypeptide binding]; other site 196164001324 RPB3 interaction site [polypeptide binding]; other site 196164001325 RPB12 interaction site [polypeptide binding]; other site 196164001326 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 196164001327 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 196164001328 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 196164001329 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 196164001330 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 196164001331 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 196164001332 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 196164001333 G-loop; other site 196164001334 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 196164001335 DNA binding site [nucleotide binding] 196164001336 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 196164001337 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164001338 MULE transposase domain; Region: MULE; pfam10551 196164001339 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 196164001340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164001341 Walker A motif; other site 196164001342 ATP binding site [chemical binding]; other site 196164001343 Walker B motif; other site 196164001344 Integrase core domain; Region: rve; cl01316 196164001345 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164001346 Helix-turn-helix domains; Region: HTH; cl00088 196164001347 Helix-turn-helix domains; Region: HTH; cl00088 196164001348 putative transposase OrfB; Reviewed; Region: PHA02517 196164001349 Integrase core domain; Region: rve; cl01316 196164001350 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164001351 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164001352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164001353 non-specific DNA binding site [nucleotide binding]; other site 196164001354 salt bridge; other site 196164001355 sequence-specific DNA binding site [nucleotide binding]; other site 196164001356 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164001357 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164001358 MULE transposase domain; Region: MULE; pfam10551 196164001359 Helix-turn-helix domains; Region: HTH; cl00088 196164001360 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196164001361 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 196164001362 S17 interaction site [polypeptide binding]; other site 196164001363 S8 interaction site; other site 196164001364 16S rRNA interaction site [nucleotide binding]; other site 196164001365 streptomycin interaction site [chemical binding]; other site 196164001366 23S rRNA interaction site [nucleotide binding]; other site 196164001367 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 196164001368 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 196164001369 elongation factor G; Reviewed; Region: PRK00007 196164001370 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 196164001371 G1 box; other site 196164001372 putative GEF interaction site [polypeptide binding]; other site 196164001373 GTP/Mg2+ binding site [chemical binding]; other site 196164001374 Switch I region; other site 196164001375 G2 box; other site 196164001376 G3 box; other site 196164001377 Switch II region; other site 196164001378 G4 box; other site 196164001379 G5 box; other site 196164001380 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 196164001381 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 196164001382 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 196164001383 elongation factor Tu; Reviewed; Region: PRK00049 196164001384 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 196164001385 G1 box; other site 196164001386 GEF interaction site [polypeptide binding]; other site 196164001387 GTP/Mg2+ binding site [chemical binding]; other site 196164001388 Switch I region; other site 196164001389 G2 box; other site 196164001390 G3 box; other site 196164001391 Switch II region; other site 196164001392 G4 box; other site 196164001393 G5 box; other site 196164001394 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 196164001395 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 196164001396 Antibiotic Binding Site [chemical binding]; other site 196164001397 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 196164001398 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 196164001399 conserved cys residue [active] 196164001400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196164001401 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 196164001402 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 196164001403 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164001404 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 196164001405 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 196164001406 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 196164001407 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 196164001408 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 196164001409 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 196164001410 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 196164001411 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 196164001412 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 196164001413 putative translocon binding site; other site 196164001414 protein-rRNA interface [nucleotide binding]; other site 196164001415 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 196164001416 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 196164001417 G-X-X-G motif; other site 196164001418 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 196164001419 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 196164001420 23S rRNA interface [nucleotide binding]; other site 196164001421 5S rRNA interface [nucleotide binding]; other site 196164001422 putative antibiotic binding site [chemical binding]; other site 196164001423 L25 interface [polypeptide binding]; other site 196164001424 L27 interface [polypeptide binding]; other site 196164001425 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 196164001426 putative translocon interaction site; other site 196164001427 signal recognition particle (SRP54) interaction site; other site 196164001428 L23 interface [polypeptide binding]; other site 196164001429 trigger factor interaction site; other site 196164001430 23S rRNA interface [nucleotide binding]; other site 196164001431 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 196164001432 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 196164001433 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 196164001434 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 196164001435 KOW motif; Region: KOW; cl00354 196164001436 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 196164001437 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 196164001438 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 196164001439 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 196164001440 active site 196164001441 catalytic triad [active] 196164001442 oxyanion hole [active] 196164001443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196164001444 active site 196164001445 catalytic tetrad [active] 196164001446 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 196164001447 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 196164001448 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 196164001449 putative molybdopterin cofactor binding site [chemical binding]; other site 196164001450 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 196164001451 putative molybdopterin cofactor binding site; other site 196164001452 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 196164001453 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 196164001454 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 196164001455 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196164001456 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 196164001457 Walker A/P-loop; other site 196164001458 ATP binding site [chemical binding]; other site 196164001459 Q-loop/lid; other site 196164001460 ABC transporter signature motif; other site 196164001461 Walker B; other site 196164001462 D-loop; other site 196164001463 H-loop/switch region; other site 196164001464 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 196164001465 Walker A/P-loop; other site 196164001466 ATP binding site [chemical binding]; other site 196164001467 Q-loop/lid; other site 196164001468 ABC transporter signature motif; other site 196164001469 Walker B; other site 196164001470 D-loop; other site 196164001471 H-loop/switch region; other site 196164001472 Cobalt transport protein; Region: CbiQ; cl00463 196164001473 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 196164001474 Predicted acetyltransferase [General function prediction only]; Region: COG3981 196164001475 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164001476 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 196164001477 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 196164001478 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 196164001479 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 196164001480 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 196164001481 5S rRNA interface [nucleotide binding]; other site 196164001482 L27 interface [polypeptide binding]; other site 196164001483 23S rRNA interface [nucleotide binding]; other site 196164001484 L5 interface [polypeptide binding]; other site 196164001485 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 196164001486 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 196164001487 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 196164001488 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 196164001489 23S rRNA binding site [nucleotide binding]; other site 196164001490 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 196164001491 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196164001492 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 196164001493 NAD binding site [chemical binding]; other site 196164001494 catalytic residues [active] 196164001495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 196164001496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 196164001497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001498 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196164001499 catalytic loop [active] 196164001500 iron binding site [ion binding]; other site 196164001501 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 196164001502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001503 NAD(P) binding site [chemical binding]; other site 196164001504 active site 196164001505 hypothetical protein; Provisional; Region: PRK08296 196164001506 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 196164001507 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 196164001508 Cytochrome P450; Region: p450; cl12078 196164001509 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196164001510 Helix-turn-helix domains; Region: HTH; cl00088 196164001511 Bacterial transcriptional regulator; Region: IclR; pfam01614 196164001512 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 196164001513 SecY translocase; Region: SecY; pfam00344 196164001514 adenylate kinase; Reviewed; Region: adk; PRK00279 196164001515 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 196164001516 AMP-binding site [chemical binding]; other site 196164001517 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 196164001518 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 196164001519 active site 196164001520 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 196164001521 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 196164001522 rRNA binding site [nucleotide binding]; other site 196164001523 predicted 30S ribosome binding site; other site 196164001524 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 196164001525 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 196164001526 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 196164001527 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 196164001528 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 196164001529 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196164001530 RNA binding surface [nucleotide binding]; other site 196164001531 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 196164001532 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 196164001533 alphaNTD - beta interaction site [polypeptide binding]; other site 196164001534 alphaNTD homodimer interface [polypeptide binding]; other site 196164001535 alphaNTD - beta' interaction site [polypeptide binding]; other site 196164001536 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 196164001537 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 196164001538 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 196164001539 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 196164001540 dimerization interface 3.5A [polypeptide binding]; other site 196164001541 active site 196164001542 Protein of unknown function (DUF690); Region: DUF690; cl04939 196164001543 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 196164001544 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 196164001545 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 196164001546 active site 196164001547 catalytic residues [active] 196164001548 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 196164001549 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 196164001550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164001551 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 196164001552 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164001553 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 196164001554 Proteins of 100 residues with WXG; Region: WXG100; cl02005 196164001555 Proteins of 100 residues with WXG; Region: WXG100; cl02005 196164001556 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 196164001557 putative dimer interface [polypeptide binding]; other site 196164001558 putative [2Fe-2S] cluster binding site [ion binding]; other site 196164001559 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 196164001560 23S rRNA interface [nucleotide binding]; other site 196164001561 L3 interface [polypeptide binding]; other site 196164001562 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 196164001563 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 196164001564 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 196164001565 active site 196164001566 substrate binding site [chemical binding]; other site 196164001567 metal binding site [ion binding]; metal-binding site 196164001568 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 196164001569 alanine racemase; Reviewed; Region: alr; PRK00053 196164001570 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 196164001571 active site 196164001572 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196164001573 dimer interface [polypeptide binding]; other site 196164001574 substrate binding site [chemical binding]; other site 196164001575 catalytic residues [active] 196164001576 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 196164001577 Predicted permease [General function prediction only]; Region: COG2985 196164001578 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 196164001579 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 196164001580 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 196164001581 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 196164001582 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 196164001583 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 196164001584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196164001585 Coenzyme A binding pocket [chemical binding]; other site 196164001586 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164001587 UGMP family protein; Validated; Region: PRK09604 196164001588 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 196164001589 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 196164001590 putative substrate binding site [chemical binding]; other site 196164001591 putative ATP binding site [chemical binding]; other site 196164001592 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 196164001593 oligomerisation interface [polypeptide binding]; other site 196164001594 mobile loop; other site 196164001595 roof hairpin; other site 196164001596 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 196164001597 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 196164001598 ring oligomerisation interface [polypeptide binding]; other site 196164001599 ATP/Mg binding site [chemical binding]; other site 196164001600 stacking interactions; other site 196164001601 hinge regions; other site 196164001602 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196164001603 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 196164001604 NAD(P) binding site [chemical binding]; other site 196164001605 catalytic residues [active] 196164001606 Transcription factor WhiB; Region: Whib; pfam02467 196164001607 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 196164001608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164001609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164001610 DNA binding residues [nucleotide binding] 196164001611 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 196164001612 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 196164001613 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 196164001614 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 196164001615 active site 196164001616 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 196164001617 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 196164001618 active site 196164001619 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 196164001620 GntP family permease; Region: GntP_permease; pfam02447 196164001621 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 196164001622 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196164001623 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 196164001624 putative active site [active] 196164001625 GMP synthase; Reviewed; Region: guaA; PRK00074 196164001626 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 196164001627 AMP/PPi binding site [chemical binding]; other site 196164001628 candidate oxyanion hole; other site 196164001629 catalytic triad [active] 196164001630 potential glutamine specificity residues [chemical binding]; other site 196164001631 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 196164001632 ATP Binding subdomain [chemical binding]; other site 196164001633 Ligand Binding sites [chemical binding]; other site 196164001634 Dimerization subdomain; other site 196164001635 PspC domain; Region: PspC; cl00864 196164001636 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 196164001637 PspC domain; Region: PspC; cl00864 196164001638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196164001639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164001640 ATP binding site [chemical binding]; other site 196164001641 Mg2+ binding site [ion binding]; other site 196164001642 G-X-G motif; other site 196164001643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164001644 active site 196164001645 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196164001646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164001647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164001648 active site 196164001649 phosphorylation site [posttranslational modification] 196164001650 intermolecular recognition site; other site 196164001651 dimerization interface [polypeptide binding]; other site 196164001652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164001653 dimerization interface [polypeptide binding]; other site 196164001654 DNA binding residues [nucleotide binding] 196164001655 DNA Polymerase Y-family; Region: PolY_like; cd03468 196164001656 active site 196164001657 DNA binding site [nucleotide binding] 196164001658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164001659 dimer interface [polypeptide binding]; other site 196164001660 conserved gate region; other site 196164001661 putative PBP binding loops; other site 196164001662 ABC-ATPase subunit interface; other site 196164001663 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 196164001664 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 196164001665 Walker A/P-loop; other site 196164001666 ATP binding site [chemical binding]; other site 196164001667 Q-loop/lid; other site 196164001668 ABC transporter signature motif; other site 196164001669 Walker B; other site 196164001670 D-loop; other site 196164001671 H-loop/switch region; other site 196164001672 NIL domain; Region: NIL; cl09633 196164001673 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 196164001674 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 196164001675 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 196164001676 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 196164001677 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 196164001678 generic binding surface II; other site 196164001679 generic binding surface I; other site 196164001680 Helix-turn-helix domains; Region: HTH; cl00088 196164001681 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 196164001682 Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532 196164001683 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 196164001684 alpha subunit interface [polypeptide binding]; other site 196164001685 active site 196164001686 substrate binding site [chemical binding]; other site 196164001687 Fe binding site [ion binding]; other site 196164001688 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 196164001689 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 196164001690 FMN-binding pocket [chemical binding]; other site 196164001691 flavin binding motif; other site 196164001692 phosphate binding motif [ion binding]; other site 196164001693 beta-alpha-beta structure motif; other site 196164001694 NAD binding pocket [chemical binding]; other site 196164001695 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196164001696 catalytic loop [active] 196164001697 iron binding site [ion binding]; other site 196164001698 benzoate transport; Region: 2A0115; TIGR00895 196164001699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001700 putative substrate translocation pore; other site 196164001701 UbiA prenyltransferase family; Region: UbiA; cl00337 196164001702 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 196164001703 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 196164001704 phytoene desaturase; Region: crtI_fam; TIGR02734 196164001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001706 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 196164001707 active site lid residues [active] 196164001708 substrate binding pocket [chemical binding]; other site 196164001709 catalytic residues [active] 196164001710 substrate-Mg2+ binding site; other site 196164001711 aspartate-rich region 1; other site 196164001712 aspartate-rich region 2; other site 196164001713 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 196164001714 Protein export membrane protein; Region: SecD_SecF; cl14618 196164001715 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 196164001716 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196164001717 substrate binding pocket [chemical binding]; other site 196164001718 chain length determination region; other site 196164001719 substrate-Mg2+ binding site; other site 196164001720 catalytic residues [active] 196164001721 aspartate-rich region 1; other site 196164001722 active site lid residues [active] 196164001723 aspartate-rich region 2; other site 196164001724 Helix-turn-helix domains; Region: HTH; cl00088 196164001725 Lipocalin / cytosolic fatty-acid binding protein family; Region: Lipocalin; cl01150 196164001726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001727 NAD(P) binding site [chemical binding]; other site 196164001728 active site 196164001729 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 196164001730 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 196164001731 DNA photolyase; Region: DNA_photolyase; pfam00875 196164001732 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 196164001733 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 196164001734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 196164001735 active site 196164001736 Bacterial membrane flanked domain; Region: DUF304; cl01348 196164001737 Predicted membrane protein [Function unknown]; Region: COG3428 196164001738 Bacterial PH domain; Region: DUF304; cl01348 196164001739 Bacterial PH domain; Region: DUF304; cl01348 196164001740 Bacterial PH domain; Region: DUF304; cl01348 196164001741 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 196164001742 Helix-turn-helix domains; Region: HTH; cl00088 196164001743 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 196164001744 FeoA domain; Region: FeoA; cl00838 196164001745 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 196164001746 NAD-dependent deacetylase; Provisional; Region: PRK05333 196164001747 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 196164001748 NAD+ binding site [chemical binding]; other site 196164001749 substrate binding site [chemical binding]; other site 196164001750 Zn binding site [ion binding]; other site 196164001751 hypothetical protein; Provisional; Region: PRK01617 196164001752 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 196164001753 nucleoside/Zn binding site; other site 196164001754 dimer interface [polypeptide binding]; other site 196164001755 catalytic motif [active] 196164001756 OpgC protein; Region: OpgC_C; cl00792 196164001757 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164001758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164001759 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 196164001760 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 196164001761 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 196164001762 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 196164001763 homodimer interface [polypeptide binding]; other site 196164001764 NADP binding site [chemical binding]; other site 196164001765 substrate binding site [chemical binding]; other site 196164001766 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 196164001767 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 196164001768 metabolite-proton symporter; Region: 2A0106; TIGR00883 196164001769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001770 putative substrate translocation pore; other site 196164001771 AMP-binding enzyme; Region: AMP-binding; cl15778 196164001772 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 196164001773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164001774 Helix-turn-helix domains; Region: HTH; cl00088 196164001775 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 196164001776 CoenzymeA binding site [chemical binding]; other site 196164001777 subunit interaction site [polypeptide binding]; other site 196164001778 PHB binding site; other site 196164001779 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 196164001780 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 196164001781 Phenylacetic acid degradation B; Region: PaaB; cl01371 196164001782 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 196164001783 Domain of unknown function DUF59; Region: DUF59; cl00941 196164001784 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 196164001785 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 196164001786 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 196164001787 FAD binding pocket [chemical binding]; other site 196164001788 FAD binding motif [chemical binding]; other site 196164001789 phosphate binding motif [ion binding]; other site 196164001790 beta-alpha-beta structure motif; other site 196164001791 NAD(p) ribose binding residues [chemical binding]; other site 196164001792 NAD binding pocket [chemical binding]; other site 196164001793 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 196164001794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196164001795 catalytic loop [active] 196164001796 iron binding site [ion binding]; other site 196164001797 enoyl-CoA hydratase; Provisional; Region: PRK06688 196164001798 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164001799 substrate binding site [chemical binding]; other site 196164001800 oxyanion hole (OAH) forming residues; other site 196164001801 trimer interface [polypeptide binding]; other site 196164001802 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 196164001803 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196164001804 dimer interface [polypeptide binding]; other site 196164001805 active site 196164001806 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 196164001807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164001808 substrate binding site [chemical binding]; other site 196164001809 oxyanion hole (OAH) forming residues; other site 196164001810 trimer interface [polypeptide binding]; other site 196164001811 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 196164001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164001813 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 196164001814 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 196164001815 CoenzymeA binding site [chemical binding]; other site 196164001816 subunit interaction site [polypeptide binding]; other site 196164001817 PHB binding site; other site 196164001818 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 196164001819 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 196164001820 substrate binding site [chemical binding]; other site 196164001821 dimer interface [polypeptide binding]; other site 196164001822 NADP binding site [chemical binding]; other site 196164001823 catalytic residues [active] 196164001824 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 196164001825 substrate binding site [chemical binding]; other site 196164001826 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 196164001827 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 196164001828 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05613 196164001829 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196164001830 homodimer interface [polypeptide binding]; other site 196164001831 substrate-cofactor binding pocket; other site 196164001832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164001833 catalytic residue [active] 196164001834 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 196164001835 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 196164001836 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196164001837 FAD binding pocket [chemical binding]; other site 196164001838 FAD binding motif [chemical binding]; other site 196164001839 phosphate binding motif [ion binding]; other site 196164001840 NAD binding pocket [chemical binding]; other site 196164001841 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196164001842 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196164001843 Walker A/P-loop; other site 196164001844 ATP binding site [chemical binding]; other site 196164001845 Q-loop/lid; other site 196164001846 ABC transporter signature motif; other site 196164001847 Walker B; other site 196164001848 D-loop; other site 196164001849 H-loop/switch region; other site 196164001850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164001851 ABC-ATPase subunit interface; other site 196164001852 dimer interface [polypeptide binding]; other site 196164001853 putative PBP binding regions; other site 196164001854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164001855 ABC-ATPase subunit interface; other site 196164001856 dimer interface [polypeptide binding]; other site 196164001857 putative PBP binding regions; other site 196164001858 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 196164001859 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196164001860 siderophore binding site; other site 196164001861 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196164001862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001863 putative substrate translocation pore; other site 196164001864 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 196164001865 putative catalytic site [active] 196164001866 putative metal binding site [ion binding]; other site 196164001867 putative phosphate binding site [ion binding]; other site 196164001868 Predicted membrane protein [Function unknown]; Region: COG2860 196164001869 UPF0126 domain; Region: UPF0126; pfam03458 196164001870 UPF0126 domain; Region: UPF0126; pfam03458 196164001871 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 196164001872 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196164001873 intersubunit interface [polypeptide binding]; other site 196164001874 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196164001875 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196164001876 Walker A/P-loop; other site 196164001877 ATP binding site [chemical binding]; other site 196164001878 Q-loop/lid; other site 196164001879 ABC transporter signature motif; other site 196164001880 Walker B; other site 196164001881 D-loop; other site 196164001882 H-loop/switch region; other site 196164001883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164001884 ABC-ATPase subunit interface; other site 196164001885 dimer interface [polypeptide binding]; other site 196164001886 putative PBP binding regions; other site 196164001887 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 196164001888 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 196164001889 active site 196164001890 HIGH motif; other site 196164001891 dimer interface [polypeptide binding]; other site 196164001892 KMSKS motif; other site 196164001893 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 196164001894 RDD family; Region: RDD; cl00746 196164001895 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 196164001896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164001897 NlpC/P60 family; Region: NLPC_P60; cl11438 196164001898 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164001899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164001900 non-specific DNA binding site [nucleotide binding]; other site 196164001901 salt bridge; other site 196164001902 sequence-specific DNA binding site [nucleotide binding]; other site 196164001903 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 196164001904 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 196164001905 active site 196164001906 substrate binding site [chemical binding]; other site 196164001907 metal binding site [ion binding]; metal-binding site 196164001908 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196164001909 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 196164001910 metal binding site [ion binding]; metal-binding site 196164001911 putative dimer interface [polypeptide binding]; other site 196164001912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001913 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 196164001914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 196164001915 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196164001916 pyruvate carboxylase; Reviewed; Region: PRK12999 196164001917 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196164001918 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164001919 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 196164001920 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 196164001921 active site 196164001922 catalytic residues [active] 196164001923 metal binding site [ion binding]; metal-binding site 196164001924 homodimer binding site [polypeptide binding]; other site 196164001925 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 196164001926 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196164001927 carboxyltransferase (CT) interaction site; other site 196164001928 biotinylation site [posttranslational modification]; other site 196164001929 allophanate hydrolase; Provisional; Region: PRK08186 196164001930 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 196164001931 Amino acid permease; Region: AA_permease; cl00524 196164001932 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 196164001933 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 196164001934 urea carboxylase; Region: urea_carbox; TIGR02712 196164001935 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196164001936 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164001937 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 196164001938 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 196164001939 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 196164001940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196164001941 carboxyltransferase (CT) interaction site; other site 196164001942 biotinylation site [posttranslational modification]; other site 196164001943 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 196164001944 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 196164001945 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 196164001946 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 196164001947 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196164001948 tetramer interface [polypeptide binding]; other site 196164001949 active site 196164001950 Mg2+/Mn2+ binding site [ion binding]; other site 196164001951 citrate synthase; Provisional; Region: PRK14033 196164001952 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 196164001953 dimer interface [polypeptide binding]; other site 196164001954 active site 196164001955 citrylCoA binding site [chemical binding]; other site 196164001956 oxalacetate/citrate binding site [chemical binding]; other site 196164001957 coenzyme A binding site [chemical binding]; other site 196164001958 catalytic triad [active] 196164001959 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164001960 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 196164001961 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196164001962 carboxyltransferase (CT) interaction site; other site 196164001963 biotinylation site [posttranslational modification]; other site 196164001964 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 196164001965 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 196164001966 active site residue [active] 196164001967 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 196164001968 active site residue [active] 196164001969 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164001970 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 196164001971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164001972 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 196164001973 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 196164001974 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 196164001975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164001976 substrate binding site [chemical binding]; other site 196164001977 oxyanion hole (OAH) forming residues; other site 196164001978 trimer interface [polypeptide binding]; other site 196164001979 acyl-coenzyme A oxidase; Region: PLN02526 196164001980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196164001981 active site 196164001982 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 196164001983 active site 196164001984 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 196164001985 CoA-transferase family III; Region: CoA_transf_3; pfam02515 196164001986 Helix-turn-helix domains; Region: HTH; cl00088 196164001987 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 196164001988 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 196164001989 dimerization interface [polypeptide binding]; other site 196164001990 substrate binding pocket [chemical binding]; other site 196164001991 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 196164001992 DctM-like transporters; Region: DctM; pfam06808 196164001993 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 196164001994 acyl-coenzyme A oxidase; Region: PLN02526 196164001995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196164001996 active site 196164001997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164001998 putative substrate translocation pore; other site 196164001999 putative acyltransferase; Provisional; Region: PRK05790 196164002000 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196164002001 dimer interface [polypeptide binding]; other site 196164002002 active site 196164002003 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 196164002004 OpgC protein; Region: OpgC_C; cl00792 196164002005 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 196164002006 putative catalytic site [active] 196164002007 putative phosphate binding site [ion binding]; other site 196164002008 putative metal binding site [ion binding]; other site 196164002009 Maf-like protein; Region: Maf; pfam02545 196164002010 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 196164002011 active site 196164002012 dimer interface [polypeptide binding]; other site 196164002013 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 196164002014 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 196164002015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002017 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 196164002018 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002019 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002020 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 196164002021 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 196164002022 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 196164002023 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 196164002024 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164002025 AIR carboxylase; Region: AIRC; cl00310 196164002026 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 196164002027 putative active site [active] 196164002028 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 196164002029 NADP+ binding site [chemical binding]; other site 196164002030 folate binding site [chemical binding]; other site 196164002031 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196164002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164002033 dimer interface [polypeptide binding]; other site 196164002034 conserved gate region; other site 196164002035 putative PBP binding loops; other site 196164002036 ABC-ATPase subunit interface; other site 196164002037 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196164002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164002039 dimer interface [polypeptide binding]; other site 196164002040 conserved gate region; other site 196164002041 putative PBP binding loops; other site 196164002042 ABC-ATPase subunit interface; other site 196164002043 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 196164002044 putative hydrophobic ligand binding site [chemical binding]; other site 196164002045 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 196164002046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164002047 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164002048 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196164002049 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 196164002050 Walker A/P-loop; other site 196164002051 ATP binding site [chemical binding]; other site 196164002052 Q-loop/lid; other site 196164002053 ABC transporter signature motif; other site 196164002054 Walker B; other site 196164002055 D-loop; other site 196164002056 H-loop/switch region; other site 196164002057 TOBE domain; Region: TOBE_2; cl01440 196164002058 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164002059 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 196164002060 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 196164002061 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 196164002062 Probable Catalytic site; other site 196164002063 metal-binding site 196164002064 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 196164002065 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 196164002066 active site 196164002067 Substrate binding site; other site 196164002068 Mg++ binding site; other site 196164002069 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196164002070 Transcription factor WhiB; Region: Whib; pfam02467 196164002071 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 196164002072 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 196164002073 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 196164002074 active site 196164002075 substrate binding site [chemical binding]; other site 196164002076 metal binding site [ion binding]; metal-binding site 196164002077 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 196164002078 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 196164002079 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 196164002080 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 196164002081 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 196164002082 oligomerization interface [polypeptide binding]; other site 196164002083 active site 196164002084 NAD+ binding site [chemical binding]; other site 196164002085 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 196164002086 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 196164002087 TMP-binding site; other site 196164002088 ATP-binding site [chemical binding]; other site 196164002089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196164002090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164002091 active site 196164002092 phosphorylation site [posttranslational modification] 196164002093 intermolecular recognition site; other site 196164002094 dimerization interface [polypeptide binding]; other site 196164002095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196164002096 DNA binding site [nucleotide binding] 196164002097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196164002098 dimerization interface [polypeptide binding]; other site 196164002099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196164002100 dimer interface [polypeptide binding]; other site 196164002101 phosphorylation site [posttranslational modification] 196164002102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164002103 ATP binding site [chemical binding]; other site 196164002104 Mg2+ binding site [ion binding]; other site 196164002105 G-X-G motif; other site 196164002106 lipoprotein LpqB; Provisional; Region: PRK13616 196164002107 Sporulation and spore germination; Region: Germane; cl11253 196164002108 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 196164002109 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164002110 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 196164002111 30S subunit binding site; other site 196164002112 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 196164002113 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002114 ATP binding site [chemical binding]; other site 196164002115 putative Mg++ binding site [ion binding]; other site 196164002116 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 196164002117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164002118 nucleotide binding region [chemical binding]; other site 196164002119 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164002120 Predicted GTPases [General function prediction only]; Region: COG1162 196164002121 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 196164002122 GTPase/OB domain interface [polypeptide binding]; other site 196164002123 GTPase/Zn-binding domain interface [polypeptide binding]; other site 196164002124 GTP/Mg2+ binding site [chemical binding]; other site 196164002125 G4 box; other site 196164002126 G5 box; other site 196164002127 G1 box; other site 196164002128 Switch I region; other site 196164002129 G2 box; other site 196164002130 G3 box; other site 196164002131 Switch II region; other site 196164002132 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 196164002133 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 196164002134 hinge; other site 196164002135 active site 196164002136 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 196164002137 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196164002138 active site 196164002139 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 196164002140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164002141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164002142 DNA binding residues [nucleotide binding] 196164002143 Transcription factor WhiB; Region: Whib; pfam02467 196164002144 PQQ-like domain; Region: PQQ_2; pfam13360 196164002145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002146 ATP binding site [chemical binding]; other site 196164002147 putative Mg++ binding site [ion binding]; other site 196164002148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164002149 nucleotide binding region [chemical binding]; other site 196164002150 ATP-binding site [chemical binding]; other site 196164002151 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 196164002152 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 196164002153 TIGR02569 family protein; Region: TIGR02569_actnb 196164002154 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196164002155 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002156 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 196164002157 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196164002158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002159 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 196164002160 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 196164002161 Ion channel; Region: Ion_trans_2; cl11596 196164002162 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 196164002163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002164 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 196164002165 putative NADH binding site [chemical binding]; other site 196164002166 putative active site [active] 196164002167 nudix motif; other site 196164002168 putative metal binding site [ion binding]; other site 196164002169 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 196164002170 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002171 HRDC domain; Region: HRDC; cl02578 196164002172 Protein of unknown function DUF45; Region: DUF45; cl00636 196164002173 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 196164002174 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 196164002175 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 196164002176 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 196164002177 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 196164002178 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 196164002179 oxaloacetate decarboxylase; Provisional; Region: PRK12330 196164002180 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 196164002181 active site 196164002182 catalytic residues [active] 196164002183 metal binding site [ion binding]; metal-binding site 196164002184 homodimer binding site [polypeptide binding]; other site 196164002185 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 196164002186 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 196164002187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002188 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002189 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 196164002190 carboxyltransferase (CT) interaction site; other site 196164002191 biotinylation site [posttranslational modification]; other site 196164002192 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164002193 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 196164002194 active site 196164002195 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 196164002196 active site 196164002197 peptide chain release factor 2; Validated; Region: prfB; PRK00578 196164002198 Proline dehydrogenase; Region: Pro_dh; cl03282 196164002199 RF-1 domain; Region: RF-1; cl02875 196164002200 RF-1 domain; Region: RF-1; cl02875 196164002201 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 196164002202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002203 Walker A/P-loop; other site 196164002204 ATP binding site [chemical binding]; other site 196164002205 Q-loop/lid; other site 196164002206 ABC transporter signature motif; other site 196164002207 Walker B; other site 196164002208 D-loop; other site 196164002209 H-loop/switch region; other site 196164002210 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 196164002211 FtsX-like permease family; Region: FtsX; pfam02687 196164002212 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 196164002213 SmpB-tmRNA interface; other site 196164002214 Protein of unknown function, DUF488; Region: DUF488; cl01246 196164002215 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196164002216 Phage integrase family; Region: Phage_integrase; pfam00589 196164002217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196164002218 DNA binding site [nucleotide binding] 196164002219 Int/Topo IB signature motif; other site 196164002220 active site 196164002221 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164002222 Protein of unknown function (DUF433); Region: DUF433; cl01030 196164002223 Domain of unknown function (DUF955); Region: DUF955; cl01076 196164002224 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164002225 BRO family, N-terminal domain; Region: Bro-N; cl10591 196164002226 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 196164002227 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 196164002228 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164002229 DNA binding residues [nucleotide binding] 196164002230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002231 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 196164002232 Protein of unknown function (DUF935); Region: DUF935; pfam06074 196164002233 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 196164002234 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 196164002235 Phage-related protein [Function unknown]; Region: COG5412 196164002236 Right handed beta helix region; Region: Beta_helix; pfam13229 196164002237 Right handed beta helix region; Region: Beta_helix; pfam13229 196164002238 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 196164002239 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 196164002240 active site 196164002241 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 196164002242 amidase catalytic site [active] 196164002243 Zn binding residues [ion binding]; other site 196164002244 substrate binding site [chemical binding]; other site 196164002245 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 196164002246 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 196164002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164002248 dimer interface [polypeptide binding]; other site 196164002249 conserved gate region; other site 196164002250 putative PBP binding loops; other site 196164002251 ABC-ATPase subunit interface; other site 196164002252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164002253 dimer interface [polypeptide binding]; other site 196164002254 conserved gate region; other site 196164002255 putative PBP binding loops; other site 196164002256 ABC-ATPase subunit interface; other site 196164002257 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 196164002258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164002259 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196164002260 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 196164002261 Walker A/P-loop; other site 196164002262 ATP binding site [chemical binding]; other site 196164002263 Q-loop/lid; other site 196164002264 ABC transporter signature motif; other site 196164002265 Walker B; other site 196164002266 D-loop; other site 196164002267 H-loop/switch region; other site 196164002268 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196164002269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002270 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164002271 dimerization interface [polypeptide binding]; other site 196164002272 putative DNA binding site [nucleotide binding]; other site 196164002273 putative Zn2+ binding site [ion binding]; other site 196164002274 Membrane transport protein; Region: Mem_trans; cl09117 196164002275 Low molecular weight phosphatase family; Region: LMWPc; cl00105 196164002276 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 196164002277 active site 196164002278 Low molecular weight phosphatase family; Region: LMWPc; cl00105 196164002279 active site 196164002280 Low molecular weight phosphatase family; Region: LMWPc; cl00105 196164002281 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 196164002282 active site 196164002283 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 196164002284 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 196164002285 dimer interface [polypeptide binding]; other site 196164002286 putative radical transfer pathway; other site 196164002287 diiron center [ion binding]; other site 196164002288 tyrosyl radical; other site 196164002289 Vitamin K epoxide reductase family; Region: VKOR; cl01729 196164002290 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 196164002291 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 196164002292 putative ligand binding residues [chemical binding]; other site 196164002293 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164002294 ABC-ATPase subunit interface; other site 196164002295 dimer interface [polypeptide binding]; other site 196164002296 putative PBP binding regions; other site 196164002297 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164002298 ABC-ATPase subunit interface; other site 196164002299 dimer interface [polypeptide binding]; other site 196164002300 putative PBP binding regions; other site 196164002301 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 196164002302 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196164002303 Walker A/P-loop; other site 196164002304 ATP binding site [chemical binding]; other site 196164002305 Q-loop/lid; other site 196164002306 ABC transporter signature motif; other site 196164002307 Walker B; other site 196164002308 D-loop; other site 196164002309 H-loop/switch region; other site 196164002310 aminotransferase; Validated; Region: PRK07777 196164002311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164002312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164002313 homodimer interface [polypeptide binding]; other site 196164002314 catalytic residue [active] 196164002315 Protein of unknown function (DUF456); Region: DUF456; cl01069 196164002316 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 196164002317 DNA repair helicase rad25; Region: rad25; TIGR00603 196164002318 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 196164002319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164002320 ATP binding site [chemical binding]; other site 196164002321 putative Mg++ binding site [ion binding]; other site 196164002322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164002323 nucleotide binding region [chemical binding]; other site 196164002324 ATP-binding site [chemical binding]; other site 196164002325 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 196164002326 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 196164002327 Protein of unknown function (DUF3235); Region: DUF3235; pfam11574 196164002328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 196164002329 DNA-binding site [nucleotide binding]; DNA binding site 196164002330 RNA-binding motif; other site 196164002331 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 196164002332 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 196164002333 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 196164002334 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196164002335 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 196164002336 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 196164002337 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 196164002338 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196164002339 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 196164002340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196164002341 catalytic residue [active] 196164002342 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 196164002343 dimer interface [polypeptide binding]; other site 196164002344 Citrate synthase; Region: Citrate_synt; pfam00285 196164002345 active site 196164002346 citrylCoA binding site [chemical binding]; other site 196164002347 NADH binding [chemical binding]; other site 196164002348 cationic pore residues; other site 196164002349 oxalacetate/citrate binding site [chemical binding]; other site 196164002350 coenzyme A binding site [chemical binding]; other site 196164002351 catalytic triad [active] 196164002352 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 196164002353 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 196164002354 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164002356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196164002357 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 196164002358 active site 196164002359 catalytic tetrad [active] 196164002360 Protein of unknown function, DUF485; Region: DUF485; cl01231 196164002361 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 196164002362 Sodium:solute symporter family; Region: SSF; cl00456 196164002363 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 196164002364 active site 196164002365 Acyl transferase domain; Region: Acyl_transf_1; cl08282 196164002366 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 196164002367 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 196164002368 phosphate binding site [ion binding]; other site 196164002369 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 196164002370 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 196164002371 putative active site [active] 196164002372 putative catalytic site [active] 196164002373 Acyl transferase domain; Region: Acyl_transf_1; cl08282 196164002374 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 196164002375 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 196164002376 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 196164002377 putative NAD(P) binding site [chemical binding]; other site 196164002378 active site 196164002379 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 196164002380 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 196164002381 active site 196164002382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164002383 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196164002384 putative substrate translocation pore; other site 196164002385 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164002386 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164002387 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 196164002388 catalytic residues [active] 196164002389 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 196164002390 folate binding site [chemical binding]; other site 196164002391 NADP+ binding site [chemical binding]; other site 196164002392 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 196164002393 dimerization interface [polypeptide binding]; other site 196164002394 active site 196164002395 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 196164002396 active site 196164002397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164002398 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 196164002399 ATP binding site [chemical binding]; other site 196164002400 putative Mg++ binding site [ion binding]; other site 196164002401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164002402 nucleotide binding region [chemical binding]; other site 196164002403 ATP-binding site [chemical binding]; other site 196164002404 DEAD/H associated; Region: DEAD_assoc; pfam08494 196164002405 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 196164002406 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 196164002407 putative DNA binding site [nucleotide binding]; other site 196164002408 catalytic residue [active] 196164002409 putative H2TH interface [polypeptide binding]; other site 196164002410 putative catalytic residues [active] 196164002411 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196164002412 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196164002413 hypothetical protein; Provisional; Region: PRK11770 196164002414 Domain of unknown function (DUF307); Region: DUF307; pfam03733 196164002415 Domain of unknown function (DUF307); Region: DUF307; pfam03733 196164002416 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 196164002417 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196164002418 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 196164002419 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 196164002420 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 196164002421 active site 196164002422 dimer interface [polypeptide binding]; other site 196164002423 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 196164002424 dimer interface [polypeptide binding]; other site 196164002425 active site 196164002426 Chorismate mutase type II; Region: CM_2; cl00693 196164002427 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 196164002428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002429 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 196164002430 FtsX-like permease family; Region: FtsX; pfam02687 196164002431 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196164002432 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 196164002433 Walker A/P-loop; other site 196164002434 ATP binding site [chemical binding]; other site 196164002435 Q-loop/lid; other site 196164002436 ABC transporter signature motif; other site 196164002437 Walker B; other site 196164002438 D-loop; other site 196164002439 H-loop/switch region; other site 196164002440 Helix-turn-helix domains; Region: HTH; cl00088 196164002441 Peptidase family M23; Region: Peptidase_M23; pfam01551 196164002442 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 196164002443 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 196164002444 active site 196164002445 substrate binding site [chemical binding]; other site 196164002446 cosubstrate binding site; other site 196164002447 catalytic site [active] 196164002448 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 196164002449 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 196164002450 purine monophosphate binding site [chemical binding]; other site 196164002451 dimer interface [polypeptide binding]; other site 196164002452 putative catalytic residues [active] 196164002453 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 196164002454 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 196164002455 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 196164002456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164002457 Helix-turn-helix domains; Region: HTH; cl00088 196164002458 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 196164002459 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 196164002460 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 196164002461 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 196164002462 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 196164002463 Permease family; Region: Xan_ur_permease; cl00967 196164002464 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 196164002465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164002466 dimerization interface [polypeptide binding]; other site 196164002467 putative DNA binding site [nucleotide binding]; other site 196164002468 putative Zn2+ binding site [ion binding]; other site 196164002469 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 196164002470 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 196164002471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196164002472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164002473 active site 196164002474 phosphorylation site [posttranslational modification] 196164002475 intermolecular recognition site; other site 196164002476 dimerization interface [polypeptide binding]; other site 196164002477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196164002478 DNA binding site [nucleotide binding] 196164002479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196164002480 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196164002481 dimerization interface [polypeptide binding]; other site 196164002482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196164002483 dimer interface [polypeptide binding]; other site 196164002484 phosphorylation site [posttranslational modification] 196164002485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164002486 ATP binding site [chemical binding]; other site 196164002487 Mg2+ binding site [ion binding]; other site 196164002488 G-X-G motif; other site 196164002489 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 196164002490 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164002491 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 196164002492 protein binding site [polypeptide binding]; other site 196164002493 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 196164002494 MPT binding site; other site 196164002495 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 196164002496 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 196164002497 SAF domain; Region: SAF; cl00555 196164002498 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 196164002499 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 196164002500 active site 196164002501 tetramer interface; other site 196164002502 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196164002503 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196164002504 dimer interface [polypeptide binding]; other site 196164002505 putative functional site; other site 196164002506 putative MPT binding site; other site 196164002507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196164002508 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164002509 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 196164002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164002511 putative substrate translocation pore; other site 196164002512 DoxX; Region: DoxX; cl00976 196164002513 Anti-sigma-K factor rskA; Region: RskA; cl15366 196164002514 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 196164002515 active site 196164002516 catalytic site [active] 196164002517 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 196164002518 Predicted methyltransferases [General function prediction only]; Region: COG0313 196164002519 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 196164002520 BCCT family transporter; Region: BCCT; cl00569 196164002521 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 196164002522 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 196164002523 active site 196164002524 HIGH motif; other site 196164002525 KMSKS motif; other site 196164002526 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 196164002527 tRNA binding surface [nucleotide binding]; other site 196164002528 anticodon binding site; other site 196164002529 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 196164002530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164002531 ATP binding site [chemical binding]; other site 196164002532 putative Mg++ binding site [ion binding]; other site 196164002533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164002534 nucleotide binding region [chemical binding]; other site 196164002535 ATP-binding site [chemical binding]; other site 196164002536 Putative cyclase; Region: Cyclase; cl00814 196164002537 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 196164002538 active site 196164002539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 196164002540 Domain of unknown function (DUF348); Region: DUF348; pfam03990 196164002541 Domain of unknown function (DUF348); Region: DUF348; pfam03990 196164002542 Domain of unknown function (DUF348); Region: DUF348; pfam03990 196164002543 G5 domain; Region: G5; pfam07501 196164002544 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 196164002545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164002546 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 196164002547 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 196164002548 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196164002549 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164002550 ABC transporter; Region: ABC_tran_2; pfam12848 196164002551 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164002552 Mnd1 family; Region: Mnd1; pfam03962 196164002553 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 196164002554 dimer interface [polypeptide binding]; other site 196164002555 pyridoxal binding site [chemical binding]; other site 196164002556 ATP binding site [chemical binding]; other site 196164002557 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 196164002558 catalytic residues [active] 196164002559 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 196164002560 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 196164002561 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 196164002562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164002563 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 196164002564 active site 196164002565 motif I; other site 196164002566 motif II; other site 196164002567 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164002568 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 196164002569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164002570 substrate binding site [chemical binding]; other site 196164002571 oxyanion hole (OAH) forming residues; other site 196164002572 trimer interface [polypeptide binding]; other site 196164002573 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 196164002574 Predicted esterase [General function prediction only]; Region: COG0627 196164002575 Helix-turn-helix domains; Region: HTH; cl00088 196164002576 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 196164002577 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 196164002578 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 196164002579 NAD(P) binding site [chemical binding]; other site 196164002580 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 196164002581 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 196164002582 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 196164002583 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 196164002584 G1 box; other site 196164002585 putative GEF interaction site [polypeptide binding]; other site 196164002586 GTP/Mg2+ binding site [chemical binding]; other site 196164002587 Switch I region; other site 196164002588 G2 box; other site 196164002589 G3 box; other site 196164002590 Switch II region; other site 196164002591 G4 box; other site 196164002592 G5 box; other site 196164002593 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 196164002594 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 196164002595 alpha-gamma subunit interface [polypeptide binding]; other site 196164002596 beta-gamma subunit interface [polypeptide binding]; other site 196164002597 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 196164002598 gamma-beta subunit interface [polypeptide binding]; other site 196164002599 alpha-beta subunit interface [polypeptide binding]; other site 196164002600 urease subunit alpha; Reviewed; Region: ureC; PRK13207 196164002601 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 196164002602 subunit interactions [polypeptide binding]; other site 196164002603 active site 196164002604 flap region; other site 196164002605 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 196164002606 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 196164002607 dimer interface [polypeptide binding]; other site 196164002608 catalytic residues [active] 196164002609 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 196164002610 UreF; Region: UreF; pfam01730 196164002611 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002612 UreD urease accessory protein; Region: UreD; cl00530 196164002613 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 196164002614 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 196164002615 putative ligand binding site [chemical binding]; other site 196164002616 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 196164002617 TM-ABC transporter signature motif; other site 196164002618 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 196164002619 TM-ABC transporter signature motif; other site 196164002620 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 196164002621 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 196164002622 Walker A/P-loop; other site 196164002623 ATP binding site [chemical binding]; other site 196164002624 Q-loop/lid; other site 196164002625 ABC transporter signature motif; other site 196164002626 Walker B; other site 196164002627 D-loop; other site 196164002628 H-loop/switch region; other site 196164002629 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 196164002630 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 196164002631 Walker A/P-loop; other site 196164002632 ATP binding site [chemical binding]; other site 196164002633 Q-loop/lid; other site 196164002634 ABC transporter signature motif; other site 196164002635 Walker B; other site 196164002636 D-loop; other site 196164002637 H-loop/switch region; other site 196164002638 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 196164002639 putative active site [active] 196164002640 catalytic residue [active] 196164002641 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 196164002642 Nitronate monooxygenase; Region: NMO; pfam03060 196164002643 FMN binding site [chemical binding]; other site 196164002644 substrate binding site [chemical binding]; other site 196164002645 putative catalytic residue [active] 196164002646 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 196164002647 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 196164002648 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196164002649 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 196164002650 putative active site [active] 196164002651 catalytic residue [active] 196164002652 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 196164002653 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 196164002654 5S rRNA interface [nucleotide binding]; other site 196164002655 CTC domain interface [polypeptide binding]; other site 196164002656 L16 interface [polypeptide binding]; other site 196164002657 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 196164002658 active site 196164002659 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 196164002660 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 196164002661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 196164002662 active site 196164002663 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 196164002664 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 196164002665 Substrate binding site; other site 196164002666 Mg++ binding site; other site 196164002667 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 196164002668 active site 196164002669 substrate binding site [chemical binding]; other site 196164002670 CoA binding site [chemical binding]; other site 196164002671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164002672 putative substrate translocation pore; other site 196164002673 multicopper oxidase; Provisional; Region: PRK10965 196164002674 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 196164002675 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 196164002676 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164002677 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 196164002678 Walker A/P-loop; other site 196164002679 ATP binding site [chemical binding]; other site 196164002680 Q-loop/lid; other site 196164002681 ABC transporter signature motif; other site 196164002682 Walker B; other site 196164002683 D-loop; other site 196164002684 H-loop/switch region; other site 196164002685 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 196164002686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196164002687 Histidine kinase; Region: HisKA_3; pfam07730 196164002688 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164002689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164002690 active site 196164002691 phosphorylation site [posttranslational modification] 196164002692 intermolecular recognition site; other site 196164002693 dimerization interface [polypeptide binding]; other site 196164002694 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164002695 DNA binding residues [nucleotide binding] 196164002696 dimerization interface [polypeptide binding]; other site 196164002697 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 196164002698 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164002699 MULE transposase domain; Region: MULE; pfam10551 196164002700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 196164002701 Integrase core domain; Region: rve; cl01316 196164002702 Uncharacterized conserved protein [Function unknown]; Region: COG4715 196164002703 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 196164002704 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 196164002705 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 196164002706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164002707 Helix-turn-helix domains; Region: HTH; cl00088 196164002708 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 196164002709 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 196164002710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164002711 ATP binding site [chemical binding]; other site 196164002712 putative Mg++ binding site [ion binding]; other site 196164002713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164002714 nucleotide binding region [chemical binding]; other site 196164002715 ATP-binding site [chemical binding]; other site 196164002716 TRCF domain; Region: TRCF; cl04088 196164002717 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 196164002718 Spore germination protein; Region: Spore_permease; cl15802 196164002719 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 196164002720 Alpha helical Porin B; Region: PorB; pfam11565 196164002721 Alpha helical Porin B; Region: PorB; pfam11565 196164002722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 196164002723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 196164002724 enolase; Provisional; Region: eno; PRK00077 196164002725 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 196164002726 dimer interface [polypeptide binding]; other site 196164002727 metal binding site [ion binding]; metal-binding site 196164002728 substrate binding pocket [chemical binding]; other site 196164002729 Septum formation initiator; Region: DivIC; cl11433 196164002730 Protein of unknown function (DUF501); Region: DUF501; cl00652 196164002731 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 196164002732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 196164002733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196164002734 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 196164002735 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 196164002736 domain; Region: GreA_GreB_N; pfam03449 196164002737 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 196164002738 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 196164002739 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 196164002740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002741 active site 196164002742 NeuB family; Region: NeuB; cl00496 196164002743 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 196164002744 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 196164002745 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 196164002746 catalytic residue [active] 196164002747 putative FPP diphosphate binding site; other site 196164002748 putative FPP binding hydrophobic cleft; other site 196164002749 dimer interface [polypeptide binding]; other site 196164002750 putative IPP diphosphate binding site; other site 196164002751 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 196164002752 pantothenate kinase; Provisional; Region: PRK05439 196164002753 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 196164002754 ATP-binding site [chemical binding]; other site 196164002755 CoA-binding site [chemical binding]; other site 196164002756 Mg2+-binding site [ion binding]; other site 196164002757 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 196164002758 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 196164002759 dimer interface [polypeptide binding]; other site 196164002760 glycine-pyridoxal phosphate binding site [chemical binding]; other site 196164002761 active site 196164002762 folate binding site [chemical binding]; other site 196164002763 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 196164002764 Glutamine amidotransferase class-I; Region: GATase; pfam00117 196164002765 glutamine binding [chemical binding]; other site 196164002766 catalytic triad [active] 196164002767 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 196164002768 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 196164002769 chorismate binding enzyme; Region: Chorismate_bind; cl10555 196164002770 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 196164002771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164002772 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 196164002773 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164002774 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 196164002775 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 196164002776 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 196164002777 LamB/YcsF family; Region: LamB_YcsF; cl00664 196164002778 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 196164002779 Transcriptional regulators [Transcription]; Region: GntR; COG1802 196164002780 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164002781 DNA-binding site [nucleotide binding]; DNA binding site 196164002782 FCD domain; Region: FCD; cl11656 196164002783 fumarate hydratase; Reviewed; Region: fumC; PRK00485 196164002784 Class II fumarases; Region: Fumarase_classII; cd01362 196164002785 active site 196164002786 tetramer interface [polypeptide binding]; other site 196164002787 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196164002788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164002789 DNA-binding site [nucleotide binding]; DNA binding site 196164002790 FCD domain; Region: FCD; cl11656 196164002791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 196164002792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 196164002793 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 196164002794 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 196164002795 putative active site [active] 196164002796 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 196164002797 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 196164002798 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 196164002799 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 196164002800 generic binding surface II; other site 196164002801 generic binding surface I; other site 196164002802 LytB protein; Region: LYTB; cl00507 196164002803 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 196164002804 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196164002805 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 196164002806 Domain of unknown function DUF20; Region: UPF0118; cl00465 196164002807 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 196164002808 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 196164002809 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196164002810 active site 196164002811 GTP-binding protein YchF; Reviewed; Region: PRK09601 196164002812 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 196164002813 G1 box; other site 196164002814 GTP/Mg2+ binding site [chemical binding]; other site 196164002815 Switch I region; other site 196164002816 G2 box; other site 196164002817 Switch II region; other site 196164002818 G3 box; other site 196164002819 G4 box; other site 196164002820 G5 box; other site 196164002821 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 196164002822 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 196164002823 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 196164002824 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 196164002825 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 196164002826 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164002827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164002828 motif II; other site 196164002829 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 196164002830 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 196164002831 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 196164002832 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 196164002833 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 196164002834 Protein of unknown function, DUF485; Region: DUF485; cl01231 196164002835 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 196164002836 Sodium:solute symporter family; Region: SSF; cl00456 196164002837 high affinity sulphate transporter 1; Region: sulP; TIGR00815 196164002838 Permease family; Region: Xan_ur_permease; cl00967 196164002839 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 196164002840 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 196164002841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002842 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 196164002843 putative catalytic site [active] 196164002844 putative metal binding site [ion binding]; other site 196164002845 putative phosphate binding site [ion binding]; other site 196164002846 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 196164002847 FMN binding site [chemical binding]; other site 196164002848 active site 196164002849 substrate binding site [chemical binding]; other site 196164002850 catalytic residue [active] 196164002851 tocopherol cyclase; Region: PLN02818 196164002852 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196164002853 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002854 Walker A/P-loop; other site 196164002855 ATP binding site [chemical binding]; other site 196164002856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002857 ATP binding site [chemical binding]; other site 196164002858 Q-loop/lid; other site 196164002859 Q-loop/lid; other site 196164002860 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164002861 ABC transporter signature motif; other site 196164002862 Walker B; other site 196164002863 D-loop; other site 196164002864 ABC transporter; Region: ABC_tran_2; pfam12848 196164002865 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164002866 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 196164002867 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 196164002868 Phosphotransferase enzyme family; Region: APH; pfam01636 196164002869 putative active site [active] 196164002870 putative substrate binding site [chemical binding]; other site 196164002871 ATP binding site [chemical binding]; other site 196164002872 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 196164002873 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 196164002874 metal ion-dependent adhesion site (MIDAS); other site 196164002875 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 196164002876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002877 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164002878 catalytic core [active] 196164002879 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 196164002880 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 196164002881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196164002882 Coenzyme A binding pocket [chemical binding]; other site 196164002883 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196164002884 tetramer interface [polypeptide binding]; other site 196164002885 active site 196164002886 Mg2+/Mn2+ binding site [ion binding]; other site 196164002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164002888 S-adenosylmethionine binding site [chemical binding]; other site 196164002889 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 196164002890 alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs; Region: 3alpha_HSD_SDR_c; cd05328 196164002891 NAD binding site [chemical binding]; other site 196164002892 active site 196164002893 homodimer interface [polypeptide binding]; other site 196164002894 oxidoreductase; Provisional; Region: PRK06128 196164002895 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 196164002896 NAD binding site [chemical binding]; other site 196164002897 metal binding site [ion binding]; metal-binding site 196164002898 active site 196164002899 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 196164002900 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 196164002901 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196164002902 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 196164002903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196164002904 catalytic residue [active] 196164002905 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 196164002906 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 196164002907 dimerization interface [polypeptide binding]; other site 196164002908 active site 196164002909 Quinolinate synthetase A protein; Region: NadA; cl00420 196164002910 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 196164002911 nudix motif; other site 196164002912 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 196164002913 Protein of unknown function, DUF488; Region: DUF488; cl01246 196164002914 Protein of unknown function, DUF606; Region: DUF606; cl01273 196164002915 Protein of unknown function, DUF606; Region: DUF606; cl01273 196164002916 Protein of unknown function, DUF606; Region: DUF606; cl01273 196164002917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164002918 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 196164002919 dimer interface [polypeptide binding]; other site 196164002920 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 196164002921 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 196164002922 thiamine pyrophosphate protein; Provisional; Region: PRK08273 196164002923 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 196164002924 PYR/PP interface [polypeptide binding]; other site 196164002925 tetramer interface [polypeptide binding]; other site 196164002926 dimer interface [polypeptide binding]; other site 196164002927 TPP binding site [chemical binding]; other site 196164002928 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 196164002929 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 196164002930 TPP-binding site [chemical binding]; other site 196164002931 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 196164002932 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 196164002933 NAD binding site [chemical binding]; other site 196164002934 catalytic Zn binding site [ion binding]; other site 196164002935 structural Zn binding site [ion binding]; other site 196164002936 Competence-damaged protein; Region: CinA; cl00666 196164002937 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 196164002938 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196164002939 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164002940 DNA-binding site [nucleotide binding]; DNA binding site 196164002941 UTRA domain; Region: UTRA; cl01230 196164002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164002943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164002944 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 196164002945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002947 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 196164002948 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 196164002949 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 196164002950 Walker A/P-loop; other site 196164002951 ATP binding site [chemical binding]; other site 196164002952 Q-loop/lid; other site 196164002953 ABC transporter signature motif; other site 196164002954 Walker B; other site 196164002955 D-loop; other site 196164002956 H-loop/switch region; other site 196164002957 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 196164002958 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 196164002959 Walker A/P-loop; other site 196164002960 ATP binding site [chemical binding]; other site 196164002961 Q-loop/lid; other site 196164002962 ABC transporter signature motif; other site 196164002963 Walker B; other site 196164002964 D-loop; other site 196164002965 H-loop/switch region; other site 196164002966 Cobalt transport protein; Region: CbiQ; cl00463 196164002967 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 196164002968 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002969 active site 196164002970 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 196164002971 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 196164002972 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 196164002973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002974 Walker A/P-loop; other site 196164002975 ATP binding site [chemical binding]; other site 196164002976 Q-loop/lid; other site 196164002977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002978 ABC transporter signature motif; other site 196164002979 Walker B; other site 196164002980 D-loop; other site 196164002981 H-loop/switch region; other site 196164002982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164002983 Walker A/P-loop; other site 196164002984 ATP binding site [chemical binding]; other site 196164002985 Q-loop/lid; other site 196164002986 ABC transporter; Region: ABC_tran; pfam00005 196164002987 ABC transporter signature motif; other site 196164002988 Walker B; other site 196164002989 D-loop; other site 196164002990 H-loop/switch region; other site 196164002991 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 196164002992 dimer interface [polypeptide binding]; other site 196164002993 catalytic triad [active] 196164002994 peroxidatic and resolving cysteines [active] 196164002995 Protein of unknown function (DUF808); Region: DUF808; cl01002 196164002996 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 196164002997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164002998 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 196164002999 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 196164003000 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 196164003001 nudix motif; other site 196164003002 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164003003 active site 196164003004 substrate binding sites [chemical binding]; other site 196164003005 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 196164003006 ArsC family; Region: ArsC; pfam03960 196164003007 catalytic residues [active] 196164003008 Uncharacterized membrane protein [Function unknown]; Region: COG3949 196164003009 Protein of unknown function (DUF402); Region: DUF402; cl00979 196164003010 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 196164003011 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 196164003012 G1 box; other site 196164003013 putative GEF interaction site [polypeptide binding]; other site 196164003014 GTP/Mg2+ binding site [chemical binding]; other site 196164003015 Switch I region; other site 196164003016 G2 box; other site 196164003017 G3 box; other site 196164003018 Switch II region; other site 196164003019 G4 box; other site 196164003020 G5 box; other site 196164003021 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 196164003022 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 196164003023 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 196164003024 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 196164003025 Ferredoxin [Energy production and conversion]; Region: COG1146 196164003026 4Fe-4S binding domain; Region: Fer4; cl02805 196164003027 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 196164003028 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164003029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164003030 homodimer interface [polypeptide binding]; other site 196164003031 catalytic residue [active] 196164003032 GtrA-like protein; Region: GtrA; cl00971 196164003033 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 196164003034 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 196164003035 putative trimer interface [polypeptide binding]; other site 196164003036 putative CoA binding site [chemical binding]; other site 196164003037 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196164003038 Amino acid permease; Region: AA_permease; cl00524 196164003039 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 196164003040 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196164003041 putative trimer interface [polypeptide binding]; other site 196164003042 putative CoA binding site [chemical binding]; other site 196164003043 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 196164003044 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 196164003045 metal binding site [ion binding]; metal-binding site 196164003046 putative dimer interface [polypeptide binding]; other site 196164003047 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 196164003048 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 196164003049 dihydropteroate synthase; Region: DHPS; TIGR01496 196164003050 substrate binding pocket [chemical binding]; other site 196164003051 dimer interface [polypeptide binding]; other site 196164003052 inhibitor binding site; inhibition site 196164003053 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 196164003054 Ligand binding site; other site 196164003055 Putative Catalytic site; other site 196164003056 DXD motif; other site 196164003057 DivIVA domain; Region: DivI1A_domain; TIGR03544 196164003058 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 196164003059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164003060 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 196164003061 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 196164003062 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 196164003063 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 196164003064 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196164003065 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 196164003066 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 196164003067 ligand binding site; other site 196164003068 oligomer interface; other site 196164003069 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 196164003070 dimer interface [polypeptide binding]; other site 196164003071 N-terminal domain interface [polypeptide binding]; other site 196164003072 sulfate 1 binding site; other site 196164003073 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 196164003074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003076 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 196164003077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164003078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164003079 DNA binding residues [nucleotide binding] 196164003080 Putative zinc-finger; Region: zf-HC2; cl15806 196164003081 sec-independent translocase; Provisional; Region: tatB; PRK00182 196164003082 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 196164003083 Domain of unknown function DUF59; Region: DUF59; cl00941 196164003084 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 196164003085 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 196164003086 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 196164003087 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 196164003088 MgtE intracellular N domain; Region: MgtE_N; cl15244 196164003089 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 196164003090 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196164003091 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 196164003092 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164003093 MULE transposase domain; Region: MULE; pfam10551 196164003094 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 196164003095 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 196164003096 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 196164003097 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 196164003098 TPP-binding site [chemical binding]; other site 196164003099 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 196164003100 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164003101 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164003102 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003103 Walker A/P-loop; other site 196164003104 ATP binding site [chemical binding]; other site 196164003105 Q-loop/lid; other site 196164003106 ABC transporter signature motif; other site 196164003107 Walker B; other site 196164003108 D-loop; other site 196164003109 H-loop/switch region; other site 196164003110 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164003111 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164003112 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003113 Walker A/P-loop; other site 196164003114 ATP binding site [chemical binding]; other site 196164003115 Q-loop/lid; other site 196164003116 ABC transporter signature motif; other site 196164003117 Walker B; other site 196164003118 D-loop; other site 196164003119 H-loop/switch region; other site 196164003120 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 196164003121 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196164003122 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196164003123 shikimate binding site; other site 196164003124 NAD(P) binding site [chemical binding]; other site 196164003125 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 196164003126 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 196164003127 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 196164003128 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164003129 substrate binding pocket [chemical binding]; other site 196164003130 catalytic triad [active] 196164003131 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 196164003132 GAF domain; Region: GAF; cl00853 196164003133 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 196164003134 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 196164003135 DXD motif; other site 196164003136 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 196164003137 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 196164003138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164003139 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 196164003140 anti sigma factor interaction site; other site 196164003141 regulatory phosphorylation site [posttranslational modification]; other site 196164003142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 196164003143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164003145 putative substrate translocation pore; other site 196164003146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003147 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164003148 putative substrate translocation pore; other site 196164003149 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 196164003150 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 196164003151 THF binding site; other site 196164003152 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 196164003153 substrate binding site [chemical binding]; other site 196164003154 THF binding site; other site 196164003155 zinc-binding site [ion binding]; other site 196164003156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164003157 non-specific DNA binding site [nucleotide binding]; other site 196164003158 salt bridge; other site 196164003159 sequence-specific DNA binding site [nucleotide binding]; other site 196164003160 Domain of unknown function (DUF955); Region: DUF955; cl01076 196164003161 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196164003162 Predicted membrane protein [Function unknown]; Region: COG2364 196164003163 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 196164003164 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 196164003165 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 196164003166 active site 196164003167 dimer interface [polypeptide binding]; other site 196164003168 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164003169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164003170 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 196164003171 Integrase core domain; Region: rve; cl01316 196164003172 Integrase core domain; Region: rve; cl01316 196164003173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164003174 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164003175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164003176 non-specific DNA binding site [nucleotide binding]; other site 196164003177 salt bridge; other site 196164003178 sequence-specific DNA binding site [nucleotide binding]; other site 196164003179 putative transposase OrfB; Reviewed; Region: PHA02517 196164003180 Integrase core domain; Region: rve; cl01316 196164003181 Helix-turn-helix domains; Region: HTH; cl00088 196164003182 putative transposase OrfB; Reviewed; Region: PHA02517 196164003183 Helix-turn-helix domains; Region: HTH; cl00088 196164003184 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 196164003185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164003186 Walker A motif; other site 196164003187 ATP binding site [chemical binding]; other site 196164003188 Walker B motif; other site 196164003189 putative transposase OrfB; Reviewed; Region: PHA02517 196164003190 Integrase core domain; Region: rve; cl01316 196164003191 Helix-turn-helix domains; Region: HTH; cl00088 196164003192 Integrase core domain; Region: rve; cl01316 196164003193 Helix-turn-helix domains; Region: HTH; cl00088 196164003194 putative transposase OrfB; Reviewed; Region: PHA02517 196164003195 Integrase core domain; Region: rve; cl01316 196164003196 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164003197 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164003198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164003199 non-specific DNA binding site [nucleotide binding]; other site 196164003200 salt bridge; other site 196164003201 sequence-specific DNA binding site [nucleotide binding]; other site 196164003202 transposase; Provisional; Region: PRK06526 196164003203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164003204 Walker A motif; other site 196164003205 ATP binding site [chemical binding]; other site 196164003206 Walker B motif; other site 196164003207 Helix-turn-helix domains; Region: HTH; cl00088 196164003208 putative transposase OrfB; Reviewed; Region: PHA02517 196164003209 Integrase core domain; Region: rve; cl01316 196164003210 putative transposase OrfB; Reviewed; Region: PHA02517 196164003211 Integrase core domain; Region: rve; cl01316 196164003212 Integrase core domain; Region: rve; cl01316 196164003213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 196164003214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 196164003215 Integrase core domain; Region: rve; cl01316 196164003216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164003217 Walker A motif; other site 196164003218 ATP binding site [chemical binding]; other site 196164003219 Walker B motif; other site 196164003220 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 196164003221 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 196164003222 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 196164003223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003224 Walker A/P-loop; other site 196164003225 ATP binding site [chemical binding]; other site 196164003226 Q-loop/lid; other site 196164003227 ABC transporter signature motif; other site 196164003228 Walker B; other site 196164003229 D-loop; other site 196164003230 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 196164003231 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164003232 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 196164003233 Walker A/P-loop; other site 196164003234 ATP binding site [chemical binding]; other site 196164003235 Q-loop/lid; other site 196164003236 ABC transporter signature motif; other site 196164003237 Walker B; other site 196164003238 D-loop; other site 196164003239 H-loop/switch region; other site 196164003240 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 196164003241 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 196164003242 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 196164003243 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 196164003244 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 196164003245 active site 196164003246 nucleophile elbow; other site 196164003247 Arginase family; Region: Arginase; cl00306 196164003248 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 196164003249 helicase 45; Provisional; Region: PTZ00424 196164003250 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 196164003251 ATP binding site [chemical binding]; other site 196164003252 Mg++ binding site [ion binding]; other site 196164003253 motif III; other site 196164003254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164003255 nucleotide binding region [chemical binding]; other site 196164003256 ATP-binding site [chemical binding]; other site 196164003257 DbpA RNA binding domain; Region: DbpA; pfam03880 196164003258 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 196164003259 Sodium:solute symporter family; Region: SSF; cl00456 196164003260 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 196164003261 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 196164003262 SNF2 Helicase protein; Region: DUF3670; pfam12419 196164003263 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 196164003264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164003265 putative Mg++ binding site [ion binding]; other site 196164003266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164003267 nucleotide binding region [chemical binding]; other site 196164003268 ATP-binding site [chemical binding]; other site 196164003269 SWIM zinc finger; Region: SWIM; cl15408 196164003270 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 196164003271 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 196164003272 active site 196164003273 metal binding site [ion binding]; metal-binding site 196164003274 DNA binding site [nucleotide binding] 196164003275 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 196164003276 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003277 chromosome segregation protein; Provisional; Region: PRK02224 196164003278 Uncharacterized conserved protein [Function unknown]; Region: COG4717 196164003279 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 196164003280 Helix-turn-helix domains; Region: HTH; cl00088 196164003281 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164003282 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164003283 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 196164003284 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 196164003285 active site 196164003286 DUF35 OB-fold domain; Region: DUF35; pfam01796 196164003287 YceI-like domain; Region: YceI; cl01001 196164003288 Helix-turn-helix domains; Region: HTH; cl00088 196164003289 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 196164003290 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164003291 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 196164003292 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 196164003293 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 196164003294 active site 196164003295 HIGH motif; other site 196164003296 KMSK motif region; other site 196164003297 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 196164003298 tRNA binding surface [nucleotide binding]; other site 196164003299 anticodon binding site; other site 196164003300 diaminopimelate decarboxylase; Region: lysA; TIGR01048 196164003301 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 196164003302 active site 196164003303 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196164003304 substrate binding site [chemical binding]; other site 196164003305 catalytic residues [active] 196164003306 dimer interface [polypeptide binding]; other site 196164003307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164003308 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164003309 DNA binding residues [nucleotide binding] 196164003310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196164003311 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 196164003312 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 196164003313 homoserine dehydrogenase; Provisional; Region: PRK06349 196164003314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003315 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 196164003316 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 196164003317 homoserine kinase; Provisional; Region: PRK01212 196164003318 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164003319 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164003320 Predicted transcriptional regulator [Transcription]; Region: COG2345 196164003321 Helix-turn-helix domains; Region: HTH; cl00088 196164003322 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 196164003323 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 196164003324 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 196164003325 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 196164003326 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 196164003327 [4Fe-4S] binding site [ion binding]; other site 196164003328 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196164003329 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196164003330 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 196164003331 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 196164003332 molybdopterin cofactor binding site; other site 196164003333 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 196164003334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003335 putative substrate translocation pore; other site 196164003336 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 196164003337 MPT binding site; other site 196164003338 trimer interface [polypeptide binding]; other site 196164003339 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 196164003340 GTP binding site; other site 196164003341 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 196164003342 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 196164003343 dimer interface [polypeptide binding]; other site 196164003344 putative functional site; other site 196164003345 putative MPT binding site; other site 196164003346 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 196164003347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164003348 FeS/SAM binding site; other site 196164003349 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 196164003350 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 196164003351 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164003352 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 196164003353 transcription termination factor Rho; Provisional; Region: PRK12608 196164003354 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 196164003355 RNA binding site [nucleotide binding]; other site 196164003356 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 196164003357 multimer interface [polypeptide binding]; other site 196164003358 Walker A motif; other site 196164003359 ATP binding site [chemical binding]; other site 196164003360 Walker B motif; other site 196164003361 peptide chain release factor 1; Validated; Region: prfA; PRK00591 196164003362 RF-1 domain; Region: RF-1; cl02875 196164003363 RF-1 domain; Region: RF-1; cl02875 196164003364 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 196164003365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164003366 S-adenosylmethionine binding site [chemical binding]; other site 196164003367 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 196164003368 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 196164003369 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 196164003370 Mg++ binding site [ion binding]; other site 196164003371 putative catalytic motif [active] 196164003372 substrate binding site [chemical binding]; other site 196164003373 ATP synthase A chain; Region: ATP-synt_A; cl00413 196164003374 ATP synthase subunit C; Region: ATP-synt_C; cl00466 196164003375 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 196164003376 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 196164003377 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 196164003378 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 196164003379 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 196164003380 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 196164003381 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 196164003382 beta subunit interaction interface [polypeptide binding]; other site 196164003383 Walker A motif; other site 196164003384 ATP binding site [chemical binding]; other site 196164003385 Walker B motif; other site 196164003386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 196164003387 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 196164003388 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 196164003389 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 196164003390 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 196164003391 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 196164003392 alpha subunit interaction interface [polypeptide binding]; other site 196164003393 Walker A motif; other site 196164003394 ATP binding site [chemical binding]; other site 196164003395 Walker B motif; other site 196164003396 inhibitor binding site; inhibition site 196164003397 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 196164003398 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 196164003399 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 196164003400 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 196164003401 Protein of unknown function DUF91; Region: DUF91; cl00709 196164003402 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 196164003403 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 196164003404 dimer interface [polypeptide binding]; other site 196164003405 substrate binding site [chemical binding]; other site 196164003406 metal binding site [ion binding]; metal-binding site 196164003407 Domain of unknown function DUF77; Region: DUF77; cl00307 196164003408 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 196164003409 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 196164003410 glycogen branching enzyme; Provisional; Region: PRK05402 196164003411 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 196164003412 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 196164003413 active site 196164003414 catalytic site [active] 196164003415 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 196164003416 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 196164003417 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 196164003418 active site 196164003419 catalytic site [active] 196164003420 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 196164003421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003422 Walker A/P-loop; other site 196164003423 ATP binding site [chemical binding]; other site 196164003424 Q-loop/lid; other site 196164003425 ABC transporter signature motif; other site 196164003426 Walker B; other site 196164003427 D-loop; other site 196164003428 H-loop/switch region; other site 196164003429 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 196164003430 Ligand binding site [chemical binding]; other site 196164003431 Electron transfer flavoprotein domain; Region: ETF; pfam01012 196164003432 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 196164003433 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 196164003434 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 196164003435 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 196164003436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 196164003437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196164003438 catalytic residue [active] 196164003439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164003440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003441 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 196164003442 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 196164003443 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196164003444 active site 196164003445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164003447 putative substrate translocation pore; other site 196164003448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003449 putative substrate translocation pore; other site 196164003450 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196164003451 active site 196164003452 substrate binding site [chemical binding]; other site 196164003453 catalytic site [active] 196164003454 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 196164003455 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 196164003456 nucleotide binding pocket [chemical binding]; other site 196164003457 K-X-D-G motif; other site 196164003458 catalytic site [active] 196164003459 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 196164003460 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 196164003461 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 196164003462 Dimer interface [polypeptide binding]; other site 196164003463 BRCT sequence motif; other site 196164003464 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 196164003465 Active site serine [active] 196164003466 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 196164003467 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 196164003468 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 196164003469 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 196164003470 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 196164003471 FAD binding pocket [chemical binding]; other site 196164003472 FAD binding motif [chemical binding]; other site 196164003473 phosphate binding motif [ion binding]; other site 196164003474 NAD binding pocket [chemical binding]; other site 196164003475 6-phosphofructokinase; Provisional; Region: PRK03202 196164003476 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 196164003477 active site 196164003478 ADP/pyrophosphate binding site [chemical binding]; other site 196164003479 dimerization interface [polypeptide binding]; other site 196164003480 allosteric effector site; other site 196164003481 fructose-1,6-bisphosphate binding site; other site 196164003482 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196164003483 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196164003484 DNA binding site [nucleotide binding] 196164003485 domain linker motif; other site 196164003486 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 196164003487 dimerization interface [polypeptide binding]; other site 196164003488 putative ligand binding site [chemical binding]; other site 196164003489 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164003490 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164003491 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 196164003492 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 196164003493 GatB domain; Region: GatB_Yqey; cl11497 196164003494 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 196164003495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196164003496 active site 196164003497 catalytic tetrad [active] 196164003498 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164003499 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 196164003500 Walker A/P-loop; other site 196164003501 ATP binding site [chemical binding]; other site 196164003502 Q-loop/lid; other site 196164003503 ABC transporter signature motif; other site 196164003504 Walker B; other site 196164003505 D-loop; other site 196164003506 H-loop/switch region; other site 196164003507 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196164003508 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 196164003509 Histidine kinase; Region: HisKA_3; pfam07730 196164003510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 196164003511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164003512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164003513 active site 196164003514 phosphorylation site [posttranslational modification] 196164003515 intermolecular recognition site; other site 196164003516 dimerization interface [polypeptide binding]; other site 196164003517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164003518 DNA binding residues [nucleotide binding] 196164003519 dimerization interface [polypeptide binding]; other site 196164003520 LysE type translocator; Region: LysE; cl00565 196164003521 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 196164003522 Helix-turn-helix domains; Region: HTH; cl00088 196164003523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164003524 dimerization interface [polypeptide binding]; other site 196164003525 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 196164003526 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196164003527 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 196164003528 putative dimer interface [polypeptide binding]; other site 196164003529 N-terminal domain interface [polypeptide binding]; other site 196164003530 putative substrate binding pocket (H-site) [chemical binding]; other site 196164003531 Domain of unknown function (DUF1994); Region: DUF1994; cl09179 196164003532 DoxX; Region: DoxX; cl00976 196164003533 Dehydratase family; Region: ILVD_EDD; cl00340 196164003534 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 196164003535 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 196164003536 Mechanosensitive ion channel; Region: MS_channel; pfam00924 196164003537 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 196164003538 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 196164003539 PYR/PP interface [polypeptide binding]; other site 196164003540 dimer interface [polypeptide binding]; other site 196164003541 TPP binding site [chemical binding]; other site 196164003542 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 196164003543 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 196164003544 TPP-binding site [chemical binding]; other site 196164003545 dimer interface [polypeptide binding]; other site 196164003546 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 196164003547 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 196164003548 putative valine binding site [chemical binding]; other site 196164003549 dimer interface [polypeptide binding]; other site 196164003550 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 196164003551 ketol-acid reductoisomerase; Provisional; Region: PRK05479 196164003552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003553 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 196164003554 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 196164003555 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 196164003556 Walker A/P-loop; other site 196164003557 ATP binding site [chemical binding]; other site 196164003558 Q-loop/lid; other site 196164003559 ABC transporter signature motif; other site 196164003560 Walker B; other site 196164003561 D-loop; other site 196164003562 H-loop/switch region; other site 196164003563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196164003564 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 196164003565 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 196164003566 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196164003567 Flavin Reductases; Region: FlaRed; cl00801 196164003568 Cation efflux family; Region: Cation_efflux; cl00316 196164003569 Protein of unknown function DUF262; Region: DUF262; cl14890 196164003570 Domain of unknown function (DUF1994); Region: DUF1994; cl09179 196164003571 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 196164003572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003573 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 196164003574 putative L-serine binding site [chemical binding]; other site 196164003575 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 196164003576 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 196164003577 tartrate dehydrogenase; Provisional; Region: PRK08194 196164003578 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 196164003579 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196164003580 ligand binding site [chemical binding]; other site 196164003581 flexible hinge region; other site 196164003582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 196164003583 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196164003584 metal binding triad; other site 196164003585 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 196164003586 active site 196164003587 substrate binding site [chemical binding]; other site 196164003588 catalytic site [active] 196164003589 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 196164003590 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 196164003591 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 196164003592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164003593 S-adenosylmethionine binding site [chemical binding]; other site 196164003594 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 196164003595 chorismate binding enzyme; Region: Chorismate_bind; cl10555 196164003596 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 196164003597 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 196164003598 active site 196164003599 HIGH motif; other site 196164003600 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 196164003601 active site 196164003602 KMSKS motif; other site 196164003603 Helix-turn-helix domains; Region: HTH; cl00088 196164003604 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 196164003605 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 196164003606 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 196164003607 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 196164003608 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164003609 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164003610 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164003611 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 196164003612 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 196164003613 putative hydrophobic ligand binding site [chemical binding]; other site 196164003614 Helix-turn-helix domains; Region: HTH; cl00088 196164003615 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164003616 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164003617 putative transposase OrfB; Reviewed; Region: PHA02517 196164003618 Integrase core domain; Region: rve; cl01316 196164003619 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 196164003620 ThiC family; Region: ThiC; cl08031 196164003621 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164003622 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164003623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164003624 non-specific DNA binding site [nucleotide binding]; other site 196164003625 salt bridge; other site 196164003626 sequence-specific DNA binding site [nucleotide binding]; other site 196164003627 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164003628 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164003629 MULE transposase domain; Region: MULE; pfam10551 196164003630 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 196164003631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 196164003632 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 196164003633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 196164003634 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 196164003635 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 196164003636 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 196164003637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003638 putative substrate translocation pore; other site 196164003639 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 196164003640 nucleoside/Zn binding site; other site 196164003641 dimer interface [polypeptide binding]; other site 196164003642 catalytic motif [active] 196164003643 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 196164003644 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196164003645 dimer interface [polypeptide binding]; other site 196164003646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164003647 catalytic residue [active] 196164003648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 196164003649 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 196164003650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 196164003651 dimer interface [polypeptide binding]; other site 196164003652 active site 196164003653 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196164003654 catalytic residues [active] 196164003655 substrate binding site [chemical binding]; other site 196164003656 AAA domain; Region: AAA_26; pfam13500 196164003657 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196164003659 inhibitor-cofactor binding pocket; inhibition site 196164003660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164003661 catalytic residue [active] 196164003662 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 196164003663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 196164003664 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 196164003665 Helix-turn-helix domains; Region: HTH; cl00088 196164003666 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196164003667 Bacterial transcriptional regulator; Region: IclR; pfam01614 196164003668 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 196164003669 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 196164003670 substrate binding site [chemical binding]; other site 196164003671 ligand binding site [chemical binding]; other site 196164003672 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 196164003673 substrate binding site [chemical binding]; other site 196164003674 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 196164003675 active site 196164003676 Ap6A binding site [chemical binding]; other site 196164003677 nudix motif; other site 196164003678 metal binding site [ion binding]; metal-binding site 196164003679 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 196164003680 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 196164003681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003682 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 196164003683 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 196164003684 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 196164003685 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164003686 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 196164003687 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164003688 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 196164003689 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 196164003690 thiamine monophosphate kinase; Provisional; Region: PRK05731 196164003691 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 196164003692 ATP binding site [chemical binding]; other site 196164003693 dimerization interface [polypeptide binding]; other site 196164003694 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 196164003695 ligand binding site [chemical binding]; other site 196164003696 active site 196164003697 UGI interface [polypeptide binding]; other site 196164003698 catalytic site [active] 196164003699 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 196164003700 DAK2 domain; Region: Dak2; cl03685 196164003701 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 196164003702 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 196164003703 generic binding surface II; other site 196164003704 ssDNA binding site; other site 196164003705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164003706 ATP binding site [chemical binding]; other site 196164003707 putative Mg++ binding site [ion binding]; other site 196164003708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164003709 nucleotide binding region [chemical binding]; other site 196164003710 ATP-binding site [chemical binding]; other site 196164003711 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 196164003712 lipoyl-biotinyl attachment site [posttranslational modification]; other site 196164003713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164003714 S-adenosylmethionine binding site [chemical binding]; other site 196164003715 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 196164003716 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 196164003717 active site 196164003718 (T/H)XGH motif; other site 196164003719 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 196164003720 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196164003721 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 196164003722 Walker A/P-loop; other site 196164003723 ATP binding site [chemical binding]; other site 196164003724 Q-loop/lid; other site 196164003725 ABC transporter signature motif; other site 196164003726 Walker B; other site 196164003727 D-loop; other site 196164003728 H-loop/switch region; other site 196164003729 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 196164003730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164003731 dimer interface [polypeptide binding]; other site 196164003732 conserved gate region; other site 196164003733 putative PBP binding loops; other site 196164003734 ABC-ATPase subunit interface; other site 196164003735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196164003736 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 196164003737 substrate binding pocket [chemical binding]; other site 196164003738 membrane-bound complex binding site; other site 196164003739 hinge residues; other site 196164003740 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 196164003741 AAA domain; Region: AAA_21; pfam13304 196164003742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164003743 Transposase domain (DUF772); Region: DUF772; cl15789 196164003744 Uncharacterized conserved protein [Function unknown]; Region: COG4938 196164003745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003746 Walker B; other site 196164003747 D-loop; other site 196164003748 H-loop/switch region; other site 196164003749 Domain of unknown function (DUF368); Region: DUF368; cl00893 196164003750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164003751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164003752 dimerization interface [polypeptide binding]; other site 196164003753 putative DNA binding site [nucleotide binding]; other site 196164003754 putative Zn2+ binding site [ion binding]; other site 196164003755 DNA polymerase I; Provisional; Region: PRK05755 196164003756 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 196164003757 active site 196164003758 metal binding site 1 [ion binding]; metal-binding site 196164003759 putative 5' ssDNA interaction site; other site 196164003760 metal binding site 3; metal-binding site 196164003761 metal binding site 2 [ion binding]; metal-binding site 196164003762 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 196164003763 putative DNA binding site [nucleotide binding]; other site 196164003764 putative metal binding site [ion binding]; other site 196164003765 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 196164003766 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 196164003767 active site 196164003768 DNA binding site [nucleotide binding] 196164003769 catalytic site [active] 196164003770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164003771 S-adenosylmethionine binding site [chemical binding]; other site 196164003772 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 196164003773 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 196164003774 RNA binding site [nucleotide binding]; other site 196164003775 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 196164003776 RNA binding site [nucleotide binding]; other site 196164003777 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 196164003778 RNA binding site [nucleotide binding]; other site 196164003779 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 196164003780 RNA binding site [nucleotide binding]; other site 196164003781 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 196164003782 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 196164003783 active site turn [active] 196164003784 phosphorylation site [posttranslational modification] 196164003785 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 196164003786 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 196164003787 HPr interaction site; other site 196164003788 glycerol kinase (GK) interaction site [polypeptide binding]; other site 196164003789 active site 196164003790 phosphorylation site [posttranslational modification] 196164003791 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 196164003792 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 196164003793 CoA-binding site [chemical binding]; other site 196164003794 ATP-binding [chemical binding]; other site 196164003795 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 196164003796 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 196164003797 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 196164003798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164003799 Walker A motif; other site 196164003800 ATP binding site [chemical binding]; other site 196164003801 Walker B motif; other site 196164003802 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164003803 MULE transposase domain; Region: MULE; pfam10551 196164003804 Helix-turn-helix domains; Region: HTH; cl00088 196164003805 putative transposase OrfB; Reviewed; Region: PHA02517 196164003806 Integrase core domain; Region: rve; cl01316 196164003807 Integrase core domain; Region: rve; cl01316 196164003808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164003809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164003810 active site 196164003811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164003812 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 196164003813 putative ADP-binding pocket [chemical binding]; other site 196164003814 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 196164003815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164003816 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 196164003817 heme-binding site [chemical binding]; other site 196164003818 YwiC-like protein; Region: YwiC; pfam14256 196164003819 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 196164003820 putative hydrophobic ligand binding site [chemical binding]; other site 196164003821 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 196164003822 dinuclear metal binding motif [ion binding]; other site 196164003823 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 196164003824 active site 196164003825 tetramer interface [polypeptide binding]; other site 196164003826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164003827 putative substrate translocation pore; other site 196164003828 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 196164003829 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 196164003830 substrate binding site [chemical binding]; other site 196164003831 dimer interface [polypeptide binding]; other site 196164003832 ATP binding site [chemical binding]; other site 196164003833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196164003834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196164003835 DNA binding site [nucleotide binding] 196164003836 domain linker motif; other site 196164003837 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 196164003838 dimerization interface [polypeptide binding]; other site 196164003839 putative ligand binding site [chemical binding]; other site 196164003840 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 196164003841 Predicted esterase [General function prediction only]; Region: COG0627 196164003842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164003843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164003844 non-specific DNA binding site [nucleotide binding]; other site 196164003845 salt bridge; other site 196164003846 sequence-specific DNA binding site [nucleotide binding]; other site 196164003847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164003848 BstXI restriction endonuclease; Region: RE_BstXI; pfam09552 196164003849 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164003850 MULE transposase domain; Region: MULE; pfam10551 196164003851 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164003852 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164003853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 196164003854 excinuclease ABC subunit B; Provisional; Region: PRK05298 196164003855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164003856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164003857 nucleotide binding region [chemical binding]; other site 196164003858 ATP-binding site [chemical binding]; other site 196164003859 Ultra-violet resistance protein B; Region: UvrB; pfam12344 196164003860 UvrB/uvrC motif; Region: UVR; pfam02151 196164003861 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196164003862 Ligand Binding Site [chemical binding]; other site 196164003863 Low molecular weight phosphatase family; Region: LMWPc; cl00105 196164003864 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 196164003865 active site 196164003866 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 196164003867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164003869 DoxX; Region: DoxX; cl00976 196164003870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164003871 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 196164003872 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 196164003873 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 196164003874 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 196164003875 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 196164003876 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 196164003877 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 196164003878 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 196164003879 ribosomal protein L20; Region: rpl20; CHL00068 196164003880 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 196164003881 23S rRNA binding site [nucleotide binding]; other site 196164003882 L21 binding site [polypeptide binding]; other site 196164003883 L13 binding site [polypeptide binding]; other site 196164003884 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 196164003885 dimerization interface [polypeptide binding]; other site 196164003886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164003887 dimer interface [polypeptide binding]; other site 196164003888 conserved gate region; other site 196164003889 putative PBP binding loops; other site 196164003890 ABC-ATPase subunit interface; other site 196164003891 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 196164003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164003893 dimer interface [polypeptide binding]; other site 196164003894 conserved gate region; other site 196164003895 putative PBP binding loops; other site 196164003896 ABC-ATPase subunit interface; other site 196164003897 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 196164003898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164003899 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 196164003900 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 196164003901 Walker A/P-loop; other site 196164003902 ATP binding site [chemical binding]; other site 196164003903 Q-loop/lid; other site 196164003904 ABC transporter signature motif; other site 196164003905 Walker B; other site 196164003906 D-loop; other site 196164003907 H-loop/switch region; other site 196164003908 TOBE domain; Region: TOBE_2; cl01440 196164003909 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 196164003910 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 196164003911 active site 196164003912 catalytic site [active] 196164003913 metal binding site [ion binding]; metal-binding site 196164003914 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196164003915 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 196164003916 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 196164003917 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 196164003918 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 196164003919 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 196164003920 dimer interface [polypeptide binding]; other site 196164003921 motif 1; other site 196164003922 active site 196164003923 motif 2; other site 196164003924 motif 3; other site 196164003925 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 196164003926 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 196164003927 putative tRNA-binding site [nucleotide binding]; other site 196164003928 B3/4 domain; Region: B3_4; cl11458 196164003929 tRNA synthetase B5 domain; Region: B5; cl08394 196164003930 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 196164003931 dimer interface [polypeptide binding]; other site 196164003932 motif 1; other site 196164003933 motif 3; other site 196164003934 motif 2; other site 196164003935 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 196164003936 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 196164003937 active site 196164003938 catalytic triad [active] 196164003939 oxyanion hole [active] 196164003940 Acyltransferase family; Region: Acyl_transf_3; pfam01757 196164003941 OpgC protein; Region: OpgC_C; cl00792 196164003942 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 196164003943 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 196164003944 ligand binding site [chemical binding]; other site 196164003945 flexible hinge region; other site 196164003946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 196164003947 putative switch regulator; other site 196164003948 non-specific DNA interactions [nucleotide binding]; other site 196164003949 DNA binding site [nucleotide binding] 196164003950 sequence specific DNA binding site [nucleotide binding]; other site 196164003951 putative cAMP binding site [chemical binding]; other site 196164003952 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 196164003953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003954 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 196164003955 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 196164003956 heterotetramer interface [polypeptide binding]; other site 196164003957 active site pocket [active] 196164003958 cleavage site 196164003959 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 196164003960 feedback inhibition sensing region; other site 196164003961 homohexameric interface [polypeptide binding]; other site 196164003962 nucleotide binding site [chemical binding]; other site 196164003963 N-acetyl-L-glutamate binding site [chemical binding]; other site 196164003964 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 196164003965 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196164003966 inhibitor-cofactor binding pocket; inhibition site 196164003967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164003968 catalytic residue [active] 196164003969 ornithine carbamoyltransferase; Provisional; Region: PRK00779 196164003970 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196164003971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003972 arginine repressor; Provisional; Region: PRK03341 196164003973 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 196164003974 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 196164003975 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 196164003976 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 196164003977 ANP binding site [chemical binding]; other site 196164003978 Substrate Binding Site II [chemical binding]; other site 196164003979 Substrate Binding Site I [chemical binding]; other site 196164003980 argininosuccinate lyase; Provisional; Region: PRK00855 196164003981 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 196164003982 active sites [active] 196164003983 tetramer interface [polypeptide binding]; other site 196164003984 Helix-turn-helix domains; Region: HTH; cl00088 196164003985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164003986 NAD(P) binding site [chemical binding]; other site 196164003987 active site 196164003988 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 196164003989 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196164003990 metal ion-dependent adhesion site (MIDAS); other site 196164003991 Trm112p-like protein; Region: Trm112p; cl01066 196164003992 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 196164003993 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 196164003994 active site 196164003995 HIGH motif; other site 196164003996 dimer interface [polypeptide binding]; other site 196164003997 KMSKS motif; other site 196164003998 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 196164003999 Domain of unknown function (DUF4324); Region: DUF4324; pfam14212 196164004000 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 196164004001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164004002 active site 196164004003 motif I; other site 196164004004 motif II; other site 196164004005 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164004006 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 196164004007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196164004008 RNA binding surface [nucleotide binding]; other site 196164004009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164004010 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 196164004011 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 196164004012 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 196164004013 Walker A/P-loop; other site 196164004014 ATP binding site [chemical binding]; other site 196164004015 Q-loop/lid; other site 196164004016 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 196164004017 ABC transporter signature motif; other site 196164004018 Walker B; other site 196164004019 D-loop; other site 196164004020 H-loop/switch region; other site 196164004021 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 196164004022 Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135 196164004023 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 196164004024 CTP synthetase; Validated; Region: pyrG; PRK05380 196164004025 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 196164004026 Catalytic site [active] 196164004027 active site 196164004028 UTP binding site [chemical binding]; other site 196164004029 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 196164004030 active site 196164004031 putative oxyanion hole; other site 196164004032 catalytic triad [active] 196164004033 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 196164004034 dimer interface [polypeptide binding]; other site 196164004035 ADP-ribose binding site [chemical binding]; other site 196164004036 active site 196164004037 nudix motif; other site 196164004038 metal binding site [ion binding]; metal-binding site 196164004039 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 196164004040 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 196164004041 Int/Topo IB signature motif; other site 196164004042 active site 196164004043 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 196164004044 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164004045 P-loop; other site 196164004046 Magnesium ion binding site [ion binding]; other site 196164004047 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164004048 Magnesium ion binding site [ion binding]; other site 196164004049 ScpA/B protein; Region: ScpA_ScpB; cl00598 196164004050 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 196164004051 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 196164004052 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 196164004053 active site residue [active] 196164004054 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 196164004055 active site residue [active] 196164004056 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 196164004057 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 196164004058 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196164004059 RNA binding surface [nucleotide binding]; other site 196164004060 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 196164004061 active site 196164004062 cytidylate kinase; Provisional; Region: cmk; PRK00023 196164004063 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 196164004064 CMP-binding site; other site 196164004065 The sites determining sugar specificity; other site 196164004066 GTP-binding protein Der; Reviewed; Region: PRK03003 196164004067 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 196164004068 G1 box; other site 196164004069 GTP/Mg2+ binding site [chemical binding]; other site 196164004070 Switch I region; other site 196164004071 G2 box; other site 196164004072 Switch II region; other site 196164004073 G3 box; other site 196164004074 G4 box; other site 196164004075 G5 box; other site 196164004076 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 196164004077 G1 box; other site 196164004078 GTP/Mg2+ binding site [chemical binding]; other site 196164004079 Switch I region; other site 196164004080 G2 box; other site 196164004081 G3 box; other site 196164004082 Switch II region; other site 196164004083 G4 box; other site 196164004084 G5 box; other site 196164004085 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 196164004086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164004087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164004088 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164004089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004090 Q-loop/lid; other site 196164004091 ABC transporter signature motif; other site 196164004092 Walker B; other site 196164004093 D-loop; other site 196164004094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164004095 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164004096 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004097 Walker A/P-loop; other site 196164004098 ATP binding site [chemical binding]; other site 196164004099 Q-loop/lid; other site 196164004100 ABC transporter signature motif; other site 196164004101 Walker B; other site 196164004102 D-loop; other site 196164004103 H-loop/switch region; other site 196164004104 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 196164004105 ZIP Zinc transporter; Region: Zip; pfam02535 196164004106 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164004107 Transposase domain (DUF772); Region: DUF772; cl15789 196164004108 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 196164004109 Sulfatase; Region: Sulfatase; cl10460 196164004110 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 196164004111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 196164004112 SEC-C motif; Region: SEC-C; pfam02810 196164004113 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 196164004114 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 196164004115 OsmC-like protein; Region: OsmC; cl00767 196164004116 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 196164004117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004118 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 196164004119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004120 nucleotide binding region [chemical binding]; other site 196164004121 ATP-binding site [chemical binding]; other site 196164004122 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 196164004123 phosphopeptide binding site; other site 196164004124 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 196164004125 DNA binding residues [nucleotide binding] 196164004126 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164004127 Bifunctional nuclease; Region: DNase-RNase; cl00553 196164004128 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 196164004129 DNA binding residues [nucleotide binding] 196164004130 putative dimer interface [polypeptide binding]; other site 196164004131 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 196164004132 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 196164004133 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 196164004134 NAD(P) binding site [chemical binding]; other site 196164004135 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 196164004136 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 196164004137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196164004138 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 196164004139 substrate binding pocket [chemical binding]; other site 196164004140 membrane-bound complex binding site; other site 196164004141 hinge residues; other site 196164004142 Transposase domain (DUF772); Region: DUF772; cl12084 196164004143 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164004144 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 196164004145 Domain of unknown function DUF21; Region: DUF21; pfam01595 196164004146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196164004147 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196164004148 Domain of unknown function DUF21; Region: DUF21; pfam01595 196164004149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196164004150 Transporter associated domain; Region: CorC_HlyC; cl08393 196164004151 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 196164004152 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 196164004153 ATP binding site [chemical binding]; other site 196164004154 Mg++ binding site [ion binding]; other site 196164004155 motif III; other site 196164004156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004157 nucleotide binding region [chemical binding]; other site 196164004158 ATP-binding site [chemical binding]; other site 196164004159 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196164004160 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 196164004161 tetramerization interface [polypeptide binding]; other site 196164004162 NAD(P) binding site [chemical binding]; other site 196164004163 catalytic residues [active] 196164004164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004165 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 196164004166 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 196164004167 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 196164004168 CoenzymeA binding site [chemical binding]; other site 196164004169 subunit interaction site [polypeptide binding]; other site 196164004170 PHB binding site; other site 196164004171 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 196164004172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164004173 S-adenosylmethionine binding site [chemical binding]; other site 196164004174 multifunctional thiamine-phosphate pyrophosphorylase/synthase/phosphomethylpyrimidine kinase; Provisional; Region: PRK09517 196164004175 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 196164004176 thiamine phosphate binding site [chemical binding]; other site 196164004177 active site 196164004178 pyrophosphate binding site [ion binding]; other site 196164004179 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 196164004180 dimer interface [polypeptide binding]; other site 196164004181 substrate binding site [chemical binding]; other site 196164004182 ATP binding site [chemical binding]; other site 196164004183 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 196164004184 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 196164004185 substrate binding site [chemical binding]; other site 196164004186 multimerization interface [polypeptide binding]; other site 196164004187 ATP binding site [chemical binding]; other site 196164004188 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 196164004189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004191 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 196164004192 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 196164004193 metabolite-proton symporter; Region: 2A0106; TIGR00883 196164004194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164004195 putative substrate translocation pore; other site 196164004196 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164004197 Predicted membrane protein [Function unknown]; Region: COG1971 196164004198 Domain of unknown function DUF; Region: DUF204; pfam02659 196164004199 Membrane transport protein; Region: Mem_trans; cl09117 196164004200 A new structural DNA glycosylase; Region: AlkD_like; cd06561 196164004201 active site 196164004202 YceI-like domain; Region: YceI; cl01001 196164004203 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 196164004204 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 196164004205 Ligand binding site; other site 196164004206 Putative Catalytic site; other site 196164004207 DXD motif; other site 196164004208 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 196164004209 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 196164004210 putative active site [active] 196164004211 catalytic triad [active] 196164004212 putative dimer interface [polypeptide binding]; other site 196164004213 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 196164004214 Secretory lipase; Region: LIP; pfam03583 196164004215 precorrin-3B synthase; Region: CobG; TIGR02435 196164004216 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196164004217 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196164004218 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 196164004219 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 196164004220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164004221 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196164004222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004223 NAD(P) binding site [chemical binding]; other site 196164004224 active site 196164004225 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 196164004226 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 196164004227 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 196164004228 active site 196164004229 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164004230 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 196164004231 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 196164004232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164004233 ATP binding site [chemical binding]; other site 196164004234 putative Mg++ binding site [ion binding]; other site 196164004235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004236 nucleotide binding region [chemical binding]; other site 196164004237 ATP-binding site [chemical binding]; other site 196164004238 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 196164004239 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 196164004240 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 196164004241 Predicted transcriptional regulator [Transcription]; Region: COG2378 196164004242 Predicted transcriptional regulator [Transcription]; Region: COG2378 196164004243 Pup-ligase protein; Region: Pup_ligase; cl15463 196164004244 Pup-like protein; Region: Pup; cl05289 196164004245 Pup-ligase protein; Region: Pup_ligase; cl15463 196164004246 proteasome ATPase; Region: pup_AAA; TIGR03689 196164004247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164004248 Walker A motif; other site 196164004249 ATP binding site [chemical binding]; other site 196164004250 Walker B motif; other site 196164004251 arginine finger; other site 196164004252 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 196164004253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164004254 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 196164004255 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 196164004256 active site 196164004257 metal binding site [ion binding]; metal-binding site 196164004258 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 196164004259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164004260 non-specific DNA binding site [nucleotide binding]; other site 196164004261 salt bridge; other site 196164004262 sequence-specific DNA binding site [nucleotide binding]; other site 196164004263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164004264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 196164004265 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196164004266 Helix-turn-helix domains; Region: HTH; cl00088 196164004267 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 196164004268 Aspartase; Region: Aspartase; cd01357 196164004269 active sites [active] 196164004270 tetramer interface [polypeptide binding]; other site 196164004271 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 196164004272 ATP phosphoribosyltransferase; Region: HisG; cl15266 196164004273 HisG, C-terminal domain; Region: HisG_C; cl06867 196164004274 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 196164004275 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 196164004276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164004277 motif II; other site 196164004278 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 196164004279 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 196164004280 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 196164004281 substrate binding pocket [chemical binding]; other site 196164004282 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 196164004283 B12 binding site [chemical binding]; other site 196164004284 cobalt ligand [ion binding]; other site 196164004285 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 196164004286 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 196164004287 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164004288 active site 196164004289 HIGH motif; other site 196164004290 nucleotide binding site [chemical binding]; other site 196164004291 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164004292 active site 196164004293 KMSKS motif; other site 196164004294 Bacitracin resistance protein BacA; Region: BacA; cl00858 196164004295 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 196164004296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196164004297 active site 196164004298 catalytic tetrad [active] 196164004299 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 196164004300 quinone interaction residues [chemical binding]; other site 196164004301 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 196164004302 active site 196164004303 catalytic residues [active] 196164004304 FMN binding site [chemical binding]; other site 196164004305 substrate binding site [chemical binding]; other site 196164004306 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 196164004307 substrate binding site [chemical binding]; other site 196164004308 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164004309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004310 Walker A/P-loop; other site 196164004311 ATP binding site [chemical binding]; other site 196164004312 Q-loop/lid; other site 196164004313 ABC transporter signature motif; other site 196164004314 Walker B; other site 196164004315 D-loop; other site 196164004316 H-loop/switch region; other site 196164004317 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164004318 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164004319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004320 Q-loop/lid; other site 196164004321 ABC transporter signature motif; other site 196164004322 Walker B; other site 196164004323 D-loop; other site 196164004324 H-loop/switch region; other site 196164004325 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164004326 membrane ATPase/protein kinase; Provisional; Region: PRK09435 196164004327 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 196164004328 Walker A; other site 196164004329 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 196164004330 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 196164004331 active site 196164004332 substrate binding site [chemical binding]; other site 196164004333 coenzyme B12 binding site [chemical binding]; other site 196164004334 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 196164004335 B12 binding site [chemical binding]; other site 196164004336 cobalt ligand [ion binding]; other site 196164004337 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 196164004338 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 196164004339 heterodimer interface [polypeptide binding]; other site 196164004340 substrate interaction site [chemical binding]; other site 196164004341 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 196164004342 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 196164004343 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 196164004344 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 196164004345 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 196164004346 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 196164004347 ferrochelatase; Reviewed; Region: hemH; PRK00035 196164004348 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 196164004349 C-terminal domain interface [polypeptide binding]; other site 196164004350 active site 196164004351 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 196164004352 active site 196164004353 N-terminal domain interface [polypeptide binding]; other site 196164004354 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 196164004355 NlpC/P60 family; Region: NLPC_P60; cl11438 196164004356 aconitate hydratase; Validated; Region: PRK09277 196164004357 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 196164004358 substrate binding site [chemical binding]; other site 196164004359 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 196164004360 ligand binding site [chemical binding]; other site 196164004361 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 196164004362 substrate binding site [chemical binding]; other site 196164004363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164004364 Helix-turn-helix domains; Region: HTH; cl00088 196164004365 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 196164004366 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 196164004367 catalytic triad [active] 196164004368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164004369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004370 NAD(P) binding site [chemical binding]; other site 196164004371 active site 196164004372 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 196164004373 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 196164004374 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 196164004375 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 196164004376 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164004377 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164004378 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 196164004379 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 196164004380 CsbD-like; Region: CsbD; cl01888 196164004381 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 196164004382 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 196164004383 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164004384 Helix-turn-helix domains; Region: HTH; cl00088 196164004385 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196164004386 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164004387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004388 Walker A/P-loop; other site 196164004389 ATP binding site [chemical binding]; other site 196164004390 Q-loop/lid; other site 196164004391 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164004392 ABC transporter signature motif; other site 196164004393 Walker B; other site 196164004394 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164004395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004396 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 196164004397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004398 Domain of unknown function DUF59; Region: DUF59; cl00941 196164004399 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 196164004400 trimerization site [polypeptide binding]; other site 196164004401 active site 196164004402 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 196164004403 Aminotransferase class-V; Region: Aminotran_5; pfam00266 196164004404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 196164004405 catalytic residue [active] 196164004406 FeS assembly ATPase SufC; Region: sufC; TIGR01978 196164004407 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 196164004408 Walker A/P-loop; other site 196164004409 ATP binding site [chemical binding]; other site 196164004410 Q-loop/lid; other site 196164004411 ABC transporter signature motif; other site 196164004412 Walker B; other site 196164004413 D-loop; other site 196164004414 H-loop/switch region; other site 196164004415 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 196164004416 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 196164004417 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 196164004418 FeS assembly protein SufB; Region: sufB; TIGR01980 196164004419 Predicted transcriptional regulator [Transcription]; Region: COG2345 196164004420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164004421 putative DNA binding site [nucleotide binding]; other site 196164004422 putative Zn2+ binding site [ion binding]; other site 196164004423 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 196164004424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164004425 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 196164004426 Walker A/P-loop; other site 196164004427 ATP binding site [chemical binding]; other site 196164004428 Q-loop/lid; other site 196164004429 ABC transporter signature motif; other site 196164004430 Walker B; other site 196164004431 D-loop; other site 196164004432 H-loop/switch region; other site 196164004433 ABC-2 type transporter; Region: ABC2_membrane; cl11417 196164004434 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 196164004435 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 196164004436 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 196164004437 NADP binding site [chemical binding]; other site 196164004438 dimer interface [polypeptide binding]; other site 196164004439 UbiA prenyltransferase family; Region: UbiA; cl00337 196164004440 transketolase; Reviewed; Region: PRK05899 196164004441 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 196164004442 TPP-binding site [chemical binding]; other site 196164004443 dimer interface [polypeptide binding]; other site 196164004444 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 196164004445 PYR/PP interface [polypeptide binding]; other site 196164004446 dimer interface [polypeptide binding]; other site 196164004447 TPP binding site [chemical binding]; other site 196164004448 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196164004449 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 196164004450 putative active site [active] 196164004451 transaldolase; Provisional; Region: PRK03903 196164004452 catalytic residue [active] 196164004453 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 196164004454 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 196164004455 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 196164004456 opcA protein; Region: OpcA; TIGR00534 196164004457 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 196164004458 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 196164004459 putative active site [active] 196164004460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004461 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 196164004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004463 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 196164004464 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 196164004465 Preprotein translocase SecG subunit; Region: SecG; cl09123 196164004466 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 196164004467 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 196164004468 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 196164004469 substrate binding site [chemical binding]; other site 196164004470 dimer interface [polypeptide binding]; other site 196164004471 catalytic triad [active] 196164004472 Phosphoglycerate kinase; Region: PGK; pfam00162 196164004473 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 196164004474 substrate binding site [chemical binding]; other site 196164004475 hinge regions; other site 196164004476 ADP binding site [chemical binding]; other site 196164004477 catalytic site [active] 196164004478 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 196164004479 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 196164004480 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 196164004481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 196164004482 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 196164004483 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 196164004484 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 196164004485 phosphate binding site [ion binding]; other site 196164004486 putative substrate binding pocket [chemical binding]; other site 196164004487 dimer interface [polypeptide binding]; other site 196164004488 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 196164004489 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004490 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 196164004491 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 196164004492 GIY-YIG motif/motif A; other site 196164004493 active site 196164004494 catalytic site [active] 196164004495 putative DNA binding site [nucleotide binding]; other site 196164004496 metal binding site [ion binding]; metal-binding site 196164004497 UvrB/uvrC motif; Region: UVR; pfam02151 196164004498 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 196164004499 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 196164004500 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 196164004501 homopentamer interface [polypeptide binding]; other site 196164004502 active site 196164004503 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 196164004504 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 196164004505 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 196164004506 dimerization interface [polypeptide binding]; other site 196164004507 active site 196164004508 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 196164004509 Lumazine binding domain; Region: Lum_binding; pfam00677 196164004510 Lumazine binding domain; Region: Lum_binding; pfam00677 196164004511 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 196164004512 catalytic motif [active] 196164004513 Zn binding site [ion binding]; other site 196164004514 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 196164004515 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 196164004516 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 196164004517 substrate binding site [chemical binding]; other site 196164004518 hexamer interface [polypeptide binding]; other site 196164004519 metal binding site [ion binding]; metal-binding site 196164004520 16S rRNA methyltransferase B; Provisional; Region: PRK14902 196164004521 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 196164004522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164004523 S-adenosylmethionine binding site [chemical binding]; other site 196164004524 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 196164004525 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 196164004526 putative active site [active] 196164004527 substrate binding site [chemical binding]; other site 196164004528 putative cosubstrate binding site; other site 196164004529 catalytic site [active] 196164004530 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 196164004531 substrate binding site [chemical binding]; other site 196164004532 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 196164004533 active site 196164004534 catalytic residues [active] 196164004535 metal binding site [ion binding]; metal-binding site 196164004536 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196164004537 active site 196164004538 primosome assembly protein PriA; Provisional; Region: PRK14873 196164004539 S-adenosylmethionine synthetase; Validated; Region: PRK05250 196164004540 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 196164004541 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 196164004542 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 196164004543 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 196164004544 Flavoprotein; Region: Flavoprotein; cl08021 196164004545 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 196164004546 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 196164004547 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 196164004548 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 196164004549 catalytic site [active] 196164004550 G-X2-G-X-G-K; other site 196164004551 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 196164004552 active site 196164004553 dimer interface [polypeptide binding]; other site 196164004554 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 196164004555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196164004556 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164004557 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 196164004558 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164004559 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 196164004560 IMP binding site; other site 196164004561 dimer interface [polypeptide binding]; other site 196164004562 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 196164004563 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 196164004564 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 196164004565 catalytic site [active] 196164004566 subunit interface [polypeptide binding]; other site 196164004567 dihydroorotase; Validated; Region: pyrC; PRK09357 196164004568 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196164004569 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 196164004570 active site 196164004571 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 196164004572 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 196164004573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004574 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164004575 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 196164004576 putative hydrophobic ligand binding site [chemical binding]; other site 196164004577 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 196164004578 TIGR01777 family protein; Region: yfcH 196164004579 putative NAD(P) binding site [chemical binding]; other site 196164004580 putative active site [active] 196164004581 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 196164004582 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 196164004583 putative RNA binding site [nucleotide binding]; other site 196164004584 elongation factor P; Validated; Region: PRK00529 196164004585 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 196164004586 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 196164004587 RNA binding site [nucleotide binding]; other site 196164004588 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 196164004589 RNA binding site [nucleotide binding]; other site 196164004590 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 196164004591 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 196164004592 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 196164004593 active site 196164004594 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 196164004595 trimer interface [polypeptide binding]; other site 196164004596 active site 196164004597 dimer interface [polypeptide binding]; other site 196164004598 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 196164004599 active site 196164004600 dimer interface [polypeptide binding]; other site 196164004601 metal binding site [ion binding]; metal-binding site 196164004602 shikimate kinase; Reviewed; Region: aroK; PRK00131 196164004603 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 196164004604 ADP binding site [chemical binding]; other site 196164004605 magnesium binding site [ion binding]; other site 196164004606 putative shikimate binding site; other site 196164004607 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 196164004608 Tetramer interface [polypeptide binding]; other site 196164004609 active site 196164004610 FMN-binding site [chemical binding]; other site 196164004611 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 196164004612 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 196164004613 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 196164004614 shikimate binding site; other site 196164004615 NAD(P) binding site [chemical binding]; other site 196164004616 YceG-like family; Region: YceG; pfam02618 196164004617 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 196164004618 dimerization interface [polypeptide binding]; other site 196164004619 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 196164004620 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 196164004621 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 196164004622 motif 1; other site 196164004623 active site 196164004624 motif 2; other site 196164004625 motif 3; other site 196164004626 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 196164004627 DHHA1 domain; Region: DHHA1; pfam02272 196164004628 recombination factor protein RarA; Reviewed; Region: PRK13342 196164004629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164004630 Walker A motif; other site 196164004631 ATP binding site [chemical binding]; other site 196164004632 Walker B motif; other site 196164004633 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 196164004634 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 196164004635 substrate binding site [chemical binding]; other site 196164004636 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 196164004637 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 196164004638 dimer interface [polypeptide binding]; other site 196164004639 anticodon binding site; other site 196164004640 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 196164004641 homodimer interface [polypeptide binding]; other site 196164004642 motif 1; other site 196164004643 active site 196164004644 motif 2; other site 196164004645 GAD domain; Region: GAD; pfam02938 196164004646 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 196164004647 active site 196164004648 motif 3; other site 196164004649 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 196164004650 DEAD-like helicases superfamily; Region: DEXDc; smart00487 196164004651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164004652 ATP binding site [chemical binding]; other site 196164004653 putative Mg++ binding site [ion binding]; other site 196164004654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004655 nucleotide binding region [chemical binding]; other site 196164004656 ATP-binding site [chemical binding]; other site 196164004657 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 196164004658 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 196164004659 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 196164004660 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 196164004661 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164004662 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 196164004663 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164004664 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164004665 MULE transposase domain; Region: MULE; pfam10551 196164004666 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164004667 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 196164004668 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 196164004669 dimer interface [polypeptide binding]; other site 196164004670 motif 1; other site 196164004671 active site 196164004672 motif 2; other site 196164004673 motif 3; other site 196164004674 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 196164004675 anticodon binding site; other site 196164004676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164004677 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 196164004678 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 196164004679 active site 196164004680 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 196164004681 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196164004682 Zn2+ binding site [ion binding]; other site 196164004683 Mg2+ binding site [ion binding]; other site 196164004684 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196164004685 synthetase active site [active] 196164004686 NTP binding site [chemical binding]; other site 196164004687 metal binding site [ion binding]; metal-binding site 196164004688 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 196164004689 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 196164004690 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164004691 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196164004692 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 196164004693 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 196164004694 Protein export membrane protein; Region: SecD_SecF; cl14618 196164004695 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 196164004696 Protein export membrane protein; Region: SecD_SecF; cl14618 196164004697 Preprotein translocase subunit; Region: YajC; cl00806 196164004698 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 196164004699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164004700 Walker A motif; other site 196164004701 ATP binding site [chemical binding]; other site 196164004702 Walker B motif; other site 196164004703 arginine finger; other site 196164004704 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 196164004705 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 196164004706 RuvA N terminal domain; Region: RuvA_N; pfam01330 196164004707 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 196164004708 active site 196164004709 putative DNA-binding cleft [nucleotide binding]; other site 196164004710 dimer interface [polypeptide binding]; other site 196164004711 Domain of unknown function DUF28; Region: DUF28; cl00361 196164004712 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 196164004713 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 196164004714 active site 196164004715 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 196164004716 catalytic triad [active] 196164004717 dimer interface [polypeptide binding]; other site 196164004718 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 196164004719 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 196164004720 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 196164004721 active site 196164004722 multimer interface [polypeptide binding]; other site 196164004723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164004724 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196164004725 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 196164004726 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164004727 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 196164004728 putative acyl-acceptor binding pocket; other site 196164004729 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 196164004730 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 196164004731 nucleotide binding site/active site [active] 196164004732 HIT family signature motif; other site 196164004733 catalytic residue [active] 196164004734 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 196164004735 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 196164004736 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 196164004737 active site 196164004738 dimer interface [polypeptide binding]; other site 196164004739 motif 1; other site 196164004740 motif 2; other site 196164004741 motif 3; other site 196164004742 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 196164004743 anticodon binding site; other site 196164004744 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 196164004745 Protein of unknown function (DUF461); Region: DUF461; cl01071 196164004746 Bacterial Ig-like domain; Region: Big_5; cl01012 196164004747 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 196164004748 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196164004749 SelR domain; Region: SelR; cl00369 196164004750 Chlorite dismutase; Region: Chlor_dismutase; cl01280 196164004751 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 196164004752 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 196164004753 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 196164004754 putative active site [active] 196164004755 catalytic site [active] 196164004756 putative substrate binding site [chemical binding]; other site 196164004757 HRDC domain; Region: HRDC; cl02578 196164004758 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 196164004759 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 196164004760 TPP-binding site; other site 196164004761 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 196164004762 PYR/PP interface [polypeptide binding]; other site 196164004763 dimer interface [polypeptide binding]; other site 196164004764 TPP binding site [chemical binding]; other site 196164004765 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 196164004766 TRAM domain; Region: TRAM; cl01282 196164004767 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 196164004768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164004769 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 196164004770 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 196164004771 trimer interface [polypeptide binding]; other site 196164004772 active site 196164004773 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 196164004774 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 196164004775 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 196164004776 active site 196164004777 dimerization interface [polypeptide binding]; other site 196164004778 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 196164004779 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 196164004780 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 196164004781 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 196164004782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164004783 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 196164004784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164004785 DNA binding residues [nucleotide binding] 196164004786 Predicted membrane protein [Function unknown]; Region: COG2311 196164004787 Protein of unknown function (DUF418); Region: DUF418; cl12135 196164004788 Protein of unknown function (DUF418); Region: DUF418; cl12135 196164004789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164004790 ATP binding site [chemical binding]; other site 196164004791 putative Mg++ binding site [ion binding]; other site 196164004792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004793 nucleotide binding region [chemical binding]; other site 196164004794 ATP-binding site [chemical binding]; other site 196164004795 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 196164004796 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 196164004797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164004798 S-adenosylmethionine binding site [chemical binding]; other site 196164004799 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 196164004800 putative active site [active] 196164004801 dimerization interface [polypeptide binding]; other site 196164004802 putative tRNAtyr binding site [nucleotide binding]; other site 196164004803 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 196164004804 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 196164004805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164004806 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 196164004807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164004808 DNA binding residues [nucleotide binding] 196164004809 Helix-turn-helix domains; Region: HTH; cl00088 196164004810 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 196164004811 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 196164004812 FeoA domain; Region: FeoA; cl00838 196164004813 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 196164004814 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 196164004815 NAD binding site [chemical binding]; other site 196164004816 homodimer interface [polypeptide binding]; other site 196164004817 active site 196164004818 substrate binding site [chemical binding]; other site 196164004819 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 196164004820 PAC2 family; Region: PAC2; cl00847 196164004821 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164004822 ATP binding site [chemical binding]; other site 196164004823 putative Mg++ binding site [ion binding]; other site 196164004824 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004825 nucleotide binding region [chemical binding]; other site 196164004826 ATP-binding site [chemical binding]; other site 196164004827 primosome assembly protein PriA; Validated; Region: PRK05580 196164004828 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 196164004829 Helix-turn-helix domains; Region: HTH; cl00088 196164004830 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 196164004831 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 196164004832 dimerization interface [polypeptide binding]; other site 196164004833 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 196164004834 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 196164004835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164004836 ATP binding site [chemical binding]; other site 196164004837 putative Mg++ binding site [ion binding]; other site 196164004838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164004839 nucleotide binding region [chemical binding]; other site 196164004840 ATP-binding site [chemical binding]; other site 196164004841 Helicase associated domain (HA2); Region: HA2; cl04503 196164004842 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 196164004843 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 196164004844 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 196164004845 ATP cone domain; Region: ATP-cone; pfam03477 196164004846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164004847 LexA repressor; Validated; Region: PRK00215 196164004848 Helix-turn-helix domains; Region: HTH; cl00088 196164004849 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 196164004850 Catalytic site [active] 196164004851 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196164004852 Helix-turn-helix domains; Region: HTH; cl00088 196164004853 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164004854 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 196164004855 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 196164004856 putative substrate binding site [chemical binding]; other site 196164004857 putative ATP binding site [chemical binding]; other site 196164004858 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 196164004859 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 196164004860 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 196164004861 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 196164004862 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196164004863 Helix-turn-helix domains; Region: HTH; cl00088 196164004864 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164004865 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 196164004866 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 196164004867 putative substrate binding site [chemical binding]; other site 196164004868 putative ATP binding site [chemical binding]; other site 196164004869 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 196164004870 active site 196164004871 phosphorylation site [posttranslational modification] 196164004872 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 196164004873 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 196164004874 P-loop; other site 196164004875 active site 196164004876 phosphorylation site [posttranslational modification] 196164004877 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 196164004878 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 196164004879 dimerization domain swap beta strand [polypeptide binding]; other site 196164004880 regulatory protein interface [polypeptide binding]; other site 196164004881 active site 196164004882 regulatory phosphorylation site [posttranslational modification]; other site 196164004883 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 196164004884 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 196164004885 uracil transporter; Provisional; Region: PRK10720 196164004886 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 196164004887 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 196164004888 G1 box; other site 196164004889 GTP/Mg2+ binding site [chemical binding]; other site 196164004890 Switch I region; other site 196164004891 G2 box; other site 196164004892 G3 box; other site 196164004893 Switch II region; other site 196164004894 G4 box; other site 196164004895 G5 box; other site 196164004896 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 196164004897 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 196164004898 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 196164004899 IPP transferase; Region: IPPT; cl00403 196164004900 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 196164004901 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 196164004902 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 196164004903 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 196164004904 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 196164004905 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 196164004906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164004907 FeS/SAM binding site; other site 196164004908 TRAM domain; Region: TRAM; cl01282 196164004909 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 196164004910 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 196164004911 Walker A/P-loop; other site 196164004912 ATP binding site [chemical binding]; other site 196164004913 Q-loop/lid; other site 196164004914 ABC transporter signature motif; other site 196164004915 Walker B; other site 196164004916 D-loop; other site 196164004917 H-loop/switch region; other site 196164004918 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 196164004919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196164004920 substrate binding pocket [chemical binding]; other site 196164004921 membrane-bound complex binding site; other site 196164004922 hinge residues; other site 196164004923 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 196164004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164004925 dimer interface [polypeptide binding]; other site 196164004926 conserved gate region; other site 196164004927 putative PBP binding loops; other site 196164004928 ABC-ATPase subunit interface; other site 196164004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164004930 dimer interface [polypeptide binding]; other site 196164004931 conserved gate region; other site 196164004932 putative PBP binding loops; other site 196164004933 ABC-ATPase subunit interface; other site 196164004934 RecX family; Region: RecX; cl00936 196164004935 recombinase A; Provisional; Region: recA; PRK09354 196164004936 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 196164004937 hexamer interface [polypeptide binding]; other site 196164004938 Walker A motif; other site 196164004939 ATP binding site [chemical binding]; other site 196164004940 Walker B motif; other site 196164004941 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 196164004942 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 196164004943 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 196164004944 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 196164004945 Walker A/P-loop; other site 196164004946 ATP binding site [chemical binding]; other site 196164004947 Q-loop/lid; other site 196164004948 ABC transporter signature motif; other site 196164004949 Walker B; other site 196164004950 D-loop; other site 196164004951 H-loop/switch region; other site 196164004952 Cobalt transport protein; Region: CbiQ; cl00463 196164004953 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 196164004954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164004955 non-specific DNA binding site [nucleotide binding]; other site 196164004956 salt bridge; other site 196164004957 sequence-specific DNA binding site [nucleotide binding]; other site 196164004958 Competence-damaged protein; Region: CinA; cl00666 196164004959 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 196164004960 YCII-related domain; Region: YCII; cl00999 196164004961 Integral membrane protein TerC family; Region: TerC; cl10468 196164004962 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 196164004963 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164004964 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 196164004965 TIGR03085 family protein; Region: TIGR03085 196164004966 DinB superfamily; Region: DinB_2; cl00986 196164004967 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 196164004968 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164004969 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 196164004970 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 196164004971 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 196164004972 dimer interface [polypeptide binding]; other site 196164004973 active site 196164004974 catalytic residue [active] 196164004975 Thymidylate synthase complementing protein; Region: Thy1; cl03630 196164004976 dihydrodipicolinate reductase; Provisional; Region: PRK00048 196164004977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164004978 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 196164004979 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 196164004980 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 196164004981 oligomer interface [polypeptide binding]; other site 196164004982 RNA binding site [nucleotide binding]; other site 196164004983 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 196164004984 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 196164004985 RNase E interface [polypeptide binding]; other site 196164004986 trimer interface [polypeptide binding]; other site 196164004987 active site 196164004988 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 196164004989 putative nucleic acid binding region [nucleotide binding]; other site 196164004990 G-X-X-G motif; other site 196164004991 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 196164004992 RNA binding site [nucleotide binding]; other site 196164004993 domain interface; other site 196164004994 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 196164004995 16S/18S rRNA binding site [nucleotide binding]; other site 196164004996 S13e-L30e interaction site [polypeptide binding]; other site 196164004997 25S rRNA binding site [nucleotide binding]; other site 196164004998 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 196164004999 active site 196164005000 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 196164005001 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 196164005002 active site 196164005003 Riboflavin kinase; Region: Flavokinase; cl03312 196164005004 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 196164005005 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 196164005006 RNA binding site [nucleotide binding]; other site 196164005007 active site 196164005008 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 196164005009 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 196164005010 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196164005011 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 196164005012 active site 196164005013 metal binding site [ion binding]; metal-binding site 196164005014 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 196164005015 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 196164005016 MatE; Region: MatE; cl10513 196164005017 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 196164005018 DHH family; Region: DHH; pfam01368 196164005019 Ribosome-binding factor A; Region: RBFA; cl00542 196164005020 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196164005021 translation initiation factor IF-2; Region: IF-2; TIGR00487 196164005022 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196164005023 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 196164005024 G1 box; other site 196164005025 putative GEF interaction site [polypeptide binding]; other site 196164005026 GTP/Mg2+ binding site [chemical binding]; other site 196164005027 Switch I region; other site 196164005028 G2 box; other site 196164005029 G3 box; other site 196164005030 Switch II region; other site 196164005031 G4 box; other site 196164005032 G5 box; other site 196164005033 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 196164005034 Translation-initiation factor 2; Region: IF-2; pfam11987 196164005035 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 196164005036 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 196164005037 putative RNA binding cleft [nucleotide binding]; other site 196164005038 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 196164005039 NusA N-terminal domain; Region: NusA_N; pfam08529 196164005040 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 196164005041 RNA binding site [nucleotide binding]; other site 196164005042 homodimer interface [polypeptide binding]; other site 196164005043 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 196164005044 G-X-X-G motif; other site 196164005045 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 196164005046 G-X-X-G motif; other site 196164005047 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 196164005048 ribosome maturation protein RimP; Reviewed; Region: PRK00092 196164005049 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 196164005050 dinuclear metal binding motif [ion binding]; other site 196164005051 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 196164005052 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 196164005053 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196164005054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164005055 dimer interface [polypeptide binding]; other site 196164005056 conserved gate region; other site 196164005057 ABC-ATPase subunit interface; other site 196164005058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196164005059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164005060 dimer interface [polypeptide binding]; other site 196164005061 conserved gate region; other site 196164005062 putative PBP binding loops; other site 196164005063 ABC-ATPase subunit interface; other site 196164005064 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196164005065 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 196164005066 Walker A/P-loop; other site 196164005067 ATP binding site [chemical binding]; other site 196164005068 Q-loop/lid; other site 196164005069 ABC transporter signature motif; other site 196164005070 Walker B; other site 196164005071 D-loop; other site 196164005072 H-loop/switch region; other site 196164005073 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196164005074 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 196164005075 Walker A/P-loop; other site 196164005076 ATP binding site [chemical binding]; other site 196164005077 Q-loop/lid; other site 196164005078 ABC transporter signature motif; other site 196164005079 Walker B; other site 196164005080 D-loop; other site 196164005081 H-loop/switch region; other site 196164005082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196164005083 prolyl-tRNA synthetase; Provisional; Region: PRK09194 196164005084 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 196164005085 dimer interface [polypeptide binding]; other site 196164005086 motif 1; other site 196164005087 active site 196164005088 motif 2; other site 196164005089 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 196164005090 putative deacylase active site [active] 196164005091 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 196164005092 active site 196164005093 motif 3; other site 196164005094 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 196164005095 anticodon binding site; other site 196164005096 Protein of unknown function (DUF328); Region: DUF328; cl01143 196164005097 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 196164005098 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 196164005099 metal ion-dependent adhesion site (MIDAS); other site 196164005100 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 196164005101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164005102 Walker A motif; other site 196164005103 ATP binding site [chemical binding]; other site 196164005104 Walker B motif; other site 196164005105 arginine finger; other site 196164005106 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 196164005107 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 196164005108 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 196164005109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005110 Predicted dehydrogenase [General function prediction only]; Region: COG0579 196164005111 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 196164005112 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164005113 mycothione reductase; Reviewed; Region: PRK07846 196164005114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005115 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 196164005116 cobyric acid synthase; Provisional; Region: PRK00784 196164005117 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005118 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005119 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 196164005120 catalytic triad [active] 196164005121 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 196164005122 active site 196164005123 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 196164005124 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196164005125 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164005126 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 196164005127 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 196164005128 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 196164005129 active site 196164005130 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 196164005131 protein binding site [polypeptide binding]; other site 196164005132 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 196164005133 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 196164005134 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 196164005135 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 196164005136 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 196164005137 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 196164005138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164005139 FeS/SAM binding site; other site 196164005140 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 196164005141 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 196164005142 ribosome recycling factor; Reviewed; Region: frr; PRK00083 196164005143 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 196164005144 hinge region; other site 196164005145 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 196164005146 putative nucleotide binding site [chemical binding]; other site 196164005147 uridine monophosphate binding site [chemical binding]; other site 196164005148 homohexameric interface [polypeptide binding]; other site 196164005149 elongation factor Ts; Provisional; Region: tsf; PRK09377 196164005150 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 196164005151 Elongation factor TS; Region: EF_TS; pfam00889 196164005152 Elongation factor TS; Region: EF_TS; pfam00889 196164005153 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 196164005154 rRNA interaction site [nucleotide binding]; other site 196164005155 S8 interaction site; other site 196164005156 putative laminin-1 binding site; other site 196164005157 Peptidase family M23; Region: Peptidase_M23; pfam01551 196164005158 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 196164005159 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 196164005160 DNA binding site [nucleotide binding] 196164005161 Int/Topo IB signature motif; other site 196164005162 active site 196164005163 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 196164005164 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 196164005165 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 196164005166 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 196164005167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005168 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 196164005169 Excalibur calcium-binding domain; Region: Excalibur; cl05460 196164005170 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164005171 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164005172 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 196164005173 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 196164005174 RNA/DNA hybrid binding site [nucleotide binding]; other site 196164005175 active site 196164005176 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 196164005177 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 196164005178 Catalytic site [active] 196164005179 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 196164005180 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164005181 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164005182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005183 Walker A/P-loop; other site 196164005184 ATP binding site [chemical binding]; other site 196164005185 Q-loop/lid; other site 196164005186 ABC transporter signature motif; other site 196164005187 Walker B; other site 196164005188 D-loop; other site 196164005189 H-loop/switch region; other site 196164005190 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005191 active site 196164005192 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196164005193 Domain of unknown function DUF21; Region: DUF21; pfam01595 196164005194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196164005195 Transporter associated domain; Region: CorC_HlyC; cl08393 196164005196 Domain of unknown function DUF21; Region: DUF21; pfam01595 196164005197 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196164005198 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164005199 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 196164005200 protein binding site [polypeptide binding]; other site 196164005201 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 196164005202 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 196164005203 active site 196164005204 pyrophosphate binding site [ion binding]; other site 196164005205 thiamine phosphate binding site [chemical binding]; other site 196164005206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005207 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196164005208 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 196164005209 thiS-thiF/thiG interaction site; other site 196164005210 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 196164005211 ThiS interaction site; other site 196164005212 putative active site [active] 196164005213 tetramer interface [polypeptide binding]; other site 196164005214 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 196164005215 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 196164005216 ATP binding site [chemical binding]; other site 196164005217 substrate interface [chemical binding]; other site 196164005218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 196164005219 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 196164005220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164005221 FeS/SAM binding site; other site 196164005222 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 196164005223 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 196164005224 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 196164005225 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 196164005226 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 196164005227 RNA binding site [nucleotide binding]; other site 196164005228 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 196164005229 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 196164005230 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164005231 Predicted membrane protein [Function unknown]; Region: COG4129 196164005232 putative transposase OrfB; Reviewed; Region: PHA02517 196164005233 Transposase; Region: DEDD_Tnp_IS110; pfam01548 196164005234 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 196164005235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164005236 non-specific DNA binding site [nucleotide binding]; other site 196164005237 salt bridge; other site 196164005238 sequence-specific DNA binding site [nucleotide binding]; other site 196164005239 putative transposase OrfB; Reviewed; Region: PHA02517 196164005240 Integrase core domain; Region: rve; cl01316 196164005241 Helix-turn-helix domains; Region: HTH; cl00088 196164005242 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164005243 MULE transposase domain; Region: MULE; pfam10551 196164005244 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164005245 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 196164005246 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 196164005247 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 196164005248 RimM N-terminal domain; Region: RimM; pfam01782 196164005249 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 196164005250 Cupin domain; Region: Cupin_2; cl09118 196164005251 Cupin domain; Region: Cupin_2; cl09118 196164005252 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 196164005253 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196164005254 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196164005255 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164005256 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005257 Walker A/P-loop; other site 196164005258 ATP binding site [chemical binding]; other site 196164005259 Q-loop/lid; other site 196164005260 ABC transporter signature motif; other site 196164005261 Walker B; other site 196164005262 D-loop; other site 196164005263 H-loop/switch region; other site 196164005264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164005265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164005266 putative substrate translocation pore; other site 196164005267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164005268 putative substrate translocation pore; other site 196164005269 signal recognition particle protein; Provisional; Region: PRK10867 196164005270 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 196164005271 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 196164005272 P loop; other site 196164005273 GTP binding site [chemical binding]; other site 196164005274 Signal peptide binding domain; Region: SRP_SPB; pfam02978 196164005275 PII uridylyl-transferase; Provisional; Region: glnD; PRK00227 196164005276 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196164005277 metal binding triad; other site 196164005278 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 196164005279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 196164005280 Nitrogen regulatory protein P-II; Region: P-II; cl00412 196164005281 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 196164005282 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 196164005283 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 196164005284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005285 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 196164005286 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 196164005287 Walker A/P-loop; other site 196164005288 ATP binding site [chemical binding]; other site 196164005289 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 196164005290 ABC transporter signature motif; other site 196164005291 Walker B; other site 196164005292 D-loop; other site 196164005293 H-loop/switch region; other site 196164005294 Acylphosphatase; Region: Acylphosphatase; cl00551 196164005295 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 196164005296 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 196164005297 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 196164005298 DNA binding site [nucleotide binding] 196164005299 catalytic residue [active] 196164005300 H2TH interface [polypeptide binding]; other site 196164005301 putative catalytic residues [active] 196164005302 turnover-facilitating residue; other site 196164005303 intercalation triad [nucleotide binding]; other site 196164005304 8OG recognition residue [nucleotide binding]; other site 196164005305 putative reading head residues; other site 196164005306 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196164005307 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196164005308 ribonuclease III; Reviewed; Region: rnc; PRK00102 196164005309 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 196164005310 dimerization interface [polypeptide binding]; other site 196164005311 active site 196164005312 metal binding site [ion binding]; metal-binding site 196164005313 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 196164005314 dsRNA binding site [nucleotide binding]; other site 196164005315 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 196164005316 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 196164005317 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 196164005318 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 196164005319 Walker A/P-loop; other site 196164005320 ATP binding site [chemical binding]; other site 196164005321 Q-loop/lid; other site 196164005322 ABC transporter signature motif; other site 196164005323 Walker B; other site 196164005324 D-loop; other site 196164005325 H-loop/switch region; other site 196164005326 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164005327 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 196164005328 Walker A/P-loop; other site 196164005329 ATP binding site [chemical binding]; other site 196164005330 Q-loop/lid; other site 196164005331 ABC transporter signature motif; other site 196164005332 Walker B; other site 196164005333 D-loop; other site 196164005334 H-loop/switch region; other site 196164005335 glutamate dehydrogenase; Provisional; Region: PRK09414 196164005336 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 196164005337 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 196164005338 NAD(P) binding site [chemical binding]; other site 196164005339 Glycerate kinase family; Region: Gly_kinase; cl00841 196164005340 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 196164005341 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 196164005342 nucleotide binding site/active site [active] 196164005343 HIT family signature motif; other site 196164005344 catalytic residue [active] 196164005345 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196164005346 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 196164005347 metal binding site [ion binding]; metal-binding site 196164005348 putative dimer interface [polypeptide binding]; other site 196164005349 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 196164005350 putative homodimer interface [polypeptide binding]; other site 196164005351 putative active site pocket [active] 196164005352 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 196164005353 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 196164005354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 196164005355 putative metal binding site [ion binding]; other site 196164005356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 196164005357 active site 196164005358 metal binding site [ion binding]; metal-binding site 196164005359 pyruvate kinase; Provisional; Region: PRK06247 196164005360 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 196164005361 domain interfaces; other site 196164005362 active site 196164005363 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 196164005364 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 196164005365 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 196164005366 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 196164005367 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 196164005368 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 196164005369 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 196164005370 substrate binding site [chemical binding]; other site 196164005371 glutamase interaction surface [polypeptide binding]; other site 196164005372 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 196164005373 active site 196164005374 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 196164005375 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 196164005376 catalytic residues [active] 196164005377 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 196164005378 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 196164005379 putative active site [active] 196164005380 oxyanion strand; other site 196164005381 catalytic triad [active] 196164005382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164005383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164005384 putative substrate translocation pore; other site 196164005385 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 196164005386 putative active site pocket [active] 196164005387 4-fold oligomerization interface [polypeptide binding]; other site 196164005388 metal binding residues [ion binding]; metal-binding site 196164005389 3-fold/trimer interface [polypeptide binding]; other site 196164005390 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 196164005391 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164005392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164005393 homodimer interface [polypeptide binding]; other site 196164005394 catalytic residue [active] 196164005395 histidinol dehydrogenase; Region: hisD; TIGR00069 196164005396 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 196164005397 NAD binding site [chemical binding]; other site 196164005398 dimerization interface [polypeptide binding]; other site 196164005399 product binding site; other site 196164005400 substrate binding site [chemical binding]; other site 196164005401 zinc binding site [ion binding]; other site 196164005402 catalytic residues [active] 196164005403 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 196164005404 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 196164005405 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 196164005406 DNA binding residues [nucleotide binding] 196164005407 dimer interface [polypeptide binding]; other site 196164005408 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 196164005409 tetracycline repressor protein TetR; Provisional; Region: PRK13756 196164005410 Helix-turn-helix domains; Region: HTH; cl00088 196164005411 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 196164005412 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 196164005413 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 196164005414 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 196164005415 active site 196164005416 catalytic site [active] 196164005417 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196164005418 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196164005419 Walker A/P-loop; other site 196164005420 ATP binding site [chemical binding]; other site 196164005421 Q-loop/lid; other site 196164005422 ABC transporter signature motif; other site 196164005423 Walker B; other site 196164005424 D-loop; other site 196164005425 H-loop/switch region; other site 196164005426 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 196164005427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164005428 ABC-ATPase subunit interface; other site 196164005429 dimer interface [polypeptide binding]; other site 196164005430 putative PBP binding regions; other site 196164005431 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 196164005432 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 196164005433 putative binding site residues; other site 196164005434 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164005435 dimerization interface [polypeptide binding]; other site 196164005436 putative DNA binding site [nucleotide binding]; other site 196164005437 putative Zn2+ binding site [ion binding]; other site 196164005438 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 196164005439 active site 196164005440 substrate binding site [chemical binding]; other site 196164005441 catalytic site [active] 196164005442 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 196164005443 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 196164005444 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 196164005445 active site 196164005446 catalytic site [active] 196164005447 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 196164005448 synthetase active site [active] 196164005449 NTP binding site [chemical binding]; other site 196164005450 metal binding site [ion binding]; metal-binding site 196164005451 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164005452 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 196164005453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196164005454 RNA binding surface [nucleotide binding]; other site 196164005455 Uncharacterized conserved protein [Function unknown]; Region: COG1739 196164005456 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 196164005457 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 196164005458 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 196164005459 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 196164005460 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 196164005461 catalytic site [active] 196164005462 active site 196164005463 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 196164005464 threonine dehydratase; Validated; Region: PRK08639 196164005465 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 196164005466 tetramer interface [polypeptide binding]; other site 196164005467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164005468 catalytic residue [active] 196164005469 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 196164005470 putative Ile/Val binding site [chemical binding]; other site 196164005471 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 196164005472 substrate binding site [chemical binding]; other site 196164005473 THF binding site; other site 196164005474 zinc-binding site [ion binding]; other site 196164005475 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 196164005476 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 196164005477 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 196164005478 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 196164005479 generic binding surface II; other site 196164005480 generic binding surface I; other site 196164005481 rarD protein; Region: rarD; TIGR00688 196164005482 EamA-like transporter family; Region: EamA; cl01037 196164005483 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 196164005484 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 196164005485 RNA binding surface [nucleotide binding]; other site 196164005486 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 196164005487 active site 196164005488 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 196164005489 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 196164005490 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005491 Walker A/P-loop; other site 196164005492 ATP binding site [chemical binding]; other site 196164005493 Q-loop/lid; other site 196164005494 ABC transporter signature motif; other site 196164005495 Walker B; other site 196164005496 D-loop; other site 196164005497 H-loop/switch region; other site 196164005498 ABC transporter; Region: ABC_tran_2; pfam12848 196164005499 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164005500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164005501 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 196164005502 Walker A/P-loop; other site 196164005503 ATP binding site [chemical binding]; other site 196164005504 Q-loop/lid; other site 196164005505 ABC transporter signature motif; other site 196164005506 Walker B; other site 196164005507 D-loop; other site 196164005508 H-loop/switch region; other site 196164005509 ABC-2 type transporter; Region: ABC2_membrane; cl11417 196164005510 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 196164005511 active site 196164005512 homotetramer interface [polypeptide binding]; other site 196164005513 homodimer interface [polypeptide binding]; other site 196164005514 DNA polymerase IV; Provisional; Region: PRK03348 196164005515 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 196164005516 active site 196164005517 DNA binding site [nucleotide binding] 196164005518 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 196164005519 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 196164005520 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 196164005521 HIGH motif; other site 196164005522 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 196164005523 active site 196164005524 KMSKS motif; other site 196164005525 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 196164005526 tRNA binding surface [nucleotide binding]; other site 196164005527 anticodon binding site; other site 196164005528 DivIVA domain; Region: DivI1A_domain; TIGR03544 196164005529 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 196164005530 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 196164005531 Protein of unknown function (DUF552); Region: DUF552; cl00775 196164005532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 196164005533 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 196164005534 catalytic residue [active] 196164005535 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 196164005536 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 196164005537 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 196164005538 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 196164005539 nucleotide binding site [chemical binding]; other site 196164005540 SulA interaction site; other site 196164005541 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 196164005542 Cell division protein FtsQ; Region: FtsQ; pfam03799 196164005543 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 196164005544 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196164005545 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 196164005546 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196164005547 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 196164005548 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 196164005549 active site 196164005550 homodimer interface [polypeptide binding]; other site 196164005551 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 196164005552 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 196164005553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 196164005555 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196164005556 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 196164005557 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 196164005558 Mg++ binding site [ion binding]; other site 196164005559 putative catalytic motif [active] 196164005560 putative substrate binding site [chemical binding]; other site 196164005561 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 196164005562 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196164005563 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 196164005564 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196164005565 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 196164005566 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 196164005567 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 196164005568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 196164005569 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 196164005570 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 196164005571 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164005572 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 196164005573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164005574 cell division protein MraZ; Reviewed; Region: PRK00326 196164005575 MraZ protein; Region: MraZ; pfam02381 196164005576 MraZ protein; Region: MraZ; pfam02381 196164005577 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 196164005578 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164005579 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 196164005580 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 196164005581 FAD binding site [chemical binding]; other site 196164005582 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 196164005583 substrate binding pocket [chemical binding]; other site 196164005584 chain length determination region; other site 196164005585 substrate-Mg2+ binding site; other site 196164005586 catalytic residues [active] 196164005587 aspartate-rich region 1; other site 196164005588 active site lid residues [active] 196164005589 aspartate-rich region 2; other site 196164005590 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 196164005591 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164005592 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 196164005593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 196164005594 active site 196164005595 ATP binding site [chemical binding]; other site 196164005596 substrate binding site [chemical binding]; other site 196164005597 activation loop (A-loop); other site 196164005598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 196164005599 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 196164005600 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196164005601 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196164005602 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 196164005603 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196164005604 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196164005605 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 196164005606 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196164005607 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196164005608 OpgC protein; Region: OpgC_C; cl00792 196164005609 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 196164005610 putative acyl-acceptor binding pocket; other site 196164005611 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 196164005612 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 196164005613 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164005614 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196164005615 NlpC/P60 family; Region: NLPC_P60; cl11438 196164005616 NlpC/P60 family; Region: NLPC_P60; cl11438 196164005617 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 196164005618 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 196164005619 heme bH binding site [chemical binding]; other site 196164005620 intrachain domain interface; other site 196164005621 heme bL binding site [chemical binding]; other site 196164005622 interchain domain interface [polypeptide binding]; other site 196164005623 Qo binding site; other site 196164005624 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 196164005625 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 196164005626 iron-sulfur cluster [ion binding]; other site 196164005627 [2Fe-2S] cluster binding site [ion binding]; other site 196164005628 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 196164005629 Cytochrome c; Region: Cytochrom_C; cl11414 196164005630 Cytochrome c; Region: Cytochrom_C; cl11414 196164005631 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 196164005632 Subunit I/III interface [polypeptide binding]; other site 196164005633 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 196164005634 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 196164005635 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 196164005636 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 196164005637 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 196164005638 active site 196164005639 dimer interface [polypeptide binding]; other site 196164005640 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 196164005641 Ligand Binding Site [chemical binding]; other site 196164005642 Molecular Tunnel; other site 196164005643 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 196164005644 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 196164005645 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 196164005646 homotrimer interface [polypeptide binding]; other site 196164005647 Walker A motif; other site 196164005648 GTP binding site [chemical binding]; other site 196164005649 Walker B motif; other site 196164005650 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 196164005651 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 196164005652 putative dimer interface [polypeptide binding]; other site 196164005653 active site pocket [active] 196164005654 putative cataytic base [active] 196164005655 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 196164005656 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 196164005657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005658 NAD(P) binding site [chemical binding]; other site 196164005659 active site 196164005660 Branched-chain amino acid aminotransferase; Region: DUF3665; pfam12427 196164005661 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 196164005662 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 196164005663 homodimer interface [polypeptide binding]; other site 196164005664 substrate-cofactor binding pocket; other site 196164005665 catalytic residue [active] 196164005666 multifunctional aminopeptidase A; Provisional; Region: PRK00913 196164005667 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 196164005668 interface (dimer of trimers) [polypeptide binding]; other site 196164005669 Substrate-binding/catalytic site; other site 196164005670 Zn-binding sites [ion binding]; other site 196164005671 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 196164005672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196164005673 E3 interaction surface; other site 196164005674 lipoyl attachment site [posttranslational modification]; other site 196164005675 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 196164005676 E3 interaction surface; other site 196164005677 lipoyl attachment site [posttranslational modification]; other site 196164005678 e3 binding domain; Region: E3_binding; pfam02817 196164005679 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 196164005680 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 196164005681 lipoyl synthase; Provisional; Region: PRK05481 196164005682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164005683 FeS/SAM binding site; other site 196164005684 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 196164005685 Predicted permease [General function prediction only]; Region: COG2985 196164005686 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 196164005687 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 196164005688 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 196164005689 RDD family; Region: RDD; cl00746 196164005690 glutamine synthetase, type I; Region: GlnA; TIGR00653 196164005691 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 196164005692 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 196164005693 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 196164005694 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 196164005695 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 196164005696 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 196164005697 active site 196164005698 oxyanion hole [active] 196164005699 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 196164005700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196164005701 catalytic loop [active] 196164005702 iron binding site [ion binding]; other site 196164005703 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 196164005704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164005705 Walker A motif; other site 196164005706 ATP binding site [chemical binding]; other site 196164005707 Walker B motif; other site 196164005708 Integrase core domain; Region: rve; cl01316 196164005709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005710 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 196164005711 glutamine synthetase, type I; Region: GlnA; TIGR00653 196164005712 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 196164005713 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 196164005714 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 196164005715 nudix motif; other site 196164005716 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 196164005717 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164005718 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 196164005719 EamA-like transporter family; Region: EamA; cl01037 196164005720 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 196164005721 EamA-like transporter family; Region: EamA; cl01037 196164005722 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 196164005723 homotrimer interaction site [polypeptide binding]; other site 196164005724 putative active site [active] 196164005725 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 196164005726 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 196164005727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164005728 catalytic residue [active] 196164005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164005730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164005731 putative substrate translocation pore; other site 196164005732 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 196164005733 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196164005734 metal binding triad; other site 196164005735 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 196164005736 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 196164005737 metal binding triad; other site 196164005738 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 196164005739 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 196164005740 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 196164005741 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 196164005742 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 196164005743 putative active site; other site 196164005744 putative metal binding residues [ion binding]; other site 196164005745 signature motif; other site 196164005746 putative triphosphate binding site [ion binding]; other site 196164005747 CHAD domain; Region: CHAD; cl10506 196164005748 CHAD domain; Region: CHAD; cl10506 196164005749 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 196164005750 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 196164005751 RNB domain; Region: RNB; pfam00773 196164005752 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 196164005753 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 196164005754 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 196164005755 RNA/DNA hybrid binding site [nucleotide binding]; other site 196164005756 active site 196164005757 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164005758 catalytic core [active] 196164005759 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 196164005760 Putative zinc ribbon domain; Region: DUF164; pfam02591 196164005761 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 196164005762 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 196164005763 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 196164005764 hypothetical protein; Provisional; Region: PRK07908 196164005765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164005766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164005767 homodimer interface [polypeptide binding]; other site 196164005768 catalytic residue [active] 196164005769 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 196164005770 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164005771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164005772 motif II; other site 196164005773 Low molecular weight phosphatase family; Region: LMWPc; cd00115 196164005774 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 196164005775 active site 196164005776 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 196164005777 CobD/Cbib protein; Region: CobD_Cbib; cl00561 196164005778 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 196164005779 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 196164005780 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 196164005781 dimer interface [polypeptide binding]; other site 196164005782 TPP-binding site [chemical binding]; other site 196164005783 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 196164005784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005785 Walker A/P-loop; other site 196164005786 ATP binding site [chemical binding]; other site 196164005787 Q-loop/lid; other site 196164005788 ABC transporter signature motif; other site 196164005789 Walker B; other site 196164005790 D-loop; other site 196164005791 H-loop/switch region; other site 196164005792 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 196164005793 TM-ABC transporter signature motif; other site 196164005794 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 196164005795 zinc binding site [ion binding]; other site 196164005796 putative ligand binding site [chemical binding]; other site 196164005797 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196164005798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196164005799 Phosphopantetheine attachment site; Region: PP-binding; cl09936 196164005800 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 196164005801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164005802 active site 196164005803 motif I; other site 196164005804 motif II; other site 196164005805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164005806 Uncharacterized conserved protein [Function unknown]; Region: COG4850 196164005807 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 196164005808 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164005809 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 196164005810 polymerase nucleotide-binding site; other site 196164005811 DNA-binding residues [nucleotide binding]; DNA binding site 196164005812 nucleotide binding site [chemical binding]; other site 196164005813 primase nucleotide-binding site [nucleotide binding]; other site 196164005814 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 196164005815 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164005816 Phage integrase family; Region: Phage_integrase; pfam00589 196164005817 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 196164005818 DNA binding site [nucleotide binding] 196164005819 Int/Topo IB signature motif; other site 196164005820 active site 196164005821 catalytic residues [active] 196164005822 PhoD-like phosphatase; Region: PhoD; pfam09423 196164005823 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 196164005824 putative active site [active] 196164005825 putative metal binding site [ion binding]; other site 196164005826 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 196164005827 OsmC-like protein; Region: OsmC; cl00767 196164005828 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 196164005829 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 196164005830 DNA primase; Validated; Region: dnaG; PRK05667 196164005831 CHC2 zinc finger; Region: zf-CHC2; cl15369 196164005832 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 196164005833 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 196164005834 active site 196164005835 metal binding site [ion binding]; metal-binding site 196164005836 interdomain interaction site; other site 196164005837 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 196164005838 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 196164005839 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 196164005840 active site 196164005841 barstar interaction site; other site 196164005842 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 196164005843 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 196164005844 glutaminase active site [active] 196164005845 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 196164005846 dimer interface [polypeptide binding]; other site 196164005847 active site 196164005848 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 196164005849 dimer interface [polypeptide binding]; other site 196164005850 active site 196164005851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196164005852 Zn2+ binding site [ion binding]; other site 196164005853 Mg2+ binding site [ion binding]; other site 196164005854 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 196164005855 putative active site [active] 196164005856 TIGR02680 family protein; Region: TIGR02680 196164005857 glycyl-tRNA synthetase; Provisional; Region: PRK04173 196164005858 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 196164005859 motif 1; other site 196164005860 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 196164005861 active site 196164005862 motif 2; other site 196164005863 motif 3; other site 196164005864 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 196164005865 anticodon binding site; other site 196164005866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164005867 dimerization interface [polypeptide binding]; other site 196164005868 putative DNA binding site [nucleotide binding]; other site 196164005869 putative Zn2+ binding site [ion binding]; other site 196164005870 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 196164005871 metal binding site 2 [ion binding]; metal-binding site 196164005872 putative DNA binding helix; other site 196164005873 metal binding site 1 [ion binding]; metal-binding site 196164005874 dimer interface [polypeptide binding]; other site 196164005875 structural Zn2+ binding site [ion binding]; other site 196164005876 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 196164005877 diiron binding motif [ion binding]; other site 196164005878 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 196164005879 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 196164005880 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 196164005881 catalytic residue [active] 196164005882 putative FPP diphosphate binding site; other site 196164005883 putative FPP binding hydrophobic cleft; other site 196164005884 dimer interface [polypeptide binding]; other site 196164005885 putative IPP diphosphate binding site; other site 196164005886 Recombination protein O N terminal; Region: RecO_N; pfam11967 196164005887 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 196164005888 Recombination protein O C terminal; Region: RecO_C; pfam02565 196164005889 GTPase Era; Reviewed; Region: era; PRK00089 196164005890 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 196164005891 G1 box; other site 196164005892 GTP/Mg2+ binding site [chemical binding]; other site 196164005893 Switch I region; other site 196164005894 G2 box; other site 196164005895 Switch II region; other site 196164005896 G3 box; other site 196164005897 G4 box; other site 196164005898 G5 box; other site 196164005899 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 196164005900 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 196164005901 Domain of unknown function DUF21; Region: DUF21; pfam01595 196164005902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 196164005903 Transporter associated domain; Region: CorC_HlyC; cl08393 196164005904 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 196164005905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164005906 RNA methyltransferase, RsmE family; Region: TIGR00046 196164005907 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 196164005908 chaperone protein DnaJ; Provisional; Region: PRK14278 196164005909 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 196164005910 HSP70 interaction site [polypeptide binding]; other site 196164005911 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 196164005912 Zn binding sites [ion binding]; other site 196164005913 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 196164005914 dimer interface [polypeptide binding]; other site 196164005915 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 196164005916 Helix-turn-helix domains; Region: HTH; cl00088 196164005917 HrcA protein C terminal domain; Region: HrcA; pfam01628 196164005918 coproporphyrinogen III oxidase; Validated; Region: PRK05628 196164005919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164005920 FeS/SAM binding site; other site 196164005921 HemN C-terminal domain; Region: HemN_C; pfam06969 196164005922 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 196164005923 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164005924 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 196164005925 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 196164005926 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 196164005927 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 196164005928 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 196164005929 Walker A/P-loop; other site 196164005930 ATP binding site [chemical binding]; other site 196164005931 Q-loop/lid; other site 196164005932 ABC transporter signature motif; other site 196164005933 Walker B; other site 196164005934 D-loop; other site 196164005935 H-loop/switch region; other site 196164005936 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 196164005937 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 196164005938 CHY zinc finger; Region: zf-CHY; pfam05495 196164005939 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 196164005940 Permease family; Region: Xan_ur_permease; cl00967 196164005941 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 196164005942 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164005943 DNA binding residues [nucleotide binding] 196164005944 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 196164005945 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 196164005946 active site 196164005947 Zn binding site [ion binding]; other site 196164005948 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 196164005949 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164005950 substrate binding pocket [chemical binding]; other site 196164005951 catalytic triad [active] 196164005952 trehalose synthase; Region: treS_nterm; TIGR02456 196164005953 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 196164005954 active site 196164005955 catalytic site [active] 196164005956 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 196164005957 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 196164005958 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 196164005959 active site 196164005960 metal binding site [ion binding]; metal-binding site 196164005961 nudix motif; other site 196164005962 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 196164005963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164005964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164005965 homodimer interface [polypeptide binding]; other site 196164005966 catalytic residue [active] 196164005967 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 196164005968 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164005969 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 196164005970 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 196164005971 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 196164005972 BCCT family transporter; Region: BCCT; cl00569 196164005973 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 196164005974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 196164005975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005976 FAD binding domain; Region: FAD_binding_3; pfam01494 196164005977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164005979 Membrane transport protein; Region: Mem_trans; cl09117 196164005980 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 196164005981 FAD binding domain; Region: FAD_binding_4; pfam01565 196164005982 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 196164005983 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 196164005984 Transcriptional regulators [Transcription]; Region: GntR; COG1802 196164005985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164005986 DNA-binding site [nucleotide binding]; DNA binding site 196164005987 FCD domain; Region: FCD; cl11656 196164005988 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 196164005989 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 196164005990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196164005991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164005992 dimer interface [polypeptide binding]; other site 196164005993 conserved gate region; other site 196164005994 putative PBP binding loops; other site 196164005995 ABC-ATPase subunit interface; other site 196164005996 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 196164005997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164005998 dimer interface [polypeptide binding]; other site 196164005999 conserved gate region; other site 196164006000 putative PBP binding loops; other site 196164006001 ABC-ATPase subunit interface; other site 196164006002 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196164006003 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 196164006004 Walker A/P-loop; other site 196164006005 ATP binding site [chemical binding]; other site 196164006006 Q-loop/lid; other site 196164006007 ABC transporter signature motif; other site 196164006008 Walker B; other site 196164006009 D-loop; other site 196164006010 H-loop/switch region; other site 196164006011 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196164006012 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 196164006013 Walker A/P-loop; other site 196164006014 ATP binding site [chemical binding]; other site 196164006015 Q-loop/lid; other site 196164006016 ABC transporter signature motif; other site 196164006017 Walker B; other site 196164006018 D-loop; other site 196164006019 H-loop/switch region; other site 196164006020 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196164006021 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 196164006022 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 196164006023 Membrane transport protein; Region: Mem_trans; cl09117 196164006024 bile acid transporter; Region: bass; TIGR00841 196164006025 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 196164006026 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 196164006027 active site 196164006028 phosphate binding residues; other site 196164006029 catalytic residues [active] 196164006030 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 196164006031 active site 196164006032 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 196164006033 tetramer interface [polypeptide binding]; other site 196164006034 active site 196164006035 Mg2+/Mn2+ binding site [ion binding]; other site 196164006036 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 196164006037 putative active site [active] 196164006038 putative metal binding site [ion binding]; other site 196164006039 Intermediate filament tail domain; Region: IF_tail; pfam00932 196164006040 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196164006041 DctM-like transporters; Region: DctM; pfam06808 196164006042 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 196164006043 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 196164006044 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 196164006045 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 196164006046 GTP-binding protein LepA; Provisional; Region: PRK05433 196164006047 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 196164006048 G1 box; other site 196164006049 putative GEF interaction site [polypeptide binding]; other site 196164006050 GTP/Mg2+ binding site [chemical binding]; other site 196164006051 Switch I region; other site 196164006052 G2 box; other site 196164006053 G3 box; other site 196164006054 Switch II region; other site 196164006055 G4 box; other site 196164006056 G5 box; other site 196164006057 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 196164006058 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 196164006059 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 196164006060 PemK-like protein; Region: PemK; cl00995 196164006061 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 196164006062 LysE type translocator; Region: LysE; cl00565 196164006063 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 196164006064 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 196164006065 hypothetical protein; Validated; Region: PRK05629 196164006066 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 196164006067 Competence protein; Region: Competence; cl00471 196164006068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 196164006069 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 196164006070 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 196164006071 P-class dimer interface [polypeptide binding]; other site 196164006072 active site 196164006073 Cu2+ binding site [ion binding]; other site 196164006074 E-class dimer interface [polypeptide binding]; other site 196164006075 Zn2+ binding site [ion binding]; other site 196164006076 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164006077 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164006078 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 196164006079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164006080 catalytic core [active] 196164006081 Domain of unknown function DUF143; Region: DUF143; cl00519 196164006082 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 196164006083 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 196164006084 active site 196164006085 (T/H)XGH motif; other site 196164006086 Cutinase; Region: Cutinase; cl15711 196164006087 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 196164006088 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 196164006089 putative catalytic cysteine [active] 196164006090 Predicted membrane protein [Function unknown]; Region: COG4325 196164006091 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 196164006092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006093 gamma-glutamyl kinase; Provisional; Region: PRK05429 196164006094 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 196164006095 nucleotide binding site [chemical binding]; other site 196164006096 homotetrameric interface [polypeptide binding]; other site 196164006097 putative phosphate binding site [ion binding]; other site 196164006098 putative allosteric binding site; other site 196164006099 PUA domain; Region: PUA; cl00607 196164006100 GTPase CgtA; Reviewed; Region: obgE; PRK12296 196164006101 GTP1/OBG; Region: GTP1_OBG; pfam01018 196164006102 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 196164006103 G1 box; other site 196164006104 GTP/Mg2+ binding site [chemical binding]; other site 196164006105 Switch I region; other site 196164006106 G2 box; other site 196164006107 G3 box; other site 196164006108 Switch II region; other site 196164006109 G4 box; other site 196164006110 G5 box; other site 196164006111 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 196164006112 Permease family; Region: Xan_ur_permease; cl00967 196164006113 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 196164006114 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 196164006115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 196164006116 active site 196164006117 catalytic tetrad [active] 196164006118 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 196164006119 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 196164006120 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 196164006121 translation initiation factor IF-2; Validated; Region: infB; PRK05306 196164006122 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 196164006123 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 196164006124 homodimer interface [polypeptide binding]; other site 196164006125 oligonucleotide binding site [chemical binding]; other site 196164006126 Pirin-related protein [General function prediction only]; Region: COG1741 196164006127 Cupin domain; Region: Cupin_2; cl09118 196164006128 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 196164006129 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 196164006130 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 196164006131 active site 196164006132 multimer interface [polypeptide binding]; other site 196164006133 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164006134 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 196164006135 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 196164006136 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 196164006137 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 196164006138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164006139 active site 196164006140 HIGH motif; other site 196164006141 nucleotide binding site [chemical binding]; other site 196164006142 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 196164006143 active site 196164006144 KMSKS motif; other site 196164006145 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 196164006146 tRNA binding surface [nucleotide binding]; other site 196164006147 anticodon binding site; other site 196164006148 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 196164006149 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 196164006150 malate dehydrogenase; Provisional; Region: PRK05442 196164006151 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 196164006152 NAD(P) binding site [chemical binding]; other site 196164006153 dimer interface [polypeptide binding]; other site 196164006154 malate binding site [chemical binding]; other site 196164006155 Helix-turn-helix domains; Region: HTH; cl00088 196164006156 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 196164006157 Membrane transport protein; Region: Mem_trans; cl09117 196164006158 Transposase domain (DUF772); Region: DUF772; cl12084 196164006159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164006160 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 196164006161 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 196164006162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164006163 Walker A motif; other site 196164006164 ATP binding site [chemical binding]; other site 196164006165 Walker B motif; other site 196164006166 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 196164006167 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164006168 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164006169 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 196164006170 Helix-turn-helix domains; Region: HTH; cl00088 196164006171 Bacterial transcriptional regulator; Region: IclR; pfam01614 196164006172 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 196164006173 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 196164006174 dimer interface [polypeptide binding]; other site 196164006175 active site 196164006176 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 196164006177 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 196164006178 nucleophilic elbow; other site 196164006179 catalytic triad; other site 196164006180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164006181 DNA binding residues [nucleotide binding] 196164006182 dimerization interface [polypeptide binding]; other site 196164006183 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 196164006184 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 196164006185 tetramer interface [polypeptide binding]; other site 196164006186 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 196164006187 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 196164006188 heterodimer interface [polypeptide binding]; other site 196164006189 active site 196164006190 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 196164006191 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 196164006192 active site 196164006193 Muconolactone delta-isomerase; Region: MIase; cl01992 196164006194 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 196164006195 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 196164006196 metal binding site [ion binding]; metal-binding site 196164006197 substrate binding pocket [chemical binding]; other site 196164006198 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 196164006199 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 196164006200 active site 196164006201 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 196164006202 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 196164006203 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 196164006204 putative alpha subunit interface [polypeptide binding]; other site 196164006205 putative active site [active] 196164006206 putative substrate binding site [chemical binding]; other site 196164006207 Fe binding site [ion binding]; other site 196164006208 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 196164006209 inter-subunit interface; other site 196164006210 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 196164006211 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 196164006212 catalytic loop [active] 196164006213 iron binding site [ion binding]; other site 196164006214 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 196164006215 FAD binding pocket [chemical binding]; other site 196164006216 FAD binding motif [chemical binding]; other site 196164006217 phosphate binding motif [ion binding]; other site 196164006218 beta-alpha-beta structure motif; other site 196164006219 NAD binding pocket [chemical binding]; other site 196164006220 FCD domain; Region: FCD; cl11656 196164006221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006222 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 196164006223 NAD(P) binding site [chemical binding]; other site 196164006224 active site 196164006225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006226 AAA domain; Region: AAA_22; pfam13401 196164006227 Predicted ATPase [General function prediction only]; Region: COG3899 196164006228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164006229 DNA binding residues [nucleotide binding] 196164006230 dimerization interface [polypeptide binding]; other site 196164006231 benzoate transport; Region: 2A0115; TIGR00895 196164006232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006233 putative substrate translocation pore; other site 196164006234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006235 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 196164006236 oligomer interface [polypeptide binding]; other site 196164006237 active site residues [active] 196164006238 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 196164006239 oligomer interface [polypeptide binding]; other site 196164006240 active site residues [active] 196164006241 trigger factor; Provisional; Region: tig; PRK01490 196164006242 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 196164006243 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 196164006244 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 196164006245 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 196164006246 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 196164006247 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 196164006248 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 196164006249 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 196164006250 Zn binding site [ion binding]; other site 196164006251 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196164006252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164006253 DNA-binding site [nucleotide binding]; DNA binding site 196164006254 UTRA domain; Region: UTRA; cl01230 196164006255 putative transposase OrfB; Reviewed; Region: PHA02517 196164006256 Integrase core domain; Region: rve; cl01316 196164006257 Integrase core domain; Region: rve_3; cl15866 196164006258 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 196164006259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164006260 HsdM N-terminal domain; Region: HsdM_N; pfam12161 196164006261 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 196164006262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164006263 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196164006264 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 196164006265 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 196164006266 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 196164006267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164006268 ATP binding site [chemical binding]; other site 196164006269 putative Mg++ binding site [ion binding]; other site 196164006270 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 196164006271 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 196164006272 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 196164006273 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 196164006274 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 196164006275 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 196164006276 Walker A/P-loop; other site 196164006277 ATP binding site [chemical binding]; other site 196164006278 Q-loop/lid; other site 196164006279 ABC transporter signature motif; other site 196164006280 Walker B; other site 196164006281 D-loop; other site 196164006282 H-loop/switch region; other site 196164006283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196164006284 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 196164006285 Walker A/P-loop; other site 196164006286 ATP binding site [chemical binding]; other site 196164006287 Q-loop/lid; other site 196164006288 ABC transporter signature motif; other site 196164006289 Walker B; other site 196164006290 D-loop; other site 196164006291 H-loop/switch region; other site 196164006292 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 196164006293 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 196164006294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164006295 putative PBP binding loops; other site 196164006296 ABC-ATPase subunit interface; other site 196164006297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 196164006298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 196164006299 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 196164006300 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 196164006301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 196164006302 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 196164006303 hypothetical protein; Provisional; Region: PRK06062 196164006304 inhibitor-cofactor binding pocket; inhibition site 196164006305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164006306 catalytic residue [active] 196164006307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006308 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 196164006309 NAD(P) binding site [chemical binding]; other site 196164006310 active site 196164006311 tetracycline repressor protein TetR; Provisional; Region: PRK13756 196164006312 Helix-turn-helix domains; Region: HTH; cl00088 196164006313 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 196164006314 Histidine kinase; Region: HisKA_3; pfam07730 196164006315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 196164006316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164006318 active site 196164006319 phosphorylation site [posttranslational modification] 196164006320 intermolecular recognition site; other site 196164006321 dimerization interface [polypeptide binding]; other site 196164006322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164006323 DNA binding residues [nucleotide binding] 196164006324 dimerization interface [polypeptide binding]; other site 196164006325 cystathionine gamma-synthase; Provisional; Region: PRK07811 196164006326 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 196164006327 homodimer interface [polypeptide binding]; other site 196164006328 substrate-cofactor binding pocket; other site 196164006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164006330 catalytic residue [active] 196164006331 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 196164006332 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006333 Walker A/P-loop; other site 196164006334 ATP binding site [chemical binding]; other site 196164006335 Q-loop/lid; other site 196164006336 ABC transporter signature motif; other site 196164006337 Walker B; other site 196164006338 D-loop; other site 196164006339 H-loop/switch region; other site 196164006340 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 196164006341 apolar tunnel; other site 196164006342 heme binding site [chemical binding]; other site 196164006343 dimerization interface [polypeptide binding]; other site 196164006344 Chromate transporter; Region: Chromate_transp; pfam02417 196164006345 Chromate transporter; Region: Chromate_transp; pfam02417 196164006346 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 196164006347 active site 196164006348 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 196164006349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006350 Walker A/P-loop; other site 196164006351 ATP binding site [chemical binding]; other site 196164006352 Q-loop/lid; other site 196164006353 ABC transporter signature motif; other site 196164006354 Walker B; other site 196164006355 D-loop; other site 196164006356 H-loop/switch region; other site 196164006357 ABC transporter; Region: ABC_tran_2; pfam12848 196164006358 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 196164006359 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196164006360 dimer interface [polypeptide binding]; other site 196164006361 ssDNA binding site [nucleotide binding]; other site 196164006362 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196164006363 Copper resistance protein D; Region: CopD; cl00563 196164006364 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 196164006365 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 196164006366 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 196164006367 transmembrane helices; other site 196164006368 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 196164006369 active site 196164006370 catalytic site [active] 196164006371 Zn binding site [ion binding]; other site 196164006372 tetramer interface [polypeptide binding]; other site 196164006373 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 196164006374 active site 196164006375 homotetramer interface [polypeptide binding]; other site 196164006376 homodimer interface [polypeptide binding]; other site 196164006377 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 196164006378 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 196164006379 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 196164006380 Ligand Binding Site [chemical binding]; other site 196164006381 AIR carboxylase; Region: AIRC; cl00310 196164006382 Protein of unknown function DUF111; Region: DUF111; cl03398 196164006383 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 196164006384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 196164006385 FeS/SAM binding site; other site 196164006386 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 196164006387 ATP cone domain; Region: ATP-cone; pfam03477 196164006388 Class III ribonucleotide reductase; Region: RNR_III; cd01675 196164006389 effector binding site; other site 196164006390 active site 196164006391 Zn binding site [ion binding]; other site 196164006392 glycine loop; other site 196164006393 Sensors of blue-light using FAD; Region: BLUF; cl04855 196164006394 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 196164006395 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 196164006396 Metal-binding active site; metal-binding site 196164006397 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 196164006398 classical (c) SDRs; Region: SDR_c; cd05233 196164006399 NAD(P) binding site [chemical binding]; other site 196164006400 active site 196164006401 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 196164006402 putative active site [active] 196164006403 putative substrate binding site [chemical binding]; other site 196164006404 catalytic site [active] 196164006405 dimer interface [polypeptide binding]; other site 196164006406 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 196164006407 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 196164006408 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164006409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 196164006410 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 196164006411 TspO/MBR family; Region: TspO_MBR; cl01379 196164006412 Glutaminase; Region: Glutaminase; cl00907 196164006413 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 196164006414 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196164006415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196164006416 DNA binding site [nucleotide binding] 196164006417 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 196164006418 ligand binding site [chemical binding]; other site 196164006419 dimerization interface [polypeptide binding]; other site 196164006420 Glucuronate isomerase; Region: UxaC; cl00829 196164006421 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 196164006422 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 196164006423 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 196164006424 domain; Region: Glyco_hydro_2; pfam00703 196164006425 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 196164006426 beta-D-glucuronidase; Provisional; Region: PRK10150 196164006427 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 196164006428 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 196164006429 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 196164006430 Glucuronate isomerase; Region: UxaC; cl00829 196164006431 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 196164006432 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 196164006433 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 196164006434 Isochorismatase family; Region: Isochorismatase; pfam00857 196164006435 catalytic triad [active] 196164006436 metal binding site [ion binding]; metal-binding site 196164006437 conserved cis-peptide bond; other site 196164006438 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 196164006439 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 196164006440 catalytic triad [active] 196164006441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164006442 Helix-turn-helix domains; Region: HTH; cl00088 196164006443 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 196164006444 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 196164006445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006446 putative substrate translocation pore; other site 196164006447 Amino acid permease; Region: AA_permease; cl00524 196164006448 Amino acid permease; Region: AA_permease; cl00524 196164006449 Acyl transferase domain; Region: Acyl_transf_1; cl08282 196164006450 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 196164006451 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 196164006452 phosphate binding site [ion binding]; other site 196164006453 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 196164006454 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 196164006455 putative active site [active] 196164006456 putative catalytic site [active] 196164006457 Acyl transferase domain; Region: Acyl_transf_1; cl08282 196164006458 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 196164006459 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 196164006460 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 196164006461 putative NAD(P) binding site [chemical binding]; other site 196164006462 active site 196164006463 'elongating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP) thioesters as...; Region: elong_cond_enzymes; cd00828 196164006464 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 196164006465 active site 196164006466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006467 active site 196164006468 Citrate transporter; Region: CitMHS; pfam03600 196164006469 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 196164006470 GntP family permease; Region: GntP_permease; cl15264 196164006471 Peptidase family M23; Region: Peptidase_M23; pfam01551 196164006472 Glucitol operon activator protein (GutM); Region: GutM; cl01890 196164006473 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 196164006474 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 196164006475 active site 196164006476 dimerization interface [polypeptide binding]; other site 196164006477 ribonuclease PH; Reviewed; Region: rph; PRK00173 196164006478 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 196164006479 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 196164006480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 196164006481 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 196164006482 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196164006483 Helix-turn-helix domains; Region: HTH; cl00088 196164006484 Rhomboid family; Region: Rhomboid; cl11446 196164006485 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 196164006486 putative active site pocket [active] 196164006487 cleavage site 196164006488 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 196164006489 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 196164006490 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 196164006491 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 196164006492 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 196164006493 active site 196164006494 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 196164006495 active site 196164006496 catalytic triad [active] 196164006497 oxyanion hole [active] 196164006498 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 196164006499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006500 DEAD_2; Region: DEAD_2; pfam06733 196164006501 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006502 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 196164006503 dimer interface [polypeptide binding]; other site 196164006504 putative active site [active] 196164006505 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 196164006506 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 196164006507 phosphoserine phosphatase SerB; Region: serB; TIGR00338 196164006508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164006509 motif II; other site 196164006510 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 196164006511 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 196164006512 D-pathway; other site 196164006513 Putative ubiquinol binding site [chemical binding]; other site 196164006514 Low-spin heme (heme b) binding site [chemical binding]; other site 196164006515 Putative water exit pathway; other site 196164006516 Binuclear center (heme o3/CuB) [ion binding]; other site 196164006517 K-pathway; other site 196164006518 Putative proton exit pathway; other site 196164006519 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 196164006520 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 196164006521 dimer interface [polypeptide binding]; other site 196164006522 putative radical transfer pathway; other site 196164006523 diiron center [ion binding]; other site 196164006524 tyrosyl radical; other site 196164006525 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 196164006526 Ferritin-like domain; Region: Ferritin; pfam00210 196164006527 ferroxidase diiron center [ion binding]; other site 196164006528 Transcriptional regulators [Transcription]; Region: FadR; COG2186 196164006529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164006530 DNA-binding site [nucleotide binding]; DNA binding site 196164006531 FCD domain; Region: FCD; cl11656 196164006532 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 196164006533 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 196164006534 Class I ribonucleotide reductase; Region: RNR_I; cd01679 196164006535 active site 196164006536 dimer interface [polypeptide binding]; other site 196164006537 catalytic residues [active] 196164006538 effector binding site; other site 196164006539 R2 peptide binding site; other site 196164006540 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 196164006541 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 196164006542 catalytic residues [active] 196164006543 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 196164006544 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 196164006545 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 196164006546 homodimer interface [polypeptide binding]; other site 196164006547 NAD binding pocket [chemical binding]; other site 196164006548 ATP binding pocket [chemical binding]; other site 196164006549 Mg binding site [ion binding]; other site 196164006550 active-site loop [active] 196164006551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 196164006552 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 196164006553 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 196164006554 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 196164006555 NADP binding site [chemical binding]; other site 196164006556 dimer interface [polypeptide binding]; other site 196164006557 phosphoglucomutase; Validated; Region: PRK07564 196164006558 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 196164006559 active site 196164006560 substrate binding site [chemical binding]; other site 196164006561 metal binding site [ion binding]; metal-binding site 196164006562 CrcB-like protein; Region: CRCB; cl09114 196164006563 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 196164006564 FtsX-like permease family; Region: FtsX; pfam02687 196164006565 FtsX-like permease family; Region: FtsX; pfam02687 196164006566 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 196164006567 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 196164006568 Walker A/P-loop; other site 196164006569 ATP binding site [chemical binding]; other site 196164006570 Q-loop/lid; other site 196164006571 ABC transporter signature motif; other site 196164006572 Walker B; other site 196164006573 D-loop; other site 196164006574 H-loop/switch region; other site 196164006575 Dehydratase family; Region: ILVD_EDD; cl00340 196164006576 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 196164006577 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 196164006578 hinge; other site 196164006579 active site 196164006580 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 196164006581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164006582 DNA binding residues [nucleotide binding] 196164006583 dimerization interface [polypeptide binding]; other site 196164006584 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 196164006585 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 196164006586 dimer interface [polypeptide binding]; other site 196164006587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164006588 catalytic residue [active] 196164006589 serine O-acetyltransferase; Region: cysE; TIGR01172 196164006590 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 196164006591 trimer interface [polypeptide binding]; other site 196164006592 active site 196164006593 substrate binding site [chemical binding]; other site 196164006594 CoA binding site [chemical binding]; other site 196164006595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196164006596 Coenzyme A binding pocket [chemical binding]; other site 196164006597 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 196164006598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006599 CoA-ligase; Region: Ligase_CoA; pfam00549 196164006600 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 196164006601 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164006602 CoA-ligase; Region: Ligase_CoA; pfam00549 196164006603 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 196164006604 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 196164006605 catalytic residues [active] 196164006606 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 196164006607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164006608 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 196164006609 active site 196164006610 catalytic site [active] 196164006611 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl15700 196164006612 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 196164006613 active site 196164006614 catalytic site [active] 196164006615 Gram positive anchor; Region: Gram_pos_anchor; cl15427 196164006616 Cytochrome P450; Region: p450; cl12078 196164006617 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164006618 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 196164006619 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 196164006620 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 196164006621 FMN binding site [chemical binding]; other site 196164006622 active site 196164006623 catalytic residues [active] 196164006624 substrate binding site [chemical binding]; other site 196164006625 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 196164006626 Cytochrome P450; Region: p450; cl12078 196164006627 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 196164006628 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 196164006629 Walker A/P-loop; other site 196164006630 ATP binding site [chemical binding]; other site 196164006631 Q-loop/lid; other site 196164006632 ABC transporter signature motif; other site 196164006633 Walker B; other site 196164006634 D-loop; other site 196164006635 H-loop/switch region; other site 196164006636 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 196164006637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164006638 dimer interface [polypeptide binding]; other site 196164006639 conserved gate region; other site 196164006640 putative PBP binding loops; other site 196164006641 ABC-ATPase subunit interface; other site 196164006642 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 196164006643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 196164006644 dimer interface [polypeptide binding]; other site 196164006645 conserved gate region; other site 196164006646 putative PBP binding loops; other site 196164006647 ABC-ATPase subunit interface; other site 196164006648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 196164006649 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 196164006650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 196164006651 Coenzyme A binding pocket [chemical binding]; other site 196164006652 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164006653 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 196164006654 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 196164006655 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 196164006656 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 196164006657 heme-binding site [chemical binding]; other site 196164006658 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 196164006659 Aminotransferase class IV; Region: Aminotran_4; pfam01063 196164006660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164006661 catalytic residue [active] 196164006662 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 196164006663 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 196164006664 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 196164006665 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 196164006666 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 196164006667 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 196164006668 dimerization interface [polypeptide binding]; other site 196164006669 putative ATP binding site [chemical binding]; other site 196164006670 amidophosphoribosyltransferase; Provisional; Region: PRK07847 196164006671 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 196164006672 active site 196164006673 tetramer interface [polypeptide binding]; other site 196164006674 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164006675 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 196164006676 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 196164006677 Haemolysin-III related; Region: HlyIII; cl03831 196164006678 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 196164006679 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 196164006680 dimerization interface [polypeptide binding]; other site 196164006681 ATP binding site [chemical binding]; other site 196164006682 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 196164006683 dimerization interface [polypeptide binding]; other site 196164006684 ATP binding site [chemical binding]; other site 196164006685 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 196164006686 putative active site [active] 196164006687 catalytic triad [active] 196164006688 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 196164006689 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 196164006690 catalytic residues [active] 196164006691 dimer interface [polypeptide binding]; other site 196164006692 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 196164006693 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 196164006694 generic binding surface II; other site 196164006695 generic binding surface I; other site 196164006696 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 196164006697 putative active site [active] 196164006698 putative catalytic site [active] 196164006699 putative Mg binding site IVb [ion binding]; other site 196164006700 putative phosphate binding site [ion binding]; other site 196164006701 putative DNA binding site [nucleotide binding]; other site 196164006702 putative Mg binding site IVa [ion binding]; other site 196164006703 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 196164006704 putative active site [active] 196164006705 putative Zn binding site [ion binding]; other site 196164006706 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 196164006707 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164006708 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 196164006709 ATP binding site [chemical binding]; other site 196164006710 active site 196164006711 substrate binding site [chemical binding]; other site 196164006712 adenylosuccinate lyase; Region: purB; TIGR00928 196164006713 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 196164006714 tetramer interface [polypeptide binding]; other site 196164006715 aspartate aminotransferase; Provisional; Region: PRK05764 196164006716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164006717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164006718 homodimer interface [polypeptide binding]; other site 196164006719 catalytic residue [active] 196164006720 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 196164006721 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 196164006722 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164006723 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 196164006724 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 196164006725 hydrophobic ligand binding site; other site 196164006726 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 196164006727 nucleotide binding site/active site [active] 196164006728 HIT family signature motif; other site 196164006729 catalytic residue [active] 196164006730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 196164006731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 196164006732 dimerization interface [polypeptide binding]; other site 196164006733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 196164006734 dimer interface [polypeptide binding]; other site 196164006735 phosphorylation site [posttranslational modification] 196164006736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164006737 ATP binding site [chemical binding]; other site 196164006738 Mg2+ binding site [ion binding]; other site 196164006739 G-X-G motif; other site 196164006740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 196164006741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164006742 active site 196164006743 phosphorylation site [posttranslational modification] 196164006744 intermolecular recognition site; other site 196164006745 dimerization interface [polypeptide binding]; other site 196164006746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 196164006747 DNA binding site [nucleotide binding] 196164006748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164006750 putative substrate translocation pore; other site 196164006751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006752 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 196164006753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006754 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 196164006755 active site 196164006756 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 196164006757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006758 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164006759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164006760 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 196164006761 active site 196164006762 motif I; other site 196164006763 motif II; other site 196164006764 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 196164006765 benzoate transporter; Region: benE; TIGR00843 196164006766 Helix-turn-helix domains; Region: HTH; cl00088 196164006767 Uncharacterized conserved protein [Function unknown]; Region: COG2966 196164006768 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 196164006769 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 196164006770 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 196164006771 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 196164006772 active site 196164006773 homotetramer interface [polypeptide binding]; other site 196164006774 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 196164006775 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 196164006776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 196164006777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 196164006778 DNA binding site [nucleotide binding] 196164006779 domain linker motif; other site 196164006780 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 196164006781 putative dimerization interface [polypeptide binding]; other site 196164006782 putative ligand binding site [chemical binding]; other site 196164006783 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 196164006784 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 196164006785 metal binding site [ion binding]; metal-binding site 196164006786 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 196164006787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006788 Walker A/P-loop; other site 196164006789 ATP binding site [chemical binding]; other site 196164006790 Q-loop/lid; other site 196164006791 ABC transporter signature motif; other site 196164006792 Walker B; other site 196164006793 D-loop; other site 196164006794 H-loop/switch region; other site 196164006795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 196164006796 dimer interface [polypeptide binding]; other site 196164006797 putative PBP binding regions; other site 196164006798 ABC-ATPase subunit interface; other site 196164006799 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 196164006800 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 196164006801 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 196164006802 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 196164006803 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 196164006804 active site 196164006805 HIGH motif; other site 196164006806 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 196164006807 KMSKS motif; other site 196164006808 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 196164006809 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 196164006810 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 196164006811 active site 196164006812 trimer interface [polypeptide binding]; other site 196164006813 allosteric site; other site 196164006814 active site lid [active] 196164006815 hexamer (dimer of trimers) interface [polypeptide binding]; other site 196164006816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164006817 DNA-binding site [nucleotide binding]; DNA binding site 196164006818 FCD domain; Region: FCD; cl11656 196164006819 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 196164006820 homotrimer interaction site [polypeptide binding]; other site 196164006821 zinc binding site [ion binding]; other site 196164006822 CDP-binding sites; other site 196164006823 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 196164006824 substrate binding site; other site 196164006825 dimer interface; other site 196164006826 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 196164006827 DNA repair protein RadA; Provisional; Region: PRK11823 196164006828 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006829 Walker A motif; other site 196164006830 ATP binding site [chemical binding]; other site 196164006831 Walker B motif; other site 196164006832 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 196164006833 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 196164006834 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 196164006835 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 196164006836 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 196164006837 active site clefts [active] 196164006838 zinc binding site [ion binding]; other site 196164006839 dimer interface [polypeptide binding]; other site 196164006840 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 196164006841 endonuclease III; Region: ENDO3c; smart00478 196164006842 minor groove reading motif; other site 196164006843 helix-hairpin-helix signature motif; other site 196164006844 substrate binding pocket [chemical binding]; other site 196164006845 active site 196164006846 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 196164006847 Clp protease ATP binding subunit; Region: clpC; CHL00095 196164006848 Clp amino terminal domain; Region: Clp_N; pfam02861 196164006849 Clp amino terminal domain; Region: Clp_N; pfam02861 196164006850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164006851 Walker A motif; other site 196164006852 ATP binding site [chemical binding]; other site 196164006853 Walker B motif; other site 196164006854 arginine finger; other site 196164006855 UvrB/uvrC motif; Region: UVR; pfam02151 196164006856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164006857 Walker A motif; other site 196164006858 ATP binding site [chemical binding]; other site 196164006859 Walker B motif; other site 196164006860 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 196164006861 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 196164006862 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 196164006863 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 196164006864 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 196164006865 active site 196164006866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006867 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 196164006868 putative substrate translocation pore; other site 196164006869 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 196164006870 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 196164006871 dimer interface [polypeptide binding]; other site 196164006872 putative anticodon binding site; other site 196164006873 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 196164006874 motif 1; other site 196164006875 active site 196164006876 motif 2; other site 196164006877 motif 3; other site 196164006878 pantoate--beta-alanine ligase; Region: panC; TIGR00018 196164006879 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164006880 active site 196164006881 nucleotide binding site [chemical binding]; other site 196164006882 HIGH motif; other site 196164006883 KMSKS motif; other site 196164006884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164006885 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 196164006886 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 196164006887 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 196164006888 catalytic center binding site [active] 196164006889 ATP binding site [chemical binding]; other site 196164006890 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 196164006891 homooctamer interface [polypeptide binding]; other site 196164006892 active site 196164006893 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 196164006894 dihydropteroate synthase; Region: DHPS; TIGR01496 196164006895 substrate binding pocket [chemical binding]; other site 196164006896 dimer interface [polypeptide binding]; other site 196164006897 inhibitor binding site; inhibition site 196164006898 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 196164006899 homodecamer interface [polypeptide binding]; other site 196164006900 GTP cyclohydrolase I; Provisional; Region: PLN03044 196164006901 active site 196164006902 putative catalytic site residues [active] 196164006903 zinc binding site [ion binding]; other site 196164006904 GTP-CH-I/GFRP interaction surface; other site 196164006905 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 196164006906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164006907 Walker A motif; other site 196164006908 ATP binding site [chemical binding]; other site 196164006909 Walker B motif; other site 196164006910 arginine finger; other site 196164006911 Peptidase family M41; Region: Peptidase_M41; pfam01434 196164006912 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164006913 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 196164006914 Ligand Binding Site [chemical binding]; other site 196164006915 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 196164006916 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 196164006917 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 196164006918 dimer interface [polypeptide binding]; other site 196164006919 substrate binding site [chemical binding]; other site 196164006920 metal binding sites [ion binding]; metal-binding site 196164006921 spermidine synthase; Provisional; Region: PRK03612 196164006922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164006923 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 196164006924 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 196164006925 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 196164006926 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 196164006927 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 196164006928 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164006929 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196164006930 Helix-turn-helix domains; Region: HTH; cl00088 196164006931 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164006932 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 196164006933 Phosphopantetheine attachment site; Region: PP-binding; cl09936 196164006934 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 196164006935 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196164006936 putative trimer interface [polypeptide binding]; other site 196164006937 putative CoA binding site [chemical binding]; other site 196164006938 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 196164006939 putative trimer interface [polypeptide binding]; other site 196164006940 putative CoA binding site [chemical binding]; other site 196164006941 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 196164006942 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 196164006943 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 196164006944 ring oligomerisation interface [polypeptide binding]; other site 196164006945 ATP/Mg binding site [chemical binding]; other site 196164006946 stacking interactions; other site 196164006947 hinge regions; other site 196164006948 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 196164006949 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 196164006950 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 196164006951 active site 196164006952 metal binding site [ion binding]; metal-binding site 196164006953 dimer interface [polypeptide binding]; other site 196164006954 2-isopropylmalate synthase; Validated; Region: PRK03739 196164006955 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 196164006956 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164006957 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 196164006958 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 196164006959 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 196164006960 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 196164006961 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 196164006962 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 196164006963 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 196164006964 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 196164006965 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 196164006966 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 196164006967 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 196164006968 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 196164006969 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 196164006970 active site 196164006971 catalytic residues [active] 196164006972 metal binding site [ion binding]; metal-binding site 196164006973 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164006974 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 196164006975 putative phosphate binding site [ion binding]; other site 196164006976 putative catalytic site [active] 196164006977 active site 196164006978 metal binding site A [ion binding]; metal-binding site 196164006979 DNA binding site [nucleotide binding] 196164006980 putative AP binding site [nucleotide binding]; other site 196164006981 putative metal binding site B [ion binding]; other site 196164006982 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 196164006983 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 196164006984 putative active site [active] 196164006985 catalytic site [active] 196164006986 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 196164006987 putative active site [active] 196164006988 catalytic site [active] 196164006989 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 196164006990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164006991 putative substrate translocation pore; other site 196164006992 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 196164006993 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 196164006994 ABC-2 type transporter; Region: ABC2_membrane; cl11417 196164006995 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 196164006996 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164006997 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164006998 Walker A/P-loop; other site 196164006999 ATP binding site [chemical binding]; other site 196164007000 Q-loop/lid; other site 196164007001 ABC transporter signature motif; other site 196164007002 Walker B; other site 196164007003 D-loop; other site 196164007004 H-loop/switch region; other site 196164007005 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 196164007006 nudix motif; other site 196164007007 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 196164007008 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 196164007009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196164007010 substrate binding pocket [chemical binding]; other site 196164007011 membrane-bound complex binding site; other site 196164007012 hinge residues; other site 196164007013 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 196164007014 Catalytic domain of Protein Kinases; Region: PKc; cd00180 196164007015 active site 196164007016 ATP binding site [chemical binding]; other site 196164007017 substrate binding site [chemical binding]; other site 196164007018 activation loop (A-loop); other site 196164007019 Acetokinase family; Region: Acetate_kinase; cl01029 196164007020 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 196164007021 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 196164007022 ferredoxin-NADP+ reductase; Region: PLN02852 196164007023 hypothetical protein; Provisional; Region: PRK09897 196164007024 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164007025 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 196164007026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007027 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 196164007028 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196164007029 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 196164007030 metal binding site [ion binding]; metal-binding site 196164007031 putative dimer interface [polypeptide binding]; other site 196164007032 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 196164007033 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 196164007034 GDP-binding site [chemical binding]; other site 196164007035 ACT binding site; other site 196164007036 IMP binding site; other site 196164007037 lipid kinase; Reviewed; Region: PRK13054 196164007038 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 196164007039 Predicted membrane protein [Function unknown]; Region: COG4129 196164007040 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 196164007041 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 196164007042 active site 196164007043 intersubunit interface [polypeptide binding]; other site 196164007044 zinc binding site [ion binding]; other site 196164007045 Na+ binding site [ion binding]; other site 196164007046 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 196164007047 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 196164007048 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 196164007049 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 196164007050 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 196164007051 active site residue [active] 196164007052 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 196164007053 active site residue [active] 196164007054 H+ Antiporter protein; Region: 2A0121; TIGR00900 196164007055 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 196164007056 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 196164007057 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 196164007058 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 196164007059 Clp amino terminal domain; Region: Clp_N; pfam02861 196164007060 Clp amino terminal domain; Region: Clp_N; pfam02861 196164007061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164007062 Walker A motif; other site 196164007063 ATP binding site [chemical binding]; other site 196164007064 Walker B motif; other site 196164007065 arginine finger; other site 196164007066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164007067 Walker A motif; other site 196164007068 ATP binding site [chemical binding]; other site 196164007069 Walker B motif; other site 196164007070 arginine finger; other site 196164007071 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 196164007072 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 196164007073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164007074 Helix-turn-helix domains; Region: HTH; cl00088 196164007075 putative transposase OrfB; Reviewed; Region: PHA02517 196164007076 Integrase core domain; Region: rve; cl01316 196164007077 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 196164007078 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164007079 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 196164007080 FAD binding pocket [chemical binding]; other site 196164007081 FAD binding motif [chemical binding]; other site 196164007082 phosphate binding motif [ion binding]; other site 196164007083 beta-alpha-beta structure motif; other site 196164007084 NAD binding pocket [chemical binding]; other site 196164007085 Predicted amidohydrolase [General function prediction only]; Region: COG0388 196164007086 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 196164007087 putative active site [active] 196164007088 catalytic triad [active] 196164007089 putative dimer interface [polypeptide binding]; other site 196164007090 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 196164007091 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 196164007092 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 196164007093 NAD(P) binding site [chemical binding]; other site 196164007094 catalytic residues [active] 196164007095 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 196164007096 DNA binding residues [nucleotide binding] 196164007097 putative dimer interface [polypeptide binding]; other site 196164007098 chaperone protein DnaJ; Provisional; Region: PRK14279 196164007099 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 196164007100 HSP70 interaction site [polypeptide binding]; other site 196164007101 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 196164007102 Zn binding sites [ion binding]; other site 196164007103 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 196164007104 dimer interface [polypeptide binding]; other site 196164007105 heat shock protein GrpE; Provisional; Region: PRK14140 196164007106 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 196164007107 dimer interface [polypeptide binding]; other site 196164007108 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 196164007109 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 196164007110 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 196164007111 ATP binding site [chemical binding]; other site 196164007112 profilin binding site; other site 196164007113 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 196164007114 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 196164007115 Catalytic site [active] 196164007116 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 196164007117 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 196164007118 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 196164007119 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164007120 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 196164007121 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 196164007122 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 196164007123 putative active site [active] 196164007124 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 196164007125 active site 196164007126 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 196164007127 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 196164007128 CysD dimerization site [polypeptide binding]; other site 196164007129 G1 box; other site 196164007130 putative GEF interaction site [polypeptide binding]; other site 196164007131 GTP/Mg2+ binding site [chemical binding]; other site 196164007132 Switch I region; other site 196164007133 G2 box; other site 196164007134 G3 box; other site 196164007135 Switch II region; other site 196164007136 G4 box; other site 196164007137 G5 box; other site 196164007138 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 196164007139 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 196164007140 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 196164007141 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 196164007142 Active Sites [active] 196164007143 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 196164007144 Active Sites [active] 196164007145 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 196164007146 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196164007147 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 196164007148 ferredoxin-NADP+ reductase; Region: PLN02852 196164007149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007150 NAD(P) binding pocket [chemical binding]; other site 196164007151 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 196164007152 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 196164007153 dimer interface [polypeptide binding]; other site 196164007154 FMN binding site [chemical binding]; other site 196164007155 NADPH bind site [chemical binding]; other site 196164007156 Predicted ATPase [General function prediction only]; Region: COG3910 196164007157 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 196164007158 Walker A/P-loop; other site 196164007159 ATP binding site [chemical binding]; other site 196164007160 Q-loop/lid; other site 196164007161 ABC transporter signature motif; other site 196164007162 Walker B; other site 196164007163 D-loop; other site 196164007164 H-loop/switch region; other site 196164007165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164007166 Walker A/P-loop; other site 196164007167 ATP binding site [chemical binding]; other site 196164007168 Q-loop/lid; other site 196164007169 ABC transporter signature motif; other site 196164007170 Walker B; other site 196164007171 D-loop; other site 196164007172 H-loop/switch region; other site 196164007173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164007175 putative substrate translocation pore; other site 196164007176 Predicted membrane protein [Function unknown]; Region: COG2364 196164007177 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 196164007178 Domain of unknown function (DUF1994); Region: DUF1994; cl09179 196164007179 Excalibur calcium-binding domain; Region: Excalibur; cl05460 196164007180 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 196164007181 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 196164007182 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 196164007183 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 196164007184 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 196164007185 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 196164007186 heme-binding site [chemical binding]; other site 196164007187 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 196164007188 FAD binding pocket [chemical binding]; other site 196164007189 FAD binding motif [chemical binding]; other site 196164007190 phosphate binding motif [ion binding]; other site 196164007191 beta-alpha-beta structure motif; other site 196164007192 NAD binding pocket [chemical binding]; other site 196164007193 Heme binding pocket [chemical binding]; other site 196164007194 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 196164007195 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 196164007196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007197 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 196164007198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 196164007199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164007200 homodimer interface [polypeptide binding]; other site 196164007201 catalytic residue [active] 196164007202 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 196164007203 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 196164007204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007205 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 196164007206 trimer interface [polypeptide binding]; other site 196164007207 active site 196164007208 BCCT family transporter; Region: BCCT; cl00569 196164007209 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 196164007210 substrate binding pocket [chemical binding]; other site 196164007211 Cation efflux family; Region: Cation_efflux; cl00316 196164007212 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 196164007213 VanW like protein; Region: VanW; pfam04294 196164007214 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 196164007215 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196164007216 Ligand Binding Site [chemical binding]; other site 196164007217 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 196164007218 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 196164007219 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 196164007220 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 196164007221 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 196164007222 Walker A/P-loop; other site 196164007223 ATP binding site [chemical binding]; other site 196164007224 Q-loop/lid; other site 196164007225 ABC transporter signature motif; other site 196164007226 Walker B; other site 196164007227 D-loop; other site 196164007228 H-loop/switch region; other site 196164007229 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 196164007230 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 196164007231 putative ligand binding residues [chemical binding]; other site 196164007232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 196164007233 dimer interface [polypeptide binding]; other site 196164007234 putative PBP binding regions; other site 196164007235 ABC-ATPase subunit interface; other site 196164007236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 196164007237 dimerization interface [polypeptide binding]; other site 196164007238 putative DNA binding site [nucleotide binding]; other site 196164007239 putative Zn2+ binding site [ion binding]; other site 196164007240 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 196164007241 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 196164007242 putative peptidoglycan binding site; other site 196164007243 OpgC protein; Region: OpgC_C; cl00792 196164007244 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 196164007245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 196164007246 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 196164007247 Divergent AAA domain; Region: AAA_4; pfam04326 196164007248 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 196164007249 Protein of unknown function (DUF421); Region: DUF421; cl00990 196164007250 Methyltransferase domain; Region: Methyltransf_31; pfam13847 196164007251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164007252 S-adenosylmethionine binding site [chemical binding]; other site 196164007253 proline/glycine betaine transporter; Provisional; Region: PRK10642 196164007254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007255 putative substrate translocation pore; other site 196164007256 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 196164007257 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 196164007258 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 196164007259 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 196164007260 active site 196164007261 substrate-binding site [chemical binding]; other site 196164007262 metal-binding site [ion binding] 196164007263 GTP binding site [chemical binding]; other site 196164007264 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 196164007265 gating phenylalanine in ion channel; other site 196164007266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 196164007267 S-adenosylmethionine binding site [chemical binding]; other site 196164007268 LabA_like proteins; Region: LabA_like; cd06167 196164007269 putative metal binding site [ion binding]; other site 196164007270 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 196164007271 Predicted integral membrane protein [Function unknown]; Region: COG0392 196164007272 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 196164007273 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 196164007274 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 196164007275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 196164007276 Walker A motif; other site 196164007277 ATP binding site [chemical binding]; other site 196164007278 Walker B motif; other site 196164007279 Integrase core domain; Region: rve; cl01316 196164007280 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 196164007281 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 196164007282 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 196164007283 Phosphopantetheine attachment site; Region: PP-binding; cl09936 196164007284 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 196164007285 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 196164007286 active site 196164007287 Acyl transferase domain; Region: Acyl_transf_1; cl08282 196164007288 Phosphopantetheine attachment site; Region: PP-binding; cl09936 196164007289 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 196164007290 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 196164007291 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164007292 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164007293 Cutinase; Region: Cutinase; cl15711 196164007294 Predicted esterase [General function prediction only]; Region: COG0627 196164007295 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164007296 LGFP repeat; Region: LGFP; pfam08310 196164007297 LGFP repeat; Region: LGFP; pfam08310 196164007298 LGFP repeat; Region: LGFP; pfam08310 196164007299 Predicted esterase [General function prediction only]; Region: COG0627 196164007300 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 196164007301 UbiA prenyltransferase family; Region: UbiA; cl00337 196164007302 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 196164007303 active site 196164007304 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 196164007305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 196164007306 benzoate transport; Region: 2A0115; TIGR00895 196164007307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007308 putative substrate translocation pore; other site 196164007309 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 196164007310 active site 196164007311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007312 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 196164007313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007314 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 196164007315 amidase catalytic site [active] 196164007316 Zn binding residues [ion binding]; other site 196164007317 substrate binding site [chemical binding]; other site 196164007318 LGFP repeat; Region: LGFP; pfam08310 196164007319 glycerol kinase; Provisional; Region: glpK; PRK00047 196164007320 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 196164007321 N- and C-terminal domain interface [polypeptide binding]; other site 196164007322 putative active site [active] 196164007323 putative MgATP binding site [chemical binding]; other site 196164007324 catalytic site [active] 196164007325 metal binding site [ion binding]; metal-binding site 196164007326 putative homotetramer interface [polypeptide binding]; other site 196164007327 putative glycerol binding site [chemical binding]; other site 196164007328 homodimer interface [polypeptide binding]; other site 196164007329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164007330 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 196164007331 active site 196164007332 motif I; other site 196164007333 motif II; other site 196164007334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164007335 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 196164007336 putative acyl-acceptor binding pocket; other site 196164007337 seryl-tRNA synthetase; Provisional; Region: PRK05431 196164007338 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 196164007339 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 196164007340 dimer interface [polypeptide binding]; other site 196164007341 active site 196164007342 motif 1; other site 196164007343 motif 2; other site 196164007344 motif 3; other site 196164007345 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 196164007346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164007347 DNA-binding site [nucleotide binding]; DNA binding site 196164007348 UTRA domain; Region: UTRA; cl01230 196164007349 Septum formation; Region: Septum_form; pfam13845 196164007350 Septum formation; Region: Septum_form; pfam13845 196164007351 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 196164007352 YeeE/YedE family (DUF395); Region: DUF395; cl01018 196164007353 putative inner membrane protein; Provisional; Region: PRK11099 196164007354 putative inner membrane protein; Provisional; Region: PRK11099 196164007355 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 196164007356 CPxP motif; other site 196164007357 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 196164007358 DNA-binding site [nucleotide binding]; DNA binding site 196164007359 RNA-binding motif; other site 196164007360 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 196164007361 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164007362 catalytic core [active] 196164007363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 196164007364 prephenate dehydratase; Provisional; Region: PRK11898 196164007365 Prephenate dehydratase; Region: PDT; pfam00800 196164007366 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 196164007367 putative L-Phe binding site [chemical binding]; other site 196164007368 Amidase; Region: Amidase; cl11426 196164007369 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 196164007370 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 196164007371 active site 196164007372 catalytic site [active] 196164007373 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 196164007374 active site 196164007375 catalytic site [active] 196164007376 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 196164007377 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 196164007378 metal binding site [ion binding]; metal-binding site 196164007379 putative dimer interface [polypeptide binding]; other site 196164007380 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 196164007381 Helix-turn-helix domains; Region: HTH; cl00088 196164007382 Helix-turn-helix domains; Region: HTH; cl00088 196164007383 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 196164007384 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 196164007385 Helix-turn-helix domains; Region: HTH; cl00088 196164007386 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 196164007387 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 196164007388 putative active site [active] 196164007389 catalytic site [active] 196164007390 putative metal binding site [ion binding]; other site 196164007391 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 196164007392 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 196164007393 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 196164007394 active site 196164007395 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 196164007396 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 196164007397 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196164007398 NAD binding site [chemical binding]; other site 196164007399 dimer interface [polypeptide binding]; other site 196164007400 substrate binding site [chemical binding]; other site 196164007401 Predicted membrane protein (DUF2319); Region: DUF2319; cl15412 196164007402 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 196164007403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 196164007404 motif II; other site 196164007405 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 196164007406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164007407 DNA-binding site [nucleotide binding]; DNA binding site 196164007408 FCD domain; Region: FCD; cl11656 196164007409 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 196164007410 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 196164007411 active site 196164007412 metal binding site [ion binding]; metal-binding site 196164007413 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 196164007414 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 196164007415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007416 metabolite-proton symporter; Region: 2A0106; TIGR00883 196164007417 putative substrate translocation pore; other site 196164007418 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 196164007419 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 196164007420 active site 196164007421 substrate binding site [chemical binding]; other site 196164007422 FMN binding site [chemical binding]; other site 196164007423 putative catalytic residues [active] 196164007424 Scramblase; Region: Scramblase; cl02043 196164007425 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 196164007426 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 196164007427 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 196164007428 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 196164007429 BCCT family transporter; Region: BCCT; cl00569 196164007430 Helix-turn-helix domains; Region: HTH; cl00088 196164007431 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 196164007432 putative dimerization interface [polypeptide binding]; other site 196164007433 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 196164007434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007435 putative substrate translocation pore; other site 196164007436 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 196164007437 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 196164007438 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 196164007439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007440 NAD(P) binding site [chemical binding]; other site 196164007441 active site 196164007442 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 196164007443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164007444 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 196164007445 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 196164007446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164007447 substrate binding site [chemical binding]; other site 196164007448 oxyanion hole (OAH) forming residues; other site 196164007449 trimer interface [polypeptide binding]; other site 196164007450 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 196164007451 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 196164007452 acyl-coenzyme A oxidase; Region: PLN02526 196164007453 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 196164007454 active site 196164007455 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 196164007456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007457 NAD(P) binding site [chemical binding]; other site 196164007458 active site 196164007459 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 196164007460 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 196164007461 active site 196164007462 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 196164007463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 196164007464 substrate binding site [chemical binding]; other site 196164007465 oxyanion hole (OAH) forming residues; other site 196164007466 trimer interface [polypeptide binding]; other site 196164007467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164007468 Helix-turn-helix domains; Region: HTH; cl00088 196164007469 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 196164007470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164007471 active site 196164007472 phosphorylation site [posttranslational modification] 196164007473 intermolecular recognition site; other site 196164007474 dimerization interface [polypeptide binding]; other site 196164007475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 196164007476 DNA binding residues [nucleotide binding] 196164007477 dimerization interface [polypeptide binding]; other site 196164007478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 196164007479 Histidine kinase; Region: HisKA_3; pfam07730 196164007480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164007481 ATP binding site [chemical binding]; other site 196164007482 Mg2+ binding site [ion binding]; other site 196164007483 G-X-G motif; other site 196164007484 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 196164007485 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 196164007486 active site 196164007487 catalytic site [active] 196164007488 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 196164007489 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 196164007490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164007491 Helix-turn-helix domains; Region: HTH; cl00088 196164007492 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 196164007493 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196164007494 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196164007495 Ligand Binding Site [chemical binding]; other site 196164007496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 196164007497 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 196164007498 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 196164007499 active site 196164007500 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 196164007501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007502 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164007503 MULE transposase domain; Region: MULE; pfam10551 196164007504 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164007505 Domain of unknown function (DUF4324); Region: DUF4324; pfam14212 196164007506 Predicted transcriptional regulators [Transcription]; Region: COG1725 196164007507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 196164007508 DNA-binding site [nucleotide binding]; DNA binding site 196164007509 LabA_like proteins; Region: LabA_like; cd06167 196164007510 putative metal binding site [ion binding]; other site 196164007511 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 196164007512 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196164007513 catalytic residues [active] 196164007514 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 196164007515 metal-binding site [ion binding] 196164007516 benzoate transport; Region: 2A0115; TIGR00895 196164007517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007518 putative substrate translocation pore; other site 196164007519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007520 Helix-turn-helix domains; Region: HTH; cl00088 196164007521 replicative DNA helicase; Provisional; Region: PRK05636 196164007522 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 196164007523 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 196164007524 Walker A motif; other site 196164007525 ATP binding site [chemical binding]; other site 196164007526 Walker B motif; other site 196164007527 DNA binding loops [nucleotide binding] 196164007528 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 196164007529 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 196164007530 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 196164007531 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 196164007532 dimer interface [polypeptide binding]; other site 196164007533 ssDNA binding site [nucleotide binding]; other site 196164007534 tetramer (dimer of dimers) interface [polypeptide binding]; other site 196164007535 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 196164007536 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 196164007537 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 196164007538 Transglycosylase; Region: Transgly; cl07896 196164007539 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 196164007540 Helix-turn-helix domains; Region: HTH; cl00088 196164007541 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196164007542 Ligand Binding Site [chemical binding]; other site 196164007543 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 196164007544 Ligand Binding Site [chemical binding]; other site 196164007545 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 196164007546 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 196164007547 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 196164007548 active site residue [active] 196164007549 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 196164007550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 196164007551 hypothetical protein; Provisional; Region: PRK13663 196164007552 Ferritin-like domain; Region: Ferritin; pfam00210 196164007553 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 196164007554 dimerization interface [polypeptide binding]; other site 196164007555 DPS ferroxidase diiron center [ion binding]; other site 196164007556 ion pore; other site 196164007557 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 196164007558 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 196164007559 putative DNA binding site [nucleotide binding]; other site 196164007560 catalytic residue [active] 196164007561 putative H2TH interface [polypeptide binding]; other site 196164007562 putative catalytic residues [active] 196164007563 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 196164007564 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 196164007565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 196164007566 hypothetical protein; Reviewed; Region: PRK09588 196164007567 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 196164007568 Helix-turn-helix domains; Region: HTH; cl00088 196164007569 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 196164007570 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 196164007571 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 196164007572 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 196164007573 DNA binding site [nucleotide binding] 196164007574 active site 196164007575 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 196164007576 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 196164007577 putative NAD(P) binding site [chemical binding]; other site 196164007578 dimer interface [polypeptide binding]; other site 196164007579 Malic enzyme, N-terminal domain; Region: malic; pfam00390 196164007580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007581 NAD(P) binding pocket [chemical binding]; other site 196164007582 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 196164007583 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 196164007584 N- and C-terminal domain interface [polypeptide binding]; other site 196164007585 putative active site [active] 196164007586 catalytic site [active] 196164007587 metal binding site [ion binding]; metal-binding site 196164007588 carbohydrate binding site [chemical binding]; other site 196164007589 ATP binding site [chemical binding]; other site 196164007590 VanZ like family; Region: VanZ; cl01971 196164007591 VanZ like family; Region: VanZ; cl01971 196164007592 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196164007593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007594 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 196164007595 putative FMN binding site [chemical binding]; other site 196164007596 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 196164007597 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 196164007598 HIGH motif; other site 196164007599 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164007600 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 196164007601 active site 196164007602 KMSKS motif; other site 196164007603 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 196164007604 tRNA binding surface [nucleotide binding]; other site 196164007605 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 196164007606 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 196164007607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007608 putative substrate translocation pore; other site 196164007609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 196164007610 non-specific DNA binding site [nucleotide binding]; other site 196164007611 salt bridge; other site 196164007612 sequence-specific DNA binding site [nucleotide binding]; other site 196164007613 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 196164007614 [2Fe-2S] cluster binding site [ion binding]; other site 196164007615 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 196164007616 G1 box; other site 196164007617 GTP/Mg2+ binding site [chemical binding]; other site 196164007618 Switch I region; other site 196164007619 G2 box; other site 196164007620 Switch II region; other site 196164007621 G3 box; other site 196164007622 G5 box; other site 196164007623 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 196164007624 Switch I region; other site 196164007625 G2 box; other site 196164007626 Switch II region; other site 196164007627 G3 box; other site 196164007628 G4 box; other site 196164007629 G5 box; other site 196164007630 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 196164007631 G1 box; other site 196164007632 GTP/Mg2+ binding site [chemical binding]; other site 196164007633 Switch I region; other site 196164007634 G2 box; other site 196164007635 Switch II region; other site 196164007636 G3 box; other site 196164007637 G4 box; other site 196164007638 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 196164007639 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 196164007640 DinB superfamily; Region: DinB_2; cl00986 196164007641 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 196164007642 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 196164007643 Cupin domain; Region: Cupin_2; cl09118 196164007644 Transcriptional regulator [Transcription]; Region: IclR; COG1414 196164007645 Helix-turn-helix domains; Region: HTH; cl00088 196164007646 Bacterial transcriptional regulator; Region: IclR; pfam01614 196164007647 benzoate transport; Region: 2A0115; TIGR00895 196164007648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007649 putative substrate translocation pore; other site 196164007650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007651 salicylate hydroxylase; Provisional; Region: PRK08163 196164007652 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 196164007653 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 196164007654 anthranilate synthase component I; Provisional; Region: PRK13564 196164007655 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 196164007656 chorismate binding enzyme; Region: Chorismate_bind; cl10555 196164007657 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 196164007658 Glutamine amidotransferase class-I; Region: GATase; pfam00117 196164007659 glutamine binding [chemical binding]; other site 196164007660 catalytic triad [active] 196164007661 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 196164007662 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 196164007663 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 196164007664 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 196164007665 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 196164007666 active site 196164007667 ribulose/triose binding site [chemical binding]; other site 196164007668 phosphate binding site [ion binding]; other site 196164007669 substrate (anthranilate) binding pocket [chemical binding]; other site 196164007670 product (indole) binding pocket [chemical binding]; other site 196164007671 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 196164007672 active site 196164007673 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 196164007674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164007675 catalytic residue [active] 196164007676 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 196164007677 substrate binding site [chemical binding]; other site 196164007678 active site 196164007679 catalytic residues [active] 196164007680 heterodimer interface [polypeptide binding]; other site 196164007681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 196164007682 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 196164007683 Walker A/P-loop; other site 196164007684 ATP binding site [chemical binding]; other site 196164007685 Q-loop/lid; other site 196164007686 ABC transporter signature motif; other site 196164007687 Walker B; other site 196164007688 D-loop; other site 196164007689 H-loop/switch region; other site 196164007690 ABC-2 type transporter; Region: ABC2_membrane; cl11417 196164007691 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 196164007692 iron-sulfur cluster [ion binding]; other site 196164007693 [2Fe-2S] cluster binding site [ion binding]; other site 196164007694 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 196164007695 active site 196164007696 FMN binding site [chemical binding]; other site 196164007697 substrate binding site [chemical binding]; other site 196164007698 homotetramer interface [polypeptide binding]; other site 196164007699 catalytic residue [active] 196164007700 Membrane transport protein; Region: Mem_trans; cl09117 196164007701 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 196164007702 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 196164007703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 196164007704 catalytic residue [active] 196164007705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 196164007706 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 196164007707 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 196164007708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007709 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 196164007710 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 196164007711 [2Fe-2S] cluster binding site [ion binding]; other site 196164007712 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 196164007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 196164007714 putative substrate translocation pore; other site 196164007715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 196164007716 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 196164007717 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 196164007718 active site 196164007719 dimer interface [polypeptide binding]; other site 196164007720 metal binding site [ion binding]; metal-binding site 196164007721 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 196164007722 putative NAD(P) binding site [chemical binding]; other site 196164007723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164007724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164007725 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 196164007726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164007727 ATP binding site [chemical binding]; other site 196164007728 putative Mg++ binding site [ion binding]; other site 196164007729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164007730 ATP-binding site [chemical binding]; other site 196164007731 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 196164007732 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 196164007733 RloB-like protein; Region: RloB; pfam13707 196164007734 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 196164007735 DEAD-like helicases superfamily; Region: DEXDc; smart00487 196164007736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 196164007737 ATP binding site [chemical binding]; other site 196164007738 putative Mg++ binding site [ion binding]; other site 196164007739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 196164007740 nucleotide binding region [chemical binding]; other site 196164007741 ATP-binding site [chemical binding]; other site 196164007742 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 196164007743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007744 NAD(P) binding site [chemical binding]; other site 196164007745 active site 196164007746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 196164007747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 196164007748 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 196164007749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 196164007750 active site 196164007751 phosphorylation site [posttranslational modification] 196164007752 intermolecular recognition site; other site 196164007753 dimerization interface [polypeptide binding]; other site 196164007754 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 196164007755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 196164007756 ATP binding site [chemical binding]; other site 196164007757 Mg2+ binding site [ion binding]; other site 196164007758 G-X-G motif; other site 196164007759 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 196164007760 Citrate transporter; Region: CitMHS; pfam03600 196164007761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007762 OsmC-like protein; Region: OsmC; cl00767 196164007763 Transcriptional regulators [Transcription]; Region: MarR; COG1846 196164007764 Helix-turn-helix domains; Region: HTH; cl00088 196164007765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 196164007766 Helix-turn-helix domains; Region: HTH; cl00088 196164007767 Protein of unknown function (DUF3607); Region: DUF3607; pfam12245 196164007768 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 196164007769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 196164007770 putative active site [active] 196164007771 putative metal binding site [ion binding]; other site 196164007772 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 196164007773 putative transposase OrfB; Reviewed; Region: PHA02517 196164007774 Integrase core domain; Region: rve; cl01316 196164007775 Helix-turn-helix domains; Region: HTH; cl00088 196164007776 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 196164007777 substrate binding site [chemical binding]; other site 196164007778 dimer interface [polypeptide binding]; other site 196164007779 ATP binding site [chemical binding]; other site 196164007780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 196164007781 Condensation domain; Region: Condensation; pfam00668 196164007782 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 196164007783 AzlC protein; Region: AzlC; cl00570 196164007784 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 196164007785 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 196164007786 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 196164007787 active site 196164007788 NTP binding site [chemical binding]; other site 196164007789 metal binding triad [ion binding]; metal-binding site 196164007790 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 196164007791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 196164007792 Zn2+ binding site [ion binding]; other site 196164007793 Mg2+ binding site [ion binding]; other site 196164007794 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 196164007795 active site 196164007796 Ap6A binding site [chemical binding]; other site 196164007797 nudix motif; other site 196164007798 metal binding site [ion binding]; metal-binding site 196164007799 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 196164007800 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 196164007801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 196164007802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 196164007803 DNA binding residues [nucleotide binding] 196164007804 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 196164007805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 196164007806 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 196164007807 catalytic residues [active] 196164007808 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 196164007809 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 196164007810 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 196164007811 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 196164007812 active site 196164007813 metal binding site [ion binding]; metal-binding site 196164007814 Fic/DOC family; Region: Fic; cl00960 196164007815 Transposase, Mutator family; Region: Transposase_mut; pfam00872 196164007816 MULE transposase domain; Region: MULE; pfam10551 196164007817 ParB-like partition proteins; Region: parB_part; TIGR00180 196164007818 ParB-like nuclease domain; Region: ParBc; cl02129 196164007819 KorB domain; Region: KorB; pfam08535 196164007820 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 196164007821 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164007822 P-loop; other site 196164007823 Magnesium ion binding site [ion binding]; other site 196164007824 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 196164007825 Magnesium ion binding site [ion binding]; other site 196164007826 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 196164007827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 196164007828 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 196164007829 Domain of unknown function DUF37; Region: DUF37; cl00506 196164007830 Ribonuclease P; Region: Ribonuclease_P; cl00457 196164007831 Ribosomal protein L34; Region: Ribosomal_L34; cl00370